Heavy Metal Or Aluminum Containing Patents (Class 548/101)
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Patent number: 5482955Abstract: New cyclopropyl-ethyl-azoles of the formula ##STR1## in which R represents alkyl, alkenyl, alkinyl, cycloalkyl which is optionally substituted by alkyl, or optionally substituted aryl, optionally substituted aralkyl or optionally substituted aralkenyl, andZ represents a nitrogen atom or a CH group,and addition products thereof with acids or metal salts are very effective for combating fungi.Novel oxiranes of the formula ##STR2## in which R and Z have the abovementioned meanings,are valuable intermediates.Type: GrantFiled: April 4, 1995Date of Patent: January 9, 1996Assignee: Bayer AktiengesellschaftInventors: Manfred Jautelat, Stefan Dutzmann, Klaus Stenzel, Heinz-Wilhelm Dehne
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Patent number: 5462955Abstract: New azolylmethyl-fluorocyclopropyl derivatives of the formula ##STR1## in which R represents ##STR2## and addition products thereof which acids or metal salts are very effective for combating fungi.New oxiranes of the formula ##STR3## in which R has the abovementioned meaning, are valuable intermediates for the preparation of compounds of the formula (I).Type: GrantFiled: February 15, 1994Date of Patent: October 31, 1995Assignee: Bayer AktiengesellschaftInventors: Jurgen Scherkenbeck, Thomas Himmler, Stefan Bohm, Hermann Hagemann, Klaus Stroech, Stefan Dutzmann, Heinz-Wilhelm Dehne, Gerd Hanssler
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Patent number: 5460669Abstract: The energetic salts of 3-nitramino-4-nitrofurazan have a desirable combination of desirable properties such as sufficiently high densities, and low or no hydrogen content. The salts are useful as ingredients in various propellant, explosive, gassifier, and pyrotechnic compositions. 3-Nitramino-4-nitrofurazan is itself a useful energetic compound and is also useful in the synthesis of still further energetic compounds.Type: GrantFiled: June 28, 1993Date of Patent: October 24, 1995Assignee: Thiokol CorporationInventors: Rodney L. Willer, Robert S. Day, Dennis J. Park, deceased
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Patent number: 5409915Abstract: Novel bis(platinum) (IV) complexes coupled via diamine bridging agents are taught as well as methods for their preparation. These complexes are to be used as pharmaceutical agents, e.g., for the treatment of cancer and parasitic diseases.Type: GrantFiled: September 14, 1993Date of Patent: April 25, 1995Assignee: The University of Vermont and State Agricultural CollegeInventors: Nicholas Farrell, Silvano Spinelli, Mariella Valsecchi, Ernesto Menta
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Patent number: 5397768Abstract: Compounds of the formula ##STR1## are fungicides and herbicides when Z is alkyl, cycloalkyl, aryl, or aralkyl; Q is a triazolyl; X is an aryl group or a heterocyclic group; and W is a variety of functional groups.Type: GrantFiled: October 1, 1993Date of Patent: March 14, 1995Assignee: Rohm and Haas CompanyInventors: Steven H. Shaber, Luong T. Nguyen
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Patent number: 5371065Abstract: Fungicidal and plant growth-regulating substituted azolylmethyloxiranes of the formula ##STR1## in which R.sup.1 stands for alkyl,R.sup.2 stands for alkyl,X stands for a nitrogen atom or the CH group,Y stands (or halogen, alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl and/or optionally substituted phenylalkoxy andm stands for the numbers 0, 1, 2 or 3,and addition products thereof with acids and metal salts.Type: GrantFiled: February 2, 1989Date of Patent: December 6, 1994Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Karl H. Buchel, Wilhelm Brandes, Stefan Dutzmann, Klaus Lurssen
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Patent number: 5364870Abstract: This invention relates to novel (2-aryl-2-substituted)ethyl-1,2,4- triazoles and the enantiomorphs, acid addition salts and metal salt complexes thereof, as well as their method of preparation and their use as highly active broad-spectrum systemic fungicides.Type: GrantFiled: September 17, 1993Date of Patent: November 15, 1994Assignee: Rohm and Haas CompanyInventors: Steven H. Shaber, Katherine E. Flynn
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Patent number: 5346927Abstract: Blowing agents of tetrazoles and their derivatives which have a melting point over 200.degree. C. and are used to manufacture the high quality foaming thermoplastic synthetic resin moldings, especially engineering or superengineering plastic moldings and said blowing agents generate no harmful gases and do not cause the deterioration of the thermoplastic synthetic resin moldings.Type: GrantFiled: September 8, 1992Date of Patent: September 13, 1994Assignee: Toyo Kasei Kogyo Company, Ltd.Inventors: Atsuhiro Onishi, Koichi Matsunami, Masanao Ebara, Hiroaki Tanaka
