Saccharomyces Patents (Class 435/255.2)
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Patent number: 8394622Abstract: Novel strains of yeast and methods for improved ethanol production utilizing the yeast strains are disclosed. In particular, the novel yeast strains Saccharomyces cerevisae YE1358 and YE1615 provide for increased fermentation temperature tolerance, as well as tolerance to increased levels of glucose and ethanol, and thereby provide increased ethanol production as compared to ethanol industry standard strains of Saccharomyces cerevisae. The novel yeast strains also generate decreased residual glucose than the ethanol industry standard yeasts.Type: GrantFiled: August 10, 2010Date of Patent: March 12, 2013Assignee: Pioneer Hi Bred International IncInventors: Kimberly J. Forrester, William Rutherford, Doug M. Haefele
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Patent number: 8389459Abstract: A composition including the fermentation supernatant from a fermentation of yeast is intended to be conveniently introduced through the wastewater plumbing system of a private home or other facility into a septic system servicing the home or other facility to substantially accelerate the ability of the bacteria resident in the septic system to substantially digest biologically available organic compounds present in the septic system, and methods of accomplishing the same.Type: GrantFiled: March 2, 2011Date of Patent: March 5, 2013Assignee: Advanced Biocatalytics CorporationInventors: John W. Baldridge, Carl W. Podella
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Patent number: 8383365Abstract: Modified FGF-21 polypeptides and uses thereof are provided.Type: GrantFiled: March 18, 2011Date of Patent: February 26, 2013Assignee: AMBRX, Inc.Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore (Nee Ho), Jason Pinkstaff, Vadim Kraynov
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Publication number: 20130045301Abstract: The present invention provides a new wine yeast product in a frozen form. The product is produced in a fermenter, concentrated, cryoprotectants are added. This mixture is then frozen at ?50° C. What makes this product unique is that besides the fact that it is frozen, it can be directly added to grape juice as no rehydration is required because the yeast was not dehydrated in the production process.Type: ApplicationFiled: April 26, 2011Publication date: February 21, 2013Applicant: CHR. HANSEN A/SInventors: Jan Hendrik Swiegers, Annicka Bunte, Sylvester Holt, Mansour Badaki
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Patent number: 8361762Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.Type: GrantFiled: September 15, 2009Date of Patent: January 29, 2013Assignees: Danisco US Inc., The Goodyear Tire & Rubber CompanyInventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Dmitrii V. Vaviline, Alex T. Nielsen
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Publication number: 20130023021Abstract: The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.Type: ApplicationFiled: July 10, 2012Publication date: January 24, 2013Applicant: SCANDINAVIAN TECHNOLOGY GROUP ABInventors: Anneli Nilsson, Gunnar Lidén, Marie-Francoise Gorwa-Grauslund, Bärbel Hahn-Hägerdal, Carl Tobias Modig, Joao Ricardo Moreira De Almeida
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Publication number: 20130011895Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.Type: ApplicationFiled: July 20, 2012Publication date: January 10, 2013Applicant: XYLECO, INC.Inventors: Marshall Medoff, Thomas Craig Masterman
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Publication number: 20120329138Abstract: A process for separation of a mixture containing a microbial substance and a liquid using deformable filter is provided.Type: ApplicationFiled: December 19, 2011Publication date: December 27, 2012Applicant: SHELL OIL COMPANYInventors: Henry Van Kaathoven, Johannes Pieter Haan, Wilhelmus Maria Bond, Johannes Leendert Willem Cornelis Den Boestert
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Publication number: 20120309069Abstract: The invention relates to an isolated Saccharomyces cerevisiae strain having NMI accession no. V09/024011, and to a method of producing ethanol and distiller's grains using the strain.Type: ApplicationFiled: September 27, 2010Publication date: December 6, 2012Inventors: Philip John Livingstone Bell, Paul Victor Attfield
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Patent number: 8323717Abstract: The method of producing baker's yeast involves producing yeast from a substrate composed of date syrup (Dips) diluted by molasses in sufficient quantity to lower the concentration of organic acids present in the date syrup that are toxic to yeast to safe levels, preferably a 1:1 mixture (w/w) of date syrup (Dips) and molasses. The substrate is inoculated with viable cells of Saccharomyces cerevisiae yeast and placed in a bioreactor or fermentation vessel. The yeast is produced by a fed-batch process to ensure continuous yeast production and prevent or minimize the production of alcohol by the yeast, additional increments of the substrate being added about hourly for the duration (about 12 hours) of the yeast propagation process. The process produces baker's yeast comparable in quality to yeast produced from a pure molasses substrate for such purposes as making bread, and in sufficient quantity to be practical for industrial production.Type: GrantFiled: November 24, 2010Date of Patent: December 4, 2012Assignees: King Faisal University, King Abdulaziz City for Science and TechnologyInventors: Salah Mohammed Aleid, Siddig Hussein Hamad, Fahad Mohammed Al-Jasass
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Patent number: 8318475Abstract: The present invention relates to compositions comprising yeast cells and/or yeast cell components and methods for producing and utilizing the same. In particular, the invention provides novel yeast comprising altered cell wall structure (e.g., clay and/or clay component(s) integrated (e.g., interlaced) into cell wall(s) and/or cell wall(s) comprising altered glucan:mannan ratio), methods of producing the same, compositions comprising and/or derived from the same, and methods of using the same (e.g., to sequester and/or adsorb bacteria and toxins). Compositions and methods of the invention find use in a variety of applications including dietary (e.g., admixing with feedstuffs or otherwise feeding to animals), therapeutic, prophylactic (e.g. admixing with bedding sources and/or other materials that come into contact with animals, usage during food and beverage processing and manufacture, and usage during filtration of liquids) as well as research applications.Type: GrantFiled: August 13, 2010Date of Patent: November 27, 2012Assignee: Alltech, Inc.Inventors: Alexandros Yiannikouris, Ursula Anne Thielen
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Publication number: 20120295335Abstract: A method to prevent contamination of feed line(s) and nutrient feed reservoirs(s) is disclosed. In this method the growth medium which flows from the nutrient feed reservoir through the feed line to the bioreactor contains at least one nutritional component supplied at a concentration which is inhibitory to cell growth. The inhibitory nutritional component in the growth medium prevents back growth of cells from the bioreactor into the feed line(s). The growth medium with inhibitory nutritional component is diluted in the bioreactor.Type: ApplicationFiled: November 16, 2011Publication date: November 22, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventor: Scott Christopher Jackson
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Publication number: 20120264649Abstract: The invention provides molecules useful for enhancing charge transport across membranes, such as electron transport across membranes, and methods of using such molecules, for example in improving the performance of a microbial fuel cell or in staining microbes for observation. The amphiphilic molecule comprises a conjugated core with hydrophilic groups on either end. The amphiphilic molecule inserts into the membrane of a microbe and facilitates charge transfer across the membrane of the microbe.Type: ApplicationFiled: June 10, 2011Publication date: October 18, 2012Inventors: Guillermo C. BAZAN, Logan E. GARNER, James J. SUMNER
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Publication number: 20120258104Abstract: The present invention relates to a delivery system that comprises a conjugate that facilitates the delivery of a compound such as a biologically-active macromolecule, a nucleic acid or a peptide in particular, into a cell. The present invention also relates to said conjugate for delivery of a compound, such as a biologically-active macromolecule, a nucleic acid or a peptide, into a cell. The present invention further relates to a pharmaceutical composition comprising said conjugate and to its use. The present invention also relates to a method of delivering a compound to a cell or an organism, preferably a patient.Type: ApplicationFiled: July 22, 2010Publication date: October 11, 2012Applicant: Cenix Bioscience GMBHInventors: Christophe J. Echeverri, Birte Sonnichsen, Reinhard Wähler, Mike Werner Helms
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Publication number: 20120252061Abstract: The present invention relates to novel yeast strains intended for alcohol production. The present invention also relates to yeasts obtained by cultures of said yeast strains and use thereof for producing alcohol, in particular in a toxic fermentation medium. Another object of the invention relates to a method of selecting yeast strains that are resistant to a toxic fermentation medium.Type: ApplicationFiled: December 14, 2010Publication date: October 4, 2012Applicant: LESAFFRE ET COMPAGNIEInventors: Jean-Michel Bavouzet, Jean-Marc Ladriere, Annie Tbaikhi, William Wyme
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Publication number: 20120252102Abstract: Systems, compositions, and methods for the anaerobic oxidative bioremediation of a contaminant contained within a treatment zone associated with a contaminated region. These systems, compositions, and methods may include a bioremediation formulation that includes a high-mobility oxidant, a low-mobility oxidant, and a nutrient source. The high-mobility oxidant may include a nitrate salt. The low-mobility oxidant may include a sulfate salt. The nutrient source may include brewer's yeast and/or a complex sugar. The bioremediation formulation also may include one or more additional components, including a phosphate salt, a surfactant, a solvent, a chemical oxidant, and/or a bio-augmentation species.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Applicant: Bioremediation Specialists, LLCInventor: Troy John Fowler
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Patent number: 8263374Abstract: The present invention relates to a composite yeast suitable for high concentration alcohol fermentation from sugar-containing raw materials, characterizing in that the composite yeast comprises any kind of dried yeast selected from Brewers yeast Saccharomyces cerevisiae Hansen of Saccharomyces cerevisiae, grape wine yeast Saccharomyces uvarum Beijerinek, and nutritious materials which are necessary for yeast growth, the nutritious materials include: the dried yeast 40-70 parts by weight, a nitrogen source 20-40 parts by weight, a phosphorous source 5-10 parts by weight, an other inorganic salt 2.5-5 parts by weight, a trace vitamin 1-2.5 parts by weight and a bacteriostatic 0.5-1.2 parts by weight. The present invention further relates to a method for preparation of the composite yeast suitable for high concentration alcohol fermentation from sugar-containing raw materials.Type: GrantFiled: July 30, 2008Date of Patent: September 11, 2012Assignee: Angel Yeast Co., Ltd.Inventors: Xuefeng Yu, Zhihong Li, Minghua Yu, Juan Yao, Zhijun Li, Daiwu Liu
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Patent number: 8257960Abstract: The present invention relates to novel microorganisms having the efficiency of removing an offensive odor from organic waste and the use thereof. More particularly, the novel microorganisms have the effects of preventing or removing the offensive odor from organic waste, killing insects and fungi, preventing decomposition, and promoting digestion and fermentation. The inventive microorganisms have the effects of preventing or removing the offensive odor from organic waste and killing noxious insects and plant pathogenic fungi, can be used as feed additives and antibiotic substitutes, and also are useful for the preparation of fermented healthy foods.Type: GrantFiled: October 19, 2006Date of Patent: September 4, 2012Inventor: Se-Joon Park
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Patent number: 8257959Abstract: The present invention relates to methods for producing Saccharomyces strains that are capable of growth on xylose as a sole carbon source at a desired growth rate, (such as at least one generation per 48 hours), strains made by such methods, and Saccharomyces strains that grow at a growth rate of at least one generation per 48 hours using xylose as a sole carbon source for growth made by non-recombinant methods.Type: GrantFiled: June 8, 2005Date of Patent: September 4, 2012Assignee: Microbiogen Pty LtdInventors: Philip John Livingstone Bell, Paul Victor Attfield
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Publication number: 20120190095Abstract: Provided is a composition which comprises yeast cells treated with, or grown from yeast cells treated with electromagnetic waves in the range of 30 GHz to 300 GHz. Said composition may be used for the treatment of neurodegenerative diseases or disorders. A method relating to the composition is also provided.Type: ApplicationFiled: August 26, 2010Publication date: July 26, 2012Applicant: MB Milmed ABInventors: Kent Törnqvist, Maria Sibileva, Peter Ek, Anders Fredriksson, Trevor Archer, Tatiana Blomqvist, Dmitry Mudrik, Natalia Golant, Ludmila Balakireva
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Publication number: 20120190107Abstract: Methods of enhanced protein transduction are provided. Aspects of the methods include contacting a cell with a transduction protein, where the transduction protein includes both a protein-of-interest domain and a protein transduction domain, and a nucleic acid transfection agent. Also provided are systems and kits that find use in practicing methods according to embodiments of the invention. The methods, systems and kits find use in a variety of different applications.Type: ApplicationFiled: January 25, 2012Publication date: July 26, 2012Inventors: Dwayne Bisgrove, Hiroaki Sagawa
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Publication number: 20120192296Abstract: The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof.Type: ApplicationFiled: March 30, 2010Publication date: July 26, 2012Applicants: Universite de Lausanne, Edimer Biotech S.A.Inventors: Pascal Schneider, Nathalie Dunkel, Stephane Demotz
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Patent number: 8227235Abstract: Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.Type: GrantFiled: September 21, 2009Date of Patent: July 24, 2012Assignee: Alpharma, LLCInventors: James Skinner, Doug Rupp
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Publication number: 20120184030Abstract: The present invention relates to methods for establishing a symbiosis, including the following steps: selecting an organism or an organelle to constitute the symbiont and an organism to constitute the host, the latter not existing naturally in a symbiotic relationship; contacting the symbiont and the host; and maintaining the combination of the symbiont and the host.Type: ApplicationFiled: July 19, 2010Publication date: July 19, 2012Inventors: Zoran Dermanovic, Miroslav Radman
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Patent number: 8211687Abstract: A thixotropic gel suitable for use in subsurface bioremediation is provided along with a process of using the gel. The thixotropic gel provides a non-migrating injectable substrate that can provide below ground barrier properties. In addition, the gel components provide for a favorable environment in which certain contaminants are preferentially sequestered in the gel and subsequently remediated by either indigenous or introduced microorganisms.Type: GrantFiled: June 17, 2010Date of Patent: July 3, 2012Assignee: Savannah River Nuclear Solutions, LLCInventor: Brian D. Riha
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Patent number: 8206957Abstract: A process for preparing optically active saturated aldehydes or alcohols of the formula (2) from ?,?-unsaturated aldehydes of the formula (1) by reduction in the presence of an enoate reductase (i) having the polypeptide sequence SEQ ID No. 1 or 2, or (ii) having a polypeptide sequence which is at least 80% identical to the sequence of SEQ ID No. 1 or 2.Type: GrantFiled: December 19, 2006Date of Patent: June 26, 2012Assignee: BASF SEInventors: Andreas Schädler, Thomas Friedrich, Rainer Stürmer, Sabine Rinck
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Patent number: 8202699Abstract: Use of a biological photoreceptor as light-controlled ion channel for the alteration of the ion conductivity of a membrane by means of light. The photoreceptor used comprises an apoprotein and a light-sensitive polyene covalently bound to the apoprotein, said polyene interacting with the apoprotein and functioning as a light-sensitive gate.Type: GrantFiled: May 18, 2010Date of Patent: June 19, 2012Assignee: Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V.Inventors: Peter Hegemann, Georg Nagel, Ernst Bamberg
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Publication number: 20120136046Abstract: The present invention relates to the use of fujimycin for the treatment of a disorder related to the chronological and/or replicative life-span of a cell, and to methods for increasing the replicative life span of a cell, said method comprising disrupting the function of a polynucleotide or gene encoding a polypeptide comprising SEQ ID No: 1, 3 or 5.Type: ApplicationFiled: July 8, 2010Publication date: May 31, 2012Applicant: Chronos Therapeutics LimitedInventors: Elizabeth Jane Mellor, Michael Youdell, Jonathan Ayling, Alexandre Akoulitchev
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Patent number: 8188028Abstract: Surfactant-containing compositions are described which include a protein component that has the effect of improving the surface-active properties of the surfactants contained in the compositions. The surfactant-containing compositions having the protein component demonstrate significantly lower critical micelle concentrations (CMC), reduced surface tensions, and reduced interfacial tensions than do comparable compositions having no protein component. In addition, the surfactant-containing compositions having the protein component has the effect of converting greasy waste contaminants to surface active materials.Type: GrantFiled: January 11, 2010Date of Patent: May 29, 2012Assignee: Advanced BioCatalytics CorporationInventors: John W. Baldridge, Carl W. Podella
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Publication number: 20120128853Abstract: The method of producing baker's yeast involves producing yeast from a substrate composed of date syrup (Dips) diluted by molasses in sufficient quantity to lower the concentration of organic acids present in the date syrup that are toxic to yeast to safe levels, preferably a 1:1 mixture (w/w) of date syrup (Dips) and molasses. The substrate is inoculated with viable cells of Saccharomyces cerevisiae yeast and placed in a bioreactor or fermentation vessel. The yeast is produced by a fed-batch process to ensure continuous yeast production and prevent or minimize the production of alcohol by the yeast, additional increments of the substrate being added about hourly for the duration (about 12 hours) of the yeast propagation process. The process produces baker's yeast comparable in quality to yeast produced from a pure molasses substrate for such purposes as making bread, and in sufficient quantity to be practical for industrial production.Type: ApplicationFiled: November 24, 2010Publication date: May 24, 2012Inventors: SALAH MOHAMMED ALEID, Siddig Hussein Hamad, Fahad Mohammed Al-Jasass
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Publication number: 20120124898Abstract: This invention provides co-cultures of photosynthetic microorganisms and biofuel producing microorganisms. In certain embodiments, polysaccharide-producing, photosynthetic microorganisms are microalgae having frustules provide a substrate on which biofuel-producing microorganisms can grow. In other embodiments, the photosynthetic microorganisms produce a lipid and the non-photosynthetic microorganisms produce a solvent in which the lipid is soluble.Type: ApplicationFiled: July 21, 2011Publication date: May 24, 2012Inventor: Pamela R. Contag
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Patent number: 8158396Abstract: The present invention provides a novel process for ethanol fermentation which uses a high concentration of fresh yeast to co produce ethanol and good quality yeast.Type: GrantFiled: October 3, 2006Date of Patent: April 17, 2012Assignee: Alternative Fuels Corporation Pty LtdInventors: David Graham Maclennan, Mary Elizabeth Maclennan
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Publication number: 20120090054Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: December 19, 2011Publication date: April 12, 2012Applicants: Novozymes, Inc., Novozymes A/SInventors: Paul Harris, Elena Valsenko, Elizabeth Zaretsky, Marcus Sakari Kauppinnen
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Publication number: 20120077181Abstract: The cryopreservation of cells and tissue cultures for long term storage of cells, cell constructs or three-dimensional complex tissues assemblies is based on the use of a collagen cell carrier (CCC) having a specific composition and thickness and appropriate mechanical properties which are maintained after thawing. The collagen cell carrier provides a suitable support for the cryopreservation resulting in high survival rates after thawing and providing cells and tissue assemblies already adhered to a mechanically stable and biocompatible support. Frozen collagen carrier-cells assemblies, the frozen artificial cell constructs or three-dimensional complex tissue assemblies obtainable by the method and the use thereof after thawing are also disclosed.Type: ApplicationFiled: February 18, 2010Publication date: March 29, 2012Inventors: Timo Schmidt, Lothar Just, Franz Maser, Holger Becker
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Patent number: 8129143Abstract: The present invention relates to a eukaryotic cell containing peroxisomes that are capable to fuse with a membrane-structure of the cell involved in the secretory pathway of the cell. In this way, the eukaryotic cell is able to release the peroxisomal content outside the cell. The invention also relates to a method for production of a compound of interest in said eukaryotic cell wherein said compound of interest is present in the peroxisome of the cell. Said compound of interest will accumulate in the peroxisome by a signal promoting peroxisome localization. Preferred host cells are filamentous fungal cells.Type: GrantFiled: October 13, 2005Date of Patent: March 6, 2012Assignee: DSM IP Assets B.V.Inventors: Cornelis Maria Jacobus Sagt, Petrus Johannes Fredrik ten Haaft, Johannes Hendrik de Winde, Panagiotis Sarantinopoulos
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Publication number: 20120034648Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.Type: ApplicationFiled: March 5, 2009Publication date: February 9, 2012Inventors: Paul Klaassen, Jan Metske Van Der Laan, Bianca Elisabeth Maria Gielesen, Gijsberdina Pieternella Van Suylekom
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Publication number: 20120028327Abstract: Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection media that can be used to isolate such variants include pentose sugars such as D-xylose, L-glutamine and 2-deoxy-glucose. Mutations in the Grr1 and Red genes in some strains also produce variants that can grow on sugars including the pentose D-xylose in the presence of 2-deoxy-glucose.Type: ApplicationFiled: February 25, 2010Publication date: February 2, 2012Inventors: Mark Goebl, Cary Woods, Ross Cocklin, Josh Heyen
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Publication number: 20120003740Abstract: This document discloses electroporation vessels, electrocompetent cells that have been aliquoted and frozen in electroporation vessels, and a number of other apparatuses, kits, and methods for electroporation. Some embodiments of electroporation vessels described herein may include a pair of opposing walls that are downwardly angled toward one another in a gap between two electrode surfaces. Further embodiments of devices and methods described herein may eliminate the need for an end user to transfer competent cells from a capped tube to electroporation cuvette, thereby saving time and producing less waste.Type: ApplicationFiled: December 28, 2010Publication date: January 5, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Laura Vozza-Brown, Harry Yim, John Cameron, Matthew O'Banion, Adam Scott Henry, Lisa Marie Olivier
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Patent number: 8088620Abstract: The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.Type: GrantFiled: November 5, 2004Date of Patent: January 3, 2012Assignee: Metabolic ExplorerInventors: Gwénaëlle Bestel-Corre, Cédric Boisart, Michel Chateau, Benjamin Gonzalez, Philippe Soucaille, Rainer Figge, Olivier Zink
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Publication number: 20110306083Abstract: Methods are provided for selecting microbial strains with improved properties for fermentation and/or bioproduct production. A salt selection is employed to identify mutants with improved bioproduct tolerance, titer, or osmotic tolerance relative to a microbial strain from which they were derived.Type: ApplicationFiled: June 13, 2011Publication date: December 15, 2011Applicant: Cobalt Technologies, Inc.Inventor: Jeanette M. MUCHA
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Publication number: 20110301030Abstract: The invention relates to a strain of Saccharomyces cerevisae characterized in that it is selected from strain No. I-3936 deposited on Mar. 4 2008 at the CNCM, strain No. I-3937 deposited on Mar. 4 2008 at the CNCM, strain No. I-3938 deposited on Mar. 4 2008 at the CNCM, and strain No. I-3939 deposited on Mar. 4 2008 at the CNCM. The invention also relates to a phytosanitary composition and to a method for treating or protecting plants against diseases caused by pathogens, using said strain.Type: ApplicationFiled: January 26, 2010Publication date: December 8, 2011Applicant: LESAFFRE ET COMPAGNIEInventors: Philippe Pujos, Didier Colavizza, Pascal Vandekerckove
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Publication number: 20110287143Abstract: The present invention relates in general to the field of health and well-being. In particular, the present invention relates to temperature sensitive micro-organisms and their use as vehicle for the preparation of a composition to deliver compounds, for example nutrients, to specific regions of a body.Type: ApplicationFiled: July 1, 2009Publication date: November 24, 2011Applicant: NESTEC S.A.Inventors: Christof Gysler, Peter Niederberger, Nicolas Page, Christelle Schaffer-Lequart
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Publication number: 20110223287Abstract: Provided is a method for producing a yeast containing glutamic acid at a high concentration. In the method for culturing a yeast, a yeast in a stationary growth phase is subjected to liquid culture under the conditions that the pH of a liquid medium is 7.5 or higher and lower than 11. After the pH of the liquid medium for the yeast in a stationary growth phase is adjusted to 7.5 or higher and lower than 11, the yeast is further cultured, whereby a yeast with a high glutamic acid content can be produced. In the invention, as the yeast, Saccharomyces cerevisiae or Candida utilis can be used. Therefore, by using the yeast with a high glutamic acid content obtained by the above-said method and the extract obtained by extraction from the yeast, a seasoning composition and a food or drink with a high glutamic acid content can be provided.Type: ApplicationFiled: October 30, 2009Publication date: September 15, 2011Applicant: Asahi Breweries, Ltd.Inventors: Ichiro Shibuya, Hiroaki Okano, Yoshitomo Kanaoka, Nobuchika Takesue
