Abstract: An injection device comprising a housing having a longitudinal axis, a dose selector (16) capable of being rotated about said longitudinal axis with respect to said housing by a user to set a dose of medicament to be ejected from the injection device and a spring (20) capable of storing energy necessary for ejecting the dose of medicament from the injection device. The spring is coupled to the dose selector such that a charging force can be transferred from the dose selector to the spring to increase the energy stored by the spring. The injection device further comprises a ratchet arrangement (25) moveable between an engaged state in which the spring is limited from unwinding from a currently selected dose and a disengaged state in which the spring is able to unwind and a drive assembly including a plunger element (23) capable of providing an axial force for ejecting a dose of medicament from the injection device.

Abstract: A device for filling and priming syringes is provided and comprises a support base, an engagement seat defined on the support base to receive a rear end of a syringe barrel of a syringe provided with a sliding plunger, engaging means defined at the engagement seat to cooperate with the syringe barrel for firmly holding the syringe to the engagement seat, a first vacuum pump or compressor which is provided with a suction opening communicating with the engagement seat to generate an under-pressure in the volume comprised between the plunger and the engagement seat when the syringe is firmly engaged in the engagement seat, and a second vacuum pump or compressor which is provided with a discharge opening communicating with the engagement seat to generate an over-pressure in the volume comprised between the plunger and the engagement seat when the syringe is thinly engaged in the engagement seat.

Abstract: Described is a medicament container carrier adapted to hold a first medicament container having a first predetermined size and capable of containing more than a first volume of a medicament. The container carrier comprises a body, and an adapter coupled to the body. The adapter is adapted to hold a second medicament container having a second predetermined size different from the first predetermined size and capable of containing no more than the first volume of the medicament.

Abstract: A medicament delivery device is presented having a housing configured to accommodate a medicament container filled with medicament, a drive unit comprising a plunger rod operable to act on the medicament container, a mechanical activation mechanism configured to interact with the drive unit, where the mechanical activation mechanism is movable between certain predetermined states when interacting with the drive unit, a recording unit capable of recording status changes of the medicament delivery device including the status of the mechanical activation mechanism, and detection elements operably connected to the recording unit and positioned such as to detect when the activation mechanism has been moved between certain predetermined states.

Abstract: An automatic injection device including an injection syringe equipped with a syringe body and with a piston rod mounted movably in this syringe body so as to cover an injection stroke, a piston control member capable of changing between a configuration in which it is in engagement with the piston rod and a configuration in which it is disengaged from this piston rod, mechanism for moving the piston control member between its two configurations with respect to the piston rod. The mechanism for moving the control member between its two configurations includes a camway carried by a disengagement member and a cam carried by the control member. The disengagement member is movable with respect to the piston rod and the syringe body after the end of the injection stroke, in such a way as to cause the camway to interact with the cam.

Abstract: A syringe assembly for administration of a neurotoxin, the syringe assembly comprising: a syringe comprising: a clear syringe barrel with dosage markings completely encircling the clear syringe barrel; and a plunger having a plunger body and a clear inverted plunger tip; and a needle assembly comprising a needle and a sealing hub for removably attaching the needle assembly to the syringe, wherein the needle is approximately 0.15 inches to approximately 0.3 inches in length and has a gauge of approximately 27 gauge to approximately 35 gauge.

Abstract: A drug delivery device comprising a rotatable scale drum, a trigger member, an actuation member, a trigger spring acting on the trigger member and being energized by movement of the actuation member, as well as an end-of-dose switch adapted to be actuated by movement of the trigger member. The trigger member is adapted to be arranged in an axially supported position against the action of the energized trigger spring, and released from the axially supported position when the scale drum is rotated from a set position to an end-of-dose position, whereby the trigger member is moved axially by the trigger spring, the end-of-dose switch thereby being actuated.

Abstract: The present disclosure is directed to a spring arrangement for use in a drug delivery device and a drug delivery device including such a spring arrangement. The spring arrangement includes a clutch spring which is located axially interposed between a stationary housing component and an axially movable sleeve. The sleeve includes clutch features adapted to engage corresponding clutch features of a clutch element. The clutch spring biases the clutch features and the corresponding clutch features into engagement. The sleeve is coupled to a button such that upon actuation of the button the sleeve is translated against the bias of the clutch spring from a proximal position in which the sleeve is rotationally locked to the housing component into a distal position in which the sleeve is rotationally un-locked from the housing component. Upon release of the button the clutch spring translates the sleeve and the button into the proximal position.

Abstract: A device that regulates, monitors, and provides data on the progress of a large-volume injector during its injection sequence. The device comprises an injector and a monitor assembly. The injector has a syringe having a plunger, and a biasing device that biases the plunger through the syringe. The monitor assembly comprises a resistance unit configured to resist movement of the plunger, a gear connected to the plunger by the resistance unit, and a control unit configured to monitor the position, and regulate the rotation, of the gear. Wherein linear movement of the plunger causes the gear to rotate so that the control unit generates information on the position of the plunger.

Abstract: An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw.

Abstract: A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Abstract: The present disclosure relates to a medicament delivery device comprising: a housing having a proximal and distal end; a medicament container positioned in the housing and having a medicament delivery member shield; a medicament delivery mechanism associated with the medicament container; an activation member operably connected to the medicament delivery mechanism and longitudinally movable in relation to the housing from an extended position to a retracted position to activate the medicament delivery mechanism; and a removable cap assembly comprising an outer tubular cap body and an inner tubular integrity lock member coaxially coupled to the outer tubular cap body; wherein in a first position of the removable cap assembly, a resilient structure of the inner tubular integrity lock member is engaged to a first engaging structure of the activation member and a second engaging structure of the housing for preventing the activation member from moving into the retracted position.

Abstract: The present disclosure relates to a medicament delivery device comprises: a housing having a proximal end and a distal end; a medicament container positioned in the housing and having a medicament delivery member shield; a medicament delivery mechanism associated with the medicament container; an activation member operably connected to the medicament delivery mechanism and longitudinally movable in relation to the housing from an extended position to a retracted position to activate the medicament delivery mechanism; and a removable cap assembly comprising a deshielder, an inner tubular integrity lock member having a resilient structure configured to interact with both a first engaging structure of the activation member and a second engaging structure of the housing for preventing the activation member from moving into the retracted position; and wherein the removable cap assembly further comprises an outer tubular cap body which is movable in relation to the housing and to the inner tubular integrity lock me

Abstract: A controlled delivery drive mechanism includes a drug container having a barrel and a plunger seal; a drive housing within which at least initially partially resides a piston having an interface surface and a drive rack; and a power spring. The piston is configured to contact and axially translate the plunger seal within barrel. The mechanism may be configured to convert rotational movement of a drive pinion to axial translation of the drive rack, or to convert axial force of a linear power spring into torsional motion of a drive pinion. A regulating mechanism meters the drive pinion such that the piston is axially translated at a controlled rate. The drug container may contain a drug fluid within a drug chamber for drug delivery at a controlled rate. The regulating mechanism may be an escapement regulating mechanism. A drug delivery pump includes such controlled delivery drive mechanisms.

Abstract: A medicament delivery device includes a housing having a longitudinal axis, a container holder, an axially movable plunger adapted to be displaced along the longitudinal axis into the container holder, and an energy accumulating member arranged inside the housing and adapted for displacing the plunger along the longitudinal axis. The plunger includes an outer plunger rod and an inner plunger rod arranged at least partially inside the outer plunger rod, the inner plunger rod being threadedly engaged with the outer plunger rod and manually rotatable to displace the inner plunger rod along the longitudinal axis into the container holder.

Abstract: An injector including at least one fluid reservoir having a needle, a surface attached to skin and coupled to the fluid reservoir by at least a first joint and a second joint at least a portion of one of the joints being slidable or having interlocking arms. At least a portion of a path of translation of a slidable portion of the first joint and a portion of a path of translation of the second joint are angled in respect to each another.

Abstract: An auto-injector device comprises a cap removal mechanism which comprises a retractable component which is slidably mounted within a housing of the device, and a cap-removal actuator to push the retractable component out of the housing to remove a cap from the device; a dispense mechanism which comprises a driving element to expel a medicament from the device; and a dispense button which activates the cap removal mechanism when pressed a first time, engages with the dispense mechanism when released, and activates the dispense mechanism when pressed a second time. The dispense mechanism comprises an engaging element configured to engage with the dispense button when the dispense button has been pressed for a first time and released.

Abstract: A syringe assembly for administration of a neurotoxin, the syringe assembly comprising: a syringe comprising: a clear syringe barrel with dosage markings completely encircling the clear syringe barrel; and a plunger having a plunger body and a clear inverted plunger tip; and a needle assembly comprising a needle and a sealing hub for removably attaching the needle assembly to the syringe, wherein the needle is approximately 0.15 inches to approximately 0.3 inches in length and has a gauge of approximately 27 gauge to approximately 35 gauge.

Abstract: A syringe device for ejecting a dose of a medicament, the syringe device comprising: a dose limiting mechanism arranged to interact with a dose ejecting mechanism to prevent ejection of a dose exceeding a set dose, and a safety mechanism, which is arranged such with respect to the dose ejecting mechanism that, if the dose limiting mechanism fails, the safety mechanism prevents ejection of a dose exceeding the set dose.

Abstract: An injector for ejecting an intraocular lens into an eye, comprises a longitudinal injector body, in which an injector piston rod can be guided in an axially displaceable manner, an injector nozzle at a front end of the injector body, in the direction of which the injector piston rod can be displaced, a displacement mechanism for pushing the injector piston rod forwards, and an actuating element for the manual actuation of the displacement mechanism. The displacement mechanism includes a transmission mechanism, by means of which the actuating element and the injector piston rod can be placed in an articulated driving connection, and an operating region for the actuation of the actuating element is formed at a longitudinal side of the injector body.

Abstract: A drive mechanism for a delivery device comprising a rotator comprising an outer surface and an inner surface, the rotator configured to rotate from a first position to a second position; and a needle cover comprising an inner surface that engages the outer surface of the rotator. An end of injection indication device is positioned at least partially within a plunger rod spring, the end of injection indication device providing a signal to a user of the drive mechanism that an injection has been completed.

Abstract: There is provided drug delivery devices comprising a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

Abstract: An autoinjector having a body (1) receiving a reservoir (S), the reservoir containing fluid and including a piston (P); a piston rod (5) adapted to co-operate with the piston (P) of the reservoir (S), the piston rod (5) movable by an injection spring (8) between a primed position and an injection position in which the piston rod (5) has moved the piston (P) of the reservoir (S); and an indicator device for indicating that the autoinjector may be removed from the injection site. The autoinjector includes a retarding system for delaying actuation of the indicator device relative to the end of injection, the retarding system including a dashpot (16) containing a fluid and a piston (19) arranged in the dashpot (16). The retarding system has the dashpot (16), the piston (19), a retarding spring (18), a locking key (20), and the piston rod (5), and the piston rod (5).

Abstract: An automatic injection device configured for injection of a material stored in a syringe into an injection site, the syringe including a generally cylindrical storage container and a piston disposed therewithin, whose exact initial axial position within the container is not predetermined, wherein axial forward displacement of the piston in the container forces the material forwardly out of the container, the automatic injection device including at least one spring drive assembly operative, when actuated, to initially apply a first axial force to the syringe, thereby to axially displace the syringe in a forward direction, and thereafter, responsive to driving engagement with the piston, to apply a second axial force, substantially greater than the first axial force, notwithstanding the fact that the exact axial position of the piston within the container is not predetermined, to the piston, thereby to axially forwardly displace the piston relative to the syringe.

Abstract: A medical infusion pump can be configured to sequentially inject solutions from multiple syringes. The medical infusion pump can be configured to automatically sequence the injection either by creating differential fluid pressures during injection or by employing a sequencer that creates differential forces on poppets which form seals between different input ports of the sequencer.

Abstract: A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).

