Saccharomyces Patents (Class 435/255.2)
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Patent number: 7566563Abstract: Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also are provided.Type: GrantFiled: August 21, 2008Date of Patent: July 28, 2009Assignee: Archer-Daniels-Midland CompanyInventors: Beth Fatland-Bloom, Gyan Rai, P. John Rayapati, Nyerhovwo John Tonukari
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Publication number: 20090186400Abstract: A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which an ascorbic acid compound or a salt thereof is added to a yeast concentrate separated from a fungus culture liquid of the yeast, and the concentrate is then dried, a dry yeast containing SAMe obtained by the production method, and a composition for oral ingestion formed by molding the dry yeast. A method capable of producing a dry yeast containing SAMe in a high concentration excellent in storage stability conveniently at low cost is established, and a dry yeast containing SAMe obtained by the production method and a composition for oral ingestion formed by molding the dry yeast are provided.Type: ApplicationFiled: May 15, 2007Publication date: July 23, 2009Inventors: Kentarou Takano, Shinyo Gayama
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Publication number: 20090170174Abstract: The present invention is directed to the enhanced production of ethanol from fermentation using an ethanol producing microorganism. In particular, the present invention provides a process for the enhanced growth and metabolism of an ethanol producing microorganism (e.g., yeast), for the purpose of increasing or enhancing ethanol production, both in terms of total ethanol produced and in terms of the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products (i.e., ethanol). In accordance with this invention bicarbonate ions are used to enhance ethanol fermentation and/or reduce the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products, i.e., ethanol. The present invention can also be used for enhancing fermentation end products in, for example, the fuel ethanol, industrial, cheese, brewing, and wine making industries.Type: ApplicationFiled: December 31, 2007Publication date: July 2, 2009Inventors: Melvin H. Czechowski, Steven A. Bolkan
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Patent number: 7507554Abstract: The present invention describes a process for the production of ethanol by harvesting starch-accumulating filament-forming or colony-forming algae to form a biomass, initiating cellular decay of the biomass, fermenting the biomass in the presence of a yeast, and the isolating the ethanol produced. The present invention further relates to processing of the biomass remaining after ethanol production to recovering biodiesel starting materials and/or generation of heat and carbon dioxide via combustion.Type: GrantFiled: May 17, 2006Date of Patent: March 24, 2009Assignee: Propulsion Logic, LLCInventors: Ronnie A. Bush, Kevin M. Hall
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Publication number: 20090070900Abstract: Novel materials containing dispersed or aligned biomolecules and/or cells and biomasses, which are preferably chemically modified, can be preferably used as conductors, semiconductors, transistors, resistors or non-conductors and as artificial jewels and gemologic materials, materials for use in computer, aerospace, marine and automobile industries, as well as modified alloys for machines and pipelines, boring and drilling machines and materials, and for pumps and for oil industry, as well as for furniture, for wood paper and cellulose industry, as well as for textile industry.Type: ApplicationFiled: June 9, 2008Publication date: March 12, 2009Inventor: Alexander Cherkasky
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Publication number: 20090061502Abstract: The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.Type: ApplicationFiled: August 29, 2008Publication date: March 5, 2009Applicant: FORSKARPATENT I SYD ABInventors: Anneli Nilsson, Gunnar Liden, Marie-Francoise Gorwa-Grauslund, Barbel Hahn-Hagerdal, Carl Tobias Modig, Joao Ricardo Moreira De Almeida
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Publication number: 20090053792Abstract: The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The microorganisms may be used to produce a variety of products of interests, such as recombinant proteins, nucleic acids, such as DNA, amino acids, and chemicals.Type: ApplicationFiled: September 8, 2006Publication date: February 26, 2009Applicant: SCARAB GENOMICS, LLCInventors: Frederick R. Blattner, John Walter Campbell, Nian Shi, Buffy Stahl
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Publication number: 20090047719Abstract: The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby theone or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO.Type: ApplicationFiled: August 10, 2007Publication date: February 19, 2009Inventors: Anthony P. Burgard, Stephen J. Van Dien, Mark Burk
