Glucose Patents (Class 600/316)
  • Patent number: 11517267
    Abstract: An apparatus with a first photodetector and a second photodetector is provided. The apparatus is configured to receive light, and the first photodetector is configured to detect a first portion of the light. The first photodetector and the second photodetector are in a stacked arrangement and the apparatus is configured to pass a second portion of the light through the first photodetector to the second photodetector. The apparatus further includes an optical blocking filter configured to filter the second portion of the light prior to the second portion of the light arriving at the second photodetector.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: December 6, 2022
    Assignee: Nokia Technologies Oy
    Inventors: Kim Blomqvist, Leo Karkkainen, David Bitauld
  • Patent number: 11513070
    Abstract: A system for non-invasively measuring an analyte in a vehicle driver and controlling a vehicle based on a measurement of the analyte. At least one solid-state light source is configured to emit different wavelengths of light. A sample device is configured to introduce the light emitted by the at least one solid-state light source into tissue of the vehicle driver. One or more optical detectors are configured to detect a portion of the light that is not absorbed by the tissue of the vehicle driver. A controller is configured to calculate a measurement of the analyte in the tissue of the vehicle driver based on the light detected by the one or more optical detectors, determine whether the measurement of the analyte in the tissue of the vehicle driver exceeds a pre-determined value, and provide a signal to a device configured to control the vehicle.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: November 29, 2022
    Assignee: Automotive Coalition for Traffic Safety, Inc.
    Inventors: Johannes Koeth, Nicolas Koslowski
  • Patent number: 11497421
    Abstract: A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: November 15, 2022
    Inventors: Yun S Park, Sang Kon Bae, So Young Lee
  • Patent number: 11445910
    Abstract: Methods and systems for providing therapy related data management are provided. The subject systems include one or more device components, and at least one memory storage unit and at least one data storage unit associated with such one or more device components. The device components may include one or more of an analyte monitoring system, a fluid delivery device and a remote terminal. The subject methods include use of the subject systems to optimize treatment of a patient.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: September 20, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventor: R. Curtis Jennewine
  • Patent number: 11432772
    Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: September 6, 2022
    Assignee: Dexcom, Inc.
    Inventors: Apurv Ullas Kamath, Aarthi Mahalingam, Ying Li, Mohammad Ali Shariati, James H. Brauker, Mark C. Brister, Robert Boock
  • Patent number: 11432748
    Abstract: The invention comprises a method and apparatus for sampling optical pathways having a common tissue depth, such as a maximum mean depth of penetration in the dermis, with a common detector of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and detecting, using a common detector, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: September 6, 2022
    Inventors: Roxanne Abul-Haj, Kevin Hazen, Christopher Slawinski, Benjamin Mbouombouo, Alodeep Sanyal, Alan Abul-Haj
  • Patent number: 11435269
    Abstract: A testing system for evaluating the performance of an electrical/electronic UUT under dynamic operating conditions. The testing system includes a dynamic testing component (e.g., a centrifuge) for applying a stimulus to the UUT, and an iDAQ system configured to perform in situ data acquisition and real-time data analysis. The iDAQ system may also be subject to the stimulus. The iDAQ system includes a processor (e.g., an SoC) component, a power supply, a CR/I component, an IR component, and a single enclosure. The processor component may control the dynamic testing component, including varying in real-time the stimulus applied to the UUT. The processor component may include multiple input channels, and a high current/voltage subcomponent of the power supply may be configured to supply up to five hundred volts.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: September 6, 2022
    Inventors: Mohammad K. Benyhesan, Richard W. Spengemann, II
  • Patent number: 11406266
    Abstract: A system is provided for advanced health monitoring and diagnosis based on wearable nano-biosensing networks. Nanophotonic and wireless communication technologies are synergistically leveraged to bridge the gap between nano-biosensing technologies and commercial wearable devices. Embodiments of the presently-disclosed system may include: (1) a nanoplasmonic biochip, implanted subcutaneously and built on a flexible substrate; (2) a nanophotonic smart band or wearable device that is able to collect in-vivo signals on-demand and relay them wirelessly to the user's smartphone by means of a secure data transfer; and (3) advanced signal processing techniques implemented on a remote processor to extract relevant data from the received signals and provide a diagnosis in real-time.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 9, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Josep Jornet, Liang Feng, Edward P. Furlani, Qiaoqiang Gan, Zhi Sun, Yun Wu
  • Patent number: 11406331
    Abstract: Methods of determining when to activate an analyte, e.g. glucose, related alarm, such as a hypoglycemia alarm, of a continuous analyte monitor is provided. Also provided are systems, devices and kits.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: August 9, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Erwin Satrya Budiman
  • Patent number: 11373748
    Abstract: An integrated circuit includes circuitry to control a process. The process includes adjusting fuzzy-logic control parameters based on received and retrieved blood glucose-related data, predicting blood glucose levels based on the received blood-glucose-related data, and generating control signals to control dispensing of insulin based on the received blood glucose-related data and the fuzzy-logic control parameters. The process may include predicting blood glucose levels based on the retrieved blood glucose-related data. The process may include transitioning between a post-meal correction protocol and a fasting protocol. The process may include transitioning from a post-meal correction protocol to a fasting protocol when a fasting criteria is satisfied.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: June 28, 2022
    Assignee: DEXCOM, INC.
    Inventors: Robert C. Kircher, Jr., Richard S. Mauseth, Jason N. Bishop, Donald P. Matheson, Suray Bhatia, Jeff A. Bilmes
  • Patent number: 11350856
    Abstract: This electronic device includes a sensor that acquires a pulse wave of a subject, and a controller that estimates the blood glucose level of the subject on the basis of an estimation expression that is created on the basis of a blood glucose level and a pulse wave corresponding to the blood glucose level, and the pulse wave of the subject acquired by the sensor.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: June 7, 2022
    Assignee: KYOCERA Corporation
    Inventor: Hiromi Ajima
  • Patent number: 11355238
    Abstract: A system, computer program product, method and algorithm for evaluation of blood glucose variability—one of the most important parameters of diabetes management. An embodiment of the method may use routine self-monitoring blood glucose (SMBG) data collected over a period of 2-6 weeks, for example, based on a theory of risk analysis of blood glucose data. One aspect may include a method, system and computer program product for computing the Average Daily Risk Range (ADRR)—a measure of overall glucose variability. Another aspect may include a method, system, and computer program product for estimating separately the glucose variability in the hypoglycemic range via a Low BG Index (LBGI) and the glucose variability in the high BG range via High BG Index (HBGI) followed by a combination of the two indices into a single variability display.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: June 7, 2022
    Assignee: University of Virginia Patent Foundation
    Inventor: Boris P. Kovatchev
  • Patent number: 11344234
    Abstract: A circuit arrangement for an optical monitoring system comprises a driver circuit which is configured to generate at least one driving signal for driving the light source. A detector terminal is arranged for receiving a detector current from an optical detector. A gain stage is connected at its input side to the driver circuit for receiving the driving signal and generates a noise signal depending on the driving signal. A processing unit is configured to generate an output signal depending on the detector current and the noise signal.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: May 31, 2022
    Assignee: AMS AG
    Inventors: Peter Trattler, Karl Georg Waser, Herbert Lenhard
  • Patent number: 11337625
    Abstract: Various embodiments of a sealed package and a method of forming such package are disclosed. The package includes a housing, a substrate hermetically sealed to the housing, and a light source disposed on a first major surface of the substrate. The package further includes a detector disposed on the first major surface of the substrate and having a detecting surface. The package also includes a masking layer disposed on at least one of the first major surface and a second major surface of the substrate, where the masking layer includes a first aperture aligned with an emission axis of the light source in a direction orthogonal to the first major surface of the substrate. The masking layer further includes a second aperture aligned with a detection axis of the detector in a direction orthogonal to the first major surface of the substrate.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: May 24, 2022
    Assignee: Medtronic, Inc.
    Inventors: Mark R. Boone, Jonathan L. Kuhn
  • Patent number: 11313788
    Abstract: A body fluid analysis device includes a light source, a detector, a normalization part, and a calculation part. The light source is configured to emit light at a first wavelength and light at a second wavelength different from each other to a body fluid. The detector is configured to receive light emitted from the light source and transmitted through the body fluid or light reflected by the body fluid, and is configured to detect intensity of the light. The normalization part is configured to calculate a ratio of an intensity of light emitted at the second wavelength to an intensity of light emitted at the first wavelength, both of which are detected by the detector. The calculation part is configured to calculate a concentration of a predetermined component included in the body fluid on the basis of the ratio calculated by the normalization part.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: April 26, 2022
    Assignee: GENIAL LIGHT CO., LTD.
    Inventors: Ryo Shimokita, Takashi Sawada, Tatsuyuki Fujita
  • Patent number: 11304634
    Abstract: A non-invasive blood sensor includes a body configured to mate with a tissue surface; a blue light source disposed on the sensor body; and a photodetector disposed on the sensor body at a suitable position for capturing light emanating from the tissue surface after emission from the blue light source, e.g., by one of: transmission, reflection, and transflection. The sensor bodies may further include a green, a red and/or an infrared light source. The light source(s) and photodetector(s) may be supported on a support structure configured to register with a corresponding portion of human anatomy in a predetermined fashion, and support the light sources and photodetectors in a defined spatial relationship. The sensor or an integrated meter may include a controller programmed to receive signals from the photodetector and calculate blood glucose value as function of the signals received from the photodetector after emission by the light source(s).
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: April 19, 2022
    Assignee: Basil Leaf Technologies, LLC
    Inventors: Basil M. Harris, George C. Harris, Edward L. Hepler
  • Patent number: 11307064
    Abstract: An apparatus for processing multi-type sensor signals on the basis of multi-modal deep learning, the apparatus including: an individual sensor failure diagnosis unit configured to measure a normality of a sensor output of a single modal sensor at each sampling period, and sense an abnormal operation of the sensor on the basis of the measured normality; an inter-sensor mutual failure diagnosis unit including a multi-modal deep auto encoder, and configured to learn a correlation existing between multi-modalities, extract shared representation between modalities from multi-modal inputs on the basis of the learned correlation, and perform an inter-sensor mutual failure diagnosis; and a reconstruction target sensor output value reconstructing unit configured to, when an output value of a specific sensor is missing, predict and reconstruct the output value of the sensor using other sensor information using the shared representation extracted from other modal sensors.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: April 19, 2022
    Assignee: Industry-Academic Cooperation Foundation, Dankook University
    Inventors: Sang-Il Choi, Haanju Yoo
  • Patent number: 11298058
    Abstract: Devices and methods for positioning a portion of a sensor at a first predetermined location, displacing the portion of the sensor from the first predetermined location to a second predetermined location, and detecting one or signals associated with an analyte level of a patient at the second predetermined location are disclosed. Also provided are systems and kits for use in analyte monitoring.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: April 12, 2022
    Inventor: Gary Ashley Stafford
  • Patent number: 11275154
    Abstract: A method of correcting a measurement value of a laser scanner includes: in a laser scanner including a light emitting unit, a light receiving unit, a distance measuring unit, an optical axis deflecting unit having at least a pair of prisms deflecting a distance measuring light and a reflected distance measuring light, and an emitting direction detecting unit detecting a deflection angle and an emitting direction of the distance measuring light from the optical axis deflecting unit, (a) measuring a distance to a measurement point, (b) detecting rotation angles of the prisms, and (c) obtaining, based on rotation angles of the prisms, a true distance measurement value corrected for a length of an optical path length difference in light emission and/or light reception caused according to the rotation angles of the prisms by subtracting the optical path length difference from a distance measurement value of the distance measuring unit.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: March 15, 2022
    Inventors: Ikuo Ishinabe, Taichi Yuasa
  • Patent number: 11229363
    Abstract: Provided are apparatuses and methods for detecting biological information. An apparatus for detecting biological information may include a biological signal measurement unit having at least two light emission elements having different light emission angles. The at least two light emission elements may include different types of light sources. The at least two light emission elements may include multiple light sources of the same type, and in this case, an optical element configured to adjust a light emission angle of one of the light sources may be provided. The apparatus for detecting biological information may include a biological signal measurement unit including a light emitting unit having variable light emission angle. The apparatus for detecting biological information may further include a data processor configured to extract and analyze biological information of a subject from data measured by the biological signal measurement unit.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: January 25, 2022
    Inventors: Yongjoo Kwon, Jaemin Kang, Sunkwon Kim
  • Patent number: 11229383
    Abstract: A device is described for interrogating human skin using tight coupling between the transmitter and receiver of the millimeter waves (MMWs). Methods are provided to evaluate changes in the amplitude and/or phase of the transmitted MMWs in order to estimate the blood concentration of glucose. Using this device and the related methods, the blood glucose concentration or a change in the blood glucose concentration can be monitored for diagnosing diabetes mellitus and other metabolic disorders of carbohydrate metabolism characterized by either high blood glucose level (hyperglycemia) or low blood glucose level (hypoglycemia), as well as for monitoring (including self-monitoring) a metabolic disorder progression or an efficacy of treatment.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: January 25, 2022
    Inventors: Victor Pikov, Peter H. Siegel
  • Patent number: 11224365
    Abstract: Disclosed is a fully implantable sensor for detecting at least one analyte in a sample of body fluid. The sensor has a measurement chamber plate that receives the sample of bodily fluid and a quantum cascade laser illumination source that generates an illumination light beam in the spectral range and transmits it to the measurement chamber plate. The illumination light beam at least partially illuminates the measurement chamber plate and the measurement chamber plate generates a reflection light beam in response to the illumination by the illumination light beam. The reflection light beam at least partially illuminates the sample of body fluid within the measurement chamber plate. An optical detector detects at least one property of the reflection light beam and generates a sensor signal dependent on the presence of the analyte. A controlled evaluates the sensor signal. A method using an inventive fully implantable sensor is also disclosed.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: January 18, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Frank Deck, Hans List, Wolfgang Petrich, Niels Kroeger-Lui, Katharina Haase
  • Patent number: 11199451
    Abstract: A measurement apparatus includes: a light source configured to irradiate a measurement region of skin whose color is to be measured with light; a light receiving unit configured to receive reflected light from the measurement region or transmitted light that has passed through the measurement region; a calculation unit configured to repeatedly obtain determination information and color information relating to the color of the measurement region, based on a light-receiving result of the light receiving unit; and a selection unit configured to select a measurement result of a color of the skin from the repeatedly-obtained color information, based on a temporal change in the determination information.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: December 14, 2021
    Assignee: Canon Kabushiki Kaisha
    Inventor: Tomoyuki Saiki
  • Patent number: 11170199
    Abstract: Systems and methods for visualizing, and/or determining the amount of, collagen and elastin in tissue are provided. Training data can be generated using Mueller matrix polarimetry microscopy data, combined with second harmonic generation (SHG) and/or two photon excitation fluorescence (TPEF) microscopy data as ground truth. The SHG and/or TPEF data can be used to train a neural network for feature extraction, and classification can be performed. The components and decompositions of the Mueller matrix data can be arranged as individual channels of information, forming one voxel per sample.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: November 9, 2021
    Inventors: Jessica Claudia Ramella-Roman, Camilo Roa, Vinh Du Le, Ilyas Saytashev
  • Patent number: 11147508
    Abstract: Utilizing a computing device to generate a personalized maternal nutrition plan for a pregnant mother. The computing device receives real-time maternal physiological data, fetal physiological data, and real-time environmental data associated with the pregnant mother. A real-time relationship is established. The real-time relationship is compared with historically established relationships between pregnant mothers and fetuses. The maternal physiological data is compared with pre-pregnancy data of the pregnant mother. The computing device detects one or more abnormalities in the real-time established relationship between the pregnant mother and the fetus based upon the comparison of the real-time established relationship with historically established relationships and the comparison of the maternal physiological data with pre-pregnancy data of the pregnant mother. The computing device generates a maternal nutrition plan.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: October 19, 2021
