Abstract: In accordance with one aspect of the present technique, a method is disclosed. The method includes applying a mechanical perturbation to a tissue region using a displacement device. The method further includes calculating a compression impedance of the tissue region in response to applying the mechanical perturbation. The method further includes retracting the displacement device and calculating a retraction impedance of the tissue region in response to retracting the displacement device. The method also includes determining a hydration level of the tissue region based on at least one of the compression impedance and the retraction impedances.

Abstract: The invention disclosed herein provides methods for implementing Sampling Interval Modulation Magnetic Resonance Elastography (“SLIM-MRE”), based on simultaneous encoding and acquisition of individual displacement components using motion encoding gradients with different time discretization intervals to MRI analysis. The components are modulated with different frequencies in the MR signal phase, which can be expressed as a harmonic function of the start time, or equivalently of initial phase, of the motion encoding gradient components. As a result, all displacement components can be acquired faster than in conventional MRE, and can be derived from the same temporally-resolved MR phase images. This also allows for simultaneously acquired 3D displacement data and storage of such data in the same k-space.

Abstract: A medical instrument is disclosed for crushing a thrombus present in a pulmonary artery of a living body by an ultrasonic vibration. The medical instrument includes an elongated main body section capable of being inserted into an airway of the living body, and an ultrasonic oscillation section which can be inserted into the living body by the main body section and which oscillates the ultrasonic vibration inside the living body. By the medical instrument, a thrombus present in a pulmonary artery can be rapidly crushed, whereby a therapeutic effect on pulmonary embolism can be obtained.

Abstract: A device and method for use in monitoring blood pressure. The device comprises a controller configured to monitor a first blood pressure measurement based on a first blood pressure signal. The controller is configured to initiate acquiring a second blood pressure measurement based on a second blood pressure signal if the first blood pressure measurement exceeds a predetermined threshold. The decision to initiate acquiring the second blood pressure measurement is based on only one blood pressure measurement.

Abstract: Devices, systems, and methods for the localization of body lumen junctions and other intraluminal structure are disclosed. Various embodiments permit clinicians to identify the locations of intraluminal structures and medical devices during non-surgical medical techniques, such as cardiac ablation, by determining the intralumen conductance and/or cross-sectional area at a plurality of locations within the body lumen.

Abstract: A mobile terminal according to the present invention includes a terminal main body, a user input unit provided at the terminal main body and capable of receiving a control command for executing a specific function, a sensor unit provided adjacent to the user input unit and capable of sensing biometric information during the reception of the control command, and a controller capable of executing the specific function based on the control command and calculating a blood pressure value using the biometric information.

Abstract: Disclosed is a PPG signal measurement apparatus comprising a light source for emitting light pulses; a light sensor for receiving reflected light from the light source and generating a sensor signal; an electronic unit including a transimpedance amplifier and an ambient light cancelation unit, a first switch in a front end portion of the light sensor, a second switch in the front end portion of the light sensor, a microcontroller in communication with the light source, the light sensor, and the ambient light cancellation unit.

Abstract: A method for determining an artery location on a living subject's skin and positioning a tonometry pressure sensor on the artery location for tonometric blood pressure measurement is provided. The method comprises a non-contact optical search followed by a contact pressure search. In the non-contact optical search, an optical-sensing unit is used to scan the skin along a scan path while maintaining a pre-determined distance between the unit and the scan path. A search region within the scan path and a height profile characterizing the scan path's curvature are determined. The search region is determined such that an artery is predicted to lie thereunder. The artery location is then searched within the search region by the contact pressure search, in which the pressure sensor sweeps along the search region and the sweeping is guided by curvature information provided by the height profile. A device using the method is also provided.

Abstract: A system or a method for measuring flow of fluid or gas, has a flow duct with at least two transducers which generate at least one beam of ultrasound in the flow duct in which ultrasound transducers are placed in a fixed positions in a duct for flowing air where the electronic device for analyzing signal from the transducers is performed in a handheld device. A transmitter circuit is permanently connected to the transducers and a receiver circuit is placed in a handheld device. The transmitter circuit has calibration data representing the actual placement of the transducers in relation to the actual duct, which calibration data is communicated by every connection to the receiver circuit. Hereby can be achieved that transducers can be permanently placed in ventilation ducts in buildings, where placement of ultrasound transducers for measurement and for calibration of measurement of an air stream is nearly impossible.