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Publication number: 20090041899Abstract: A method of producing hexose oxidase by recombinant DNA technology, recombinant hexose oxidase and the use of such enzyme, in particular in the manufacturing of food products such as doughs and dairy products, animal feed, pharmaceuticals, cosmetics, dental care products and in the manufacturing of lactones. Suitable sources of DNA coding for the enzyme are marine algal species including Chondrus crispus, Iridophycus flaccidum and Euthora cristata. In useful embodiments, the recombinant hexose oxidase is produced by Pichia pastoris, Saccharomyces cerevisiae or E. coli.Type: ApplicationFiled: October 31, 2007Publication date: February 12, 2009Applicant: Danisco A/SInventors: Peter Stougaard, Ole Cai Hansen
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Publication number: 20090031454Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid hydroxylases. The invention also provides recombinant expression vectors including hydroxylase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for the production of hydroxyl fatty acids such as 12-hydroxyoctadec-9-enoic acid (ricinoleic acid).Type: ApplicationFiled: June 22, 2007Publication date: January 29, 2009Applicants: Bioriginal Food & Science Corp., University of SaskatchewanInventors: Dauenpen Meesapyodsuk, Xiao Qiu
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Publication number: 20090017451Abstract: The present invention relates to methods for generating and detecting recombinant DNA sequences in Saccharomyces cerevisiae and plasmids and Saccharomyces cerevisiae cells used for conducting the inventive methods.Type: ApplicationFiled: January 28, 2005Publication date: January 15, 2009Inventors: Kathleen Smith, Rhona Borts
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Publication number: 20090004726Abstract: Furfural and 5-hydroxymethylfurfural (HMF) are representative inhibitors to ethanologenic yeast generated from biomass pretreatment using dilute acid hydrolysis. Few yeast strains tolerant to inhibitors are available. A novel tolerant strain of Saccharomyces cerevisiae, NRRL Y-50049, having enhanced biotransformation ability to convert furfural to furan methanol (FM), HMF to furan di-methanol (FDM), and is able to produce a normal yield of ethanol as an initial culture.Type: ApplicationFiled: June 23, 2008Publication date: January 1, 2009Applicant: The United States of America, as represented by the Secretary of AgricultureInventor: Zonglin L. Liu
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Patent number: 7470532Abstract: The present invention relates to a fungal C16/18 fatty acid elongase that is able to catalyze the conversion of palmitate (16:0) to stearic acid (18:0). Specifically, the nucleotide sequence of a Mortierella alpina C16/18 fatty acid elongase is provided (designated as “ELO3”). Methods of increasing microbial oil production, increasing carbon flux into the polyunsaturated fatty acid biosynthetic pathway and increasing the content of polyunsaturated fatty acids by over-expression of the C16/18 fatty acid elongase are described herein. Most desirably, the substrate specificity of the instant ELO3 will be particularly useful to enable accumulation of long-chain polyunsaturated fatty acids in oleaginous yeast, such as Yarrowia lipolytica.Type: GrantFiled: October 19, 2005Date of Patent: December 30, 2008Assignee: E.I. du Pont de Nemours and CompanyInventors: Daniel Joseph Macool, Zhixiong Xue, Quinn Qun Zhu
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Patent number: 7452670Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.Type: GrantFiled: December 3, 2004Date of Patent: November 18, 2008Assignees: University of Washington, Whitehead Institute for Biomedical ResearchInventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
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Patent number: 7452688Abstract: The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the antifungal activity of a test substance using the transformed cell, and a method of searching an antifungal compound using the method, and the like.Type: GrantFiled: October 31, 2003Date of Patent: November 18, 2008Assignee: Sumitomo Chemical Company, LimitedInventor: Hiroki Nakajima
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Publication number: 20080261861Abstract: The present invention provides a 2 ?m-family plasmid comprising a polynucleotide sequence insertion, deletion and/or substitution between the first base after the last functional codon of at least one of either a REP2 gene or an FLP gene and the last base before the FRT site in an inverted repeat adjacent to said gene.Type: ApplicationFiled: December 23, 2004Publication date: October 23, 2008Applicant: DELTA BIOTECHNOLOGY LIMITEDInventors: Darrell Sleep, Christopher John Arthur Finnis
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Publication number: 20080255045Abstract: Modified FGF-21 polypeptides and uses thereof are provided.Type: ApplicationFiled: March 19, 2008Publication date: October 16, 2008Applicant: AMBRX, INC.Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian HO, Jason PINKSTAFF, Vadim KRAYNOV
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Publication number: 20080226660Abstract: Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections.Type: ApplicationFiled: March 18, 2005Publication date: September 18, 2008Inventors: Janine T. Bryan, Michelle K. Brownlow, Loren D. Schultz, Kathrin U. Jansen
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Publication number: 20080199926Abstract: The invention provides a non-naturally occurring microorganism having one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory coupling 3-hydroxypropionic acid production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby the one or more gene disruptions confers stable growth-coupled production of 3-hydroxypropionic acid onto the non-naturally occurring microorganism.Type: ApplicationFiled: January 22, 2008Publication date: August 21, 2008Inventors: Anthony P. Burgard, Stephen J. Van Dien
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Publication number: 20080199942Abstract: The present invention provides methods for generating CMP-sialic acid in a non-human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided.Type: ApplicationFiled: February 6, 2008Publication date: August 21, 2008Inventor: Stephen R. Hamilton
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Publication number: 20080193969Abstract: The present invention relates to fungal host cells that are transformed with a nucleic acid construct encoding a fungal oxygen-binding proteins or fragments thereof that comprise the oxygen-binding domain. Upon transformation of the host cell with the construct, the oxygen-binding protein confers to the host cell improved fermentation characteristics as compared to untransformed host cells. These characteristics include e.g. increases in oxygen uptake rates, biomass densities, volumetric productivities and/or product yields. The invention further relates to fermentation processes in which the host cells are used and to fungal oxygen binding proteins, in particular fungal flavohemoglobins and hemoglobin domains, and to nucleotides sequences encoding these proteins.Type: ApplicationFiled: January 12, 2006Publication date: August 14, 2008Inventors: Rob Te Biesebeke, Peter Jan Punt, Cornelis Antonius Maria Jacobus Johannes Van den Hondel, Willem Meindert De Vos
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Publication number: 20080187983Abstract: The present invention provides artemisinic epoxide, and methods of synthesizing artemisinic epoxide in a genetically modified host cell. The present invention further provides methods for producing artemisinin. The present invention further provides variant enzymes that catalyze the oxidation of amorpha-4,11-diene to artemisinic epoxide; nucleic acids encoding the variant enzymes; as well as recombinant vectors and host cells comprising the nucleic acids.Type: ApplicationFiled: December 12, 2007Publication date: August 7, 2008Inventors: Jeffrey Allen DIETRICH, Yasuo Yoshikuni, Jay D. Keasling, Michelle Chia-Yu Chang
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Publication number: 20080187927Abstract: Methods are disclosed for genotoxicity testing and genoprotection testing using genetic constructs having a hydroxyurea- and UV- and gamma radiation-induced promoter linked to a reporter gene, such as green fluorescent protein.Type: ApplicationFiled: November 12, 2007Publication date: August 7, 2008Inventors: Sean P. Palecek, Michael G. Benton
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Publication number: 20080187987Abstract: The present invention relates to a composite yeast for high concentration alcohol fermentation, which includes thermostable Saccharomyces cerevisiae, acid protease, phytase, cellulose, ?-glucanase, and pectinase, and is suitable for the high concentration alcohol fermentation for various raw materials. In addition to normal fermentation, the composite yeast of the present invention can degrade the raw materials, increase the nutrient ingredients in the mash, promote the growth of yeast and provide stress tolerance protection.Type: ApplicationFiled: December 30, 2005Publication date: August 7, 2008Inventors: Xuefeng Yu, Zhihong Li, Minghua Yu, Juan Yao, Zhijun Li, Daiwu Liu
