Substituent Nitrogen Bonded Directly To Carbon Of The Triazine Ring Patents (Class 544/194)
  • Patent number: 5968482
    Abstract: The invention relates to the use of .alpha.-hydroxyketoalkyl derivatives as light protection filters for cosmetic or pharmaceutical products, the .alpha.-hydroxyketoalkyl group being linked, if appropriate via a spacer, to a chromophoric group which has an absorption maximum in a wavelength range of between 280 and 400 nm and has a conjugated .pi.-electron system of at least 8 .pi.-electrons, and to new .alpha.-hydroxyalkyl derivatives, processes for their preparation and pharmaceutical and cosmetic formulations comprising these derivatives as light protection substances.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: October 19, 1999
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Roland Martin, Ingeborg Stein, Ulrich Heywang, Michael Schwarz, Thekla Kurz
  • Patent number: 5969140
    Abstract: Naphthalene derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each H, protected or unprotected OH, one of R.sup.3 and R.sup.4 is protected or unprotected hydroxymethyl, and the other is H, lower alkyl, or protected or unprotected hydroxymethyl, R.sup.5 and R.sup.6 are the same or different and are each H, substituted or unsubstituted lower alkyl, substituted or unsubstituted phenyl or protected or unprotected NH.sub.2, or both combine together with the adjacent N to form substituted or unsubstituted heterocyclic group, and pharmaceutically acceptable salts thereof, these compounds showing excellent bronchoconstriction inhibitory activity, and hence, being useful in the prophylaxis or treatment of asthma.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: October 19, 1999
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tatsuzo Ukita, Katsuo Ikezawa, Shinsuke Yamagata
  • Patent number: 5968208
    Abstract: A process for coloration of a substrate comprising applying thereto at a pH above 7 a water-soluble reactive dye comprising at least three chromophoric groups linked to a polyamine. Also claimed are dyes suitable for use in the process.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: October 19, 1999
    Assignee: Zeneca Limited
    Inventor: John Anthony Taylor
  • Patent number: 5962453
    Abstract: The invention relates to a medicinal composition comprising a triazine derivative of the following general formula ?I! ##STR1## or a solvate thereof, or a salt thereof, as an active ingredient. In the above formula, R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, unsubstituted or substituted alkyl aralkyl, or alkenyl, or jointly represent cyclic amino (NR.sup.1 R.sup.2) in combination with the adjacent nitrogen atom. The cyclic amino may contain nitrogen, oxygen, or sulfur as a ring member in addition to the adjacent nitrogen and may be further substituted. Excluded is the case in which NR.sup.1 R.sup.2 is NH.sub.2. The compound of the invention is useful as a therapeutic drug for hepatitis.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: October 5, 1999
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Fusao Ueda, Takayuki Ozaki, Ken-ichi Nakamura
  • Patent number: 5958933
    Abstract: A method for treating a mammal having a damaged central nervous system, as the result of trauma or disease, for reestablishing previously destroyed neurological functions in a traumatized or diseased mammal, or for controlling spasticity and for providing protection from such injury to the central nervous system. The method comprises administering to the mammal at least one neurologically active compound comprising two groups, one group providing alpha-adrenergic agonist activity, specifically a guanidino group, and the second group providing agonist activity selected from the group consisting of beta-adrenergic agonist activity, serotinergic agonist activity, and GABA-ergic agonist activity (for example a methylated xanthine group, having beta-adrenergic agonist activity) as the primary therapeutic agent. The neurologically active compound is administered in a dosage amount and at a dosage rate sufficient to at least partially restore the lost neurological function or to control spasticity.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 28, 1999
    Inventor: N. Eric Naftchi
  • Patent number: 5945396
    Abstract: The present invention provides a compound having the formula: ##STR1## in which each R.sub.d is the same or different and each is --NH--Z--N(R.sub.a)(R.sub.b) or --N--?Z--N(R.sub.a)(R.sub.b)!.sub.2 in which Z is C.sub.2 -C.sub.14 alkylene or optionally substituted arylene, R.sub.a and R.sub.b are the same or different and each is C.sub.1 -C.sub.12 alkyl, or R.sub.a and R.sub.b, together with the nitrogen atom to which they are each attached, form a morpholino, piperidino or piperazino ring; each R.sub.c is the same or different and is NH.sub.2, NH(C.sub.1 -C.sub.4 alkyl), N(C.sub.1 -C.sub.4 alkyl).sub.2, N(CH.sub.2 CH.sub.2 OH).sub.2, O--C.sub.1 -C.sub.4 alkyl, ##STR2## alkali metal atom, ammonium or a cation formed from an amine; or a quaternized form thereof.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: August 31, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Claude Eckhardt, Georges Metzger, Dieter Reinehr, Hanspeter Sauter, Mario Dubini
  • Patent number: 5942509
    Abstract: Fungicidal compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CA wherein A is H, halogen, C.sub.1-4 alkyl, cyano, nitro or trifluoromethyl; X is a linking group other than oxygen; T is oxygen or sulphur; and Z is an optionally substituted carbocyclic or heterocyclic ring.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: August 24, 1999
    Assignee: Zeneca Limited
    Inventors: John Martin Clough, Christopher Richard Ayles Godfrey, Paul John De Fraine, Ian Thomas Streeting, Gordon Richard Munns
  • Patent number: 5935954
    Abstract: The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: August 10, 1999
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David M. Armistead, Jeffrey O. Saunders
  • Patent number: 5922122
    Abstract: A composition containing an organic pigment and a compound having the formula (I): ##STR1## in which R.sup.1 is a group having the formula (II): ##STR2## in which R.sup.4 and R.sup.5 represent hydrogen or alkyl, or R.sup.4 and R.sup.5 are bonded to each other to form a ring together with a nitrogen atom, X represents alkylene or alkyleneoxyalkylene, and Y represents --O--, --S-- or a group represented by --NR.sup.6 -- wherein R.sup.6 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 represent a group having the formula (II), alkyl, aralkyl, aryl, alkoxy, aralkyloxy, aryloxy, alkylamino, arylamino or a halogen atom. A photosensitive colored composition is made of the composition, a polymer having acidic group, a photopolymerizable monomer and a photopolymerization initiator.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 13, 1999
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Akihiko Takeda, Takekatsu Sugiyama
  • Patent number: 5874576
    Abstract: A light screening agent, which contains a compound of the general formula ##STR1## wherein R and R' are alkyl, hydroxyalkyl, alkenyl, alkynyl, or alkyl ether radicals substituted by one or more hydroxy and/or alkoxy groups andAr represents one of the residues ##STR2## in which R.sup.2 is hydroxy, alkyl, alkenyl, alkynyl, or an alkyl, alkenyl, alkynyl ether residue or polyalkyl ether residue optionally substituted by one or more hydroxy and/or alkoxy groups and R.sup.3 is hydrogen or signifies a residue R.sup.2 and in which the hydroxy group is present in the .alpha.-position to the bonding to the triazine nucleus, with the number of C and O atoms present in R and R' being a total of 8 to 42, especially 8 to 18, and the number of O atoms corresponding to at most half of the C atoms.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: February 23, 1999
    Assignee: Givaudan-Roure (International) SA
    Inventor: Ulrich Huber
  • Patent number: 5872252
    Abstract: A process for compressing ethylenically unsaturated monomers at a pressure of 200-5000 bar in the absence of a polymerization initiator comprises carrying out compression in the presence of a sterically hindered amine derivative.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: February 16, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Heinz Friedrich Sutoris, Alexander Aumuller, Andreas Koch, Andreas Deckers, Eckard Schauss, Roger Klimesch, Arend Jouke Kingma, Wilhelm Weber
  • Patent number: 5807929
    Abstract: At least bis-imido 1,3,5-triazines and processes of preparing the same are disclosed. Also disclosed are prepolymers having at least bis-imido functionality and curable compositions comprising at least bis-imido 1,3,5-triazines or prepolymers thereof in combination with active hydrogen and/or epoxy functional materials. The at least bis-imido 1,3,5-triazines and prepolymers may be advantageously employed as crosslinking agents which crosslink by a ring opening reaction that eliminates the release of volatile organic compounds.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 15, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Lon-Tang Wilson Lin, Robert G. Lees, William F. Jacobs, III, Subban Ramesh
  • Patent number: 5804583
    Abstract: Derivatives of bicyclic heterocycles comprising a pyrimidone ring fused to another 5, 6, or 7 membered nitrogen heterocycle which is C-substituted, through a methylene bridge, by a biphenyl group.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: September 8, 1998
    Assignee: Istituto Luso Farmaco D'Italia
    Inventors: Aldo Salimbeni, Davide Poma, Anna Renzetti, Carlo Scolastico
  • Patent number: 5792864
    Abstract: The present invention relates generally to carboxylated amino-1,3,5-triazines and the preparation thereof via carboxylation of amino-1,3,5-triazines with carbon dioxide and a base. These carboxylated amino-1,3,5-triazines find use, for example, as intermediates in the production of other useful amino-1,3,5-triazine derivatives, and particularly carbamate and isocyanate functional 1,3,5-triazines. The present invention also relates to the preparation of such carbamate and isocyanate functional 1,3,5-triazines.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: August 11, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence Allen Flood, Ram Baboo Gupta
  • Patent number: 5792865
    Abstract: The present invention relates generally to carboxylated amino-1,3,5-triazines and the preparation thereof via carboxylation of amino-1,3,5-triazines with carbon dioxide and a base. These carboxylated amino-1,3,5-triazines find use, for example, as intermediates in the production of other useful amino-1,3,5-triazine derivatives, and particularly carbamate and isocyanate functional 1,3,5-triazines. The present invention also relates to the preparation of such carbamate and isocyanate functional 1,3,5-triazines.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: August 11, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence Allen Flood, Ram Baboo Gupta
  • Patent number: 5760227
    Abstract: The compounds of the s-triazine series of formula I ##STR1## wherein the symbols R.sub.1, R.sub.2, R.sub.3, X and n possess the significances given in claim 1, are eminently suitable, when applied to textile material, as UV-absorbers, as resist agents for anionic dyes, and as stain blockers.
    Type: Grant
    Filed: July 31, 1996
    Date of Patent: June 2, 1998
    Assignee: Clariant Finance (BVI) Limited
    Inventor: Jean-Luc Mura
  • Patent number: 5741905
    Abstract: New compounds having the formula ##STR1## in which m is 1 or 2; when m is 1, A is a residue selected from those of the formulae ##STR2## and, when m is 2, A is a residue of the formula ##STR3## B is --O--, --NH-- or --SO.sub.2 --, and D is as defined herein, are useful as ultraviolet absorbing agents (UVAs) and a method of improving the sun protection factor of textile fibre material by treating the material with the new compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 21, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Jean-Pierre Bacher, Werner Kaufmann, Dieter Reinehr
  • Patent number: 5739328
    Abstract: A process for preparing asymmetrically substituted triazines of the formula I ##STR1## where R.sup.1 is hydrogen, methyl or ethyl, R.sup.2 and R.sup.3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II ##STR2## with a carboxylic acid derivative in the presence of an alcohol of the formula IIIR.sup.2 --OH III,which comprises reacting a carboxylic acid ester of the formula IVR.sup.3 --COOR.sup.4 IV,where R.sup.3 has the abovementioned meaning and R.sup.4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: April 14, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Schafer, Horst Mayer
  • Patent number: 5712391
    Abstract: Disclosed are amino silicone derivatives having triazinyl groups or pyrimidinyl groups bound to amino groups of amino silicones, their production and use, said silicone derivatives being able to gel silicone oil or to increase the viscosity thereof stably and homogeneously, and therefore being useful as bases for cosmetics, pharmaceutical preparations and industrial materials.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: January 27, 1998
    Assignee: Chiba Flour Milling Co., Ltd.
    Inventors: Hiroyuki Ohno, Natsue Kawahara, Isaburo Amano, Takanao Suzuki, Koji Chiba
  • Patent number: 5703235
    Abstract: Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; orR.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.10 is hydrogen or C.sub.1 -C.sub.
    Type: Grant
    Filed: March 21, 1996
    Date of Patent: December 30, 1997
    Assignee: Neurogen Corporation
    Inventors: Jun Yuan, Xi Chen
  • Patent number: 5700295
    Abstract: The invention relates to compounds of formula ##STR1## wherein the variables have the meanings given in the claims. The compounds are suitable for use as UV absorbers for the photochemical stabilisation of undyed, dyed or printed textile fiber materials and for enhancing the sun protection factor thereof.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: December 23, 1997
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Francesco Fuso, Gerhard Reinert
  • Patent number: 5696261
    Abstract: Novel piperidine-triazine compounds of the formula (Ia) and (Ib) suitable for use as light stabilisers, heat stabilisers and oxidation stabilisers for organic materials. The meanings of R.sub.1, R.sub.2, R.sub.3, G.sub.1, G.sub.2, L.sub.1, L.sub.2, m and n are defined in the text.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: December 9, 1997
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Valerio Borzatta, Graziano Vignali, Fabrizio Guizzardi
  • Patent number: 5677450
    Abstract: Disclosed are an organic acid salt of melamine represented by the following general formula (1) and a thermosetting and a photocurable and thermosetting coating compositions containing the salt mentioned above. ##STR1## wherein Z represents ##STR2## wherein R.sup.1 represents a hydrogen atom or an alkyl group, alkylene group, alicyclic hydrocarbon, or aromatic hydrocarbon severally having from 1 to 18 carbon atoms, or any of said groups or hydrocarbons whose hydrogen atom is substituted by carboxyl group, hydroxyl group, or a halogen atom, R.sup.2 represents a hydrogen atom or an alkyl group or alkylene group severally having from 1 to 9 carbon atoms, or any of said groups whose hydrogen atom is substituted by acryloyl group or methacryloyl group, R.sup.3 represents an alkyl group or alkylene group severally having from 1 to 9 carbon atoms, or any of said groups whose hydrogen atom is substituted by acryloyl group or methacryloyl group, and R.sup.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: October 14, 1997
    Assignee: Taiyo Ink Manufacturing Co., Ltd.
    Inventors: Nobuyuki Suzuki, Kazunobu Fukushima, Kyo Ichikawa, Teruo Saito, Hitoshi Inagaki
  • Patent number: 5672703
    Abstract: New classes of 1,3,5-triazine compounds and compositions containing the same are disclosed, which compounds are of the general formula ##STR1## wherein each of Y, Z and optionally X are independently selected from a group of the formula (II), (III) and/or (IV) ##STR2## These compounds and compositions are particularly suitable for use as crosslinking agents in curable compositions such as coatings, particularly in combination with active hydrogen groups-containing materials. The 1,3,5-triazine compounds of the present invention do not release formaldehyde as a volatile by-product during cure, and certain of these compounds may be used in curable compositions which may be cured at relatively low temperature. Processes for preparing such compounds, compositions containing the same, as well as additional uses thereof, are also disclosed.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: September 30, 1997
    Assignee: Cytec Technology Corp.
    Inventors: Subban Ramesh, Laurence Lyman Williams, Ram Baboo Gupta, Lon-Tang Wilson Lin
  • Patent number: 5659041
    Abstract: Radionuclide chelating compounds are provided for conjugation to targeting molecules such as proteins, peptides or antibodies. The resulting labeled targeting molecules may be used in diagnosis and therapy.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: August 19, 1997
    Assignee: Resolution Pharmaceuticals, Inc.
    Inventors: Alfred Pollak, Robert A. Kirby, Robert Dunn-Dufault
  • Patent number: 5641885
    Abstract: The present invention relates to carboxylated amino-1,3,5-triazines represented by the formula: ##STR1## wherein Z and Z.sup.1 are independently selected from the group consisting of hydrogen, a hydrocarbyl, a hydrocarbyloxy and a group represented by the formula --N(Q).sub.2 ; each Q is independently selected from the group consisting of hydrogen, a hydrocarbyl and a group Y, with the proviso that no more than one Q in each --N(Q.sub.2) is Y; and Y is selected from the group consisting of a carboxyl group and a carboxylate salt group. These carboxylated amino-1,3,5-triazines find use, for example, as intermediates in the production of other useful amino-1,3,5-triazine derivatives, particularly carbamate and isocyanate functional 1,3,5-triazines. The so-produced derivatives may find use as, for example, crosslinking agents in curable compositions.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: June 24, 1997
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence Allen Flood, Ram Baboo Gupta
  • Patent number: 5637704
    Abstract: A process for the preparation hydroxyoxaalkylmelamines of the general formula I ##STR1## in which R.sup.1 denotes a residue of the general formula II ##STR2## in which the radicals R' can be the same or different and stand for hydrogen or C.sub.1 -C.sub.4 alkyl and n denotes 2 or 3 and the radicals R.sup.2 and R.sup.3 stand for one of the radicals R.sup.1 or hydrogen, by the reaction of melamine with a compound of the general formula III ##STR3## in which R' and n have the meanings stated above, at a temperature of from 120.degree. to 250.degree. C. and in the presence of an acid catalyst, in which the acid catalyst is used in a concentration of from 0.01 to 0.15 mol and preferably from 0.02 to 0.12 mol and more preferably from 0.03 to 0.1 mol, based on 1 mol of melamine.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: June 10, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Erhard Guenther, Wolfgang Reuther, Gunter Scherr, Manfred Dimmler
  • Patent number: 5624981
    Abstract: Polyalkylpiperidine-containing acetic acid and 3-aminoacrylic acid derivatives I ##STR1## where R.sup.1 is hydrogen, C.sub.1 - to C.sub.6 -alkyl, formyl, C.sub.2 - to C.sub.6 -alkanoyl, C.sub.1 - to C.sub.12 -alkoxy, C.sub.5 - to C.sub.6 -cycloalkoxy, cyanomethyl, hydroxymethyl, 2-hydroxyethyl or a radical of the formula --CR.sup.3 =CH--CO--OR.sup.4, whereR.sup.3 is hydrogen, C.sub.1 -to C.sub.6 -alkyl or a radical of the formula --CO--OR.sup.4 andR.sup.4 is C.sub.1 - to C.sub.20 -alkyl, C.sub.5 - to C.sub.8 -cycloalkyl, C.sub.7 - to C.sub.18 -aralkyl, phenyl, tolyl or a radical of the formula --(CH.sub.2 CH.sub.2 O).sub.n H or --[CH(CH.sub.3)CH.sub.2 O].sub.n H, where n is a number from 1 to 30,X is O, NH or NR.sup.6, whereR.sup.6 is C.sub.1 - to C.sub.12 -alkyl, andY is hydrogen or a group of the formula =CH--NHR.sup.7 or =CH--NR.sup.6 R.sup.7, whereR.sup.7 is phenyl which can be substituted by one to three C.sub.1 - to C.sub.12 -alkyl, C.sub.1 - to C.sub.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: April 29, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Martin Holderbaum, Alexander Aumueller, Hubert Trauth
  • Patent number: 5616708
    Abstract: Compounds of the following formula are provided: ##STR1## in which R.sup.1 represents a hydrogen atom or an optionally substituted alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, aryl or aralkyl group,A and B both represent a nitrogen atom, or represents a group CR.sup.5 and B represents a nitrogen atom or a group CR.sup.6 ;R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each independently represent a hydrogen or halogen atom, a hydroxy or cyano group or an optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, aralkyl, aryl, alkylamino, alkylthio or alkoxy group; andl represents an integer from 1 to 3.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: April 1, 1997
    Assignee: Shell Research Limited
    Inventor: Waldemar F. A. Pfrengle
  • Patent number: 5574037
    Abstract: This invention concerns novel compounds of the formula I: ##STR1## in which P is a group of formula II or a group of formula III; R.sup.1 is alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl; R.sup.2 is hydrogen, alkyl, amino or alkylamino; R.sup.3 and R.sup.4 are independently hydrogen, alkyl, phenyl or benzyl; R.sup.6 is alkyl, amino or alkylamino; C and D are independently ethylene or trimethylene; Z is a direct bond between C and D, or an oxy, thio, carbonyl, methylene, ethylenedioxymethylene, ethylidene, or isopropylidene link, or Z is a group of the formula .dbd.N.R.sup.5 in which R.sup.5 is alkyl, phenyl or benzyl; R8 is hydrogen, cycloalkylalkyl, alkyl, alkenyl, alkynyl or phenylalkyl; or R8 is a alkylene or alkenylene linked to the nitrogen atom of the group Q.A.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 12, 1996
    Assignee: Imperial Chemical Industries PLC
    Inventors: Stuart D. Mills, Rodney B. Hargreaves, Bernard J. McLoughlin
  • Patent number: 5554633
    Abstract: Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR.sup.9, where R.sup.9 is H or C.sub.1-6 alkyl; R.sup.1 represents H or C.sub.1-6 alkyl; R.sup.2 represents C.sub.1-6 alkyl substituted by CONR.sup.7 (CH.sub.2).sub.p R.sup.8 (where R.sup.7 is H or C.sub.1-6 alkyl, R.sup.8 is optionally substituted heteroaryl and p is 0, 1, 2, 3, 4, 5 or 6); R.sup.3 represents H, C.sub.1-6 alkyl or C.sub.2-6 alkynyl; R.sup.4 represents H, C.sub.1-6 alkyl or optionally substitute phenyl; R.sup.5 represents optionally substituted phenyl; R.sup.6 is H or C.sub.1-6 alkyl; and q is 0, 1, 2 or 3; are tachykinin antagonists useful in therapy.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: September 10, 1996
    Assignee: Merck, Sharp & Dohme, Ltd.
    Inventor: Martin R. Teall
  • Patent number: 5538976
    Abstract: A substituted tertiary amino compound represented by general formula (I) or a pharmaceutically acceptable salt thereof. They have an aromatase inhibiting activity and are useful as a prophylactic and/or therapeutic agent for breast cancer, mastopathy, endometriosis, prostatic-hypertrophy, and so forth.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: July 23, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Minoru Okada, Toru Yoden, Eiji Kawaminami, Yoshiaki Shimada, Masafumi Kudou, Yasuo Isomura
  • Patent number: 5520906
    Abstract: Triazine compounds of the formula I ##STR1## wherein Y is NH or O,R.sup.1 in each case independently of one another are a radical of the formula II ##STR2## wherein Phe is a phenylene group which is unsubstituted or substituted by 1 to 4 alkyl or alkoxy groups having 1 to 10 C atoms andX is H or --SO.sub.3 H,andR.sup.2 and R.sup.3in each case independently of one another are a radical of the formula Y-R.sup.1,oralkoxy, alkylamino, arylamino or aryloxy having 1 to 10 C atoms. Also, cosmetic formulations, medicaments and pharmaceutical formulations containing the compounds, particularly as filters for solar rays.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: May 28, 1996
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Ingeborg Stein, Michael Casutt, Ulrich Heywang, Roland Martin, Michael Schwarz
  • Patent number: 5489683
    Abstract: Novel piperidine-triazine compounds of the formula (Ia) and (Ib) suitable for use as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials. The meanings of R.sub.1, R.sub.2, R.sub.3, G.sub.1, G.sub.2, L.sub.1, L.sub.2, m and n are defined in the text.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: February 6, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Valerio Borzatta, Graziano Vignali, Fabrizio Guizzardi
  • Patent number: 5482920
    Abstract: Pyrimidinyloxy- and triazinyloxy- and pyrimidinylthio- and triazinylthio-butyric acid derivatives of formula I ##STR1## wherein Q is ##STR2## A is hydroxy or a group ##STR3## and the other substituents are as described in patent claim 1, and salts of compounds of formula I, have herbicidal action and are suitable as active ingredients in weed control compositions.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: January 9, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Christoph Luthy
  • Patent number: 5468857
    Abstract: Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is a specified linking group; and A, B and E, which may be the same or different, are H, hydroxy, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.1-4 haloalkoxy, C.sub.1-4 alkylcarbonyl, C.sub.1-4 alkoxycarbonyl, phenoxy, nitro or cyano; except that when Z is unsubstituted phenyl and X and K are oxygen, A, B and E are not all hydrogen.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: November 21, 1995
    Assignee: Imperial Chemical Industries PLC
    Inventors: Alan J. Buckley, Michael G. Huchings, Ian Ferguson, Kevin Beautement, John M. Clough, Patrick J. Crowley, Christopher R. A. Godfrey, Paul J. deFraine, Vivienne M. Anthony, Stephen P. Heaney
  • Patent number: 5466803
    Abstract: Novel piperidine-triazine compounds of the formula (I) useful as light stabilizers, heat stabilizers and antioxidants for organic materials.The meanings of R.sub.1, R.sub.2, R.sub.3, R.sub.4, X.sub.1, X.sub.2, X.sub.3, Y.sub.1, Y.sub.2, M and N are defined in the text.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: November 14, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Valerio Borzatta, Graziano Vignali
  • Patent number: 5449776
    Abstract: Novel piperidine compounds of the formula (I) are suitable for use as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials.The definitions of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, A and n in the formula (I) are given in the text.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: September 12, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Graziano Vignali, Fabrizio Guizzardi, Graziano Zagnoni
  • Patent number: 5449777
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen, C.sub.1 -C.sub.24 alkyl, phenyl-substituted C.sub.1 -C.sub.4 alkyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted C.sub.5 -C.sub.8 cycloalkyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted phenyl, with the proviso that both substituents R.sub.1 and R.sub.2 are not simultaneously hydrogen,n is an integer from 3 to 8,R.sub.3 is C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.8 alkyl which is interrupted by --O--, --S-- or --NR.sub.4 --, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted C.sub.5 -C.sub.8 cycloalkyl, phenyl-substituted C.sub.1 -C.sub.4 alkyl, unsubstituted or C.sub.1 -C.sub.12 alkyl-substituted phenyl or a radical --(CH.sub.2).sub.m --COOR.sub.4 or ##STR2## R.sub.4 is C.sub.1 -C.sub.18 alkyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted C.sub.5 -C.sub.8 cycloalkyl, benzyl or phenyl,R.sub.5 is hydrogen, methyl, benzyl or a radical --OR.sub.7,m is 1 or 2,X is O, S, or NR.sub.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: September 12, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Rita Pitteloud
  • Patent number: 5446044
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: August 29, 1995
    Assignee: Warner-Lambert Company
    Inventors: Edgardo Laborde, Mel Schroeder
  • Patent number: 5433873
    Abstract: The invention relates to novel compounds of formula I ##STR1## n is 1 or 2,R and R.sup..cndot. are each independently of the other --OR.sub.1, --SR.sub.2 or --NR.sub.3 R.sub.4,R.sub.1 is hydrogen, C.sub.1 -C.sub.30 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl or naphthyl, phenyl- or naphthyl-substituted C.sub.1 -C.sub.18 alkyl or phenyl or naphthyl which are substituted by C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy or C.sub.1 -C.sub.12 hydroxyalkyl,R.sub.2 is C.sub.1 -C.sub.30 alkyl, phenyl or naphthyl, phenyl- or naphthyl-substituted C.sub.1 -C.sub.18 alkyl or phenyl or naphthyl which are substituted by C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy or C.sub.1 -C.sub.12 hydroxyalkyl, or is a radical of formula (CH.sub.2).sub.p --CO--OR.sub.5,p is 1 or 2,R.sub.3 and R.sub.4 have each independently of the other the meanings of R.sub.1, or --NR.sub.3 R.sub.4 is piperidyl, pyrrolidyl or azepyl, andR.sub.5 is hydrogen, C.sub.1 -C.sub.30 alkyl, C.sub.5 -C.sub.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: July 18, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Hugo Camenzind
  • Patent number: 5414084
    Abstract: Herbicidal sulfonylureas of the formula I, ##STR1## in which X is --O--, --O--NR.sup.2 -- or --SO.sub.2 --NR.sup.2 --, Y is --N-- or CH,R.sup.1 is (substituted) alkyl, (substituted) alkenyl or (substituted) alkynyl, or else, where X=O, (substituted) phenyl,R.sup.2 is H, alkyl, alkenyl, alkynyl or cycloalkyl,R.sup.3, R.sup.4 are H, (substituted) alkyl or (substituted) alkoxy, halogen, alkylthio, alkylamino or dialkylamino andR.sup.5, R.sup.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: May 9, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Lothar Willms, Stephen Lachhein, Gunter Schlegel, Heinz Kehne
  • Patent number: 5387682
    Abstract: Radiation-sensitive organo-halogen compounds having a photo-labile halomethyl-1,3,5-triazine moiety and at least one polymerizable moiety within one molecule. The compounds of this invention have at least one halomethyl substituent attached to a carbon atom of the triazine moiety and at least one polymerizable monomeric moiety attached to another atom of the triazine moiety. The compounds of this invention can be used to prepare polymers having 1,3,5-triazine substituents attached thereto. The compounds of this invention are good photoinitiators, and compositions containing them can be used in printing, duplicating, copying, and other imaging systems. The compounds of this invention are capable of stimulation by actinic radiation at a wavelength of about 250 to 900 nanometers to generate free radicals.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: February 7, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: James A. Bonham, Mithcell A. Rossman, Richard J. Grant
  • Patent number: 5364937
    Abstract: Compounds of the formula I or salts thereof, ##STR1## in which X is oxygen, --O--NR.sup.2 -- or --SO.sub.2 --NR.sup.2 --, and Y is N or CH,R.sup.1 is (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or (C.sub.2 -C.sub.6)alkynyl, which are in each case optionally substituted, or, in the case where X=oxygen, also (subst.) phenyl,R.sup.2 is H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or -alkynyl or (C.sub.3 -C.sub.6) cycloalkyl,R.sup.3 and R.sup.4 are H, (subst.) (C.sub.1 -C.sub.4)alkyl or (subst.) (C.sub.1 -C.sub.4)alkoxy or halogen, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylamino or di[(C.sub.1 -C.sub.4)alkyl]-amino,R.sup.5 is H or (C.sub.1 -C.sub.4)alkyl and R.sup.6 is hydrogen,may be prepared by reacting compounds of the formula II,R.sup.1 --X--R.sup.7 (II)with compounds of the formulae III, IV and VR.sup.8 --OCN (III)SO.sub.2 Cl.sub.2 (IV) ##STR2## where R.sup.7 and R.sup.8 are H, a quarternary ammonium ion or one equivalent of a metal cation.
    Type: Grant
    Filed: March 4, 1993
    Date of Patent: November 15, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Gunter Schlegel
  • Patent number: 5342939
    Abstract: Abstract of the Disclosure: 2-Amino-4-fluoroalkoxy-1,3,5-triazines of the formula I ##STR1## where R.sup. is hydrogen, alkyl, alkenyl, alkynyl; R.sup.2 is hydrogen, halogen, haloalkyl, trifluoromethoxy or chlorodifluoromethoxy and n is 0 or 1 are prepared as described.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: August 30, 1994
    Assignee: BASF Aktiengesellschaft
    Inventor: Gerhard Hamprecht
  • Patent number: 5332737
    Abstract: This invention concerns novel compounds of the formula I: ##STR1## in which P is a group of formula II or a group of formula III; R.sup.1 is alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl; R.sup.2 is hydrogen, alkyl, amino or alkylamino; R.sup.3 and R.sup.4 are independently hydrogen, alkyl, phenyl or benzyl; R.sup.6 is alkyl amino or alkylamino; C and D are independently ethylene or trimethylene; Z is a direct bond between C and D, or an oxy, thio, carbonyl, methylene, ethylenedioxymethylene, ethylidene, or isopropylidene link, or Z is a group of the formula .dbd.N.R.sup.5 in which R.sup.5 is alkyl, phenyl or benzyl; R8 is hydrogen, cycloalkylalkyl, alkyl, alkenyl, alkynyl or phenylalkyl; or R8 is a alkylene or alkenylene linked to the nitrogen atom of the group Q.A.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: July 26, 1994
    Assignee: Imperial Chemical Industries PLC
    Inventors: Stuart D. Mills, Rodney B. Hargreaves, Bernard J. McLoughlin
  • Patent number: 5324834
    Abstract: The present invention relates to novel co-oligomers containing recurring units of the formulae (Ia) and (Ib) ##STR1## which have a number average molecular weight of e.g. from 1,000 to 5,000 and a (Ia):(Ib) ratio of e.g. 1:1, and in which R.sub.1 and R.sub.5 are e.g. N-(2,2,6,6-tetramethyl-4-piperidyl)-n-butylamino, R.sub.2 is e.g. 2,2,6,6-tetramethyl-4-piperidyl, R.sub.3 is e.g. hexamethylene, R.sub.4 is e.g. hydrogen and X is e.g. a group ##STR2## These compounds are particularly suitable for stabilizing organic materials against light, heat and oxidation.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: June 28, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Valerio Borzatta, Primo Carrozza
  • Patent number: 5300647
    Abstract: Hindered amines based on various 2,2,6,6-tetraalkylated nitrogen-containing heterocyclic moieties wherein the hindered nitrogen atom on the ring is substituted with O-acyl, O-carbamoyl or O-carbonate substituents and the 4-position of the ring is substituted with a variety of groups, are effective as light stabilizers in diverse substrate systems.
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: April 5, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Roger F. Malherbe, Roland A. E. Winter, James P. Galbo
  • Patent number: 5290888
    Abstract: A process for stabilizing an ethylenically unsaturated monomer or oligomer from premature polymerization is disclosed whereby a stabilizing amount of an N-hydroxy substituted hindered amine is added to said polymerizable monomer or oligomer. The ethylenically unsaturated monomer or oligomer encompass vinyl monomers or oligomers bearing at least one polymerizable moiety. The N-hydroxy substituted hindered amine inhibits premature polymerization in the liquid and/or vapor phase.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: March 1, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Leslie R. Gatechair, James L. Hyun, Peter J. Schirmann
  • Patent number: 5283363
    Abstract: The invention relates to a new process for the preparation of (hetero)arylalk(en/in)ylamines of the formula (I) ##STR1## in which A represents ethane-1,2-diyl (ethylene, dimethylene, --CH.sub.2 --CH.sub.2 --) or represents ethene-1,2-diyl (ethenylene, vinylene, --CH.dbd.CH--) or represents ethine-1,2-diyl (ethinylene, --C.ident.C--),characterized in that(a) in the event that, in formula (I), A represents ethine-1,2-diyl, halogeno(hetero)aryl compounds of the general formula (II)Ar--X (II)are reacted with aminoalkinyl compounds of the general formula (III) ##STR2## and, if appropriate, (b) in the event that, in formula (I), A represents ethane-1,2-diyl or ethene-1,2-diyl, the new (hetero)aralkinylamines which are obtained by the process step described under (a), of the general formula (Ia), ##STR3## are reacted with a hydrogenating agent, if appropriate in the presence of a catalyst and if appropriate in the presence of a diluent, the definitions applying to Ar, R.sup.1, R.sup.
    Type: Grant
    Filed: January 16, 1992
    Date of Patent: February 1, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Dietmar Kuhnt, Thomas Himmler, Heinz Ziemann