Glucose Patents (Class 600/316)
  • Patent number: 10668214
    Abstract: An integrated circuit includes circuitry to control a process. The process includes adjusting fuzzy-logic control parameters based on received and retrieved blood glucose-related data, predicting blood glucose levels based on the received blood-glucose-related data, and generating control signals to control dispensing of insulin based on the received blood glucose-related data and the fuzzy-logic control parameters. The process may include predicting blood glucose levels based on the retrieved blood glucose-related data. The process may include transitioning between a post-meal correction protocol and a fasting protocol. The process may include transitioning from a post-meal correction protocol to a fasting protocol when a fasting criteria is satisfied.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: June 2, 2020
    Assignee: DOSE SAFETY
    Inventors: Robert C. Kircher, Jr., Richard S. Mauseth, Jason N. Bishop, Donald P. Matheson, Suray Bhatia, Jeff A. Bilmes
  • Patent number: 10653343
    Abstract: A method for noninvasively measuring blood concentration of a substance, such as, for example, blood glucose levels, is described herein. The method may comprise measuring an initial absorption data using near infrared spectroscopy (NIR), and obtaining a second set of absorption data. The initial absorption data, along with the second set of absorption data, may then be adjusted by applying a convolution function and a Monte Carlo simulation to the raw data. In a step, an initial estimate of the level of the substance in the blood, such as, for example, initial blood glucose level, may be calculated based on the adjusted data and pulse oximetry information using a mixing model equation.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: May 19, 2020
    Assignee: New Jersey Institute of Technology
    Inventor: Atam Dhawan
  • Patent number: 10648840
    Abstract: Aspects of spectrometer secondary reference calibration are described. In one embodiment, a diagnostic measurement for evaluation of an aspect of calibration in spectroscopy is performed. A result of the diagnostic measurement is analyzed to determine a deviation from an expected result. Based on the analysis, a correction algorithm may be applied to the aspect of calibration, in view of the deviation. In some embodiments, a product model diagnostic measurement is also performed for further evaluation of the aspect of calibration. A result of the product model diagnostic measurement is analyzed to determine a product model deviation from an expected result of the product model diagnostic measurement, and a product model correction algorithm is applied, if necessary. According to aspects of the embodiments described herein, using secondary reference standards permits reconstruction of calibration parameters without any need for a master instrument or other forms of calibrated reference instrumentation.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: May 12, 2020
    Assignee: WESTCO SCIENTIFIC INSTRUMENTS, INC.
    Inventor: Jerome J. Workman, Jr.
  • Patent number: 10641704
    Abstract: A method of processing raw measurement data from a tunable diode laser absorption spectroscopy (TDLAS) tool or other spectroscopic instrument is provided that determines what types of noise (electronic or process flow) are present in the measurement. Based on that determination, the noise is reduced by performing a weighted averaging using weights selected according to the dominant type of noise present, or a general case is applied to determine weights where neither noise type is dominant. The method also involves performing continuous spectroscopy measurements with the tool, with the data and weighted averaging being constantly updated. Weighting coefficients may also be adjusted based on similarity or difference between time-adjacent traces.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: May 5, 2020
    Inventors: Daniele Angelosante, Andrew Fahrland, Deran Maas, Manish Gupta
  • Patent number: 10617336
    Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 14, 2020
    Assignee: DexCom, Inc.
    Inventors: Apurv Ullas Kamath, James H. Brauker, Paul V. Goode, Jr., Aarthi Mahalingam, Jack Pryor
  • Patent number: 10610135
    Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 7, 2020
    Assignee: DexCom, Inc.
    Inventors: Apurv Ullas Kamath, James H. Brauker, Paul V. Goode, Jr., Aarthi Mahalingam, Jack Pryor
  • Patent number: 10610137
    Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 7, 2020
    Assignee: DexCom, Inc.
    Inventors: Apurv Ullas Kamath, James H. Brauker, Paul V. Goode, Jr., Aarthi Mahalingam, Jack Pryor
  • Patent number: 10595755
    Abstract: A system for monitoring glucose blood level of a user is disclosed. The system comprising an illumination unit configured for providing coherent optical illumination on a selected inspection region on the user body, a collection unit configured for collecting light returning from the inspection region and generating a plurality of image data pieces associated with speckle patterns in the collected light, and a control unit comprising a processing utility and storage utility comprising pre-stored calibration data, the processing utility is configured for receiving input data on a plurality of image data pieces from the collection unit and for processing said input data for determining correlation functions between different image data pieces and using said correlation functions and said pre-stored calibration data for determining data on glucose blood level of the user.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: March 24, 2020
    Assignee: CONTINUSE BIOMETRICS LTD.