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Patent number: 7405068Abstract: Disclosed herein are glucose tolerant C2 carbon source-independent (GCSI) yeast strains having no detectable amount of pyruvate decarboxylase activity, wherein wild type yeast strains for the glucose tolerant C2 carbon source-independent yeast strains are Crabtree positive. Also disclosed are methods of selecting glucose tolerant C2 carbon source-dependent yeast strains, and methods of producing pyruvic acid or salts thereof using glucose tolerant C2 carbon source-independent yeast strain. Further disclosed herein are GCSI yeast strains having a genome that comprises an exogenous lactate dehydrogenase gene.Type: GrantFiled: April 29, 2004Date of Patent: July 29, 2008Assignee: Tate & Lyle Ingredients Americas, Inc.Inventors: Antonius Jeroen Adriaan van Maris, Jacobus Thomas Pronk, Johannes Pieter van Dijken
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Patent number: 7402415Abstract: Recombinant organisms are provided comprising genes encoding a glycerol-3-phosphate dehydrogenase and/or a glycerol-3-phosphatase activity useful for the production of glycerol from a variety of carbon substrates. The organisms further contain disruptions in the endogenous genes encoding proteins having glycerol kinase and glycerol dehydrogenase activities.Type: GrantFiled: November 18, 2005Date of Patent: July 22, 2008Assignees: E.I. du Pont de Nemours and Company, Genencor InternationalInventors: Ramesh Nair, Mark S. Payne, Donald E. Trimbur, Fernando Valle
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Publication number: 20080125487Abstract: The subject invention relates to the identification of a gene involved in the elongation of polyunsaturated fatty acids containing unsaturation at the carbon 9 position (i.e., “?9-elongase”) and to uses thereof. In particular, ?9-elongase may be utilized, for example, in the conversion of linoleic acid (LA, 18:2n-6) to eicosadienoic acid (EDA, 20:2n-6). The production of dihomo-?-linolenic acid (DGLA, 20:3n-6) from eicosadienoic acid (EDA, 20:2n-6), and arachidonic acid (AA, 20:4n-6) from dihomo-?-linolenic acid (DGLA, 20:3n-6) is then catalyzed by ?8-desaturase and ?5-desaturase, respectively. AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: November 17, 2006Publication date: May 29, 2008Inventors: Tapas Das, Pradip Mukerji, Padmavathy Krishnan, Amanda E. Leonard, Suzette L. Pereira
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Publication number: 20080090273Abstract: We disclose a recombinant yeast, wherein the yeast is pyruvate decarboxylase enzyme (PDC) activity negative (PDC-negative) and is functionally transformed with a coding region encoding a pyruvate carboxylase enzyme (PYC) wherein the PYC is active in the cytosol, a coding region encoding a malate dehydrogenase enzyme (MDH) wherein the MDH is active in the cytosol and is not inactivated in the presence of glucose, and a coding region encoding a malic acid transporter protein (MAE). We also disclose a method of producing malic acid by culturing such a yeast in a medium comprising a carbon source and a carbon dioxide source and isolating malic acid from the medium.Type: ApplicationFiled: October 31, 2006Publication date: April 17, 2008Inventors: Aaron Adriaan Winkler, Abraham Frederik de Hulster, Johannes Pieter van Dijken, Jacobus Thomas Pronk
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Patent number: 7351564Abstract: The present invention relates to a gene useful in a process to increase the microbial production of carotenoids. The carotenoids astaxanthin is distributed in a wide variety of organisms such as animals, algae and microorganisms. It has a strong antioxidation property against reactive oxygen species. Astaxanthin is used as a coloring reagent, especially in the industry of farmed fish, such as salmon, because astaxanthin imparts distinctive orange-red coloration to the animals and contributes to consumer appeal in the marketplace.Type: GrantFiled: September 23, 2003Date of Patent: April 1, 2008Assignee: DSM IP Assets B.V.Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi
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Patent number: 7297522Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to treat epilepsy. Also included are methods of making such compositions and methods of treating epilepsy.Type: GrantFiled: November 18, 2003Date of Patent: November 20, 2007Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 7285406Abstract: The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitrites to the corresponding amides, and the amidase is useful for hydrolysis of amides to the corresponding carboxylic acids. Also provided are transformed host cells containing polynucleotides for expressing the nitrile hydratase or amidase enzymes from Comamonas testosteroni 5-MGAM-4D.Type: GrantFiled: November 16, 2006Date of Patent: October 23, 2007Assignee: E.I. du Pont de Nemours and CompanyInventors: Mark S. Payne, Robert DiCosimo, John E. Gavagan, Robert D. Fallon
