Plural Oxygens Patents (Class 514/718)
  • Publication number: 20030004134
    Abstract: A method of potentiating the activity of a drug which affects the central nervous system. (CNS) comprising systemically administrating to a subject said drug together with an effective amount of a compound which affects peripheral chemoreceptors and, optionally, with an effective amount of a stimulator of osmoreceptors. Also disclosed are pharmaceutical compositions for systemic administration comprising a CNS drug together with the aforementioned compounds.
    Type: Application
    Filed: February 5, 2001
    Publication date: January 2, 2003
    Inventor: Sergey Serdyuk
  • Patent number: 6500416
    Abstract: There are described a flowable composition for controlling harmful insects and representatives of the order Acarina, comprising at least one pesticidally active compound, one or more signal substances selected from the group consisting of pheromones, kairomones and attractants, a UV absorber or a UV absorber mixture and, if appropriate, one or more additives selected from the group consisting of viscosity-regulating thickeners, fillers, solvents and other formulation auxiliaries, which composition comprises 40 to 98% by weight of the UV absorber or the UV absorber mixture, 0.01 to 30% by weight of one or more signal substance(s) and 0.1 to 20% by weight of one or more pesticidally active compound(s) of the formulae (I) to (V) as specified, and a method of controlling harmful insects and representatives of the order Acarina using this composition.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: December 31, 2002
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Dieter Hofer, Max Angst, Pierre-Joseph Charmillot
  • Publication number: 20020198265
    Abstract: This invention provides a spermicidally and virucidally effective, vaginally applicable formulation, having the following approximate composition of essential ingredients:
    Type: Application
    Filed: July 29, 2002
    Publication date: December 26, 2002
    Applicant: GEDA International Marketing Company Ltd.
    Inventors: George M. Livingston, David B. Thornburgh, Jeffrey Longmore
  • Patent number: 6476076
    Abstract: The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: November 5, 2002
    Assignees: Pacific Corporation, Digital Biotech Co., Ltd.
    Inventors: Jeewoo Lee, Uhtaek Oh, Young-Ho Park, Young-Ger Suh, Hyeung-Geun Park, Hee-Doo Kim
  • Patent number: 6476069
    Abstract: A composition useful as an embolic agent that selectively creates an embolic blockage in the lumen of a blood vessel, duct, fistula or other like body passageways by combining a monomer component and a second component wherein, said monomer component comprises of a alkyl cyanoacrylate monomer and at least one inhibitor agent; and said second component that functions as an opacificant agent and a polymerization retardant.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: November 5, 2002
    Assignee: Provasis Therapeutics Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6476070
    Abstract: A composition comprising of a monomer component comprised of at least one alkyl cyanoacrylate and at least one inhibitor, and a second component comprised of a resultant aggregate structure formed from an alkyl cyanoacrylate monomer, an alkyl esterified fatty acid and an opacificant agent where said composition forms a resultant aggregate structure when said composition contacts an anionic environment. The compositions are useful for filling, occluding, partially filling or partially occluding an unfilled volume or space in a mass in an anionic environment. The composition are also useful for ablating diseased or undesired tissue by cutting off the blood supply to the tissue.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: November 5, 2002
    Assignee: Provasis Therapeutics Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6462091
    Abstract: The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include an HMG CoA reductase inhibitor combined with a cholesteryl ester transfer protein (CETP) inhibitor.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: October 8, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Bradley T. Keller, James A. Sikorski, Kevin C. Glenn, Daniel T. Connolly, Mark E. Smith
  • Patent number: 6458851
    Abstract: The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include an ileal bile acid transport inhibitor combined with a cholesteryl ester transfer protein (CETP) inhibitor.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: October 1, 2002
    Assignee: G. D. Searle, LLC
    Inventors: Bradley T. Keller, James A. Sikorski, Kevin C. Glenn, Daniel T. Connolly, Mark E. Smith, Joseph R. Schuh
  • Patent number: 6458850
    Abstract: The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include a fibric acid derivative combined with a cholesteryl ester transfer protein (CETP) inhibitor.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: October 1, 2002
    Assignee: G.D. Searle, LLC
    Inventors: James A. Sikorski, Kevin C. Glenn
  • Patent number: 6451844
    Abstract: The use of menthyl 2-pyrrolidone-5-carboxylate as an insect repellent, usually by application to a substrate or into an air space. The menthyl 2-pyrrolidone-5-arboxylate can be used as a composition, which may be perfumed. A useful composition comprises a mixture of menthyl 2-pyrrolidone-5-arboxylate and a known insect repellent or a compound shown to be an effective insect repellent on a test described herein.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: September 17, 2002
    Assignee: Quest International BV
    Inventors: Stephen D Watkins, Maxine J Hills, Richard A Birch
  • Publication number: 20020128323
    Abstract: Antimicrobial compounds, compositions containing the same, and methods of using of the same for reducing the presence of microorganisms on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated phenoxy and/or benzyloxy substituted phenol compounds.
    Type: Application
    Filed: December 20, 2001
    Publication date: September 12, 2002
    Inventors: David Scott Harper, Robert A. Coburn, Constantine Georgiades, Andre Soshinsky, Marianne D. Huntley
  • Patent number: 6444230
    Abstract: Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid, c) from 0.001% to 35% by weight of hydrogen peroxide, d) from 0.0001% to 2% by weight of at least one compound of formula (I) (R1)(R2)(R3)N→O  (I) e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and wherein f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: September 3, 2002
    Assignees: Chemoxal SA, Societe d'Exploitation de Produits pour les Industries Chimiques Seppic
    Inventors: Catherine Hamon Godin, Yves Gouges, Daniel Le Rouzic
  • Patent number: 6444709
    Abstract: The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: September 3, 2002
    Assignee: Galderma Research & Development S.N.C.
    Inventors: Philippe Diaz, Jean-Michel Bernardon
  • Patent number: 6440406
    Abstract: The present invention provides a composition for attracting scarabs. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating scarabs, and/or protecting plants susceptible to scarab damage.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 27, 2002
    Assignees: The United States of America as represented by the Secretary of Agriculture, The Texas A&M University System
    Inventors: Juan D. Lopez, Jr., Robert L. Crocker, Ted N. Shaver
  • Patent number: 6441050
    Abstract: The present invention relates to a composition in pharmaceutical dosage form of coenzyme Q or ubiquinol which can be administered to children in an oral dosage form as a pleasant-tasting liquid. The dosage form comprises an effective amount of coenzyme Q or ubiquinol ranging from about 0.05% to about 10%, more preferably about 1% to about 7.5% by weight of the composition in combination with a minor amount of a polysorbate surfactant such as a Tween™ surfactant, most preferably, polysorbate 80, a major amount of a vegetable oil or triglyceride, in further combination with an amount of phospholipid such as hydroxylated lecithin effective to maintain ubiquinone/ubiquionol in hydrosoluble form and to substantially enhance the palatability of ubiquinone or ubiquinol in combination with a sweetener solution as well as an amount of water preferably ranging from about 5% to about 45% by weight.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: August 27, 2002
    Inventor: Raj K. Chopra
  • Patent number: 6436448
    Abstract: A novel method for preventing and treating lymphedema and for inducing weight-loss in a patient having an elevated protein concentration in the patient's by administering a therapeutically effective amount of guaifenesin or its analog to the patient. In one embodiment, the method further includes administering in the patient's diet an enzyme supplement chosen to increase the ability of the patient's gastrointestinal tract to digest food and administering to the patient an effective amount of relaxin hormone.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: August 20, 2002
    Assignee: Sky BioHealth Solutions, Inc.
    Inventor: Samuel K. Yue
  • Publication number: 20020107287
    Abstract: A pesticide for cockroaches and larvae which is based on purified naturally occurring plant substances. Phenethyl propionate; methyl salicylate; pulegone; carvacrol; thymol; thyme oil; citronellal; a three-blend of eugenol, &agr;-terpineol and cinnamic alcohol; a four-blend of benzyl alcohol, phenethyl alcohol, phenethyl propionate and &agr;-terpineol; and a five-blend of thymol, t-anethole, &agr;-terpineol, eugenol and citronellal have been used as the pesticide. The pesticide affects the octopamine receptor site in the cockroach. The five-blend has been used as a pesticide for Asian armyworms and green peach aphid nymphs. Methods of use of the pesticides are disclosed.
    Type: Application
    Filed: December 17, 2001
    Publication date: August 8, 2002
    Inventors: Steven M. Bessette, Myron A. Beigler
  • Patent number: 6410596
    Abstract: The use of isolated or purified stilbenoid compounds including longistyline A-2-carboxylic acid as hypoglycemic agents or to lower serum glucose levels is described. The invention also relates to the use of such stibenoid compounds in combination with other hypoglycemic agents.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: June 25, 2002
    Assignee: Insmed Incorporated
    Inventors: David C. Hopp, Wayne D. Inman
  • Publication number: 20020072538
    Abstract: The invention provides new methods for treating certain disorders resulting from neurodegeneration and for treating depression which comprise administration of NR2B subunit selective NMDA antagonists. The disorders that can be treating by the invention include hearing loss, vision loss, neurodegeneration caused by epileptic seizures, neurotoxin poisoning, Restless Leg Syndrome, multi-system atrophy, non-vascular headache, and depression.
    Type: Application
    Filed: October 2, 2001
    Publication date: June 13, 2002
    Inventors: Bertrand L. Chenard, Frank S. Menniti, Mario D. Saltarelli
  • Publication number: 20020065310
    Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
    Type: Application
    Filed: May 9, 2001
    Publication date: May 30, 2002
    Inventors: Ru Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang
  • Publication number: 20020058698
    Abstract: The present invention is directed to the synthetic processes outlined in Schemes 1, 2 and 3, to the novel intermediates recited therein, and to the uses of these compounds as synthetic precursors to the pseudopterosins. Other embodiments and aspects of the present invention include the novel synthetic procedures described herein.
    Type: Application
    Filed: June 27, 2001
    Publication date: May 16, 2002
    Inventor: Elias J. Corey
  • Patent number: 6387955
    Abstract: The present invention discloses the use of permanently charged steroid agonists or antagonists as potent anti-angiogenic compositions comprising as an active ingredient a compound of the general formulae I, II or III: wherein DRUG is any steroid agonist or antagonist, a mixed agonist-antagonist, or a partial agonist and the substituents are as defined in the specification.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: May 14, 2002
    Assignee: Pharmos Corporation
    Inventors: Anat Biegon, Marcus E. Brewster
  • Patent number: 6384085
    Abstract: Disclosed are novel materials separated from Ecklonia cava, a method for extracting and purifying the same, and the use thereof for antioxidants. The method comprises extracting antioxidative ingredients from powdered Ecklonia cava one or more times with an organic solvent; fractionating the antioxidative ingredients one or more times in solvents; and purifying the solvent fractions by chromatography. Superior in scavenging activity and thermal stability, the extract from Ecklonia cava can be used as antioxidants and is suitable in commercialization.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: May 7, 2002
    Assignee: Ventree Co., Ltd.
    Inventors: Bong-Ho Lee, Byung-Wook Choi, Geon-Seek Ryu, Sang-Keun Kim, Hyeon-Cheol Shin
  • Publication number: 20020045656
    Abstract: This invention relates to methods of treating traumatic brain injury (TBI) or hypoxic or ischemic stroke, comprising administering to a patient in need of such treatment an NR2B subtype selective N-methyl-D-aspartate (NMDA) receptor antagonist in combination with either: (a) a neutrophil inhibitory factor (NIF); (b) a sodium channel antagonist; (c) a nitric oxide synthase (NOS) inhibitor; (d) a glycine site antagonist; (e) a potassium channel opener; (f) an AMPA/kainate receptor antagonist; (g) a calcium channel antagonist; (h) a GABA-A receptor modulator (e.g., a GABA-A receptor agonist); or (i) an antiinflammatory agent.
    Type: Application
    Filed: September 6, 2001
    Publication date: April 18, 2002
    Inventors: Bertrand L. Chenard, Frank S. Menniti, Mario D. Saltarelli
  • Patent number: 6369115
    Abstract: A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of fluticasone, in a dry powder form, and an excipient. A method for preparing a physically stable dry powder formulation for inhalation includes the steps of micronizing a first active polar drug, a second active non-polar drug, and a polar excipient. The second non-polar active drug is first blended with the excipient to form an intermediate mixture. The intermediate mixture is then blended with the first active polar drug. The increased separation of the polar drug and polar excipient stabilizes the formulation.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: April 9, 2002
    Assignee: Dura Pharmaceuticals, Inc.
    Inventor: Gary Ward
  • Publication number: 20020028229
    Abstract: The invention provides antimicrobial compositions which contain a phenol complex with a film forming complex of a polycarboxylic acid and a microbicide containing at least two quaternary amine groups.
    Type: Application
    Filed: January 25, 2000
    Publication date: March 7, 2002
    Inventors: John Lezdey, Jarett R. Lezdey
  • Publication number: 20020019405
    Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.
    Type: Application
    Filed: August 30, 2001
    Publication date: February 14, 2002
    Inventors: David S. Garvey, Inigo Saenz de Tejada, Richard A. Earl, Subhash P. Khanapure
  • Publication number: 20020013261
    Abstract: Novel methods and compositions for stimulating angiogenesis, particularly at regions of myocardial and peripheral tissue ischemia are disclosed. Angiogenesis is promoted or enhanced by contacting a polyethylene glycol (PEG) polymer, such as a PEG mono-, di-, tri-, or tetraacrylate containing a photoinitator (eosin Y) and a radical generator (triethanolamine) and a reaction accelerator (n-vinyl pyrrolidine), with an area of tissue ischemia. The PEG polymer can be applied alone or in conjunction with angiogenic proteins or genes encoding angiogenic proteins.
    Type: Application
    Filed: May 18, 2001
    Publication date: January 31, 2002
    Inventors: Robert Pawliuk, Philippe Leboulch
  • Patent number: 6342536
    Abstract: A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: January 29, 2002
    Assignee: Ecosmart Technologies Incorporated
    Inventors: Steven M. Bessette, Myron A. Beigler
  • Publication number: 20010036965
    Abstract: Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.
    Type: Application
    Filed: April 3, 2001
    Publication date: November 1, 2001
    Applicant: The Medical College of Hampton Roads, Eastern Virginia Medical School
    Inventors: George Digenis, Philip Fowler, Kazuya Matsumoto, Gustavo Doncel
  • Patent number: 6303654
    Abstract: A method of inhibiting or preventing the growth of tumor cells is disclosed. In one embodiment, this method comprises the step of administering a compound selected from the group consisting of citracetal, citral dimethyl acetal, citral diethyl acetal, geranyl benzoate, geranyl tiglate, geranyl anthranilate, farnesyl benzoate, farnesyl anthranilate, farnesyl tiglate, farnesyl acetate and combinations thereof to a human tumor patient, wherein the amount is effective to reduce or inhibit tumor growth by at least 50%.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: October 16, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Charles E. Elson, Huanbiao Mo
  • Patent number: 6288011
    Abstract: Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds having the structural formula I and compositions and methods comprising those compounds for the control of insect and acarid pests.
    Type: Grant
    Filed: November 11, 1998
    Date of Patent: September 11, 2001
    Assignee: American Cyanamid Co.
    Inventors: Terence James Bentley, Keith Douglas Barnes
  • Patent number: 6281251
    Abstract: Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: August 28, 2001
    Assignees: University of Kentucky Research Foundation, The Medical College of Hampton Roads, Eastern Virginia Medical School
    Inventors: George Digenis, Philip Fowler, Kazuya Matsumoto, Gustavo Doncel
  • Patent number: 6274570
    Abstract: A liquid pesticidal composition, which is substantially free of water, comprising a hydrophobic pesticide or mixture of pesticides dissolved in an organic solvent and comprising as surfactants (a) a castor oil ethoxylate having 30-50 mol ethoxylate, (b) a branched C8-C18 alcohol ethoxylate having 5-10 mol ethoxylate, and (c) a tristyrenephenol-ethoxylate having 8-30 mol ethoxylate, or its phosphate or salt thereof. The compositions also include gels having a viscosity of 500 to 20,000 mPas and comprising additionally a gelling agent.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: August 14, 2001
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Manfred Vogt, William Baettig
  • Patent number: 6267947
    Abstract: An improved long acting pesticide formulation is described. A water swellable polycarboxylated polymer is dissolved in a solution/suspension of a pesticide formulation in a substantially non-aqueous liquid carrier. The composition, upon topical application, dries to a surface adherent polymer matrix film that swells responsive to contact with water/ambient humidity to effect prolonged pesticidal efficacy.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: July 31, 2001
    Assignee: Sun Glitz Corporation
    Inventor: Nola Janene McVicker
  • Patent number: 6251942
    Abstract: Composition and methods of alleviating impaired mental function and memory loss in mammals and reducing the recovery time from anaesthesia in age mammals, comprising treating the mammal with a non-toxic, enhancing effective amount of a cell membrane permeant calcium buffer. The buffer is preferably a calcium ion chelating agent having a KD selected from the range 1×10−4 to 1×10−8 Molar and being essentially calcium ion-selective over other metal ions. A most preferred buffer is BAPTA-AM.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: June 26, 2001
    Inventors: Peter Louis Carlen, Christopher George Janus, Hossam El-Beheiry
  • Patent number: 6183767
    Abstract: A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.
    Type: Grant
    Filed: April 8, 1998
    Date of Patent: February 6, 2001
    Assignee: Ecosmart Technologies, Incorporated
    Inventors: Steven M. Bessette, Myron A. Beigler
  • Patent number: 6168808
    Abstract: Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid, c) from 0.001% to 35% by weight of hydrogen peroxide, d) from 0.0001% to 2% by weight of at least one compound of formula (I) (R1) (R2) (R3)N→O  (I) e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and wherein f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: January 2, 2001
    Assignees: Chemoxal SA, Societe d'Exploitation de Produits pour les Industries Chimiques Seppic
    Inventors: Catherine Hamon Godin, Yves Gouges, Daniel Le Rouzic
  • Patent number: 6166075
    Abstract: This invention relates to new antiestrogens of the general formula ##STR1## in which the substituents have the meanings that are explained in more detail in the description.The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens).Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: December 26, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Rolf Bohlmann, Karsten Parczyk, Karl-Heinrich Fritzemeier, Monika Lessl, Rosemarie Lichtner
  • Patent number: 6136865
    Abstract: A method for reduction of the viral infectiousness of potentially infectious material, such as human or animal body fluids or fractions derived therefrom from which biologically active substances can be isolated, wherein the infectiousness is due to non-lipid-coated viruses characterized in thatsaid potentially infectious material for the isolation of said biologically active substances is treated witha hydrophobic phase which is essentially insoluble in water and is capable of forming a two-phase system with said potentially infectious material, andsaid hydrophobic phase is separated from the potentially infectious material thus treated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 24, 2000
    Assignee: Octapharma AG
    Inventors: Lothar Biesert, Horst Schwinn, Wolfgang Marguerre
  • Patent number: 6080788
    Abstract: This invention provides a dietary supplement comprising L-Carnitine (or its functional analogues such as Acetyl-Carnitine or Proprionyl-l-Carnitine), Coenzyme Q10 and Taurine for the correction of the abnormality in mitochondrial energetics in cardiac failure and certain other diseases. A high protein nutritional feeding supplementation with Cysteine, Creatine, Vitamin E (RRR-d-alpha-tocopherol), Vitamin C (ascorbic acid), Selenium, and Thiamin in may be added.
    Type: Grant
    Filed: January 6, 1998
    Date of Patent: June 27, 2000
    Inventors: Michael J. Sole, Khursheed N. Jeejeebhoy
  • Patent number: 6028093
    Abstract: Fungicidal mixtures, comprisinga) a carbamate of the formula I ##STR1## where T is CH or N, n is 0, 1 or 2 and R is halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -haloalkyl, it being possible for the radicals R to be different when n is 2, and/orb) an oxime ether of the formula II, ##STR2## where the substituents have the following meanings: X is oxygen or amino;Y is CH or N;Z is oxygen, sulfur, amino or C.sub.1 -C.sub.4 -alkylaminoR' is C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -haloalkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.3 -C.sub.6 -haloalkynyl, C.sub.3 -C.sub.6 -cycloalkyl-methyl, or is benzyl which can be partially or fully halogenated and/or can have attached to it one to three of the following radicals: cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy and C.sub.1 -C.sub.4 -alkylthio; andc) a carbamate of the formula III(CH.sub.3).sub.2 N--CH.sub.2 CH.sub.2 CH.sub.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: February 22, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Muller, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann, Klaus Schelberger, Maria Scherer, Dietrich Mappes, Joachim Leyendecker, Herbert Bayer, Ruth Muller
  • Patent number: 5962461
    Abstract: A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a bitter tasting drug dissolved or dispersed in an aqueous medium that is free of ethanol. That aqueous medium consists essentially of water, about 5 to about 30 weight percent polyvinylpyrrolidone, about 35 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants. The liquid composition is transparent and has a pleasant taste. The bitter tasting drugs claimed herein are vitamin and mineral preparations, trimethoprim, and guaifenesin.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: October 5, 1999
    Assignee: Ascent Pediatrics, Inc.
    Inventors: Aloysius O. Anaebonam, Emmett Clemente, Abdel A. Fawzy
  • Patent number: 5958946
    Abstract: Mammalian hair growth may be modulated by applying to the skin a compound that induces or activates the conjugation of an androgen.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: September 28, 1999
    Inventors: Peter Styczynski, Gurpreet S. Ahluwalia
  • Patent number: 5936120
    Abstract: The invention provides deoxygossylic compounds having useful biological activities, and methods for the synthesis of these and related compounds. The invention further provides valuable intermediates for the synthesis of the compounds, and pharmaceutical compositions containing biologically active compounds according to the invention.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: August 10, 1999
    Assignee: University of New Mexico
    Inventors: Robert D. Royer, Lorraine M. Deck, David L. VanderJagt
  • Patent number: 5880146
    Abstract: Disclosed are chemical agents for modulating certain cellular immune reactions that can lead to autoimmune disorders. By specific modulation, harmful immune reactions can be lessened in severity or even prevented without resorting to potentially dangerous general immune suppression. The described chemical agents inhibit IL-12 induction of the secretion of key immune modulators. The described chemical agents are specific inhibitors of IL-12 induced Th1 immune response.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 9, 1999
    Assignee: Fuji ImmunoPharmaceuticals Corporation
    Inventors: Stephen D. Gillies, John Wesolowski
  • Patent number: 5880162
    Abstract: A pesticidal compound of formula I: ##STR1## in which formula: either R.sup.1 is hydrogen and R.sup.2 represents a cyclopropyl group or R.sup.1 and R.sup.2 each represent an alkyl group, which alkyl groups may be the same or different;Ar.sub.A represents an optionally substituted phenyl or naphthyl group;Ar.sub.B represents a phenoxy, phenyl, benzyl or benzoyl-substituted phenyl group which is optionally further substituted;the configuration of the groups Ar.sub.A --CR.sup.1 R.sup.2 and --CH.sub.2 Ar.sub.B about the double bond being mutually trans.Preferably Ar.sub.A is a substituted phenyl group; more preferably being substituted at the 4-(para) position by halogen, alkoxy or haloalkyl.Further provided is a process for the preparation of a pesticidal compound of formula I in which a compound comprising a moiety ##STR2## and a compound comprising a moiety Ar.sub.B -- are reacted together forming a link --CH.dbd.C(F)CH.sub.2 -- between ##STR3## and Ar.sub.B in the compound of formula I.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: March 9, 1999
    Assignee: British Technology Group, Ltd.
    Inventors: Bhupinder Pall Singh Khambay, Mu-Guang Liu
  • Patent number: 5874478
    Abstract: This invention relates to compounds, compositions, uses and methods for inhibiting viral and retroviral replication and for treating viral and retroviral infections via the administration of various compounds, including antioxidants, preferably compounds corresponding to the formula ##STR1## wherein n=1, 2, 3, or 4; m=0 or 1; X is O, S or CH.sub.2 ; R.sub.1 is hydrogen or tertiary butyl or lower alkyl of from one to six carbon atoms, inclusive; R.sub.2 is tertiary butyl or lower alkyl of from one to six carbon atoms, inclusive; and R.sub.3 is hydrogen or alkyl or aryl or mixed alkyl/aryl, containing a total of 5-25 carbon atoms.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: February 23, 1999
    Assignee: Vyrex Corporation
    Inventors: Sheldon Saul Hendler, Robert A. Sanchez, Tara
  • Patent number: 5874460
    Abstract: Compounds of the formula ##STR1## where W is (CH.sub.2).sub.n where n is 1 or 2, or n is 0 and W represents lower alkyl groups attached to each oxygen;m is an integer between 1 and 8;R.sub.1 is COOH or a pharmaceutically acceptable salt thereof, COOR.sub.4, CONR.sub.5 R.sub.6, CONR.sub.5 SO.sub.2 R.sub.7, CH.sub.2 OH, CH.sub.2 OR.sub.7, CH.sub.2 O--COR.sub.7, CH.sub.2 O--CONR.sub.5,R.sub.7, CH.sub.2 OCOOR.sub.7, CH.sub.2 NH.sub.2, CH.sub.2 NR.sub.5 R.sub.6, etc. where R.sub.4 is an alkyl group, or a cycloalkyl group, or R.sub.4 is phenyl or lower alkylphenyl, R.sub.5 and R.sub.6 independently are hydrogen, an alkyl group, etc., R.sub.7 is alkyl of 1 to 10 carbons, phenyl or lower alkylphenyl, R.sub.8 is lower alkyl, and R.sub.9 is divalent alkyl radical of 2-5 carbons, R.sub.10 is an alkyl OR cycloalkyl containing 1 to 5 carbons;R.sub.2 is H, COR.sub.7, R.sub.7, CO--OR.sub.7, CO--NR.sub.5,R.sub.7, PO(OH)OR.sub.7, PO(OR.sub.7).sub.2, POR.sub.7 OH, or POR.sub.7 (OR.sub.7) ;R.sub.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: February 23, 1999
    Assignee: Allergan Sales Inc.
    Inventors: Robert M. Burk, David F. Woodward
  • Patent number: RE36139
    Abstract: Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carton atoms, and/or a salt thereof.
    Type: Grant
    Filed: December 13, 1995
    Date of Patent: March 9, 1999
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro