The Hetero Ring Has 8 Or More Ring Carbons Patents (Class 514/28)
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Patent number: 8871727Abstract: Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 16, 2010Date of Patent: October 28, 2014Assignee: Eli Lilly and CompanyInventors: Jeffery Alan Meyer, William Hunter White, Joseph Raymond Winkle
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Publication number: 20140315840Abstract: Insect controlling compositions including an N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximine compound exhibiting increased stability, along with methods for preparing same, are disclosed.Type: ApplicationFiled: July 1, 2014Publication date: October 23, 2014Inventors: Kuide Qin, Raymond E. Boucher, Jr.
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Publication number: 20140315839Abstract: Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula (I), Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].Type: ApplicationFiled: July 1, 2014Publication date: October 23, 2014Applicant: MEIJI SEIKA PHARMA CO., LTD.Inventors: Ryo HORIKOSHI, Yasumichi ONOZAKI, Satoshi NAKAMURA, Masahiro NOMURA, Makoto MATSUMURA, Masaaki MITOMI
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Publication number: 20140315838Abstract: The present invention relates to methods of treating a recurring gastrointestinal (GI) infection of Clostridium difficile in a subject comprising administering to the subject an effective amount of the compounds of the present invention.Type: ApplicationFiled: June 28, 2013Publication date: October 23, 2014Applicant: Optimer Pharmaceuticals, Inc.Inventors: Youe-Kong Shue, Sherwood Gorbach, Pamela Sears
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Patent number: 8859510Abstract: The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.Type: GrantFiled: January 22, 2008Date of Patent: October 14, 2014Assignee: Optimer Pharmaceuticals, Inc.Inventors: Yu-Hung Chiu, Tessie Mary Che, Alex Romero, Yoshi Ichikawa, Youe-Kong Shue
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Patent number: 8858967Abstract: Pharmaceutical cream-gel compositions useful for the treatment of a variety of dermatological conditions, disorders and afflictions, in particular of rosacea, contain at least one avermectin compound active principle, and which also contain an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier, the oily phase comprising oils having a melting point below 30° C. and being free of solid fats having a melting point above 30° C., formulated into a physiologically acceptable medium therefor.Type: GrantFiled: September 18, 2006Date of Patent: October 14, 2014Assignee: Galderma S.A.Inventors: Fanny Astruc, Sandrine Orsoni, Laurent Fredon
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Publication number: 20140303104Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient. The at least one co-ingredient may include at least one metal oxide, a combination of at least transition metal salt and at least one proteinaceous material or a combination of at least one proteinaceous material and at least one polymeric material. The method further includes spray drying the liquid composition to provide a solid composition. In one aspect of this embodiment, the solid composition provided by the spray drying exhibits enhanced pesticidal activity compared to the liquid composition.Type: ApplicationFiled: June 19, 2014Publication date: October 9, 2014Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, JR., James E. Dripps, Margaret S. Kempe, Martin C. Logan, Douglas J. Linscott, John M. Atkinson
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Patent number: 8841322Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.Type: GrantFiled: April 22, 2013Date of Patent: September 23, 2014Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Jian-Qiang Fan, Satoshi Ishii, Naoki Asano
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Publication number: 20140274687Abstract: Canola seed treated with spinosad controls flea beetle.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: Dow AgroSciences LLCInventors: William H. Hendrix, III, Gary C. Turnbull
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Publication number: 20140274686Abstract: Canola seed treated with spinetoram controls flea beetle.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: Dow AgroSciences LLCInventors: William H. Hendrix, III, Gary C. Turnbull
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Publication number: 20140235442Abstract: A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and an insecticide compound (b) in a (a)/(b) weight ratio of from 1/1000 to 1000/1. A composition further comprising an additional fungicidal compound. A method for preventively or curatively combating the pests and diseases of crops by using this composition.Type: ApplicationFiled: April 25, 2014Publication date: August 21, 2014Inventors: Heike HUNGENBERG, Gilbert LABOURDETTE, Albert SCHIRRING, Burkhard SCHUETZ, Anne SUTY-HEINZE, Wolfgang THIELERT, Martin VAUPEL
