Three Substituent Nitrogens Bonded Directly To The Three Carbons Of The Triazine Ring Patents (Class 544/196)
  • Patent number: 6696445
    Abstract: The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY1 receptor. The present invention provides novel, potent, non-peptidic antagonists of NPY receptors, particularly, the NPY1 receptors, designed from a selection of mono-, bi-, or tri-cyclic heterocyclic cores. This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of the formula I-XV.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: February 24, 2004
    Assignees: Neurogen Corporation, Pfizer Inc.
    Inventors: Raymond F. Horvath, Jennifer N Tran, Stéphane De Lombaert, Kevin J. Hodgetts, Philip A. Carpino, David A. Griffith
  • Patent number: 6683151
    Abstract: The invention relates to a compound comprising a reaction product of (A) an isocyanate functional compound of which at least 40 wt. %, relative to the total amount of (A), has a molecular weight of at least about 500, and (B) a nitrogen-containing compound capable of reacting with said isocyanate functional compound (A). The reaction product has a molecular weight of less then about 20,000 and comprises an effective amount of groups that are able to form reversible intermolecular physical interactions such that a resulting compound shows polymeric mechanical properties at a temperature below a transition temperature. The nitrogen-containing compound is, for instance, melamine, urea, acetoguanamine, benzoguanamine, cyanamide, dicyanamide, thiourea, isocytosine, pyrimidone or aminopyridine. The supramolecular compound comprising a suitable amount of the reaction products exhibits a relatively high elongation at break.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: January 27, 2004
    Assignee: DSM N.V.
    Inventors: Jacobus A. Loontjens, Johan E. G. A. Jansen, Bartholomeus J. M. Plum
  • Patent number: 6680315
    Abstract: This invention relates to triazine compounds of formula (I): R1 is, aryl, or heteroaryl; each of R2, R4, and R5, independently, is Rc, halogen, nitro, nitroso, cyano, azide, isothionitro, SRc, or ORc; R3 is Rc, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; n is 0, 1, 2, 3, 4, 5, 6, or 7; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), or S(O2); Z is N; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, or alkylcarbonyl.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: January 20, 2004
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Mitsunori Ono, Lijun Sun, Shijie Zhang, Teresa Przewloka, David A. James, Wenli Ding, Yumiko Wada
  • Patent number: 6673924
    Abstract: The present invention includes a precursor compound pertaining to a 1,2,4-Triazolo[4,3-a][1,3,5] Triazine compound, particularly a 1,2,4-Triazolo[4,3-a][1,3,5] Triazine-3,5,7-Triamine, and novel fused ring structures such as triazolyl-tetrazinyl-aminotriazine compounds, and complexes and salts thereof, and other such chemical structures.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: January 6, 2004
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: William M. Koppes, Michael E. Sitzmann
  • Patent number: 6632305
    Abstract: The present invention includes a precursor compound pertaining to a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine compound, particularly a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine-3,5,7-Triamine, and novel fused ring structures such as triazolyl-tetrazinyl-aminotriazine compounds, and complexes and salts thereof, and other such chemical structures.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: October 14, 2003
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: William M. Koppes, Michael E. Sitzmann
  • Publication number: 20030143481
    Abstract: An image forming material includes an image forming layer containing a water-insoluble and alkali-soluble resin, a light-heat converting agent and a compound represented by the following general formula (1). In general formula (1), R1 to R3 independently represent an organic group, where R1 represents a residue forming a ring containing a N1 atom, R2 and R3 may bond to each other to form a ring or at least one of R2 and R3 may bond to R1 to form a ring and X− represents a conjugate base of an organic acid or inorganic acid. The ring containing the N1 atom is preferably a piperidine ring.
    Type: Application
    Filed: July 24, 2002
    Publication date: July 31, 2003
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Kaoru Iwato, Tadahiro Sorori
  • Publication number: 20030125554
    Abstract: The invention concerns a method for cyclotrimerization of isocyanate functions by action of a catalyst based on quaternary ammonium or phosphonium. The invention is characterised in that said isocyanate functions are branched and said onium ions are selected among those whereof the total amount of carbons is not more than 30 and not less than 12; and whereof the counterion is selected among the anions corresponding to weak acids whereof the pKA is not less than 8, preferably not less than 10, more preferably not less than 12, whereof the substituents are aliphatic compounds and do not have an insaturation in beta; and said onium ions comprise at least 2 radicals of more than 6, advantageously more than 10, preferably more than 12 carbon atoms.