    Assignee: International Business Machines Corporation
    Inventors: Elezaveta Koumpan, Vandana Pandey, Pamela A. Nesbitt
  • Patent number: 11144576
    Abstract: A method may include sensing first data samples from a first set of different subjects having a membership in a target class and sensing second data samples from a second set of different subjects not having a membership in the target class, wherein each of the first data samples and the second data samples includes a composite of individual data features. The individual data features from each composite of the first data samples and the second data samples are extracted and quantified. Sets of features and associated weightings of a target class model are identified based upon quantified values of the individual features from each composite of the first samples and the second samples to create a model representing a fingerprint of the target class to determine membership status of a sample having an unknown membership status with respect to the target class.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: October 12, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Lei Liu, Anita Rogacs
  • Patent number: 11122996
    Abstract: A blood glucose measurement device, a blood glucose calculation method, and a blood glucose calculation program capable of accurately measuring a blood glucose level by using light are provided. The blood glucose measurement device includes a light source 11 that outputs measurement light L1 to be input to a living body 50; a light detector 12 that detects the measurement light L1 propagated inside the living body 50 and generates a detection signal in accordance with an intensity of the measurement light L1; and a computation unit that obtains a time lag between a temporal change in a first parameter related to an oxygenated hemoglobin concentration and a temporal change in a second parameter related to a deoxygenated hemoglobin concentration based on the detection signal, and obtains the data related to the blood glucose level based on the time lag.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: September 21, 2021
    Inventors: Tomoya Nakazawa, Rui Sekine, Masato Kitabayashi, Anna Ienaka, Yu Hashimoto
  • Patent number: 11103181
    Abstract: A bio-information processing apparatus includes: an in vivo material measurer which measures an in vivo material of a user; and a processor which extracts a pattern of change of the in vivo material of the user based on a measurement result of the in vivo material, compares the extracted pattern of change of the in vivo material with a biological rhythm reference model, and determines whether biological rhythms of the user are disrupted based on a result of the comparison.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: August 31, 2021
    Inventors: Ki Young Chang, Jung Yong Nam, Kun Sun Eom, Joon Hyung Lee
  • Patent number: 11089981
    Abstract: A method includes processing near infrared spectroscopy (NIR) spectra and pure spectra, to obtain a preprocessed NIR spectra, wherein the preprocessed NIR spectra includes any one or any combination of a training data of a plurality of subjects, a calibration data of a test subject and a validation data of the test subject, extracting a dominant feature set from the preprocessed NIR spectra, wherein the dominant feature set includes at least one preprocessed NIR spectrum corresponding to each of the training data, the calibration data and the validation data, and determining a blood glucose concentration of the test subject, using the training data of the plurality of subjects and based on the extracted dominant feature set.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: August 17, 2021
    Inventors: Gorish Aggarwal, Kiran Bynam, So Young Lee, Ibrahim A, Sujit Jos, Rahul Arora
  • Patent number: 11083374
    Abstract: A spectrometer includes a chamber, a vacuum generator configured to suck in internal air of the chamber to pull skin of a subject into the chamber, a light source configured to emit light to the skin of the subject pulled into the chamber, a photodetector configured to receive light passing through the skin of the subject and acquire a spectrum of the light; and a skin contact adjuster configured to determine a contact state between the chamber and the skin by analyzing the spectrum of the light and thereby generate a determination result, and adjust the contact state between the chamber and the skin by applying a physical force to a periphery of the skin pulled into the chamber according to the determination result.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: August 10, 2021
    Inventors: Seung Jun Lee, June Young Lee, Jung Mok Bae, Eui Seok Shin
  • Patent number: 11076785
    Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.
    Type: Grant
    Filed: August 19, 2017
    Date of Patent: August 3, 2021
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Gary Alan Hayter, Geoffrey V. McGarraugh, Kenneth J. Doniger
  • Patent number: 11058331
    Abstract: An analyte sensor includes a detector array having at least two detector elements, for example antennas or light emitting diodes, that transmit electromagnetic energy. Any one or more of the detector elements in the detector array can be selectively controlled to function as a transmit detector element that functions to transmit a generated transmit signal in a radio or microwave or visible light frequency range of the electromagnetic spectrum into a target containing an analyte of interest. In addition, any one or more of the detector elements in the detector array can be selectively controlled to function as a receive detector element that functions to detect a response resulting from transmission of the transmit signal by the transmit detector element into the target. A scan routine can be implemented that includes a plurality of scans, where each scan uses a different combination of the detector elements to transmit a signal and detect a response.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: July 13, 2021
    Assignee: KNOW LABS, INC.
    Inventor: Phillip Bosua
  • Patent number: 11051727
    Abstract: A method of non-invasively monitoring advanced glycation end-product (AGE) concentrations includes providing incident light to patient tissue at one or more excitation wavelengths and monitoring the one or more emission responses at one or more emission wavelengths. Based on the emission responses monitored, a ratio is calculated based on a ratio of the first emission response to the second emission response.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: July 6, 2021
    Assignee: Medtronic Monitoring, Inc.
    Inventor: Rodolphe Katra
  • Patent number: 11051706
    Abstract: Systems, devices, and methods for tracking one or more physiological metrics (e.g., heart rate, blood oxygen saturation, and the like) of a user are described. For example, one or more light sources and one or more light detectors may be positioned on a wearable device such that light can be emitted towards the user's skin and further such that light reflected back to the wearable device can be measured and used to generate values for the one or more physiological metrics.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: July 6, 2021
    Assignee: Fitbit, Inc.
    Inventors: Kyle P. Nadeau, Chris H. Sarantos, Kevin Pu Weekly, Javier L. Prieto, Peter W. Richards, Paul Francis Stetson, Aniket Sanjay Deshpande
  • Patent number: 11020027
    Abstract: An apparatus for estimating a glucose exposure may include: a spectrometer configured to measure a plurality of Raman spectra from an object; and a processor configured to extract depth-specific protein information from the plurality of Raman spectra and estimate the glucose exposure of the object based on the depth-specific protein information.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: June 1, 2021
    Inventors: Jin Young Park, Un Jeong Kim, Yun S Park, Sung Mo Ahn
  • Patent number: 11013410
    Abstract: Implantable sensors are described that can be utilized in conjunction with orthopedic implants for monitoring fracture healing and detecting local chemical concentrations to detect and monitor implant associated infection. The sensors can include strain gauges, electrochemical, or spectrochemical sensors that can be read transdermally using a single photodetector. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the local concentration of infection biomarkers, for instance to monitor the implant area for early stage infection.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: May 25, 2021
    Assignee: Aravis BioTech, LLC
    Inventors: Jeffrey N. Anker, Donald W. Benza
  • Patent number: 10987468
    Abstract: A multi-modal medicine delivery system in which some embodiments can be configured to control dispensation of medicine according to any of a plurality of delivery modes, such as by closed-loop delivery modes and open-loop delivery modes, and according to a secondary feedback loop to determine user-specific settings related to dosage delivery.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: April 27, 2021
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Bryan Mazlish, Lane Desborough
  • Patent number: 10984912
    Abstract: A method and apparatus that for monitoring the physiological state of nutrition of an individual and adaptively analyze that data input to anticipate the individual's nutritional needs. A satiety meter may be employed to analyze a user's profile including nutritional state and determine when and how much a user should consume to prevent the onset of hunger and communicate is to a decision engine. The decision engine may generate and communicate a message to the user via the client device to prescribe prophylactic intake of nutrition to the individual prior to the onset of hunger based on the user's nutrition plan and/or regimen.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: April 20, 2021
    Inventors: Seth Haberman, Joseph Bernstein
  • Patent number: 10973442
    Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: April 13, 2021
    Assignee: St. Louis Medical Devices, Inc.
    Inventor: Zhi Xu
  • Patent number: 10968035
    Abstract: In certain embodiments, the invention relates to an article having a liquid-impregnated surface. The surface includes a matrix of solid features (e.g., non-toxic and/or edible features) spaced sufficiently close to stably contain a liquid therebetween or therewithin, wherein the liquid is non-toxic and/or edible. The article may contain, for example, a food or other consumer product, such as ketchup, mustard, or mayonnaise.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: April 6, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Jonathan David Smith, Rajeev Dhiman, Adam T. Paxson, Christopher J. Love, Brian R. Solomon, Kripa K. Varanasi
  • Patent number: 10955270
    Abstract: A physiological monitor gauge panel defines parameters to display on a physiological monitor via corresponding gauges. Gauge faces depict a range of parameter values for each of the parameters. An indicator designates a position on each gauge face corresponding to the current parameter value within the range of parameter values. The indicated position on each of the gauges is at the mid-point of each of the gauge faces when each of the parameters is at a nominal value.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 23, 2021
    Assignee: Masimo Corporation
    Inventors: Ammar Al-Ali, Bilal Muhsin, Keith Indorf, Massi Joe E. Kiani
  • Patent number: 10932702
    Abstract: A method for noninvasive determination of glucose content in blood. The method includes optically irradiating a biomaterial alternately in any sequence with optical radiation of a first wavelength band of 950-970 nm, optical radiation of a second wavelength band of 1020-1060 nm, optical radiation of a third wavelength band of 930-950 nm, optical radiation of a fourth wavelength band of 740-760 nm and optical radiation of a fifth wavelength band of 830-850 nm, receiving Ron with a receiver the optical radiation diffusely reflected by the biomaterial, converting the received optical radiation into an electric signal and determining the glucose concentration in blood on the basis of the sum of the electric signals received at radiation treatment of the biomaterial with the optical radiation of the second, third and fourth bands which is reduced by values determined by the electric signal received at radiation treatment of the biomaterial with optical radiation of the first and fourth bands.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: March 2, 2021
    Inventors: Edvard Vladimirovich Kryzhanovskii, Artem Sergeevich Adzhemov, Armen Gareginovich Grigoryan
  • Patent number: 10918319
    Abstract: An apparatus for estimating a biological substance in a user using a unit spectrum for the biological substance acquired using a biological tissue simulation solution is provided. The apparatus may include a spectrometer configured to emit a light to a skin of a user, detect the light returned from the skin, and measure a skin spectrum of the user from the detected light and a processor configured to estimate a biological substance in the user based on the measured skin spectrum and a unit spectrum acquired using a biological tissue simulation solution.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: February 16, 2021
    Inventors: So Young Lee, Jin Young Park
  • Patent number: 10912499
    Abstract: The present invention provides a detecting apparatus based on image for detecting blood glucose concentration and method thereof. The detecting apparatus comprising a lighting device, an image capture device, a thermal imager and an operating device. The lighting device including a first wavelength of light source and a second wavelength of light source, configured to illuminate skin. The image capture device disposed above the lighting device, configured to capture a first image and a second image corresponding to the first wavelength of light source and the second wavelength of light source illuminated on the skin respectively. The thermal imager is configured to detect temperature of the skin. The operating device is connected to the lighting device, the image capture device and the thermal imager, configured to calculate blood glucose concentration according to the first image, the second image and the temperature.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: February 9, 2021
    Inventors: Hsin-Yi Tsai, Kuo-Cheng Huang, Ching-Ching Yang, Tzu-Ting Wei
  • Patent number: 10888272
    Abstract: Systems, devices, and methods for detecting, measuring and classifying meals for an individual based on analyte measurements. These results and related information can be presented to the individual to show the individual which meals are causing the most severe analyte response. These results can be organized and categorized based on preselected criteria or previous meals and results so as to organize and present the results in a format with reference to glucose as the monitored analyte. Various embodiments disclosed herein relate to methods, systems, and software applications intended to engage an individual by providing direct and timely feedback regarding the individual's meal-related glycemic response.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: January 12, 2021
    Inventors: Gary A. Hayter, Timothy C. Dunn, Nathan Crouther
  • Patent number: 10856786
    Abstract: A system and method for controlling and monitoring a diabetes-management system through the use of a model that predicts or estimates future dynamic states of glucose and insulin from variables such as insulin delivery or exogenous glucose appearance as well as inherent physiological parameters. The model predictive estimator can be used as an insulin bolus advisor to give an apriori estimate of postprandial glucose for a given insulin delivery profile administered with a known meal to optimize insulin delivery; as a supervisor to monitor the operation of the diabetes-management system; and as a model predictive controller to optimize the automated delivery of insulin into a user's body to achieve a desired blood glucose profile or concentration. Open loop, closed-loop, and semi-closed loop embodiments of the invention utilize a mathematical metabolic model that includes a Minimal Model, a Pump Delivery to Plasma Insulin Model, and a Meal Appearance Rate Model.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: December 8, 2020
    Inventors: Garry M. Steil, Sami S. Kanderian, Jr., Martin T. Cantwell, Udo Hoss
  • Patent number: 10835718
    Abstract: A catheter device to visually identify a blood vessel may include a cannula. The cannula may include a distal tip, an elongated tubular shaft, and an inner lumen formed by the elongated tubular shaft. The cannula may also include an optical fiber, which may be disposed within the inner lumen of the cannula. The optical fiber may include a distal end and a proximal end. The optical fiber may be configured to emit light from the distal end.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: November 17, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: S. Ray Isaacson, Ralph L. Sonderegger, Jonathan Karl Burkholz
  • Patent number: 10827956
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: November 10, 2020
    Assignee: DexCom, Inc.
    Inventors: Mark C. Brister, Peter C. Simpson, Matthew D. Wightlin, Steve Masterson, James R. Petisce, John Nolting, Jack Pryor, Sean Saint, Vance Swanson, James H. Brauker, Apurv Ullas Kamath, Paul V. Goode, Jr., Aarthi Mahalingam
  • Patent number: 10828138
    Abstract: Embodiments of the present invention are directed to a system for automated intra-oral delivery of therapeutic agents. A non-limiting example of the system includes a delivery vessel including a control unit and a reservoir. The system can also include a connector tube including a channel coupled to the delivery vessel. The system can also include a sensor coupled to connector tube.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: November 10, 2020
    Inventors: Amos Cahan, Sufi Zafar
  • Patent number: 10804562
    Abstract: A computer-implemented method for determining a concentration of a component of an electrolyte in a lithium-ion or for a lithium-ion cell is provided. The method includes providing, to a spectrometer, instructions to capture a spectrum of a sample solution of the electrolyte and generate a signal. The method includes analyzing the signal to determine one or more spectral features of the spectrum. The method includes preparing a database of spectra corresponding to solutions having predetermined concentrations of the component of the electrolyte wherein the database includes a plurality for spectral features for each solution. The method further includes determining a machine learning (ML) model using the database of spectra. The method includes determining the concentration of the component of the electrolyte in the sample solution using the machine learning model.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: October 13, 2020
    Assignee: Tesla Motors Canada ULC
    Inventors: Leah Devorah Ellis, Samuel Buteau, Samuel Gerard Carson Hames, Jeffery R. Dahn, David Scott Hall