    Inventors: Zeev Zalevsky, Roy Talman, Yevgeny Beiderman, Nisim Nisan Ozana, Javier Garcia
  • Patent number: 10582885
    Abstract: The present invention relates to a device and method for noninvasively determining the hematocrit value of a subject. The device comprises a light source (22, 23) for emitting light onto a skin area of the subject, said light comprising first light at a first wavelength in a first wavelength range between 500 and 1000 nm and second light at a second wavelength in a second wavelength range between 1000 and 2000 nm, a reflection detector (24) for detecting light reflected from said skin area of the subject in response to light illumination by said light source, a transmission detector (25) for detecting light transmitted through said skin area of the subject in response to light illumination by said light source, a processing unit (31) for deriving plethysmography, PPG, signals for said first and second wavelengths from the light detected by said reflection detector (24) and said transmission detector (25), and an analysis unit (32) for determining the hematocrit value of the subject from said PPG signals.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: March 10, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Rick Bezemer
  • Patent number: 10575765
    Abstract: An implantable unit includes fluorescent sensor molecules, each of which includes a binding site for an analyte, a donor fluorophore, and an acceptor fluorophore; and a first light source. An external system includes an external reading unit, which includes a light sensor; and a processor, which is configured to (i) during a first time period: (a) drive the first light source to generate light having a first illumination peak wavelength appropriate for excitation of the donor fluorophore, and (b) receive, from the light sensor, a first measurement of the fluorescent light emitted from the acceptor fluorophore, (ii) during a second time period: (a) drive a second light source to generate light having a second illumination peak wavelength appropriate for direct excitation of the acceptor fluorophore, and (b) receive, from the light sensor, a second measurement of the fluorescent light emitted from the acceptor fluorophore, and (iii) calculate the concentration of the analyte based on the measurements.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: March 3, 2020
    Assignee: GLUSENSE LTD.
    Inventor: Boaz Brill
  • Patent number: 10581531
    Abstract: In one embodiment of the invention, a crew member (172) using a computing device (174) communicates over a wireless link (15) with a film system communication module (176) placed nearby a filming tank (178). The computing device (174) can be a smartphone, tablet or computer. A crew member (180) and/or talent (182) wearing a remote transceiver (184) in the tank communicates over a wireless link (58) through the film system communication module. Additional crew members (186) can also connect to the film system communication module (176) and communicate to any person with a transceiver (184).
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: March 3, 2020
    Assignee: Zonaar Corporation
    Inventors: Stig M. Pedersen, Jon L. Vavrus, Nicholas M. Pedersen
  • Patent number: 10561788
    Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves a control system associated with the infusion device obtaining a first measurement indicative of a physiological condition of the user from a first sensing arrangement, obtaining one or more measurements from a second sensing arrangement indicative of a second condition of the user. The control system classifies the second condition as corresponding to one of a plurality of intensity levels based at least in part on the one or more measurements, and thereafter operates the infusion device to deliver the fluid to the user based on the first measurement of the physiological condition in a manner that is influenced by the intensity level classification.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: February 18, 2020
    Assignee: Medtronic MiniMed, Inc.
    Inventor: Anirban Roy
  • Patent number: 10557793
    Abstract: Variations in a translucent medium are imaged by detecting deflections and/or polarization shifts in a probe beam transmitted through the translucent medium. Deflections and polarization shifts may be detected using a first polarizing filter positioned between a probe beam generator and the translucent medium to polarize the probe beam in a first direction, a beam splitter positioned to receive the probe beam after it has been transmitted through the medium, and a probe beam deflection detector that receives a first split beam and provides a deflection signal associated with refractive index variations in the medium. A second polarizing filter receives a second split beam and polarizes it in a second direction, perpendicular to the first direction. An intensity sensor receives the second split beam, after it has passed through the second polarizing filter, and provides an intensity signal associated with a polarization shift in the medium.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: February 11, 2020
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Ronald A. Barnes, Hope T. Beier, Bennett L. Ibey, Caleb C Roth, Joel N Bixler, Christopher M Valdez
  • Patent number: 10553861
    Abstract: A battery cell having an anode or cathode comprising an acidified metal oxide (“AMO”) material, preferably in monodisperse nanoparticulate form 20 nm or less in size, having a pH<7 when suspended in a 5 wt % aqueous solution and a Hammett function H0>12, at least on its surface.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: February 4, 2020
    Assignee: HHELI, LLC
    Inventors: Paige L. Johnson, Jonathan G. Neff
  • Patent number: 10542919
    Abstract: A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: January 28, 2020
    Assignee: St. Louis Medical Devices, Inc.
