The Hetero Ring Has Exactly 15 Ring Carbons Patents (Class 514/30)
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Publication number: 20110319263Abstract: The present invention relates to synergistic mixtures of chlormequat chloride with insecticides.Type: ApplicationFiled: February 9, 2010Publication date: December 29, 2011Applicant: BASF SEInventors: Dirk Voeste, Ronald Wilhelm
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Patent number: 8080530Abstract: Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.Type: GrantFiled: May 19, 2009Date of Patent: December 20, 2011Assignee: Galderma S.A.Inventors: Vincent Manetta, Gary R. Watkins
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Publication number: 20110306571Abstract: Use of a macrolide antibiotic for the manufacture of a medicament for the treatment or prevention of a cancer selected from colorectal cancer, Desmoid tumor, bladder cancer, gastric cancer, and breast cancer, the macrolide antibiotic being one or more of: tylosin, pharmaceutically acceptable salts thereof, and derivatives thereof; erythromycin, pharmaceutically acceptable salts thereof, and derivatives thereof; oleandomycin, pharmaceutically acceptable salts thereof, and derivatives thereof; and spiramycin, pharmaceutically acceptable salts thereof, and derivatives thereof. Also provided are pharmaceutical compositions and methods for the treatment or prevention of the above mentioned cancers and methods for treating or preventing, in a mammal, a cancer that expresses a mutated APC gene.Type: ApplicationFiled: June 12, 2007Publication date: December 15, 2011Applicant: Ramot at Tel Aviv University Ltd.Inventor: Rina Rosin-Arbesfeld
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Publication number: 20110294751Abstract: Veterinary compositions which provide a high-dose of doramectin or a high-dose veterinary combination composition which comprises doramectin and one or more other antiparasitic agents is disclosed. The compositions provide both antiparasitic efficacy and a significantly reduced withhold time.Type: ApplicationFiled: February 2, 2010Publication date: December 1, 2011Applicant: PFIZER INC.Inventors: Alvimar Jose da Costa, Stephen Lee Secreast, Rodrigo Valarelli
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Publication number: 20110293533Abstract: Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof and a component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing.Type: ApplicationFiled: August 11, 2011Publication date: December 1, 2011Applicant: E.I. DU PONT NEMOURS AND COMPANYInventors: Isaac Billy Annan, John Lindsey Flexner, Hector Eduardo Portillo, George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Patent number: 8067382Abstract: The invention relates to a novel formulation having the advantage of including triclabendazole in solution. In addition a further anthelmintic may be included. The formulation is made by mixing the abamectin and benzyl alcohol and mixing this with triclabendazole and butyl dioxitol. The mix is then heated to dissolve the active, and allowed to cool at which stage the solution is diluted to volume with PEG 4000. The present invention overcomes the solubility difficulties of triclabendazole and presents the triclabendazole in a solution.Type: GrantFiled: December 7, 2009Date of Patent: November 29, 2011Assignee: Merial LimitedInventor: Colin Manson Harvey
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Publication number: 20110281725Abstract: Novel, environmentally safe compositions for the control of pests and methods of using these compositions are disclosed. The compositions may comprise one or more high terpene (50% by weight or more) based oils, such as but not limited to citrus oil, surfactants and other ingredients disclosed herein. Preferably, the one or more high terpene (50% by weight or more) based oils, such as but not limited to citrus oil, is cold pressed orange oil.Type: ApplicationFiled: February 6, 2008Publication date: November 17, 2011Inventor: Erroll M. Pullen
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Publication number: 20110275583Abstract: Novel active compound combinations comprising compounds of the formula (I) and compounds of the formula (II) have very good insecticidal and acaricidal properties.Type: ApplicationFiled: April 28, 2011Publication date: November 10, 2011Applicant: Bayer CropScience AGInventors: Thomas BRETSCHNEIDER, Heike HUNGENBERG, Martin Füsslein
