Abstract: An apparatus for estimating biological information may include a sensor configured to detect a first light signal and a second light signal from an object of a user and a processor configured to determine whether a condition for estimating biological information is satisfied based on the detected first light signal and estimate biological information based on the second light signal, wherein the sensor includes a force sensor configured to measure a force applied to the object when the object is in contact with a cover surface of the sensor.

Abstract: The present invention is to provide an apparatus and a method for obesity prevention and weight regulation, which can efficiently regulate and manage gaining and losing weight by maintaining a blood sugar level suitable for a personal situation through regulation of eating food and activity regulation by using a blood sugar value measured using noninvasively measuring blood sugar.

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

Abstract: The present disclosure relates to systems, devices and methods for receiving biosensor data acquired by a medical device, e.g., relating to glucose concentration values, and controlling the access and distribution of that data. In some embodiments, systems and methods are disclosed for monitoring glucose levels, displaying data relating to glucose values and metabolic health information, and controlling distribution of glucose data between applications executing on a computer, such as a smart phone. In some embodiments, systems and methods are disclosed for controlling access to medical data such as continuously monitored glucose levels, synchronizing health data relating to glucose levels between multiple applications executing on a computer, and/or encrypting data.

Abstract: A blood glucose sensing system includes a plurality of physiological sensors. The system can estimate blood glucose based on discrete invasive blood glucose estimates from a blood sample, discrete noninvasive blood glucose estimates derived from optical sensors, and continuously-calculated blood glucose estimates derived from a nonlinear state-space model of glucose and insulin reactions within a human body. The state-space model has user-entered values corresponding to their insulin and meal intake. The user's blood glucose is estimated from a combination of the discrete invasive blood glucose estimates, the discrete noninvasive blood glucose estimates and the continuously-calculated blood glucose estimate.

Abstract: Systems and methods are provided to determine a time to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a model or pattern. The time to deliver guidance may be calculated to be useful to a user in the management of a glucose concentration level.

Abstract: A system which includes an apparatus for generating radio frequency scanning data which includes a transmitter for transmitting radio waves below the skin surface of a person and a two-dimensional array of receive antennas for receiving the radio waves, including a reflected portion of the transmitted radio waves that is reflected from a blood vessel of the person. The wave signal is compared to known standard waveforms, and similar waveforms are input into a machine learning algorithm to determine one or more health parameters of the person. The system then notifies the person and/or health professionals of the person's health status. The health parameters can be used to trigger other software and hardware modules such as another measurement device, a medication scheduler or alert, medical recommendations, guidance software, a virtual assistant, or any other hardware and/or software which may help the patient or health professionals.

Abstract: A blood measurement device (10) includes a light emitting part (11) that emits a light beam that is to transmit through a measurement site (18), a light receiving part (19) that receives the light beam that has transmitted through the measurement site (18), an integrating sphere part (14) interposed in an optical path along which the light beam emitted from the light emitting part (11) reaches the light receiving part (19), the integrating sphere part (14) having formed inside a reflection surface (26) that reflects the light beam, a light entry part (23) which is an opening provided at the integrating sphere part (14) and through which the light beam applied from the light emitting part (11) enters an inside of the integrating sphere part (14), and a light exit part (16) which is an opening provided at the integrating sphere part (14) and through which the light beam reflected by the reflection surface (26) of the integrating sphere part (14) is emitted from the integrating sphere part (14) toward the measur

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

Abstract: The present disclosure relates to systems, devices and methods for receiving biosensor data acquired by a medical device, e.g., relating to glucose concentration values, and controlling the access and distribution of that data. In some embodiments, systems and methods are disclosed for monitoring glucose levels, displaying data relating to glucose values and metabolic health information, and controlling distribution of glucose data between applications executing on a computer, such as a smart phone. In some embodiments, systems and methods are disclosed for controlling access to medical data such as continuously monitored glucose levels, synchronizing health data relating to glucose levels between multiple applications executing on a computer, and/or encrypting data.

Abstract: A method of non-invasively monitoring advanced glycation end-product (AGE) concentrations includes providing incident light to patient tissue at one or more excitation wavelengths and monitoring the one or more emission responses at one or more emission wavelengths. Based on the emission responses monitored, a ratio is calculated based on a ratio of the first emission response to the second emission response.

Abstract: A non-invasive monitoring device for monitoring physiological condition of a subject may include at least one light source for emitting light at at least one predetermined narrow spectral wavelength band onto a living tissue of the subject and two or more light sensors. Each of the two or more light sensors may correspond to a specific substance in a living tissue of the subject and may be configured to measure a change in a concentration of the specific substances to which the sensor corresponds. The distance of each of the two or more sensors from the light source, may be determined so that intensity of light scattered by each specific substance, may have a maximal signal to noise ratio at the determined distance of the corresponding sensor.

Abstract: The present disclosure is directed to machine learning of electrical power system behavior, and related systems, apparatuses, and methods. A controller of an electrical power system includes a data storage device configured to store model data indicating a model load power consumed by loads of the electrical power system. The controller also includes a processor configured to determine current data including current load power consumed by the loads, modify the model data by aggregating the model data with the current data, and determine a set of control values for a set of control variables to effectuate a change to operation of the electrical power system based, at least in part, on the model data.

Abstract: An eye accommodation distance determining device is provided. The eye accommodation distance determining device includes an interferometer configured to generate a plurality of frequency modulated laser beams in different directions and to generate a plurality of interferometric signals using laser beams reflected from eye reflecting surfaces, a signal processer configured to generate a signal spectrum using each of said plurality of interferometric signals, a distance determiner configured to determine distances to the eye reflecting surfaces for each of said plurality of frequency modulated laser beams, a point coordinates determiner configured to determine coordinates of points on each of the eye reflecting surfaces for each of the laser beams, a reconstructor configured to generate an eye inner structure model based on the determined coordinates of points, and an eye accommodation distance determiner configured to determine, based on said eye inner structure model, an eye accommodation distance.

Abstract: An objective of the present invention is to provide an optical measurement device capable of performing remote optical measurement. An optical measurement device may include a light source that generates irradiation light with a beam shape, a beam control unit configured to control an irradiation direction of the irradiation light L1, a condensing unit configured to condense returned light generated by irradiating a part of a measurement target with the irradiation light, and a detection unit configured to detect information regarding the measurement target included in the returned light condensed by the condensing unit. The beam control unit can control the irradiation direction of the irradiation light for measurement to any direction, and thus the condensing unit can efficiently receive the faint returned light from the measurement target.

Abstract: The present disclosure relates to a connector for an infusion set. The connector comprises a body and at least one arm connected to the body which is configured to couple with a base of an infusion set; wherein the body has a first portion and a second portion which are configured to be removably and replaceably coupled together; and wherein each portion has a fluid delivery conduit, the conduits being configured to allow fluidic communication of the connector with at least two independent fluid sources. Also disclosed is an infusion set.

Abstract: The invention relates to a device and a method for optoacoustic sensing, wherein an irradiation unit is configured to generate at least one train of periodic pulses of electromagnetic energy, the pulses of the at least one train of periodic pulses exhibiting a pulse duration and repetition rate, and to irradiate a target with the generated train of periodic pulses. A detection unit is configured to detect acoustic waves generated in the target and to generate an according detection signal, the detection signal comprising, for each train of the at least one train of periodic pulses, detection signal components at a plurality of discrete frequencies in the frequency domain, the discrete frequencies being spaced from each other by a frequency spacing corresponding to the repetition rate of the pulses of the at least one train of periodic pulses.

Abstract: An analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include one or more sensors and a transceiver interface. The one or more sensors may be configured to generate sensor measurements indicative of an analyte level in a first medium. The sensors may include a temperature transducer configured to generate a sensor temperature measurement, and the sensor measurements may include the sensor temperature measurement. The transceiver interface may be configured to convey the sensor measurements. The transceiver may include a sensor interface and a processor. The sensor interface may be configured to receive the sensor measurements conveyed by the analyte sensor. The processor may be configured to adjust the sensor temperature measurement and calculate an analyte level in a second medium using at least the adjusted sensor temperature measurement and one or more of the sensor measurements.

Abstract: Methods, apparatuses and systems are described that are capable of simultaneously determining the presence, identities or levels of multiple analytes present in a single sample, by carrying out steps including denaturation, normalization, extraction, mixed-mode liquid chromatography and mass spectrometry, whereby the presence, identities or levels of analytes in the single sample are determined.

Abstract: An optically stimulating module to be integrated into a probe is implantable into a living being with a view to locally illuminating a region of said living being. The module includes a casing that is at least partially transparent, and a hermetic electronic unit placed in the casing. The hermetic electronic unit includes an internal volume housing two light sources, a control and processing unit, and a first photodetector. The module also includes a connecting device for connecting the module to a central control and power unit.

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from the same tissue site. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus. The multi-sensor apparatus can orient the plurality of non-invasive, physiological sensors such that each of the plurality of non-invasive, physiological sensors obtains physiological data from the same or a similar location.

Abstract: A system for non-invasively measuring an analyte in a vehicle driver and controlling a vehicle based on a measurement of the analyte. At least one solid-state light source is configured to emit different wavelengths of light. A sample device is configured to introduce the light emitted by the at least one solid-state light source into tissue of the vehicle driver. One or more optical detectors are configured to detect a portion of the light that is not absorbed by the tissue of the vehicle driver. A controller is configured to calculate a measurement of the analyte in the tissue of the vehicle driver based on the light detected by the one or more optical detectors, determine whether the measurement of the analyte in the tissue of the vehicle driver exceeds a pre-determined value, and provide a signal to a device configured to control the vehicle.

Abstract: In one aspect, a method of estimating an HbA1c level is provided. The method may include obtaining a first and second glucose measurement, adding the first and the second glucose measurements to a glucose measurement data set, and calculating an estimated HbA1c level using at least the glucose measurement data set. In another aspect, a method of calculating a range of an estimated HbA1c level is provided. The method may comprise at least calculating an estimated HbA1c level and a standard deviation of the estimated HbA1c level using a glucose measurement data set, and combining the estimated HbA1c level with the standard deviation of the estimated HbA1c level to acquire the range of the estimated HbA1c level. In another aspect, a glucose monitoring device may display glycemic variability of an individual.

Abstract: A non-invasive method to determine a current functional blood oxygen saturation level: acquiring, at a sampling frequency, a photoplethysmography light response for each wavelength of a plurality of at least three wavelengths, resulting respectively in a first, second and third raw data series, applying a low -pass filter to each of the first, second and third raw data series, resulting respectively in a first, second and third DC data series representing an unmodulated amplitude response determining respectively in a first, second and third AC data series representing an unmodulated amplitude response, applying a. computation engine to the first, second and third AC and DC data series, and determining therefrom a user current blood oxygen saturation level.

Abstract: Disclosed herein are techniques related to model predictive control. The techniques may involve generating a desired glucose trajectory that approaches a desired steady state setpoint from a current glucose value over a prediction horizon. The techniques may involve generating a plurality of insulin delivery patterns. Each insulin delivery pattern may correspond to an amount of insulin to be delivered over a control horizon. The techniques may involve generating a plurality of predicted glucose trajectories over the control horizon. Each predicted glucose may be generated based on the current glucose value and a respective insulin delivery pattern. The techniques may involve comparing the desired glucose trajectory against each predicted glucose trajectory and selecting a predicted glucose trajectory that is more similar to the desired glucose trajectory than any other predicted glucose trajectory.

Abstract: A sensor system includes an array of optical sensors on an integrated circuit and a plurality of sets of optical filters atop at least a portion of the array. Each set of optical filters is associated with a set of optical sensors of the array, with a set of optical filters including a plurality of optical filters, with each optical filter being configured to pass light in a different wavelength range. A first interface is configured to interface with the optical sensors and first processing circuitry that is configured to execute operational instructions for receiving an output signal representative of received light from the optical sensors and determining a spectral response for each set of optical sensors.

Abstract: An optical physiological finger sensor system including an ergonomic interface shaped into a natural curve of a user's hand and finger.

Abstract: An implantable apparatus for physiological measurement in a host organism has an implantable sample chamber having a measurement port and live cells that are treated to fluoresce in response to light having an excitation wavelength. An optical sensor housing implanted within the host organism has a window to convey excitation light output and receive fluorescent light; a coupling that couples the measurement port of the sample chamber to the window; an optical chamber partitioned into an excitation sub-chamber and a detection sub-chamber, wherein both sub-chambers are in optical communication with the window; an excitation source energizable to direct excitation light through the excitation sub-chamber and to the window; and a detector in the path of fluorescent light received from the live cells. A signal processing apparatus is energizable to acquire and process a detector signal and to transmit a processed signal that is indicative of fluorescent light energy.

Abstract: A component concentration measuring apparatus includes: a dielectric spectroscopy portion that irradiates a measurement subject with electromagnetic waves and measures a complex permittivity, thereby acquiring a dielectric spectroscopy spectrum; a temperature measurement portion that measures a temperature of the measurement subject; a signal processing portion that corrects the dielectric spectroscopy spectrum according to the temperature measured by the temperature measurement portion; and a calculating portion that applies a calibration model generated in advance from a dielectric spectroscopy spectrum of a sample whose component concentration is known, to the dielectric spectroscopy spectrum corrected by the signal processing portion, thereby calculating a component concentration of the measurement subject.

Abstract: An apparatus for estimating a biological substance in a user using a unit spectrum for the biological substance acquired using a biological tissue simulation solution is provided. The apparatus may include a spectrometer configured to emit a light to a skin of a user, detect the light returned from the skin, and measure a skin spectrum of the user from the detected light and a processor configured to estimate a biological substance in the user based on the measured skin spectrum and a unit spectrum acquired using a biological tissue simulation solution.

Abstract: Systems and embodiments for a multi-pixel waveguide optical receiver are described herein. In certain embodiments, a system includes an emitter that emits laser light towards a surface. The system also includes a receiver that passively receives reflected laser light that is a portion of the laser light reflected from the surface, wherein the receiver has multiple pixels having a size that is smaller than an expected optical speckle size, wherein the expected optical speckle size corresponds to a region on the receiver where the reflected laser light has a substantially uniform spatial phase. Additionally, the system includes a combiner configured to combine optical fields from each pixel in the multiple pixels into an output that supports a number of modes that is equal to a number of pixels in the multiple pixels. Moreover, the system includes a photodetector configured to receive light from the output.

Abstract: Systems, devices, and methods for tracking one or more physiological metrics (e.g., heart rate, blood oxygen saturation, and the like) of a user are described. For example, one or more light sources and one or more light detectors may be positioned on a wearable device such that light can be emitted towards the user's skin and further such that light reflected back to the wearable device can be measured and used to generate values for the one or more physiological metrics.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more compounds that reduce degradation of the analyte indicator.

Abstract: A glucose biosensor includes a plurality of optical fibers configured for placement within the ear canal. A first optical fiber emits light into the ear canal. A plurality of other optical fibers capture and transmit the reflected light back to the glucose biosensor. A plurality of photodetectors are configured in the glucose biosensor to detect the reflected light from the plurality of optical fibers. The glucose biosensor processes the detected light from each photodetector to determine a glucose level measurement. In an embodiment, the glucose biosensor also obtains a second glucose level measurement using another method and determines a calibration for the first glucose level measurement using the second glucose level measurement.

Abstract: The present disclosure generally relates to the field of blood glucose monitoring. A device for determining a blood glucose level includes a first light emitting unit configured to emit a first light; a second light emitting unit configured to emit a second light, wherein one of the first light and the second light is configured to be insensitive to glucose content in blood; a first light receiving unit configured to generate a first signal based on the first light; and a second light receiving unit configured to generate a second signal based on the second light.

Abstract: A sensor that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing and an analyte indicator covering at least a portion of the sensor housing. The sensor may include a drug-eluting matrix that covers at least a portion of the analyte indicator. The drug-eluting matrix may include one or more openings configured to allow the medium to pass through the drug-eluting matrix and come into contact with the analyte indicator. The sensor may include one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the drug-eluting matrix.

Abstract: A system and method for monitoring the health of dialysis patients with Raman spectroscopy measurements of one or more target analytes is described. The methods include irradiating one or more fluids of interest with light to produce one or more spectrum and detecting the spectrum with a detector. The fluids of interest are preferably those related to dialysis, including hemodialysis and peritoneal dialysis. In a preferred embodiment, the fluids are irradiated with monochromatic light, and one or more Raman spectra are detected as a result of the irradiation. The fluids may be irradiated within the dialysis tubing itself, or removed from the dialysis tubing and irradiated in a separate chamber. The Raman spectra of one or more target analytes of a dialysis patient may be followed over time or compared to one or more reference spectra, thereby providing information on the health of dialysis patients.

Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

Abstract: A system for wirelessly obtaining physiological data from a subject includes a sensor patch and a separate electronics package. The sensor patch is disposed on and adheres to the subject, and includes a first part of a releasable electrical connector. An electronics package includes a second part of the first releasable electrical connector, which is used to physically and electrically connect the electronics package to the sensor patch. The electronics package includes a flexible substrate, with shells set on this substrate. The shells enclose the electronics. The shells are connected by a flexible circuit board. Analog front end circuitry is placed in one shell, while the wireless transceiver is placed in the other shell.

Abstract: An agent device transmits certain data, which is used for generating display data, of data relating to a plurality of pieces of operation data collected from an instrument to a computation server device. A service broker device relays certain data transmitted from the agent device to the server device. The server device generates display data on the basis of certain data relayed by the service broker device.

Abstract: A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.

Abstract: In an example embodiment, an optical communication system includes an implantable optical transmitter and an external optical receiver. The transmitter includes a housing having one or more drivers, plural light emitting sources, and an optical element arranged therein. Each driver converts a digital data signal into modulation signals to drive the sources. Each source generates a light beam in response to a corresponding modulation signal, each light beam contributing to form a single optical signal. The optical element directs the light beams to exit the housing such that a peak position of light intensity of each light beam is separated from a corresponding peak position of light intensity of an adjacent light beam by at least a first distance and less than a second distance. The optical receiver includes at least one photodiode that detects light generated by the sources and generates a reconstructed data signal.

Abstract: The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor measurements and reference readings may be used to estimate a relationship between sensor measurements and blood glucose concentration. Such sensor measurements may be weighted according to a decreasing function of uncertainty associated with sensor values.

Abstract: Method, device and system for providing consistent and reliable glucose response information to physiological changes and/or activities is provided to improve glycemic control and health management.

Abstract: A method for monitoring a health parameter in a person involves engaging an alignment feature of a health monitoring device with an alignment feature of an alignment element that is worn on the skin, transmitting radio waves from at least one transmit antenna of the health monitoring device below the skin surface of the person while the alignment feature of the health monitoring device is engaged with the alignment feature of the alignment element that is worn by the person, receiving radio waves on a two-dimensional array of receive antennas of the health monitoring device while the alignment feature of the health monitoring device is engaged with the alignment feature of the alignment element that is worn by the person, generating digital data that corresponds to the received radio waves, and determining a value that is indicative of a health parameter of the person in response to the digital data.

Abstract: An apparatus with a first photodetector and a second photodetector is provided. The apparatus is configured to receive light, and the first photodetector is configured to detect a first portion of the light. The first photodetector and the second photodetector are in a stacked arrangement and the apparatus is configured to pass a second portion of the light through the first photodetector to the second photodetector. The apparatus further includes an optical blocking filter configured to filter the second portion of the light prior to the second portion of the light arriving at the second photodetector.

Abstract: A system for non-invasively measuring an analyte in a vehicle driver and controlling a vehicle based on a measurement of the analyte. At least one solid-state light source is configured to emit different wavelengths of light. A sample device is configured to introduce the light emitted by the at least one solid-state light source into tissue of the vehicle driver. One or more optical detectors are configured to detect a portion of the light that is not absorbed by the tissue of the vehicle driver. A controller is configured to calculate a measurement of the analyte in the tissue of the vehicle driver based on the light detected by the one or more optical detectors, determine whether the measurement of the analyte in the tissue of the vehicle driver exceeds a pre-determined value, and provide a signal to a device configured to control the vehicle.

Abstract: A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra.

Abstract: Methods and systems for providing therapy related data management are provided. The subject systems include one or more device components, and at least one memory storage unit and at least one data storage unit associated with such one or more device components. The device components may include one or more of an analyte monitoring system, a fluid delivery device and a remote terminal. The subject methods include use of the subject systems to optimize treatment of a patient.

Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.