Carbonyl, Ether, Aldehyde Or Ketone Containing Patents (Class 436/128)
  • Patent number: 10114013
    Abstract: The invention provides methods for rapid and quantitative extraction and detection of coenzyme Q10 in a sample readily adaptable to high throughput screening methods. The invention further provides reagents and kits for practicing the methods of the invention.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: October 30, 2018
    Assignee: Berg, LLC
    Inventors: Shen Luan, Niven Rajin Narain, Rangaprasad Sarangarajan, Nikunj Narendra Tanna
  • Patent number: 10078091
    Abstract: A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or whole blood. This method is used for new born screening for Cerebrotendinous Xanthomatosis (CTX). Methods for labeling, analyzing, and quantifying ketosterol biomarkers are also disclosed as are methods that also use mass spectrometry.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: September 18, 2018
    Assignees: DH Technologies Development Pte. Ltd., Oregon Health and Science University
    Inventors: Andrea DeBarber, Subhasish Purkayastha, Robert D. Steiner, Michal Weinstock
  • Patent number: 9494495
    Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: November 15, 2016
    Assignee: PULSE HEALTH LLC
    Inventors: Steve Cooper, Neal Andrews, Maura Mahon, Rachel Dreilinger, David Barsic, Weston Myler, Martin Krauss, Scot Herbst, James Ingle, Gerald Thomas, Rick Myers, Brian Young, Juven Lara, Charles Noll
  • Patent number: 9493489
    Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: November 15, 2016
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Robert Jacobs, Matthew Orr, Stephen Wring, Daitao Chen, Huchen Zhou, Dazhong Ding, Yiqing Feng, Long Yi, Vincent S. Hernandez, Yong-Kang Zhang, Jacob J. Plattner
  • Patent number: 9360454
    Abstract: The invention provides methods for rapid and quantitative extraction and detection of coenzyme Q10 in a sample readily adaptable to high throughput screening methods. The invention further provides reagents and kits for practicing the methods of the invention.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: June 7, 2016
    Assignee: Berg LLC
    Inventors: Shen Luan, Niven Rajin Narain, Rangaprasad Sarangarajan, Nikunj Narendra Tanna
  • Patent number: 9303046
    Abstract: The present invention is directed to a process for the preparation of heterocyclic ester derivatives of formula I wherein A1, SEM, and W1 are as defined herein. Such compounds are useful as intermediates in the synthesis of derivatives useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: April 5, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jean-Pierre André Marc Bongartz, Alfred Elisabeth Stappers, Christopher A. Teleha, Koen Johan Herman Weerts, Kenneth J. Wilson
  • Patent number: 9194806
    Abstract: A means for detecting active oxygen in the human body, which quantitatively detects the amount of active oxygen remaining in the body by applying urine to a detection paper, and is characterized by providing a means for detecting active oxygen in the human body, which detects the amount of active oxygen by submerging a test strip into urine, on which has been applied a color indicating agent that changes color by reacting with malondialdehyde (MDA) and to which has been coupled a support stick, and observing color change. The present invention can affordably and simply identify active oxygen, because the test strip changes color when simply wetted with urine and the test does not require additional technically skilled laboratory staff or expensive equipment. Also, the invention enables simple testing regardless of time and space since a specific facility is unnecessary for the test, thereby providing another advantage of general usage.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: November 24, 2015
    Assignee: DFI CO., LTD.
    Inventors: Jung-geon Yun, Yong-ae Park, Tae-wan Kim, Sang-hoon Kang
  • Publication number: 20150132857
    Abstract: A device for detecting airborne contaminants includes a protonated, electrically conductive sensing material with affinity for binding with, and capable of being deprotonated by, the airborne contaminant. Electronics measure a property of the sensing material that is sensitive to deprotonation and generates signals indicative of the airborne contaminant. A method for detecting airborne contaminants includes: determining a property change of the protonated, electrically conductive material; and determining presence of the airborne contaminant based on the change.
    Type: Application
    Filed: June 13, 2013
    Publication date: May 14, 2015
    Inventors: Joseph J. Belbruno, Susanne E. Tanski
  • Patent number: 8986998
    Abstract: Disclosed herein is a method for identifying the compounds contributing to a pungent odor from an air conditioner, a method for artificially reproducing the pungent odor, and preparing a corresponding pungent odor composition. Through the analysis method of the present invention, the compounds contributing to the pungent odor from an air conditioner may be identified and quantified. The pungent odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced pungent odor may provide significant data required for development of an apparatus and a method for removing specific odors.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 24, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim
  • Publication number: 20150065365
    Abstract: An apparatus is provided for sensing an analyte in a fluid.
    Type: Application
    Filed: May 12, 2014
    Publication date: March 5, 2015
    Applicant: Invoy Technologies, L.L.C
    Inventor: Lubna Ahmad
  • Patent number: 8969084
    Abstract: A method that identifies the compounds contributing to a sweet odor from an air conditioner, reproduces the sweet odor, and prepares a corresponding sweet odor composition. Through the analysis method of the present invention, the compounds contributing to the sweet odor from an air conditioner are identified and quantified. The sweet odor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced sweet odor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: March 3, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Seok Man Kim, Sang Jun Lee
  • Patent number: 8969083
    Abstract: A method that identifies the compounds contributing to a fish-like odor from an air conditioner and artificially reproduces the fish-like odor, and prepares a corresponding fish-like odor composition. Through the analysis method of the present invention, the compounds contributing to the fish-like odor from an air conditioner are identified and quantified. The fish-like odor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced fish-like odor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: March 3, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Sang Jun Lee, Seok Man Kim
  • Patent number: 8962334
    Abstract: A method is provided that identifies the compounds contributing to a malodor from an air conditioner, reproduces the malodor, and prepares a corresponding malodor composition. Through the analysis method of the present invention, the compounds contributing to the malodor from an air conditioner are identified and quantified. The malodor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced malodor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: February 24, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Chi Won Jeong, Ji Wan Kim, Sun Dong Kim, Sang Jun Lee, Seok Man Kim
  • Publication number: 20150051111
    Abstract: A method is described for mass spectrometric analysis of a sample comprising phenolic OH, such as a steroid comprising a phenolic OH, using a quaternary amino oxy Cookson (QAOC) reagent. The QAOC reagent can improve ionization and fragmentation properties of phenolic OH samples, which can thereby improve quantitation and identification. The method can include derivatizing the phenolic OH sample with the QAOC reagent to create an adduct and analyzing the adduct using mass spectrometry. Derivatization of the sample can be a one-step reaction where the QAOC reagent comprises an aminooxy MS tag or can be a multi-step reaction, where the adduct is formed by the reaction of carbonyl substituted PTAD based reagent and the sample followed by combination with an aminooxy MS tag. The sample can also be enriched prior to reacting it with the reagent. The method can also allow for multiplexing.
    Type: Application
    Filed: January 16, 2013
    Publication date: February 19, 2015
    Inventors: Subhakar Dey, Subhasish Purkayastha
  • Patent number: 8945935
    Abstract: The present invention provides a system and method for diagnosing, monitoring or prognosing Multiple Sclerosis at different stages as well as affording the prediction of disease activity and response to a treatment regimen, using at least one sensor comprising carbon nanotubes or metal nanoparticles, each coated with various organic coatings in conjunction with a pattern recognition algorithm.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: February 3, 2015
    Assignees: Technion Research & Development Foundation Ltd., Mor Research Applications Ltd., Rappaport Family Institute for Research in the Medical Sciences
    Inventors: Hossam Haick, Ariel Miller
  • Publication number: 20150031582
    Abstract: A method comprising (a) obtaining one or more biological samples from a subject wherein the subject has undergone an organ transplant; (b) determining the amount and type of one or more volatile organic compounds in the biological sample; and (c) correlating the amount of volatile organic compounds to a degree of transplant rejection. A device comprising a plurality of sensors configured to detect a plurality of volatile organic compounds in a biological sample of a subject having undergone an organ transplant.
    Type: Application
    Filed: July 28, 2014
    Publication date: January 29, 2015
    Applicant: UNIVERSITY OF HOUSTON SYSTEM
    Inventors: Dong Cai, Zhifeng Ren, Xian C. Li, Renard L. Thomas
  • Publication number: 20150031141
    Abstract: This invention relates to the preparation and making use of a catalyst for the photo-catalytic degradation of methyl tertiary butyl ether (MTBE) in water. Palladium doped on composite Cerium oxide-zinc oxide (Ce2O3—ZnO) photo-catalyst was prepared by wetness incipient impregnation method. This catalyst composition demonstrated 99.6% degradation of MTBE at room temperature in a photo catalytic reaction conducted in oxygen saturated aqueous medium in the presence of UV light.
    Type: Application
    Filed: July 24, 2013
    Publication date: January 29, 2015
    Inventors: Zaki S. Seddigi, SALEH A. SALEH
  • Publication number: 20150031140
    Abstract: The present disclosure relates to a novel photocatalyst composition and a process of using the photocatalyst for the photocatalytic degradation of methyl tertiary-butyl ether (MTBE) in water. Palladium doped nano zinc oxide photocatalyst was prepared by zinc nitrate hexahydrate and an ammonium carbonate and the photocatalyst composition demonstrated more than 90-99% degradation of MTBE at room temperatures in a photo catalytic reaction conducted in an oxygen saturated aqueous medium.
    Type: Application
    Filed: July 24, 2013
    Publication date: January 29, 2015
    Inventors: Zaki S. Seddigi, SALEH A. SALEH
  • Publication number: 20140377877
    Abstract: A portable electronic device comprises a chemical sensor that is sensitive to a concentration of a chemical analyte and at least two auxiliary sensors that are sensitive to parameters that are different from the concentration of the chemical analyte. The portable electronic device comprises a control device that receives signals from the chemical sensor and from the auxiliary sensors at a plurality of points in time distributed over a measurement period and correlates the time dependencies of these signals to obtain a corrected reading of the first chemical sensor. The portable electronic device may be employed for breath analysis.
    Type: Application
    Filed: June 20, 2014
    Publication date: December 25, 2014
    Inventors: Lukas BÜRGI, Felix MAYER, Samuel WEHRLI
  • Patent number: 8916385
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: December 23, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Mildred M. Goldman, Nigel J. Clarke, Richard E. Reitz
  • Publication number: 20140356972
    Abstract: An apparatus for estimating the concentration of an aldehyde comprising a solid medium; a nucleophilic aromatic compound held on the medium; and an acid held on the medium and a method for detecting the presence of an aldehyde in a sample with the apparatus in which the sample is exposed at room temperature to a test medium to catalyze the formation of optically detectable quantities of a product within a time period of no more than 60 minutes and without applying any external heat to the sample or test medium, the test medium comprising a indicator that is a nucleophilic compound having acidic protons at the nucleophilic center and at least one acid, and measuring the optical changes that occur as a result of the catalysis.
    Type: Application
    Filed: August 20, 2014
    Publication date: December 4, 2014
    Inventors: Enrique Martinez, II, Denis Callewaert, Donald J. VerLee
  • Publication number: 20140349326
    Abstract: Apparatus and methods are provided for analyzing a medical condition of a user. The apparatus may include a user interface configured to receive user identification information inputted by the user, an analyzer, and a processor all disposed within a common housing. The analyzer is configured to receive a biological specimen from the user and to analyze the biological specimen to generate analysis information. The processor is configured to store and forward the analysis information and to receive prescription information. The apparatus may include a communication unit configured to transmit the user identification information and the analysis information to a doctor at a remote location for review and to receive the prescription information from the doctor. The apparatus then may dispense the prescribed medication or print a medication prescription.
    Type: Application
    Filed: February 6, 2013
    Publication date: November 27, 2014
    Inventor: Michael INGBER
  • Publication number: 20140349885
    Abstract: A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological matrices. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: December 6, 2012
    Publication date: November 27, 2014
    Inventors: Subhakar Dey, Subhasish Purkayastha
  • Patent number: 8883512
    Abstract: A serum-based biomarker for diagnosing gestational diabetes, preeclampsia and fetal growth restriction (GDM-PREEC-FGR), based on retinoid profiling, and a method for diagnosing GDM-PREEC-FGR that specifically uses a blood sample to identify and measure the concentrations of retinol (vitamin A alcohol), retinyl esters and retinoic acid.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: November 11, 2014
    Inventor: Anthony R. Mawson
  • Patent number: 8871519
    Abstract: The present invention relates to methods for qualifying material for using in the cleaning of alkylene oxide equipment. Qualified material is not expected to contribute to the formation of determinable amounts of alkylene oxide by-products. Methods of cleaning alkylene oxide equipment, and alkylene oxide processes incorporating these methods are also provided.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: October 28, 2014
    Assignee: Dow Technology Investments LLC
    Inventor: Paul Victor Hinman
  • Patent number: 8871438
    Abstract: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: October 28, 2014
    Assignee: Korea Research Institute of Standards and Science
    Inventors: Tae Geol Lee, Dae Won Moon, Byong Chul Yoo, In Hoo Kim
  • Patent number: 8871521
    Abstract: Ketoacidosis is an extreme and uncontrolled form of ketosis, which is a normal response to prolonged fasting. Embodiments of this invention test the ketone level of a patient by measuring the ketone bodies in breath condensation. Some embodiments include a device for medical testing comprising a hollow container, comprising powder mixture of sodium nitroferricyanide, ammonium sulfate and silica and a liquid including an ammonium hydroxide solution.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: October 28, 2014
    Assignee: Akers Biosciences, Inc.
    Inventor: Raymond F. Akers, Jr.
  • Patent number: 8852946
    Abstract: Disclosed herein is a method for identifying the compounds contributing to urine odor emitting from an air conditioner, a method for artificially reproducing the detected urine odor, and preparing a corresponding urine odor composition. Through the analysis method of the present invention, the compounds contributing to the urine odor emitted from an air conditioner may be identified and quantified. The detected urine odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced urine odor may provide meaningful data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: October 7, 2014
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Seok Man Kim
  • Patent number: 8852945
    Abstract: Disclosed herein is a method for identifying compounds contributing to a sour odor emitting from an air conditioner, a method for artificially reproducing the detected sour odor and preparing a corresponding sour odor composition. Through the analysis method of the present invention, the compounds contributing to the sour odor emitted from an air conditioner may be identified and quantified. The detected sour odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced sour odor may provide meaningful data required for development of an apparatus and a method for removing specific odors.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 7, 2014
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim
  • Patent number: 8846405
    Abstract: A method for detecting the presence of an aldehyde in a sample comprises steps of exposing the sample at room temperature to a test medium to catalyze the formation of optically detectable quantities of a product within a time period of no more than 60 minutes and without applying any external heat to the sample or test medium, the test medium comprising a indicator that is a nucleophilic compound having acidic protons at the nucleophilic center and at least one acid, and measuring the optical changes that occur as a result of the catalysis.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: September 30, 2014
    Assignee: Oxford Biomedical Research, Inc.
    Inventors: Enrique Martinez, II, Denis Callewaert, Donald J. VerLee
  • Patent number: 8815605
    Abstract: The invention relates to methods and kits for determining the total organic acid content in a coolant sample.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: August 26, 2014
    Assignee: Dexsil Corporation
    Inventors: Theodore B. Lynn, Timothy D. Lynn
  • Patent number: 8785204
    Abstract: The invention provides a method of assaying for tetrahydrocannabinol in a body fluid. The method includes contacting a sample of body fluid with an imine capable of reacting with tetrahydrocannabinol to yield a quinone imine, and detecting the formation of a quinone imine, where the sample is contacted with the reagent compound at a pH of at least 10.5.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: July 22, 2014
    Assignee: Oxtox Limited
    Inventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
  • Patent number: 8778693
    Abstract: A subject of the invention is a kit for the identification, characterization and quantification by a single detection of the carboxylic, thiol and amine functional groups contained in a sample.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: July 15, 2014
    Assignees: Universite d'Aix Marseille, Centre National de la Recherche Scientifique
    Inventors: Jean-Luc Boudenne, Bruno Coulomb, Fabien Robert-Peillard, Edwin Barco Palacio
  • Publication number: 20140186964
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
    Type: Application
    Filed: January 10, 2014
    Publication date: July 3, 2014
    Applicant: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Tilmann B. Walk, Ralf Looser, Edgar Leibold, Hennicke Kamp, Georgia Coelho Palermo Cunha, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine
  • Patent number: 8759111
    Abstract: Porous sol-gel material essentially consisting of units of one or more first polyalkoxysilanes chosen from the following compounds: (chloromethyl)triethoxysilane; 1,3-dimethyltetramethoxydisiloxane; ethyl trimethoxysilane; triethoxy(ethyl)silane; triethoxymethylsilane; triethoxy(vinyl)silane; trimethoxymethylsilane; trimethoxy(vinyl)silane; tetraethoxysilane or tetramethoxysilane (TMOS) and of units of one or more second polyalkoxysilanes chosen from the following compounds: (N-(3-(trimethoxysilyl)propyl)ethylenediamine; 3-aminopropyltriethoxysilane (APTES) and 3-aminopropyltrimethoxysilane, in a first polyalkoxysilane/second polyalkoxysilane molar ratio of 1/0.01 to 1/1, optionally comprising a probe molecule, method of preparation and applications in the trapping of monocyclic aromatic hydrocarbons and other pollutants or in their detection.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: June 24, 2014
    Assignees: CEA—Commisariat a l'Energie Atomique et aux Energies Alternatives, CNRS—Centre National de la Recherche Scientifique
    Inventors: Sabine Crunaire, Thu-Hoa Tran-Thi
  • Publication number: 20140147926
    Abstract: This invention relates to a method of analyzing an aldehyde compound in a metal plating solution, including adding a pH control solution to an aldehyde derivative, thus preparing an oversaturated aldehyde derivative solution in which the aldehyde derivative is dissolved to be oversaturated while the pH of the aldehyde derivative solution is adjusted to be the same as that of the metal plating solution; adding the oversaturated aldehyde derivative solution to the metal plating solution, so that the aldehyde compound which is present in the metal plating solution undergoes derivation, thus obtaining an aldehyde derivative compound; extracting the aldehyde derivative compound; and analyzing the aldehyde compound from the extracted aldehyde derivative compound.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 29, 2014
    Applicant: SAMSUNG ELECTRO-MECHANICS CO., LTD.
    Inventors: Ji Eun Jeon, Se Kyung Lee, Hyo Jin Yoon, Suk Jin Ham
  • Patent number: 8728824
    Abstract: The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: May 20, 2014
    Assignee: Quest Diagnostics Investments Inc.
    Inventor: Scott Goldman
  • Patent number: 8697450
    Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: April 15, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Blas Cerda, Alex Cherkasskiy
  • Patent number: 8685739
    Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: April 1, 2014
    Inventors: Carolyn Slupsky, Thomas Marrie
  • Publication number: 20140038302
    Abstract: The invention provides methods for rapid and quantitative extraction and detection of coenzyme Q10 in a sample readily adaptable to high throughput screening methods. The invention further provides reagents and kits for practicing the methods of the invention.
    Type: Application
    Filed: March 1, 2013
    Publication date: February 6, 2014
    Applicant: BERG DIAGNOSTICS
    Inventor: BERG DIAGNOSTICS
  • Publication number: 20140017800
    Abstract: A method for detecting the presence of an aldehyde in a sample comprises steps of exposing the sample at room temperature to a test medium to catalyze the formation of optically detectable quantities of a product within a time period of no more than 60 minutes and without applying any external heat to the sample or test medium, the test medium comprising a indicator that is a nucleophilic compound having acidic protons at the nucleophilic center and at least one acid, and measuring the optical changes that occur as a result of the catalysis.
    Type: Application
    Filed: July 16, 2012
    Publication date: January 16, 2014
    Inventors: Enrique Martinez II, Denis Callewaert, Donald J. VerLee
  • Publication number: 20140004616
    Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: May 20, 2013
    Publication date: January 2, 2014
    Applicant: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Sasi Pillal, Brian L. Williamson, Subhasish Purkayastha, Michal Weinstock
  • Patent number: 8617898
    Abstract: Quantification of vitamin D2, vitamin D3, and the monohydroxy and diihydroxy metabolites of vitamin D2 and vitamin D3, can comprise labeling analytes with mass spectrometry (MS) tagging reagents and performing LC-MSMS analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses. Under high energy collisions, reporter groups can be generated. The intensity or the peak area detected for each reporter group can be used for quantitation. In some embodiments, a one-step tagging reagent is used that is a dienophile-containing, labeled Diels Alder reagent.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: December 31, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Sasi K. Pillai, Brian Williamson, Subhasish Purkayastha
  • Publication number: 20130337568
    Abstract: The invention is directed towards methods and compositions for identifying the presence of surfactants in water. The invention is quite superior over the prior art because it can form a colorful complex in half the time, avoid the need for difficult separation steps, use a safer solvent and avoid the formation of messy foam. The invention involves adding to the water a cobalt thiocyanate reagent, pre-prepared from a cobalt salt and a thiocyanate salt, which forms a colorful complex with the surfactant. Chloroform is then added to the water. The cobalt reagent causes the virtually all of the surfactant to form a colored complex which rapidly migrates into the chloroform and prevents the surfactant from foaming. Once in the chloroform, a UV-vis spectrometer can easily and precisely identify the type and amount of surfactant that was in the water.
    Type: Application
    Filed: June 18, 2012
    Publication date: December 19, 2013
    Inventors: Viviane Pacheco e Silva, Luiz Wanderley Bratfisch Pace, Edmir Carone, JR.
  • Patent number: 8609428
    Abstract: The invention relates to an assay to test for pyrethroids in a sample. The assay is particularly useful for testing material treated with pyrethroids, such as bed netting and the like.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: December 17, 2013
    Assignee: London School of Hygiene & Tropical Medicine
    Inventors: Harparkash Kaur, Teunis Eggelte
  • Patent number: 8586365
    Abstract: The invention provides novel methods for optimizing the design of a fatty acid alkyl ester-containing biofuel (e.g. a biodiesel, a biodiesel blend, or a jet biofuel) and for identifying a fatty acid alkyl ester-containing biofuel's feedstock.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: November 19, 2013
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Paul P. Wells, Mike T. Noorman, Donna I. Hoel, Jacob J. Habeeb
  • Publication number: 20130217136
    Abstract: An improved qualitative or semi-quantitative diagnostic test for low levels of any analyte, such as hCG, in a biological sample, such as urine. The test comprises of a test device containing reagents for the detection of the monitored analyte and an electronic reader that measures color development at a detection area of the device. The color development is converted to an electronic or digital signal. Improvements were made to the detection process to optimize the detection of a valid fluid front, increase the detection limit without compromising the reliability and accuracy of the test system, and improve the determination of test result validity.
    Type: Application
    Filed: February 22, 2012
    Publication date: August 22, 2013
    Applicant: CHURCH & DWIGHT CO., INC.
    Inventors: Albert R. Nazareth, Andy Sturman, Benedict Zin
  • Patent number: 8481324
    Abstract: The present invention provides a system containing an array of chemically sensitive sensors based on coated single walled carbon nanotubes, for measuring volatile organic compounds indicative of renal failure. Methods of breath analysis for diagnosing chronic, acute and end-stage renal failure are disclosed.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 9, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Hossam Haick, Zaid Abassi, Farid Nakhoul
  • Patent number: 8476075
    Abstract: A method of estimating the amount of unreacted starting materials (glycerides, methyl esters, etc.) and the composition of a biodiesel using TLC in conjunction with a lipophilic dye, Nile Red is described herein. The dye based TLC method of the present invention is convenient and provides significant advantages over existing methods for estimating the purity of a biodiesel composition.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 2, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eva Deemer, Wen Yee Lee, Xiomara Carolina Chianelli
  • Patent number: 8470602
    Abstract: Disclosed are methods and systems for the analysis of delta 5 steroid compounds in a sample using supported liquid extraction and liquid chromatography/mass spectrometry.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: June 25, 2013
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Donald Walt Chandler, Russell Philip Grant, Samuel Meares, Patricia Holland