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Publication number: 20140221298Abstract: The present invention provides an agricultural and horticultural fungicidal composition including a compound A which is at least one selected from a nitrogen-containing heterocyclic compound having a specific structure including a compound represented by the formula (1), and a salt thereof, and a compound B which is at least one selected from the group of specific pesticidally active compounds: in the formula (1), X each independently represents a halogeno group or a C1 to 6 alkyl group; n represents the number of X(s) and is an integer of 0 to 6; and X? represents a halogeno group; and R1, R2 and R3 each independently represent a C1 to 6 alkyl group or a hydroxyl group.Type: ApplicationFiled: September 24, 2012Publication date: August 7, 2014Inventor: Raito Kuwahara
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Publication number: 20140221201Abstract: The present invention relates to pesticidal mixtures comprising as active compounds 1) at least one pesticidal active 3-arylquinazolin-4-one compound I of formula (I): wherein R1, R2, R3, R4, k and n are defined in the description; and 2) at least one active compound II selected from a group M comprising acteylcholine esterase inhibitors, GABA-gated chloride channel antagonists, sodium channel modulators, nicotinic acteylcholine receptor agonists/antagonists, allosteric nicotinic acetylcholine receptor activators, chloride channel activators, juvenile hormone mimics, homopteran feeding blockers, mit grow inhibitors, inhibitors of mitochondrial bATP synthase, uncouplers of the oxidative phosphorylation, inhibitors of the chitin biosynthesis, moulting disruptors, ecdyson receptor agonists, octamin receptor agonists, inhibitors of the MET, voltage-dependent sodium channel blockers, inhibitors of the lipid synthesis, ryanodine receptor modulators and other compounds as defined in the description, in syneType: ApplicationFiled: August 30, 2012Publication date: August 7, 2014Applicant: BASF SEInventors: Florian Kaiser, Steffen Groß, Jürgen Langewald, Arun Narine
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Patent number: 8796433Abstract: The present invention provides compositions, systems and methods for demulsifying an emulsion including an aqueous phase and an organic phase by adding an effective amount of a composition comprising at least one quaternary organopolysiloxane or salt thereof to the emulsion, the composition optionally including at least one of quaternary epihalohydrin/polyamine copolymers or salts, and/or (poly)diallyldimethylammonium halides.Type: GrantFiled: September 5, 2012Date of Patent: August 5, 2014Assignees: Kroff Chemical Company, Dow Agrosciences LLCInventors: Paul Rey, David M. Sunderlik, Steven P. Ceplecha
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Patent number: 8796231Abstract: Disclosed is a pest control composition having an excellent controlling effect on pests, which comprises etoxazole and a compound represented by the formula (I): wherein, R1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, R3 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, R4 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, R5 is a hydrogen atom, a C1-C4 alkyl group, or a C1-C4 alkylamino group, R6 is a hydrogen atom or a methyl group, R7 is a methyl group or an ethyl group, R8 is an amino group, a C1-C4 alkylamino group, or a di(C1-C4 alkyl)amino group, and X1 and X2 are hydrogen atoms or X1 and X2 together form a single bond.Type: GrantFiled: February 18, 2011Date of Patent: August 5, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Yasutaka Shimokawatoko, Katsuya Natsuhara, Tetsuo Tanikawa
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Patent number: 8796230Abstract: A method for reducing alcohol consumption in a subject includes a step of identifying a subject exhibiting at least one symptom of alcoholism and then administering a therapeutically effective amount of an Ivermectin analogue-containing composition to the subject. A method of screening Ivermectin analogues for reducing alcohol consumption is also provided.Type: GrantFiled: January 21, 2011Date of Patent: August 5, 2014Assignee: University of Southern CaliforniaInventors: Daryl L. Davies, Ronald L. Alkana, Liana Asatryan, Daya I. Perkins, Maya S. Popova
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Patent number: 8785372Abstract: Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R8 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.Type: GrantFiled: May 15, 2013Date of Patent: July 22, 2014Assignee: Aventis AgricultureInventors: Hyoung Ik Lee, Loic Patrick Le Hir de Fallois, Philip Reid Timmons, William Glenn Cawthorne, Adalberto Perez de Leon
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Patent number: 8778895Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, cyclic ketoenols or other acaricidally active compounds and, secondly, further insecticidally active compounds from the group of the anthranilamides, which combinations are highly suitable for controlling animal pests, such as insects and unwanted acarids.Type: GrantFiled: March 9, 2010Date of Patent: July 15, 2014Assignee: Bayer Intellectual Property GmbHInventors: Christian Funke, Thomas Bretscheneider, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Anton Kraus
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Patent number: 8778835Abstract: A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and an insecticide compound (b) in a (a)/(b) weight ratio of from 1/1000 to 1000/1. A composition further comprising an additional fungicidal compound. A method for preventively or curatively combating the pests and diseases of crops by using this composition.Type: GrantFiled: July 5, 2007Date of Patent: July 15, 2014Assignee: Bayer Cropscience AGInventors: Heike Hungenberg, Gilbert Labourdette, Albert Schirring, Burkhard Schuetz, Anne Suty-Heinze, Wolfgang Thielert, Martin Vaupel
