Plural Oxygens Patents (Class 514/718)
  • Patent number: 7674817
    Abstract: The antimicrobial acid-catalyzed coating composition of the invention is an acid-catalyzed coating composition formulated with at least one antimicrobial agent to provide antimicrobial activity to the coating composition and an article coated therewith.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: March 9, 2010
    Assignee: Akzo Nobel Coatings International B.V.
    Inventor: James H. Bray, III
  • Publication number: 20090311354
    Abstract: The present invention relates to a composition for the prevention and treatment of inflammatory disease containing the extracts of Magnolia obovata or fractions thereof as an active ingredient, more precisely, a composition for the prevention and treatment of inflammatory disease containing the extracts of Magnolia obovata fruits and floral buds extracted with alcohol or alcohol aqueous solution as a solvent and active fractions isolated from the same. The extracts and fractions of the present invention inhibit lipopolysaccharide (LPS) induced nitric oxide (NO) generation significantly, have anti-inflammation activity and low cytotoxicity, and contain all of major effective components isolated from Magnolia obovata such as obovatol, honokiol and magnolol, so that they can be effectively used for the prevention and treatment of inflammatory disease.
    Type: Application
    Filed: August 26, 2008
    Publication date: December 17, 2009
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Byoung-Mog KWON, Dong Cho HAN, Hye-Nan KIM, Young-Min HAN, So Young LEE, Dae-Seop SHIN
  • Publication number: 20090311291
    Abstract: The present disclosure provides improved packaged condoms that enable the use of a large quantity of a composition inside the condom. In addition, a sufficient quantity of certain spermicidal and/or microbicidal compositions is provided for efficient inactivation of sperm and pathogens. The present disclosure also provides condoms with reduced tendency to slip or break. Compositions associated with different surfaces of the condom can be effectively segregated to their intended condom surface according to the present disclosure.
    Type: Application
    Filed: July 3, 2007
    Publication date: December 17, 2009
    Applicant: REPROTECT, INC.
    Inventor: Thomas R. Moench
  • Publication number: 20090304769
    Abstract: Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
    Type: Application
    Filed: June 4, 2007
    Publication date: December 10, 2009
    Inventors: Eric J. Kunkel, Evangelos Hytopoulos, Ivan Plavec
  • Patent number: 7579494
    Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: August 25, 2009
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Charles N. Serhan
  • Publication number: 20090202633
    Abstract: The present invention relates to extended release formulations comprising expectorant. More particularly, the present invention relates to extended release formulations comprising guaifenesin. The present invention also relates to a process for the preparation of extended release formulations comprising guaifenesin.
    Type: Application
    Filed: January 2, 2009
    Publication date: August 13, 2009
    Inventors: Siva Ramakrishna Velaga, Saravanan Kannusamy, Madhu Kandukuri, Venkata Ram Mohan Rao Visinigiri, Nagaprasad Vishnubhotta, Sivakumaran Meenakshisunderam
  • Publication number: 20090203653
    Abstract: The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The invention also provides novel kits comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor compound, and, optionally, at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating gastrointestinal disorders; (h) treating inflammatory disorders; and (j) treating respiratory disorders. The apocynin compound may preferably be apocynin. The nitric oxide donor compound may preferably be isosorbide dinitrate and/or isosorbide mononitrate.
    Type: Application
    Filed: October 3, 2005
    Publication date: August 13, 2009
    Applicant: NITROMED, INC.
    Inventor: David S. Garvey
  • Publication number: 20090196939
    Abstract: A method for antimicrobial treatment (e.g. antimicrobial treatment of food packaging and equipment) comprising applying to microbes a composition containing a diluting solvent (e.g., water), an antimicrobially-active solvent having a density different from the density of the diluting solvent, and an optional cosolvent, surfactant, or additional antimicrobial agent, wherein the amount of antimicrobially-active solvent or additional antimicrobial agent is sufficiently high and the amount of cosolvent or surfactant is sufficiently low so that the composition will provide greater than a 1-log order reduction in the population of bacteria or spores of Bacillus cereus within 10 seconds at 60° C. Preferred methods of the invention employ compositions containing an additional antimicrobial agent such as peroxyacetic acid. Compositions for use in the method can be prepared as concentrates, and used full strength or in diluted form.
    Type: Application
    Filed: February 9, 2009
    Publication date: August 6, 2009
    Applicant: ECOLAB INC.
    Inventors: Robert D.P. Hei, Guang-jong J. Wei, David A. Halsrud, Kim R. Smith, Teresa C. Podtburg
  • Patent number: 7560491
    Abstract: A series of Z-stilbenes derivatives are disclosed, which have the structure as shown by formula 1. In the structure of formula 1, X is hydrogen, NHR, or nitro group, and R is hydrogen. Y and Z is independently hydrogen, halogen, C1-C10 alkyl, or C1-C10 alkoxyl. Furthermore, A is hydrogen, hydroxyl, or amino group. The compounds of the present invention have both aqueous solubility and anti-tumor activity. The Z-stilbenes derivatives of the present invention can further include a pharmaceutical carrier to form pharmaceutical compositions as potent anti-mitotic agents and anti-cancer agents.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: July 14, 2009
    Assignees: Taipei Medical University, National Health Research Institutes
    Inventors: Jing-Ping Liou, Jang-Yang Chang
  • Patent number: 7560119
    Abstract: Methods of treating acne include the use of formulations including a benzoyl peroxide solution and an antioxidant.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: July 14, 2009
    Assignee: JR Chem, LLC
    Inventors: Joseph R. Faryniarz, Jose E. Ramirez
  • Patent number: 7556820
    Abstract: Benzoyl peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions. Treatment of truncal acne vulgaris with a combination of actives, namely benzoyl peroxide and salicylic acid, is provided via regimens that include applying such benzoyl peroxide compositions to an area of the body afflicted with acne, after a waiting period rinsing the benzoyl peroxide-treated area (e.g., by showering), drying the rinsed area, and then applying a topical, at least partially neutralized salicylic acid composition to the afflicted area.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: July 7, 2009
    Assignee: JR Chem, LLC
    Inventors: José E. Ramirez, Joseph R. Faryniarz
  • Patent number: 7557145
    Abstract: This invention relates to the use of eugenol and/or eugenol derivatives for inhibiting the asexual propagation of fungi. This invention also relates to filter media, adhesives, building materials, building auxiliaries, textiles, pelts, paper, skins or leather, laundry detergents, cleaning compositions, rinse agents, hand washing preparations, manual dishwashing detergents, machine dishwashing detergents and preparations for finishing building materials, building auxiliaries, textiles, pelts, paper, skins or leather that contain eugenol and/or eugenol derivatives and to preparations for treating building materials, building auxiliaries, textiles, pelts, paper, skins or leather that contain eugenol and/or eugenol derivatives.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: July 7, 2009
    Assignee: Henkel Kommanditgesellschaft auf Aktien (Henkel KGAA)
    Inventors: Mirko Weide, Anja Schloesser, Dirk Bockmuehl, Andreas Bolte, Roland Breves
  • Publication number: 20090155180
    Abstract: The present invention provides methods for identifying genes, expression regulators, receptors, protein product receptors, and proteins that may regulate rhinovirus infections. The genes identified may be used as markers for disease onset and progression and to measure efficacy of a therapeutic. The present invention also provides methods to screen agents that are capable of regulating rhinovirus infection. The present invention also provides methods of identifying therapeutic compounds that may treat various disorders by regulating the expression and activity of genes, expression regulators, receptors, protein product receptors, and proteins identified.
    Type: Application
    Filed: February 28, 2008
    Publication date: June 18, 2009
    Inventors: Mary Lynn Jump, Jeffrey Warren Clymer, Begonia Y. Ho, Amy Ann Walanski, Cynthia E. Francis
  • Publication number: 20090148426
    Abstract: The present invention relates to a composition for life extension, comprising reduced coenzyme Q10 as an active ingredient, as well as relates to a method of extending a life span using the composition comprising reduced coenzyme Q10 as an active ingredient. In the present invention, it has been found that long-term ingestion of feed that contains reduced coenzyme Q10 enables the life span of senescence-accelerated model mice to be extended. No sign indicating toxicity is observed in the senescence-accelerated model mice that have been fed with reduced coenzyme Q10 over a long period. Based on these findings, it was found that the composition containing reduce coenzyme Q10 as an active ingredient has potential to be a composition for life extension with high safety, capable of being taken for a long period.
    Type: Application
    Filed: September 21, 2006
    Publication date: June 11, 2009
    Applicant: KANEKA CORPORATION
    Inventors: Hideyuki Kishida, Taizuo Kawabe, Kazunori Hosoe
  • Publication number: 20090143295
    Abstract: Peptide-based antiacne reagents, formed by coupling a skin-binding peptide with an antiacne agent, are described. The skin-binding peptide portion of the peptide-based antiacne reagent binds strongly to the skin, thus keeping the antiacne agent coupled to the skin for a long lasting effect. Skin care compositions comprising the peptide-based antiacne reagents are also provided as well as a method of treating or preventing skin acne.
    Type: Application
    Filed: November 19, 2008
    Publication date: June 4, 2009
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: JOHN P. O'BRIEN, Hong Wang, Antoinette E. Wilkins
  • Publication number: 20090142425
    Abstract: A physiologically active composition is claimed which comprises effective amounts of at least one compound from the group 4-O-methyldavidigenin, 4?-O-methyldavidigenin, davidigenin, elemicin, isoelemicin, herniarin, demethoxycapillarisin, in particular 6-demethoxycapillarisin and/or 6-demethoxy-3?-methoxy-capillarisin, hispiludin and 9-hydroxy-10E, 12Z, 15Z-octadecatrienoic acid, and also glycosides thereof, in particular glucosides and/or rhamnoglucosides of 4-O-methyldavidigenin and/or 4?-O-methyldavidigenin, salts and derivatives.
    Type: Application
    Filed: July 21, 2005
    Publication date: June 4, 2009
    Inventors: Ralf Jager, Hans-Henning Wenk, Heike Tom Dieck, Hans Ullrich Hoppe, Roland Rabeler
  • Publication number: 20090137687
    Abstract: This invention relates to novel tricyclic quinone and catechol compositions, compositions containing prodrugs of tricyclic quinone and catechol compositions, and methods of use for the treatment of solid tumor cancers and other vascular proliferative disorders. In certain aspects, the compositions of the invention are capable of generating both a vascular targeting effect and tumor cell cytotoxicity (e.g., by oxidative stress) in order to achieve an enhanced anti-tumor response in a patient.
    Type: Application
    Filed: June 19, 2008
    Publication date: May 28, 2009
    Applicants: OXiGENE, Inc., Baylor University
    Inventors: David Chaplin, Kevin G. Pinney, Peter Wardman, Vani P. Mocharla, Lisa K. Folkes
  • Publication number: 20090130159
    Abstract: It is an object of the present invention to provide a nanoparticle containing a microbicide and a biodegradable polymer, which is safe and excellent in terms of dispersion stability and has high transparency and good absorbability due to its small particle size. The present invention provides a water-dispersible nanoparticle, which comprises a microbicide and a biodegradable polymer.
    Type: Application
    Filed: November 14, 2008
    Publication date: May 21, 2009
    Applicant: FUJIFILM Corporation
    Inventor: Kazutaka OGIWARA
  • Patent number: 7524875
    Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: April 28, 2009
    Assignee: NOF Corporation
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Patent number: 7514097
    Abstract: (1) A tissue-covering medical material which comprises a soluble cellulose derivative having been made hardly soluble in water, which is used with a purpose of being embedded in the body or applied to the tissue, and (2) a method for producing the tissue-covering medical material as defined in (1), which comprises, as a method to make a soluble cellulose derivative hardly soluble in water, freezing and thawing an acidic solution of the soluble cellulose derivative, are provided.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: April 7, 2009
    Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yasukazu Himeda, Toshihiko Umeda
  • Patent number: 7510704
    Abstract: This invention concerns cosmetic compositions and methods involving 4-hydroxy-3-methoxybenzyl alcohol as an active ingredient. This material is shown to be an extremely effective sub-lethal inhibitor of the metabolism of selected corynebacteria and to give significant deodorancy benefits.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: March 31, 2009
    Assignee: Unilever Home & Personal Care USA division of Conopco, Inc.
    Inventors: Diana Sheila Cox, Alexander Gordon James, David Taylor
  • Publication number: 20090082471
    Abstract: The present application describes deuterium-enriched fingolimod, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 26, 2009
    Applicant: PROTIA, LLC
    Inventor: Anthony W. Czarnik
  • Publication number: 20090075943
    Abstract: Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 19, 2009
    Inventors: Kevin G. PINNEY, Madhavi Sriram
  • Publication number: 20090069443
    Abstract: It is intended to provide a sedative effect-imparting agent that provides excellent sedative effect with good fragrance-releasing property, and is possible to provide the excellent sedative effect immediately. The sedative effect-imparting agent according to the present invention provides excellent sedative effect immediately, since it consists of dimethoxybenzene that provides excellent sedative effect with good fragrance-releasing property.
    Type: Application
    Filed: April 12, 2006
    Publication date: March 12, 2009
    Applicant: Shiseido Co., Ltd.
    Inventors: Keiko Mori, Yushi Terajima, Katsuyuki Yomogida, Masanori Yoshimura, Shinichiro Haze
  • Publication number: 20090011059
    Abstract: The present invention relates to the use of a ginger extract on its own or in combination with pharmaceutical compositions for inhibiting human drug transporters for positively influencing the oral bioavailability and pharmacokinetics of active substances.
    Type: Application
    Filed: December 20, 2006
    Publication date: January 8, 2009
    Inventors: Naoki Ishiguro, Wataru Kishimoto, Thomas Ebner, Willy Roth
  • Patent number: 7473711
    Abstract: The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker
  • Patent number: 7445729
    Abstract: Organic peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: November 4, 2008
    Assignee: JR Chem, LLC
    Inventors: Joseph R. Faryniarz, Jose E. Ramirez
  • Patent number: 7432305
    Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: October 7, 2008
    Assignee: Edison Pharmaceuticals, Inc.
    Inventors: Guy M. Miller, Sidney M. Hecht
  • Publication number: 20080207713
    Abstract: The present invention is directed to compounds, combinations, compositions and methods for enhancing nitric oxide (NO) delivery to target sites, and in particular to muscle, both normal and dystrophic. Enhanced NO delivery according to the present invention may be achieved by using a combination of a muscle relaxant and an NO donor compound, or by using a compound of the invention: formula (I) wherein R1 is H, halo, C1-6 alkoxy or C1-6 alkyl; R2 is H, NO2 or C(O)NH2; R3 is H, NO2 or C(O)NH2; and at least one of R2 and R3 is NO2; or a pharmaceutically acceptable salt of the compound.
    Type: Application
    Filed: June 8, 2006
    Publication date: August 28, 2008
    Inventors: Gu-Qi Wang, Frank J Burczynski, Judith E Anderson
  • Patent number: 7390431
    Abstract: Organic peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: June 24, 2008
    Assignee: JR Chem, LLC
    Inventors: Joseph R. Faryniarz, Jose E. Ramirez
  • Patent number: 7364751
    Abstract: The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: April 29, 2008
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20080085312
    Abstract: Formulations have been developed administering a guaiacolsulfonate salt, preferably potassium salt, in multi-phases. In a preferred embodiment, the formulation contains potassium guaiacolsulfonate in an immediate release (“IR”) form and a sustained or delayed release (“DR”) form and/or pulsed release (“PR”) form. In another embodiment, the potassium guaiacolsulfonate is released in a gradient, decreasing the side effects associated with rapidly elevated blood levels. In another embodiment, the drug is bound to an ion-exchange resin, which can be suspended in a liquid or incorporated into a matrix for delayed, sustained and/or pulsed release. Dosage unit forms may be tablets, gels, liquids, capsules, beads, microparticles, films or lozenges. Multi-phase delivery can also be achieved through the use of a kit that provides for dosage escalation. The formulations are useful in the treatment of one or more symptoms of coughs, colds, sinusitis and other respiratory illnesses.
    Type: Application
    Filed: February 28, 2007
    Publication date: April 10, 2008
    Inventors: Glynn Wilson, Matthew F. Heil
  • Patent number: 7307071
    Abstract: Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bcr-Abl tyrosine kinase, imatinib.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: December 11, 2007
    Assignee: Onyx Pharmaceuticals, Inc
    Inventors: John F. Lyons, Gideon Bollag
  • Patent number: 7268165
    Abstract: Antimicrobial compositions which can be used wherever disinfecting compositions are needed, such as in a hospital, healthcare industry, workplace, recreational facility, home or similar environment. The antimicrobial compositions are particularly useful as a topical application for a substrate, such as skin and can be used as a hand sanitizer or pre-surgical scrub. The compositions comprise a synergistic combination of a simple aliphatic alcohol and an activity enhancing substance, wherein the composition provides, heretofore unexpected, persistent activity against a broad range of microorganisms, including gram-negative organisms, while moisturizing the skin.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: September 11, 2007
    Assignee: Steris Inc.
    Inventors: Zachariah C. Greten, Nancy-Hope E. Kaiser, Daniel A. Klein
  • Patent number: 7227031
    Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: June 5, 2007
    Assignee: The Brigham and Women's Hospial, Inc.
    Inventor: Charles N. Serhan
  • Patent number: 7163950
    Abstract: According to the first aspect of the invention, a composition for reversing malarial resistance to quinolines is disclosed. The composition includes a surfactant, such as nonylphenolethoxylate (NPE) in an admixture with a pharmaceutically acceptable carrier, excipient, or diluent. According to a second aspect of the invention, a composition for the prevention or treatment of malaria is provided. The composition comprises a pharmaceutically effective amount of a quinoline in combination with a surfactant, such as NPE, for reversing malarial resistance to quinolines. According to a third aspect of the invention, a method of preventing or treating malaria in a person is provided. The method comprises administering to a patient in need thereof one or both of the compositions described above.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 16, 2007
    Assignee: University Health Network
    Inventors: Kevin C. Cain, Ian Crandall, Jeffrey Charuk, Reinhart Reithmeier
  • Patent number: 7119123
    Abstract: Antimicrobially active 4-methyl-4-aryl-2-pentanols of the Formula 1 below, methods for the preparation of these compounds and their use as antimicrobial active compounds are described. Surprisingly, compounds of the Formula 1 for which: R=hydrogen, hydroxyl, alkoxy group with up to 10 C atoms, straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms, alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge, fluorine, chlorine, bromine, iodine, or alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms, have proved to be antimicrobially active.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: October 10, 2006
    Assignee: Symrise GmbH & Co. KG
    Inventors: Gerhard Schmaus, Holger Joppe
  • Patent number: 7074829
    Abstract: This invention relates to new antiestrogens of the general formula in which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens). Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: July 11, 2006
    Assignee: Schering AG
    Inventors: Ulrich Klar, Rolf Bohlmann, Karsten Parczyk, Karl-Heinrich Fritzemeier, Monika Lessl, Rosemarie Lichtner
  • Patent number: 7056862
    Abstract: The invention provides an agricultural chemical enhancer and an agricultural chemical composition which are safely used for crops without any phytotoxicity, have a potency enhancing action on various agricultural chemicals and promote the growth of a plant body to be intended to be grown. The invention relates to an agricultural chemical enhancer comprising at least one type selected from a specific alcohol compound, an ether compound and an ester compound.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: June 6, 2006
    Assignee: Kao Corporation
    Inventors: Toshio Hayashi, Tadayuki Suzuki, Kazuhiko Kurita
  • Patent number: 7045660
    Abstract: This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. The present invention is therefore directed to their pharmacological use for inhibiting TNF and/or cyclic AMP phosphodiesterase, pharmacological compositions comprising the compounds and methods for their preparation.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: May 16, 2006
    Assignee: Aventis Pharma Limited
    Inventors: Garry Fenton, Tahir Nadeem Majid, Malcolm Norman Palfreyman
  • Patent number: 6949557
    Abstract: The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hydroanthracene based compounds for the inhibition and/or prevention of cancer of the colon, pancreas, prostate, lung, larynx, ovary, breast, glioblastoma, oral cavity, endothelial cells and leukemias. The agents of the invention form a distinct class, distinct from the anthracene, anthrone or anthraquinone derivatives.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: September 27, 2005
    Assignee: Dabur Research Foundation
    Inventors: Asish Kumar Banerjee, Venkatachalam Sesha Giri, Rama Mukherjee, Kamal K. Kapoor, Gautam Desiraju, Manu Jaggi, Anu T. Singh, Sankar Kumar Dutta, Kalapatapu V. V. M. Sairam
  • Patent number: 6946484
    Abstract: Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: September 20, 2005
    Assignee: Cellegy Pharmaceuticals, Inc.
    Inventors: Michael A. Adams, Charles H. Graham, Jeremy P. W. Heaton, Lynne-Marie Postovit
  • Patent number: 6933320
    Abstract: An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum compounds, epidophylloptoxins, and antibiotics as the active ingredients is provided. Methods of using these pharmaceutical preparations for the treatment of solid carcinomas and the like are also provided.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: August 23, 2005
    Assignee: Aventis Pharma S. A.
    Inventor: Marie-Christine Bissery
  • Patent number: 6899901
    Abstract: The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: May 31, 2005
    Assignees: Takasago International Corporation, Takasago International Corporation (USA)
    Inventors: Tetsuo Nakatsu, Peter J. Mazeiko, Andrew T. Lupo, Jr., Carter B. Green, Charles H. Manley, David J. Spence, Hideaki Ohta
  • Patent number: 6890567
    Abstract: The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: May 10, 2005
    Assignees: Takasago International Corporation, Takasago International Corporation (USA)
    Inventors: Tetsuo Nakatsu, Peter J. Mazeiko, Andrew T. Lupo, Jr., Carter B. Green, Charles H. Manley, David J. Spence, Hideaki Ohta
  • Patent number: 6855341
    Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: February 15, 2005
    Inventor: Jeffrey B. Smith
  • Publication number: 20040259958
    Abstract: Antimicrobial compounds, compositions containing the same, and methods of using of the same for reducing the presence of microorganisms on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated phenoxy and/or benzyloxy substituted phenol compounds.
    Type: Application
    Filed: June 14, 2004
    Publication date: December 23, 2004
    Inventors: David Scott Harper, robert A. Coburn, Constantine Georgiades, Andre Soshinsky, Marianne D. Huntley
  • Publication number: 20040254252
    Abstract: Disclosed are pharmaceutical and cosmetic compositions containing as active ingredients a combination of at least one oxy group-bearing aromatic aldehyde compound and an additional cosmetically or pharmaceutically effective agent. Uses of these compositions are also disclosed.
    Type: Application
    Filed: May 14, 2004
    Publication date: December 16, 2004
    Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
  • Publication number: 20040248991
    Abstract: The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 9, 2004
    Inventors: Kenji Fujii, Taizo Kawabe, Kanunori Hosoe, Takayoshi Hidaka
  • Patent number: 6811772
    Abstract: Applicant's invention includes an improved bee attracting composition. Applicant's invention further includes a bee attracting device formed from his improved bee attracting composition. Applicant's bee attracting device can be further coated with a second bee attracting composition. Applicant's invention further includes a method and apparatus for attracting and immobilizing bees using a substrate coated with an adhesive composition upon which Applicant's bee attracting composition is disposed.
    Type: Grant
    Filed: January 6, 2003
    Date of Patent: November 2, 2004
    Inventor: Steven C. Thoenes