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Patent number: 7259001Abstract: The invention provides compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to increase secretion of male hormones or alleviate or prevent sexual disorders, e.g., impotence, in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also provided are methods of making and using these compositions.Type: GrantFiled: November 18, 2003Date of Patent: August 21, 2007Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 7252985Abstract: Novel CrtW carotenoid ketolase are provided that are useful for the production of ketocarotenoids. The ketolases genes of the present invention exhibit low homology in comparison to other CrtW ketolases previously reported. Expression of the carotenoid ketolases in heterologous hosts enabled production of canthaxanthin and astaxanthin. Coexpression experiments using divergent crtW genes resulted in increased production of the desired ketocarotenoids.Type: GrantFiled: December 17, 2004Date of Patent: August 7, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Qiong Cheng, Luan Tao, Henry Yao
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Patent number: 7198810Abstract: The present invention provides yeast belonging to the genus Saccharomyces which generates, in dough containing 5% sugar, carbon dioxide gas in an amount of not less than 2.0 ml per g of the dough and not less than 1.20 ml per ml of volume expansion of the dough at 38° C. in 60 minutes; a method of screening for the yeast; bread dough containing the yeast; a process for making bread using the yeast; and bread having an anti-mold effect which is obtained by the process.Type: GrantFiled: February 21, 2003Date of Patent: April 3, 2007Assignee: Kyowa Hakko Food Specialties Co., Ltd.Inventors: Toshiaki Imura, Hideki Kawasaki
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Patent number: 7138113Abstract: A composition is provided that includes a biologically active compound bound by a glycoprotein matrix. A method is also provided for the manufacture of a composition of the invention. The glycoprotein matrix can be formed by permitting the growth of glycoprotein producing bacteria in the presence of the active ingredient. The composition of the invention provides a method for increasing the stability and bioactivity of the active ingredient. A method is also provided for administering an active ingredient to a host by utilizing a composition of the invention.Type: GrantFiled: October 12, 2004Date of Patent: November 21, 2006Assignee: Pharmachem Laboratories, Inc.Inventor: Dilip Chokshi
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Patent number: 7135327Abstract: By using a medium containing an ingredient for activating brewer's yeast, a brewer's yeast cell body is immersed in the medium in the presence of an added inorganic salt; and the immersion is stirred at a predetermined temperature to concurrently carry out an aerobic activation treatment, resulting in the formation of a brewer's yeast cell body containing a high ribonucleic acid content comprising 10% by weight or more of ribonucleic acid based on the weight of the cell body.Type: GrantFiled: March 13, 2002Date of Patent: November 14, 2006Assignee: Sapporo Breweries LimitedInventors: Shinji Yamashita, Hisao Kado, Taiju Masuda
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Patent number: 7135308Abstract: The present invention describes a process for the production of ethanol by harvesting starch-accumulating filament-forming or colony-forming algae to form a biomass, initiating cellular decay of the biomass in a dark and anaerobic environment, fermenting the biomass in the presence of a yeast, and the isolating the ethanol produced. The present invention further relates to processing of the biomass remaining after ethanol production to recovering biodiesel starting materials and/or generation of heat and carbon dioxide via combustion.Type: GrantFiled: February 28, 2006Date of Patent: November 14, 2006Assignee: Propulsion Logic, LLCInventors: Ronnie A. Bush, Kevin M. Hall
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Patent number: 7078202Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to treat vascular dementia in a mammal. Also included are methods of making such compositions and methods of treating vascular dementia.Type: GrantFiled: November 18, 2003Date of Patent: July 18, 2006Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 7070967Abstract: A flocculent Saccharomyces cerevisae strain (BPSC-15) produces higher yields of ethanol in fermentations of fermentable sugar or fermentable starch/enzyme.Type: GrantFiled: August 19, 2004Date of Patent: July 4, 2006Assignee: Bio-Process Innovation, Inc.Inventors: M. Clark Dale, Mark Moelhman
