Hydroxy Carboxylic Acid Patents (Class 435/146)
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Publication number: 20130196397Abstract: The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or ?-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB).Type: ApplicationFiled: December 17, 2012Publication date: August 1, 2013Applicant: Genomatica, Inc.Inventors: Mark J. BURK, Stephen J. VAN DIEN, Anthony P. BURGARD, Wei NIU
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Publication number: 20130189747Abstract: The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a sulfur-containing compound. The present invention also relates to methods of using the compositions.Type: ApplicationFiled: August 5, 2011Publication date: July 25, 2013Applicant: NOVOZYMES, INC.Inventor: Feng Xu
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Publication number: 20130189734Abstract: The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 2, 2011Publication date: July 25, 2013Applicant: NOVOZYMES INC.Inventors: Ye Liu, Lan Tang, Junxin Duan
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Publication number: 20130183713Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: August 30, 2011Publication date: July 18, 2013Applicants: NOVOYZMES A/S, NOVOZYMES, INC.Inventor: Marc Morant
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Publication number: 20130177949Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: ApplicationFiled: November 16, 2012Publication date: July 11, 2013Applicant: VERENIUM CORPORATIONInventors: VERENIUM CORPORATION, Darcy Madden
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Publication number: 20130171328Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.Type: ApplicationFiled: June 2, 2011Publication date: July 4, 2013Inventors: Ganesh M. Kishore, Michael Motion, Paula M. Hicks, Jorgen Hansen, Jens Houghton-Larsen, Esben Halkjær Hansen, Michael Dalgaard Mikkelsen, Sabina Tavares, Charlotte Blom
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Patent number: 8470566Abstract: A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol.Type: GrantFiled: February 10, 2012Date of Patent: June 25, 2013Assignee: Genomatica, Inc.Inventors: John D. Trawick, Mark J. Burk, Anthony P. Burgard
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Publication number: 20130157314Abstract: The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a heterocyclic compound. The present invention also relates to methods of using the compositions.Type: ApplicationFiled: August 5, 2011Publication date: June 20, 2013Applicant: NOVOZYMES, INC.Inventors: Feng Xu, Matthew Sweeney, Jason Quinlan
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Publication number: 20130143278Abstract: The present invention provides a process for producing fermentable sugar or a fermentation product from a lignocellulosic feedstock. The process comprises leaching the lignocellulosic feedstock with an aqueous solution to remove at least potassium salts from the lignocellulosic feedstock and without significantly hydrolyzing hemicellulose and cellulose, thereby producing a leached feedstock and leachate. The leachate is removed from the leachate and concentrated. The leached feedstock is hydrolyzed to produce fermentable sugar, which may be fermented to produce a fermentation broth comprising the fermentation product. The concentrated leachate is recirculated to one or more stages in the process involving alkali addition to adjust the pH of a process stream.Type: ApplicationFiled: August 11, 2011Publication date: June 6, 2013Applicant: Iogen Energy CorporationInventors: Jeffrey S. Tolan, Daphne Wahnon, David Geros
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Patent number: 8455236Abstract: Provided herein are improved compositions and methods for the increased production of isoprene. Also provided herein are improved compositions and methods for the increased production of heterologous polypeptides capable of biological activity.Type: GrantFiled: December 23, 2010Date of Patent: June 4, 2013Assignee: Danisco US Inc.Inventors: Zachary Q. Beck, Marguerite A. Cervin, Alex T. Nielsen, Caroline M. Peres
