Glucose Patents (Class 600/316)
  • Patent number: 10314539
    Abstract: Provided are apparatuses for and methods of measuring a biological signal. The biological signal measuring apparatus includes reference point sensors configured to detect signals detected from at least two reference marks on a surface of a subject and a biological signal measuring position detector configured to generate information about a biological signal measuring position based on the signals detected from the at least two reference marks. The biological signal measuring apparatus measures the biological signal according to the information about the biological signal measuring position.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 11, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventor: Juneyoung Lee
  • Patent number: 10278591
    Abstract: Blood glucose measurement methods and apparatuses are provided using multiple body signals. The methods and apparatuses are employed to estimate blood glucose in a noninvasive manner by using a change in the absorbance of glucose according to a blood glucose level and to correct the estimated blood glucose using different types of blood glucose measurement methods. The blood glucose measurement apparatus includes a main body worn on a human body, a first light source provided on an inner surface of the main body, a second light source provided on the inner surface of the main body, a light receiver configured to receive light from the first light source and the second light source, and a calculator configured to calculate a glucose level in blood based on an amount of light received by the light receiver and configured to measure blood glucose.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: May 7, 2019
    Assignee: HUINNO CO., LTD.
    Inventor: Yeong Joon Gil
  • Patent number: 10226181
    Abstract: An object information acquiring apparatus comprises a light irradiation unit configured to irradiate lights having different wavelengths respectively; an acoustic wave receiving unit configured to receive an acoustic wave by each of the lights having different wavelengths respectively, and convert into an electric signal that corresponds to each of the lights having different wavelengths; a characteristic information acquiring unit configured to acquire characteristic distribution related to each position in the object based on the electric signal; a statistics acquiring unit configured to acquire a histogram from the characteristic distribution; and an image information acquiring unit configured to acquire image information causing a display device to display the characteristic distribution in the object and the histogram.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 12, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Takuji Oishi
  • Patent number: 10223769
    Abstract: A display device includes a first storage unit and a display chip. The first storage unit stores first extended display identification data comprising a plurality of first preset parameters. The display chip includes a control unit. The control unit provides at least one second preset parameter to replace a part of the first preset parameters in the first extended display identification data in response to a control signal and thereby generate second extended display identification data. The display chip issues a notification signal to notify the display signal providing device to read the second extended display identification data in response to a generation of the second extended display identification data. The display signal providing device provides a first display signal compatible with the second extended display identification data to the display device after reading the second extended display identification data. An extended display identification data replacement method is also provided.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: March 5, 2019
    Assignees: Qisda (Suzhou) Co., Ltd., Qisda Corporation
    Inventor: Chia-Hsiung Kuo
  • Patent number: 10215642
    Abstract: A system and method for detection of a target object/material includes identifying a polarimetric signal for a plurality of aspect angles. One/two-dimensional Mueller matrix image or one/two-dimensional Stokes vector image can be processed using power spectral analysis, wavelet and fractal analysis for further image, having increased discrimination with reduced false-ratio. In addition, each of the angular polarization states due to their association with a particular aspect angle are then cross-correlated to generate a two-dimensional image that relates the level of correlation with the aspect angle. Finally, the output information, including statistical parameters are fed to the input of a neural-fuzzy network for further optimization and image enhancement.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: February 26, 2019
    Assignee: The University of Akron
    Inventor: George C. Giakos
  • Patent number: 10213126
    Abstract: A system including a detector array configured to receive electromagnetic (EM) radiation from a target object, the detector array having one or more detectors is disclosed. The system also includes a readout integrated circuit and one or more processors. The readout integrated circuit has a circuit comprising a number of detector boundary selection components, each one of the number of detector boundary selection components configured to select or adjust a detector boundary from least one of a sub-column boundary or an adjustable boundary.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: February 26, 2019
    Assignee: Raytheon Company
    Inventors: Matthew D. Chambers, John L. Vampola, Micky Harris
  • Patent number: 10188334
    Abstract: Methods, devices, systems, and computer program products are provided to improve sensitivity calibration of an in vivo analyte sensor and usability of an associated analyte monitoring system. In certain embodiments, methods are provided that improve the user experience of using an analyte monitoring system. Certain embodiments of the present disclosure include features that reduce the amount of calibration or re-calibration performed by the analyte monitoring system. More specifically methods of using a suspect calibration attempt to avoid having to recalibrate by adjusting the calibration or mitigating effects of sensor signal attenuation that caused the calibration attempt to be suspect are provided. Additional features are disclosed.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: January 29, 2019
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Erwin Satrya Budiman, Gary Alan Hayter
  • Patent number: 10159412
    Abstract: The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: December 25, 2018
    Assignee: Cercacor Laboratories, Inc.