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Publication number: 20110274631Abstract: Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and metronidazole or salt, ester or derivative thereof, are useful for treating afflictions of the skin, especially rosacea.Type: ApplicationFiled: March 3, 2011Publication date: November 10, 2011Applicant: GALDERMA S.A.Inventors: Alexandre KAOUKHOV, Colette Pernin
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Patent number: 8053418Abstract: A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae, and an anti-penicillin resistant pneumococci agent that includes the compound as an active ingredient are provided. Thus, an anti-penicillin resistant pneumococci agent is provided that includes as an active ingredient a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof, or hydrates thereof: wherein, in the formula (I), R represents any one of a halogen atom, an azido group, Ra-Wa-, Rb-Wb-, Rc-Wc-, and RdRd?N—.Type: GrantFiled: January 24, 2006Date of Patent: November 8, 2011Assignee: Microbial Chemistry Research FoundationInventors: Toshiaki Miyake, Yoshiaki Takahashi
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Patent number: 8048861Abstract: The present invention relates to an active composition for controlling or eradicating Phthiraptera, Siphonaptera and Acarina Pests, typically in domestic animals, comprising a synergistic combination of at least one A83543 compound and at least one macrocyclic lactone. The invention also relates to the use of the active composition in pesticidal formulations, the formulations themselves and to the various applications of those formulations as pesticides, specifically in controlling all species of Phthiraptera, Siphonaptera and Acarina pests, typically in domestic animals. Such applications include the control of such external Phthiraptera, Siphonaptera and Acarina pests in domestic animals including but not limited to sheep, cattle, poultry, pigs, goats, camelids, horses, dogs and cats.Type: GrantFiled: April 9, 2010Date of Patent: November 1, 2011Assignee: Eli Lilly and CompanyInventors: Lionel Barry Lowe, James Terence Rothwell
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Publication number: 20110263520Abstract: Disclosed is a composition for use in controlling harmful organisms, comprising as active ingredients at least one of 16-keto aspergillimide, its enantiomers, their mixture, or their acid addition salts and at least one of other harmful organism control agents. The present invention provides a composition for use in controlling harmful organisms that has excellent insecticidal activity or penetrative transferable insecticidal activity against a wide range of harmful organisms, particularly agricultural and horticultural insect pests.Type: ApplicationFiled: December 21, 2009Publication date: October 27, 2011Inventors: Ryo Horikoshi, Masahiro Nomura, Satoshi Nakamura, Mizuki Hayashimoto, Mariko Tsuchida, Kazuhiko Oyama, Masaaki Mitomi
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Publication number: 20110245191Abstract: This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.Type: ApplicationFiled: April 1, 2011Publication date: October 6, 2011Inventors: Joseph K Rosentel, JR., Monica Tejwani, Arima Das-Nandy
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Publication number: 20110230429Abstract: What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH?CH— or —CH2—CH2—; R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl; R2 is for example C1-C12-alkyl, C2-C12-alkenyl or C2-C12-alkinyl; which are optionally substituted with one to five substituents selected from the group consisting of OH, halogen, CN, —N3, —NO2, C3-C8-Cycloalkyl, norbornylenyl-, C3-C8-Cycloalkenyl; C3-C8-halocycloalkyl, C1-C12-alkoxy, C1-C6-alkoxy-C1-C6-alkoxy, C3-C8-cycloalkoxy, C1-C12-haloalkoxy, C1-C12-alkylthio, C3-C8-cycloalkylthio, C1-C12-haloalkylthio, C1-C12-alkylsulfinyl, C3-C8-cycloalkylsulfinyl, C1-C12-haloalkylsulfinyl, C3-C8-halocycloalkylsulfinyl, C1-C12-alkylsulfonyl, C3-C8-cycloalkylsulfonyl, C1-C12-haloalkylsulfonyl, C3-C8-halocycloalkylsulfonyl, —NR4R6, —X—C(?Y)—R4, —X—C(?Y)—Z—R4, —P(?O)(OC1-C6-alkyl)2, aryl, heterocyclyl, aryloxy, arylthio and heterocyclyloxy; R3 is for example H, C1-C12-alkyl or C1-C12-alkyl which is optionally substituted and, where applicable, to E/Z isomers, mixtuType: ApplicationFiled: May 27, 2011Publication date: September 22, 2011Applicant: SYNGENTA CROP PROTECTION, LLCInventors: Peter Maienfisch, Fiona Murphy Kessabi, Jérôme Cassayre, Laura Quaranta, Thomas Pitterna, Ottmar Franz Hueter, Pierre Jung
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Publication number: 20110223234Abstract: A palatable, edible soft chewable medication vehicle for delivery of a pharmaceutically acceptable active ingredient, such as a drug, to an animal or human subject. The edible soft chews contain only food grade or better inactive ingredients, and preferably do not contain ingredients of animal origin. Processes for manufacturing the edible soft chews do not require the use of heat or the addition of water during mixing of active and inactive ingredients, provide stable concentrations of the active ingredient, and produce chews of consistent weight and texture.Type: ApplicationFiled: May 25, 2011Publication date: September 15, 2011Inventors: Neil E. Paulsen, Roland Johnson, Michael Coffee
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Patent number: 8017589Abstract: What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH?CH— or —CH2—CH2—; R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl; R2 is for example C1-C12-alkyl, C2-C12-alkenyl or C2-C12-alkinyl; which are optionally substituted with one to five substituents selected from the group consisting of OH, halogen, CN, —N3, —NO2, C3-C8-Cycloalkyl, norbornylenyl-, C3-C8-Cycloalkenyl; C3-C8-halocycloalkyl, C1-C12-alkoxy, C1-C6-alkoxy-C1-C6-alkoxy, C3-C8-cycloalkoxy, C1-C12-haloalkoxy, C1-C12-alkylthio, C3-C8-cycloalkylthio, C1-C12-haloalkylthio, C1-C12-alkylsulfinyl, C3-C8-cycloalkylsulfinyl, C1-C12-haloalkylsulfinyl, C3-C8-halocycloalkylsulfinyl, C1-C12-alkylsulfonyl, C3-C8-cycloalkylsulfonyl, C1-C12-haloalkylsulfonyl, C3-C8-halocycloalkylsulfonyl, —NR4R6, —X—C(?Y)—R4, —X—C(?Y)—Z—R4, —P(?O)(OC1-C6-alkyl)2, aryl, heterocyclyl, aryloxy, arylthio and heterocyclyloxy; R3 is for example H, C1-C12-alkyl or C1-C12-alkyl which is optionally substituted and, where applicable, to E/Z isomers, mixtuType: GrantFiled: April 27, 2010Date of Patent: September 13, 2011Assignee: Syngenta Crop Protection LLCInventors: Peter Maienfisch, Fiona Murphy Kessabi, Jerome Cassayre, Laura Quaranta, Thomas Pitterna, Ottmar Franz Hueter, Pierre Jung
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Publication number: 20110200684Abstract: Synergistic pesticidal mixtures are provided.Type: ApplicationFiled: April 28, 2011Publication date: August 18, 2011Applicant: DOW AGROSCIENCES LLCInventors: Jim X. Huang, Jonathan M. Babcock, Thomas Meade, Marc Farrow
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Publication number: 20110201567Abstract: A method for reducing alcohol consumption in a subject includes a step of identifying a subject exhibiting at least one symptom of alcoholism and then administering a therapeutically effective amount of an Ivermectin analogue-containing composition to the subject. A method of screening Ivermectin analogues for reducing alcohol consumption is also provided.Type: ApplicationFiled: January 21, 2011Publication date: August 18, 2011Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Daryl L. Davies, Ronald L. Alkana, Liana Asatryan, Daya I. Perkins, Maya S. Popova
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Publication number: 20110201545Abstract: A method of making a gel-type livestock feed includes initially forming a feed mixture by mixing feed nutrient components, water, alginate, and a calcium component insoluble in water or a sequestrate to inhibit the calcium component from reacting with the alginate. Once the feed mixture is formed, the calcium component is solubilized or the sequestrates affecting the reactivity between the alginate and the calcium component is removed such that a gel feed is formed that includes a gel matrix containing the feed nutrient components. The gel feed may then be fed to the livestock. In another aspect of the present invention, piglets are weaned by feeding the gel feed for at least seven days directly after weaning. The gel feed may also include protein derived from blood with or without egg protein.Type: ApplicationFiled: April 28, 2011Publication date: August 18, 2011Inventors: Kent Lanter, Brenda de Rodas, Bill L. Miller, Gary E. Fitzner