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Publication number: 20130130340Abstract: Microorganisms are genetically engineered to synthesize caffeic acid from simple carbon sources via a tyrosine intermediate by means of a dual pathway that utilizes both endogenous and engineered enzymatic activities.Type: ApplicationFiled: November 6, 2012Publication date: May 23, 2013Applicants: UNVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: UNVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., Yajun YAN, Yuheng LIN
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Publication number: 20130130328Abstract: Plant biomass is immersed in a solution that contains a polar solvent and an imidazolium salt that has a melting point of at least 100° C. As a result, the cellulose and hemicellulose present in the plant biomass are relaxed (decrystallized and depolymerized) and brought into an easy-to-degrade state. Reacting the immersed plant biomass with a cellulase produces saccharide at a high conversion efficiency.Type: ApplicationFiled: June 7, 2011Publication date: May 23, 2013Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Kazuhide Tabata, Nobuhiro Ishida, Risa Nakamura, Satoshi Katahira, Yoshina Takahashi
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Patent number: 8445628Abstract: Disclosed is a copolymer resin composition including a lactic acid copolymer, the lactic acid copolymer containing monomer units represented by the following chemical formulas [1], [2], and [3], wherein a content of a monomer unit represented by the chemical formula [3] is 50 mol % or more and 95 mol % or less, a weight-average molecular weight of the lactic acid copolymer is 20,000 or more and 1,000,000 or less, and a deflection temperature of the lactic acid copolymer under load is 65° C. or higher and 100° C. or lower at a bending stress of 1.80 MPa.Type: GrantFiled: June 30, 2010Date of Patent: May 21, 2013Assignee: Ricoh Company, Ltd.Inventors: Yasuo Yamanaka, Tadakatsu Harada, Hidekazu Yaginuma, Masanobu Munekata, Kenji Tajima, Yasuharu Satoh, Tokuo Matsushima
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Publication number: 20130121978Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.Type: ApplicationFiled: December 17, 2012Publication date: May 16, 2013Applicant: MARRONE BIO INNOVATIONS, INC.Inventor: Marrone Bio Innovations, Inc.
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Patent number: 8435769Abstract: The present invention provides methods for producing shikimic acid. In particular the invention provides methods for producing and isolating shikimic acid from a microorganism. Additionally, the invention provides methods for synthesizing compounds such as oseltamivir and 6-fluoroshikimic acid using shikimic acid produced from microorganisms.Type: GrantFiled: April 11, 2008Date of Patent: May 7, 2013Assignee: Monsanto Technology LLCInventors: Gregg Bogosian, Julia P. Frantz (nee O'Neil)
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Publication number: 20130109067Abstract: The present invention concerns a modified microorganism for the biological preparation of an hydroxy acid of formula (I) wherein the microorganism comprises a two-step metabolic pathway for the production of the said hydroxy acid from a hydroxy keto-acid of formula (II) through an intermediate hydroxy-aldehyde of formula (III), wherein EA1 is an enzyme having a 2-keto-acid decarboxylase activity, and EA2 is an enzyme having hydroxy aldehyde dehydrogenase activity. The invention also concerns a method for the fermentative production of a hydroxy acid.Type: ApplicationFiled: June 28, 2011Publication date: May 2, 2013Applicant: METABOLIC EXPLORERInventors: Philippe Soucaille, Cedric Boisart
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Publication number: 20130095541Abstract: The present invention relates to a method for producing 3-hydroxypropionic acid by culturing in a glycerol-containing medium a mutant microorganism obtained by inserting or amplifying a gene encoding propanediol utilization protein in a microorganism having the abilities to produce coenzyme B12 and produce 3-hydroxypropionic acid using glycerol as a carbon source According to the present invention, 3-hydroxypropionic acid can be produced in high yield from glycerol without having to add expensive coenzyme B12 as a cofactor.Type: ApplicationFiled: May 24, 2011Publication date: April 18, 2013Applicant: Korea Research Institute of Bioscience and BiotechInventors: Chul Ho Kim, Jeong-Woo Seo, Lianhua Luo
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Publication number: 20130095522Abstract: The present invention relates to processes for producing fermentation products from starch-containing material, wherein liquefied mash is saccharified or pre-saccharified using a thermostable carbohydrate-source generating enzyme before fermentation or SSF.Type: ApplicationFiled: April 13, 2011Publication date: April 18, 2013Applicants: NOVOZYMES NORTH AMERICA, INC., NOVOZYMES A/SInventors: Randall Deinhammer, Guillermo Coward-Kelly, Ming Li, Junxin Duan, Zheng Liu, Shiro Fukuyama, Keiichi Ayabe
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Publication number: 20130089903Abstract: The present invention relates to use of inducible promoters in the production of glycolic acid by fermentation. The present invention concerns a method for the production of glycolic acid in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, modulating in said microorganism the expression of a target gene with an external stimulus, and recovering glycolic acid from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in glycolic acid production is under the control of a heterologous inducible promoter whose activity is modulated with said external stimulus. The invention also concerned the modified microorganism used in the method of glycolic acid production.Type: ApplicationFiled: June 15, 2011Publication date: April 11, 2013Applicant: METABOLIC EXPLORERInventors: Wanda Dischert, Rainer Figge, Philippe Soucaille
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Publication number: 20130084608Abstract: The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.Type: ApplicationFiled: August 29, 2012Publication date: April 4, 2013Applicant: Codexis, Inc.Inventors: Lorand Szabo, Zsolt Molnar, Attila Laszlo Nemeth
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Publication number: 20130084600Abstract: This invention is metabolically engineer bacterial strains that provide increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds. In the invention, native NAD-dependent GAPDH is replaced with NADP-dependent GAPDH plus overexpressed NADK. Uses for the bacteria are also provided.Type: ApplicationFiled: November 19, 2012Publication date: April 4, 2013Applicant: WILLIAM MARSH RICE UNIVERSITYInventor: WILLIAM MARSH RICE UNIVERSITY
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Publication number: 20130071898Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: ApplicationFiled: March 23, 2012Publication date: March 21, 2013Applicant: Butamax(TM) Advanced Biofuels LLCInventors: LARRY CAMERON ANTHONY, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica Mcelvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Publication number: 20130065279Abstract: The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.Type: ApplicationFiled: March 30, 2012Publication date: March 14, 2013Applicant: Genomatica, Inc.Inventors: Mark J. BURK, Anthony P. Burgard, Robin E. Osterhout, Jun Sun, Priti Pharkya
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Publication number: 20130067619Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.Type: ApplicationFiled: April 15, 2011Publication date: March 14, 2013Inventors: Jonathan E. Page, Steve Gagne
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Publication number: 20130065286Abstract: Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful products, such as fuels, carboxylic acids and equivalents thereof (e.g., esters and salts). For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol, butanol or organic acids (e.g., acetic or lactic acid), salts of organic acids or mixtures thereof. If desired, organic acids can be converted into alcohols, such as by first converting the acid, salt or mixtures of the acid and its salt to an ester, and then hydrogenating the formed ester. Acetogens or homoacetogens which are capable of utilizing a syngas from a thermochemical conversion of coal or biomass can be utilized to produce the desired product.Type: ApplicationFiled: November 5, 2012Publication date: March 14, 2013Applicant: XYLECO, INC.Inventor: Xyleco, Inc.
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Publication number: 20130065287Abstract: A chemical processing cell includes an upstream membrane and a downstream membrane. The upstream membrane generates a first reaction product. The downstream membrane converts the first reaction product to a second reaction product.Type: ApplicationFiled: April 30, 2012Publication date: March 14, 2013Applicant: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATIONInventors: Dibakar Bhattacharyya, Scott R. Lewis, Saurav Datta
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Publication number: 20130059332Abstract: The present invention relates to a process for the production of an aqueous glucose solution from maize or maize kernels. The invention also relates to a glucose solution obtainable by this process, and to its use for the production of organic compounds. The process according to the invention comprises: a) fractionating dry milling of maize kernels, where the maize kernels are separated into a maize-starch-comprising endosperm fraction and a high-oil germ fraction and, if appropriate, a bran fraction; b) enzymatic liquefaction and saccharification of the maize starch in an aqueous suspension of the endosperm fraction, which gives an aqueous glucose solution comprising maize gluten; and c) depletion of the maize gluten and, if appropriate, any bran present from the aqueous glucose solution.Type: ApplicationFiled: September 14, 2012Publication date: March 7, 2013Applicant: BASF SEInventors: Matthias Boy, Jong-Kyu Choi, Jin Won Chung, Markus Lohscheidt, Jong In Choi, Jae Yeol Seo, Jörg Braun, Mo Se Kim, Sung Hyun Kim, Arno Kochner
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Publication number: 20130059331Abstract: The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.Type: ApplicationFiled: April 19, 2011Publication date: March 7, 2013Applicant: DSM IP ASSETS B.V.Inventors: Paul Klaassen, Bianca Elisabeth Maria Gielesen, Gijsberdina Pieternella Van Suylekom, Wilbert Herman Marie Heijne
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Publication number: 20130052704Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed for use in the production of useful products, such as fuels. For example, systems can use biomass materials, such as cellulosic and/or lignocellulosic materials, to enhance the production of a product, e.g., the production of ethanol and/or butanol by fermentation.Type: ApplicationFiled: October 29, 2012Publication date: February 28, 2013Applicant: XYLECO, INC.Inventor: XYLECO, INC.
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Patent number: 8383375Abstract: The present invention relates to a novel thermostable gluconate dehydratase from the thermoacidophilic archaeon Sulfolobus solfataricus, a coding sequence, and an expression system. The gluconate dehydratase has a molecular weight of about 320,000 to 380,000 daltons as the native protein, and about 40,000 to 50,000 daltons as the monomer protein, and catalyzes the dehydration reaction of aldonic acids to 2-keto-3-deoxy derivatives at temperatures of less than 120° C. The gluconate dehydratase can be produced from native or recombinant host cells and thereby used in the pharmaceutical, agricultural, and other industries.Type: GrantFiled: October 22, 2010Date of Patent: February 26, 2013Assignees: Posco, Postech FoundationInventors: Seonghun Kim, Sun Bok Lee
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Publication number: 20130045519Abstract: Recombinant bacteria having an improved ability to utilize sucrose are provided. These recombinant bacteria have nucleotide sequences encoding sucrose utilization polypeptides integrated into their genome between the yihP gene or its homolog and the yihO gene or its homolog. Additionally, methods of utilizing the recombinant bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: ApplicationFiled: August 16, 2011Publication date: February 21, 2013Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Qi Chen, Qiong Cheng, Jian Ping Lai, Kristin Ruebling-Jass
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Publication number: 20130045513Abstract: A process for the enzymatic reduction of an enoate (1) wherein the C?C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, a. b. in which c. A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R?H or optionally substituted C1-C6-alkyl radical, d. R1, R2 and R3 are independently of one another H, —O—C1-C6-alkyl, —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.Type: ApplicationFiled: October 23, 2012Publication date: February 21, 2013Applicant: BASF SEInventors: Stephan Maurer, Bernhard Hauer, Melanie Bonnekessel, Kurt Faber, Clemens Stückler
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Publication number: 20130045518Abstract: Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: ApplicationFiled: August 16, 2011Publication date: February 21, 2013Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: QI Chen, Qiong Cheng, Jian Ping Lai, Kristin Ruebling-Jass
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Patent number: 8377680Abstract: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.Type: GrantFiled: May 7, 2010Date of Patent: February 19, 2013Assignee: Genomatica, Inc.Inventors: Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya
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Publication number: 20130040297Abstract: The invention relates to a process for the production of cells which are capable of converting arabinose, comprising the following steps: a) Introducing into a host strain that cannot convert arabinose, the genes AraA, araB and araD, this cell is designated as constructed cell; b) Subjecting the constructed cell to adaptive evolution until a cell that converts arabinose is obtained, c) Optionally, subjecting the first arabinose converting cell to adaptive evolution to improve the arabinose conversion; the cell produced in step b) or c) is designated as first arabinose converting cell; d) Analysing the full genome or part of the genome of the first arabinose converting cell and that of the constructed cell; e) Identifying single nucleotide polymorphisms (SNP's) in the first arabinose converting cell; and f) Using the information of the SNP's in rational design of a cell capable of converting arabinose; g) Construction of the cell capable of converting arabinose designed in step f).Type: ApplicationFiled: April 19, 2011Publication date: February 14, 2013Applicant: DSM IP ASSETSInventors: Paul Klaassen, Bianca Elisabeth Maria Gielesen, Wilbert Herman Marie Heijne, Gijsberdina Pieternella Van Suylekom
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Publication number: 20130034885Abstract: Subject of the invention is a process for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into L-carnitine, wherein the process comprises an enzymatic conversion of the ?-lactone into (R)-4-halo-3-hydroxybutyric acid or (R)-4-halo-3-hydroxybutyric acid ester.Type: ApplicationFiled: July 25, 2012Publication date: February 7, 2013Inventors: Ellen Klegraf, Manuela Avi
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Publication number: 20130034884Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.Type: ApplicationFiled: June 21, 2012Publication date: February 7, 2013Applicant: Genomatica, Inc.Inventors: Anthony P. BURGARD, Robin E. Osterhout, Jun Sun, Priti Pharkya
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Publication number: 20130029392Abstract: Hydroxycarboxylic acids are produced by using a microorganism that is improved in ability to produce nicotinamide adenine dinucleotide by deleting, mutating or substituting nadR gene in the microorganism or introducing a gene encoding nicotinic acid phosphoribosyltransferase.Type: ApplicationFiled: September 14, 2012Publication date: January 31, 2013Applicant: MITSUI CHEMICALS, INC.Inventors: Takashi Morishige, Mitsufumi Wada, Hitoshi Takahashi, Daisuke Mochizuki, Junko Tokuda
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Publication number: 20130029391Abstract: After identifying the genes of a novel lipoxygenase and a novel allene oxide synthase derived from Lemna paucicostata SH strain, a plant growth regulating agent (KODA) was produced at high yield by using a Lemna paucicostata strain that expresses the lipoxygenase and the allene oxide synthase.Type: ApplicationFiled: March 11, 2011Publication date: January 31, 2013Inventors: Mineyuki Yokoyama, Toshio Beppu
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Patent number: 8361764Abstract: Novel genes that code for a family of feruloyl esterases that break down ferulic acid crosslinks between polysaccharide chains and between polysaccharides and lignins in plant cell walls are described herein as well as a method of rapid gene discovery.Type: GrantFiled: September 29, 2010Date of Patent: January 29, 2013Assignee: The United States of America, as represented by the Secretary of AgricultureInventors: Dominic W. S. Wong, Victor J. Chan, Meiling Shang, Mary J. Zidwick, Hans H. Liao
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Publication number: 20130017584Abstract: The invention relates to enzymatic methods for hydroxylation in position 2 or 3 of substituted or unsubstituted, linear or branched aliphatic hydrocarbons.Type: ApplicationFiled: March 28, 2011Publication date: January 17, 2013Applicant: NOVOZYMES A/SInventors: Martin Hofrichter, Katrin Scheibner, René Ullrich, Matthias Kinne, Sebastian Peter, Henrik Lund, Lisbeth Kalum
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Publication number: 20130011886Abstract: The present invention comprises pretreating a lignocellulosic feedstock with acid at a pH between about 2.0 and about 3.5 to produce a composition comprising an acid pretreated feedstock. The acid pretreated feedstock is then enzymatically hydrolyzed with cellulases and ?-glucosidase. The glucose is fermented by microorganisms to produce a fermentation broth comprising the fermentation product, followed by recovery of the fermentation product. The steps of enzymatically hydrolyzing and fermenting are conducted at a pH below about 4.0.Type: ApplicationFiled: February 10, 2011Publication date: January 10, 2013Applicant: IOGEN ENERGY CORPORATIONInventors: Jeffrey S. Tolan, Brian Foody
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Patent number: 8349596Abstract: Provided is a composition containing: an isolated and purified polypeptide containing the amino acid sequence of SEQ ID NO: 4; and/or a heterodimeric enzyme containing: the isolated and purified polypeptide containing the amino acid sequence of SEQ ID NO: 4; and an isolated and purified polypeptide containing the amino acid sequence of SEQ ID NO: 2. Also provided is a process for producing a 2-hydroxy-2-methyl carboxylic acid or a salt or ester thereof, wherein the process involves: contacting a 3-hydroxy carboxylic acid or a salt or ester thereof with the above-mentioned composition to produce the 2-hydroxy-2-methyl carboxylic acid or the salt or ester thereof.Type: GrantFiled: November 19, 2010Date of Patent: January 8, 2013Assignee: Evonik Roehm GmbHInventors: Roland H Mueller, Thore Rohwerder
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Patent number: 8344119Abstract: A process for the production of natural ferulic acid, coniferyl alcohol and/or vanillin, includes the bio-conversion of eugenol by a bacteria belonging to the Streptomyces genes including at least one nucleotide sequence SEQ ID NO:1 or SEQ ID NO:8 or any nucleotide sequence having at least 70%, preferably 80% and very preferably 90%, identity with the sequence SEQ ID NO:1 or SEQ ID NO:8.Type: GrantFiled: February 20, 2008Date of Patent: January 1, 2013Assignee: V. Mane FilsInventors: Fanny Lambert, Joseph Zucca, Jean Mane
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Publication number: 20120329110Abstract: A method of increasing 3-HP production efficiency by inhibiting expression of a lactate dehydrogenase, a phosphotransacetylase, and an alcohol dehydrogenase in production of 3-HP using a malonic semialdehyde reduction pathway to prevent metabolite leak and increase a malonyl-CoA pool is disclosed.Type: ApplicationFiled: February 8, 2012Publication date: December 27, 2012Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jae Young KIM, Jae Chan PARK, Sung Min PARK, Hyun Min KOO, Byung Jo YU, Hwa Young CHO, Young kyoung PARK
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Publication number: 20120315682Abstract: The present invention relates to an improved method for the bioconversion of a fermentable carbon source to glycolic acid by a recombinant microorganism bearing new genetic modifications such as ?ldhA, ?mgsA, ?arcA, and ?lldP, ?glcA, ?yjcG and combination of them allowing a production with higher yield, titer and productivity.Type: ApplicationFiled: March 23, 2010Publication date: December 13, 2012Applicant: METABOLIC EXPLORERInventors: Wanda Dischert, Philippe Soucaille
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Publication number: 20120301935Abstract: A method of simultaneously producing 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3-PDO) using a microorganism is provided. The method includes converting glycerol into 3-HP and 1,3-PDO using a recombinant microorganism having both 3-HP and 1,3-PDO producing genes.Type: ApplicationFiled: November 28, 2011Publication date: November 29, 2012Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Byung Jo YU, Sung Min PARK, Jae Young KIM, Young Kyoung PARK, Jae Chan PARK, Hwa Young CHO
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Patent number: 8318464Abstract: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same.Type: GrantFiled: March 25, 2011Date of Patent: November 27, 2012Assignee: Bio Architecture Lab, Inc.Inventors: Yasuo Yoshikuni, Yuki Kashiyama
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Patent number: 8318473Abstract: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same.Type: GrantFiled: March 25, 2011Date of Patent: November 27, 2012Assignee: Bio Architecture Lab, Inc.Inventors: Yasuo Yoshikuni, Yuki Kashiyama
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Publication number: 20120276587Abstract: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus).Type: ApplicationFiled: April 27, 2012Publication date: November 1, 2012Applicant: Danisco US Inc.Inventors: Zachary Q. Beck, Michael C. Miller, Caroline M. Peres, Yuliya A. Primak, Jeff P. Pucci, Derek H. Wells