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Publication number: 20140194374Abstract: A new method of controlling worm burden in ruminants by using two different injectable anthelmintics at or about the same time to increase the time between treatments and to rely on the animal's immune response. One of the anthelmintics is a long acting formulation capable of providing a sustained release of abamectin or other macrocyclic lactone for 2-14 days, to enable the anthelmintic to remove or kill incoming larvae for a sufficiently long period of time to allow the host to recognise the incoming larvae as foreign, and thus allow the ruminant to mount an immune response against these incoming larvae. The other is a short acting anthelmintic such as levamisole designed to substantially eliminate the initial parasite population of adults, juveniles and larvae. They can be combined into a single injectable formulation with a high percentage of levamisole (preferably over 30% of the formulation w/v) together with about 1% w/v of a macrocyclic lactone such as abamectin, dissolved in glycerol formal.Type: ApplicationFiled: August 14, 2012Publication date: July 10, 2014Applicant: VIRBACInventors: Nicola Jane Cuff, Peter Norman Pulford, Mark Colin Vickers
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Publication number: 20140179623Abstract: The present application relates to active compound combinations of pyrazin-2-ylpyrazoles (component A) with at least one further ectoparasiticide or synergists (component B), and to products comprising such active compound combinations. These active compound combinations are suitable for controlling animal pests in the field of veterinary medicine.Type: ApplicationFiled: December 19, 2011Publication date: June 26, 2014Applicant: Bayer Intellectual Property GmbHInventors: Andreas Turberg, Ulrich Görgens, Hans-Georg Schwarz, Stefan Werner
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Publication number: 20140142054Abstract: Disclosed is an arthropod pest control composition having an excellent controlling effect on arthropod pests, which comprises an amide compound represented by formula (a), a spinosin compound represented by formula (1), wherein R1, R2, X1, X2 are defined in the present claims, and one or more compounds selected from Group (A), consisting of fipronil, pymetrozine, a compound represented by formula (b) and a neonicotinoid compound containing a nitroguanidine structure.Type: ApplicationFiled: July 12, 2012Publication date: May 22, 2014Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Masaomi Ogawa, Yukie Hirotomi
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Publication number: 20140135280Abstract: Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: November 7, 2013Publication date: May 15, 2014Applicant: Eli Lilly and CompanyInventor: Joseph Raymond Winkle
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Patent number: 8722863Abstract: The present invention provides solid state forms of Fidaxomycin, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising one or more of the solid state forms of Fidaxomycin, and processes for the preparation of the compositions and formulations. The solid state forms of the present invention exhibit advantageous properties such as improved reliability and reproducibility in manufacturing and processing and stability in formulations.Type: GrantFiled: May 17, 2013Date of Patent: May 13, 2014Assignee: Teva Pharmaceutical Works Ltd.Inventors: Tamas Fonagy, Adrienne Kovacsne-Mezei, Levente Szuros, Edit Nagyne Arvai
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Patent number: 8722636Abstract: Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of a immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said compositon dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal.Type: GrantFiled: January 4, 2012Date of Patent: May 13, 2014Assignee: New Market Pharmaceuticals, LLCInventors: David Rock, Mark Ridall
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Publication number: 20140128334Abstract: The present invention provides solid state forms of Fidaxomycin, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising one or more of the solid state forms of Fidaxomycin, and processes for the preparation of the compositions and formulations. The solid state forms of the present invention exhibit advantageous properties such as improved reliability and reproducibility in manufacturing and processing and stability in formulations.Type: ApplicationFiled: October 31, 2013Publication date: May 8, 2014Applicant: Teva Pharmaceutical Works Ltd.Inventors: Tamas FONAGY, Adrienne KOVACSNE-MEZEI, Levente SZUROS, Edit Nagyne ARVAI
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Publication number: 20140107054Abstract: A method of treating a disease or disorder caused by the presence of a bacterium selected from the group consisting Clostridium species, Staphylococcus species, Enterococcus species and combinations thereof comprising administering to a patient in need an effective amount of a mixture, which comprises tiacumicin B, lipiarmycin A4, and at least one of other macrocyclic compounds:Type: ApplicationFiled: December 21, 2012Publication date: April 17, 2014Applicant: OPTIMER PHARMACEUTICALS, INC.Inventor: Optimer Pharmaceuticals, Inc.
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Patent number: 8697602Abstract: A method of controlling pests in crops of transgenic useful plants or propagation material thereof, characterized in that a pesticidal composition comprising a macrolide compound in free form or in agrochemically useful salt form as active ingredient and at least one auxiliary is applied to the pests or their environment.Type: GrantFiled: May 17, 2011Date of Patent: April 15, 2014Assignee: Syngenta Crop Protection, LLCInventors: Dieter Hofer, Marius Sutter, Franz Brandl, Bruce Lee, Roger Graham Hall, Max Angst
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Patent number: 8697661Abstract: The present invention relates to the use of spinosyns and spinosyn compositions as pharmaceuticals and methods for treatment—including prevention—of protozoan infections and/or disorders relating to a protozoan infection, such as malaria and leishmania, viral infections such as Herpes Simplex virus and Influenza virus and neoplastic disorders or cancer. Advantageously, compositions of the invention inhibit protozoan, virus growth and neoplastic cell proliferation with only minimal or no disruption or harm to the host which may be an animal or human.Type: GrantFiled: June 23, 2010Date of Patent: April 15, 2014Assignees: Entarco SAInventor: Christine Kritikou
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Publication number: 20140080777Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.Type: ApplicationFiled: November 18, 2013Publication date: March 20, 2014Applicant: DOW AGROSCIENCES LLCInventors: Lesley S. Burns, Paul Richard Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barnie Wilkinson
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Patent number: 8673934Abstract: The invention refers to agents for the preventive therapy after acute stroke, in particular having the aim to prevent infections after stroke. The agents inventively employed in pharmaceutical preparations are anti-infective agents and/or immunomodulating agents, e.g. cytokines and/or inhibitors of the SNS.Type: GrantFiled: March 5, 2003Date of Patent: March 18, 2014Inventors: Andreas Meisel, Konstantin Prass, Christian Meisel, Elke Halle, Ulrich Dirnagl, Hans Dieter Volk
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Publication number: 20140051572Abstract: A synergistic pesticidal composition including a Spinosyn and thiamethoxam is used to control cutworms. A seed treatment composition including a Spinosyn and thiamethoxam is used to make coated seeds that exhibit synergy in the control of cutworms. In various aspects, the invention relates to pesticidal compositions, seed treatment compositions, methods of controlling cutworms, methods of treating seeds, and coated seeds produced thereby.Type: ApplicationFiled: August 8, 2013Publication date: February 20, 2014Applicant: DOW AGROSCIENCES LLCInventors: Maria S. Grigera, Maria E. Cometti, Carlos N. Vassallo
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Publication number: 20140031306Abstract: This invention provides a single-dose oral formulation of spinosad for the extended control of a C. felis infestation on a cat at a predictable dose of spinosad that is suitable for administration once every 30 days (i.e., one month). The invention also provides methods of using the formulation of spinosad.Type: ApplicationFiled: July 18, 2013Publication date: January 30, 2014Inventors: Kari Lynette RIGGS, Daniel Earl Snyder, Michelle Leigh TOTTEN
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Publication number: 20140024609Abstract: The present invention relates to methods of treating a bacterial infection in a subject in need thereof comprising administering to the subject an effective amount of the compound of Formula (I) and an anti-inflammatory agent. The present invention provides pharmaceutical compositions comprising an effective amount of the compound of Formula (I) and an anti-inflammatory agent.Type: ApplicationFiled: February 6, 2012Publication date: January 23, 2014Applicant: Optimer Pharmaceuticals ,Inc.Inventors: Yoshi Ichikawa, Sherwood Gorbach
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Publication number: 20130331347Abstract: The present invention relates to methods of treating Clostridium difficile infection in a subject receiving antibiotic therapy for a different infection comprising administering to the subject an effective amount of the compounds described herein.Type: ApplicationFiled: June 28, 2013Publication date: December 12, 2013Applicant: Optimer Pharmaceuticals, Inc.Inventors: Youe-Kong Shue, Sherwood Gorbach, Pamela Sears
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Publication number: 20130324457Abstract: Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R8 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.Type: ApplicationFiled: May 15, 2013Publication date: December 5, 2013Applicants: AVENTIS AGRICULTURE, MERIAL LIMITEDInventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Philip Reid Timmons, William Glenn Cawthorne, Jr., Alberto Perez de Leon
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Patent number: 8598130Abstract: A method of controlling or preventing damage to a plant, which comprises applying on the plant or a surrounding area thereof a combination comprising (I) abamectin, and (II) cyflumetofen, in any desired sequence or simultaneously.Type: GrantFiled: July 21, 2009Date of Patent: December 3, 2013Assignee: Syngenta Crop Protection LLCInventors: Peter Maienfisch, Max Angst, Ottmar Franz Hueter, Jorge Cisneros, Paulo Aramaki, Alfred Rindlisbacher
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Patent number: 8586551Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.Type: GrantFiled: August 31, 2009Date of Patent: November 19, 2013Assignee: Optimer Pharmaceuticals, Inc.Inventors: Youe-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
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Publication number: 20130303472Abstract: The present invention provides solid state forms of Fidaxomycin, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising one or more of the solid state forms of Fidaxomycin, and processes for the preparation of the compositions and formulations. The solid state forms of the present invention exhibit advantageous properties such as improved reliability and reproducibility in manufacturing and processing and stability in formulations.Type: ApplicationFiled: May 17, 2013Publication date: November 14, 2013Inventors: Tamas FONAGY, Adrienne KOVACSNE-MEZEI, Levente SZUROS, Edit Nagyne ARVAI
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Publication number: 20130296167Abstract: Active compound combinations are disclosed which comprise (A) a dithiino-tetracarboximide of formula (I) and a further insecticidally active compound (B). Methods for controlling animal pests such as insects and/or unwanted acarids and for curatively or preventively controlling the phytopathogenic fungi of plants or crops are also disclosed as well as the use of a composition according to the invention for the treatment of seed, to a method for protecting a seed and to the treated seed.Type: ApplicationFiled: April 17, 2013Publication date: November 7, 2013Inventors: Thomas SEITZ, Ulrike Wachendorff-Neumann, Heike Hungenberg, Peter Dahmen
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Publication number: 20130288990Abstract: The invention relates to a method for controlling pests using a combination of insecticides and transgenic plants and consequently improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide.Type: ApplicationFiled: June 28, 2013Publication date: October 31, 2013Inventors: Wolfram Andersch, Christian Funke, Heike Hungenberg, Wolfgang Thielert
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Publication number: 20130276352Abstract: A termite bait includes a plurality of cellulosic food material pieces palatable to termites embedded within a water resistant polyurethane foam matrix. Another termite bait includes a plurality of cellulosic food material pieces embedded within a water-absorbent polyurethane foam matrix. Yet another termite bait includes at least one cellulosic food material piece encapsulated within a water resistant polyurethane foam coating. Such termite baits can be used alone or in a monitoring device or other termite control device. Another termite control device includes a container, a cellulosic food material within the container and a water resistant polyurethane foam positioned to separate the food material from its environment. The container can contain a termite bait as described above or can include a chamber containing a cellulosic food material and at least one pocket containing a polyurethane foam barrier to reduce intrusion of water through the pocket to the food material.Type: ApplicationFiled: March 15, 2013Publication date: October 24, 2013Inventor: Dow AgroSciences LLC
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Publication number: 20130281391Abstract: The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more macrolide compound(s) selected from Group (A) shows an excellent controlling activity on a pest.Type: ApplicationFiled: October 27, 2011Publication date: October 24, 2013Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: So Kiguchi, Soichi Tanaka
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Patent number: 8563053Abstract: A composition and method for treating a bone condition of an animal. The composition includes a nanoformulation of active ingredients. The active ingredients include Lepidium Sativum or other Lepidium extracts, calcium, vitamin D, and antioxidants. The method for treating a bone condition includes introducing the composition into the animal.Type: GrantFiled: October 27, 2010Date of Patent: October 22, 2013Inventors: Shaker A. Mousa, Mohammed H. Qari, Mohammed S. Ardawi
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Publication number: 20130274175Abstract: This invention relates to the treatment or prevention of diseases associated with the use of antibiotics or cancer chemotherapies or antiviral therapies, such as colitis, pseudomembranous colitis, antibiotic associated diarrhea and infections due to C. difficile, C. perfringens, Staphylococcus species including methicillin-resistant Staphylococcus aureus (MRSA) or Enterococcus including vancomycin-resistant enterococci (VRE) with Compound I.Type: ApplicationFiled: April 26, 2012Publication date: October 17, 2013Applicant: OPTIMER PHARMACEUTICALS, INC.Inventors: Youe-Kong Shue, Farah Kondori Babakhani, Franklin W. Okumu, Pamela Suzanne Sears, Starr Louise Miller-Shangle, Robert Brian Walsh
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Publication number: 20130267415Abstract: The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula I wherein one of Y1 and Y2 is S, SO or SO2 and the other is CH2; L is a direct bond or methylene; A1 and A2 are C—H, or one of A1 and A2 is C—H and the other is N; R1 is hydrogen or methyl; R2 is chlorodifluoromethyl or trifluoromethyl; R3 is 3,5-dibromo-phenyl, 3,5-dichloro-phenyl, 3,4-dichloro-phenyl, or 3,4,5-trichloro-phenyl, 3,5-dichloro-4-fluoro-phenyl, or 3,5-bis-trifluoromethylphenyl; R4 is methyl or chlorine; R5 is hydrogen; or R4 and R5 together form a bridging 1,3-butadiene group; and wherein component B is an insecticide. The invention also relates to methods of controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest a combination of components A and B.Type: ApplicationFiled: December 15, 2011Publication date: October 10, 2013Applicant: SYNGENTA PARTICIPATIONS AGInventors: Peter Renold, Jerome Yves Cassayre, Myriem El Qacemi, Jagadish Pabba, Thomas Pitterna
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Publication number: 20130252912Abstract: The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).Type: ApplicationFiled: March 15, 2013Publication date: September 26, 2013Applicant: Optimer Pharmaceuticals, Inc.Inventors: Yoshi Ichikawa, Yu-Hung Chiu, Youe-Kong Shue, Farah Kondori Babakhani
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Publication number: 20130252913Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.Type: ApplicationFiled: March 15, 2013Publication date: September 26, 2013Applicant: Optimer Pharmaceuticals, Inc.Inventors: Youe-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
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Publication number: 20130252914Abstract: The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.Type: ApplicationFiled: March 15, 2013Publication date: September 26, 2013Applicant: Optimer Pharmaceuticals, Inc.Inventors: Yu-Hung Chiu, Tessie Mary Che, Alex Romero, Yoshi Ichikawa, Youe-Kong Shue
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Patent number: 8541022Abstract: A method of treating a superficial or partial thickness burn caused by heat, or by UV or laser radiation is disclosed. The method includes topically applying a topical composition containing an avermectin compound to an affected area immediately after a burn occurs. The method further includes cooling the affected area with ice or water prior to application of the topical composition. Additionally, the method includes topically applying a second topical composition containing fluocinonide and salicylic acid on the affected area to further enhance anti-inflammatory effect of the avermectin compound on the damaged skin.Type: GrantFiled: June 2, 2008Date of Patent: September 24, 2013Assignee: Galderma S.A.Inventors: L. Dean Parks, Jeffrey D. Parks