Abstract: In an elongated casing, an active agent container connected to an injection needle can be shifted axially by a spring force. Auto-injectors which are sold or distributed filled and with the springs tensed have to be provided with a needle protecting cap to ensure the sterility of the injection needle. When such a needle protecting cap is removed as preparation for using the auto-injector, a tensile force can be exerted on the active agent container. Therefore, the active agent container comprising the injection needle must be prevented from being undesirably pulled forwards. At least one latching tongue prevents the active agent container from being prematurely shifted with respect to the casing, by abutting a flange arranged on a sliding sleeve which accommodates the active agent container. When the auto-injector is placed onto a person's skin, a needle protecting tube is shifted into the casing, forcing the latching tongue away from the flange and, thus, freeing the travel path for needle movement.

Abstract: In some examples, a fluid delivery device is described. The fluid deliver device includes a housing; a reservoir disposed within the housing, the fluid reservoir defining a fluid outlet at a first end of the fluid reservoir; a plunger assembly disposed within the fluid reservoir, the plunger assembly including a friction clutch; and a seal engaged with an interior surface of the fluid reservoir to prevent movement of a material within the fluid reservoir past the seal; and a motive element in communication with a first end of the plunger assembly and configured to apply a motive force on the first end of the plunger assembly towards the first end of the fluid reservoir, wherein the friction clutch is configured to apply a frictional force to the interior surface of the fluid reservoir to resist the motive force, and wherein operation of the friction clutch enables motive force to overcome the frictional force to allow the plunger assembly to translate towards the first end of the fluid reservoir.

Abstract: A syringe having a mechanical ejection mechanism. The ejection mechanism includes an actuator and a rotational gear. The actuator has a retractable pawl configured to engage the gear when the actuator is displaced from a non-depressed position into a depressed position. Displacement of the actuator causes the gear to rotate by a predetermined angle. The rotation of the gear is translated into linear displacement of the plunger within the barrel, thereby ejecting a predetermined amount of solution from the barrel.

Abstract: A fluid delivery device comprises a housing having a fluid reservoir. A needle is in fluid communication with the fluid reservoir in an engaged position and out of fluid communication with the fluid reservoir in armed and storage positions. A proximal end of a biasing member is coupled to the housing and a distal end of the biasing member is configured to deliver a force to the fluid reservoir. A piston member extends through the biasing member and is coupled to the distal end of the biasing member. The piston member is fixed with respect to the housing in a locked position such that the biasing member does not deliver the force to the fluid reservoir and moveable with respect to the housing in a released position such that the biasing member delivers the force to the fluid reservoir. Transitioning the needle from the storage position to the armed position transitions the piston from the locked position to the released position.

Abstract: A drug delivery device is disclosed that includes a housing including a channel, a drug reservoir fitting into the channel, and a friction element extending from a housing to the channel to contact an exterior side wall of the reservoir when the reservoir is inserted into the channel. The friction element is configured and oriented to wedge between the exterior wall and the reservoir when the reservoir is rotated in a first rotational direction.

Abstract: An exemplary embodiment of injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.

Abstract: The present invention relates to a shell assembly for a medicament delivery device, which shell assembly comprises at least one first shell section provided with an entry passage and designed such that at least a major part of a medicament delivery device entered through said entry passage is accommodated inside said at least one first shell section, a closure element operably arranged to said at least one first shell section for closing said entry passage, and fixation elements arranged for fixating said medicament delivery device in relation to said at least one first shell section and said closure element.

Abstract: A medical delivery device for advancing a piston in a medicament container to expel a medicament. A support structure supports the container and a drive assembly that advances the piston. The drive assembly includes a drive ribbon that can be retracted and extended. The retracted ribbon defines a spiral and the extended ribbon defines a helix. The drive ribbon is incrementally moveable between the retracted spiral configuration and extended helical configuration. A mechanical drive rotates the drive ribbon to selectively extend and retract the ribbon. A thrust member having a helical ramp engages a proximal edge of the drive ribbon where it transitions between a spiral and helix. A bearing member at the distal end of the drive ribbon exerts an axial force on the piston when the ribbon is extended.

Abstract: A patch injector (10) for parenteral administration of a drug to a drug recipient has a drug-cartridge module (14) attached to a power-pack module (12) and to a drug-recipient interface module (16). A compressed, elastic power element (18) disposed in the power-pack module (12) is coupled to a plunger (30) movably disposed in a drug reservoir (22) in the drug-cartridge module (14). An injection needle (24) at the distal end of the drug reservoir (22) is oriented orthogonal to the drug reservoir (22) and generally toward a skin-contact surface (28) extending parallel to the longitudinal drug-reservoir axis (22A). The power element (18) is configured to displace the plunger (20) distally into the drug reservoir (22) and to move the injection needle (24) toward the skin-contact surface (28) when the power element (18) expands distally along the drug-reservoir axis (22A).

Abstract: An autoinjector for dispensing a fluid product, in particular a medicament, comprises: a) a housing (2) and a product container (13), in particular a syringe, arranged in the housing and has a piston displaceable in a distal direction, by means of an advancement member, in order to dispense the product contained in the product container, b) a removable covering cap (4) arranged at the distal end of the housing, c) a triggering member (3), which, in the starting position, projects beyond the distal end of the housing, d) where the triggering member, in order to trigger the dispensing operation, can move in a proximal direction relative to the housing from the starting position into a triggering position when the covering cap has been removed from the housing, and e) where the triggering member is blocked against movement into the triggering position when the covering cap is arranged on the housing.

Abstract: An injector includes a trigger mechanism including: a trigger member disposed about an axis having an aperture and a protrusion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to engage the aperture of the trigger member when the trigger member is in a pre-firing condition; an energy source associated with the ram for powering the ram to expel the medicament; and a user-operable firing-initiation member having an aperture engaged with the protrusion of the trigger member and operable for causing an axial translation of the trigger member in a proximal direction from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

Abstract: A drug delivery device includes a housing, a mechanical assembly which is at least partially accommodated in the housing and a retaining member for retaining the mechanical assembly in the housing wherein the retaining member is engaged with the housing such that the device is configured to be damaged when the mechanical assembly or parts thereof are forcefully separated from the housing.

Abstract: A drive mechanism (4) for a drug delivery device comprising—a piston rod (14), —a trigger member (9) coupled with the piston rod (14) in such a manner that rotational movement between the piston rod (14) and the trigger member (9) is constrained in a first state, the trigger member (9) being elastically deformable in such a manner that the piston rod (14) is rotationally moveable with respect to the trigger member (9) in a second state, —a trigger button (10) being suitable for activating the deformation of the trigger member (9).

Abstract: The invention relates to a device for inserting needles, including a body defined by a proximal end and a distal end, a mounting movably mounted inside the body, at least one needle secured to the mounting, a drive means suitable for driving the mounting towards said distal end, said mounting comprising a distal surface onto which the needle projects, said distal end comprising a contact area intended for contacting the tissue, the mounting being configured so as to reach a position, after activating the driving means, in which the distal surface thereof, relative to said proximal end, is more distant than said contact area, wherein the device is further configured so as to enable a gradual passive return movement of the mounting once said position has been reached.

Abstract: A device for drug injection has a cartridge, which in turn has a reservoir and a fluid path. The fluid path carries a fluid for injection from the reservoir to the place where the patient is to be injected. The fluid path comprises a needle, and the fluid path is kept sterile. A drive chain extends the needle to the injection point, but is only mechanically connected to the fluid path to operate the needle, the mechanical connection being such as to operate the needle while maintaining the fluid path sterility.

Abstract: An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

Abstract: The present Invention relates to a kit for applying a liquid composition on or in the skin, comprising an injection device and one or more cartridges, provided with a container appropriate for receiving a liquid composition, in which the injection device is provided with means for receiving a cartridges, characterized in that the container is provided with a movable body. The cartridge is provided with a peripheral edge, that allows the safe removal of a used cartridge out of the device, In a second aspect, the invention relates to a method for applying a liquid composition onto the skin.

Abstract: A spring assisted drug delivery device comprising: a housing; a piston rod having a longitudinal axis, a distal end and a proximal end that is axially movable in a distal direction relative to the housing, a mid-body fixed inside of the housing and coupled to the piston rod in such a manner that the piston rod is axially movable in a distal direction relative to the mid-body, and wherein a preloaded spring is operatively coupled to the piston rod in such a manner that the spring is released and the stored force in the spring supports driving the piston rod in the distal direction during a dose administration step.

Abstract: A treatment system configured to treat a condition using a first fluid, the treatment system including a first reservoir configured to store a first fluid, a cannula insertion mechanism configured to insert a cannula into a user, the cannula in fluid communication with the first reservoir, a first rotatable shaft member configured to pull a first plunger disposed within the first reservoir and coupled to the first rotatable shaft member by a first flexible member, and a drive mechanism having a first expandable member configured to move from a first position to a second position to rotate the first rotatable shaft member to deliver the first fluid to the user through the cannula.

Abstract: A reloadable auto injector has a needle insertion driver to be re-activated upon reloading. A syringe is movably positioned in a housing between a first position and a second position. A plunger rod is locked to a plunger rod tube by a deflectable locking member. A syringe driver applies a force to the syringe to move the syringe together with plunger rod tube, plunger rod and plunger rod driver from the first position to the second position. In the second position, the locking member is unlocked and releases the plunger rod to thereby activate the plunger rod driver to advance the plunger rod in the syringe for delivering of medicament. A reload handle is connected to the syringe assembly so that user operation of the reload handle retracts the syringe to the first position and simultaneously reloads the syringe driver for delivering a further dose of medicament.

Abstract: Embodiments provide apparatus and methods for delivering liquid form medication within the body wherein the medication is stored in solid form and then mixed with a liquid in an apparatus implanted within the body. One embodiment provides an implantable apparatus for in vivo delivery of medication comprising a housing including a reservoir, a store of solid form medication (SSM) and a pump. An SSM element is added to the reservoir along with fluid to form a medication solution comprising at least one drug. The medication solution is then delivered to a delivery site using a pumping means to pump solution from the reservoir through a delivery member such as catheter to a delivery site. Embodiments of the invention are particularly useful for delivering medication to a patient to treat a medical condition over an extended period of time without requiring the patient to take external medication.

Abstract: A device for delivering a bone material to a surgical site is provided. The device comprises a body having an upper portion and a lower portion. The lower portion of the body is substantially transverse to the upper portion and has an opening for receiving a bone material. An internal chamber is disposed within the upper portion and the lower portion, and a plunger is slidably disposed in at least the internal chamber of the body. The plunger has a distal end configured for delivering the bone material out of the lower portion of the body, wherein movement of the plunger in a first position toward the lower portion of the body delivers the bone material from the lower portion of the body to the surgical site. Methods of delivering the bone material are also provided.

Abstract: Disclosed is a transfilling device (1) for transfilling a liquid drug from a cartridge (3) to a flexible reservoir (4). The transfilling device (1) includes a support unit (111) and a plunger (113), the support unit (111) configured to receive the cartridge (3), the plunger (113) being insertable into the cartridge (3), wherein the plunger (113) is displaceable relative to the support unit (111) along an advancement direction (2) between a plunger retracted position, where the plunger (113) is in a most distal position relative to the support unit (111), and a plunger advanced position, where the plunger (113) is in a most proximal position relative to the support unit (111), wherein the plunger (113) is configured to push a piston (32) of the cartridge (3) from a piston retracted position to a piston advanced position by displacing the plunger (113).

Abstract: A dose setting mechanism of a drug delivery device and a respective method of assembling said dose setting mechanism. The dose setting mechanism includes an inner housing having a helical groove along an external surface of the housing. The inner housing includes a rotational stop member near one end of the helical groove. The dose setting mechanism also includes a dial sleeve rotatably engaged with the helical groove of the inner housing. When a user rotates the dial sleeve to select a dose, the rotational stop member prevents the user from selecting a dose greater than a pre-defined maximum selectable dose.