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Patent number: 5334608Abstract: New azolylmethyl-cyclopropyl derivatives of the formula ##STR1## in which R represents cyano or a group of the formula ##STR2## Z represents halogen, alkyl having 1 to 4 carbon atoms, halogenoalkyl having 1 to 4 carbon atoms and 1 to 5 halogen atoms, alkoxy having 1 to 4 carbon atoms, halogenoalkoxy having 1 to 4 carbon atoms and 1 to 5 halogen atoms, or alkoximininoalkyl having 1 to 4 carbon atoms in the alkoxy group and 1 to 4 carbon atoms in the alkyl group andm represents the numbers 0, 1 or 2, and addition products thereof with acids or metal salts are very effective for combating fungi.New oxiranes of the formula ##STR3## in which Z and m have the abovementioned meanings, are valuable intermediates for the preparation of compounds of the formula (I).Type: GrantFiled: February 23, 1993Date of Patent: August 2, 1994Assignee: Bayer AktiengesellschaftInventors: Jurgen Scherkenbeck, Thomas Himmler, Hermann Hagemann, Stefan Dutzmann, Heinz-Wilhelm Dehne, Gerd Hanssler
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Patent number: 5304568Abstract: New ethyl-triazolyl derivatives of the formula ##STR1## in which R represents halogen,X.sup.1 represents fluorine, chlorine or bromine,X.sup.2 represents fluorine, chlorine or bromine,Z represents halogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, ethyl having 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy having 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl, phenoxy, nitro or alkoximinoalkyl having 1 to 4 carbon atoms in the alkoxy moiety and 1 to 4 carbon atoms in the alkyl moiety andm represents the numbers 0, 1, 2 or 3,and addition products thereof with acids or metal salts are very effective for combating fungi.Novel ethyl-triazolyl derivatives of the formula ##STR2## in which R, Z and m have the abovementioned meanings,and addition products thereof with acids or metal salts are very effective for combating fungi.Type: GrantFiled: August 6, 1993Date of Patent: April 19, 1994Assignee: Bayer AktiengesellschaftInventors: Jurgen Scherkenbeck, Michael Lindemann, Stefan Dutzmann, Heinz-Wilhelm Dehne
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Patent number: 5298624Abstract: Stable, organometallic complexes of 5,5-diphenyl-2,4 imidazolidenedione (diphenyl hydantoin) are versatile biocides, effective when applied topically or parenterally to animal tissue, and when applied topically to plants. The diphenyl Hydantoin complexes are seen to prevent animal and plant tissue infections, and may be combined with other materials to inhibit infection.Type: GrantFiled: November 12, 1992Date of Patent: March 29, 1994Inventor: Sigmund E. Lasker
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Patent number: 5298623Abstract: This invention describes Cu complexes of bis-oxazolines and their use. These compounds have the following formulas: ##STR1##This project is supported in part by N. I. H. grant GM-35879.Type: GrantFiled: November 8, 1991Date of Patent: March 29, 1994Assignee: Massachusetts Institute of TechnologyInventors: Satoru Masamune, Richard E. Lowenthal
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Patent number: 5294634Abstract: The present invention relates to an orally-administrable osteogenesis promoter, which comprises, as an active ingredient, a zinc salt or complex of L-carnosine, has excellent osteogenesis-accelerating action, and is extremely low in toxicity and side effects.Type: GrantFiled: April 2, 1992Date of Patent: March 15, 1994Assignees: Zeria Pharmaceutical Co., Ltd., Hamari Chemicals Co., Ltd.Inventor: Masayoshi Yamaguchi
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Patent number: 5272130Abstract: A compound having the formula: ##STR1## and stereoisomers thereof, wherein R.sup.1 is --CH.dbd.CH--X or --C.tbd.C--X where X is hydrogen or straight chain alkyl; R.sup.2 is halophenyl, Z is OR.sup.3 where R.sup.3 is H, alkyl, alkenyl or alkynyl; and acid addition salts and metal complexes thereof. These compounds have fungicidal and plant growth regulating properties. Intermediates for these compounds are also disclosed.Type: GrantFiled: May 10, 1989Date of Patent: December 21, 1993Assignee: Imperial Chemical Industries PLCInventors: Robert A. Noon, Patrick J. Crowley, Diana M. Worthington