    Inventor: Zhi Xu
  • Patent number: 10524669
    Abstract: An apparatus for detecting a physiological condition in a person, comprising input structure for receiving at least two physiological parameters, processing structure for determining, from the received physiological parameters, a result signal indicative of the presence or onset of said physiological condition, and output structure for generating an output indicative of the result signal. The apparatus further comprises storage structure for storing a look-up table comprising a plurality of entries, each entry corresponding to a pre-calculated probability of the presence or onset of said physiological condition, the pre-calculated probabilities being determined by way of a mathematical process from previously monitored physiological parameters; and the processing means is adapted to process the received at least two physiological parameters to identify one of the plurality of entries of the look-up table, and to determine said result signal from the identified entry of the look-up table.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: January 7, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Jette Randlov, Jon Ulrich Hansen, Jens Ulrik Poulsen
  • Patent number: 10485473
    Abstract: A portable sensor for measuring a hydration level of an object in close physical proximity with the sensor includes a portable housing having a total volume of less than about 50 cm3. First circuitry disposed in the housing includes a thermal source, a controller electrically coupled to the thermal source, a temperature sensing element, and a processor coupled to the temperature sensing element. When the object is in close physical proximity with the sensor, the thermal source is energized by the controller with a signal having a known function of time. The object affects a time variation of a temperature of the thermal source, the temperature sensing element senses the affected time variation of the temperature of the thermal source, and the processor determines a hydration level of the object based on a characteristic of the affected time variation of the temperature of the thermal source.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 26, 2019
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Andrew P. Bonifas, Ronald D. Jesme, Nicholas T. Gabriel, Andrew J. Ouderkirk, Erin A. McDowell
  • Patent number: 10478072
    Abstract: Exemplary system, method and computer accessible medium are provided for determining at least one characteristic of a target object located behind or within a medium. For example, it is possible to identify a reference object that is located behind or within the medium. The target object and the reference object can be irradiated via a surface of the medium using at least one electromagnetic wave. At least one acoustic signal provided from an irradiated tissue volume that is responsive to the electromagnetic wave(s) can be measured. Calibration information can be obtained from the acoustic signal measured from the reference object based on at least one known property of the reference object. Then, the characteristic(s) of the target object can be determined based on the calibration information and the acoustic signal from the target object.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 19, 2019
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Li Li, Balachundhar Subramaniam
  • Patent number: 10471207
    Abstract: The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor measurements and reference readings may be used to estimate a relationship between sensor measurements and blood glucose concentration. Such sensor measurements may be weighted according to a decreasing function of uncertainty associated with sensor values.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: November 12, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Desmond Barry Keenan, John J. Mastrototaro
  • Patent number: 10448885
    Abstract: A method of treating a host with a medication, comprising assigning a unique identifier to a host treatment apparatus; assigning a unique identifier to the host; storing the unique host identifier and the unique host treatment apparatus identifier on at least one remote server of a network and associating the unique host identifier and the unique host treatment apparatus identifier on the at least one remote server such that the unique host identifier and the unique host treatment apparatus identifier are exclusively associated to each other; activating the host treatment apparatus; coupling the host medication delivery device to the host; operating the host medication delivery device to deliver the medication contained in the host medication delivery device to the host; and operating the host treatment apparatus such that the host treatment apparatus communicates wirelessly to the at least one remote server an operational status of the host medication delivery device.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: October 22, 2019
    Assignee: Insulet Corporation
    Inventor: Kevin G. Schmid
  • Patent number: 10433778
    Abstract: A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: October 8, 2019
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Barry Colin Crane, Nicholas Paul Barwell, William Paterson, Robert Perkins
  • Patent number: 10426387
    Abstract: A measurement system for measuring blood characteristics includes a controller, an emitter, a sensor, a reference photo sensor, and a mask. The emitter emits light at a plurality of wavelengths from a first side of a blood flow channel to a second side of the blood flow channel. The sensor is provided on the second side of the blood flow channel. The reference photo sensor is provided on the first side of the blood flow channel. The mask is provided on the first side blocking reflected light other than from the light from the emitter to enter the reference photo sensor. The controller compensates measurements from the sensor based upon measurements from the reference photo sensor.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: October 1, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventor: Louis L. Barrett
