Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible, pre-filled drug container that contains the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A tube-positioning system for loading tubing into a peristaltic pump includes a holder and a first tube segment. The holder includes a shell configured to slidably fit onto an exterior of a pump and a pair of guides extending upward from opposite side walls of the shell. The first tube segment has a fixed length and extends between the pair of guides with each end of the first tube segment secured within one of the respective guides.

Abstract: In one aspect, the invention provides methods and apparatus for delivering peritoneal dialysis (PD) solution (or other fluids), from a supply to a patient. A first pump, in fluid coupling with the supply, delivers PD solution from the supply to a “mesne” (or intermediate) measuring element, and generates signals indicative of a volume of that delivered PD solution. The mesne measuring element, in fluid coupling with the first pump, generates signals indicative of a volume of PD solution received from that pump. A second pump, fluidly coupled to the mesne measuring element, routes PD solution from the mesne measuring element for delivery to the patient.

Abstract: A self-contained portable apparatus for administration of a drug solution includes a housing having an enclosure for receiving a flexible pouch containing a drug solution, the output of which is connectable to a conduit for delivering the drug solution to a recipient. A pressurization system is arranged for providing a constant and controllable gas pressure to the housing in order to obtain a controllable delivery of the drug solution. The pressurization system includes a pressure source for delivering positive pressure gas; a pressure accumulation tank connected to the source and the second chamber; a one-way valve arranged between the pressure source and the pressure accumulation tank; and a mechanical pressure regulator arranged between the pressure accumulation tank and the housing. Hereby, an extremely stable and well controllable output pressure and output flow is obtainable.

Abstract: A reservoir for use in a wearable infusion device includes a substantially rigid base having a perimeter, a substantially rigid top having a perimeter, and a flexible rolling diaphragm between the base and the top. The diaphragm has an outer perimeter sealed along the perimeter of the base and an inner perimeter sealed along the perimeter of the top. The diaphragm is arranged to dispose the top and the base immediately adjacent each other when the reservoir is empty and to dispose the top and the base in spaced apart relation when the reservoir is full.

Abstract: A system for controlling administration of medical fluid includes a fluid passageway to which is attached a first flow regulator, a second flow regulator, and a flow detector. The system also includes a controller for controlling the first and second flow regulators in response to a measurement taken by the flow detector of fluid movement in the fluid passageway. The first flow regulator, such as a pump, is configured to maintain fluid movement at flow values greater than an unrestricted flow value. The second flow regulator, such as a variable adjustable valve, is configured to maintain fluid movement at a flow value less than the unrestricted flow value. A method of controlling administration of medical fluid includes obtaining a target flow value, moving fluid through the disposable assembly, taking a measurement of fluid movement in the disposable assembly, and actuating a flow regulating apparatus.

Abstract: A variable hydraulic resistor for use with implantable pumps is disclosed. The variable hydraulic resistor according to the present invention is particularly useful in varying the flow rate of a medication fluid from an otherwise constant flow implantable pump. An implantable pump is also disclosed, which does not require a complicated clinching system or the like, and which may include an undulating membrane and chamber design to reduce the height of the pump.

Abstract: A fluid delivery system includes a fluid container, two or more pressurizing chambers in fluid connection with the fluid container, a drive mechanism in operative connection with the two or more pressurizing chambers to pump fluid from the fluid container and an outlet in fluid connection with the two or more pressurizing chambers. Each of the two or more pressurizing chambers is formed from a flexible, resilient material that is adapted to be compressed to pressurize fluid therewithin.

Abstract: A pump rotor for a roller pump, is disclosed. The rotor comprises: a first roller support comprising a first roller; a second roller support comprising a second roller; an element in the center connected to the first and second roller supports, wherein the first and second roller supports may move angularly with respect to the center element causing distance between the first and second rollers to be varied; first and second positioning elements that connect the first and second roller supports, respectively, to the center element; and first and second spring biased components surrounding first and second positioning elements, respectively, to allow the first and second roller supports to move to allow for automatic adjustment of the rotor.

Abstract: A medical fluid delivery cassette configured for use with a medical fluid pumping system. The cassette includes a base, a membrane attached to the base, and an adhesive disposed on a portion of the membrane overlying a fluid pump chamber of the cassette. The portion of the membrane overlying the fluid pump chamber is moveable such that the volume of the fluid pump chamber can be changed.

Abstract: Programmable infusion systems and method for controlled infusion of diagnostic or therapeutic substances (e.g., drugs, biologics, fluids, cell preparations, etc.) into the bodies of human or animal subjects.

Abstract: An implantable infusion pump system is disclosed. The pump system preferably includes an implantable pump and a removable module. The module may provide for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module preferably includes one or more sensors to determine information relating to the flow rate, electronics for analyzing the flow rate information, and a mechanism for physically altering the flow rate. Methods of dispensing a medicament to a patient are also disclosed, as are variations of the pump system.

Abstract: A device for delivering a liquid including a pump, and an anti-siphon valve external to the pump is disclosed. The anti-siphon valve includes an inlet channel connected to the outlet duct of the pump, and an outlet channel, between which a seat and a moving member are disposed that are suitable for co-operating together and that define, between the inlet channel and the outlet channel, a leaktight liquid flow zone. The moving member is suitable for going from an opening position making it possible for liquid to flow through the flow zone, to a closure position in which the moving member comes into contact with the seat of the valve and prevents any flow through the flow zone, the moving member being subjected to the pressure of a reference chamber that is not in fluid communication with the outlet channel.

Abstract: A roller pump conduit defining a pump chamber is provided. The roller pump conduit includes a roller contact portion having a fill region and a delivery region. The fill region has a first taper configured to determine volume delivery per revolution of a roller head. The delivery region has a pressure region having a second taper and a discharge region having a third taper. The third taper has a lesser degree of taper than the second taper. The delivery region is configured to produce a pulsatile flow out of the conduit. Furthermore, a roller pump having a roller pump conduit is provided. The roller pump conduit of the roller pump has a fill region and a delivery region, the fill region having a first taper, and the delivery region having a second and third taper, wherein the third taper has a lesser degree of taper than the second taper.

Abstract: A medical pump includes a chassis having a fixed seat, and a main carriage having a carriage footing for receiving a fluid delivery device and restricting its movement. An actuator automatically moves the main carriage between open and closed positions to engage the fluid delivery device to the seat. The seat establishes the position of both the main carriage and fluid delivery device in the closed position. The actuator is connected to the main carriage by a rear carriage assembly having a manual release element for disengaging the actuator from rear carriage assembly and thereby from the main carriage. A processing unit detects jam conditions by processing carriage position data and electrical load data from the actuator.

Abstract: A fluid pump apparatus for pumping a fluid from a fluid source to a fluid output comprises a first portion, such as a durable portion, and a second portion, such as a disposable portion. The first portion includes a fluid chamber having a wall and an internal cavity, an input port and an output port. A membrane forms a portion of the wall. The first portion further includes a magneto-sensitive element coupled to the membrane. The second portion comprises an actuator configured to contactlessly induce a reciprocating movement of the membrane by application of a time-varying magnetic field to the magneto-sensitive element, thereby facilitating pumping of the fluid through the fluid chamber.

Abstract: A safety interlock for use in a medical device includes a central tubular portion defining a fluid passage for passing fluid through the safety interlock. An outer ring portion is adapted for mounting on the medical device. The outer ring portion is formed of a light transmitting material and includes at least one interposing surface. A connector portion connects the central tubular portion to the outer ring portion so that the outer ring portion is spaced radially outwardly from the central tubular portion in opposed relation with at least a portion of the central tubular portion. The safety interlock device is adapted for mounting in medical device in a path of electromagnetic radiation from a source of electromagnetic radiation for reflecting the electromagnetic radiation to a electromagnetic radiation detector when properly loaded on the medical device.

Abstract: Fluid delivery apparatus includes a peristaltic pump having an upstream end for receiving a fluid from a fluid source and a downstream end for delivering the fluid to a fluid target. A single pressure sensor is configured to measure, in alternation, an input pressure of the pump at the upstream end and an output pressure of the pump at the downstream end.

Abstract: An infusion pump includes an actuator having an output shaft; a pump actuator having a length (lactuator) moved by the output shaft and in contact with tubing, such that the pump actuator at an output shaft actuated distance (x) creates flat contact areas with the tubing, and wherein remaining non-contact areas of the tubing are at least substantially circular in shape; and a logic implementer configured to use at least two relationships to solve for a same number of variables to calculate a cross-sectional area of the tubing at an output shaft actuated distance (x).

Abstract: A self-contained pump is disclosed that is an integrated pump. It has a reservoir, a pumping mechanism, and at least one outlet. The pumping mechanism is for controlled compression of the reservoir to force a required volume of fluid in the reservoir through the at least one outlet.

Abstract: A fluid delivery system includes a fluid container, two or more pressurizing chambers in fluid connection with the fluid container, a drive mechanism in operative connection with the two or more pressurizing chambers to pump fluid from the fluid container and an outlet in fluid connection with the two or more pressurizing chambers. Each of the two or more pressurizing chambers is formed from a flexible, resilient material that is adapted to be compressed to pressurize fluid therewithin.

Abstract: An ambulatory pump comprising a reservoir (1) for holding the fluid to be pumped and having an outlet (7) through which fluid is expelled in use; a closure (8) device movable relative to the reservoir; and an actuator (14) for moving the closure device relative to the reservoir, wherein the reservoir is arranged in a spiral pattern.

Abstract: A hand-held remote for a medical fluid injector includes a syringe and a conduit which may be coupled to a pressure transducer on a control circuit of the injector. Movement of a plunger within a syringe body on the syringe creates a pressure which is sensed by the pressure transducer and the control circuit responds to the sensed pressure by causing fluid to be ejected from, or drawn into, a syringe mounted to the injector. The pressure developed by the remote provides tactile feedback to an operator for improved control over injections.

Abstract: An irrigation and aspiration tubing system for use with surgical handpieces and irrigation fluid supplies has a flexible tube with first and second lumens formed integrally along its length, with a first lumen used for transporting irrigation fluid to the handpiece and a second lumen used for aspiration of fluid and emulsified particles from a surgical site. The cross-sectional area of the first lumen is selected to provide a cross-sectional area available for fluid flow in excess of the cross-sectional area of a standard surgical irrigation tubes. The system also includes at least one adaptor to allow the tubing to be attached to known surgical handpieces. Preferably, a second adaptor is also provided allowing attachment to sources of irrigating fluid and aspiration vacuum. One said lumen is formed integral with either the interior or exterior surface of the flexible tube.

Abstract: A method and device for measuring and regulating pressure and flow in the spinal canal, in order to characterize individual patient's cerebrospinal fluid (CSF) dynamics. A unique disposable tube-set plate, with computer regulated automated solenoids is used to control flow pressure and the location of a small pressure sensor allows for fully automatic control of the analysis process.

Abstract: A body-insertable apparatus is introduced in a subject to perform at least one of input and output of a predetermined fluid to and from the subject. The body-insertable apparatus includes a reservoir (2) in which the predetermined fluid is stored; a first communicating channel (4) whose one end is opened to an inside of the reservoir, the first communicating channel (4) being extended in a predetermined direction; a second communicating channel (5) whose one end is opened to an outside space of the body-insertable apparatus, the second communicating channel (5) being extended in a direction substantially parallel to the first communicating channel (4), and the second communicating channel (5) partially running parallel to the first communicating channel (4); and a control mechanism (6) which controls a communication state between the first communicating channel (4) and the second communicating channel (5).

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible, pre-filled drug container that contains the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: An apparatus for delivering fluid at a substantially constant flow rate includes a pair of substantially rigid surface elements for defining a volume that is variable according to constrained separation of the pair of surface elements. The apparatus further includes a support member disposed within the volume defined by the pair of surface elements; and a holding reservoir disposed within the volume defined by the pair of surface elements. The holding reservoir is attachably fastened at a first end to the support member and attachably coupled at a second end to the pair of surface elements.

Abstract: An implantable medical device for delivering a therapeutic substance including a housing and a volume sensor assembly. The housing includes a stationary wall and maintains a reservoir containing the therapeutic substance and including a base wall movable relative to the stationary wall such that reservoir volume is a function of a spacing between the base wall and the stationary wall. The volume sensor assembly includes a cap, a shaft, a target, and circuitry. The cap defines a passage extending from an open end, and is mounted to the stationary wall such that the open end is open relative to a stationary wall inner face. The shaft has a first end attached to the base wall and a second end maintaining the target otherwise movably arranged within the passage. The circuitry generates information indicative of a longitudinal position of the target relative to the cap, and thus of the reservoir volume.

Abstract: The implantable drug delivery device comprises at least an implantable pump, a reservoir and a delivery chamber.

Abstract: A dialysis system includes a dialysis instrument; a disposable cassette, the cassette including a rigid portion defining at least one pumping chamber, a pouch fitted over the rigid portion, the pouch including at least one flexible sheet sealed so as to provide a sealed environment inside the pouch; and wherein the instrument is configured to press the at least one flexible sheet against the pumping chamber to seal the pumping chamber for operation.

Abstract: A pumping apparatus and pump set for use to deliver a supply of liquid to a patient. The feeding set has a conduit for the nutrient liquid and a safety interlock device associated with the conduit. The pumping apparatus has a pumping device and a control system for controlling operation of the pump. An electromagnetic radiation source is operatively connected to the control system of the pump for emitting an electromagnetic radiation signal in a direction for striking the safety interlock device of the feeding set. The safety interlock device being adapted to affect the direction of the electromagnetic radiation. An electromagnetic radiation detector is operatively connected to the control system for receiving the electromagnetic radiation signal when the direction is affected by the safety interlock device, and provides an indication to the control system that the feeding set conduit is properly positioned in the feeding pump.

Abstract: A multiple reservoir or chambered implantable pump is disclosed. The pump according to the present invention is particularly useful in allowing for multiple constant flow rates to be provided from an otherwise constant flow implantable pump. The pump is also useful in allowing for housing of multiple active substances. A multiple reservoir implantable pump is also disclosed, which has at least one chamber capable of providing a constant flow rate and at least one chamber capable of being utilized for patient controlled injections.

Abstract: A multiple reservoir or chambered implantable pumps is disclosed. The pump according to the present invention is particularly useful in allowing for multiple constant flow rates to be provided from an otherwise constant flow implantable pump. The pump is also useful in allowing for housing of multiple active substances. A multiple reservoir implantable pump is also disclosed, which has at least one chamber capable of providing a constant flow rate and at least one chamber capable of being utilized for patient controlled injections.

Abstract: The invention provides a finger-type peristaltic pump (2) having a body (4) and a housing (6). The body contains two or more finger-type valves (16) and a processor (22) configured to operate the valves according to a predetermined temporo-spatial pattern. The housing has a passageway (18) configured to receive a conduit. The housing has a first position in which a conduit in the passageway is positioned adjacent to the valve fingers, and a second position in which a conduit in the passageway is not adjacent to the valve fingers. The invention also provides a housing for use in the pump of the invention.

Abstract: Programmable infusion systems and method for controlled infusion of diagnostic or therapeutic substances (e.g., drugs, biologics, fluids, cell preparations, etc.) into the bodies of human or animal subjects.

Abstract: An analyzer enabling the user to hardly breathe in a malodor given off from a reagent when exchanging a reagent container is obtained. This analyzer, connected with a reagent container including a flexible container body storing the reagent, comprises an analyzer body analyzing an analyte with the reagent and reagent transporter having a first end connected to the analyzer body and a second end connected to the reagent container. The reagent transporter includes a first connectional part, detachably connected to the reagent container, having a first switching member forming and blocking a first passage between the analyzer body and the reagent container, while the first switching member blocks the first passage when the first connectional part is separated from the reagent container, and forms the first passage when the first connectional part is connected to the reagent container.

Abstract: An infusion status indicator disposed in the medical infusion line includes a housing with an opening through which the status of the infusion may be determined. A flexible membrane is located at the opening to indicate the status of fluid in the cavity. A recessed flexible membrane indicates insufficient flow of medical fluid into the cavity from the fluid supply, a level flexible membrane indicates correct flow of fluid through the indicator, and a concave flexible membrane indicates an insufficient flow of medical fluid out of the cavity, possibly indicating an occlusion of the fluid line downstream of the indicator. Check valves may be included upstream and downstream of the cavity so that a bolus of fluid may be forced out of the cavity to the patient by pressing the flexible membrane into the cavity.

Abstract: Devices of this invention include replaceable cartridges for delivery of doses of fluids. Cartridges having a fluid supply reservoir comprising an expandable element are designed to be connected with non-disposable actuating module supplied with a sensor, a mechanism to apply a force to the fluid, thereby forcing a predetermined dose out of the reservoir, and a processor providing control outputs from a sensor system according to preprogrammed instructions. Methods of this invention include delivery of microdoses of fluids using devices of this invention.

Abstract: Fluid delivery apparatus includes a peristaltic pump having an upstream end for receiving a fluid from a fluid source and a downstream end for delivering the fluid to a fluid target. A single pressure sensor is configured to measure, in alternation, an input pressure of the pump at the upstream end and an output pressure of the pump at the downstream end.

Abstract: A peristaltic pump includes a conduit having a first end for receiving a fluid from a reservoir and a second end for delivering the fluid. A plurality of fingers are disposed at respective locations along a segment of the conduit and are configured to alternately compress and release the conduit at the locations. A cyclical pump mechanism is coupled to move the fingers between respective compressed and released positions in a spatio-temporal pattern so as to drive a predetermined quantity of the fluid through the segment of the conduit in each pump cycle. A motor is coupled to drive the pump mechanism. A controller is coupled to activate and deactivate the motor in alternation during each pump cycle with a duty cycle that varies within the pump cycle.

Abstract: Programmable infusion systems and method for controlled infusion of diagnostic or therapeutic substances (e.g., drugs, biologics, fluids, cell preparations, etc.) into the bodies of human or animal subjects.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: A pumping apparatus has a peristaltic drive device for pumping a medium through a line that has a compressible portion. The pump contains a one-piece shaft with offset cam segments and lamellae. The shaft may or may not include a core shaft or a continuous core region for an increase in stability. The continuous core region has cam segments offset with respect to one another and contiguous to one another. The ratio between the height and stroke of the lamellae is about 4:1 or less.

Abstract: Programmable infusion systems and method for controlled infusion of diagnostic or therapeutic substances (e.g., drugs, biologics, fluids, cell preparations, etc.) into the bodies of human or animal subjects.

Abstract: A disposable medical cassette apparatus and method for housing medication in a tamper resistant enclosure for selective coupled attachment to an ambulatory infusion pump. In some embodiments, the device may include a first assembly comprising a rear housing and a pressure plate affixed to one another, as well as a second assembly comprising a cover that includes a plurality of lock feature protrusions and at least one slotted aperture. The first assembly and second assembly are adapted for permanent coupling by a first and second lock arrangements. Generally, the first lock arrangement includes lock feature protrusions of the second assembly engaging within the lock receiving structures of the first assembly. Further, the second lock arrangement includes at least one tabbed snap member of the first assembly engaging within at least one corresponding slotted aperture of the second assembly.

Abstract: The invention provides a pump assembly comprising an actuator lever, a supporting structure, a pump comprising a pump member moveable by actuation of the actuator lever, and an actuator for moving the actuator lever. A first stationary pivoting joint is formed between the actuator lever and the supporting structure, and a second floating pivoting joint is formed between the actuator lever and the pump member allowing the pump member to float relative to the actuator lever, the floating pivoting point providing a constant-length actuator arm defined between the first pivoting joint and the second pivoting joint.

Abstract: A vacuum pump capable of pumping solid, liquid and gas, or any combination thereof, including a drive (40) and a manually disengageable pumping system connected thereto. The pumping system is composed of a two- or three-chambered canister (1, 18, 21) within which solids, liquids, and gases can be separated from one another. A highly flexible diaphragm (24) attached to the canister and sealed against it circumferentially, facilitates this separation, when reciprocating and pumping. The components of the pumping system are designed to be disposable, and the two- or three-chambered canister provides for a highly efficient pumping system that is significantly smaller in size than those previously known. The pump is particularly useful for medical applications.

Abstract: A medical fluid flow control system includes an interface including a first pump area, the first pump area of the interface including a pneumatic actuator port and a gasket seal port; and a membrane gasket including a second pump area for mating with the first pump area, the second pump area including a blind section which covers the pneumatic actuator port when the gasket is mated with the interface, the second pump area further including an aperture, the aperture sized and positioned to seal around the gasket seal port, allowing a negative pressure to be applied through the gasket seal port to a flexible sheet of a pumping cassette.

Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament.