Abstract: An improved linear peristaltic pump that is able to be manufactured using fewer parts while also improving the performance and the reliability of the pump. The linear peristaltic pump utilizes a leaf spring in direct contact with a tube and is therefore able to provide smooth transitions in the forces exerted on the tube.

Abstract: Embodiments include methods and systems for maintaining glucose homeostasis. Systems can include a pump, a first reservoir including a homeostasis agent, an umbilical catheter capable of being advanced in the umbilical vein or in the falciform ligament, and a sensor. Systems can also include a biocompatible coating, a microprocessor in communication with the pump and the sensor, and a power supply. Methods can include implanting a pump and reservoir subcutaneously in a patient, advancing a catheter in the umbilical vein or in the falciform ligament, measuring a blood glucose level, pumping a homeostasis agent, and administering the homeostasis agent to the portal venous system.

Abstract: Systems and methods for controlling fluid delivery via a manually administrable medication container to a patient through a fluid delivery pathway are provided. The systems and methods described herein incorporate rules-based clinical decision support logic to drive a flow control valve within a flow pathway based on a determination of whether or not an IV fluid connected to an input port on the pathway is appropriate for patient administration by considering such factors as patient-specific clinical circumstances, current medical orders, and accepted delivery protocols. Related apparatus, systems, methods and articles are also described.

Abstract: A fluid-handling cassette comprising a plurality of diaphragm valves and pumps is configured to have its actuation ports located along a thin or narrow edge of the cassette. Actuation channels within the cassette lead from the actuation ports to actuation chambers of the valves and pumps in a space between plates that comprise the cassette. The individual plates have a nominal thickness that is sufficient to provide a rigid ceiling for the actuation channels, but sufficiently thin to minimize the overall thickness of the cassette. The cassette can be plugged into or unplugged from an actuation receptacle or a manifold by its narrow edge. A plurality of such cassettes can be stacked together or spaced apart from each other to form a cassette assembly, providing for a convenient way to install and remove the cassette assembly from its actuation receptacle.

Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.

Abstract: A system and method for collecting operation data associated with a medical apparatus including an internal device implanted in a subject and an external device that is magnetically-coupled to and drives the internal device. The medical apparatus may be monitored to obtain raw data associated with the operation of the medical apparatus and one or more calculations may be performed on the raw data, wherein the raw data and/or calculated values may be associated with voiding frequency and voiding volume of the subject. A report may be generated from the raw data and/or calculated values. In addition, one or more signals may be sent to the external device and/or a docking station, or communicated by other means, to indicate to the subject that the operation of the medical apparatus should be altered.

Abstract: A medical fluid infusion system includes a pump system configured to deliver a fluid drug to a patient. The system includes a pump, such as a piston pump, for driving fluid to a patient. One or more pressure sensors are configured to measure and detect changes in fluid pressure in a fluid flow line of the infusion system. The changes in fluid pressure, when detected, can be an indication of proper or improper functioning of a valve system of the pump system of the fluid infusion system.

Abstract: The present invention relates to a disposable delivery assembly for a drug delivery device to dispense a liquid medicament, the delivery assembly comprising: a disposable injector (60) comprising an injection needle (65), a flexible tube (64) and an injector fluid coupling (68), wherein the injection needle (65) is in fluid communication with the fluid coupling (68) via the flexible tube (64), a disposable cartridge (70) comprising a reservoir (80) at least partially filled with the liquid medicament and comprising a cartridge fluid coupling (90) in fluid communication with the reservoir (80), wherein the injector (60) and the cartridge (70) are mechanically interconnected in an undeployed configuration (4), in which the injector fluid coupling (68) and the cartridge fluid coupling (90) are disconnected, and—wherein the cartridge (70) is displaceable relative to the injector (60) into a deployed configuration (6), in which the injector fluid coupling (68) and the cartridge fluid coupling (90) are in fluid com

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.

Abstract: An external medical device includes a first cartridge bay with a first cartridge port, a second cartridge bay with a second cartridge port, a fluid outlet in fluid communication with the first cartridge port, a fluid pump configured to deliver a therapeutic fluid from a fluid cartridge engaged with the first cartridge port through the fluid outlet in response to fluid outlet control signals, a fluid inlet in fluid communication with the second cartridge port, and a fluid control structure in fluid communication with the fluid inlet to control fluid flow through the fluid inlet.

Abstract: A pump cassette body for detecting air bubbles in a fluid pathway, comprises an upstanding flow director vane, a fitment integrally molded into the pump cassette body, wherein the fitment comprises a base integrally molded into the pump cassette body, an elastomeric member attached to the base, and a housing at least partially surrounding the elastomeric member, wherein the elastomeric member is co-molded to the housing.

Abstract: The systems, methods and articles described herein are directed to at least one pressure sensor along a downstream fluid line which senses fluid pressure and assists an occlusion detection feature in determining the presence of occlusions in the downstream fluid line. In addition, the system can dynamically adapt the occlusion detection feature based on a delivery of fluid, such as a bolus, in order to prevent the system from creating a false alarm regarding an occlusion of the downstream fluid line.

Abstract: Methods, devices, and systems for laser eye surgery generally make use of a console that interchangeably accepts multiple types of eye treatment cassettes. The cassettes enable one or both of displacement-based or vacuum-based aspiration. The console and the cassette may communicate to establish the functionality of the installed cassette by utilizing a component indigenous to the operation of the cassette. A dual-mode cassette may include a separable holding tank for enabling vacuum-based aspiration. A displacement-based pump may be provided to drain the holding tank while the vacuum system continues to aspirate fluids. A vacuum sensor for controlling the flow of aspirated fluids may have three ports for communicating with a handpiece, a displacement-based pump, a vacuum-based pump, or an irrigation source. The handpiece may be vented during vacuum-based aspiration by opening a vent valve interposed between the handpiece and the vacuum source.

Abstract: Abstract of the Disclosure Implantable drug delivery devices and methods of making and using the same are provided. The implantable drug delivery devices permit selective activation and deactivation of drug delivery while subcutaneously implanted in a patient without the use of electronic equipment or power. The devices include a bistable member that has two stable states. In a first stable state, the bistable member does not close off a fluidic pathway between a drug reservoir and a drug release aperture, thereby allowing drug release from the device. In a second stable state, the bistable member closes off or narrows the fluidic pathway, thereby reducing or preventing drug release from the device. A patient or another person can reversibly change the bistable member between the first and second stable states by applying pressure on the patient's skin over the site of implantation and/or manipulating the device through the patient's skin at the site of implantation.

Abstract: Methods, devices, and systems for laser eye surgery generally make use of a console that interchangeably accepts multiple types of eye treatment cassettes. The cassettes enable one or both of displacement-based or vacuum-based aspiration. The console and the cassette may communicate to establish the functionality of the installed cassette by utilizing a component indigenous to the operation of the cassette. A dual-mode cassette may include a separable holding tank for enabling vacuum-based aspiration. A displacement-based pump may be provided to drain the holding tank while the vacuum system continues to aspirate fluids. A vacuum sensor for controlling the flow of aspirated fluids may have three ports for communicating with a handpiece, a displacement-based pump, a vacuum-based pump, or an irrigation source. The handpiece may be vented during vacuum-based aspiration by opening a vent valve interposed between the handpiece and the vacuum source.

Abstract: The invention generally provides a fluid delivery system comprising: a reservoir (7); a pumping chamber (8) having a volume, an inlet valve (48), an outlet valve (49) and a membrane (47); an actuator (20); and a drive member (21). The inlet valve and the outlet valve each comprise a passive normally closed one-way check valve. The inlet valve provides selective fluid communication between the pumping chamber volume and the reservoir. Fluid in the reservoir is at substantially ambient pressure. The drive member is operatively coupled to the pumping chamber membrane. Energising the actuator moves the drive member in reciprocating motion and thereby displaces the membrane to change the pumping chamber volume between a minimum volume and a maximum volume. The pumping chamber volume is held at a pressure above the ambient pressure in the reservoir when the actuator is at rest.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.

Abstract: A fluid management system for use in a tissue resection procedure includes a controller. An inflow pump is operated by the controller and configured to provide fluid inflow through a flow path to a site in patient's body. An outflow pump is operated by the controller and configured to provide fluid outflow through a flow path from the site in patient's body. A motor driven resecting device may be provided for resecting tissue at the site. The controller is configured to actuate an inflow pump and an outflow pump in response to various signals and various algorithms are provided to provide malfunction warnings and assure safe operation.

Abstract: A pumping chamber (8) for a micro-pump (2), the pumping chamber having a volume of 100 micro litres or less bounded by an interior wall and having an inlet (87) and an outlet (88), wherein the interior wall has at least one inwardly projecting rib (70) having a first end adjacent the inlet and a second end adjacent the outlet.

Abstract: In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.

Abstract: Various systems and methods for detecting air in a chamber of an infusion system are disclosed. In one embodiment, a determination is made that air is contained in the chamber on the basis of a change in the average force exerted against the plunger utilizing a derivative spike for event detection and a systematic reduction in the average force to confirm the nature of the change. In another embodiment, a determination is made that the chamber contains air when a difference between the current force profile and a baseline force profile crosses a threshold. In an additional embodiment, a force profile is classified as being an air force profile or a liquid force profile based on extracted features of the force profile.

Abstract: An assembly for a drug delivery device includes a first member and an attenuation member. The first member includes a main body and an elastically displaceable feature connected to the main body. The attenuation member mechanically cooperates with the elastically displaceable feature to influence the force which has to be exerted on the elastically displaceable feature to displace the elastically displaceable feature elastically with respect to the main body. An attenuation member can be used in a drug delivery device to tune the force required to elastically displace an elastically displaceable feature of a first member of the drug delivery device by bringing the attenuation member into mechanical cooperation with the elastically displaceable feature.

Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

Abstract: A cartridge includes an electrical connection assembly, a first port, a second port, a pumping mechanism, a valve, and a fluid flow sensor. The electrical connection assembly is configured to electrically couple to an electrosurgical unit. The first port is configured to fluidly couple to a fluid source. The second port is configured to fluidly and electrically couple to a surgical instrument. The pumping mechanism is disposed between the first and second ports and is configured to draw fluid from the fluid source and pump the fluid to the surgical instrument. The valve is disposed between the first and second ports and is configured to selectively obstruct the flow of the fluid therethrough. The fluid flow sensor is disposed between the first and second ports and is configured to sense fluid flow therethrough. The fluid flow sensor is configured to electrically communicate with the electrosurgical unit.

Abstract: An aspiration system including a housing containing an aspiration pump, a chamber, a collection bag in fluid communication with the chamber, and a tubing assembly including a first tube portion connected to the chamber. The tubing assembly has a connector to split the first tube portion into a second and third tube portion, the second tube portion in fluid communication with a first catheter to aspirate particles through the first catheter and the third tube portion in fluid communication with a second catheter to aspirate particles through the second catheter.

Abstract: Eliminating leaks of molded fluid channels by providing a front housing, rear housing, and a gasket, wherein the front housing has one or more molded fluid channels and one or more seal channels, and wherein at least a portion of the gasket is located between the front and rear housing; molding the gasket onto the rear housing to create a single unit, wherein the gasket has one or more seal lips configured and dimensioned to couple with the one or more seal channels; and assembling the front housing to the rear housing having the gasket, wherein the one or more seal lips couple with the seal channels. A surgical cassette manifold having a front and rear housing, and a gasket therebetween. The front housing having molded fluid channels that mate with the gasket and the gasket having multiple valves and a sensor/diaphragm accessible through the rear housing.

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set a delivery dose. An injector may include a housing, a cartridge containing a medicinal product, the cartridge being retained within the housing, a dose setting mechanism to select a dose of the medicinal product to be expelled, and a dose delivery mechanism to expel the selected dose of the medicinal product. The housing may be a unitary housing within which the dose setting mechanism and the dose delivery mechanism are moveably retained.

Abstract: A fluid delivery system, method, and apparatus for providing instillation therapy with a negative-pressure source is described. The apparatus includes a housing having an ambient chamber and a negative-pressure chamber fluidly isolated from each other. The apparatus also includes a moveable barrier disposed in the housing between the ambient chamber and the negative-pressure chamber. The moveable barrier is operable to move between a charge position and a discharge position in response to negative pressure. A fluid source is disposed in the negative-pressure chamber and is collapsible in response to movement of the moveable barrier to the discharge position. The apparatus also includes a fluid outlet in fluid communication with the fluid source, a negative-pressure port in fluid communication with the negative-pressure chamber and configured to be coupled to a negative-pressure source, and a vent formed in the housing and fluidly coupled to the ambient chamber.

Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.

Abstract: A pump cassette includes fluid lumen adapted for passage of an infusion fluid toward a patient. A rotary valve assembly can be actuated to regulate fluid flow through the fluid lumen and a frame is coupled to the fluid lumen and the valve assembly. The frame is adapted to be inserted into a seat of a pump device, wherein the frame provides a platen relative to the fluid lumen. The frame is configured to be inserted into the seat only when aligned in a predetermined orientation relative to the seat.

Abstract: A wearable, self-contained drug infusion device is disclosed that is capable of achieving the precise flow rate control needed for dose-critical drugs such as insulin. In preferred embodiments of the device, at least two flow channels are utilized in conjunction with a series of valves for providing a user with selectable, constant flow rate control. The device can be made with small dimensions so that it can be worn by the user with a minimum of discomfort and inconvenience. In addition, the simple mechanical nature of the device provides the user with close control over the flow rate, which is required for safe and effective delivery of insulin and other drugs. Also, the absence of electronic components allows the device to be manufactured inexpensively. The device is provided with a first channel that is long and narrow, functioning as a flow restrictor. The first channel is preferably provided in a serpentine pattern.

Abstract: The invention relates to a device (1) for use in eye surgery, comprising a container (9) with fluid (5) which is connected via an irrigation line (12) to a surgical handpiece for delivering the fluid (5) for rinsing an eye (3) on which surgery has been performed, wherein a pillar (8), which in particular is electrically adjustable in its height, is provided for supporting the container (9) and for adjusting the height (H) between the container (9) and the surgical handpiece, and wherein a control for adjusting the height of the pillar (8) is provided in order to deliver the fluid (5) from the surgical handpiece into the eye (3) at an irrigation pressure predetermined by the surgeon, wherein pressurizing means (10) are provided which are designed for charging the fluid (5) to be delivered from the container (9) to the irrigation line (12) with an atmospheric overpressure (PATÜ) and wherein the control for adjusting the desired irrigation pressure is designed both for adjusting the height (H) of the pillar (8)

Abstract: A system and method for collecting operation data associated with a medical apparatus including an internal device implanted in a subject and an external device that is magnetically-coupled to and drives the internal device. The medical apparatus may be monitored to obtain raw data associated with the operation of the medical apparatus and one or more calculations may be performed on the raw data, wherein the raw data and/or calculated values may be associated with voiding frequency and voiding volume of the subject. A report may be generated from the raw data and/or calculated values. In addition, one or more signals may be sent to the external device and/or a docking station, or communicated by other means, to indicate to the subject that the operation of the medical apparatus should be altered.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

Abstract: A metered liquid droplet inhaling device includes a chassis; a holder releasably connected to the chassis; a container in the holder having a chamber for a composition, an opening for expelling the composition, and a piston; a dose knob accessible outside the chassis for setting a dose to be expelled by accumulating a rotational force; a power supply mechanism for converting the rotational force into an axial force applied to the piston; an activation device connected to the power supply mechanism; a mouth piece connected to the container holder and having a mouth engaging area and an air opening; a droplet generator arranged in the mouth piece and having a plurality of through passing orifices in fluid communication with the opening of the container and with the mouth piece; and a rotation damping member connected to the power supply mechanism for damping an initial pressure peak inside the container.

Abstract: The programmable nursing bottle includes a first housing member configured to hold a liquid therein, a second housing member removably attached to the first housing member and a tube member extending from the first housing portion through the second housing portion. The second housing member includes a pump assembly, a programmable control assembly including an interface, a controller operatively connected to the pump assembly, and a sliding door member provided about the second housing member. The door is configured to slide from a first position in which the interface is exposed to a second position in which the interface is covered.

Abstract: A medicament delivery device includes a generally elongated tubular housing having opposite proximal and distal parts; a needle shield sleeve slidably and coaxially arranged inside the housing with a proximal part of the sleeve protruding a distance outside the proximal part of the housing; a syringe carrier mechanism having a syringe carrier slidably and coaxially arranged within the needle shield sleeve, a syringe having a stopper, a medicament, and a needle, the syringe being coaxially arranged within the syringe carrier; and a holding member connected to the syringe carrier; a first activator member an a second activator member; a drive mechanism adapted to accumulate a drive force for moving the syringe carrier mechanism in a first step and a second step. The second activator member is arranged within an information device for producing audible, visual, and/or tactile feedback to a user about a completed injection.

Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.

Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.

Abstract: Prefilled reservoir apparatuses for use in ambulatory infusion devices include a rigid top and a flexible bag that forms at least a portion of a reservoir containing a liquid medicament composition. The reservoir apparatuses include a septum assembly that includes a fluid flow path in communication with the reservoir and a self-sealing septum disposed in or over the fluid flow path. The septum is positioned and configured to be pierced by a cannula of a base of an infusion device when the reservoir apparatus is received by the base.

