Measuring Pressure In Heart Or Blood Vessel Patents (Class 600/485)
  • Patent number: 10806951
    Abstract: The invention provides compositions featuring TRP-4 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell type of interest, and methods for inducing the activation of the TRP-4 polypeptide in neurons and other cell types using ultrasound.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: October 20, 2020
    Assignee: Salk Institute for Biological Studies
    Inventors: Sreekanth H. Chalasani, Stuart Ibsen
  • Patent number: 10779765
    Abstract: The disclosure includes a system for sensing physiologic data. The system can include a flexible configured to wrap around a finger of a user, a first electrode coupled to the flexible strap, and a second electrode coupled to the flexible strap. The system can also include a sensor housing comprising at least one sensor configured to detect physiologic data from the finger and a data receiving module communicatively coupled to the first electrode, the second electrode, and the at least one sensor. The data receiving module can be configured to receive physiologic data from the at least one sensor.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: September 22, 2020
    Assignee: Aclaris Medical, LLC
    Inventors: Mark Bly, Andrew Radtke
  • Patent number: 10772571
    Abstract: A system for monitoring blood pressure of a subject includes a primary system for determining a first blood pressure and a corrective system. The corrective system includes a cuff configured to be operated in an inflation phase and a deflation phase, a sensor array which produces inflation and deflation phase output signals, and a processor. The processor is configured to a) determine first and second output values from the inflation phase output signal and b) determine third and fourth output values from the deflation phase output signal. The processor is also configured to determine a correction applicable to the first blood pressure. The correction is a function of the first, second, third and fourth output values.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: September 15, 2020
    Assignee: Welch Allyn, Inc.
    Inventors: Matthew J. Kinsley, David E. Quinn
  • Patent number: 10765791
    Abstract: The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: September 8, 2020
    Assignee: ABIOMED, INC.
    Inventors: Christian Moyer, Scott C. Corbett, Ahmad El Katerji, David Weber
  • Patent number: 10765326
    Abstract: The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the ‘Composite Method’, is carried out with a body-worn monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor. A network of body-worn sensors, typically placed on the patient's right arm and chest, connect to the body-worn monitor and measure time-dependent ECG, PPG, accelerometer, and pressure waveforms. The disposable sensors can include a cuff that features an inflatable bladder coupled to a pressure sensor, three or more electrical sensors (e.g. electrodes), three or more accelerometers, a temperature sensor, and an optical sensor (e.g., a light source and photodiode) attached to the patient's thumb.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: September 8, 2020
    Assignee: SOTERA WIRLESS, INC.
    Inventors: Matt Banet, Marshal Dhillon, Devin McCombie
  • Patent number: 10765328
    Abstract: A method and system for determining anaerobic threshold intensity (AnT) of a user in a freely performed physical exercise. A physiological response of a user is measured by heart rate and measured heart rate values are recorded as heart rate data. An external workload values are recorded and are each associated with one measured heart rate values to form a plurality of data points. The data points are filtered to form accepted data points, which are classified within a plurality of heart rate segments representing a heart rate within an anaerobic threshold (AnT) of the user. A data point with highest probability is stored for each segment. A first probability factor for each accepted data point is calculated. The calculated first probability factor is compared to a stored probability factor in each segment, and the higher probability factor is retained. AnT is calculated using the stored probabilities in each segment.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: September 8, 2020
    Assignee: Firstbeat Analytics Oy
    Inventors: Sami Saalasti, Kaisa Hämäläinen, Tero Myllymäki
  • Patent number: 10758143
    Abstract: Embodiments disclose a blood pressure parameter detection method. The method includes: detecting, by user equipment UE, an electrocardiogram ECG signal of a user by using a first ECG contact and a second ECG contact that are connected to an ECG detection circuit of the UE; when determining that the detected ECG signal matches a pre-stored reference ECG signal, enabling, by the UE, a photoplethysmogram PPG detection circuit, and detecting a PPG signal of the user by using a PPG detection point connected to the PPG detection circuit; and when determining that the detected PPG signal matches a pre-stored reference PPG signal, enabling, by the UE, a blood pressure detection application, and processing the detected ECG signal and the detected PPG signal by using the blood pressure detection application to obtain a blood pressure parameter of the user.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: September 1, 2020
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Yonglin Gui, Bo Yang, Qizhi Zhan, Honggang Li, Zexu Qian
  • Patent number: 10758130
    Abstract: A system configured to determine a characteristic of a patient includes a plurality of sensors, wherein each sensor of the plurality of sensors is configured to noninvasively determine a respective parameter of the patient, and wherein the parameter determined by each sensor is different from parameters determined by remaining sensors of the plurality of sensors. Such a system also includes a connector having a passage configured to direct pressurized fluid therethrough, wherein the plurality of sensors is connected to the connector.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: September 1, 2020
    Assignee: Welch Allyn, Inc.