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Publication number: 20110190231Abstract: The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia): wherein, R3, R4, R5, R6, R7, P, Q, T, V, W, X, Y, Z, a, m and n are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.Type: ApplicationFiled: April 13, 2011Publication date: August 4, 2011Inventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Philip Reid Timmons
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Publication number: 20110165100Abstract: Pharmaceutical/dermatological compositions useful for the prevention/treatment of disorders of the skin, especially rosacea, contain thus effective amounts of at least one avermectin compound, e.g., ivermectin, and at least one azelaic acid compound or salt or derivative thereof, formulated into a physiologically acceptable medium therefor.Type: ApplicationFiled: July 6, 2010Publication date: July 7, 2011Applicant: Galderma S.A.Inventors: Alexandre KAOUKHOV, Colette PERNIN
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Publication number: 20110144045Abstract: A method for increasing the bioavailability of antiparasitic active ingredients, and therefore to potentiate the effects thereof, including combining antiparasitic active ingredients with an adjuvant, wherein, the antiparasitic active ingredients are capable of being recognized and binding to cellular transporters in order to be transported out of cells without being able to reach an intracellular therapeutic target, the transporters being present in the cells of the human or animal organism to which the antiparasitic active ingredients are administered, and, optionally, in the cells of parasites against which the antiparasitic active ingredients are administered, the adjuvant is a compound corresponding to fumagillin of the following formula (II):Type: ApplicationFiled: December 22, 2010Publication date: June 16, 2011Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Michel ALVINERIE, Jacques DUPUY, Anne LESPINE, Jean Francois SUTRA
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Publication number: 20110144046Abstract: An anthelmintic composition comprising two or more active agents, each agent being selected from a separate anthelmintically active family, the families being a macrocyclic lactone (ML), levamisole or its equivalent and a benzimidazole, in a suitable carrier, which includes at least one effective protective agent, which stabilises the chemical and physical activity of the ML, such as hydroxypropyl starch phosphate.Type: ApplicationFiled: August 18, 2009Publication date: June 16, 2011Inventor: Charles Robert Hillier
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Patent number: 7939565Abstract: The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the formula (I) and the active compounds identified in the disclosure.Type: GrantFiled: September 14, 2007Date of Patent: May 10, 2011Assignee: Bayer CropScience AGInventors: Jorg Konze, Wolfram Andersch, Dietrich Stubler, Rudiger Fischer
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Patent number: 7906127Abstract: An insecticidal mixture of gamma-cyhalothrin [(S)-?-cyano-3-phenoxybenzyl (Z)-(1R,3R)-3-(2-chloro-3,3,3-tzifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate] and one or more further active ingredients; compositions containing them and their use.Type: GrantFiled: July 10, 2002Date of Patent: March 15, 2011Assignee: Syngenta LimitedInventor: Martin Stephen Clough
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Publication number: 20110052515Abstract: Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and benzoyl peroxide, are useful for treating afflictions of the skin, especially rosacea.Type: ApplicationFiled: November 3, 2010Publication date: March 3, 2011Applicant: Galderma S.A.Inventors: Alexandre KAOUKHOV, Colette PERNIN
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Publication number: 20110009350Abstract: Oil-in-water emulsion formulations (EW) of avermectins based on esters of fatty acids as solvent and the use of such formulations for the control of crop pests.Type: ApplicationFiled: November 17, 2006Publication date: January 13, 2011Inventors: Morten Pedersen, Henriette Woldum
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Publication number: 20110003763Abstract: Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and benzoyl peroxide, are useful for treating afflictions of the skin, especially rosacea.Type: ApplicationFiled: July 6, 2010Publication date: January 6, 2011Applicant: Galderma S.A.Inventors: Alexandre KAOUKHOV, Colette Pernin
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Publication number: 20100311677Abstract: The novel active compound combinations comprising compounds of the formulae (I) and (II) have very good insecticidal and acaricidal properties.Type: ApplicationFiled: September 9, 2008Publication date: December 9, 2010Applicant: Bayer CropScience AGInventors: Reiner Fischer, Wolfram Andersch, Heike Hungenberg
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Publication number: 20100298137Abstract: The present invention relates to novel active compound combinations comprising at least one known compound of the formula (I) in which R is as defined in the description, and at least one further known active compound from the classes of the benzenedicarboxamides, the macrolides, the diacylhydrazines, the carboxylates or another class. Combinations of the present invention are highly suitable for controlling animal pests such as insects and unwanted acarids.Type: ApplicationFiled: March 19, 2007Publication date: November 25, 2010Applicant: BAYER CROPSCIENCE AGInventors: Heike Hungenberg, Peter Jeschke, Rüdiger Fischer, Robert Velten, Thomas Schenke, Wolfram Andersch, Wolfgang Thielert
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Publication number: 20100285012Abstract: The subject application provides small compounds that are able to suppress autophagy in various cells. These compounds are useful in augmenting the existing treatments of various cancers and microbial/parasitic infections. Thus, the subject application also provides methods of treating various types of cancers and microbial/parasitic infections. Also provided by the subject application are methods of suppressing the expansion of autophagosomes within cells or individuals and inhibiting the lipidation of autophagy-related protein 8 (Atg8).Type: ApplicationFiled: January 5, 2009Publication date: November 11, 2010Applicant: University of FLorida Research Foundation Inc.Inventors: William A. Dunn, JR., Debra E. Akin, Ann Progulske-Fox, David A. Ostrov
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Patent number: 7807151Abstract: The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the utilization of one or more species or strains of lactic acid-producing bacteria, preferably strains of Bacillus coagulans, for the control of gastrointestinal tract pathogens, including antibiotic-resistant gastrointestinal tract pathogens, and their associated diseases by both a reduction in the rate of colonization and the severity of the deleterious physiological effects of the colonization of the antibiotic-resistant pathogen. In addition, the present invention relates to the utilization of therapeutic compounds comprised of lactic acid-producing bacteria and anti-microbial agents such as antibiotics, anti-fungal compounds, anti-yeast compounds, or anti-viral compounds.Type: GrantFiled: April 23, 2008Date of Patent: October 5, 2010Assignee: Ganeden Biotech, IncorporatedInventor: Sean Farmer
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Publication number: 20100249050Abstract: An epothilone glycoside having a formula of and a pharmaceutical composition having the epothilone glycoside and a pharmaceutically acceptable excipient. The epothilone glycoside or the pharmaceutical composition having the epothilone glycoside can prevent or treat cancers such as liver cancer, lung cancer, and breast cancer.Type: ApplicationFiled: June 9, 2010Publication date: September 30, 2010Applicant: SHANDONG UNIVERSITYInventors: Yuezhong LI, Yuemao SHEN, Lin ZHAO, Chunhua LU
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Publication number: 20100234312Abstract: Novel avermectin derivatives of the formula (I) in which —C22R1-A-C23R2, R3, R4 and R5 have the meanings given in the description, processes for preparing these compounds and their use for controlling animal pests, and also novel intermediates and their preparationType: ApplicationFiled: August 8, 2007Publication date: September 16, 2010Applicant: BAYER CROPSCIENCE AGInventors: Peter Jeschke, Gunter Karig, Robert Velten, Reiner Fischer, Olga Malsam, Ulrich Görgens, Christian Arnold, Erich Sanwald, Achim Harder, Andreas Turberg
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Patent number: 7781411Abstract: Certain derivatives of avermectin, avermectin monosaccharide and avermectin aglycone, having on the 4?, 4? or 13 position, respectively, a 6-membered cyclic acetal with a substituent on position 2, that are useful in controlling pests, in particular pests that are harmful to crop plants and to its propagation material, such as representatives of the class insecta, the order acarina and the class nematode, are provided.Type: GrantFiled: August 19, 2005Date of Patent: August 24, 2010Assignee: Syngenta Crop Protection, Inc.Inventors: Ottmar Franz Hueter, Thomas Pitterna, Pierre Jung, Fiona Murphy Kessabi, Laura Quaranta
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Publication number: 20100210574Abstract: What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH?CH— or —CH2—CH2—; R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl; R2 is for example C1-C12-alkyl, C2-C12-alkenyl or C2-C12-alkinyl; which are optionally substituted with one to five substituents selected from the group consisting of OH, halogen, CN, —N3, —NO2, C3-C8-Cycloalkyl, norbornylenyl-, C3-C8-Cycloalkenyl; C3-C8-halocycloalkyl, C1-C12-alkoxy, C1-C6-alkoxy-C1-C6-alkoxy, C3-C8-cycloalkoxy, C1-C12-haloalkoxy, C1-C12-alkylthio, C3-C8-cycloalkylthio, C1-C12-haloalkylthio, C1-C12-alkylsulfinyl, C3-C8-cycloalkylsulfinyl, C1-C12-haloalkylsulfinyl, C3-C8-halocycloalkylsulfinyl, C1-C12-alkylsulfonyl, C3-C8-cycloalkylsulfonyl, C1-C12-haloalkylsulfonyl, C3-C8-halocycloalkylsulfonyl, —NR4R6, —X—C(?Y)—R4, —X—C(?Y)—Z—R4, —P(?O)(OC1-C6-alkyl)2, aryl, heterocyclyl, aryloxy, arylthio and heterocyclyloxy; R3 is for example H, C1-C12-alkyl or C1-C12-alkyl which is optionally substituted and, where applicable, to E/Z isomers, mixType: ApplicationFiled: April 27, 2010Publication date: August 19, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Peter Maienfisch, Fiona Murphy Kessabi, Jerome Cassayre, Laura Quaranta, Thomas Pitterna, Ottmar Franz Hueter, Pierre Jung
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Publication number: 20100204167Abstract: The novel active compound combinations comprising a compound of the formula (I-1) or (I-2) and the active compounds (1) to (26) listed in the description have very good insecticidal and acaricidal properties.Type: ApplicationFiled: July 6, 2007Publication date: August 12, 2010Inventors: Reiner Fischer, Wolfram Andersch, Thomas König, Anton Kraus, Emmanuel Salmon, Heike Hungenberg
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Patent number: 7772194Abstract: The present invention relates to an active composition for controlling or eradicating Phthiraptera, Siphonaptera and Acarina Pests, typically in domestic animals, comprising a synergistic combination of at least one A83543 compound and at least one macrocyclic lactone. The invention also relates to the use of the active composition in pesticidal formulations, the formulations themselves and to the various applications of those formulations as pesticides, specifically in controlling all species of Phthiraptera, Siphonaptera and Acarina pests, typically in domestic animals. Such applications include the control of such external Phthiraptera, Siphonaptera and Acarina pests in domestic animals including but not limited to sheep, cattle, poultry, pigs, goats, camelids, horses, dogs and cats.Type: GrantFiled: September 17, 2001Date of Patent: August 10, 2010Assignee: Eli Lilly and CompanyInventors: Lionel Barry Lowe, James Terence Rothwell
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Publication number: 20100197624Abstract: A method is provided for the treatment of parasitic infestations in mammals, comprising the step of simultaneously or sequentially administering to the mammal effective amounts of (a) 2-desoxoparaherquamide; and (b) abamectin. Also provided is an anthelmintic composition comprising 2-desoxoparaherquamide and abamectin.Type: ApplicationFiled: June 16, 2008Publication date: August 5, 2010Applicants: PFIZER INC., PFIZER PRODUCTS INC.Inventors: Timothy G. Geary, Peter Rolfe
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Patent number: 7754696Abstract: A stable, palatable solution of Ivermectin in water is provided for the mass medication of animals. The present formulation does not require the use of benzyl alcohol and is stable indefinitely in the concentrated form and for up to 30 days when mixed with water.Type: GrantFiled: December 6, 2007Date of Patent: July 13, 2010Assignee: Pharmaceutical Solutions, Inc.Inventor: Michael Strobel
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Publication number: 20100173858Abstract: Compositions comprising at least one bactericidal antibiotic from the group of macrolides and a non-steroid anti-inflammatory with selective inhibiting activity for cycloxygenase 2 (COX-2). The present invention also refers to a dosage form of said compositions, as well as a method to treat pet animals, particularly dogs and cats. Compositions of the present invention are particularly useful for administration to provide animals with dosages of about 1.0 to 50 mg of compound A/kg of body weight of the animal and about 0.05 to 5.0 mg of compound B/kg of body weight of the animal, being compound A preferably azithromycin and compound B, meloxicam.Type: ApplicationFiled: March 24, 2008Publication date: July 8, 2010Inventor: Dolivar Coraucci Neto
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Publication number: 20100168043Abstract: The present invention provides a method for the prevention/treatment of hark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone.Type: ApplicationFiled: March 21, 2006Publication date: July 1, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Donald M. Grossman, David Cox
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Patent number: 7737261Abstract: Avermectin B1 and avermectin B1 monosaccharide derivative compounds having an alkoxymethyl substituent in the 4?- or 4?-position; a process for preparing and using these compounds and their tautomers; pesticides whose active compound is selected from these compounds and their tautomers; and a process for preparing these compounds and compositions are provided.Type: GrantFiled: December 19, 2003Date of Patent: June 15, 2010Assignee: Syngenta Corp Protection, Inc.Inventors: Peter Maienfisch, Fiona Murphy Kessabi, Jérôme Cassayre, Laura Quaranta, Thomas Pitterna, Ottmar Franz Hueter, Pierre Jung
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Patent number: 7732416Abstract: What is described are a compound of the formula in which R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 is H, unsubstituted or mono- to pentasubstituted C1-C12alkyl or unsubstituted or mono- to pentasubstituted C1-C12alkenyl; R3 is C2-C12alkyl, mono- to pentasubstituted C1-C12alkyl, unsubstituted or mono- to pentasubstituted C1-C6alkoxy-C1-C6alkyl, unsubstituted or mono- to pentasubstituted C3-C12cycloalkyl, C2-C12alkenyl, C2-C12alkynyl; or R2 and R3 together are an alkylene or alkenylene bridge; with the proviso that R1 is not sec-butyl or isopropyl if R2 is H and R3 is 2-hydroxyethyl, isopropyl, n-octyl or benzyl; or, if appropriate, in E/Z isomer, an E/Z isomer mixture and/or a tautomer thereof; a process for preparing and using these compounds and their tautomers; pesticides whose active compound is selected from these compounds and their tautomers; and a process for preparing these compounds and compositions, and the use of these compounds and compositions.Type: GrantFiled: December 28, 2005Date of Patent: June 8, 2010Assignee: Merial LimitedInventors: Thomas Pitterna, Anthony Cornelius O'Sullivan, William Lutz
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Publication number: 20100130437Abstract: A topical pharmaceutical composition comprising an antibiotic is useful for the prevention of Lyme disease.Type: ApplicationFiled: July 24, 2008Publication date: May 27, 2010Inventors: Gustave Huber, Uta Hüttenes, Caroline Roosens-von Bidder
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Publication number: 20100120652Abstract: Methods for preventing or eradicating an infestation of bed mites or bed bugs in an article by contacting the article with an effective amount of an avermectin-containing composition. Avermectin-containing compositions used in the disclosed method are also described.Type: ApplicationFiled: August 10, 2009Publication date: May 13, 2010Inventor: Michael L. Corrado
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Patent number: 7704961Abstract: Described is a compound of the formula (I) wherein the bond between carbon atoms 22 and 23 is a single or double bond; m is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and either (A) R2 is —N(R3)R4, and (1) X is 0, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, mono- to pentasubstituted C1-C12alkyl, unsubstituted or mono- to pentasubstituted C3-C12cycloalkyl; or (2) X is S, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl; or (3) X is 0 or S, wherein R3 and R4 together are, for instance, a three- to seven membered alkylene or a four- to seven-membered alkenylene bridge; or (B) R2 is OR5, X is 0 or S, wherein R5 is, for instance, C1-C12alkyl, mono- to pentasubstituted C1-C12alkyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof, in each case in free form orType: GrantFiled: August 27, 2004Date of Patent: April 27, 2010Assignee: Merial LimitedInventors: Fiona Murphy Kessabi, Thomas Pitterna, Peter Maienfisch, Jérôme Cassayre, Laura Quaranta, Pierre Jung, Ottmar Franz Hueter
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Patent number: 7687471Abstract: The present invention provides a stable veterinary oral composition which comprises one or more surfactants, a water-miscible solvent, optionally an oil and an effective amount of each of a benzimidazole antihelmintic compound, such as triclabendazole and a macrocyclic lactone, such as moxidectin. Said composition is useful for treating and controlling endo- and ectoparasitic infection and infestation in a homeothermic animal.Type: GrantFiled: December 5, 2006Date of Patent: March 30, 2010Assignee: Wyeth LLCInventors: Jon C. Hayes, Debora L. Guido, Jacob A. Zupan
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Patent number: 7687470Abstract: Avermectin and avermectin monosaccharaide compounds, derivatives, and compositions thereof are provided as well as processes for preparing such compounds, derivatives, and compositions. Intermediates in the preparation of avermectin and avermectin monosaccharaide derivatives and methods of controlling pests are also provided. The avermectin and avermectin monosaccharaide derivatives are demonstrated as useful in controlling pests, in particular pests that are harmful to crop plants and to its propagation materials, such as representatives of the class insecta, the order Acarina and the class nematede.Type: GrantFiled: March 9, 2005Date of Patent: March 30, 2010Assignee: Syngenta Crop Protection, Inc.Inventors: Pierre Jung, Thomas Pitterna, Fiona Murphy Kessabi, Laura Quaranta, Ottmar Franz Hueter
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Patent number: 7678773Abstract: A compound of formula wherein X? is an anion; n is 1, 2, 3 or 4; R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl; R2 is hydrogen, unsubstituted or substituted C1-C12alkyl or C2-C12alkenyl; R3 is hydrogen, unsubstituted or substituted C1-C12alkyl, C3-C12cycloalkyl, C2-C12alkenyl; or C2-C12alkynyl; or R2 and R3 together are an alkylene or alkenylene bridge; and, where applicable, E/Z isomers, E/Z isomeric mixtures and/or tautomers; with the proviso that R1 is not sec-butyl or isopropyl when R2 is H and R3 is methyl; and, where applicable, their possible tautomers; a process for the preparation of those compounds and their tautomers and the use thereof; pesticidal compositions in which the active ingredient has been selected from those compounds and their tautomers; and a process for the preparation of those compositions and the use thereof; intermediates, in free form or in salt form, for the preparation of those compounds and, where applicable, their tautomers, in free form or in salt form, are descrType: GrantFiled: December 28, 2005Date of Patent: March 16, 2010Assignee: Merial LimitedInventor: Thomas Pitterna