Patent number: 6503919
Abstract: A compound selected from those of formula (I):
wherein:
X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy,
R1 represents hydrogen, or alkyl,
R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted amino,
R3 and R4 represent hydrogen, or alkyl,
R5 and R6 represent —O—CO—U—V wherein U and V are as defined in the description, or Z as defined in the description, it being understood that at least one of the R5 and R6 groups represents —O—CO—U—V,
their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of cancer.
Type:
Grant
Filed:
June 15, 2000
Date of Patent:
January 7, 2003
Assignee:
Les Laboratoires Server
Inventors:
Michel Koch, François Tillequin, Sylvie Michel, Ghanem Atassi, Alain Pierre, Pierre Renard, Bruno Pfeiffer
Patent number: 6288073
Abstract: A compound selected from those of formula (I):
in which:
X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy,
R1 represents hydrogen, or alkyl,
R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted ammo,
R3 and R4 represent hydrogen, or alkyl,
A represents —CH═CH—, or —CH(R5)—CH(R6)— wherein R5 and R6 are as defined in the description,
their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof,
and medicinal products containing the same which are useful in the treatment of cancer.
Type:
Grant
Filed:
June 19, 2000
Date of Patent:
September 11, 2001
Assignee:
Adir et Compagnie
Inventors:
Michel Koch, François Tillequin, Sylvie Michel, Ghanem Atassi, Alain Pierre, Bruno Pfeiffer, Pierre Renard
Patent number: 6020341
Abstract: A quinone imine enediyne possessing cytotoxic activity towards cancer cells having general structure (I) wherein R.sub.1, R.sub.2 and R.sub.3 are independently the same or different and are H, Br, Cl, F, NH.sub.2, CO.sub.2 H, OH, linear or branched alkyl, etc.; wherein R.sub.4 is H, OH or linear or branched alkoxy, linear or branched alkoxycarbonyl, etc.; wherein R.sub.5 is H, Br, Cl, F, O.dbd., OH or S--SR, or linear or branched alkyl, etc.; wherein R.sub.6 is H, Br, Cl, F, CO.sub.2 H, OH or S--SR', or linear or branched alkyl, etc.; wherein R.sub.7 is H, OH or S--SR", or linear or branched alkyl, linear or branched alkoxycarbonyl, linear or branched alkoxy or linear or branched hydroxyalkyl; and wherein R, R' and R" are independently the same or different and are linear or branched alkyl, linear or branched acyl or linear or branched alkoxyalkyl.
Type:
Grant
Filed:
October 16, 1997
Date of Patent:
February 1, 2000
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Matthew D. Shair, Taeyoung Yoon, Ting-Chao Chou, Karoline K. Mosny