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Patent number: 8012931Abstract: Modified FGF-21 polypeptides and uses thereof are provided.Type: GrantFiled: March 19, 2008Date of Patent: September 6, 2011Assignee: Ambrx, Inc.Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Ho, Jason Pinkstaff, Vadim Kraynov
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Publication number: 20110201093Abstract: The present invention is directed to the enhanced production of ethanol from fermentation using an ethanol producing microorganism. In particular, the present invention provides a process for the enhanced growth and metabolism of an ethanol producing microorganism (e.g., yeast), for the purpose of increasing or enhancing ethanol production, both in terms of total ethanol produced and in terms of the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products (i.e., ethanol). In accordance with this invention bicarbonate ions are used to enhance ethanol fermentation and/or reduce the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products, i.e., ethanol. The present invention can also be used for enhancing fermentation end products in, for example, the fuel ethanol, industrial, cheese, brewing, and wine making industries.Type: ApplicationFiled: April 28, 2011Publication date: August 18, 2011Applicant: CHURCH & DWIGHT CO., INC.Inventors: Melvin H. Czechowski, Steven A. Bolkan
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Publication number: 20110183394Abstract: The invention relates to use of a substrate comprising C5 compound-containing material, in the growth of Saccharomyces yeast or the production of a product of Saccharomyces yeast, wherein the C5 compound-containing material is: (a) C5 compound-containing material obtained from lignocellulosic hydrolysate; (b) C5 compound-containing material obtained from fermentation of lignocellulosic hydrolysate; or (c) a mixture of (a) and (b). The invention also relates to a method of producing Saccharomyces yeast biomass or a product of Saccharomyces yeast using the substrate, and to methods of producing ethanol comprising incubating Saccharomyces yeast produced by the use or method. The invention further relates to strains of Saccharomyces yeast suitable for the use or methods.Type: ApplicationFiled: April 28, 2009Publication date: July 28, 2011Applicant: MICROBIOGEN PTY LTDC C/O Peter Hunt & AssociatesInventors: Philip John Livingstone Bell, Paul Victor Attfield, Arthur Kollaras
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Publication number: 20110177557Abstract: The invention relates to a fusion protein and a method for the generation of the fusion protein of the invention. Further, the invention relates to the use of the fusion protein of the invention for the generation of induced pluripotent cells. Moreover, the invention relates to a composition comprising at least one fusion protein of the invention.Type: ApplicationFiled: June 15, 2009Publication date: July 21, 2011Applicant: Life & Brain GmbHInventors: Frank Edenhofer, Manal Bosnali, Michael Peitz, Marc-Christian Thier
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Publication number: 20110165660Abstract: Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.Type: ApplicationFiled: March 11, 2011Publication date: July 7, 2011Applicant: VERDEZYNE, INC.Inventors: Stephen Picataggio, Kirsty Anne Lily Salmon, Jose Miguel LaPlaza
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Publication number: 20110165612Abstract: The present invention relates to novel stable yeast strains, to a novel method for obtaining such strains, and to a novel method for evaluating the stability of a yeast strain. The present invention also relates to the yeasts obtained from these novel stable yeast strains, and to the use thereof for producing alcohol.Type: ApplicationFiled: September 10, 2009Publication date: July 7, 2011Inventors: Didier Colavizza, Renaud Toussaint
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Publication number: 20110159554Abstract: The invention provides: yeast having cellulose degradation ability that degrades cellulose outside the cell and glucose accumulation ability that accumulates, in a reaction liquid, glucose produced from cellulose as a result of the cellulose degradation ability, when the yeast was brought into contact with cellulose in the reaction liquid; and a method for producing glucose, wherein the glucose is produced from cellulose, the method comprising the step of bringing the yeast into contact with cellulose in a reaction liquid and the step of separating and collecting, from the reaction liquid, glucose accumulated in the reaction liquid as a result of the contact of the yeast with the cellulose.Type: ApplicationFiled: March 10, 2009Publication date: June 30, 2011Inventors: Katsuyuki Takahashi, Mitsufumi Wada, Sakurako Kimura, Ryota Fujii