    Inventors: Marcelo M. Lamego, Massi Joe E. Kiani, Jeroen Poeze, Cristiano Dalvi, Sean Merritt, Hung Vo, Gregory A. Olsen, Ferdyan Lesmana
  • Patent number: 10155087
    Abstract: A biosensor detects a medication applied to an upper epidermal layer of skin of a user. The biosensor obtains at periodic intervals a concentration level of the medication in the upper epidermal layer of skin and surrounding tissue of the user. The biosensor may also detect the concentration level of the medication in an arterial blood flow of the patient or obtain a concentration level of a substance in the arterial blood flow, wherein the concentration level of the substance correlates to a first concentration level of the medication. The biosensor may determine an absorption rate of the medication in the upper epidermal layer of skin and surrounding tissue and in an arterial blood flow of the patient from the detected concentration levels of the medication obtained at the periodic intervals.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: December 18, 2018
    Assignee: SANMINA CORPORATION
    Inventors: Robert Steven Newberry, Matthew Rodencal
  • Patent number: 10156474
    Abstract: A transmission spectroscopy device can direct light into a sample, and determine properties of the sample based on how much light emerges from the sample. The device can use a cell to contain the sample, so that the size of the cell defines the optical path length traversed by light in the sample. To ensure accuracy in the measurements, it is beneficial to calibrate the device by measuring the size of the cell periodically or as needed. To measure the size of the cell, the device can perform a transmission spectroscopy measurement of a known substance, such as pure water, to produce a measured absorbance spectrum of the known substance. The device can subtract a known absorbance spectrum of the known substance from the measured absorbance spectrum to form an oscillatory fringe pattern. The device can determine the size of the cell from a period of the fringe pattern.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: December 18, 2018
    Assignee: Bentley Instruments, Inc.
    Inventors: Craig Parsons, Henrik Lyder
  • Patent number: 10133065
    Abstract: The present invention relates to a heads up display system for a vehicle interior that includes a light modifying panel configured to cyclically transition between a substantially light transmissive state that facilitates light passage through the light modifying panel and a partially reflective state that facilitates light reflection toward a occupant of a vehicle. The heads up display system also includes a pulsating light source configured to cyclically project an image onto the light modifying panel, and a controller configured to control the pulsating light source and the light modifying panel so that the image is projected onto the light modifying panel while the light modifying panel is in the partially reflective state.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: November 20, 2018
    Assignee: Visteon Global Technologies, Inc.
    Inventors: Andrew K. Ruiter, Lawrence Robert Hamelink
  • Patent number: 10130296
    Abstract: An apparatus for noninvasively measuring a bio-analyte including a metering device configured to obtain at least one of light and electrical information representative of an amount of fibrous protein from skin of a subject; and a processor configured to determine information representative of an amount an analyte present in blood of the subject based on the obtained information representative of an amount of the fibrous protein.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: November 20, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Joonhyung Lee, Sangkyu Kim, Seongho Cho
  • Patent number: 10080842
    Abstract: An integrated circuit includes circuitry to control a process. The process includes adjusting fuzzy-logic control parameters based on received and retrieved blood glucose-related data, predicting blood glucose levels based on the received blood-glucose-related data, and generating control signals to control dispensing of insulin based on the received blood glucose-related data and the fuzzy-logic control parameters. The process may include predicting blood glucose levels based on the retrieved blood glucose-related data. The process may include transitioning between a post-meal correction protocol and a fasting protocol. The process may include transitioning from a post-meal correction protocol to a fasting protocol when a fasting criteria is satisfied.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: September 25, 2018
    Assignee: Dose Safety
    Inventors: Robert C. Kircher, Jr., Richard S. Mauseth, Jason N. Bishop, Donald P. Matheson, Suray Bhatia, Jeff A. Bilmes
  • Patent number: 10076356
    Abstract: A subcutaneous access device has a skin attachment plate coated with an adhesive layer. The skin attachment plate is moveably linked by a retraction mechanism to a needle support with fixedly positioned needles. In the ready-to-use position the skin attachment plate is spaced away from the needle support and covers the fixedly positioned needles. Subcutaneous insertion of the needles is effected by attachment of the skin attachment plate with the adhesive layer to the skin and releasing the retraction mechanism, thus triggering the pulling of the attached skin with high velocity against the tip of the needles.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: September 18, 2018
    Assignee: PharmaSens AG
    Inventors: Paul Hadvary, Hansjorg Tschirky
  • Patent number: 10052497
    Abstract: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in in vivo and in vitro environments).
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: August 21, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, David J. Mishelevich, M. Bret Schneider
  • Patent number: 10028659
    Abstract: A system for measuring and/or monitoring an analyte present in interstitial fluid in skin is provided. The system includes a substrate that may be implanted into the skin and a reader device. The substrate includes a sensor comprising aptamer conjugates and is configured to obtain one or more measurements related to at least one analyte in interstitial fluid. The reader device is configured to detect the analyte in interstitial fluid via interaction with the substrate.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: July 24, 2018
    Assignee: Verily Life Sciences LLC
    Inventors: Jerrod Joseph Schwartz, Jason Donald Thompson, Vikram Singh Bajaj
  • Patent number: 10019783
    Abstract: A test piece analyzer and test piece analyzing method which is compact and capable of analyzing a test piece even when mounted obliquely is provided. The test piece analyzer is configured by a test piece holder 11 that includes a mounting part MP for mounting a test piece provided with reagent pads, and an imaging unit 20, wherein the imaging unit 20 is configured to sequentially image the test piece along the longitudinal direction of the mounting part.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 10, 2018
    Assignee: SYSMEX CORPORATION
    Inventor: Takashi Kusuhara
  • Patent number: 10004398
    Abstract: In various embodiments, a device for determining a condition of an organ of either a human or an animal may be provided. The device may include a first optical source and a second optical source. The device may also include a detector. The device may additionally include a lens system. The device may further include a switching mechanism configured to switch between an optical examination mode and a Raman mode. The lens system during the optical examination mode may be configured to direct a first light emitted from the first optical source. The lens system during the Raman mode may be configured to direct a second light emitted from the second optical source. The lens systems during the Raman mode may be further configured to direct a third light to the detector.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 26, 2018
    Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Quan Liu, Roger Beuerman, Shuo Chen
  • Patent number: 10004399
    Abstract: A spectrometer includes an illuminating section; a receiving section configured to detect radiation reflected from an object including an optically inhomogeneous scattering medium; a hardware section configured to obtain a solution of an inverse problem to reconstruct an absorption spectrum of the optically inhomogeneous scattering medium, wherein the illuminating section includes at least one light-emitting diode source, a radiation spectral curve of which is divided, by at least two spectral filters having different spectral transmission curves, into at least two spectral regions, to form an equivalent radiation spectrum from at least two spectral sources, and wherein the hardware section applies the solution of the inverse problem based on information about a spectral content of the radiation of the illuminating section, a signal obtained in a form of a response from the optically inhomogeneous scattering medium, and a spectral sensitivity curve of the receiving section.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: June 26, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Alexey Grigor'evich Anikanov, Sergey Vasil'evich Afanasyev, Vladislav Vladimirovich Druzhin, Alexander Victorovich Morozov
  • Patent number: 9999728
    Abstract: An electronic controller for an insulin infusion device includes at least one processor device and at least one memory element that cooperate to provide a processor-implemented closed-loop initiation module. The initiation module is operated to obtain a most recent calibration factor for a continuous glucose sensor, the most recent calibration factor representing a first conversion value applicable to convert a first sensor value to a first blood glucose value. The initiation module also obtains a prior calibration factor for the sensor, and calibration timestamp data for the most recent calibration factor and the prior calibration factor. The initiation module regulates entry into a closed-loop operating mode of the insulin infusion device, based on the most recent calibration factor, the prior calibration factor, and the calibration timestamp data.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: June 19, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Neha J. Parikh, Anirban Roy, Desmond Barry Keenan, John J. Mastrototaro, Benyamin Grosman
  • Patent number: 9989490
    Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 5, 2018
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Ning Yang, Raghavendhar Gautham, Bradley C. Liang, Rajiv Shah
  • Patent number: 9949673
    Abstract: A subcutaneous sensor system includes a sensor, a plurality of reservoirs, a plurality of pumps, a mixer provided with a plurality of mixer inlets and a mixer outlet, and a controller having an input coupled to the sensor output and a plurality of control outputs coupled to the plurality of pumps and the mixer. In certain embodiments, the system further includes an enclosure for the reservoirs, the pumps, the mixer and the controller, e.g. in the form of a skin patch or in the form of an implantable enclosure. In certain embodiments, the sensor is external to the enclosure and implanted beneath the skin tissue.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: April 24, 2018
    Assignee: MAXIM lNTEGRATED PRODUCTS, INC.
    Inventor: John F. Di Cristina
  • Patent number: 9931068
    Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the analyte indicator, a membrane covering at least a portion of the analyte indicator, and/or one or more drug eluting polymer matrices, which may be external to or within the sensor housing.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: April 3, 2018
    Assignee: Senseonics, Incorporated
    Inventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
  • Patent number: 9907491
    Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: March 6, 2018
    Assignee: Medtronic Minimed, Inc.
    Inventors: Xialong Li, Brian T. Kannard, Rajiv Shah
  • Patent number: 9883790
    Abstract: A medical luminaire for photodynamic diagnosis. The medical luminaire including: a broad-band lamp for generating broad-band background light; a semiconductor lamp for generating short-wave excitation light, wherein the semiconductor lamp comprises a laser diode, the light from which is fed alternatively or additionally into a light path of the broad-band lamp, and a light fiber bundle for transporting the light, wherein the excitation light is transported in a partial bundle.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: February 6, 2018
    Assignee: OLYMPUS WINTER & IBE GMBH
    Inventor: Michael Wolter
  • Patent number: 9874474
    Abstract: A biometric sensor that measures biometric information and a biometric analysis system including the biometric sensor are provided. The biometric sensor may include: a light source configured to emit light toward a region of interest of an object under examination, the light being diffused at the region of interest; a collimator that includes a though-hole and is configured to collimate the diffused light received from the region of interest; and a spectrometer configure to analyze the diffused light transmitted by the collimator.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: January 23, 2018
    Assignees: SAMSUNG ELECTRONICS CO., LTD., IMEC TAIWAN
    Inventors: Seongho Cho, Chaokang Liao, Dongho Kim
  • Patent number: 9869585
    Abstract: Systems and techniques for optical spectrometer detection using, for example, IR spectroscopy components and Raman spectroscopy components are described. For instance, a system includes a first electromagnetic radiation source configured to illuminate a sample with a first portion of electromagnetic radiation in a first region of the electromagnetic spectrum (e.g., an IR source) and a second electromagnetic radiation source configured to illuminate a sample with a second portion of electromagnetic radiation in a second substantially monochromatic region of the electromagnetic spectrum (e.g., a laser source). The system also includes a detector module configured to detect a sample constituent of a sample by analyzing a characteristic of electromagnetic radiation reflected from the sample associated with the first electromagnetic radiation source and a characteristic of electromagnetic radiation reflected from the sample associated with the second electromagnetic radiation source.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: January 16, 2018
    Assignee: Smiths Detection Inc.
    Inventors: David W. Schiering, Maxim Frayer, Peng Zou
  • Patent number: 9829378
    Abstract: A transmission spectroscopy device can direct light into a sample, and determine properties of the sample based on how much light emerges from the sample. The device can use a cell to contain the sample, so that the size of the cell defines the optical path length traversed by light in the sample. To ensure accuracy in the measurements, it is beneficial to calibrate the device by measuring the size of the cell periodically or as needed. To measure the size of the cell, the device can perform a transmission spectroscopy measurement of a known substance, such as pure water, to produce a measured absorbance spectrum of the known substance. The device can subtract a known absorbance spectrum of the known substance from the measured absorbance spectrum to form an oscillatory fringe pattern. The device can determine the size of the cell from a period of the fringe pattern.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: November 28, 2017
    Assignee: Bentley Instruments, Inc.