    Type: Application
    Filed: November 12, 2002
    Publication date: July 3, 2003
    Inventors: Jean-Marie Bernard, Frederic Dallemer, Denis Revelant
  • Patent number: 6555683
    Abstract: In the proposed condensation product based on amino-s-triazines with at least two amino groups, formaldehyde and sulphite, the molar ratio of amino-s-triazine, formaldehyde and sulphite is 1:2.5-6.0:1.51-2.0 and the formiate content is less than 0.3 wt %. The condensation product is obtained by a) heating amino-s-triazine, formaldehyde and a sulphite in the molar ratio 1:2.5-6.0:1.51-2.0 in an aqueous solution at a temperature of 60-90° C. and a pH level of between 9.0 and 13.0 until the sulphite can no longer be detected; b) continuing the condensation at a pH level of between 3.0 and 6.5 and a temperature of 60-80° C. until the condensation product has a viscosity of 5-50 mm/s at 80° C.; and c) adjusting the pH level of the condensation product to 7.5-12.0 or carrying out thermal secondary treatment at a pH level of >10.0 and a temperature of 60-100° C. The product can be used as an additive for inorganic binders such as cement.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: April 29, 2003
    Assignee: SKW Polymers GmbH
    Inventors: Josef Weichmann, Aloisia Stadler, Alfred Kern
  • Publication number: 20030044363
    Abstract: The invention relates to the use of enaminotriazines of the formula I 1
    Type: Application
    Filed: May 13, 2002
    Publication date: March 6, 2003
    Inventors: Thomas Heidenfelder, Kristin Tiefensee, Thomas Wunsch
  • Patent number: 6517742
    Abstract: The invention relates to new s-triazine derivatives of the formula (I): in which R1 represents an —NH—F radical, wherein F is a screening chromophore; R2 represents an —NH—Z—W radical, wherein Z is a divalent radical providing the connection between —NH— and —W, and W is a silicone-containing radical; and R3 is R1, R2, a linear or branched C1-C20 alkyl radical, a linear or branched C2-C20 hydroxyalkyl radical, a linear or branched C1-C20 alkoxy radical, an NHR8 radical or an N(R8)2 radical, with R8 being a linear or branched C1-C20 alkyl radical. The compounds of the invention are useful as organic sunscreen agents in cosmetic compositions intended for the protection of the skin and the hair against ultraviolet radiation. The invention also relates to the use of the compounds in cosmetic applications and to cosmetic compositions with improved properties containing these compounds.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: February 11, 2003
    Assignee: L'Oreal
    Inventors: Hervé Richard, Madeleine Leduc
  • Patent number: 6506898
    Abstract: Provided is a process for preparing an at least bis-carbamate functional 1,3,5-triazine by contacting an at least diamino-1,3,5-triazine, an acyclic organic carbonate and a base, as well as certain novel compositions producible thereby. Also provided are substantially halogen contamination free crosslinker compositions comprising the products obtainable by the process, and curable compositions based upon these crosslinkers.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: January 14, 2003
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Vankatarao K. Pai
  • Patent number: 6455695
    Abstract: The present invention provides a process which enables easy and inexpensive preparation of alkylenebismelamines usable as components for forming resin materials, particularly aminoplasts, and flame retardants. The present invention is a process for preparation of alkylenebismelamines wherein the alkylene is a linear or branched C2-10 one by reacting an alkylenediamine wherein the alkylene is a linear or branched C2-10 one with melamine in the presence of an acidic catalyst under heating, characterized in that the amount of melamine is at least twice that of the alkylenediamine by mole.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: September 24, 2002
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Hiroyuki Kousaka, Yasuyuki Nakajima
  • Patent number: 6448398
    Abstract: A process is disclosed for preparing acid amides, including isocyanate-functional 1,3,5-triazines and isocyanate-based 1,3,5 triazine derivatives, from the reaction of (Si, Ge or Sn substituted amino)-1,3,5 triazines and acid halides.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: September 10, 2002
    Assignee: Cytec Technology Corp.
    Inventor: William Elliott Bay
  • Publication number: 20020111457
    Abstract: Reaction products of the reactants comprising
    Type: Application
    Filed: December 13, 2001
    Publication date: August 15, 2002
    Inventor: Wei Li
  • Patent number: 6399047
    Abstract: Compounds of formula (I), wherein the groups are as defined in the disclosure, as well as the use thereof in cosmetic compositions and in the stabilization of synthetic polymers.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: June 4, 2002
    Assignee: 3V Sigma S.p.A.
    Inventors: Giuseppe Raspanti, Giorgio Zanchi
  • Patent number: 6384032
    Abstract: The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: May 7, 2002
    Assignee: Shionogi Bioresearch Corp.
    Inventors: Mitsunori Ono, Yumiko Wada, Beatrice Brunkhorst, Tadeusz Warchol, Wojciech Wrona, Dan Zhou, Nha Huu Vo, Stephen Gillies
  • Patent number: 6372729
    Abstract: This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0, 1, 2, 3 or 4; R1 and R2 are each independently selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each of the aforementioned C1-12alkyl groups may optionally and each individually be substituted; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl, C1-6alkylcarbonyl, optionally substituted C1-6alkyl; and each R4 independently is hydroxy, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is —X—R5 or —X-Alk-R6; wherein R5 and R6 each independently are indanyl, indolyl or phenyl; each of
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: April 16, 2002
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frederik Frans Desiré Daeyaert, Bart De Corte, Marc René De Jonge, Jan Heeres, Chih Yung Ho, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici
  • Publication number: 20020032199
    Abstract: Amino-pyrimidine and amino-triazine derivatives having 5-HT7 antagonist activity for the treatment of sleeping disorders, depression, schizophrenia, anxiety, obsessive compulsive disorders, circadian rhythm disorders, ocular disorders and/or centrally and peripherally mediated hypertension are provided.
    Type: Application
    Filed: April 24, 2001
    Publication date: March 14, 2002
    Inventors: Michael A. Poss, Ashok V. Purandare, Ronald J. Mattson, Li-Qiang Sun
  • Publication number: 20010051720
    Abstract: The present invention describes 1,3,5-Triazine-2,4,6-tris-hydroxyalkyl acids of the general formula I 1
    Type: Application
    Filed: July 12, 2001
    Publication date: December 13, 2001
    Inventor: John J. Waldmann
  • Patent number: 6307046
    Abstract: The present invention provides a method for modifying melamine derivatives that can produce N-substituted melamine derivatives by introducing a substituent group to melamine or N-substituted melamine derivatives. The method is characterized by heating melamine or an N-substituted melamine derivative and an alcohol in the presence of a mixed catalyst comprising a hydrogenation catalyst and a dehydrogenation catalyst and hydrogen to allow reaction or heating melamine or an N-substituted melamine derivative and an alcohol in the presence of a hydrogenation catalyst and hydrogen with addition/coexistence of a metal to allow reaction. The compound groups obtained by introducing a substituent group to the amino group of melamine derivative with an alcohol by the method of the present invention can be used widely as intermediates of fine chemicals such as various agricultural chemicals, medicines, dyes, paints, etc. and as various resin materials and flame retardant materials.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: October 23, 2001
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Norio Tanaka, Hiroyuki Kousaka, Yasuyuki Nakajima, Kouichi Masahashi, Takashi Kitabayashi
  • Patent number: 6300498
    Abstract: The 1,5′-bitetrazole of the invention comprises 1,5′-bitetrazole, and ammonia or an amine. The 1,5′-bitetrazole of the invention decomposes sharply and generates a nontoxic gas.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: October 9, 2001
    Assignee: Toyo Kasei Kogyo Company Limited
    Inventors: Hiroaki Tanaka, Kunihiro Shimamoto, Atuhiro Onishi
  • Patent number: 6288226
    Abstract: Provided is a process for preparing an at least bis-carbamate functional 1,3,5-triazine by contacting an at least diamino-1,3,5-triazine, an acyclic organic carbonate and a base, as well as certain novel compositions producible thereby. Also provided are substantially halogen contamination free crosslinker compositions comprising the products obtainable by the process, and curable compositions based upon these crosslinkers.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: September 11, 2001
    Assignee: Cytec Technology Corporation
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Venkatarao K. Pai
  • Patent number: 6284717
    Abstract: The reaction product of: (i) a polyalkenyl derivative of an ethylenically unsaturated carboxylic reagent and (ii) a compound of the formula wherein R is a linear alkylene group having at least 2 carbon atoms, a branched alkylene group having at least 3 carbon atoms, a cycloalkylene group having at least 5 carbon atoms, in which one or more of said carbon atoms may be substituted by one or more hetero atoms, or is an aromatic group or a group of the formula in which a is 1 to 6 and b is 0 to 6, wherein the groups R may be the same or different, and wherein the values of a and b may be the same or different; process for the preparation of said reaction product; lubricating oil compositions, fuel compositions and additive concentrates containing such reaction products; and use of the reaction products as dispersant additives.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: September 4, 2001
    Assignee: Infineum USA L.P.
    Inventors: Anthony E. Crane, Richard M. Scott
  • Patent number: 6225378
    Abstract: A triazine compound having formula I or formula II: Wherein n is integer from 1 to 5; R1 is hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxyl; and R2 is aliphatic amine, aliphatic alcohol, alicyclic amine or alicyclic alcohol, and an epoxy resin composition containing the triazine compound. The epoxy resin composition is suitable for the preparation of the structural substrate of printed circuit boards having low dielectric constant.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: May 1, 2001
    Assignee: Industrial Technology Research Institute
    Inventors: Shin-Shin Wang, Hung-Chou Kang, Jie-Hwa Ma, Meng-Song Yin, Se-Tsun Hong, Kuo-Yuan Hsu, Kung-Lung Cheng
  • Patent number: 6204381
    Abstract: Disclosed is the preparation of 1,3,5-triazine carbamates which are suitable for use as crosslinking agents in curable compositions, particularly in coating compositions which are capable of curing at relatively low temperatures without releasing formaldehyde during cure. The process includes the step of contacting a 1,3,5-triazine derivative having cyanate-displaceable leaving groups (i.e. cyanuric chloride), a cyanate-containing reagent (i.e. potassium cyanate), and an isocyanate-reactive compound such as an alcohol, in the presence of a polar solvent or in the presence of a non-polar solvent in combination with a phase transfer catalyst.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: March 20, 2001
    Assignee: Cytec Technology Corp.
    Inventor: Hong Zhao
  • Patent number: 6150360
    Abstract: This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR.sup.4 or N; n is 0, 1, 2, 3 or 4; R.sup.1 and R.sup.2 are each independently selected from hydrogen, hydroxy, C.sub.1-12 alkyl, C.sub.1-12 alkyloxy, C.sub.1-12 alkylcarbonyl, C.sub.1-12 -alkyloxycarbonyl, aryl, amino, mono- or di(C.sub.1-12 alkyl)amino, mono- or di(C.sub.1-12 alkyl)aminocarbonyl wherein each of the aforementioned C.sub.1-12 alkyl groups may optionally and each individually be substituted; or R.sup.1 and R.sup.2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C.sub.1-12 alkyl)aminoC.sub.1-4 alkylidene; R.sup.3 is hydrogen, aryl, C.sub.1-6 alkylcarbonyl, optionally substituted C.sub.1-6 alkyl; and each R.sup.4 independently is hydroxy, halo, C.sub.1-6 alkyl, C.sub.1-6 -alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is --X--R.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: November 21, 2000
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frederik Frans Desire Daeyaert, Bart De Corte, Marc Rene De Jonge, Jan Heeres, Chih Yung Ho, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici
  • Patent number: 6130332
    Abstract: The object of the present invention is to provide a method for producing substituted-1,3,5-triazine derivatives at high yield, in which at least one of carbon atoms in the ring thereof is substituted by a secondary amine group having at leat one of alkyl groups. The method of the present invention is a method for alkylation of 1,3,5-triazine derivatives, characterized by reacting 1,3,5-triazine derivatives (melamines, melamine derivatives, various kinds of guanaminde derivatives, etc.) which has at least one or more amino groups or mono-substituted amino groups on carbon atom of the ring thereof, with aldehydes or ketones alcohols in the presence of a catalyst of a metal of group VII and/or group VIII in the periodic table and a hydrogen-containing gas to alkylate said at least one of amino groups or mono-substituted amino groups.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: October 10, 2000
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Norio Tanaka, Kenichi Mizusawa, Makoto Ishikawa, Yasuo Fukue, Isao Hashiba, Yoshihisa Watanabe
  • Patent number: 6127538
    Abstract: A method for modifying 1,3,5-triazine derivatives characterized by heating and reacting a 1,3,5-triazine derivatives having at least one amino or mono-substituted amino group on a carbon atom or atoms on its ring with an alcohol in the presence of a metal catalyst and a hydrogen atom to introduce an alkyl group or an alkenyl group into each amino or mono-substituted amino group; another method for modifying 1,3,5-triazine derivatives characterized by heating and reacting a 1,3,5-triazine derivatives having at least one amino or mono-substituted amino group on a carbon atom or atoms on its ring with a dihydric alcohol in the presence of a metal catalyst and a hydrogen atom to introduce an alkyl group having a hydroxyl group into each amino or mono-substituted amino group; and 1,3,5-triazine derivatives obtained by the methods. The various modified sustituted 1,3,5-triazine derivatives thus produced are generally obtained as a mixture.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: October 3, 2000
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Norio Tanaka, Yasuo Fukue, Kenichi Mizusawa, Makoto Ishikawa
  • Patent number: 6121446
    Abstract: The present invention relates to a method for preparing tris-substituted alkoxycarbonylamino-1,3,5-triazine compounds, which involves reacting a amino-1,3,5-triazine compound such as melamine, for example, in the presence of excess amounts of carbon monoxide and an alcohol, a sub-stoichiometric amount of a base, a catalyst system that includes a catalytic amount of a primary catalyst of a group VIII metal or metal salt, and a sub-stoichiometric amount of a co-catalyst of a group I-B or lanthanide series metal or metal salt. The reaction is conducted at a temperature, pressure and length of time sufficient to form a tris-substituted alkoxycarbonylamino-1,3,5-triazine compound in a yield of at least about 5 percent, with improved yields of more than 40 percent being conveniently obtained.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: September 19, 2000
    Assignee: Cytec Technology Corporation
    Inventor: Lawrence Allen Flood
  • Patent number: 6121445
    Abstract: A 1,3,5-triazine derivative salt of a polyacid comprising phosphorus, sulfur and oxygen, which has a solubility of from 0.01 to 0.10 g/100 ml in water (25.degree. C.) and a pH of from 2.0 to 7.0 as a 10 wt % aqueous slurry (25.degree. C.), and which is obtained from the following steps (a) and (b):(a) a step of obtaining a reaction product by mixing melamine, phosphoric acid and sulfuric acid at a temperature of from 0 to 330.degree. C. in such ratios that the melamine is from 1.0 to 4.0 mols per mol of the total molar amount of the phosphoric acid (as calculated as orthophosphoric acid content) and the sulfuric acid (as sulfuric acid content), and the sulfuric acid (as sulfuric acid content) is from 0.05 to 20 mols per mol of the phosphoric acid (as calculated as orthophosphoric acid content), and(b) a step of baking the reaction product obtained in step (a) at a temperature of from 340 to 400.degree. C. for from 0.1 to 30 hours; and a process for its production.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: September 19, 2000
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Keitaro Suzuki, Masuo Shindo, Motoko Iijima
  • Patent number: 6120562
    Abstract: Amino- and/or alkoxytriazines containing at least one C.sub.1 -C.sub.10 -alkyl group which possesses a vinylsulfonyl group or a radical capable of forming a vinylsulfonyl group and may be substituted further, are used as fixation aids when using anionic dyes on hydroxyl- or nitrogen-containing organic substrates and as crosslinkers for regenerated cellulose or materials containing cellulose.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: September 19, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Manfred Patsch, Reinhold Krallmann, Wolfgang Reuther, Thomas Grosser
  • Patent number: 6111102
    Abstract: Compounds of the formula I or salts thereof, in whichX is oxygen, --O--NR.sup.2 -- or --SO.sub.2 --NR.sup.2 --, and Y is N or CH,R.sup.1 is (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or (C.sub.2 -C.sub.6)alkynyl, which are in each case optionally substituted, or, in the case where X=oxygen, also (subst.) phenyl,R.sup.2 is H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or -alkynyl or (C.sub.3 -C.sub.6)cycloalkyl,R.sup.3 and R.sup.4 are H, (subst.) (C.sub.1 -C.sub.4)alkyl or (subst.) (C.sub.1 -C.sub.4)alkoxy or halogen, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)-alkylamino or di[(C.sub.1 -C.sub.4)alkyl]-amino,R.sup.5 is H or (C.sub.1 -C.sub.4)alkyl and R.sup.6 is hydrogen,may be prepared by reacting compounds of the formula II,R.sup.1 --X--R.sup.7 (II)with compounds of the formulae III, IV and VR.sup.8 --OCN (III)SO.sub.2 Cl.sub.2 (IV) ##STR1## where R.sup.7 and R.sup.8 are H, a quarternary ammonium ion or one equivalent of a metal cation.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: August 29, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Gunter Schlegel
  • Patent number: 6096244
    Abstract: The present invention relates to a melamine-polycarboxylic acid amide and its use as a corrosion protection agent. Specifically, a melamine-polycarboxylic acid amide having a particular Formula I ##STR1## as well as alkali, ammonium, and amine salts thereof.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: August 1, 2000
    Assignee: ZTS-Chemie GmbH
    Inventor: Stefan Graichen
  • Patent number: 6063922
    Abstract: Provided is a novel carbamate functional 1,3,5-triazine of the general formula ##STR1## wherein Z' is selected from the group consisting of hydrogen, hydrocarbyl, and a group represented by the formula NHQ',each Q' is independently selected from the group consisting of a hydrocarbyl, a hydrocarbyloxy hydrocarbyl and a group represented by the formula COOY, with the proviso that at least two of the Q' groups are COOY, andeach Y is independently selected from the group consisting of a hydrocarbyl group and a hydrocarbyloxy hydrocarbyl ether group, with the proviso that at least one Y group is a hydrocarbyloxy hydrocarbyl ether group. These carbamate functional 1,3,5-triazines find use, for example, as crosslinkers or reactive modifiers in curable compositions.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: May 16, 2000
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Vankatarao K. Pai
  • Patent number: 5854244
    Abstract: The present invention provides compounds of the formula (I) wherein each R.sup.1, which may be the same or different, is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, R.sup.2 is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH. The compounds are analogs of trimelamol which have comparable activity but enhanced stability, and are useful as anticancer agents, particularly against ovarian cancer.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: December 29, 1998
    Assignee: Cancer Research Campaign Technology Limited
    Inventors: Michael Jarman, Helen Mary Coley
  • Patent number: 5792867
    Abstract: A method for alkylation of at least one or more amino groups or mono-substituted amino groups, each on a carbon atom of a triazine ring of 1,3,5-triazine derivatives (melamine, melamine derivatives and various kinds of guanamine derivatives and the like), which includes reacting the 1,3,5-triazine derivatives having at least one or more amino groups or mono-substituted amino groups with alcohols in the presence of a catalyst of a metal of group VII and/or group VIII in the periodic table. The object of the invention is to provide a method for alkylation of 1,3,5-triazine derivatives, which includes alkylating amino groups or mono-substituted amino groups in carbon atoms of a 1,3,5-triazine ring, whereby substituted 1,3,5-triazine derivatives which are a group of useful compounds and which are widely used as intermediates of fine chemicals such as agricultural chemicals, medications, dye-stuffs, paints and the like, as resin materials and as flame-retardant materials can be easily produced in high yields.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: August 11, 1998
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Norio Tanaka, Masataka Hatanaka, Makoto Ishikawa, Yasuo Fukue, Isao Hashiba, Yoshihisa Watanabe
  • Patent number: 5792866
    Abstract: Provided is a process for preparing an at least bis-carbamate functional 1,3,5-triazine by contacting an at least diamino-1,3,5-triazine, an acyclic organic carbonate and a base, as well as certain novel compositions producible thereby. Also provided are substantially halogen contamination free crosslinker compositions comprising the products obtainable by the process, and curable compositions based upon these crosslinkers.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 11, 1998
    Assignee: Cytec Technology Corporation
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Vankatarao K. Pai
  • Patent number: 5792763
    Abstract: This invention provides novel 5-HT.sub.1F agonists of formula ##STR1## where X, Y, Z,and R are defined in the specification, which are useful for the prevention and treatment of migraine and associated disorders.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: August 11, 1998
    Assignee: Eli Lilly and Company
    Inventors: James E. Fritz, Stephen W. Kaldor, Sidney Xi Liang, Upinder Singh, Yao-Chang Xu
  • Patent number: 5760226
    Abstract: Binders compriseA) an aminotriazine derivative in which the primary amino groups of the triazine are methylolated on average with at least one mole of formaldehyde per mole of primary amino groups, and these methylol groups are etherified on average with at least 0.5 mol of primary alcohol per mole of methylol group and the primary alcohols are a mixture containinga) 0.5-99.5 mol % of a C.sub.1 -C.sub.4 -alkanol andb) 99.5-0.5 mol % of an alcohol of the formulaR.sup.1 --O--?R.sup.2 --O!.sub.n --R.sup.3 --OH I,in which R.sup.1 is C.sub.1 -C.sub.24 -alkyl or C.sub.6 -C.sub.12 -aryl which may be unsubstituted or substituted by from one to three C.sub.1 -C.sub.8 -alkyl groups, and R.sup.2 and R.sup.3 independently of one another are C.sub.2 -C.sub.8 -alkylene and n is an integer from 1 to 100, or of a mixture of higher-boiling alcohols having a boiling point of above 120.degree. C.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: June 2, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Manfred Niessner, Wolfram Weiss, Jurgen Tropsch, Matthias Kummer, Georg Meichsner
  • Patent number: 5744127
    Abstract: Compounds of formula (I) ##STR1## wherein the groups are as defined in the description, are useful as sunscreens in cosmetics and in the stabilization of synthetic polymers.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: April 28, 1998
    Assignee: 3V Inc.
    Inventors: Raspanti Giuseppe, Zanchi Giorgio
  • Patent number: 5712391
    Abstract: Disclosed are amino silicone derivatives having triazinyl groups or pyrimidinyl groups bound to amino groups of amino silicones, their production and use, said silicone derivatives being able to gel silicone oil or to increase the viscosity thereof stably and homogeneously, and therefore being useful as bases for cosmetics, pharmaceutical preparations and industrial materials.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: January 27, 1998
    Assignee: Chiba Flour Milling Co., Ltd.
    Inventors: Hiroyuki Ohno, Natsue Kawahara, Isaburo Amano, Takanao Suzuki, Koji Chiba
  • Patent number: 5705641
    Abstract: Provided is a process for preparing an at least bis-carbamate functional 1,3,5-triazine by contacting an at least diamino-1,3,5-triazine, an acyclic organic carbonate and a base, as well as certain novel compositions producible thereby. Also provided are substantially halogen contamination free crosslinker compositions comprising the products obtainable by the process, and curable compositions based upon these crosslinkers.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: January 6, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Vankatarao K. Pai
  • Patent number: 5703235
    Abstract: Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; orR.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.10 is hydrogen or C.sub.1 -C.sub.
    Type: Grant
    Filed: March 21, 1996
    Date of Patent: December 30, 1997
    Assignee: Neurogen Corporation
    Inventors: Jun Yuan, Xi Chen
  • Patent number: 5700295
    Abstract: The invention relates to compounds of formula ##STR1## wherein the variables have the meanings given in the claims. The compounds are suitable for use as UV absorbers for the photochemical stabilisation of undyed, dyed or printed textile fiber materials and for enhancing the sun protection factor thereof.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: December 23, 1997
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Francesco Fuso, Gerhard Reinert
  • Patent number: 5665688
    Abstract: A photoresist stripping composition containing:(a) 20-70% by weight of an organic polar solvent having a dipole moment of more than 3.5;(b) 70-20% by weight of alkanolamine compounds; and(c) 0.1-10% by weight of 6,6',6"-(1,3,5-triazine-2,4,6-triyltriimino) tris(hexanoic acid).
    Type: Grant
    Filed: January 23, 1996
    Date of Patent: September 9, 1997
    Assignee: Olin Microelectronics Chemicals, Inc.
    Inventors: Kenji Honda, Donald F. Perry, Taishih Maw
  • Patent number: 5641885
    Abstract: The present invention relates to carboxylated amino-1,3,5-triazines represented by the formula: ##STR1## wherein Z and Z.sup.1 are independently selected from the group consisting of hydrogen, a hydrocarbyl, a hydrocarbyloxy and a group represented by the formula --N(Q).sub.2 ; each Q is independently selected from the group consisting of hydrogen, a hydrocarbyl and a group Y, with the proviso that no more than one Q in each --N(Q.sub.2) is Y; and Y is selected from the group consisting of a carboxyl group and a carboxylate salt group. These carboxylated amino-1,3,5-triazines find use, for example, as intermediates in the production of other useful amino-1,3,5-triazine derivatives, particularly carbamate and isocyanate functional 1,3,5-triazines. The so-produced derivatives may find use as, for example, crosslinking agents in curable compositions.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: June 24, 1997
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence Allen Flood, Ram Baboo Gupta
  • Patent number: 5637704
    Abstract: A process for the preparation hydroxyoxaalkylmelamines of the general formula I ##STR1## in which R.sup.1 denotes a residue of the general formula II ##STR2## in which the radicals R' can be the same or different and stand for hydrogen or C.sub.1 -C.sub.4 alkyl and n denotes 2 or 3 and the radicals R.sup.2 and R.sup.3 stand for one of the radicals R.sup.1 or hydrogen, by the reaction of melamine with a compound of the general formula III ##STR3## in which R' and n have the meanings stated above, at a temperature of from 120.degree. to 250.degree. C. and in the presence of an acid catalyst, in which the acid catalyst is used in a concentration of from 0.01 to 0.15 mol and preferably from 0.02 to 0.12 mol and more preferably from 0.03 to 0.1 mol, based on 1 mol of melamine.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: June 10, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Erhard Guenther, Wolfgang Reuther, Gunter Scherr, Manfred Dimmler
  • Patent number: 5616708
    Abstract: Compounds of the following formula are provided: ##STR1## in which R.sup.1 represents a hydrogen atom or an optionally substituted alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, aryl or aralkyl group,A and B both represent a nitrogen atom, or represents a group CR.sup.5 and B represents a nitrogen atom or a group CR.sup.6 ;R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each independently represent a hydrogen or halogen atom, a hydroxy or cyano group or an optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, aralkyl, aryl, alkylamino, alkylthio or alkoxy group; andl represents an integer from 1 to 3.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: April 1, 1997
    Assignee: Shell Research Limited
    Inventor: Waldemar F. A. Pfrengle
  • Patent number: 5606076
    Abstract: The present invention is directed to a process for the synthesis of 2-arylbenzo[b]thiophenes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 25, 1997
    Assignee: Eli Lilly and Company
    Inventors: James A. Aikins, Tony Y. Zhang
  • Patent number: 5556971
    Abstract: A process is provided for preparing isocyanate and isocyanate-based 1,3,5-triazine derivatives by the direct phosgenation of (at least tris-unsubstituted amino)-1,3,5-triazines.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: September 17, 1996
    Assignee: Cytec Technology Corp.
    Inventors: William E. Bay, William F. Jacobs, III, David Gschneidner, Ram B. Gupta