Having Plural Material Reservoirs Patents (Class 604/191)
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Patent number: 6726655Abstract: The present invention comprises a medication delivery system for administering an infusion therapy using a medication delivery pump and related fluid container. Medications in a flexible bag of the container are expelled from the bag by the pump into an administration set and delivered to an infusion site. The administration set limits the rate at which a spring compresses the bag. The system provides improved infusion therapy administration which is particularly advantageous for reducing errors, infections and other complications associated with manual infusion techniques.Type: GrantFiled: November 5, 1999Date of Patent: April 27, 2004Assignee: Tandem MedicalInventors: Marc S. Lieberman, Michael W. Kleeman, David R. Brengle
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Patent number: 6726661Abstract: Described is an electronic injection device wherein an electronic circuit is designed to work in two alternative modes: an air shot mode and a dose injection mode. When working in the air shot mode a small predetermined air shot dose is pressed out from the ampule when the injection button is actuated. When working in the injection mode, a dose set by operation of the dose setting means is injected by operation of the injection button. The electronic injection device is normally working in the air shot mode but shifts to work in the dose injection mode when it receives a signal indicating that the dose setting means has been operated. The circuit returns to its air shot mode when receiving a signal indicating that the set dose has been injected. This signal can originate either from a switch indicating that the protection cap is mounted or from a switch indicating that the injection button has been pressed.Type: GrantFiled: December 10, 2002Date of Patent: April 27, 2004Assignee: Novo Nordisk A/SInventors: Jens Munk, Denmark Denmark Aasmul, Henrik Ljunggreen, Lars Hofmann Christensen
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Patent number: 6723067Abstract: An apparatus for delivering aerosolized fibrin endoscopically to a wound is disclosed. The apparatus has a pair of syringes for holding fibrin precursors, a mixing chamber for mixing the fibrin precursors separately with pressurized gas to form individual aerosol solutions, and a delivery tube for delivery of the aerosol solutions to a remote surgical site for formation of an aerosolized fibrin seal.Type: GrantFiled: July 26, 2001Date of Patent: April 20, 2004Inventor: David H. Nielson
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Patent number: 6723074Abstract: A sequential delivery syringe which has an internal chamber located within a body with the internal chamber being substantially closed at one end except for a discharge opening and totally open at the opposite end. A luer is connected to the discharge opening with the luer including a piercing member. A mid-piston is movably mounted within the internal chamber of the syringe with there also being a separate stopper piston which is connected to plunger. Between the stopper piston and the mid-piston is mounted a collapsible structure within which is an internal chamber. A liquid is to be contained within this internal chamber of the collapsible structure.Type: GrantFiled: April 9, 2002Date of Patent: April 20, 2004Inventor: Thor R. Halseth
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Patent number: 6723068Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: September 23, 2002Date of Patent: April 20, 2004Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Ygal, Israil Tsals, Joseph Gross
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Patent number: 6719719Abstract: A spike for facilitating the introduction of liquid under pressure into a container containing a substance is provided which includes an elongate spike shaft having a spike side wall, a longitudinal axis, a distal end and a proximally located end portion, where the distal end has a sharp, pointed tip. An introduction channel is located within the spike shaft for receiving liquid into the container where a portion of the introduction channel is angled to cause liquid to travel out of the introduction channel in a direction non-parallel to the longitudinal axis of the spike shaft. An extraction channel may be included within the spike shaft for removing liquid from the container, where the extraction channel extends through the elongate spike shaft towards the proximally located end portion.Type: GrantFiled: May 23, 2001Date of Patent: April 13, 2004Assignee: Elan Pharma International LimitedInventors: Ehoud Carmel, Gilad Lavi, Gil Yigal, Izrail Tsals