    Inventors: Craig Parsons, Henrik Lyder
  • Patent number: 9814414
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 14, 2017
    Assignee: DexCom, Inc.
    Inventors: Mark Brister, Paul V. Neale, Sean Saint, James R. Petisce, James Patrick Thrower, Apurv Ullas Kamath, Daniel S. Kline, John A. Guerre, Daniel Shawn Codd, Thomas F. McGee, David Michael Petersen
  • Patent number: 9811638
    Abstract: A glycemic control system includes a physician processor, remote processor, and a portable telephone having a data input mechanism, a display, and an internal processor for bi-directional communication with the physician's processor and the remote processor. A patient inputs data to the internal processor responsive to input from the physician's processor and then transmits the information to the remote processor where an optimized number of units to be administered is sent back and displayed on the portable telephone.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: November 7, 2017
    Assignee: Aseko, Inc.
    Inventors: Robert C. Booth, Robert E. Fischell
  • Patent number: 9801584
    Abstract: A method is provided for determining contact of a sensor with a patient's tissue. The method comprises comparing the intensity of detected light at a first wavelength to a threshold, wherein the first wavelength is not used to determine a physiological characteristic of the patient, and determining if the sensor is in contact with the patient's tissue based on the comparison. In addition, a method is provided for determining the amount of light shunting during operation of the sensor. The method comprises comparing the intensity of detected light at a first wavelength to a threshold, wherein the first wavelength is not used to determine a physiological characteristic of the patient, and determining the amount of light shunting based on the comparison.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: October 31, 2017
    Assignee: Covidien LP
    Inventor: Clark R. Baker, Jr.
  • Patent number: 9797859
    Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods allow one to correct and/or compensate for confounding variables such as temperature before providing an analyte concentration. The measurement methods use response information from a test sequence having at least one DC block, where the DC block includes at least one excitation pulse and at least one recovery pulse, and where a closed circuit condition of an electrode system is maintained during the at least one recovery pulse. Information encoded in the at least one recovery pulse is used to correct/compensate for temperature effects on the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 24, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Scott E. Carpenter
  • Patent number: 9788763
    Abstract: Methods of exerting magnetic forces to separate magnetic particles disposed in a portion of subsurface vasculature using a wearable device are provided. The magnetic forces can act to attract, slow, speed, or otherwise influence the magnetic particles in various applications. In some examples, different magnetic forces are exerted on respective sets of magnetic particles to separate the respective sets of magnetic particles. In some examples, similar magnetic forces are exerted on sets of magnetic particles, and separation of the sets of magnetic particles is related to properties of the sets of magnetic particles and/or of the environment of the sets of magnetic particles. In some embodiments, the magnetic particles are configured to bind to an analyte of interest. The separation of the magnetic particles can enable detection of one or more properties of the analyte, modification of the analyte, and/or extraction of the analyte bound to the magnetic particles.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: October 17, 2017
    Assignee: Verily Life Sciences LLC
    Inventors: Vasiliki Demas, Vikram Singh Bajaj
  • Patent number: 9763608
    Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802?, 802? formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 19, 2017
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Robert Boock, Paul V. Neale, Sebastian Böhm, Matthew Wightlin, Jack Pryor, Jason Mitchell, Jeff Jackson, Kaushik Patel, Antonio C. Llevares
  • Patent number: 9724028
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: August 8, 2017
    Assignee: DexCom, Inc.
    Inventors: James H. Brauker, Apurv Ullas Kamath
  • Patent number: 9713441
    Abstract: An optical rotation measurement method includes causing measurement light of a predetermined polarization to be incident on a subject from an incident direction that is a non-right angle to the subject, discriminating an optical rotation reflecting component of the predetermined polarization from reflected light that is reflected in a different direction to the incident direction of the subject, and measuring the optical rotation based on the discrimination result.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: July 25, 2017
    Assignee: Seiko Epson Corporation
    Inventors: Akira Ikeda, Kazuhiro Nishida
  • Patent number: 9662004
    Abstract: An apparatus for non-invasive glucose monitoring includes a first light source for emitting at least one ray of first light; a first beam splitter with a focusing function; a set of photo detectors for measuring optical rotatory distribution (ORD) information and absorption energy information of the first light reflected from the eyeball and transmitted through the first beam splitter to the set of photo detectors, and the first light emitted from the first light source being transmitted to the set of photo detectors by the first beam splitter and the eyeball to form an optical path; a processing unit receiving and processing the ORD information and the absorption energy information to obtain glucose information; and an eye positioning device including a second beam splitter disposed on the optical path between the first beam splitter and the eyeball and a camera for receiving image information transmitted from the second beam splitter.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: May 30, 2017
    Assignee: Taiwan Biophotonic Corporation
    Inventors: Yu-Tang Li, Chang-Sheng Chu, Chih-Hsun Fan, Shuang-Chao Chung, Ming-Chia Li, Jyh-Chern Chen, Kuo-Tung Tiao
  • Patent number: 9649056
    Abstract: Embodiments provide sensors, such as implantable sensors, and methods of producing such sensors. An implantable sensor may include a base, one or more chambers, and one or more sensor reagents. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be at least partially implanted into the dermis of an animal. One or more of the sensor reagents may emit light or exhibit a color change in response to the presence of a target analyte or reaction product thereof. The response may be detected and analyzed by the user or by a reader device to determine the target analyte concentration.
    Type: Grant
    Filed: December 29, 2012
    Date of Patent: May 16, 2017
    Assignee: Optica, Inc.
    Inventor: Mihailo V. Rebec
  • Patent number: 9641239
    Abstract: Biometric monitoring devices, including various technologies that may be implemented in such devices, are discussed herein. Additionally, techniques, systems, and apparatuses are discussed herein for utilizing two different Bluetooth communications interfaces, one that provides Bluetooth classic (base rate/enhanced data rate) communications functionality and one that provides Bluetooth low-energy communications functionality, in a common device. The techniques, systems, and apparatuses may elect to use a particular Bluetooth interface based on various criteria.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: May 2, 2017
    Assignee: Fitbit, Inc.
    Inventors: Heiko Gernot Albert Panther, James Park
  • Patent number: 9636457
    Abstract: An integrated drug delivery and biosensor (IDDB) system is implemented on a patch or arm band. The drug delivery system includes needles adapted to pierce the skin and direct injection of a predetermined dosage of medication through the needles into the epidermis of the skin of a patient. The integrated biosensor monitors absorption of the medication into the epidermis of the skin of the patient and may also monitor concentration of the medication or other relevant substances in arterial blood flow of the patient. The integrated biosensor may also monitor a patient's vitals in response to the medication. The integrated biosensor may then alter dosage or frequency of administration of dosages or even halt a dosage of medication in response to the patient's vitals or absorption of the medication.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: May 2, 2017
    Assignee: SANMINA CORPORATION
    Inventors: Robert Steven Newberry, Matthew Rodencal
  • Patent number: 9610033
    Abstract: An exemplary sensor chip includes a substrate, a metal pattern, a proximate substance, and a light shielding layer. The metal pattern is on the substrate. The proximate substance is on or near the metal pattern. The light shielding layer is provided on the substrate so as to cover the metal pattern and the proximate substance. The light shielding layer is a layer that blocks the excitation light from going into the proximate substance, and is made of a substance which becomes degraded inside a subject.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: April 4, 2017
    Assignee: PANASONIC CORPORATION
    Inventors: Yasuaki Okumura, Tatsurou Kawamura, Masaru Minamiguchi, Masahiko Shioi
  • Patent number: 9560999
    Abstract: A glucose tolerance analyzer comprising: an accepting section configured to accept inputs of information regarding a type of food or drink ingested by a subject, information regarding an intake amount of the food or drink, and information regarding an amount of glucose in the subject after the ingestion of the food or drink; an output section configured to output an analysis result of glucose tolerance; and a controller configured to: calculate a reference value for analyzing glucose tolerance of the subject based on the accepted information regarding the type of the food or drink ingested by the subject and the information regarding the intake amount of the food or drink, and based on a predetermined index regarding blood glucose increase due to food or drink; analyze the glucose tolerance of the subject based on the accepted information regarding the amount of glucose and based on the calculated reference value; and control the output section to output an obtained analysis result as an analysis result of gl
