Three Substituent Nitrogens Bonded Directly To The Three Carbons Of The Triazine Ring Patents (Class 544/196)
-
Patent number: 8198387Abstract: Provided is a proton-conducting compound which provides proton conductivity without humidification and is suitable for electrochemical device materials such as solid electrolytes for fuel cells and electrolytes for batteries. Provided also is a proton-conducting polymer. The proton-conducting compound is composed of a melamine compound salt obtained from a melamine compound represented by the following formula (1) and a Bronsted acid and the proton-conducting polymer is obtained by homopolymerizing or copolymerizing the melamine compound salt. In formula (1), R1, R2, R3, R4, and R5 each is independently an alkyl group, an aryl group, an alkenyl group, a heterocyclic group, or a hydrogen atom; at least one of them is a group other than hydrogen; R2 and R3 or R4 and R5 may join together to form a heterocyclic structure; and the alkyl group, the aryl group, the alkenyl group, or the heterocyclic group may have a substituent.Type: GrantFiled: October 30, 2007Date of Patent: June 12, 2012Assignee: Nippon Steel Chemical Co., Ltd.Inventors: Atsushi Kawada, Aya Tashiro
-
Patent number: 8163748Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.Type: GrantFiled: May 23, 2008Date of Patent: April 24, 2012Assignee: New York UniversityInventors: Neville Robert Kallenbach, Young-Tae Chang, Zhigang Liu, Chunhui Zhou, Jaeki Min
-
Patent number: 8153788Abstract: Compounds of the formula (I) or salts thereof, in which in which R1 is an optionally substituted amino group or analogous group, and R2 to R7 are each as described herein, are suitable as herbicides and crop growth regulators. The compounds (I) can be prepared by the processes described, via intermediates including novel intermediates for example of the formula (III).Type: GrantFiled: December 14, 2007Date of Patent: April 10, 2012Inventors: Hartmut Ahrens, Hansjörg Dietrich, Thomas Auler, Martin Hills, Heinz Kehne, Dieter Feucht, Stefan Herrmann, Kristian Kather, Stefan Lehr
-
Patent number: 8138338Abstract: The present invention provides, at least in part, compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z1, Z2, Z3, R1, x, y, R2, R3, R4a, R4b, R5, R6 and R7 are described herein, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use as Aurora A kinase inhibitors in treatment, e.g., of cancer and other proliferative disorders.Type: GrantFiled: July 27, 2007Date of Patent: March 20, 2012Assignee: GlaxoSmithKline LLCInventor: Matthew Clark
-
Publication number: 20120063976Abstract: Methods of removing carbon dioxide comprising contacting a gas mixture comprising carbon dioxide with a sorbent. The sorbent comprises the following chemical structure: wherein at least one of R1, R2, and R3 comprises a primary amine group and wherein the sorbent is not melamine and does not comprise the following chemical structure: Sorbents for removing carbon dioxide are also disclosed.Type: ApplicationFiled: September 9, 2010Publication date: March 15, 2012Applicant: BATTELLE ENERGY ALLIANCE, LLCInventor: Michael T. Benson
-
Patent number: 8119798Abstract: Compounds of formula (I) and (II) are disclosed, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use in treating disease. The compounds inhibit the production of TNF-alpha and interleukins (IL) by the inhibition of p38 kinase. They are useful in the treatment of inflammation and arthritis.Type: GrantFiled: August 1, 2007Date of Patent: February 21, 2012Assignee: GlaxoSmithKline LLCInventor: Matthew Clark
-
Patent number: 8076477Abstract: Use of an affinity adsorbent for the separation, removal, isolation, purification, characterisation, identification or quantification of a proteinaceous material, wherein the affinity adsorbent is a compound of formula (III), wherein R1 is H, alkyl, aryl, hydroxyalkyl, cyciohexyl, amino or a heterocyclic group which is optionally substituted with one or more of alkyl, aryl, alkoxy, aryloxy, acyloxy, acylamino, amino, OH, CO2H, sulphonyl, carbamoyl, sulphamoyl, alkylsuiphonyl and halogen; one X is N and the other is N, C—Cl or C—CN; Y is O, S or NR2; Z is O, S or NR3; R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or ?-phenylethyl; Q is benzene, naphthalene, benzthiazole, benzoxazole, 1-phenylpyrazole, indazoie or benzimidazoie; R4, R5 and R6 are each H, OH, alkyl, aryl, heterocyclic, alkoxy, aryloxy, amino, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, suiphamoyl, alkylsulphonyl or halogen, or two or more of R4, R5 and R6 are linked to form a cyclic structure; U and V are the same or different C1-10Type: GrantFiled: March 2, 2007Date of Patent: December 13, 2011Assignee: ProMetic BioSciences Ltd.Inventors: Jason Richard Betley, Helen Tatton, Kelly Le Riche, Matthew Webb
-
Publication number: 20110295001Abstract: The present invention relates to a method for producing triazine carbamates by conversion of at least one triazine with at least one chloroformate in the presence of at least one alkaline or alkaline earth metal compound, wherein the alkaline or alkaline earth metal compound is not present in form of an alcoholate.Type: ApplicationFiled: December 7, 2009Publication date: December 1, 2011Applicant: BOREALIS AGROLINZ MELAMINE GMBHInventors: René Dicke, Martin Burger, Andreas Endesfelder, Christoph Hahn, Sven Poser, Willy Frank, Manfred Arnold
-
Patent number: 8044197Abstract: Radiation-curable 1,3,5-triazine carbamates and 1,3,5-triazine ureas, processes for preparing them and their use.Type: GrantFiled: April 8, 2005Date of Patent: October 25, 2011Assignee: BASF SEInventors: Yvonne Heischkel, Joerg Schneider, Reinhold Schwalm, Guenter Scherr
-
Patent number: 8034929Abstract: The invention relates to a process for preparing polymethylolated melamine and polymethylolated melamine compounds polyetherified with alkanol, wherein the methylolation reaction is carried out in a kneading reactor.Type: GrantFiled: January 13, 2005Date of Patent: October 11, 2011Assignee: BASF SEInventors: Jörg Schneider, Günter Scherr, Rainer Erhardt, Andreas Eichfelder, Martin Reif, Stefan Hirsch, Hans Schupp, Christel Hittinger, Alain Robert
-
Patent number: 8030485Abstract: The invention relates to a process for preparing free-flowing, pulverulent alkoxycarbonylaminotriazine from an alkanolic reaction mixture which is obtained in the preparation of alkoxycarbonylaminotriazines and comprises at least one alkoxycarbonylaminotriazine, at least one cyclic and/or acyclic carbonic ester, at least one C1-C13-alkanol which optionally comprises one or two oxygen atoms in the form of ether bonds and is optionally substituted by C1-C4-alkyl and/or hydroxyl, and also at least one alkali metal or alkaline earth metal alkoxide, with or without melamine and with or without catalyst, by atomizing and drying the reaction mixture in a spray drier.Type: GrantFiled: May 31, 2006Date of Patent: October 4, 2011Assignee: BASF AktiengesellschaftInventors: Joerg Schneider, Guenter Scherr, Rainer Erhardt, Andreas Eichfelder, Martin Reif, Stefan Hirsch, Georg Sieder, Thomas Holtmann, Juergen Ciprian, Hermann Ascherl
-
Patent number: 8030484Abstract: Compounds of formula (I) wherein R1 and R2 are the same or different and are each optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl groups; R3 is hydrogen or an aryl group substituent or R3 is a solid support optionally attached via a spacer; Z represents an oxygen atom, a sulphur atom or NR4; Y represents an oxygen atom, a sulphur atom or NR5; in which R4 and R5, which may be the same or different, represent hydrogen, optionally substituted alkyl containing 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted benzyl or optionally substituted ?-phenylethyl; and one of X1 and X2 represents a nitrogen atom and the other of X1 and X2 represents a nitrogen atom or CR6, in which R6 represents hydrogen or an aryl group substituent; are useful for the affinity binding of a prion protein.Type: GrantFiled: July 25, 2005Date of Patent: October 4, 2011Assignee: Prometic Biosciences LimitedInventors: James Christopher Pearson, Helen Rosemary Tatton, Patrick Vasconcelos Gurgel
-
Patent number: 7999101Abstract: The present invention relates to cationic lipids capable of forming complexes with nucleic acids and the use thereof for the transfection of eukaryotic cells. The cationic lipids according to the invention have general formulas (I) and (Ia): (see formulas (I) and (Ia), wherein E is a heteroaryl; R1 and R2 are selected from H, —R7—NH2, alkyl; R7 is selected from alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl-(C0-C20) alkyl; R3 and R4 are selected from: H, —R8—SH, R8—NH—NH2/—R8—CO—R9 or —R8—NH2; R8 is selected from: alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl-(C0-C20) alkyl; R9 is selected from: H, alkyl; R5 and R6 are selected from: H, alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl.Type: GrantFiled: February 13, 2006Date of Patent: August 16, 2011Assignee: Politecnico Di MilanoInventors: Matteo Zanda, Luca Bruche′, Massimo Frigerio, Fiorenza Viani, Luca Chiamenti, Walter Panzeri, Nadia Zaffaroni, Marco Folini, Maria Angela Greco
-
Patent number: 7989619Abstract: The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.Type: GrantFiled: July 13, 2006Date of Patent: August 2, 2011Assignee: Innovative Surface Technoloiges, Inc.Inventors: Patrick Guire, Kristin Taton, Jie Wen, Laurie R. Lawin
-
Publication number: 20110178212Abstract: The invention relates to a method for producing at least one compound having at least one at least monosubstituted amino group. According to the invention, a starting substance having at least one amino group is reacted with an alcohol in a reaction mixture in the presence of ammonia.Type: ApplicationFiled: March 27, 2009Publication date: July 21, 2011Applicant: BOREALIS AGROLINZ MELAMINE GMBHInventors: Rene Dicke, Andreas Endesfleder, Martin Burger, Christoph Hahn, Clemens Schwarzinger, Wolfgang Fuerst, Harald Schmidt
-
Patent number: 7982034Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.Type: GrantFiled: April 7, 2009Date of Patent: July 19, 2011Assignee: Koronis Pharmaceuticals, IncorporatedInventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
-
Publication number: 20110105654Abstract: The invention relates to a method for producing a compound having at least one mono substituted amino group. According to the invention, a starting substance supporting at least one amino group as reacted with a reagent supporting a first functional group and at least one other functional group in a reaction mixture. The first functional group is a hydroxyl group and the at least one other functional group is selected from hydroxyl groups, mercapto groups, carboxylic acid groups, carboxylic acid ester groups, carboxylic acid amide groups, keto groups, carbonate groups, halogens, epoxy groups and carbamate groups. If several other functional groups are present, the groups are selected independently of one another from the aforementioned class. Melamine, urea and guanamine are, in particular, reacted with glycol, glycerine and hydroxyl acetic acid derivatives.Type: ApplicationFiled: March 27, 2009Publication date: May 5, 2011Applicant: BOREALIS AGROLINZ MELAMINE GMBHInventors: Rene Dicke, Martin Burger
-
Publication number: 20110003989Abstract: A melamine skeleton-bearing organosilicon compound has a film forming ability, water solubility and compatibility with resins. It is prepared by reacting cyanuric chloride with a primary and/or secondary amine compound and neutralizing with a base.Type: ApplicationFiled: June 30, 2010Publication date: January 6, 2011Inventor: Kazuhiro TSUCHIDA
-
Patent number: 7838520Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.Type: GrantFiled: March 15, 2005Date of Patent: November 23, 2010Assignee: MethylGene, Inc.Inventors: Daniel Delorme, Soon Hyung Woo, Arkadii Vaisburg, Oscar Moradei, Silvana Leit, Stephane Raeppel, Sylvie Frechette, Giliane Bouchain, Zhihong Zhou
-
Publication number: 20100292409Abstract: The present invention relates to triazine derivatives of the general formula (I), their use and production.Type: ApplicationFiled: May 29, 2008Publication date: November 18, 2010Applicant: BOREALIS AGROLINZ MELAMINE GMBHInventors: Rene Dicke, Martin Burger, Christoph Hahn, Andreas Endersfelder
-
Publication number: 20100243455Abstract: The present invention relates to an electrodepositable coating composition comprising a crater control additive.Type: ApplicationFiled: March 31, 2009Publication date: September 30, 2010Inventors: Ellor James Van Buskirk, Alan J. Kaylo, Michael G. Sandala, Debra L. Singer, Benjamin Kabagambe, Joseph R. Swanger
-
Publication number: 20100227186Abstract: A process for the production of leather using one or more reaction products of (a) triamines or higher amines with (b) at least one compound of the general formula I A1-R1??I where R1 is selected from hydrocarbon radicals having 10 to 5000 carbon atoms, straight-chain or branched, saturated or having from one to three C—C double bonds, and A1 from groups capable of reacting with amines.Type: ApplicationFiled: August 8, 2007Publication date: September 9, 2010Applicant: BASF SEInventors: Stephan Hüffer, Sebastien Garnier, Oliver Reese, Günter Scherr, Harald Kiesow
-
Patent number: 7772393Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.Type: GrantFiled: June 12, 2006Date of Patent: August 10, 2010Assignee: Innovative Surface Technologies, Inc.Inventors: Patrick Guire, Kristin Taton, Jie Wen
-
Publication number: 20100143354Abstract: The present invention relates to new triazine DNA modifiers, pharmaceutical compositions thereof, and methods of use thereofType: ApplicationFiled: December 4, 2009Publication date: June 10, 2010Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Thomas G. Gant, Sepehr Sarshar
-
Patent number: 7718655Abstract: Trisubstituted triazines can be synthesized from cyanuric chloride. These compounds are useful anti-tubulin agents for treating cancer and proliferative diseases.Type: GrantFiled: June 20, 2003Date of Patent: May 18, 2010Assignee: New York UniversityInventors: Young-Tae Chang, Alexander Schier, Ho-Sang Moon, Eric Jacobson, Puja Parikh
-
Patent number: 7645496Abstract: A compound of formula (A): wherein L1 and L2 each independently are a single bond or a divalent linking group, R1 and R2 each independently are a hydrogen atom or a substituent, and R is a group having a polymerizable group; and a composition, containing at least one of the compound; an optically anisotropic material, containing the compound or the composition; and a liquid crystal display device, containing the optically anisotropic material.Type: GrantFiled: June 15, 2007Date of Patent: January 12, 2010Assignee: Fujifilm CorporationInventors: Shigeki Uehira, Hiroshi Takeuchi
-
Patent number: 7645877Abstract: The present invention relates to unsymmetrical and symmetrical phosphorus-comprising heptazine derivatives, represented by the formula (1): in which Ra, Rb and Rc are, independently of one another, an azide group —N3 or an —N?PR1R2R3 group, with the proviso that at least one radical from Ra, Rb and Rc is an —N?PR1R2R3 group, to a process for the preparation thereof and to the use thereof.Type: GrantFiled: September 14, 2005Date of Patent: January 12, 2010Assignees: Zylum Beteiligungsgesellschaft mbH & Co., Patente II KGInventors: Tobias Gmeiner, Edwin Kroke, Marcus Schwarz
-
Patent number: 7595343Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.Type: GrantFiled: September 12, 2002Date of Patent: September 29, 2009Assignee: MethylGene, Inc.Inventors: Daniel Delorme, Soon Hyung Woo, Arkadii Vaisburg, Oscar Moradei, Silvana Leit, Stephane Raeppel, Sylvie Frechette, Giliane Bouchain
-
Patent number: 7589092Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.Type: GrantFiled: December 27, 2006Date of Patent: September 15, 2009Assignee: Koronis Pharmaceuticals, IncorporatedInventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
-
Patent number: 7517474Abstract: New triazine derivatives containing carbamate groups, processes for preparing them, and their use.Type: GrantFiled: April 8, 2005Date of Patent: April 14, 2009Assignee: BASF AktiengesellschaftInventors: Eva Wagner, Reinhold Schwalm, Joerg Schneider, Rainer Erhardt, Carl Jokisch, Heinz-Peter Rink
-
Patent number: 7511136Abstract: Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.Type: GrantFiled: September 19, 2002Date of Patent: March 31, 2009Assignee: Pfizer Italia S.r.l.Inventors: Raffaella Amici, Matteo D'Anello, Katia Martina, Barbara Salom, Anna Vulpetti
-
Patent number: 7507818Abstract: In a process for preparing alkoxycarbonylaminotriazines, di- or triaminotriazines are reacted with cyclic carbonic esters and optionally with minor amounts of acyclic carbonic esters in the presence of an alcohol and of an alkali metal alkoxide or alkaline earth metal alkoxide as a base.Type: GrantFiled: December 16, 2003Date of Patent: March 24, 2009Assignee: BASF AktiengesellschaftInventors: Joerg Schneider, Guenter Scherr, Hans Schupp, Andreas Eichfelder, Alain Robert, Martin Reif
-
Patent number: 7482625Abstract: Provided are a composition for thermosetting organic polymeric gate insulating layer and an organic thin film transistor using the same. The composition for thermosetting organic polymeric gate insulating layer contains a thermosetting material in polyvinyl phenol as an organic polymeric gate insulating layer material, to improve a chemical resistance and an insulating property, and an organic thin film transistor includes a thermosetting organic polymeric gate insulating layer formed of the composition. The composition for thermosetting organic polymeric gate insulating layer endows an organic polymer with a thermosetting property, thereby being capable of improving the chemical resistance and the insulating property as well as of forming a layer having a device property improved.Type: GrantFiled: August 16, 2005Date of Patent: January 27, 2009Assignee: Electronics and Telecommunications Research InstituteInventors: Gi Heon Kim, Sung Min Yoon, In Kyu You, Seung Youl Kang, Seong Deok Ahn, Kyu Ha Baek, Kyung Soo Suh
-
Patent number: 7371856Abstract: A process is described for preparing alkoxycarbonylaminotriazines by reacting di- or triaminotriazines with dimethyl carbonate in the presence of an alcohol and of an alkali metal or alkaline earth metal methoxide base.Type: GrantFiled: December 12, 2006Date of Patent: May 13, 2008Assignee: BASF AktiengesellschaftInventors: Joerg Schneider, Guenter Scherr, Hans Schupp, Andreas Eichfelder, Alain Robert, Martin Reif
-
Patent number: 7332490Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.Type: GrantFiled: May 25, 2006Date of Patent: February 19, 2008Assignee: Reddy US Therapeutics, Inc.Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
-
Patent number: 7332488Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.Type: GrantFiled: August 28, 2006Date of Patent: February 19, 2008Assignee: Reddy US Therapeutics, Inc.Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
-
Patent number: 7268134Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.Type: GrantFiled: September 27, 2004Date of Patent: September 11, 2007Assignee: Reddy US Therapeutics, Inc.Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
-
Patent number: 7265114Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.Type: GrantFiled: November 22, 2005Date of Patent: September 4, 2007Assignee: Reddy US Therapeutics, Inc.Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Yeleswarapu Koteswar Rao, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
-
Patent number: 7244732Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.Type: GrantFiled: March 31, 2004Date of Patent: July 17, 2007Assignee: Koronis Pharmaceuticals, IncorporatedInventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
-
Patent number: 7217820Abstract: The invention relates to the use of enaminotriazines of the formula I in which the radicals Y, independently of one another, are hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms, the radicals X are identical or different, where at least one of the radicals X is the ethenyl radical of the formula II and X may also have the meanings of Y, and where in the formula II the radicals R are identical or different and are cyano, optionally esterified carboxyl, substituted carbonyl, optionally substituted aminocarbonyl, optionally esterified sulfo, substituted sulfonyl or optionally esterified phosphono, and where two adjacent radicals R may optionally form a ring and the radicals R? are identical or different and are hydrogen, an optionally substituted aliphatic, cycloaliphatic or aromatic radical having in each case up to 18 carbon atoms, as UV filters in cosmetic or pharmaceutical preparations for protecting human skin oType: GrantFiled: November 10, 2004Date of Patent: May 15, 2007Assignee: BASF AktiengesellschaftInventors: Thomas Heidenfelder, Kristin Tiefensee, Thomas Wünsch
-
Patent number: 7169923Abstract: A process is described for preparing alkoxycarbonylaminotriazines by reacting di- or triaminotriazines with dimethyl carbonate in the presence of an alcohol and of an alkali metal or alkaline earth metal methoxide base.Type: GrantFiled: October 23, 2002Date of Patent: January 30, 2007Assignee: BASF AktiengesellschaftInventors: Joerg Schneider, Guenter Scherr, Hans Schupp, Andreas Eichfelder, Alain Robert, Martin Reif
-
Patent number: 7169785Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.Type: GrantFiled: March 26, 2003Date of Patent: January 30, 2007Assignee: Reddy US Therapeutics, Inc.Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishma Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
-
Patent number: 7064125Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.Type: GrantFiled: November 13, 2003Date of Patent: June 20, 2006Assignee: Cell Therapeutics, Inc.Inventors: Baoqing Gong, John Tulinsky, Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung
-
Patent number: 7038046Abstract: There are described triazine derivatives of formula (1), wherein R1 is an unsubstituted or mono- or poly-hydroxy-, C1-C18 alkyl-, C1-C18 alkoxy-, amino-, C1-C5 monoalkylamino- or di-C1-C5 alkylamino-substituted C1-C18 alkyl, C2-C18 alkenyl, C6-C10 aryl or C6-C10 heteroaryl radical; unsubstituted or C1-C5 alkyl-substituted C5-C7 cycloalkyl or C5-C7 cycloalkenyl; —OR?; or —NR?R?; R2 is hydrogen; an unsubstituted or mono- or poly-hydroxy-, C1-C18 alkoxy-, cyano-, amino, C1-C5 monoalkylamino- or di-C1-C5 alkylamino-substituted C1-C18 alkyl, C2-C18 alkenyl; C6-C10 aryl or C6-C10 heteroaryl radical; —OR?; or —NR?R?; or R1 and R2 together form a 5- to 7-membered carbocyclic or heterocyclic ring; A is C1-C5 alkyl; an unsubstituted or hydroxy-, C1-C18 alkyl- or C1-C18 alkoxy-substituted C6-C10 aryl or heteroaryl radical; or a radical of formula (1a); R? and R? are each independently of the other hydrogen; unsubstituted or mono- or poly-hydroxy-, halo-, C1-C18 alkyl-, C1-C18 alkoxy-, amino- or quaternary ammonium groupType: GrantFiled: August 8, 2002Date of Patent: May 2, 2006Assignee: Ciba Specialty Chemicals CorporationInventor: Barbara Wagner
-
Patent number: 6878824Abstract: The present invention provides a process for preparing N-methylated melamines in simple steps by using inexpensive raw materials in such a manner that the proportion of mono-type, bis-type and tris-type of the N-methylated melamines as prepared can be controlled. The process comprises reacting by heating melamine with methylamine in the presence of an acidic catalyst under pressure to substitute at least one amino group of the melamine by methylamino group.Type: GrantFiled: March 19, 2003Date of Patent: April 12, 2005Assignee: Nissan Chemical Industries, Ltd.Inventors: Isao Hashiba, Takayuki Tamura, Hiroyuki Kousaka
-
Patent number: 6858608Abstract: The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which inhibits telomerase. It also relates to novel chemical compounds as well as their therapeutic application in humans.Type: GrantFiled: January 9, 2002Date of Patent: February 22, 2005Assignee: Aventis Pharma S.A.Inventors: Patrick Mailliet, Jean-François Riou, Marcel Alasia, Thomas Caulfield, Gilles Doerflinger, Jean-Louis Mergny, Abdelazize Laoui, Odile Petitgenet, Emmanuelle Renou
-
Patent number: 6818768Abstract: Mixtures of triazine derivatives free from polyalkylene oxide Mixtures of triazine derivatives free from polyalkylene oxide are produced from 20 to 70 percent by weight of triazine derivatives with hydroxyalkyl amino groups and 80 to 30 percent by weight of triazine derivatives with bis(hydroxyalkyl) imino groups by catalytic reaction of alkylpropylene oxides with triazine derivatives at a melamine derivative/alkylpropylene oxide molar ratio of 1:1.5 to 1:10 in the presence of metal alkyls, metal hydrides, metal alcoholates and/or metal alkylamides as catalysts. The triazine derivative/hydroxy group mixtures free from polyalkylene oxide are particularly suited for producing plastic materials, flame retardants, additives, pharmaceuticals, textile auxiliaries, and paints or finishes.Type: GrantFiled: July 25, 2002Date of Patent: November 16, 2004Assignee: Agrolinz Melamin GmbHInventors: Manfred Rätzsch, Martin Burger, Manfred Arnold, Willy Frank
-
Patent number: 6818726Abstract: Polymers are prepared from A) 60 to 95 percent by weight of a mixture including A1) 20 to 70 percent by weight of hydroxyalkyl amino triazines and A2) 30 to 80 percent by weight of bis(hydroxyalkyl) amino triazines B) 5 to 40 percent by weight of polyfunctional compounds selected from one or more of B1) polyisocyanates and/or oligomeric polyesters or polyethers with isocyanate end groups, B2) aliphatic dicarboxylic acids, esters, chlorides or anhydrides, or aromatic polybasic acids, esters, chlorides or anhydrides, B3) aliphatic or aromatic diglycidal compounds or triglycidyl compounds, and, optionally, C) 1 to 20 percent by weight of aliphatic, cycloaliphatic or aromatic dihydroxy compounds, polyalkylene glycols and aliphatic aldehydes.Type: GrantFiled: July 25, 2002Date of Patent: November 16, 2004Assignee: Agrolinz Melamin GmbHInventors: Manfred Rätzsch, Martin Burger, Manfred Arnold, Willy Frank
-
Patent number: 6797821Abstract: The present invention discloses an active-hydrogen-containing phosphorus compound for cross-linking a resin and for imparting flame-retardancy to the cured resin, and in particular to a cured frame-retardant epoxy resin prepared by reacting the hardener with a di- or poly-functional epoxy resin via an addition reaction between the active hydrogen and the epoxide group. The present invention also discloses an epoxy resin made from the active-hydrogen-containing phosphorus compound and epihalohydrin.Type: GrantFiled: January 30, 2002Date of Patent: September 28, 2004Inventors: Chun-Shan Wang, Jeng-Yueh Shieh, Ching Hsuan Lin
-
Patent number: 6756431Abstract: Heterocyclic tin compounds, useful as flame retardants and/or as smoke suppressants for halogen-containing polymers, e.g., polyvinyl chloride resins having application as wire and cable coatings, are obtained by reacting a trisubstituted triazine such as melamine with a tin-containing compound such as tin tetrachloride.Type: GrantFiled: April 9, 2002Date of Patent: June 29, 2004Assignee: Crompton CorporationInventors: Mukund Shah, Michael H. Fisch, Ulrich Stewen, Radu Bacaloglu