Abstract: The invention provides a body-worn monitor that measures a patient's vital signs (e.g. blood pressure, SpO2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g. resting, walking, convulsing, falling). The body-worn monitor processes this information to minimize corruption of the vital signs by motion-related artifacts. A software framework generates alarms/alerts based on threshold values that are either preset or determined in real time. The framework additionally includes a series of ‘heuristic’ rules that take the patient's activity state and motion into account, and process the vital signs accordingly. These rules, for example, indicate that a walking patient is likely breathing and has a regular heart rate, even if their motion-corrupted vital signs suggest otherwise.

Abstract: A physiological monitoring system features a Floormat and Handheld Sensor connected by a cable. A user stands on the Floormat and grips the Handheld Sensor. These components measure time-dependent physiological waveforms from a user over a conduction pathway extending from the user's hand or wrist to their feet. The Handheld Sensor and Floormat use a combination of electrodes that inject current into the user's body and collect bioelectric signals that, with processing, yield ECG, impedance, and bioreactance waveforms. Simultaneously, the Handheld Sensor measures photoplethysmogram waveforms with red and infrared radiation and pressure waveforms from the user's fingers and wrist, while the Floormat measures signals from load cells to determine ‘force’ waveforms to determine the user's weight, and ballistocardiogram waveforms to determine parameters related to cardiac contractility.

Abstract: A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity. A third sensor configured to monitor pulsations of a distal artery. A processing system responsive to signals from the first, second, and third sensors is configured to determine intracranial pressure.

Abstract: An airbag for a blood pressure measuring device for fixing a cuff, including: a main sheet member which spreads in two layers forming a bag body, wherein a constricted portion is formed on the bag body, the constricted portion narrowing the air chamber with respect to the width direction, a pair of sub sheet members are disposed so as to correspond to the respective layers of the main sheet member, the sub sheet member occupying a region including at least a portion corresponding to the constricted portion, and the pair are respectively welded to the layers of the main sheet member at the constricted portion, the pair being welded to the corresponding layers of the main sheet member at a center near portion away from the constricted portion toward a center side with respect to the width direction.

Abstract: A method and device for detecting a blood flow rate are disclosed. The method comprises steps: providing a detection light source, and projecting a light of the detection light source onto a skin of a living body and reach a blood vessel; using a photo sensor to receive a plurality of polarized light beams which are formed by the light of the detection light source reflected by expanding or contracting the blood vessel, wherein the photo sensor respectively generates a first PPG signal and a second PPG signal in blood vessel expansion and contraction; using a microprocessor to acquire at least one first PPG signal and at least one second PPG signal, calculating an offset of received light beams and a time derivative thereof according to a sequence of the first PPG signal and the second PPG signal, and converting the offset and time derivative into a blood flow rate.

Abstract: Various embodiments relating to a method of controlling the blood pressure of a subject is provided, the method includes generating blood pressure data indicating the blood pressure of the subject, controlling a plurality of pumps to infuse, in dependence on the blood pressure data, drugs into the subject, wherein each of the plurality of pumps is adapted to infuse one out of a plurality of different drugs into the subject, and wherein each of the plurality of different drugs has a particular influence on the blood pressure of the subject, wherein the plurality of pumps is controlled such that, in dependence on the blood pressure data, a mix of drugs is infused into the subject which stabilizes the blood pressure of the subject.

Abstract: An apparatus determining an exercise capability of an individual by obtaining heart rate information of the individual, detecting a characteristic point from the heart rate information, and obtaining information to be used to determine the exercise capability of the individual based on the characteristic point.

Abstract: A medical system, comprising an ablation catheter is disclosed. The ablation catheter includes an elongate shaft with a proximal end, a distal end and a lumen disposed between the proximal end and the distal end. The ablation catheter also includes an expandable element in fluid communication with the lumen, a first temperature sensor operable to measure a first temperature; and a second temperature sensor operable to measure a second temperature. The first temperature sensor and the second temperature sensor are longitudinally separated from each other by at least a portion of the expandable element.

