Abstract: A compact and smart wearable device is configured to automatically inject medicines into the wearer. Because hypodermic needles are only deployed when triggered, infection risks are eliminated. Necessary medicines are automatically deployed based on physiological or other data without human intervention to save lives.

Abstract: A drug delivery system for injecting a medicament includes a housing, a container configured to receive a medicament including a stopper configured to move within the container and a closure, a needle in fluid communication with the container, a spacer configured to be engaged with the stopper, a first plunger, a first spring configured to bias the first plunger in an axial direction, second plunger disposed about the first plunger, a second spring configured to bias the second plunger in an axial direction. The first plunger is configured to move the spacer and the container relative to the housing via the first spring to establish fluid communication between the container and the patient needle, and the second plunger is configured to move the spacer and the stopper relative to the container via the second spring.

Abstract: Syringes are described herein. A syringe includes a syringe body, a first plunger, a biasing member, and a retention member. The syringe body defines a syringe cavity and a syringe port, wherein the syringe port is in fluid communication with the syringe cavity. The first plunger comprises a first plunger shaft extending from the first plunger, the first plunger disposed within the syringe cavity and defining a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The biasing member is coupled to the first plunger shaft, wherein the biasing member urges the first plunger to advance toward the syringe port. The retention mechanism prevents the biasing member from advancing the first plunger in an engaged position and permits the biasing member to advance the first plunger in a released position.

Abstract: The invention provides in one aspect a drug delivery device comprising a drug container assembly containing a drug, and a plunger positioned within the container assembly, the drug container assembly having an outlet for dispensing the drug, wherein, in an initial position, the outlet is sealed; a drive mechanism comprising a first stored energy source operable to apply pressure on the plunger or the drug container to pressurise the drug, and a first release mechanism operable to unseal the outlet after the drug has been pressurised.

Abstract: The present invention relates to a mixing and injector device which can include: a housing having a plurality of separate and distinct chambers disposed therein; one or more displacement mechanisms corresponding to each of the plurality of chambers disposed within the housing; a needle assembly being provided about one of the plurality of chambers, the needle assembly including the following: a septum; a needle being separated from the plurality of chambers by the septum, the needle having a proximal end configured to pierce the septum in an actuated state; and a needle carrier, the needle carrier being configured to translate axially with respect to and toward the septum and pierce the septum and provide fluid communication from the plurality of chambers through the needle in the actuated state.

Abstract: A spring release mechanism for a drug delivery includes a fusible member to restrain a spring in a charged state. A heating element is utilized to selectively heat and sever the fusible member. When the fusible member is severed, the spring is allowed to discharge and drive the drug delivery device components operably coupled thereto.

Abstract: A novel single use auto-injector for delivering a fixed amount of medicament is described. The auto-injector may include a sealed housing rotatably held in a cover. Once the auto-injector is positioned at the injection location, the user can transition the housing from a locked to an armed position. The user can then compress the sealed housing into the cover, triggering activation mechanisms that initiate the injection. A first activation mechanism engages an interlock to prevent reuse of the auto-injector. A second activation mechanism straightens and extends a curved needle to a set the exposed needle length. A third activation mechanism pierces a sealed reservoir allowing the medicament to be forced through the injection needle. Following the injection, the auto-injector expands and interlocks, retracting the needle into the auto-injector and preventing reuse.

Abstract: A novel single use auto-injector for delivering a fixed amount of medicament is described. The auto-injector may include a sealed housing rotatably held in a cover. Once the auto-injector is positioned at the injection location, the user can transition the housing from a locked to an armed position. The user can then compress the sealed housing into the cover, triggering activation mechanisms that initiate the injection. A first activation mechanism engages an interlock to prevent reuse of the auto-injector. A second activation mechanism straightens and extends a curved needle to a set the exposed needle length. A third activation mechanism pierces a sealed reservoir allowing the medicament to be forced through the injection needle. Following the injection, the auto-injector expands and interlocks, retracting the needle into the auto-injector and preventing reuse.

Abstract: The invention provides in one aspect a drug delivery device comprising a drug container (16), and a plunger (18) positioned within the container assembly, the drug container assembly having an outlet for dispensing the drug, wherein, in an initial position, the outlet is sealed; a drive mechanism comprising a first stored energy source (42) operable to apply pressure on the plunger or the drug container to pressurize the drug, and a first release mechanism operable to unseal the outlet after the drug has been pressurized.

Abstract: A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes a needle housing with an injection needle. The needle housing is disposed within the housing for moving between a retracted position and an extended position. The device has an injection actuator for commencing an injection cycle including a first stage in which the needle housing and said plunger base are coupled together and move in a first direction along the axis and a second stage in which the needle housing and the plunger base are decoupled from one another so that the plunger base is free to move away from the needle housing in a second direction that is opposite the first direction.

Abstract: The application relates to a vacuum mixing device for bone cement, where the monomer is pressed into a mixing container due to the surrounding vacuum and a gas volume present in the monomer container.

Abstract: An intradermal injection device comprises a housing, a foot with an opening for passage of a needle; a reservoir movably mounted in the housing, and having a hollow space for holding a fluid; a hollow needle movably mounted in the housing and having a first end for penetrating the subject's skin and a second end for penetrating the reservoir, a plunger movably mounted in the housing for moving the needle through the opening for penetrating the subject's skin, and for pressing the fluid out of the reservoir. The reservoir is frictionally mounted inside the housing by first friction means, and the plunger is frictionally mounted to the reservoir by second friction means. The force to overcome the second friction is larger than the force to overcome the first friction.

Abstract: A drug delivery device, including a body having a reservoir disposed therein for containing a medicament, the reservoir including a flexible wall; a plunger movable within the body for causing the medicament to be expelled from the reservoir, the plunger having a contact surface that is not affixed to said flexible reservoir wall; a spring biasing the plunger toward the reservoir; and means for selectively maintaining the plunger in a pre-activated position with respect to the reservoir and, upon releasing the plunger from the pre-activated position, for guiding the plunger to move under the force of the spring such that the contact surface of the plunger contacts the flexible reservoir wall to pressurize the reservoir for delivery of the medicament to a patient.

Abstract: An auto-injection device for delivery of a fluid medicament is provided. The device includes an ampoule having a fluid medicament contained between first and second stoppers; a first sleeve movable along the longitudinal direction relative to the ampoule; a second sleeve at least partially surrounding the ampoule and movable along the longitudinal direction relative to the ampoule; and a needle. The first sleeve is movable along the longitudinal direction relative to the second sleeve and the ampoule between a first position and a second position. The needle is unexposed in the first position but exposed along the longitudinal direction in the second position. The second sleeve is also movable along the longitudinal direction relative to the ampoule between a first position and a second position. The needle is fluidly isolated from the medicament in the first position and is in fluid communication with the medicament in the second position.

Abstract: A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes an injection needle disposed within the housing for moving between a retracted position and an extended position.

Abstract: A prefilled medical injection device with production specific elements is provided as a single use disposable injection device that is optimally suited for mass production through the Blow Fill Seal manufacturing process. The device utilizes a valve and a needle assembly fused to an insert. The valve and the needle assembly are positioned within the insert forming a conduit. The needle assembly is covered with a needle cap that is detachably coupled to protecting the needle assembly from contamination and a user from accidental needle stick. The insert is engaged to the bellows during the BFS manufacturing process and hermetically sealed by a parison layer that covers exterior portion of the insert and the needle cap. The parison layer is formed and trimmed creating exterior features that facilitate the use of the prefilled medical injection.

Abstract: An injection device comprises a housing (101) to (104) containing a syringe (24). The contents of the syringe (24) are viewable through a window (14) in the mid-section (102) of the housing. The window (14) is concealed by a slideable shutter (12). The slideable shutter (12) is biased by a bias spring (22) which also biases an internal syringe carrier. Also disclosed is a reversible needle cap which operates initially to cap the front end of the housing and, upon removal thereof, pulls a needle sheath (30) off the syringe needle (26). The cap is designed to be reversible so that, after use, it can be reversed and reconnected to the housing to cover the exposed needle.

Abstract: A cartridge holder for a drug delivery device is presented comprising a housing extending in an axial direction and being adapted to receive a cartridge at least partially filled with a medicament, said cartridge being sealed near a distal end by way of a pierceable seal. At least one bearing element is fixed to the housing, and at least one tensioning member is engaged with the bearing element and with the cartridge in an axial direction for transmitting a distally directed injection force from the cartridge to the housing.

Abstract: An injection device comprises a first sub-assembly comprising a chamber for holding a fluid and a transfer assembly moveably disposed within the chamber. The chamber comprises an exit aperture and an inner surface and the transfer assembly has an outer surface substantially in contact with the inner surface about its perimeter. The transfer assembly is adapted to transfer fluid into the chamber when the transfer assembly is moved within the chamber.

Abstract: A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

Abstract: A dispensing device for dispensing medicaments to a patient that is made up of first and second stand-alone, interconnectable assemblies. The first of these assemblies comprises a fluid reservoir assembly that houses a fluid reservoir defining component while the second assembly comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first assembly toward the patient via a plurality of fluid flow control passageways. Because the stand-alone fluid delivery and control assembly is initially totally separate from the fluid reservoir assembly of the apparatus, the fluid flow passageways of the fluid delivery and control assembly can be effectively sterilized using conventional gamma ray sterilization techniques without adversely affecting the medicament contained within the fluid reservoir of the apparatus.

Abstract: Remote controls, including a communication device, a button or other communication device actuator and a movable structure that allows actuation of the actuator in one position and prevents actuation of the actuator in another position to prevent inadvertent signal transmission.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible drug container that can be filled in the field with the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A system to minimize fluid turbulence inside a tissue cavity during endoscopic procedures. A body tissue cavity of a subject is distended by continuous flow irrigation using a solenoid operated pump on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by the outflow positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss into the subject's body system during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible, pre-filled drug container that contains the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible, pre-filled drug container that contains the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible, pre-filled drug container that contains the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as analgesics and like medicinal agents from the device reservoir which is provided in the form of a novel bellows-type assembly. The fluid dispenser includes a unique stored energy mechanism that provides the force necessary to continuously and substantially uniformly expel fluid from the device reservoir. The device also includes a novel adjustable flow rate control assembly that is disposed intermediate the fluid reservoir outlet and the outlet port of the device for precisely controlling the rate of fluid flow from the outlet port toward the patient.

Abstract: An infusion media delivery device includes a housing having a base adapted to be secured to a user's skin. An infusion media reservoir is supported by the housing. A moveable hollow needle is selectively engageable with the reservoir to communicate infusion media from the reservoir. The needle is supported for movement relative to the housing base between a first position and a second position. The needle is spaced apart from a user's skin when in the first position and the base is secured to the user's skin, and the needle is arranged to pierce the user's skin when in the second position and the base is secured to the user's skin.

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible drug container that can be filled in the field with the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A method of administering liquid medicine such as epinephrine to a patient includes administering a first dose followed by administering an optional second dose is described herein. Also described herein are devices useful for carrying out the methods described and kits containing these devices.

Abstract: In a device (1) for automatically injecting injection liquids, including an axially subdivided housing whose parts are connectable with each other, wherein an axially displaceable pressure pin (5) is guided in a first housing part (2), which pin is capable of being inserted against a force accumulator (6) and locked in the inserted position and extended upon relief of the force accumulator (6), wherein an injection needle (15) fixed in a needle guide (14) and an ampoule (13) are mounted in a second housing part (3) so as to be axially displaceable relative to each other, wherein the injection needle (15) on its side facing the ampoule (13) is designed as a perforation piece (32) for the ampoule (13), the ampoule (13) with its end facing the injection needle (15) is mounted to reach into a sleeve (16) fixed within the second housing part (3) and whose inner diameter substantially corresponds to the outer diameter of the ampoule (13).

Abstract: A removable, resilient atraumatic sheath for arthroscopic instruments. The sheath covers sharp edges on the arthroscopic instrument, particularly the distal tip of the rigid cannula, and thereby protects tissue and objects near a surgical site from accidental trauma. The sheath may be provided in the form of an inflow/outflow sheath that allows a surgeon to irrigate and drain a surgical field without the use of a separate irrigation instrument.

Abstract: The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by actuation of a user operable release member being positioned at or near an upper end of the injection device, the upper end being that end of the injection device which is opposite the injection needle.

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A multi-well assembly according to one embodiment comprises a multi-well block and a guide plate. The multi-well block defines a plurality of wells, with each well having a fluid-impermeable bottom surface. The guide plate defines a plurality of fluid passageways corresponding to the wells of the multi-well block. The guide plate is configured such that, whenever the guide plate is registered with the multi-well block, fluid communication is established between each well and an associated fluid passageway.

Abstract: The invention concerns a device for automatically injecting injection liquids, comprising an axially divided housing, whereof the parts can be removably assembled. In a first part of the housing (13) is guided an axially mobile pressure pin (14) which can be driven in against a force accumulator (15), which can be locked once it has been driven in and can come out when the force accumulator (15) is released. In a second part of the housing (1) are arranged, axially mobile, an injection needle (4) maintained in a needle guide (5) and an ampoule (3). Said injection needle (4) maintained in the needle guide (5) can be axially mobile, relative to the ampoule (3), and has, on its side facing the ampoule (3), a perforation part (23) designed to perforate the ampoule (3). The second part of the housing (1) can be closed with a top (11) at its open end facing the first part of the housing (13).

Abstract: An automatic injector comprises a housing, a tubular cartridge disposed in the housing, the cartridge having a rearward portion thereof with a predetermined inner diameter and an inwardly extending shoulder connecting a forward portion of the cartridge with a smaller inner diameter than the predetermined diameter. A charge of liquid medicament is normally disposed in the cartridge, and a needle is disposed within the housing and adapted to communicate with the medicament through a forward end of the cartridge to dispense the medicament therethrough. A plunger disposed within the cartridge and rearwardly confines the medicament and has a rearward portion with a diameter sized to form a seal with the predetermined inner diameter of the rearward portion of the cartridge. The plunger is movable forwardly through the cartridge in slidingly sealed relation with respect thereto to displace the medicament through the needle.

Abstract: A self-injection device has a tubular sleeve which is open at its posterior end and partially closed at its anterior end. An ampule sealed at its posterior end by a piston and at its anterior end by a membrane is axially arranged within the tubular sleeve. An injection needle having a terminal flange at its posterior end and an anterior end for piercing the membrane is axially arranged in the ampule. A tubular actuating cap having a piston rod emanating from the bottom of cap for acting upon the piston is slidably guided on the sleeve. The actuating cap and the piston rod are traversed by a central bore having axially extending grooves. The device also includes a locking pin having radially projecting spring tongues. A first segment of the spring tongue extends in an axial direction on the periphery of the locking pin and a second segment is bent at an obtuse angle, extending obliquely outward in a radial-axial direction through the axially extending grooves in the central bore.

Abstract: A disposable, automatic, injector is disclosed which allows self-administration of a medicament to be injected subcutaneously. The injector comprises a barrel (1) with an inner chamber bounded by a liner (2). A first piston (4) and a second piston (11) are provided which may slide within the chamber with a fluid-tight seal with the liner (2). The second piston (11) carries an injection needle (13). A drive means, comprising a compression spring (5) and a releasable retaining collet (6), is provided to act on the first piston (4) to drive it towards the second piston (11). In operation, the drive means urges the first piston towards the second (11). The injection fluid, initially stored between the first and second pistons is incompressible and causes the second piston (11) to move until the needle (13) projects from the end of the barrel (1).

Abstract: The invention relates to an automatic two-chamber injector for mixing and injecting a medical solution. The injector comprises a barrel (11) having a first end with a receiving portion (15) for an injection needle (17), said portion being sealed prior to use, and a second end with a displaceable plunger (27). The barrel (11) comprises two chambers (29, 30) separated by a migrationproof membrane (28), said membrane (28) being adapted to rupture when the plunger (27) is displaced towards the first end of the barrel (11).The invention also related to a method for mixing and injecting a solution by means of an automatic two-chamber injector and to a cartridge for a two-chamber injector.

Abstract: Automatic injection device, as well as ampoule or cartridge for the same. In order to obtain a high speed discharge of an ampoule-hypodermic needle, as well as to ensure an operationally reliable, low weight, robust small apparatus or ampoule at long storability, sterility and re-usability of components for a plurality of injection substances, the needle body (30) of the cannulahypodermic needle (3) is constructed over part of its extension as a needle bearing (31) guided in sliding fit on the inner wall (21) of the cartridge (2). Particularly with a view to administering separate injection substances, it is provided for a cartridge or ampoule with needle and lifting element, that within the ampoule there is arranged a receptacle forming a gas volume, which receptacle can be destroyed easily by initiating the lifting movement and which is resistant to the injection fluid surrounding it.

Abstract: An injection syringe having at least two chambers which are disposed in axis-parallel and juxtaposed relationship and an injection needle in which the needle cavity can be connected to a chamber for an injection liquid which can be pressurized by an injection piston that can be put under load, is intended to provide a syringe construction which is simplified in comparison with the state of the art, for manual handling of the injection piston, as well as mixing of a plurality of injection liquids during the injection operation. For that purpose, the juxtaposed chambers are each provided with an injection piston and communicate with a common prechamber which is formed by a releasable cap carrying the injection needle.

Abstract: A novel syringe is provided herein. It includes a cylindrical barrel having a closed forward end provided with a longitudinally-extending channel therethrough. A hypodermic needle is slidably received in the channel. A frangible septum is disposed in the channel and is adapted to be pierced upon inward sliding movement of the hypodermic needle. At least a single stopper is slidably and sealingly disposed in the barrel to divide the barrel into (i) a forward, payload chamber, defined between the closed forward end of the barrel and the leading face of the stopper, and (ii) a rearward propulsion chamber downstream of the trailing face of the stopper. The propulsion chamber is controllably variably prechargeable to a predetermined gaseous pressure. The syringe may be used with a novel retractable collar and with a novel sliding fin assembly.