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: February 7, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Toshiyuki Sato, Seiki Okada, Takeyoshi Fujiwara, Mariko Yuno, Shigenobu Egawa
  • Patent number: 9558325
    Abstract: Methods and apparatus for analyte level estimation are provided for filtering measurement data. In an embodiment, a present predicted analyte level estimate is determined. A present corrected analyte level estimate is determined based at least in part on the determined present predicted analyte level estimate and a received present monitored analyte measurement data. One or more of the medication infusion rate or the received present monitored analyte measurement data are filtered using a rate variance filter, wherein when the medication infusion rate exceeds a predetermined threshold level, the rate variance filter is adjusted from a predetermined setting to a modified setting to be responsive to changes in the present monitored analyte measurement data after a predetermined time period lapses.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: January 31, 2017
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Gary Alan Hayter, Erwin Satrya Budiman
  • Patent number: 9551656
    Abstract: A method of processing diffuse spectrum data may include: obtaining diffuse spectrum data of a medium to be detected at one or more first radial positions; and determining optical information caused by substantially only a variation in scattering characteristic of the medium to be detected and/or optical information caused by substantially only a variation in absorption characteristic of the medium to be detected at one or more second radial positions from the obtained diffuse spectrum data.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: January 24, 2017
    Assignee: TIANJIN SUNRISE TECHNOLOGIES DEVELOPMENT CO., LTD.
    Inventors: Kexin Xu, Jin Liu
  • Patent number: 9539329
    Abstract: A hydrogel-lightguide based sensory system susceptible to a stimulus signal produced by ambient and stimulating sensory cells embedded in a hydrogel body of the system. Sensory cells generate an optical signal (in response to a user-defined triggering with excitation light or, alternatively, due to bioluminescence) the properties of which, determined based on detection of such signal with an optical detector device, provide characterization of the stimulus and information required for user-defined activation of emitter cells encapsulated in the hydrogel. When activated, emitter cells generate matter and/or light directed to interact with the ambient.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: January 10, 2017
    Inventors: Seok-Hyun Yun, Myunghwan Choi
  • Patent number: 9498157
    Abstract: A method for calibrating detectors of a self-contained, tissue oximetry device includes emitting light from a light source into a tissue phantom, detecting in a plurality of detectors the light emitted from the light source, subsequent to reflection from the tissue phantom, and generating a set of detector responses by the plurality of detectors based on detecting the light emitted from the light source. The method further includes determining a set of differences between the set of detector responses and a reflectance curve for the tissue phantom, and generating a set of calibration functions based on the set of differences. Each calibration function in the set of calibration functions is associated with a unique, light source-detector pair. The method further includes storing the set of calibration function in a memory of the self-contained, tissue oximetry device.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: November 22, 2016
    Assignee: ViOptix, Inc.
    Inventors: Kate LeeAnn Bechtel, Brian Wilfley
  • Patent number: 9483619
    Abstract: A glycemic control system includes a physician processor, remote processor, and a portable telephone having a data input mechanism, a display, and an internal processor for bi-directional communication with the physician's processor and the remote processor. A patient inputs data to the internal processor responsive to input from the physician's processor and then transmits the information to the remote processor where an optimized number of units to be administered is sent back and displayed on the portable telephone.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: November 1, 2016
    Assignee: Aseko, Inc.
    Inventors: Robert C. Booth, Robert E. Fischell
  • Patent number: 9480426
    Abstract: A process is described for testing a biomedical property of an internal tissue of a patient. Optical energy emitted by an external source is transferred through a nail of the patient to an instrument device implanted beneath the nail. A portion of the transferred optical energy is converted to electrical power for driving components of the implanted instrument. Using the electrical power, a characteristic of the internal tissue associated with the measurement of the biomedical property is sensed and an optical signal based on the sensed characteristic is transmitted through the nail to an external data reader.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: November 1, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Aditya Rajagopal, Axel Scherer, Akram Sarwat Sadek
  • Patent number: 9456772
    Abstract: A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: October 4, 2016
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Anthony J. Webb
  • Patent number: 9459203
    Abstract: A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: October 4, 2016
    Assignee: Zyomed, Corp.
    Inventors: Sandeep Gulati, Timothy L. Ruchti, William Van Antwerp, John L. Smith