    Inventors: Matthew D. Mullin, David E. Quinn, John A. Lane, Sean R. Karla, Michael J. Anson
  • Patent number: 10758111
    Abstract: Systems and methods are provided for controlling lateral movement of a medical capsule system. A capsule housing is configured to be inserted into an anatomical structure of a patient. The multichannel tether is coupled to a rear of the capsule and includes at least one liquid exhaust channel conveying liquid to the capsule housing. The plurality of liquid exhaust ports are positioned around an outer circumference of the capsule housing and each configured to controllably expel liquid laterally from the capsule housing at varying rates to affect lateral movement of the capsule housing.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 1, 2020
    Assignee: Vanderbilt University
    Inventors: Pietro Valdastri, Keith Obstein, Robert Caprara, Christopher Lyne, Federico Campisano, Gabrielmaria Scozzarro, Alexander Vartanian, William Jones, Christian Di Natali, Marco Beccani, Erdem Erdemir, Douglas R. Morgan
  • Patent number: 10750949
    Abstract: The present document describes a pressure guidewire. It comprises a shaft tube having a proximal section configured to provide pushability to the pressure guidewire; a middle section extending distally relative to the proximal section, the middle section comprising a cut pattern configured to provide greater flexibility in the middle section than the proximal section; and a sensor housing section extending distally relative to the middle section. The pressure guidewire further comprises an inner hypotube comprising a proximal end portion and a distal end portion, the inner hypotube positioned entirely radially inward of the shaft tube and within at least the middle section, the proximal end portion and the distal end portion of the inner hypotube being joined to the shaft tube; and a tip pressure sensor positioned in the sensor housing section.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: August 25, 2020
    Assignee: Opsens Inc.
    Inventor: Claude Belleville
  • Patent number: 10751004
    Abstract: A system having a processor obtain a digital hemodynamic data from a hemodynamic sensor, obtain one or more vital sign parameters characterizing vital sign data from the digital hemodynamic data, derive differential parameters based on the one or more vital sign parameters, generate combinatorial parameters using the one or more vital sign parameters and the differential parameters, determine a risk score corresponding to a probability of a future hypotension event for the living subject based on a weighted combination of a plurality of hypotension profiling parameters including the one or more vital sign parameters characterizing vital sign data, the differential parameters and the combinatorial parameters, and invoke a sensory alarm if the risk score satisfies a predetermined risk criterion.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: August 25, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Feras Al Hatib, Zhongping Jian, Sai Prasad Buddi
  • Patent number: 10743781
    Abstract: Disclosed is ischemic precondition treatment equipment and a use and method thereof for judging health condition of blood vessels. A gas way structure (4) is arranged inside a shell of ischemic precondition training treatment equipment. The gas way structure comprises a 5-way device (43). The 5-way device (43) is connected to a left gas pump (41), a right gas pump (42), a left solenoid valve (44), a right solenoid valve (45) and a release valve (48), respectively. The gas way structure (4) can rapidly bring a pressure of an armband airbag to the set pressure value in a short period of time, which is effective in relieving the patients' discomfort and pain when used. It is suitable for long-term use for training. In addition, it also can judge the health condition of blood vessels.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: August 18, 2020
    Inventor: Xunming Ji
  • Patent number: 10736517
    Abstract: A non-contact blood-pressure measuring device includes: an image acquiring section that acquires a skin image obtained by capturing skin of a user; a pulse-wave timing calculating section that calculates, as a pulse-wave timing, time information indicative of a time at which time-varying luminance in the skin image reaches a peak; a millimeter-wave acquiring section that acquires a signal of a radio wave reflected by the user; a heartbeat timing calculating section that calculates, as a heartbeat timing, time information indicative of a time at which a time-varying distance to the user obtained on the basis of the signal of the radio wave acquired by the millimeter-wave acquiring section reaches a peak; and a blood-pressure determining section that determines blood pressure of the user on the basis of a time difference between the pulse-wave timing and the heartbeat timing.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 11, 2020
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Mototaka Yoshioka, Jun Ozawa
  • Patent number: 10736520
    Abstract: A blood pressure measurement device is equipped with a pressing surface which is formed with an element array of plural pressure sensors arranged in one direction and an element array of plural pressure sensors arranged in the one direction, an air bag for pressing the pressing surface against a living body, a control unit for calculating blood pressure values in a radius artery on the basis of pressure pulse waves that are detected by the pressure sensors in a state that the pressing surface is pressed against the living body by the air bag, and a rotational drive unit for performing driving to rotate the pressing surface about each of axes that are perpendicular to a pressing direction of the air bag.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: August 11, 2020
    Assignees: OMRON HEALTHCARE Co., Ltd., Omron Corporation
    Inventors: Tsuyoshi Kitagawa, Shingo Yamashita, Toshihiko Ogura, Masayuki Fukutsuka, Daizo Oka, Naomi Matsumura, Kentaro Mori, Hiroyuki Kinoshita, Masayuki Wakamiya
  • Patent number: 10729337
    Abstract: The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said LVEDP or PCWP using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: August 4, 2020
    Assignees: The Johns Hopkins University, Boston Scientific Scimed Inc.
    Inventors: Qian Liu, Nichaluk Leartprapun, Jackline Wanjala, Soumyadipta Acharya, Andrew Bicek, Viachaslau Barodka, Umang Anand, Majd Alghatrif, David Kass, B. Westbrook Bernier, Chao-Wei Hwang, Peter Johnston, Trent Langston
  • Patent number: 10729338
    Abstract: The present application discloses a blood pressure measurement device, includes: a blood pressure measurement body configured to measure blood pressure based on photoplethysmogram (PPG); and a calibrator configured to measure blood pressure values based on Korotkoff sounds. The calibrator is further configured to provide initial calibration parameters to the blood pressure measurement body, and the blood pressure measurement body is further configured to collect an ECG signal and a PPG signal, calibrate a PPG parameter-blood pressure equation according to the initial calibration parameters, and calculate a blood pressure value according to the PPG parameter-blood pressure equation.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: August 4, 2020
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Guohe Wang, Hui Du
  • Patent number: 10733910
    Abstract: A method and system for estimating physiological heart measurements from medical images and clinical data disclosed. A patient-specific anatomical model of the heart is generated from medical image data of the patient. A patient-specific multi-physics computational heart model is generated based on the patient-specific anatomical model by personalizing parameters of a cardiac electrophysiology model, a cardiac biomechanics model, and a cardiac hemodynamics model based on medical image data and clinical measurements of the patient. Cardiac function of the patient is simulated using the patient-specific multi-physics computational heart model. The parameters can be personalized by inverse problem algorithms based on forward model simulations or the parameters can be personalized using a machine-learning based statistical model.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: August 4, 2020
    Assignee: Siemens Healthcare GmbH
    Inventors: Dominik Neumann, Tommaso Mansi, Sasa Grbic, Bogdan Georgescu, Ali Kamen, Dorin Comaniciu, Ingmar Voigt
  • Patent number: 10722177
    Abstract: A system for collecting data for assessment of cardiovascular function includes a plurality of monitoring devices coupled to different respective body parts. Each monitoring device is configured to measure a respective signal at the respective body part in response to cardiovascular activity. The respective signal includes a cardiovascular component attributable to the cardiovascular activity and an artifact component not attributable to the cardiovascular activity. When the monitoring devices measure the respective signals simultaneously over a same time period, the cardiovascular components are correlated, and the artifact components are not correlated.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: July 28, 2020
    Assignee: Verily Life Sciences LLC
    Inventors: Andrew Homyk, Jason Donald Thompson
  • Patent number: 10709383
    Abstract: A wrist-worn device heart-monitoring device is presented. The wrist-worn heart-monitoring device includes a radial tonometer configured to output a pressure signal indicating a pulse pressure wave at a user's wrist, two or more electrodes configured to output an electrical signal indicating a user's heart has been commanded to contract, and a microphone configured to output an audio signal indicating a closing of a user's aortic valve. The wrist-worn heart-monitoring device further includes a pulse transit time monitor configured to calculate a pre-ejection period of the user's heart based on at least the pressure, electrical, and audio signals, and calculate a pulse transit time based on at least the pre-ejection period, the pressure signal, and the electrical signal.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: July 14, 2020
    Assignee: MICROSOFT TECHNOLOGY LICNESING, LLC
    Inventors: Daniel Morris, Desney S. Tan, T. Scott Saponas, Shwetak N. Patel, Nicolas Villar, Gregory R. Smith, Sidhant Gupta, Gabriel Adam Cohn, David C. Kale, Sailaja Malladi, Ronald E. Paulsen
  • Patent number: 10702171
    Abstract: The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes. A wrist-worn device may include a plurality of sensors backed by a plurality of actuators. Subsets of the plurality of sensors may be selectively actuateable against a wrist of a user using one or more of the plurality of actuators. A preferred sensor and location may be identified based on pressure signals received from each of the sensors. In some embodiments, devices may use a fluid bladder coupled with piezoelectric film sensors. A fluid bladder pressure sensor may be used to calibrate the piezoelectric film signal to provide a static and dynamic pressure reading. In yet another embodiment, a mean arterial pressure may be calculated by processing a swept pressure signal obtained as a sensor is swept through different heights.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: July 7, 2020
    Inventors: Ravi Narasimhan, Zijing Zeng, Richard C. Kimoto, Erno Klaassen, Thomas J. Sullivan, Derek Park-Shing Young, Todd K. Whitehurst
  • Patent number: 10702672
    Abstract: A multi-lumen catheter can be used to measure pressure at multiple locations within the vasculature. The multi-lumen catheter can include multiple segments, such as a proximal portion, an intermediate portion, and a distal portion. A segment of a multi-lumen catheter may differ from another segment of the same multi-lumen catheter in radiodensity, hardness, and/or some other characteristic. Some multi-lumen catheters are designed to permit measurements of pressure in different lumens.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: July 7, 2020
    Assignee: Merit Medical Systems, Inc.
    Inventors: Fred Lampropoulos, Nicholas Accisano, III, Jim Mottola
  • Patent number: 10694960
    Abstract: Wearable pulse pressure wave sensing devices are presented that generally provide a non-intrusive way to measure a pulse pressure wave travelling through an artery using a wearable device. In one implementation, the device includes an array of pressure sensors disposed on a mounting structure which is attachable to a user on an area proximate to an underlying artery. Each of the pressure sensors is capable of being mechanically coupled to the skin of the user proximate to the underlying artery. In addition, there are one or more arterial location sensors disposed on the mounting structure which identify a location on the user's skin likely overlying the artery. A pulse pressure wave is then measured using the pressure sensor of the array closest to the identified location.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: June 30, 2020
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: T. Scott Saponas, Dan Morris, Nicolas Villar, Shwetak Patel, Greg R. Smith, Desney Tan, Orestis Vardoulis, Sidhant Gupta
  • Patent number: 10695004
    Abstract: Disclosed are systems and methods for using one or more light sources and associated photodetectors to determine different physiological parameters of a subject based on the subject's activity state. A processor may, for example, be configured to determine, based at least in part on data received from an accelerometer at a first time, that a first physiological parameter of the subject is to be determined, to cause the light source(s) to operate in a first manner and process signals from the photodetector(s) to determine the first physiological parameter, to determine, based at least in part on data received from the accelerometer at a second time, that a second physiological parameter of the subject is to be determined, and to cause the light source(s) to operate in a second manner and process signals from the photodetector(s) to determine the second physiological parameter.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: June 30, 2020
    Assignee: LumiraDX UK, Ltd.
    Inventors: Paul J. Gaudet, Thomas J. Quinlan, III, Jerry Zhang, Norbert Ohlenbusch, Thomas P. Blackadar, David P. Monahan
  • Patent number: 10694959
    Abstract: The present invention provides an image based blood pressure monitoring method, comprising: acquiring at least a human image information of at least a human skin area; according to the human image information to locate at least a ROI; extracting the human image information of the ROI, and calculate; filtering the average value of the human image information; monitoring the filtered signal; calculating an image pulse transmit time of the filtered signal, and calculating an inter-beat interval of the filtered signal; and employ the specific prediction model, to calculate a systolic pressure value and a diastolic pressure value.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: June 30, 2020
    Assignee: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: Bing-Fei Wu, Po-Wei Huang, Chun-Hao Lin, Meng-Liang Chung, Tzu-Min Lin
  • Patent number: 10687714
    Abstract: To perform measurement of a vascular elasticity rate with high accuracy in a short time. A vascular elasticity rate evaluation apparatus of the present invention includes: a pressure detection unit that detects a pulse wave with an external pressure being applied to a blood vessel; and a control unit that forms a pulse wave amplitude indicating dependent characteristics due to elasticity of the blood vessel from a detection value of the pressure detection unit, calculates a plus area in an elevation process of the pulse wave amplitude and a minus area in a descent process thereof, and calculates the vascular elasticity rate using values thereof.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: June 23, 2020
    Assignee: SANYOSEIKO CO., LTD.
    Inventors: Hideaki Shimazu, Futoshi Shirakawa, Yasuyuki Yaguchi
  • Patent number: 10674937
    Abstract: An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: June 9, 2020
    Assignee: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, Jr., Hui Jiang
  • Patent number: 10667698
    Abstract: Methods for diagnosing and/or treating a multi-lesion intravascular region are disclosed. The methods may include advancing a pressure sensing device to a first position that is distal of a first lesion and that is distal of a second lesion, proximally retracting the pressure sensing device to a second position that is proximal of the first lesion and that is proximal of the second lesion, calculating a first estimated post-treatment fractional flow reserve based on treatment of the first lesion, calculating a second estimated post-treatment fractional flow reserve based on treatment of the second lesion, and treating the first lesion, the second lesion, or both based on the first estimated post-treatment fractional flow reserve and the second estimated post-treatment fractional flow reserve.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: June 2, 2020
    Inventor: Masayoshi Yoshida
  • Patent number: 10653364
    Abstract: The invention relates to the field of cardiovascular resuscitation and, more specifically, it concerns a novel method of monitoring the ventriculo-aortic coupling of at-risk patients on the basis of the aortic pressure/flow loop of the patient and the zoning of this loop.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: May 19, 2020
    Assignees: Assistance Publique—Hopitaux de Paris, Universite Paris Diderot—Paris 7
    Inventors: Fabrice Vallee, Alexandre Mebazza, Etienne Gayat, Arthur Le Gall, Jona Joachim
  • Patent number: 10646118
    Abstract: Apparatus and methods for determining a type of a material in a region within a vascular system of a patient and/or a distance to the material are provided. At least one source fiber is provided that supplies light from a light source to a region within a vascular system of a patient. At least one return fiber is provided to receive light reflected from the region within the vascular system. At least one controller is provided to determine at least one property of the region within the vascular system from the reflected light, and to determine a type of a material in the region within the vascular system and/or an indication of a distance to the material. Techniques such as laser ablation may then be performed based on the determined material type and/or distance to remove unwanted buildup, deposits, etc., while avoiding harmful results such as tearing of tissue.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: May 12, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Timothy M. Kowalewski, Darrin D. Beekman, Jack B. Stubbs, Paul Anthony Iaizzo, Gregory K. Peterson
  • Patent number: 10639424
    Abstract: Provided is a drive unit for an auto-injector having a drive unit housing arranged for docking receipt of a syringe or of a cassette unit comprising a syringe movable from a rest position, in which a needle tip of the syringe is within the drive unit housing to a use position, in which the needle tip protrudes from a needle delivery aperture; and a drive arrangement including one or more electrically powered sources of axial drive; a first drive transfer element for advancing the syringe to said use position; and a second drive transfer element for moving a plunger into the barrel of the syringe to eject liquid contents thereof. The drive unit housing is provided with a skin sensor arrangement having an array of plural skin sensor electrodes located about the needle delivery aperture.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: May 5, 2020
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Martin John Mcloughlin, Michael James David Heald, Cameron Townley Charles, Dylan Sanders Garrett, Kevin Richard Lozeau
  • Patent number: 10638982
    Abstract: Systems and methods for non-invasive blood pressure measurement are disclosed. In some embodiments, a system comprises a wearable member configured to generate first and second signals (e.g., PPG signals), and a blood pressure calculation system. The blood pressure calculation system includes a wave selection module configured to identify subsets of waves of the signals, a feature extraction module configured to generate sets of feature vectors form the subsets of waves, and a blood pressure processing module configured to calculate an arterial blood pressure value based on the sets of feature vectors and an empirical blood pressure calculation model, the empirical blood pressure calculation model configured to receive the sets of feature vectors as input values. The blood pressure calculation system further includes a communication module configured to provide a message including or being based on the arterial blood pressure value.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: May 5, 2020
    Assignee: Spry Health, Inc.
    Inventors: Elad Ferber, Ramkrishnan Narayanan, Derya Gol Gungor
  • Patent number: 10638961
    Abstract: A non-invasive, optical-based physiological monitoring system is disclosed. One embodiment includes an emitter configured to emit light. A diffuser is configured to receive and spread the emitted light, and to emit the spread light at a tissue measurement site. The system further includes a concentrator configured to receive the spread light after it has been attenuated by or reflected from the tissue measurement site. The concentrator is also configured to collect and concentrate the received light and to emit the concentrated light to a detector. The detector is configured to detect the concentrated light and to transmit a signal representative of the detected light. A processor is configured to receive the transmitted signal and to determine a physiological parameter, such as, for example, arterial oxygen saturation, in the tissue measurement site.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: May 5, 2020
    Assignee: Masimo Corporation
    Inventor: Ammar Al-Ali
  • Patent number: 10610166
    Abstract: Embodiments of the disclosure are directed to methods, apparatuses, and computer program products for determining a hemodynamic parameter. An exemplary method comprises: receiving data associated with at least one heart beat; calculating a first standard deviation for at least a portion of the data; interpolating a second standard deviation for at least a second portion of the data; and determining the hemodynamic parameter based on the first standard deviation and the second standard deviation.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: April 7, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Zhongping Jian, Jacobus J. G. M. Settels, Feras Al Hatib
  • Patent number: 10613742
    Abstract: A wearable device and a method of providing user interaction with the wearable device is provided. The method includes receiving one or more signals from at least one of one or more pressure sensors and one or more vibration sensors, obtaining information related to at least one of an orientation of the wearable device on a user hand and a hand on which the wearable device being worn based on the one or more signals received, and performing one or more functions based on the obtained information.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: April 7, 2020
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Samudrala Nagaraju, Surjeet Govinda Dash
  • Patent number: 10605684
    Abstract: A transducer modulus, comprising: a supporting substrate; a cap, which is arranged on the supporting substrate and defines a chamber therewith; a pressure transducer in the chamber; an acoustic transducer in the chamber; and a processing chip, or ASIC, operatively coupled to the pressure transducer and to the acoustic transducer. The pressure transducer and the acoustic transducer are arranged on top of one another to form a stack.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: March 31, 2020
    Assignee: STMICROELECTRONICS S.R.L.
    Inventors: Alex Gritti, Marco Omar Ghidoni
  • Patent number: 10595766
    Abstract: In an embodiment, a seizure monitor provides intelligent epilepsy seizure detection, monitoring, and alerting for epilepsy patients or people with seizures. In an embodiment, the seizure monitor may be a wearable, non-intrusive, passive monitoring device that does not require any insertion or ingestion into the human body. In an embodiment, the seizure monitor may include several output options for outputting the accelerometer/gyro or other motion sensor data and video data, so that the data may be immediately validated and/or remotely viewed. The device alerts are communicated to the outside care givers via wireless or wired medium. The device may also support recording of accelerometer or other motion sensor data and video data, which can be reviewed later for further analysis and/or diagnosis. The device and invention is also used and applicable for other body motion disorders or detection and diagnostics.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: March 24, 2020
    Assignee: Smart Monitor Corp.
    Inventors: Anoo Nathan, Vaidhi Nathan
  • Patent number: 10588521
    Abstract: The present invention provides a sphygmomanometer system, including a measurement device pressed against a predetermined part to be measured so that the part to be measured is held down, and a blood pressure measurement device to measure blood pressure based on information from the measurement device. The measurement device includes an average blood pressure detection unit to obtain information on pressure applied to the measurement device, and a blood pressure change amount detection unit to detect a minute change of the part to be measured when the blood pressure change amount detection unit contacts with the part to be measured. The processor of the blood pressure measurement device calculates the average blood pressure, the highest blood pressure, and the lowest blood pressure based on information on pressure obtained from the blood pressure change amount detection unit and the average blood pressure detection unit.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: March 17, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Akihiko Kandori, Yuko Sano, Toshio Tsuji, Harutoyo Hirano
  • Patent number: 10575780
    Abstract: An apparatus comprises a sensor for measuring a physiological parameter of a subject, wherein the physiological parameter sensor is adapted to be worn by the subject; an actuator comprising an electro-active polymer material, EAP, portion for adjusting the position of the physiological parameter sensor relative to the subject; a feedback sensor for measuring movement of the physiological parameter sensor and/or the subject; a controller configured to process the measurements of the feedback sensor and to adjust the position of the actuator based on information from the feedback sensor.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 3, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Daan Anton van den Ende, Reinder Haakma, Mark Thomas Johnson, Frederick Maria Boekhorst, Milica Kovacevic Milivojevic, Franciscus Johannes Gerardus Hakkens, Achim Hilgers, Cornelis Petrus Hendriks, Rene Leonardus Jacobus Marie Ubachs, Eduard Gerard Marie Pelssers
  • Patent number: 10579824
    Abstract: A facility for accessing information relating to a person is described. In a reader device, the facility accesses first credentials stored in a first storage device, second credentials stored in a second storage device, and third credentials stored in the reader device. In the reader device, the facility uses a combination of the first credentials, second credentials, and third credentials to decrypt information relating to the person stored in the first storage device.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: March 3, 2020
    Assignee: VYRTY CORPORATION
    Inventors: Raif Khassonov, Eugene Luskin, Yakov P. Grinberg, Eugene Kolker
  • Patent number: 10569006
    Abstract: The invention relates to a device A for monitoring a vessel opening for an extracorporeal blood treatment device B with an extracorporeal blood circulation (I), which has an arterial blood line (20) with an arterial cannula (19) and a venous blood line (21) with a venous cannula (22). Moreover, the invention relates to an arrangement with a device A for monitoring a vessel opening and an extracorporeal blood treatment device B, and a method for monitoring a vessel opening during an extracorporeal blood treatment. The monitoring device A comprises a sensor (1) for detecting at least one physical variable, which is characteristic for the state of the vessel opening, and an evaluation apparatus (7), connected to the sensor (1) by way of a connection cable (6), for producing signals characteristic for the state of the vessel opening. The evaluation apparatus (7) has a data transmission unit (38) for establishing a wireless connection between the evaluation apparatus (7) and the blood treatment device B.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: February 25, 2020
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Thomas Stahl
  • Patent number: 10561363
    Abstract: The medication alert watch is a medical instrument that is adapted for use with a person. The medication alert watch is adapted to be worn on a wrist of the person. The medication alert watch comprises a control system, a cuff mechanism, a heart sensor, a power system, a housing, and a band. The control system monitors and operates the cuff mechanism. The control system monitors the heart sensor. The power system provides electrical power to the control system, the cuff mechanism, and the heart sensor. The control system, the cuff mechanism, the heart sensor, and the power system are located in the housing. The band attaches the wrist to the housing. The medication alert watch: 1) maintains and monitors a plurality of appointments and generates notifications regarding the appointment; 2) monitors the medical status of the person; and, 3) generates notifications regarding the medical status of the person.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: February 18, 2020
    Inventors: Islande Florissant, Edny Florissant
  • Patent number: 10555676
    Abstract: The invention provides a body-worn monitor that measures a patient's vital signs (e.g. blood pressure, SpO2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g. resting, walking, convulsing, falling). The body-worn monitor processes this information to minimize corruption of the vital signs by motion-related artifacts. A software framework generates alarms/alerts based on threshold values that are either preset or determined in real time. The framework additionally includes a series of ‘heuristic’ rules that take the patient's activity state and motion into account, and process the vital signs accordingly. These rules, for example, indicate that a walking patient is likely breathing and has a regular heart rate, even if their motion-corrupted vital signs suggest otherwise.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: February 11, 2020
    Assignee: SOTERA WIRELESS, INC.
    Inventors: Devin McCombie, Marshal Dhillon, Matt Banet
  • Patent number: 10548531
    Abstract: The present invention relates to a foldable case-integrated multi-device and a health management system using the same, in which health management and life management functions are implemented by introducing various sensors into a foldable case for a communication device. According to the present invention, a sensor module configured to measure biometric information is contained in a foldable case, and power supply, data processing and analysis, and display are implemented using internal components of the communication device, thereby providing a cutting-edge health care function while maintaining a communication device in a light, thin, short and small form.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: February 4, 2020
    Assignee: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
    Inventors: Kyung Eun Park, Jong Jin Park
  • Patent number: 10542961
    Abstract: Cardiac Output (CO) has traditionally been difficult, dangerous, and expensive to obtain. Surrogate measures such as pulse rate and blood pressure have therefore been used to permit an estimate of CO. MEMS technology, evolutionary computation, and time-frequency signal analysis techniques provide a technology to non-invasively estimate CO, based on precordial (chest wall) motions. The technology detects a ventricular contraction time point, and stroke volume, from chest wall motion measurements. As CO is the product of heart rate and stroke volume, these algorithms permit continuous, beat to beat CO assessment. Nontraditional Wavelet analysis can be used to extract features from chest acceleration. A learning tool is preferable to define the packets which best correlate to contraction time and stroke volume.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: January 28, 2020
    Assignee: The Research Foundation for the State University of New York
    Inventors: Ohad Barsimantov, Kenneth McLeod, J. David Schaffer
  • Patent number: 10542893
    Abstract: A monitoring apparatus includes a housing that is configured to be attached to a body of a subject. The housing includes a sensor region that is configured to contact a selected area of the body of the subject when the housing is attached to the body of the subject. The sensor region is contoured to matingly engage the selected body area. The apparatus includes at least one physiological sensor that is associated with the sensor region and that detects and/or measures physiological information from the subject and/or at least one environmental sensor associated with the sensor region that is configured to detect and/or measure environmental information. The sensor region contour stabilizes the physiological and/or environmental sensor(s) relative to the selected body area such that subject motion does not impact detection and/or measurement efforts of the sensor(s).
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: January 28, 2020
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
  • Patent number: 10541436
    Abstract: A fuel cell purging method is provided to effectively prevent fuel cell deterioration and degradation of durability of the fuel cell by performing hydrogen purging at a point in time at which negative pressure of an anode peaks after a fuel cell vehicle is stopped. The fuel cell purging method includes stopping the driving of a fuel cell vehicle and continuously measuring pressure of an anode of a fuel cell after the fuel cell vehicle is stopped. Additionally, hydrogen is supplied to the anode when the measured pressure of the anode reaches a negative pressure peak time point.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: January 21, 2020
    Assignee: Hyundai Motor Company
    Inventors: Hyun Jae Lee, Jong Hyun Lee, Deuk Kuen Ahn, Yei Sik Jeon
  • Patent number: 10531802
    Abstract: A system for vital sign measuring of a patient, comprising: a first sensor removably attachable with a first body portion of the patient and configured to measure, when in operable position, a vital sign of the patient; at least one additional sensor removably attachable with a second body portion of the patient and configured to measure, when in operable position, a vital sign of the patient; and a processor configured to provide data descriptive of a level of correspondence between measurements of the vital signs provided by the first sensor and the at least one additional sensor.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: January 14, 2020
    Assignee: MOR RESEARCH APPLICATIONS LTD.
    Inventors: Nimrod Adi, Gil Zoizner, Jonathan Rubin
  • Patent number: 10531797
    Abstract: An apparatus includes one or more memories storing computer readable code and processor(s). The processor(s), in response to loading and executing the computer readable code, cause the apparatus to perform operations including receiving electrocardiogram data from an electrocardiogram sensor. The electrocardiogram data includes data from an electrocardiogram from a person. The operations also include receiving pulse wave data from one or more pulse wave pressure sensors. The pulse wave data includes data from one or more pulse waves from the person. The operations further include determining blood pressure using the electrocardiogram data or the pulse wave data from the chest and the pulse wave data from the wrist or finger, and outputting an indication of the blood pressure. Another apparatus uses pulse wave data from two pulse wave sensors (e.g., pulse wave pressure sensor(s) and/or PPG sensor(s)) and blood pressure determinations are made using these pulse wave data.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: January 14, 2020
    Assignee: International Business Machines Corporation
    Inventors: John U. Knickerbocker, Hyung-Min Lee, Kang-Wook Lee
  • Patent number: 10524672
    Abstract: Various embodiments include methods and devices for measuring blood pressure. Various embodiments may include receiving, from one or more arterial measurement sensors, a pulse waveform representing arterial pressure as a function of time for each pulse of a series of blood pressure pulses. The series of blood pressure pulses may be correlated to arterial distension at a measurement location of the arterial measurement sensors on a subject's body. One or more elevations of the measurement location may be received from one or more elevation sensors. At least one pulse in the series of pulses may be identified that represents a transitional pulse based on one or more characteristics of the at least one pulse. A diastolic blood pressure may be determined based on the at least one identified transitional pulse and elevation measurements that correspond to the one identified pulse.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: January 7, 2020
    Assignee: CAPSULE TECHNOLOGIES, INC.
    Inventors: David Boettcher Baek, Lars Lading
  • Patent number: 10528029
    Abstract: An electrocardiograph (ECG) simulator is provided to generate sequences of wave shapes having specified average rates for a sequence of varying rates.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: January 7, 2020
    Inventor: Harold T. Fogg