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Patent number: 7063969Abstract: The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supereritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae. In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.Type: GrantFiled: December 13, 2000Date of Patent: June 20, 2006Assignees: Victoria University of Technology, Polychip Pharmaceuticals Pty, Ltd.Inventors: Andrew John Smallridge, Maurice Arthur Trewhella, Kylie Anne Wilkinson
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Patent number: 7045318Abstract: The invention describes methods of producing fusion proteins of albumin and growth hormone and products obtained by the methods.Type: GrantFiled: October 26, 2001Date of Patent: May 16, 2006Assignee: Delta Biotechnology LimitedInventor: David James Ballance
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Patent number: 7022513Abstract: The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In particular, the assay of the invention makes use of a cell that harbors a protein that is responsive to a cellular signal transduction pathway. The protein is operatively linked to a polypeptide which causes a detectable signal to be generated upon stimulation of the pathway, e.g., when a compound interacts with and modulates the activity of a cellular receptor or ion channel of the cell.Type: GrantFiled: July 18, 2002Date of Patent: April 4, 2006Assignee: Cadus Technologies, Inc.Inventors: Jun Xu, Joshua Trueheart
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Patent number: 6994850Abstract: The present invention provides a method for preparing a biological fertilizer composition that comprises yeast cells and swine manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor.Type: GrantFiled: July 22, 2003Date of Patent: February 7, 2006Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6979562Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to treat gastroparesis in a subject (e.g., stimulating stomach contraction, reducing abnormal gastric acid and/or pepsin production), as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using such compositions.Type: GrantFiled: November 18, 2003Date of Patent: December 27, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6979444Abstract: The present invention provides a method for preparing a biological fertilizer composition that comprises yeast cells and poultry manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor.Type: GrantFiled: July 22, 2003Date of Patent: December 27, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6977168Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to treat nephrotic syndrome (e.g., lower urinary protein and increase serum protein) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using such compositions.Type: GrantFiled: November 18, 2003Date of Patent: December 20, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6964864Abstract: The invention provides compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to ameliorate or prevent gastritis in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also provided are methods of making and using these compositions.Type: GrantFiled: November 18, 2003Date of Patent: November 15, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6942856Abstract: A composition is provided that includes a biologically active compound bound by a glycoprotein matrix. A method is also provided for the manufacture of a composition of the invention. The glycoprotein matrix can be formed by permitting the growth of glycoprotein producing bacteria in the presence of the active ingredient. The composition of the invention provides a method for increasing the stability and bioactivity of the active ingredient. A method is also provided for administering an active ingredient to a host by utilizing a composition of the invention.Type: GrantFiled: April 19, 2002Date of Patent: September 13, 2005Assignee: Pharmachem Laboratories, Inc.Inventor: Dilip Chokshi
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Patent number: 6913913Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to ameliorate renal failure (e.g., improved diuretic effect and/or lowering blood urea nitrogen, proteinuria, and/or serum creatinine levels) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using such compositions.Type: GrantFiled: November 18, 2003Date of Patent: July 5, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6913914Abstract: The invention provides compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to normalize the level of serum glutamate-pyruvate Transaminase (GPT), or reduce serum HBsAg levels in a subject, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also provided are methods of making and using these compositions.Type: GrantFiled: November 18, 2003Date of Patent: July 5, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung