The Hetero Ring Has Exactly 15 Ring Carbons Patents (Class 514/30)
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Patent number: 7674475Abstract: A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treating and controlling endoparasiticidal infection and infestation in a homeothermic animal.Type: GrantFiled: December 24, 2004Date of Patent: March 9, 2010Assignee: Wyeth LLCInventors: Shobhan S. Sabnis, Jon Hayes, Jack A. Zupan
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Patent number: 7671034Abstract: The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is used in the treatment of parasites in mammals, in particular swine and horses. The invention further relates to a method to extend the shelf life of a stable premix feed or feed-like formulation for the treatment of parasite infestation in swine and horses comprising controlling the amount of an already existing antioxidant or stabilizer in the formulation to decrease or to prevent the formation of acid/base catalyzed decomposition of the active ingredient.Type: GrantFiled: March 1, 2004Date of Patent: March 2, 2010Assignee: Merial LimitedInventor: Keith Allan Freehauf
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Publication number: 20100016248Abstract: The invention relates to a tablet formulated for administration to an animal to treat parasite infestation. The tablet includes at least one macrocyclic lactone compound with anthelmintic activity dissolved in at least one organic solvent and subsequently formulated into a tablet. The tablets produced have a high degree of stability when stored over time and also provide the animal with a dose of agent sufficient to be therapeutically effective.Type: ApplicationFiled: December 18, 2007Publication date: January 21, 2010Applicant: BOMAC RESEARCH LIMITEDInventors: Karthigeyan Nanjan, Fadil Al Alawi, Wayne Frederick Leech, Man Yik Li, Steve Li
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Patent number: 7648711Abstract: A sustained release formulation by using dimeticone as the dispersion medium, which includes active ingredient (e.g., drugs against parasites, insecticides, NSAIDs, antibiotics, sex hormone like agents or oily soluble vitamins) and dimeticone as the medium. Suitable stabilizer, antioxidant, local analgesics and material for sustained release may be added. The formulation is bio-compatible, stable and injectable.Type: GrantFiled: October 8, 2003Date of Patent: January 19, 2010Inventors: Yuwan Wang, Zhende Pan, Xiaoxi Dai
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Patent number: 7645816Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y??(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ?-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: GrantFiled: August 27, 2003Date of Patent: January 12, 2010Assignee: National Research Council of CanadaInventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Patent number: 7638545Abstract: A formulation having triclabendazole in solution. In addition a further anthelmintic may be included. The formulation is made by mixing the abamectin and benzyl alcohol and mixing this with triclabendazole and butyl dioxitol. The mix is then heated to dissolve the active, and allowed to cool at which stage the solution is diluted to volume with PEG 4000.Type: GrantFiled: April 14, 2000Date of Patent: December 29, 2009Assignee: Merial LimitedInventor: Colin Manson Harvey
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Publication number: 20090318375Abstract: This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.Type: ApplicationFiled: June 6, 2003Publication date: December 24, 2009Applicant: Hanmi Pharm Co., LtdInventors: Bo Sung Kwon, Eun Sook Kim, Hee Cheol Kim, Sangmin Yun, Myoung-sil Ko, Tae Hun Song, Han Kyong Kim, Kwee Hyun Suh, Gwansun Lee
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Patent number: 7632820Abstract: Disclosed are compounds of the formulain which n is 0 or 1; X—Y is —CH?CH— or —CH2—CH2—; Z is —C(?O)—, —C(?S)— or —SO2—; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and R2 is R3-Z-, R3—O-Z-, R4 or -Z-N(R6)(R7); Q is O or —N—R5; R3 and R4 are for example H, C1C12alkyl, C2-C12alkenyl, C2-C12alkynyl, C3-C12zcycloalkyl, C5-C12cycloalkenyl, aryl or heterocyclyl; R5 is for example H, C1-C8alkyl, hydroxy-C1-C8alkyl, C3-C8cycloalkyl, C2-C8alkenyl, C2-C8alkynyl, phenyl or benzyl; R6 and R7 are for example, H, unsubstituted or mono- to pentasubstituted C1-C12alkyl, unsubstituted or mono- to pentasubstituted C2-C12alkenyl or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof, in each case in free form or in salt form, are useful as pesticides.Type: GrantFiled: January 30, 2004Date of Patent: December 15, 2009Assignee: Merial LimitedInventors: Thomas Pitterna, Peter Maienfisch, Fiona Murphy Kessabi, Jerome Cassayre, Laura Quaranta, Pierre Jung
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Patent number: 7605134Abstract: A description is given of compounds of the formula which in the 4?-position has the (S)-configuration and wherein R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl; R2 is hydrogen, optionally substituted C1-C12alkyl or optionally substituted C2-C12alkenyl; R3 is C1-C12alkyl, optionally substituted C1-C12alkyl, optionally substituted C1-C12alkoxy-C1-C12alkyl, optionally substituted C3-C12cycloalkyl, optionally substituted C2-C12alkenyl; optionally substituted C4-C12cycloalkenyl, optionally substituted C2-C12alkynyl; or R2 and R3 together are a three- to seven-membered alkylene or four- to seven-membered alkenylene bridge in each of which a CH2 group may have been replaced by O, S or NR4; X is O or S; R4 is C1-C8alkyl, C3-C8cycloalkyl, C2-C8alkenyl, C2-C8alkynyl, benzyl or C(?O)—R5; R5 is for example H, OH, SH, C1-C12alkyl, C2-C8alkenyl, C2-C8alkynylyl or C1-C12haloalkyl; and, where appropriate, E/Z isomers, mixtures of E/Z isomers and/or tautomers thereof, in each case in free form or in salt form; to a proType: GrantFiled: August 20, 2002Date of Patent: October 20, 2009Assignee: Merial LimitedInventor: Hans Tobler
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Publication number: 20090258065Abstract: Compositions and nanoemulsions containing lipid nanocapsules dispersed in a hydrophilic phase, such nanocapsules including at least one avermectin compound, are useful for the treatment of dermatological pathologies, e.g., rosacea.Type: ApplicationFiled: April 10, 2009Publication date: October 15, 2009Applicant: GALDERMA S.A.Inventors: Lara Baudonnet, Claire Mallard
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Publication number: 20090233877Abstract: Compounds of the natural avermectin family are formulated into pharmaceutical compositions useful for the treatment of dermatological conditions in humans, in particular rosacea.Type: ApplicationFiled: March 20, 2009Publication date: September 17, 2009Applicant: GALDERMA S.A.Inventors: Alexandre KAOUKHOV, Cecile Cousin
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Patent number: 7585887Abstract: The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula ?in which the groups W, X, Y, Z, A, B, D, and G have the meanings given in the disclosure, and (b) the active compounds (1) to (29) listed in the disclosure.Type: GrantFiled: October 29, 2001Date of Patent: September 8, 2009Assignee: Bayer CropScience AGInventors: Reiner Fischer, Christoph Erdelen
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Patent number: 7582612Abstract: The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus tetrahydropyrimidines. An examples of a tetrahydropyrimidine includes pyrantel. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.Type: GrantFiled: August 3, 2004Date of Patent: September 1, 2009Assignees: Hartz Mountain Corporation, Virbac CorporationInventors: Albert Ahn, Ian Cottrell
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Patent number: 7563773Abstract: This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agents contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent.Type: GrantFiled: April 15, 2005Date of Patent: July 21, 2009Assignee: Merial LimitedInventors: Keith Freehauf, Maryam Moaddeb
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Patent number: 7550440Abstract: Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.Type: GrantFiled: October 24, 2005Date of Patent: June 23, 2009Assignee: Galderma S.A.Inventors: Vincent Manetta, Gary R. Watkins
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Patent number: 7521429Abstract: A compound of formula (I) wherein the bond between carbon atoms 22 and 23 may be a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl, or C2-C12alkenyl; R2 and R3 are, for example, independently of each other hydrogen, C1-C12alkyl, C3-C12cycloalkyl, C2-C12alkenyl, C2-C12alkynyl, aryl or heteroaryl; and, where applicable, to E/Z isomers, mixtures of E/Z isomers, diastereomers and/or tautomers, in each case in free form or in salt form; pesticidal compositions in which the active ingredient has been selected from those compounds and their tautomers; and a method of controlling pests using those compositions are described.Type: GrantFiled: June 15, 2004Date of Patent: April 21, 2009Assignee: Merial LimitedInventors: Thomas Pitterna, Pierre Jung, Fiona Murphy Kessabi, Jerome Cassayre, Laura Quaranta, Ottmar Franz Hueter
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Publication number: 20090093421Abstract: Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.Type: ApplicationFiled: March 31, 2008Publication date: April 9, 2009Applicant: GALDERMA S.A.Inventors: Alexandre KAOUKHOV, Christophe VILLARD, Philippe BOUISSOU
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Patent number: 7514094Abstract: A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a haloalkyl group, m is 0 or 1, and Q is or a substituted or unsubstituted heterocyclic group, (wherein X is an oxygen atom or a sulfur atom, R1 and R2 are respectively independently a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted cycloalkyl group, and the like.Type: GrantFiled: February 1, 2007Date of Patent: April 7, 2009Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Masayuki Morita, Mitsugu Iwasa
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Publication number: 20090075918Abstract: Veterinarian composition comprising an organic salt of levamisole in combination with at least one avermectine and/or milbemycine. A veterinarian formulation comprising of organics salts of levamisole, more specifically to the disophenolat salt of levamisole and the nitroxynil-salt of levamisole with avermectines and milbemycines and its use in treatment of helminthiasis in mammals, in particular in bovines, swines, caprines, equines, ovines, canines and felines.Type: ApplicationFiled: December 18, 2006Publication date: March 19, 2009Inventors: Dolivar Coracci Neto, Nelson Henriques Fernandes Filho, Ricardo da Silva Sercheli
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Publication number: 20090042815Abstract: This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: ApplicationFiled: July 26, 2007Publication date: February 12, 2009Applicant: Intervet International B.V.Inventors: Fritz Blatter, Meinrad Brenner, Monika Brink, Kerstin Fleischhauer, Guixian Hu, Hans Peter Niedermann, Timo Rager, Tanja Schweisel, Stephan Veit, Ralf Warrass, Heinz-Jorg Wennesheimer
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Publication number: 20080248998Abstract: Composition intended for the oral administration of active principles with unacceptable taste, which comprises from about 15% to about 30% of organoleptically unpleasant active ingredient (principle) that is mixed with from about 60% to about 80% of an ester of glycerol or of a fatty acid, to which a wax is optionally added and to which a surfactant is added, and in that it is prepared by a spray-cooling process which can produce a particle size of less than 350 ?m.Type: ApplicationFiled: June 16, 2008Publication date: October 9, 2008Applicant: AVENTIS PHARMA SAInventors: Isabelle CHACORNAC, Patricia PROBECK
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Publication number: 20080194498Abstract: Described is a compound of the formula (1) wherein the bond between carbon atoms 22 and 23 is a single or double bond; m is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and either (A) R2 is —N(R3)R4, and (1) X is 0, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, mono- to pentasubstituted C1-C12alkyl, unsubstituted or mono- to pentasubstituted C3-C12cycloalkyl; or (2) X is S, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl; or (3) X is 0 or S, wherein R3 and R4 together are, for instance, a three- to seven membered alkylene or a four- to seven-membered alkenylene bridge; or (B) R2 is OR5, X is 0 or S, wherein R5 is, for instance, C1-C12alkyl, mono- to pentasubstituted C1-C12alkyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof, in each case in free form orType: ApplicationFiled: August 27, 2004Publication date: August 14, 2008Inventors: Fiona Murphy Kessabi, Thomas Pitterna, Peter Maienfisch, Jerome Cassayre, Laura Quaranta, Pierre Jung, Ottmar Franz Hueter
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Patent number: 7396820Abstract: The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus hexahydropyrazinoisoquinolines, tetrahydropyrimidines and benzimidazoles or febantel. Examples of hexahydropyrazinoisoquinolines, tetrahydropyrimidines and benzimidazoles include praziquantel, pyrantel pamoate and fenbendazole, respectively. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm, whipworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.Type: GrantFiled: March 12, 2004Date of Patent: July 8, 2008Assignees: Virbac Corporation, The Hartz Mountain CorporationInventors: Ian Cottrell, Arima Das Nandy, Albert Ahn, Richard Fisher
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Patent number: 7396819Abstract: The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus hexahydropyrazinoisoquinolines and tetrahydropyrimidines. Examples of these include praziquantel and pyrantel. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.Type: GrantFiled: August 8, 2003Date of Patent: July 8, 2008Assignees: Virbac Corporation, The Hartz Mountain CorporationInventors: Michael Burke, Vinay Tripathi, Albert Ahn, Ian Cottrell
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Publication number: 20080161249Abstract: The present invention relates to the use of novel antibacterial compounds, and pharmaceutical compositions containing these compounds.Type: ApplicationFiled: November 17, 2005Publication date: July 3, 2008Applicant: SMITHKLINE BEECHAM CORPORATIONInventor: Jianzhong Huang
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Patent number: 7378399Abstract: What is described are a compound of the formula (I) Wherein A-B is —CH?CH— or —CH2—CH2—; n is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and R3 for instance are either, (i) independently from each other for instance -Q, —C(?Y)-Q, or —C(?Y)—O-Q; or (ii) together form with the nitrogen atom to which they are bound a three- to seven-membered ring, (iii) together are ?C(R4)R5; R4 and R5 are, independently from each other, for instance -Q, —C(?Y)-Q, or —C(?Y)—O-Q; Y is O or S; Q is for instance H or unsubstituted or mono- to pentasubstituted C1-C12alkyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof; a process for preparing these compounds, their isomers and tautomers and the use of these compounds, their isomers and tautomers; pesticidal compositions whose active compound is selected from these compounds and their tautomers; intermediates for the preparation of the said compounds of the formula (I), methods for the preparation of the compounds of the formula (Type: GrantFiled: February 3, 2004Date of Patent: May 27, 2008Assignee: Merial LimitedInventors: Jerome Cassayre, Hans Tobler, Thomas Pitterna, Peter Maienfisch, Fiona Murphy Kessabi, Laura Quaranta, Ottmar Franz Hueter
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Patent number: 7368435Abstract: A topical formulation having significant parasiticidal activity effective against endoparasites and/or ectoparasites such as heartworms, mites, fleas, ticks, flies is provided, which can be safe to use and avoids the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of a macrocyclic lactone, a neo-nicotinoid and optionally, an insect growth regulator. The topical formulation can be packaged together or packaged so that the macrocyclic lactone and the neo-nicotinoid are stored separately prior to administering the topical insecticide formulation to the animal.Type: GrantFiled: September 7, 2005Date of Patent: May 6, 2008Assignee: Summit Vetpharm, LLCInventors: Ian W. Cottrell, Albert Ahn, Richard Fisher
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Patent number: 7282487Abstract: The invention relates to methods of treating a bacterial infection in a horse or a pig. The method involves administering to the horse or pig a composition comprising (i) a salt made from tilmicosin and a lipophilic acid and (ii) a pharmaceutically acceptable solvent combined together to form an injectable composition that precipitates when injected into water.Type: GrantFiled: October 28, 2004Date of Patent: October 16, 2007Assignee: Idexx LaboratoriesInventor: Yerramilli V. S. N. Murthy
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Patent number: 7250402Abstract: A compound represented by the general formula (I) or a salt thereof: wherein represents —CH?CH—, —CH2—CH2— or the like, between R1 and the carbon atom at 4?-position represents a single bond or a double bond, between R2 and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) when represents —CH?CH— or —CH2—CH2—, and between R1 and the carbon atom at 4?-position represents a double bond, R1 represents ?C(R11)(R12) (wherein R11 represents a lower alkyl group or the like and R12 represents a hydrogen atom or the like) or the like, and R2 represents a hydroxyl group or the like, or R2 may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) when represents —CH?CH— or —CH2—CH2—, and between R1 and the carbon atom at 4?-position represents a single bond, R1 represents —OCH(R1a)(R1b) (wherein R1a represents a lower alkyl or the like and R1b represents a hydrogen atom or the like) or the like, and R2 reType: GrantFiled: November 29, 2004Date of Patent: July 31, 2007Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kenichiro Nagai, Toshiaki Sunazuka
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Patent number: 7247617Abstract: Sixteen membered macrolide anti-infective agents having a structure according to formula I where R1, R2, R3, R4, R5, and R6 are as defined herein, and related compounds are disclosed.Type: GrantFiled: June 15, 2005Date of Patent: July 24, 2007Assignee: Kosan Biosciences IncorporatedInventors: Hong Fu, Leonard Katz, David C. Myles
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Patent number: 7195773Abstract: A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a haloalkyl group, m is 0 or 1, and Q is or a substituted or unsubstituted heterocyclic group, (wherein X is an oxygen atom or a sulfur atom, R1 and R2 are respectively independently a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted cycloalkyl group, and the like.Type: GrantFiled: October 22, 2001Date of Patent: March 27, 2007Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Masayuki Morita, Mitsugu Iwasa
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Patent number: 7144866Abstract: Provided is a compound represented by the general formula (I) or a salt thereof: wherein, —XY— represents —CH?CH— and the like, between R2 and the carbon atom at 5-position represents a single bond or a double bond, R1 represents a lower alkyl group, a formyl group, a carboxyl group, a lower alkoxycarbonyl group (wherein a lower alkyl moiety of said lower alkoxycarbonyl group may be substituted with a heterocyclic group) and the like, and R1a represents a hydrogen atom, provided when R1 represents a lower alkoxycarbonyl group and the like, R1a may further represents a lower alkoxycarbonyl group and the like, when between R2 and the carbon atom at 5-position is a single bond, R2 represents a hydroxyl group and the like, and when between R2 and the carbon atom at the 5-position is a double bound, R2 combines with the carbon atom at 5-position to form a hydroxime group (—C(?NOH)) and the like, and R3 represents a hydroxyl group or a tri(lower alkyl)silyloxy group.Type: GrantFiled: August 8, 2001Date of Patent: December 5, 2006Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kenichiro Nagai, Toshiaki Sunazuka
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Patent number: 7119076Abstract: A drug effective for prevention and therapy of endometriosis and hysteromyoma is disclosed. The drug for prevention and/or therapy of endometriosis and/or hysteromyoma according to the present invention comprises as an effective ingredient a macrolide antibiotic.Type: GrantFiled: November 15, 2001Date of Patent: October 10, 2006Inventor: Masao Sugamata
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Patent number: 7094431Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide; (b) calcium channel blocker, and (c) fat-soluble vitamins admixed with antibacterial and antifungal agents. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products and administered orally or topically.Type: GrantFiled: September 30, 2003Date of Patent: August 22, 2006Inventor: Mickey L. Peshoff
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Patent number: 7064108Abstract: A topical gel composition comprising between about 0.005 and 1.0% ivermectin, between about 30 and 40% of a pharmaceutically acceptable alcohol, between about 30 and 40% of a pharmaceutically acceptable glycol, and a pharmaceutically acceptable carrier, useful for treating Pediculosis capitis infestation in a human patient.Type: GrantFiled: February 4, 2003Date of Patent: June 20, 2006Assignees: Merck & Co., Inc., McNeil-PPC, Inc.Inventors: Cynthia A. Guzzo, Coleen M. Clineschmidt, George Schorn, James M. Reynolds
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Patent number: 7037523Abstract: The present invention provides a controlled release pharmaceutical composition of an acid labile, poorly soluble drug having pH dependent solubility profile in aqueous environment. In a preferred embodiment the drug is combined with a practically water insoluble polymer an optimizing agent and optional additives to produce a controlled release of therapeutic agent when compositions is exposed to aqueous environment.Type: GrantFiled: November 1, 2002Date of Patent: May 2, 2006Assignee: Wockhardt LimitedInventors: Javed Hussain, Pankaj Khapra, Arun S. Gosavi
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Patent number: 7001889Abstract: This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agent contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent.Type: GrantFiled: June 21, 2002Date of Patent: February 21, 2006Assignee: Merial LimitedInventors: Keith Freehauf, Maryam Moaddeb
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Patent number: 6998131Abstract: In particular this invention provides for spot-on compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (1) a composition comprising (A) an effective amount of a 1-phenylpyrazole derivative; and (B) an effective amount of emamectin; (2) an acceptable liquid carrier vehicle; and (3) optionally, a crystallization inhibitor. The invention also provides for a method of treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal or bird an effective amount of a composition according to the present invention.Type: GrantFiled: October 24, 2002Date of Patent: February 14, 2006Assignee: Merial LimitedInventors: Mark D. Soll, Albert Boeckh
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Patent number: 6991801Abstract: This invention provides for inter alia, topical anthelmintic formulations which comprise a pharmaceutically active combination consisting of at least one macrocyclic compound and at least one compound selected from the group consisting of praziquantel, morantel and pyrantel, which are dissolved in a non-aqueous solvent or solvent mixture and optionally a thickening agent.Type: GrantFiled: April 5, 2004Date of Patent: January 31, 2006Assignee: Merial LimitedInventors: Mark D. Soll, Krishan Kumar, Robert P. Waranis, Natalya Shub
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Patent number: 6962713Abstract: In particular this invention provides for spot-on compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (1) a composition comprising (A) an effective amount of a 1-phenylpyrazole derivative; and/or (B) an effective amount of a macrocyclic lactone antihelmintic or antiparasitic agent; (2) an acceptable liquid carrier vehicle; and (3) optionally, a crystallization inhibitor. The invention also provides for a method of treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal or bird an effective amount of a composition according to the present invention.Type: GrantFiled: May 24, 2002Date of Patent: November 8, 2005Assignee: MerialInventors: Anne-Marie Huet, Bruno Julia, Jean-Pierre Etchegaray, André Weil, Philippe Jeannin
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Patent number: 6919317Abstract: Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro, 33-desoxyascomycin are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in conditions in which fungal or suspected fungal colonisation of e.g. the skin plays a role, such as atopic dermatitis and seborrhoeic dermatitis, and in situations of fungal resistance.Type: GrantFiled: February 16, 2001Date of Patent: July 19, 2005Assignee: Novartis AGInventors: Neil Stewart Ryder, Friedrich Karl Mayer
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Patent number: 6914051Abstract: A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an antibiotic compound and a mobilizing agent in an amount sufficient to enable the antimicrobial compound to penetrate into the sub-dermal soft tissues. The antimicrobial compound may be a macrolide antibiotic compound such as azithromycin, erythromycin or roxithromycin, for example, and the mobilizing agent may be an organogel compound, such as pluronic lecithin liposomal organogel (PLO). The composition may further include a penetration enhancing adjuvant, such as d-limonene, for example. The composition may be applied topically so as to penetrate into the sub-dermal soft tissues, or may injected so as to be absorbed into the soft tissues locally.Type: GrantFiled: June 28, 2001Date of Patent: July 5, 2005Inventor: David M Allen
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Patent number: 6903052Abstract: The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes that parasitize animals can also be controlled using the methods and composition of this invention. Certain of the useful compounds are fatty acid esters that are predicted inhibitors of nematode delta-12 fatty acid desaturases and can be, for example, from C16 to C20 in length.Type: GrantFiled: July 1, 2002Date of Patent: June 7, 2005Assignee: Divergence, Inc.Inventors: Deryck J. Williams, Andrew P. Kloek, Michelle Coutu Hresko
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Patent number: 6893652Abstract: A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treating and controlling endoparasiticidal infection and infestation in a homeothermic animal.Type: GrantFiled: July 24, 2002Date of Patent: May 17, 2005Assignee: WyethInventors: Shobhan S. Sabnis, Jon Hayes, Jack A. Zupan
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Patent number: 6872708Abstract: A local injection prescription that disperses a malignant tumor to decrease the size of the tumor or terminate the tumor. The local injection prescription is produced by dissolving an organic compound having a lactone nucleus in lower alcohol and water.Type: GrantFiled: April 7, 2003Date of Patent: March 29, 2005Inventors: Mitsukazu Matsumoto, Hisatake Ishikawa, Hirohiko Matsumoto
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Patent number: 6764999Abstract: A method to treat an animal in need thereof with one or more parasiticides by administering those one or more parasiticides to the nasal pharynx of the animal. A method to increase an animal's blood levels of one or more avermectin compounds/milbemycin compounds such that the blood levels of those one or more avermectin compounds/milbemycin compounds reach a maximum concentration in about 24 hours, and such that those blood levels exceed about 2 ng/ml for at least 96 hours post administration.Type: GrantFiled: July 11, 2002Date of Patent: July 20, 2004Inventors: Stephen E. Bachman, Michael E. Hubbert
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Patent number: 6756369Abstract: The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.Type: GrantFiled: March 19, 2002Date of Patent: June 29, 2004Assignee: Vanderbilt UniversityInventors: William M. Mitchell, Charles W. Stratton
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Patent number: 6746677Abstract: The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solvent; and saline or water or mixtures thereof. The invention further relates to stable compositions as described above of a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof, but without an antigen. The invention also relates to a method for preventing or controlling helminthiasis, infection by acarids and arthropod endo-and ectoparasites and bacterial and viral disease in warm-blooded animals by the parenteral administration of compositions of the invention. The invention further relates to a process for the preparation of the invention compositions.Type: GrantFiled: October 8, 1999Date of Patent: June 8, 2004Assignee: American Cyanamid CompanyInventors: Ramune Marija Cobb, Christopher Leigh Schwartzkoff
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Patent number: 6710034Abstract: There are described novel 5-O-mycaminosyltylonide derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.Type: GrantFiled: April 19, 2002Date of Patent: March 23, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Ly Tam Phan, Nha Vo, Yat Sun Or, Yao-Ling Qiu, Ying Hou
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Patent number: 6680299Abstract: There are described novel 4′ substituted 16-membered macrolides and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.Type: GrantFiled: July 27, 2001Date of Patent: January 20, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yat Sun Or, Ly Tam Phan, Zhaolin Wang, Tianying Jian