Abstract: Disclosed herein is a wireless implantable communication system, method and sensing device, wherein an implantable data conversion module is adapted for operative coupling to a distinct or integrated implantable sensing device for the conversion of a characteristic signal for transmission thereof to an external receiver, e.g. by way of an inductive element. Upon positioning an external inductive element in the vicinity of the implanted device, a corresponding signal is induced within the external element allowing for reconstruction of the converted signal, and thereby allowing for recovery of the characteristic signal. Embodiments for the communication of data across a biological barrier, including communications from an external transmitter to an implanted receiver, an implanted transmitter to an external receiver, and an implanted transmitter/receiver pair are also disclosed.

Abstract: Average blood pressure data of a morning time zone of every week and average blood pressure data of a night time zone of every week calculated by an average calculation portion are stored in a memory by performing blood pressure measurement. An every-week processing portion alternately switches and displays the average blood pressure data of the morning time zone and the average blood pressure data of the night time zone read from the memory based on an instruction input through an operation unit on a display unit every three seconds, or the like.

Abstract: The invention relates to an intercardiac pump device comprising a pump (11) whose distal end (13) is connected to a cannula (15) which is provided with a suction head (16) for sucking blood. Said strainer is provided with a non-sucking extension (20) for stabilizing the position of said pump device in the heart and mechanically prolonging the cannula (15) without deteriorating hydraulic conditions. Said extension is also used in the form of a spacer in order to avoid that the suction head (16) adheres to a cardiac wall.

Abstract: In accordance with embodiments of the present disclosure, a user-platform apparatus, such as a bodyweight sensing scale, includes a heart/cardiogram sensor which is used to detect heart and vascular characteristics of a user, and provide a cardiogram output indicative of the detected cardiovascular characteristics. The cardiogram output can be used for various purposes, such as detecting arterial stiffness and/or aging.

Abstract: A sensor guide wire device (200) for intravascular measurements of a physiological variable in a living body is disclosed. The sensor guide wire (200) may comprise a sensor element (213) and a connector unit (220). The connector unit (220) is attachable to a signal converting device (310). The sensor element (213) provides the signal converting device (310) with a signal indicative of a physiological variable sensed by the sensor element (213). Furthermore, the connector unit (220) comprises a battery (222). A system (300) comprising the sensor guide wire device (200) and the signal converting device (310) is also disclosed.

Abstract: Provided are embodiments of a computer mouse for sensing health characteristics of a user. The computer mouse including a location sensor adapted to sense movement of the computer mouse, a temperature sensor adapted to sense a body temperature of the user, a blood condition sensor adapted to sense a blood saturation level of the user, and a blood pressure sensor adapted to sense a blood pressure of the user. The computer mouse including a controller to transmit, to a computer workstation, location data corresponding to the sensed movement of the computer mouse, temperature data corresponding to the sensed body temperature, blood condition data corresponding to the sensed blood saturation level, and blood pressure data corresponding to the sensed blood pressure, for determining movement of the mouse and body temperature, blood saturation level, and the blood pressure of the user.

Abstract: A method, system, and computer-readable medium for fall detection of a user are disclosed. In a first aspect, the method comprises determining whether first or second magnitude thresholds are satisfied. If the first or second magnitude thresholds are satisfied, the method includes determining whether an acceleration vector of the user is at a predetermined angle to a calibration vector. In a second aspect, the system comprises a processing system and an application that is executed by the processing system. The application determines whether first or second magnitude thresholds are satisfied. If the first or second magnitude thresholds are satisfied, the application determines whether an acceleration vector of the user is at a predetermined angle to a calibration vector.

Abstract: An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.

Abstract: A wearable terminal can include a main body configured to be in contact with a body of a user using one side of the main body, a photo plethysmography including a transmitter combined with one side of the main body and outputs a output signal, and a receiver detecting a reflection signal corresponding to the output signal returned, a cover configured to cover the photo plethysmography and be combined with the main body and a controller configured to measure a heart rate based on a reflection signal measured by the photo plethysmography. The cover is combined with the main body and parts corresponding to the transmitter and the receiver of the photo plethysmography include transparent units through which the output signal and the reflection signal are passing and a barrier unit positioned between the transparent units and shielding the output signal and the reflection signal.

Abstract: A device for measuring brachial arterial blood pressure in an individual has a blood pressure cuff attachable to an upper arm, means, separate to the blood pressure cuff, for measuring the heart rate, and a control unit connected to both the blood pressure cuff and the heart rate monitoring means, such that, in use, the control unit monitors the heart rate for the establishment of a stable resting heart rate, initiates a blood pressure measurement, and calculates the pulse pressure (PP) to establish the status of the brachial artery during the blood pressure measurement. Where the heart rate drops to within +12 bpm of a reference, resting heart rate for the individual the device will initiate a blood pressure measurement in accordance with a reference, resting heart rate protocol. However, where an irregular heart rate (IRHR) is found the device will initiate a blood pressure measurement in accordance with a timed protocol.

Abstract: The method of positioning a Doppler ultrasound transducer for performing blood flow measurement according to the invention comprises the steps of: detecting a pressure oscillation signal from an inflated cuff placed on patient's artery; detecting an ultrasound pulse signal from the Doppler ultrasound transducer placed along the artery; deriving a first signal from the pressure oscillation signal and the ultrasound pulse signal, the first signal indicating the degree of synchronization between the pressure oscillation signal and the ultrasound pulse signal; and outputting an indication signal to indicate the Doppler ultrasound transducer is in a desired position when the first signal satisfies a predefined condition.

Abstract: A photoelectric sensor retainer and a photoelectric pulse wave measuring apparatus including the same are provided. The photoelectric sensor retainer includes a sensor mounting unit on which a photoelectric sensor having a light-receiving surface is attachable and detachable, the light-receiving surface facing a measuring direction. The photoelectric sensor retainer further includes a pressing unit configured to press an upper surface of the sensor mounting unit in the measuring direction to apply pressure to the sensor mounting unit, and a pedestal including a seating plate configured to support the pressing unit, the seating plate having a principal plane perpendicular to a pressing direction of the pressing unit.

Abstract: The present invention relates to a ring-type cuff for blood pressure manometer, wherein the cuff (C) comprises: a circular rubber ring (1) wearable on a wrist or an ankle; a resilient coil spring (2) built-in inside the tubular rubber ring (1) in the range of length of the rubber ring to obtain a predetermined flexibility, to suppress excessive stretching, to strengthen durability, and to maintain resilience; and a measurement portion (3) comprising a pressure sensor (S) for measuring blood pressure, a transmission circuit (IC) for transmitting measurement data to the outside, a power source (v), a power switch (sw), and a pilot lamp (LED).

Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.

Abstract: An implantable system includes terminals, a pulse generator, a sensing circuit, separate signal processing channels, and first, second and third multiplexers. The terminals are connected to electrodes via conductors of leads. Different subsets of the electrodes are used to define different electrical pulse delivery vectors, and different subsets of the electrodes are used to define different sensing vectors. The pulse generator produces electrical pulses, and the sensing circuit senses a signal indicative of an impedance associated with a selected sensing vector. The first multiplexer selectively connects outputs of the pulse generator to a selected one of the different electrical pulse delivery vectors at a time. The second multiplexer selectively connect inputs of the sensing circuit to a selected one of the different sensing vectors at a time. The third multiplexer selectively connects an output of the sensing circuit to one of the plurality of separate signal processing channels at a time.

Abstract: An implantable device for harvesting in-vivo blood pressure fluctuations' energy to generate electrical power for powering medical implants while avoiding the need for external power sources.

Abstract: A biosignal measuring device has a first information acquisition module, a second information acquisition module, a first calculation module, a second calculation module, a third calculation module, a heartbeat interval estimation module, a determination module, and an output module. The first information acquisition module acquires the pulse wave signal. The second information acquisition module acquires an electrocardiogram signal. The first calculation module calculates a pulse wave velocity based. The second calculation module determines a heartbeat interval. The third calculation module calculates a relationship between pulse wave velocity and the heartbeat interval. The heartbeat interval estimation module estimates an estimated heartbeat interval based on pulse wave velocity and calculated relationship. The determination module determines whether the position of the first and second information acquisition modules has changed based on the heartbeat interval and the estimated heartbeat interval.

Abstract: A biological information displaying apparatus includes: a calculator which is configured to calculate measurement values of parameters based on a plurality of biological signals obtained by an acquiring unit, the parameters including: sclerosis parameters relating to arterial sclerosis; and stenosis and/or occlusion parameters relating to arterial stenosis and/or occlusion; a display which is configured to display information; and a display controller which is configured to produce different radar charts of the sclerosis parameters and the stenosis and/or occlusion parameters, and which is configured to display the measurement values of the parameters on the display, on respective one of line segments that radially extend from a center in each of the radar charts, while plotting each of the measurement values of corresponding parameters at a position that is remoter from the center as a clinical value is worse.

Abstract: A patient monitoring system may generate a derivative signal from a physiological signal. The derivative signal may be filtered based on a pulse rate estimate associated with the physiological signal. A plurality of crossing points may be determined for the filtered derivative signal and translated to the derivative signal. A plurality of fiducial points may be determined for the derivative signal based on the plurality of crossing points. The plurality of fiducial points may be utilized to determine physiological information from the physiological signal.

Abstract: Improved apparatus and methods for non-invasively assessing one or more physiologic (e.g., hemodynamic) parameters associated with a living organism. In one embodiment, the invention comprises an apparatus adapted to automatically and accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject. The apparatus is comprised of a sensor device removably coupled to a host device which is used to position the sensor during measurements. Methods for positioning the alignment apparatus and sensor, and operating the apparatus, are also disclosed.

Abstract: A method, medium, and apparatus for measuring a heart rate from blood flow in a blood vessel of a human body part, including: an amplifying circuit receiving a light signal reflected or penetrated from a human body part and generating a multi-stage amplified signal made up of a plurality of signals with a corresponding different gains; and a processor separating the multi-stage amplified signal into a plurality of channel signals having corresponding gains, reconfiguring the light signal using a channel signal selected among the plurality of channel signals and calculating the heart rate from the reconfigured light signal. Accordingly, it is possible to make an accurate measurement of a heart rate by minimizing effects of measuring environments. In addition, the apparatus, method, and medium are resistive to noise resulting from a movement of a human body part by comparing an optimum signal pattern and a correlation coefficient.

Abstract: A probabilistic digital signal processor is described. Initial probability distribution functions are input to a dynamic state-space model, which operates on state and/or model probability distribution functions to generate a prior probability distribution function, which is input to a probabilistic updater. The probabilistic updater integrates sensor data with the prior to generate a posterior probability distribution function passed (1) to a probabilistic sampler, which estimates one or more parameters using the posterior, which is output or re-sampled in an iterative algorithm or (2) iteratively to the dynamic state-space model. For example, the probabilistic processor operates using a physical model on data from a mechanical system or a medical meter or instrument, such as an electrocardiogram. Output of the physical model yields an enhanced output of the original data, an output to a second physical parameter not output by the medical meter, or a prediction, such as an arrhythmia warning.

Abstract: A blood pressure measurement device measures blood pressure and a blood pressure change affecting factor of a patient. The device includes a memory, a tolerance determination section, and a display unit. The tolerance determination section includes a rest/unrest condition determination section and a blood pressure tolerance determination section. The tolerance determination section determines whether the blood pressure of the patient is tolerant to the blood pressure change affecting factor. The display unit of the device displays the measured blood pressure, the measured blood pressure change affecting factor, and a tolerance determination of the patient.

Abstract: A portable, cuffless instrument and system for providing rapid measurements of vital signs of a patient undergoing trauma from illness or injury comprising a portable instrument connectable via contact sensors to the patient to produce a vital sign data set including blood pressure, pulse, blood oxygen saturation, and body temperature. The instrument preferably includes wireless communication capability in a network and system including a remote server, database, and processing capability to provide access to electronic medical records, to analyze the vital signs data, report preliminary diagnoses to a care giver, including listing chronologically vital sign data for trends.

Abstract: A central arterial blood pressure waveform is developed from pressure waveforms obtained from proximal and distal blood pressure cuffs on the brachial artery of an arm that are inflated to a supra-systolic pressure. The proximal and distal cuff pressure waveforms associated with at least one cardiac ejection cycle are sensed. The propagation times of a blood pressure pulse from the entry of the artery to the proximal cuff and from the proximal cuff to the distal cuff are calculated, permitting calculation of a reflection coefficient of the pressure pulse at one of the proximal and distal cuffs. Assuming a physical model of wave propagation along the artery between the aorta and the proximal and distal cuffs, an estimated pressure waveform at the opening of the artery can be determined.

Abstract: A device and method for use in monitoring blood pressure. The device comprises a controller configured to monitor a first blood pressure measurement based on a first blood pressure signal. The controller is configured to initiate acquiring a second blood pressure measurement based on a second blood pressure signal if the first blood pressure measurement exceeds a predetermined threshold. The decision to initiate acquiring the second blood pressure measurement is based on only one blood pressure measurement.

Abstract: Devices and methods for providing feedback on breathing rate are disclosed. The device comprises: a sensor interface configured to receive an electrocardiogram ECG signal; an ECG analysis unit configured to obtain a breathing rate from the received ECG signal; a feedback output mechanism for providing feedback; and a feedback generator configured to obtain an optimal breathing rate in accordance with a desired outcome and one or more heart rate and/or breathing rate characteristics detected from the ECG signal. The feedback generator is further configured to control the feedback output mechanism to output feedback synchronized to the optimal breathing rate, and subsequently adapt the feedback in accordance with changes in the one or more heart rate and/or breathing rate characteristics while the feedback is being outputted.

Abstract: A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.

Abstract: Described are computer-based methods and apparatuses, including computer program products, for outpatient monitoring. In some examples, the outpatient monitoring technology includes a system for remote monitoring and consultations of patients' state associated with automated interpretation of vital signs signals. In other examples, the outpatient monitoring technology includes a system for remote monitoring of patients' state associated with analysis of full-disclosure vital signs digital signals with reduced bit data or channel data. In some examples, the outpatient monitoring technology includes a system for remote monitoring of patients' state associated with ongoing automated analysis and transmission of full-disclosure vital signs digital signals and automatically generated signals' interpretation results and manually marked patient symptoms.

Abstract: Described is an apparatus which comprises: an amplifier; and a passive continuous-time linear equalizer integrated with a baseline wander (BLW) corrector, wherein the integrated equalizer and BLW corrector is coupled to the amplifier.

Abstract: Provided are systems and methods for noninvasively assessing intracranial pressure by controllably osculating at least a portion of a subject's ocular globe while applying a force sufficient to collapse an intraocular blood vessel and correlating the collapse pressure to intracranial pressure. Also provided are ophthalmic components useful in ophthalmic imaging applications, such as retinal, corneal, and pupil imaging. The components may include an optical contact surface that has a radius of curvature that is greater than the radius of curvature of a subject's cornea.

Abstract: Method for assessing a regurgitant flow through a valve into a moving object from a sequence of consecutive image frames of such object, which images are timely separated by a certain time interval, the method comprising the following steps: a) identifying in the images the object of interest; b) augmenting the images to compensate for protocol intensity variation and/or motion and/or background; c) making a time-analysis of augmented images to obtain time-density curve or curves, wherein time-density curves represent a time-evolution of pixel brightness; d) determining a plurality of parameters related to such time-density curve or curves; e) weighting such parameters to provide indications on the regurgitant flow. A corresponding apparatus and computer program are also disclosed.

Abstract: The systems and methods described herein enable reliable estimation of cardiovascular indices on real-time, non-invasive or minimally-invasive, and beat-to-beat basis. Cardiovascular indices which can be estimated include: stroke volume (SV), which being limited to, cardiac output (CO) and total peripheral resistance (TPR). In various embodiments, one or more of these indices are estimated continuously, on a beat-to-beat basis, using peripheral arterial blood pressure (ABP) waveforms and certain parameters derived from the peripheral ABP waveforms. The derived parameters are substantially insensitive to distortions of the ABP waveform arising from tapered arterial branches throughout the arterial tree. The methods describe herein can provide a more accurate and reliable estimate of hemodynamic parameters than existing techniques.