Abstract: A dose setting mechanism of a drug delivery device and a respective method of assembling said dose setting mechanism. The dose setting mechanism includes an inner housing having a helical groove along an external surface of the housing. The inner housing includes a rotational stop member near one end of the helical groove. The dose setting mechanism also includes a dial sleeve rotatably engaged with the helical groove of the inner housing. When a user rotates the dial sleeve to select a dose, the rotational stop member prevents the user from selecting a dose greater than a pre-defined maximum selectable dose.

Abstract: The systems, methods and articles described herein are directed to at least one pressure sensor along a downstream fluid line which senses fluid pressure and assists an occlusion detection feature in determining the presence of occlusions in the downstream fluid line. In addition, the system can dynamically adapt the occlusion detection feature based on a delivery of fluid, such as a bolus, in order to prevent the system from creating a false alarm regarding an occlusion of the downstream fluid line.

Abstract: A peristaltic pump squeezes a hose between squeezing rollers and a counter bearing to move fluid through the hose. To compensate for production tolerances and non-uniformities in hose thickness, and to also keep the mechanical loading of the hose as low as possible during the operation of the pump, the spacing between the squeezing rollers and the active surface of the counter bearing can be varied. The counter bearing has a conical or cone-shaped adjusting surface which is supported against a complementarily shaped support surface on the pump housing. The spacing between the squeezing elements and the active surface of the counter bearing can be adjusted by moving the counter bearing relative to the support surface.

Abstract: An apparatus for brewing a beverage has a base arranged to sit on a support surface with the water and ingredients in an upper urn portion until brewed following which the liquid is discharged from the urn through a filter and into a tube passing through the base into a receptacle. A valve in the form of pinch member acting on the tube closes the tube and is released to discharge the beverage by a movable plate mounted on the base and actuated by placing the base on a receptacle. The urn is formed as a separately molded piece from glass so that it is more hygienic than the plastic material of the base. The bottom of the urn fits into a receptacle in the base with a disk shaped seal connecting to the tube.

Abstract: Apparatus for the treatment of the blood, comprising at least one pump (25, 26, 27), matchable with a corresponding portion of tube (35, 36, 37) supported by a cartridge or module (3) which is associated to the apparatus (1), characterized in that it comprises a pump capable of reducing the pressure inside the chamber defined by the association of the cartridge (3) to the apparatus (1).

Abstract: An infusion system includes a double action infusion pump. The pump includes a cylinder and a reciprocating piston received within the cylinder, the reciprocating piston separating a first pump chamber from a second pump chamber of the cylinder. A reciprocating motor is coupled with the reciprocating piston, and the first and second pump chambers alternate between filling and evacuating conditions with reciprocation of the reciprocating piston through operation of the reciprocating motor, and the speed of reciprocation is varied to provide a continuous output of fluid between the first and second pump chambers. A fluid source and a catheter are optionally coupled with the double action infusion pump. The catheter includes one or more infusion ports near a catheter distal portion, and the one or more infusion ports receive and expel the continuous output of fluid from the double action infusion pump.

Abstract: Apparatus for gas delivery (10), particularly at low pressure and volume. The apparatus has a gas reservoir, a delivery line between the gas reservoir (14) and a gas outlet (68) and a first supply line between a first inlet connect able to a first gas supply and the gas reservoir. A pressure control line is provided with an inlet connect able to a second gas supply. The pressure control line is coupled to the gas reservoir to thereby control the pressure in the gas reservoir.

Abstract: An improved elastomeric pump for an infusion assembly. The pump includes a generally cylindrical mandrel body with first end, an opposed second end, a length, an outer diameter corresponding to a first radius (Rmandrel), a central bore extending through the length, a first port extending from the outer diameter to the bore to provide a fluid passageway, a fill port and an exit port in fluid communication with the bore. The pump includes an inflatable elastomeric tube disposed concentrically about the mandrel, the tube being sealingly secured on the mandrel near the respective ends of the tube and having an original inner diameter that corresponds to a second radius (r) so that it approximately matches the outer diameter of the mandrel (Rmandrel), a length (L) less than the length of the mandrel, a wall thickness (t) such that: (0.4225×r)<t?(0.660×r).

Abstract: The present invention involves, in some embodiments, systems and methods involving fluid handling apparatus for pumping fluid to and from a patient, which may include a reusable component and a disposable pumping cartridge. The reusable component may comprise a control chamber and a pressure transducer configured to measure a gas pressure associated with the control chamber, as well as a processor. The processor may be configured to supply the control chamber with a gas at a predetermined pressure, monitor the gas pressure associated within the control chamber with the pressure transducer over a predetermined period of time, and determine if the change in gas pressure associated within the control chamber exceeds a maximum allowable predetermined limit.