  • Patent number: 10420470
    Abstract: Provided are apparatuses and methods for detecting biological information. An apparatus for detecting biological information may include a biological signal measurement unit having at least two light emission elements having different light emission angles. The at least two light emission elements may include different types of light sources. The at least two light emission elements may include multiple light sources of the same type, and in this case, an optical element configured to adjust a light emission angle of one of the light sources may be provided. The apparatus for detecting biological information may include a biological signal measurement unit including a light emitting unit having variable light emission angle. The apparatus for detecting biological information may further include a data processor configured to extract and analyze biological information of a subject from data measured by the biological signal measurement unit.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: September 24, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Yongjoo Kwon, Jaemin Kang, Sunkwon Kim
  • Patent number: 10405785
    Abstract: A method for determining a concentration of an analyte in a subject includes irradiating a part of the subject with electromagnetic radiation, wherein a part of the subject comprises biological molecules arranged to absorb the electromagnetic radiation and to emit fluorescence in response. The method also includes measuring fluorescence emitted to obtain data representative of a fluorescence decay. The method further includes processing the data to determine one or more feature points associated with the fluorescence decay and to generate one or more feature vectors based on the one or more feature points, and applying the one or more feature vectors to a regression model for the analyte to determine the concentration of the analyte. Also provided is a system for determining a concentration of an analyte in a subject, as well as a measurement device for facilitating determination of a concentration of an analyte in a subject.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: September 10, 2019
    Assignee: CITY UNIVERSITY OF HONG KONG
    Inventors: Derek Ho, Wenrong Yan, Liping Wei, Yi Tian
  • Patent number: 10405706
    Abstract: A smart toilet having a function of human blood oxygen detection is provided. The smart toilet includes a toilet base and a machine body connected to the toilet base. The machine body is provided with a controller and the following modules which are electrically connected to controller respectively, i.e., human blood oxygen detection module, display or voice prompt module, and power supply module which is used to supply power. After processing, the controller obtains the human blood oxygen saturation value based on the electrical signal transferred from the human blood oxygen detection module. Also, the controller controls the display or voice prompt module to output the human blood oxygen saturation value. The present invention combines the toilet with the human blood oxygen detection, such that it is easy for the user to know about his/her blood oxygen condition in real time.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: September 10, 2019
    Assignee: ZHONGSHAN ANBO HEALTH TECHNOLOGY CO., LTD.
    Inventor: Wenhui Zhou
  • Patent number: 10349873
    Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: July 16, 2019
    Assignee: DexCom, Inc.
    Inventors: Apurv Ullas Kamath, Jacob S. Leach, Ying Li, Daiting Rong, Sean Saint, Peter C. Simpson, Mark C. Brister
  • Patent number: 10314539
    Abstract: Provided are apparatuses for and methods of measuring a biological signal. The biological signal measuring apparatus includes reference point sensors configured to detect signals detected from at least two reference marks on a surface of a subject and a biological signal measuring position detector configured to generate information about a biological signal measuring position based on the signals detected from the at least two reference marks. The biological signal measuring apparatus measures the biological signal according to the information about the biological signal measuring position.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 11, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventor: Juneyoung Lee
  • Patent number: 10278591
    Abstract: Blood glucose measurement methods and apparatuses are provided using multiple body signals. The methods and apparatuses are employed to estimate blood glucose in a noninvasive manner by using a change in the absorbance of glucose according to a blood glucose level and to correct the estimated blood glucose using different types of blood glucose measurement methods. The blood glucose measurement apparatus includes a main body worn on a human body, a first light source provided on an inner surface of the main body, a second light source provided on the inner surface of the main body, a light receiver configured to receive light from the first light source and the second light source, and a calculator configured to calculate a glucose level in blood based on an amount of light received by the light receiver and configured to measure blood glucose.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: May 7, 2019
    Assignee: HUINNO CO., LTD.
    Inventor: Yeong Joon Gil
  • Patent number: 10226181
    Abstract: An object information acquiring apparatus comprises a light irradiation unit configured to irradiate lights having different wavelengths respectively; an acoustic wave receiving unit configured to receive an acoustic wave by each of the lights having different wavelengths respectively, and convert into an electric signal that corresponds to each of the lights having different wavelengths; a characteristic information acquiring unit configured to acquire characteristic distribution related to each position in the object based on the electric signal; a statistics acquiring unit configured to acquire a histogram from the characteristic distribution; and an image information acquiring unit configured to acquire image information causing a display device to display the characteristic distribution in the object and the histogram.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 12, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Takuji Oishi
  • Patent number: 10223769
    Abstract: A display device includes a first storage unit and a display chip. The first storage unit stores first extended display identification data comprising a plurality of first preset parameters. The display chip includes a control unit. The control unit provides at least one second preset parameter to replace a part of the first preset parameters in the first extended display identification data in response to a control signal and thereby generate second extended display identification data. The display chip issues a notification signal to notify the display signal providing device to read the second extended display identification data in response to a generation of the second extended display identification data. The display signal providing device provides a first display signal compatible with the second extended display identification data to the display device after reading the second extended display identification data. An extended display identification data replacement method is also provided.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: March 5, 2019
    Assignees: Qisda (Suzhou) Co., Ltd., Qisda Corporation
    Inventor: Chia-Hsiung Kuo
  • Patent number: 10215642
    Abstract: A system and method for detection of a target object/material includes identifying a polarimetric signal for a plurality of aspect angles. One/two-dimensional Mueller matrix image or one/two-dimensional Stokes vector image can be processed using power spectral analysis, wavelet and fractal analysis for further image, having increased discrimination with reduced false-ratio. In addition, each of the angular polarization states due to their association with a particular aspect angle are then cross-correlated to generate a two-dimensional image that relates the level of correlation with the aspect angle. Finally, the output information, including statistical parameters are fed to the input of a neural-fuzzy network for further optimization and image enhancement.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: February 26, 2019
    Assignee: The University of Akron
    Inventor: George C. Giakos
  • Patent number: 10213126
    Abstract: A system including a detector array configured to receive electromagnetic (EM) radiation from a target object, the detector array having one or more detectors is disclosed. The system also includes a readout integrated circuit and one or more processors. The readout integrated circuit has a circuit comprising a number of detector boundary selection components, each one of the number of detector boundary selection components configured to select or adjust a detector boundary from least one of a sub-column boundary or an adjustable boundary.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: February 26, 2019
    Assignee: Raytheon Company
    Inventors: Matthew D. Chambers, John L. Vampola, Micky Harris
  • Patent number: 10188334
    Abstract: Methods, devices, systems, and computer program products are provided to improve sensitivity calibration of an in vivo analyte sensor and usability of an associated analyte monitoring system. In certain embodiments, methods are provided that improve the user experience of using an analyte monitoring system. Certain embodiments of the present disclosure include features that reduce the amount of calibration or re-calibration performed by the analyte monitoring system. More specifically methods of using a suspect calibration attempt to avoid having to recalibrate by adjusting the calibration or mitigating effects of sensor signal attenuation that caused the calibration attempt to be suspect are provided. Additional features are disclosed.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: January 29, 2019
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Erwin Satrya Budiman, Gary Alan Hayter
  • Patent number: 10159412
    Abstract: The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: December 25, 2018
    Assignee: Cercacor Laboratories, Inc.
    Inventors: Marcelo M. Lamego, Massi Joe E. Kiani, Jeroen Poeze, Cristiano Dalvi, Sean Merritt, Hung Vo, Gregory A. Olsen, Ferdyan Lesmana
  • Patent number: 10155087
    Abstract: A biosensor detects a medication applied to an upper epidermal layer of skin of a user. The biosensor obtains at periodic intervals a concentration level of the medication in the upper epidermal layer of skin and surrounding tissue of the user. The biosensor may also detect the concentration level of the medication in an arterial blood flow of the patient or obtain a concentration level of a substance in the arterial blood flow, wherein the concentration level of the substance correlates to a first concentration level of the medication. The biosensor may determine an absorption rate of the medication in the upper epidermal layer of skin and surrounding tissue and in an arterial blood flow of the patient from the detected concentration levels of the medication obtained at the periodic intervals.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: December 18, 2018
    Assignee: SANMINA CORPORATION
    Inventors: Robert Steven Newberry, Matthew Rodencal
  • Patent number: 10156474
    Abstract: A transmission spectroscopy device can direct light into a sample, and determine properties of the sample based on how much light emerges from the sample. The device can use a cell to contain the sample, so that the size of the cell defines the optical path length traversed by light in the sample. To ensure accuracy in the measurements, it is beneficial to calibrate the device by measuring the size of the cell periodically or as needed. To measure the size of the cell, the device can perform a transmission spectroscopy measurement of a known substance, such as pure water, to produce a measured absorbance spectrum of the known substance. The device can subtract a known absorbance spectrum of the known substance from the measured absorbance spectrum to form an oscillatory fringe pattern. The device can determine the size of the cell from a period of the fringe pattern.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: December 18, 2018
    Assignee: Bentley Instruments, Inc.
    Inventors: Craig Parsons, Henrik Lyder
  • Patent number: 10133065
    Abstract: The present invention relates to a heads up display system for a vehicle interior that includes a light modifying panel configured to cyclically transition between a substantially light transmissive state that facilitates light passage through the light modifying panel and a partially reflective state that facilitates light reflection toward a occupant of a vehicle. The heads up display system also includes a pulsating light source configured to cyclically project an image onto the light modifying panel, and a controller configured to control the pulsating light source and the light modifying panel so that the image is projected onto the light modifying panel while the light modifying panel is in the partially reflective state.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: November 20, 2018
    Assignee: Visteon Global Technologies, Inc.
    Inventors: Andrew K. Ruiter, Lawrence Robert Hamelink
  • Patent number: 10130296
    Abstract: An apparatus for noninvasively measuring a bio-analyte including a metering device configured to obtain at least one of light and electrical information representative of an amount of fibrous protein from skin of a subject; and a processor configured to determine information representative of an amount an analyte present in blood of the subject based on the obtained information representative of an amount of the fibrous protein.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: November 20, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Joonhyung Lee, Sangkyu Kim, Seongho Cho
  • Patent number: 10080842
    Abstract: An integrated circuit includes circuitry to control a process. The process includes adjusting fuzzy-logic control parameters based on received and retrieved blood glucose-related data, predicting blood glucose levels based on the received blood-glucose-related data, and generating control signals to control dispensing of insulin based on the received blood glucose-related data and the fuzzy-logic control parameters. The process may include predicting blood glucose levels based on the retrieved blood glucose-related data. The process may include transitioning between a post-meal correction protocol and a fasting protocol. The process may include transitioning from a post-meal correction protocol to a fasting protocol when a fasting criteria is satisfied.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: September 25, 2018
    Assignee: Dose Safety
    Inventors: Robert C. Kircher, Jr., Richard S. Mauseth, Jason N. Bishop, Donald P. Matheson, Suray Bhatia, Jeff A. Bilmes
  • Patent number: 10076356
    Abstract: A subcutaneous access device has a skin attachment plate coated with an adhesive layer. The skin attachment plate is moveably linked by a retraction mechanism to a needle support with fixedly positioned needles. In the ready-to-use position the skin attachment plate is spaced away from the needle support and covers the fixedly positioned needles. Subcutaneous insertion of the needles is effected by attachment of the skin attachment plate with the adhesive layer to the skin and releasing the retraction mechanism, thus triggering the pulling of the attached skin with high velocity against the tip of the needles.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: September 18, 2018
    Assignee: PharmaSens AG
    Inventors: Paul Hadvary, Hansjorg Tschirky
  • Patent number: 10052497
    Abstract: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in in vivo and in vitro environments).
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: August 21, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, David J. Mishelevich, M. Bret Schneider
  • Patent number: 10028659
    Abstract: A system for measuring and/or monitoring an analyte present in interstitial fluid in skin is provided. The system includes a substrate that may be implanted into the skin and a reader device. The substrate includes a sensor comprising aptamer conjugates and is configured to obtain one or more measurements related to at least one analyte in interstitial fluid. The reader device is configured to detect the analyte in interstitial fluid via interaction with the substrate.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: July 24, 2018
    Assignee: Verily Life Sciences LLC
    Inventors: Jerrod Joseph Schwartz, Jason Donald Thompson, Vikram Singh Bajaj
  • Patent number: 10019783
    Abstract: A test piece analyzer and test piece analyzing method which is compact and capable of analyzing a test piece even when mounted obliquely is provided. The test piece analyzer is configured by a test piece holder 11 that includes a mounting part MP for mounting a test piece provided with reagent pads, and an imaging unit 20, wherein the imaging unit 20 is configured to sequentially image the test piece along the longitudinal direction of the mounting part.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 10, 2018
    Assignee: SYSMEX CORPORATION
    Inventor: Takashi Kusuhara
  • Patent number: 10004398
    Abstract: In various embodiments, a device for determining a condition of an organ of either a human or an animal may be provided. The device may include a first optical source and a second optical source. The device may also include a detector. The device may additionally include a lens system. The device may further include a switching mechanism configured to switch between an optical examination mode and a Raman mode. The lens system during the optical examination mode may be configured to direct a first light emitted from the first optical source. The lens system during the Raman mode may be configured to direct a second light emitted from the second optical source. The lens systems during the Raman mode may be further configured to direct a third light to the detector.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 26, 2018
    Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Quan Liu, Roger Beuerman, Shuo Chen
  • Patent number: 10004399
    Abstract: A spectrometer includes an illuminating section; a receiving section configured to detect radiation reflected from an object including an optically inhomogeneous scattering medium; a hardware section configured to obtain a solution of an inverse problem to reconstruct an absorption spectrum of the optically inhomogeneous scattering medium, wherein the illuminating section includes at least one light-emitting diode source, a radiation spectral curve of which is divided, by at least two spectral filters having different spectral transmission curves, into at least two spectral regions, to form an equivalent radiation spectrum from at least two spectral sources, and wherein the hardware section applies the solution of the inverse problem based on information about a spectral content of the radiation of the illuminating section, a signal obtained in a form of a response from the optically inhomogeneous scattering medium, and a spectral sensitivity curve of the receiving section.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: June 26, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Alexey Grigor'evich Anikanov, Sergey Vasil'evich Afanasyev, Vladislav Vladimirovich Druzhin, Alexander Victorovich Morozov
  • Patent number: 9999728
    Abstract: An electronic controller for an insulin infusion device includes at least one processor device and at least one memory element that cooperate to provide a processor-implemented closed-loop initiation module. The initiation module is operated to obtain a most recent calibration factor for a continuous glucose sensor, the most recent calibration factor representing a first conversion value applicable to convert a first sensor value to a first blood glucose value. The initiation module also obtains a prior calibration factor for the sensor, and calibration timestamp data for the most recent calibration factor and the prior calibration factor. The initiation module regulates entry into a closed-loop operating mode of the insulin infusion device, based on the most recent calibration factor, the prior calibration factor, and the calibration timestamp data.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: June 19, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Neha J. Parikh, Anirban Roy, Desmond Barry Keenan, John J. Mastrototaro, Benyamin Grosman
  • Patent number: 9989490
    Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 5, 2018
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Ning Yang, Raghavendhar Gautham, Bradley C. Liang, Rajiv Shah
  • Patent number: 9949673
    Abstract: A subcutaneous sensor system includes a sensor, a plurality of reservoirs, a plurality of pumps, a mixer provided with a plurality of mixer inlets and a mixer outlet, and a controller having an input coupled to the sensor output and a plurality of control outputs coupled to the plurality of pumps and the mixer. In certain embodiments, the system further includes an enclosure for the reservoirs, the pumps, the mixer and the controller, e.g. in the form of a skin patch or in the form of an implantable enclosure. In certain embodiments, the sensor is external to the enclosure and implanted beneath the skin tissue.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: April 24, 2018
    Assignee: MAXIM lNTEGRATED PRODUCTS, INC.
    Inventor: John F. Di Cristina
  • Patent number: 9931068
    Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the analyte indicator, a membrane covering at least a portion of the analyte indicator, and/or one or more drug eluting polymer matrices, which may be external to or within the sensor housing.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: April 3, 2018
    Assignee: Senseonics, Incorporated
    Inventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
  • Patent number: 9907491
    Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: March 6, 2018
    Assignee: Medtronic Minimed, Inc.
    Inventors: Xialong Li, Brian T. Kannard, Rajiv Shah