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Patent number: 5266586Abstract: Fungicidal trazoles of the formula ##STR1## in which Ar stands for optionally substituted aryl,A stands for the groups ##STR2## and X stands for the groups ##STR3## wherein R.sup.1 stands for hydrogen or alkyl,R.sup.2 stands for hydrogen or alkyl,R.sup.3 stands for hydrogen, alkyl, alkenyl, alkanoyl, for optionally substituted cycloalkyl or for in each case optionally substituted aralkyl or aroyl,R.sup.4 stands for hydrogen, alkyl, for optionally substituted cycloalkyl or for in each case optionally substituted aralkyl or aryl andR.sup.5 and R.sup.6 independently of one another stand for alkyl or for optionally substituted aralkyl or together stand for an optionally substituted doubly-linked alkylene radical,and addition products thereof with acids and metal salts.Type: GrantFiled: May 14, 1992Date of Patent: November 30, 1993Assignee: Bayer AktiengesellschaftInventors: Gerd Kleefeld, Stefan Dutzmann
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Patent number: 5266584Abstract: New Ethyl-triazolyl derivatives of the formula ##STR1## in which R represents halogen,X.sup.1 represents fluorine, chlorine or bromine,X.sup.2 represents fluorine, chlorine or bromine,Z represents halogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, ethyl having 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy having 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl, phenoxy, nitro or alkoximinoalkyl having 1 to 4 carbon atoms in the alkoxy moiety and 1 to 4 carbon atoms in the alkyl moiety andm represents the numbers 0, 1, 2 or 3,and addition products thereof with acids or metal salts are very effective for combating fungi.Type: GrantFiled: April 2, 1993Date of Patent: November 30, 1993Assignee: Bayer AktiengesellschaftInventors: Jurgen Scherkenbeck, Michael Lindemann, Stefan Dutzmann, Heinz-Wilhelm Dehne
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Patent number: 5262543Abstract: The present invention discloses a process to produce a compound of the formula (IA): ##STR1## or an acid addition salt or metal complex thereof, in which n represents an integer from 0 to 5; each R represents a halogen atom, or a nitro, cyano, alkyl, haloalkyl or phenyl group; R.sup.1 and R.sup.2 independently represent a hydrogen atom or an alkyl group; and A represents a nitrogen atom or a CH group; which comprises steps of:(1) reacting a compound of the formula (IVA): ##STR2## with a compound of the formula (V): R.sup.3 SO.sub.2 X (V) in which n, R, R.sup.1 and R.sup.2 are as defined above and R.sup.3 represents a C.sub.1-4 alkyl group or a phenyl group each optionally substituted by one or more substituents selected from halogen atoms, nitro, cyano, hydroxyl, C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkoxy; amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, C.sub.1-4 alkoxycarbonyl, carboxyl, C.sub.1-4 alkanoyl, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphinyl, C.sub.Type: GrantFiled: June 3, 1992Date of Patent: November 16, 1993Assignee: Kureha Kagaku Kogyu Kabushiki KaishaInventor: Paul H. Briner
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Patent number: 5262434Abstract: New halogenoalkyl-azolyl derivatives of the formula ##STR1## in which R.sup.1 represents optionally substituted phenyl,R.sup.2 represents hydrogen, alkyl, alkenyl, acyl or aralkyl,X.sup.1 represents halogen,X.sup.2 represents halogen,n represents 0 or 1 andY represents nitrogen or a CH groupand their acid addition salts and metal salt complexes, are outstandingly effective as microbicides in plant protection and in the preservation of materials.Type: GrantFiled: August 14, 1992Date of Patent: November 16, 1993Assignee: Bayer AktiengesellschaftInventors: Manfred Jautelat, Jurgen Scherkenbeck, Klaus Stroech, Stefan Dutzmann, Heinz Dehne, Gerd Haenssler, Karl-Heinz Kuck
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Patent number: 5252317Abstract: Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each comprising plural active groups, such as stable nitroxides and complexes of trivalent metal cations. Such syntheses were successfully performed using a number of amplifiers having different branched structures, demonstrating the general utility of the pertinent chemistry in the synthesis of amplifiers having any of a wide variety of pharmacologically active groups. Amplifiers were also synthesized having linkers terminating with chemically reactive groups such as isothiocyanates, which render the amplifier bifunctional: attachable to polymers, biomacromolecules, or other biocompatible entity possessing multiple reactive sites such as terminal amines.Type: GrantFiled: May 22, 1992Date of Patent: October 12, 1993Assignee: The State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of OregonInventor: John F. W. Keana
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Patent number: 5252594Abstract: This invention relates to novel (2-aryl-2-substituted)ethyl-1,2,4-triazoles and the enantiomorphs, acid addition salts and metal salt complexes thereof, as well as their method of preparation and their use as highly active broad-spectrum systemic fungicides.Type: GrantFiled: June 17, 1992Date of Patent: October 12, 1993Assignee: Rohm and Haas CompanyInventors: Steven H. Shaber, Katherine E. Flynn
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Patent number: 5250555Abstract: 1-Halo-1-azolylmethane derivatives of the formula ##STR1## where A and R are each alkyl, benzyl, benzoyl, acyl, biphenylyl, naphthyl, hetaryl or phenyl, it being possible for each of these radicals to be substituted;D is Cl or Br,X is CH or N,and their plant-compatible acid addition salts and metal complexes are used as fungicides.Type: GrantFiled: September 23, 1991Date of Patent: October 5, 1993Assignee: BASF AktiengesellschaftInventors: Rainer Seele, Norbert Goetz, Thomas Saupe, Gisela Lorenz, Eberhard Ammermann
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Patent number: 5248683Abstract: Compounds of the formula ##STR1## in which A.sub.1 and A.sub.2 independently of one another are CO--C.sub.1 -C.sub.4 alkyl, COO--C.sub.1 -C.sub.4 alkyl, CO--CF.sub.3, CO--N(R).sub.2 or cyano;A.sub.1 and A.sub.2 together are CO(X).sub.n --C.sub.1 -C.sub.3 alkylene-(X).sub.n CO, CO(X).sub.n --C.sub.1 -C.sub.3 alkylene-(X).sub.n CO which is substituted by C.sub.1 -C.sub.4 alkyl, COOR, CON(R).sub.2, cyano or phenyl, it being possible for the phenyl ring, in turn, to be substituted by halogen, methyl, trifluoromethyl, methoxy, nitro or cyano; CO--N(R)--CO--N(R)--CO;R is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 alkynyl;X is oxygen, sulfur or N(CH.sub.3);X.sub.1, X.sub.2 and X.sub.3 independently of one another are hydrogen, halogen, methyl, methylthio, methoxy or nitro;n is 0 or 1;including the salts of the compounds of the formula I with agriculturally acceptable organic or inorganic bases, and including the metal complexes; have valuable microbicidal properties.Type: GrantFiled: June 4, 1992Date of Patent: September 28, 1993Assignee: Ciba-Geigy CorporationInventors: Hans-Georg Brunner, Walter Kunz, Rolf Schurter
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Patent number: 5238808Abstract: A chemical moiety is disclosed which comprises a chemical, biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmium-containing luminescent organometallic compounds. Methods are disclosed for detecting very small amounts of the chemical moiety using chemiluminescent, electrochemiluminescent, and photoluminescent means. Compounds are disclosed which are useful for labelling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labelled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labelled substances are of particular use in homogeneous binding assays.Type: GrantFiled: October 24, 1985Date of Patent: August 24, 1993Assignee: Igen, Inc.Inventors: Allen J. Bard, George M. Whitesides
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Patent number: 5221605Abstract: A chemical moiety is disclosed which comprises a chemical biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmiumcontaining luminescent organometallic compounds. Methods are disclosed for detecting very small amounts of the chemical moiety using chemiluminescent, electrochemiluminescent, and photoluminescent means. Compounds are disclosed which are useful for labelling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labelled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labelled substances are of particular use in homogeneous binding assays.Type: GrantFiled: October 30, 1990Date of Patent: June 22, 1993Assignee: Igen, Inc.Inventors: Allen J. Bard, George M. Whitesides
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Patent number: 5220021Abstract: Unsaturated geminal phosphonates (III) ##STR1## either as the esters, free acids or salts are useful in the treatment of arthritis.Type: GrantFiled: September 6, 1991Date of Patent: June 15, 1993Assignee: The Upjohn CompanyInventors: Colin J. Dunn, Richard A. Nugen
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Patent number: 5219876Abstract: The invention provides compounds of formula I wherein R, R.sub.1 and Az are as defined in the description, the fungicidal use of such compounds, compositions for facilitating such use and the preparation of compounds of formula I.Type: GrantFiled: April 6, 1992Date of Patent: June 15, 1993Assignee: Sandoz Ltd.Inventor: Rupert Schneider
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Patent number: 5216006Abstract: Fungicidal azolyl-propanols of the formula ##STR1## in which R represents halogenoalkyl, halogenoalkenyl, a 2-phenoxy-isopropyl radical, ##STR2## Y represents nitrogen or a CH group, Z represents halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, cyano, phenoxy, halo-phenoxy, or optionally substituted aryl,m represents the number 0, 1, 2, or 3, and addition products thereof with acids and metal salts.Type: GrantFiled: June 3, 1991Date of Patent: June 1, 1993Assignee: Bayer AktiengesellschaftInventors: Je,uml/u/ rgen Scherkenbeck, Thomas Himmler, Klaus Stroech, Stefan Dutzmann, Gerd Hanssler, Heinz-Wilhelm Dehne
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Patent number: 5216010Abstract: N-Thiocyanatomethoxyazaheterocycles of the general formula INCS--CH.sub.2 --O--Het(where Het is pyrazolyl, imidazolyl or triazolyl, each of which may be substituted, or is indazolyl, benzoimidazolyl or benzotriazolyl, where each of the fused benzene rings may furthermore be substituted, and the salts and metal complexes thereof, with the exception of 1-[(thiocyanato)methoxy]-pyrazole, and biocides containing them.Type: GrantFiled: April 29, 1991Date of Patent: June 1, 1993Assignee: BASF AktiengesellschaftInventors: Wolfgang Reuther, Ulf Baus, Gisela Lorenz
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Patent number: 5216007Abstract: This invention relates to substituted ethylenic imidazoles and triazoles, their enantiomorphs, acid addition salts and metal complexes as well as their methods of preparation and use as broad spectrum systemic fungicides useful in controlling phytopathogenic fungi such as barley net blotch (Helminthosporium teres), bean powdery mildew (Erysiphe polygoni), peanut cercospora (Cercospora arachidicola), and wheat stem rust (Puccinia graminis f. sp. tritici race 15B-2).Type: GrantFiled: January 15, 1992Date of Patent: June 1, 1993Assignee: Rohm and Haas CompanyInventors: George A. Miller, Hak-Foon Chan
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Patent number: 5206232Abstract: The present invention concerns improved crystalline metal complexes of the fungicide 1-[N-propyl-N-2-(2,4,6-trichlorophenoxy)-ethyl carbamoyl]-imidazole, known by the common name prochloraz, its improved formulations and their use in combatting fungi, especially powdery mildew (Sphaerotheca fuliginia) and coffee berry disease (Colletotrichum coffeanum).Type: GrantFiled: March 1, 1991Date of Patent: April 27, 1993Assignee: Makhteshim Chemical Works Ltd.Inventors: Joseph Sharvit, Daniel Shohat, Yosef Gur
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Patent number: 5204362Abstract: Azolylethane derivatives of the formula I ##STR1## where A and R.sup.1 are each alkyl, phenyl, biphenyl, naphthyl, benzyl, cycloalkyl, alkoxy, alkylthio, phenoxy, benzyloxy, phenylthio, methoxycarbonylethyl or hetaryl, these radicals being substituted or unsubstituted,D is halogen, alkoxy, alkylthio, phenylthio or phenoxy, these radicals being substituted or unsubstituted,X is CH or N,plant-tolerated acid addition salts and metal complex compounds thereof, and fungicides containing these compounds.Type: GrantFiled: March 26, 1991Date of Patent: April 20, 1993Assignee: BASF AktiengesellschaftInventors: Rainer Seele, Norbert Goetz, Wolfgang Brox, Reiner Kober, Eberhard Ammermann, Gisela Lorenz
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Patent number: 5204363Abstract: Triazole and imidazole compounds having the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl, optionally substituted cycloalkyl, cycloalkylmethyl, alkenyl, heterocyclyl, aryl or aralkyl optionally substituted with halogen, nitro alkyl, haloalkyl, haloalkoxy, alkoxy, phenyl, phenoxy, benzyl, benzylosy, halophenyl or haloalkoxy; R.sup.3 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl or acyl; R.sup.4 and R.sup.5, which may be the same or different, are hydrogen, alkyl, alkenyl or optionally substituted aryl; R.sup.6 and R.sup.7, which may be the same or different, are hydrogen, alkyl, alkenyl or optionally substituted aryl; X is oxygen or sulphur or is SO or SO.sub.2 ; and Az is 1,2,4- or 1,3,4-triazole or imidiazole ring; and isomers, acid addition salts and metal complexes thereof. The compounds are useful as plant fungicides.Type: GrantFiled: January 18, 1991Date of Patent: April 20, 1993Assignee: Imperial Chemical Industries PLCInventors: Balasubramanyan Sugavanam, Paul A. Worthington, John M. Clough
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Patent number: 5194444Abstract: Azolylmethyloxiranes of the general formula I ##STR1## where A and B are cycloalkyl, tetrahydropyranyl, tetrahydrofuranyl, dioxanyl, norbornyl, cycloalkenyl or phenyl, each of these radicals being unsubstituted or substituted, with the proviso that A and Z are not simultaneously phenyl, D is O, X is CH or N, and their plant-tolerated acid addition salts or metal complexes, and fungicides containing these compounds.Type: GrantFiled: February 11, 1992Date of Patent: March 16, 1993Assignee: BASF AktiengesellschaftInventors: Rainer Seele, Stefan Karbach, Thomas Kuekenhoehner, Hubert Sauter, Gisela Lorenz, Eberhard Ammermann
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Patent number: 5194626Abstract: Metal complexes of azines of the formula ##STR1## in which X denotes hydrogen or halogen,R denotes hydrogen or an organic radical,R.sub.1 denotes hydrogen or an organic radical,R.sub.2 denotes an organic radical, in which R.sub.1 and R.sub.2 together with the C atom linking them can also form a carbocyclic or heterocyclic ring or a carbocyclic or heterocyclic ring system in which the rings and ring systems mentioned can also be substituted, and one of the radicals R.sub.1, R.sub.2 or R.sub.1 and R.sub.2 together contain a group capable of forming a metal salt, and processes for pigmenting using these metal complexes.Type: GrantFiled: January 17, 1992Date of Patent: March 16, 1993Assignee: Bayer AktiengesellschaftInventors: Meinhard Rolf, Bernd Kaletta
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Patent number: 5192783Abstract: This invention relates to 1 and 4-aralkyl-1,2,4-triazoles, their enantiomorphs, acid addition salts and metal salt complexes. This invention also relates to the method of preparation and use of these compounds. These compounds are highly active broad-spectrum systemic fungicides effective in controlling phytopathogenic fungi such as barley net blotch (Helminthosporium teres), grey mold (Botrytis cinerea), bean powdery mildew (Erysiphe polygoni), grape downy mildew (Plasmopora viticola), rice blast (Piricularia oryzae), tomato late blight (Phytophthora infestans) and wheat stem rust (Puccinia graminis f. sp. tritici race 15B-2).Type: GrantFiled: September 30, 1985Date of Patent: March 9, 1993Assignee: Rohm and Haas CompanyInventors: George A. Miller, Hak-Foon Chan, Hak-Foon Chan
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Patent number: 5190565Abstract: A new class of sulfonated 2-(2'-hydroxyaryl)-2H-benzotriazole compounds and method for using them and other sulfonated hydroxyaryl benzotriazoles on nylon fibers to improve stain resistance and dye lightfastness has been discovered. A process is provided for improving stain resistance of nylon fibers by treatment with sulfonated aromatic-formaldehyde condensate and fluorinated dry soil resist agents.Type: GrantFiled: February 1, 1991Date of Patent: March 2, 1993Assignee: Allied-Signal Inc.Inventors: Morris B. Berenbaum, John H. Bonfield, Charles J. Cole, Paul W. Harris, Thomas P. J. Izod, Harry E. Ulmer, Frederick R. Hopf, James T. Yardley, Karen M. Bland
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Patent number: 5187178Abstract: Fungicidal triazoles of the formula ##STR1## in which Ar stands for optionally substituted aryl,A stands for the groups ##STR2## and X stands for the groups ##STR3## wherein R.sup.1 stands for hydrogen or alkyl,R.sup.2 stands for hydrogen or alkyl,R.sup.3 stands for hydrogen, alkyl, alkenyl, alkanoyl, for optionally substituted cycloalkyl or for in each case optionally substituted aralkyl or aroyl,R.sup.4 stands for hydrogen, alkyl, for optionally substituted cycloalkyl or for in each case optionally substituted aralkyl or aryl andR.sup.5 and R.sup.6 independently of one another stand for alkyl or for optionally substituted aralkyl or together stand for an optionally substituted doubly-linked alkylene radical,and addition products thereof with acids and metal salts.Type: GrantFiled: April 17, 1991Date of Patent: February 16, 1993Assignee: Bayer AktiengesellschaftInventors: Gerd Kleefeld, Stefan Dutzmann
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Patent number: 5187172Abstract: Compounds having a 5 membered, nitrogen containing ring with a thione group adjacent to a nitrogen atom substituted with an OR group have antimicrobial properties. Metal complexes or salts of these compounds also have antimicrobial properties. The compounds, or the metal complexes or salts thereof, can be used as a cutting fluid preservative, a wood preservative, in cooling water applications or as an antimicrobial agent in a paint. Some of the compounds are new. The metal complexes or salts are new.Type: GrantFiled: February 18, 1992Date of Patent: February 16, 1993Assignee: Imperial Chemical Industries PLCInventor: Peter W. Austin
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Patent number: 5175169Abstract: New halogenovinyl-azole derivatives of the formula ##STR1## in which R.sup.1 represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl or optionally substituted aryl, or represents optionally substituted heteroaryl,R.sup.2 represents hydrogen, alkyl, alkenyl, acyl or aralkylX.sup.1 represents halogen,X.sup.2 represents halogen,X.sup.3 represents hydrogen or halogenY represents nitrogen or a CH group,and acid addition salts and metal salt complexes thereofare very effective for combating microbes in plant protection and in the preservation of materials.Type: GrantFiled: September 17, 1991Date of Patent: December 29, 1992Assignee: Bayer AktiengesellschaftInventors: Manfred Jautelat, Dieter Berg, Stefan Dutzmann, Wilhelm Brandes, Gerd Hanssler, Astrid Mauler, Wilfried Paulus, Monika Frie
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Patent number: 5175311Abstract: A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands includes two complexing atoms each complexed to one of the metal atoms. At least one of the bridging ligands includes a chiral center which is bonded to one of the complexing atoms. Preferably, all four of the bridging ligands include a chiral center bonded to one of the complexing atoms. The catalyst of the invention has been found to be useful in catalyzing carbenoid transformation reactions such as cyclopropanation.Type: GrantFiled: March 29, 1990Date of Patent: December 29, 1992Assignee: Research Corporation Technologies, Inc.Inventor: Michael F. Doyle
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Patent number: 5171748Abstract: The invention concerns novel heterocyclic compounds of the formula I as defined herein and their physiologically acceptable salts, together with pharmaceutical compositions containing them. The heterocyclic compounds antagonize the actions of angiotensin II and are of value in treating diseases or medical conditions such as hypertension and congestive heart failure in warm-blooded animals. The invention further includes processes for the manufacture of the novel compounds and their use in medical treatment.Type: GrantFiled: May 22, 1990Date of Patent: December 15, 1992Assignee: Imperial Chemical Industries plcInventors: David A. Roberts, Simon T. Russell
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Patent number: 5164408Abstract: 1,2-Dihaloazolylethane derivatives of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each substituted or unsubstituted phenyl, biphenyl, naphthyl or hetaryl, Z is chlorine or bromine, and X is CH or N, and their plant-tolerated acid addition salts and metal complexes, and fungicides and growth regulators containing these compounds.Type: GrantFiled: July 13, 1990Date of Patent: November 17, 1992Assignee: BASF AktiengesellschaftInventors: Rainer Seele, Norbert Goetz, Walter Himmele, Reiner Kober, Wolfgang Rohr, Eberhard Ammermann, Gisela Lorenz, Wilhelm Rademacher, Johann Jung
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Patent number: 5162357Abstract: and their acid addition salts and metal complexes,with the exception of 2-(imidazol-1-ylmethyl)-2-(4-fluorophenyl)-3-(pyrid-3-yl)-oxirane.The compounds I are suitable as fungicides.Type: GrantFiled: September 7, 1990Date of Patent: November 10, 1992Assignee: BASF AktiengesellschaftInventors: Rainer Seele, Norbert Goetz, Reiner Kober, Bernhard Zipperer, Eberhard Ammermann, Gisela Lorenz, Joachim Gebhardt
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Patent number: 5162358Abstract: New halogenoalkyl-azolyl derivatives of the formula ##STR1## in which R.sup.1 represents optionally substituted alkyl, optionally substituted alkenyl or optionally substituted cycloalkyl,R.sup.2 represents hydrogen, alkyl, alkenyl, acyl or aralkyl,X.sup.1 represents halogen,X.sup.2 represents halogen,n represents 0 or 1 andY represents nitrogen or a CH group,and acid addition salts and metal salt complexes thereofare very effective for combating undesired microorganisms in plant protection and in the preservation of materials.Type: GrantFiled: July 30, 1991Date of Patent: November 10, 1992Assignee: Bayer AktiengesellschaftInventors: Manfred Jautelat, Jurgen Scherkenbeck, Klaus Stroech, Stefan Dutzmann, Heinz-Wilhelm Dehne, Gerd Hanssler, Harl-Heinz Kuck
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Patent number: 5160527Abstract: A composition comprising:(a) A 3-isothiazolone compound(b) a stabilizing amount of a metal salt, said metal salts selected from the group where the cation is copper, zinc, manganese, ferrous or ferric, and the anion is selected from the group consisting of an organic carboxylic acid of at least of six carbon atoms, EDTA, 8-hydroxyquinolinate, gluconate, o-phenanthroline, quinolinate, N,N-bis(2-hydroxy-5-sulfobenzyl) glycine, lignosulfonate polymers, and polyacrylates; and(c) a locus to be protected against the growth of algae, bacteria, or fungi, selected from the group consisting of:(i) a metal working fluid (MWF) comprising at least one component selected from the group consisting of an alkanolamine, a petroleum sulfonate emulsifier, a boric acid ester or boric acid amide, a corrosion inhibitor, and a fatty acid;(ii) cooling tower water comprising corrosion inhibitors or scale inhibitors,(iii) laundry dish water;(iv) a cosmetic formulation;(v) a fuel system;(vi) an emulsion;(vii) a solid protective or decorType: GrantFiled: May 24, 1991Date of Patent: November 3, 1992Assignee: Rohm and Haas CompanyInventors: Andrew B. Law, Gary L. Willingham
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Patent number: 5143932Abstract: Microbicidal halogenoallyl-azolyl derivatives of the formula ##STR1## in which R.sup.1 represents a radical of the formula ##STR2## R.sup.2 represents hydrogen, alkyl, alkenyl, acyl or aralkyl, X.sup.1 represents halogen,X.sup.2 represents halogen,X.sup.3 represents hydrogen or halogen andY represents nitrogen or a CH group,and addition products thereof with acids and metal salts.Type: GrantFiled: January 25, 1991Date of Patent: September 1, 1992Assignee: Bayer AktiengesellschaftInventors: Manfred Jautelat, Klaus Stroech, Gerd Hanssler, Stefan Dutzmann, Karl-Heinz Kuck, Wilhelm Brandes
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Patent number: 5142061Abstract: The present invention discloses a process to produce a compound of the formula (IA): ##STR1## or an acid addition salt or metal complex thereof, in which n represents an integer from 0 to 5; each R represents a halogen atom, or a nitro, cyano, alkyl, haloalkyl or phenyl group; R.sup.1 and R.sup.2 independently represent a hydrogen atom or an alkyl group; and A represents a nitrogen atom or a CH group; which comprises steps of:(1-a) reacting a compound of the formula (VI): ##STR2## in which n,R,R.sup.1 and R.sup.2 are as defined above, with a reducing agent to obtain a compound of the formula (IVA); or, as an alternative step,(1-b) reacting a compound of the formula (VII): ##STR3## in which n, R,R.sup.1 and R.sup.2 are as defined above and R.sup.5 represents a hydrogen atom or an alkyl group,with a reducing agent to obtain a compound of the formula (IVA);(2) reacting a compound of the formula (IVA): ##STR4## with a compound of the formula (V):R.sup.3 SO.sub.2 X (V)in which n,R,R.sup.1 and R.sup.Type: GrantFiled: October 1, 1990Date of Patent: August 25, 1992Assignee: Kureha Kagaku Kabushiki KaishaInventor: Paul H. Briner
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Patent number: 5140035Abstract: Fungicidal triazolylmethyl-cyclopropyl derivatives of the formula ##STR1## in which R represents a radical of the formula ##STR2## in which Z represents halogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, alkylthio having 1 to 4 carbon atoms, halogenoalkyl having 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy having 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkylthio having 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl which is optionally substituted by at least one of alkyl having 1 or 2 carbon atoms and halogen, or represents phenoxy which is optionally substituted by at least one of alkyl having 1 or 2 carbon atoms and halogen, andm represents the numbers 0, 1, 2 or 3,R.sup.1 represents halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms,n represents the numbers 0, 1 or 2,R.sup.Type: GrantFiled: December 17, 1990Date of Patent: August 18, 1992Assignee: Bayer AktiengesellschaftInventors: Jurgen Scherkenbeck, Klaus Stroech, Burghard Fugmann, Stefan Dutzmann
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Patent number: 5135825Abstract: There is disclosed a method for producing an ambient temperature molten salt comprising at least one of 1,3-dialkylimidazolium halide, 1,2,3-trialkylimidazolium halide and N-alkylpyridinium halide, and an aluminum halide, which comprises suspending the above starting materials in an inert solvent having a low boiling point to carry out a complex forming reaction.Type: GrantFiled: June 15, 1990Date of Patent: August 4, 1992Assignees: Mitsubishi Petrochemical Co., Ltd., Nisshin Steel Co., Ltd.Inventors: Shoichiro Mori, Kazuhiko Ida, Hitoshi Suzuki, Setsuko Takahashi, Isao Saeki
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Patent number: 5135737Abstract: Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each comprising plural active groups, such as stable nitroxides and complexes of trivalent metal cations. Such syntheses were successfully performed using a number of amplifiers having different branched structures, demonstrating the general utility of the pertinent chemistry in the synthesis of amplifiers having any of a wide variety of pharmacologically active groups. Amplifiers were also synthesized having linkers terminating with chemically reactive groups such as isothiocyanates, which render the amplifier bifunctional: attachable to polymers, biomacromolecules, or other biocompatible entity possessing multiple reactive sites such as terminal amines.Type: GrantFiled: September 5, 1989Date of Patent: August 4, 1992Assignee: The State of Oregon Acting by and through the State Board of Higher Education on behalf of the University of OregonInventor: John F. W. Keana