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Patent number: 6719729Abstract: A prefilled telescoping multiple chamber ampoule device separately storing at least two different flowable components includes a container and a piston unit. The container has at least two axially extending chambers with circumferential sealing means projecting inwardly from inner walls of the chambers. The piston unit has at least two pistons and a transversely extending mount integrally adjoining forward ends of the pistons. Each piston has a passage axially extending within its interior as well as an outlet opening at a forward end and a transverse inlet opening near a rearward end. The pistons are arranged for coaxial telescoping movement of the container and the piston unit toward one another from a closed storage position into an open release position. In the closed storage position, the rearward ends of the pistons are spaced from the rearward ends of the chambers so as to define therein reservoirs containing one of the components.Type: GrantFiled: November 8, 2001Date of Patent: April 13, 2004Assignee: Dentaco Dentalindustrie und-Marketing GmbHInventor: Alberto C. Sogaro
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Publication number: 20040068235Abstract: A packaging system for an ophthalmic medical instrument, particularly a punctum plug insertion device having a punctum plug loaded thereon, is provided. The system includes a clear plastic tube containing the device and a sterile barrier end cap enclosing an open end of the tube. The end cap may be provided with visual indicia to indicate a size of punctum plug loaded on the insertion device. In addition, the instrument may be color coded to indicate a size of the plug loaded on the insertion device. A carton is also provided for storing the tubes.Type: ApplicationFiled: October 7, 2002Publication date: April 8, 2004Inventor: Clive T. Hallam
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Publication number: 20040064102Abstract: A syringe for use in ophthalmic surgery includes a pair of barrels and associated plungers which are easily and readily distinguishable by the surgeon allowing for selective and sequential delivery of two different material types through the same device.Type: ApplicationFiled: September 30, 2002Publication date: April 1, 2004Inventor: Akira Yamada
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Publication number: 20040044316Abstract: A syringe for sequentially administering different fluids includes a floating piston which separates the syringe into a first portion for receiving a first fluid to be administered and a second portion for receiving a second fluid to be administered. The floating piston includes a fluid tight seal which initially separates the first and second portions of the syringe and a piercing needle which penetrates the fluid tight seal to connect the second portion of the syringe to the syringe needle after the first fluid has been discharged from the syringe.Type: ApplicationFiled: August 30, 2002Publication date: March 4, 2004Inventor: Christian John Greenfield
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Publication number: 20040039368Abstract: An adapter for connecting a syringe system having a plurality of syringe barrels to an injector having a drive member. The adapter includes an injector attachment, an intermediate drive member including a plurality of plunger drives, and a syringe system attachment. Preferably, each of the plurality of plunger drives is in general alignment with one of the plurality of barrels when the syringe system is attached to the adapter via the syringe system attachment.Type: ApplicationFiled: June 17, 2003Publication date: February 26, 2004Inventors: David M. Reilly, David M. Griffiths
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Patent number: 6692468Abstract: A dual-chamber syringe has a plunger within an inner delivery chamber in fluid communication with an ejection port. The deliver chamber is formed within a tubular element axially slidable within a tubular guide. The tubular guide and the syringe outer barrel form an outer reservoir chamber. The outer reservoir chamber is sealed from the delivery chamber while the tubular element is in a first position within the guide. Upon withdrawal of the plunger, frictional contact imparted by the plunger seal causes the tubular element to slide away from sealing engagement with the barrel into a second position within the guide. In the second position of the tubular element, a fluid passageway is opened from the reservoir to the delivery chamber allowing fluid to be drawn into the delivery chamber. A porous seal between the plunger rod and barrel allows air into the reservoir during transfer of fluid to the delivery chamber.Type: GrantFiled: May 1, 2000Date of Patent: February 17, 2004Inventor: Ottfried Waldenburg
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Patent number: 6689101Abstract: An injector device for delivery of liquid from a high pressure, the device comprising a housing, a pressure chamber 2 comprising a pressure barrel 4 for accommodation of at least one piston therein and having a front end opening 6 for ejection of the liquid, the pressure chamber being of sufficient strength to sustain the liquid pressure. The device further comprises a storage chamber 16, separate from the pressure chamber, for the liquid or the liquid precursor components, and a conduit 22 between the pressure chamber and the storage chamber. A pressurizing mechanism 26 in the housing is arranged to apply force, directly or indirectly, on the piston in the pressure barrel to create said liquid pressure.Type: GrantFiled: May 22, 2001Date of Patent: February 10, 2004Assignee: Pharmacia ABInventors: Birger Hjertman, Jonas Fridholm
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Patent number: 6656162Abstract: Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release.Type: GrantFiled: December 9, 2002Date of Patent: December 2, 2003Assignee: MicroCHIPS, Inc.Inventors: John T. Santini, Jr., Charles E. Hutchinson
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Patent number: 6656150Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The injection device includes a housing assembly, a dry compartment located within the housing for storing a predetermined dry charge of dry medicament therein, and a wet compartment located within the housing for storing a predetermined amount of liquid injection solution therein. The injection device further includes an activation assembly that enables the pressurization of the liquid injection solution in the wet compartment. The activation assembly also enables the compression of the dry medicament within the dry compartment upon activation of the automatic injection device.Type: GrantFiled: October 9, 2001Date of Patent: December 2, 2003Assignee: Meridian Medical Technologies, Inc.Inventors: Robert L. Hill, John G. Wilmot, Steven M Griffiths
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Patent number: 6648852Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.Type: GrantFiled: March 27, 2003Date of Patent: November 18, 2003Assignee: 3M Innovative Peroperties CompanyInventors: David F. Wirt, Larry H. Dodge, Jeffrey D. Smith
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Patent number: 6645181Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: November 11, 2003Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
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Patent number: 6645179Abstract: An injection syringe generally comprised of a multichambered cylindrical ampule, a tripartite case of a front case; a middle case; a rear case, and a needle-holder, and a plunger: the multichambered cylindrical ampule including two chambers of a front space and a rear space, the front space being sealed forwardly with a packing penetrable by a needle and sealed rearwardly with a movable front gasket, and the rear space being sealed forwardly with the front gasket and sealed rearwardly with a movable rear gasket, and the ampule also including a bypass route longitudinally arranged on inner surface of the ampule such that the front gasket is located to take a position rearwardly apart from the bypass route before dissolution of a solid medicine, wherein the front space for admission of the solid medicine is separated from the rear space for admission of a medicinal solvent or dispersing agent; the middle case also including a short thread or fixer means provided externally at midportion thereof, and the rear caType: GrantFiled: July 6, 2000Date of Patent: November 11, 2003Assignee: Nihon Chemical Research Co., Ltd.Inventors: Hiromichi Ishikawa, Shinichi Koni
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Patent number: 6641566Abstract: A medication injection or delivery system is provided for injecting fluids such as insulin within body tissue. The device includes a housing, a flexible shaft movably mounted within the housing, and a dose setting mechanism for controlling the movement of the shaft with respect to a fluid-containing cartridge removably positioned within or mounted to the housing. The flexible shaft, according to exemplary embodiments, includes a plunger and a flexible cable connected to the dose setting mechanism. The plunger and dose setting mechanism are connected together by the flexible shaft. The dose setting mechanism, in one aspect of the invention, includes a screw, a locking mechanism, and a nut assembly connected to the flexible shaft. The dose setting mechanism is used to set the dosage and prime the catheter. The plunger retracts into a recess to permit a new cartridge to be installed quickly.Type: GrantFiled: June 24, 2002Date of Patent: November 4, 2003Assignee: Sterling Medivations, Inc.Inventors: Joel Douglas, John Ramirez, Robert Hugo
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Publication number: 20030199816Abstract: There is provided a pre-loaded multi-chamber syringe including an elongated hollow tube having first and second ends. The first end of the tube receives a needle support and the second end of the tube receives a plunger assembly. A moveable gasket is received between the one end of the plunger assembly and the first end of the tube thereby forming first and second chambers. Each chamber receives a liquid. A hollow needle extends from the needle assembly initially into the first chamber. When the plunger is depressed, the liquid from the first chamber is expelled through the hollow needle and the gasket moves to come in contact with the hollow needle wherein the hollow needle penetrates the gasket and thus extends into the second chamber so that the liquid from the second chamber is then expelled through the hollow needle.Type: ApplicationFiled: April 17, 2002Publication date: October 23, 2003Inventor: Scott Ramming
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Patent number: 6623457Abstract: A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5-250 microns and generally about 50-100 microns.Type: GrantFiled: September 22, 1999Date of Patent: September 23, 2003Assignee: Becton, Dickinson and CompanyInventor: Zeil B. Rosenberg
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Patent number: 6620125Abstract: A method and a device for mixing at least two liquid components of different viscosities of a multi-component material, such as a tissue adhesive, during application thereof, are disclosed, the components being pressed out of separate containers, mixed, and applied by aid of an application part, e.g. a cannula, the less viscous component being directly pressed into the flow of at least one other, more viscous component.Type: GrantFiled: March 17, 2000Date of Patent: September 16, 2003Assignee: Baxter AktiengesellschaftInventor: Heinz Redl
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Patent number: 6612465Abstract: A multi-component, mixing, storage and dispensing package (10) has a housing 11, a displaceable cavity block (20) having at least one cavity (21) therein. A vent spike block (40) having at least one spike (42) held in an opposing relation to at least one cavity (21) is provided within the housing (11). When cavity block (21) is caused to move toward the vent spike block (40) spike (42) is caused to enter a cavity (21). A vent (43) is in fluid communication through the spike (42) with a mix channel (51) and a mixing and dispensing tip (50).Type: GrantFiled: April 11, 2002Date of Patent: September 2, 2003Assignee: Dentsply Research & Development Corp.Inventors: Paul R. Pierson, Paul D. Hammesfahr
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Patent number: 6613020Abstract: A novel device and method for applying two or more liquid components, for example fibrin sealant-forming components, comprises sources of the components fliud communication with, but remote from, an applicator for delivering the components to a desired site. Preferably, the user of such a device and method can actuate the application of the components by providing a signal to a controller which dispenses components from their sources to, and out of, the applicator. Greater ease, accuracy and control are realized by the user since the sources of components and controller are remote from the applicator and therefore not manually held by the user.Type: GrantFiled: December 6, 1996Date of Patent: September 2, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Niels Erik Holm, Allan Garbasch, John E. Fairbrother, Frank Castellana
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Patent number: 6613021Abstract: Ampoule for dispensing a substance comprising: a container having a chamber therein for storing a substance to be dispensed; a piston arranged in the chamber so as to be displaceably in longitudinal correction of the chamber; an outlet means which can be connected to the container such that a fluid communication is established between an inlet portion of a discharge passage of the outlet means and an outlet opening of the chamber; and a plug closure means being insertable in a fluid-tight manner into the outlet opening of the chamber and, when it has been fluid-tightly inserted into the outlet opening, being displaceable by the outlet means connected to the container in direction towards the interior of the chamber from a closed position into an open position in which a fluid communication is provided between the interior of the chamber and the inlet portion of the discharge passage of the outlet means via the outlet opening of the chamber, the plug closure means having retaining means retaining the plug closType: GrantFiled: October 31, 2001Date of Patent: September 2, 2003Assignee: Dentaco Dentalindustrie und-marketing GmbHInventor: Alberto C. Sogaro
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Patent number: 6613010Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the liquid from the housing at a speed sufficient to pierce an injection surface. In one embodiment, the needle-less injector includes a mechanism for mitigating the kickback associated with releasing compressed gas from the engine. In another embodiment, the housing includes finger rests that provide stability and resistance to activate the device. In another embodiment, the engine is fitted with a reusable valve.Type: GrantFiled: April 13, 2001Date of Patent: September 2, 2003Assignee: PenJet CorporationInventor: Thomas P. Castellano
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Patent number: 6607512Abstract: The present invention provides a novel apparatus for delivering a liquid or gel-like surgical material to a target site within a body cavity. The apparatus is characterized in part by an elongated structural member adapted for engagement with a conventional syringe and cannula assembly. In preferred embodiments of the present invention, devices of the invention further comprise a highly flexible applicator tip which permits application of the surgical material at variable delivery angles and even against gravity. Methods also are disclosed for applying the surgical material to the target site using. devices of the present invention.Type: GrantFiled: January 9, 2001Date of Patent: August 19, 2003Assignee: Genzyme CorporationInventors: Dana A. Oliver, Lawrence F. Travers
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Patent number: 6605066Abstract: A device for the formation and delivery of a mixture, notably a surgical adhesive, consisting of a receptacle adapted for easy handling by the surgeon, and including the means of receiving two syringe barrels containing the constituents of the mixture, the means of simultaneously expelling the contents, the means of maintaining the contents of syringe containing the first constituent, at a predetermined temperature setting which is higher than body temperature, and a mixer simultaneously receiving the contents of the two syringes, and the mixer also being used for cooling.Type: GrantFiled: August 29, 2000Date of Patent: August 12, 2003Assignee: Imedex BiomateriauxInventors: Philippe Gravagna, Jean-Louis Tayot
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Patent number: 6585696Abstract: An applicator gun for spraying a medically useful multiple component fluid to an area of interest. The handheld applicator gun functionally receives a commercially available or standardized multi-syringe applicator, and dispenses fluid from the multi-syringe applicator in a controllable manner. The handheld applicator gun further includes a return stop and a dispensing stop to limit the force exerted on the multi-syringe applicator.Type: GrantFiled: December 22, 2000Date of Patent: July 1, 2003Assignee: Baxter International, Inc.Inventors: Robert L. Petersen, James C. Laird, Jorge Delcastillo, Jacquelynn Welter, Atif M. Yardimci
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Publication number: 20030120217Abstract: In a method for sclerotherapy for treating varicose veins, a flushing solution, such as sterile saline solution, is initially injected into the vein or vessel being treated. The flushing solution displaces or flushes out blood from the treatment site of the vessel. A sclerosing agent is then injected into the treatment site. The displacement of blood before introduction of the sclerosing agent reduces complications. A syringe assembly useful for performing the method has first and second reservoirs sealed off from each by an end cap. The end cap is removed just before use. A needle is attached and is connected to both reservoirs. Flushing solution is delivered from the first reservoir followed by sclerosing solution delivered from the second reservoir, without removing the needle from the vessel. A system or kit for combining and holding two syringes, to provide two different injectants into the same injection site, includes a collar holding two (or more) syringes together.Type: ApplicationFiled: February 11, 2002Publication date: June 26, 2003Inventor: R. Patrick Abergel
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Publication number: 20030120201Abstract: In a method for sclerotherapy for treating varicose veins, a flushing solution, such as sterile saline solution, is initially injected into the vein or vessel being treated. The flushing solution displaces or flushes out blood from the treatment site of the vessel. A sclerosing agent is then injected into the treatment site. The displacement of blood before introduction of the sclerosing agent reduces complications. A syringe assembly useful for performing the method has first and second reservoirs sealed off from each by an end cap. The end cap is removed just before use. A needle is attached and is connected to both reservoirs. Flushing solution is delivered from the first reservoir followed by sclerosing solution delivered from the second reservoir, without removing the needle from the vessel.Type: ApplicationFiled: December 21, 2001Publication date: June 26, 2003Inventor: R. Patrick Abergel
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Patent number: 6575205Abstract: A method and apparatus for filling a syringe-type applicator having multiple material reservoirs are disclosed. The method and apparatus permits the individual component reservoirs to be simultaneously filled without risk of contamination or unintentional component mixing. The method and apparatus are particularly useful in the preparation and delivery of multiple component tissue sealants such a fibrinogen adhesive compositions.Type: GrantFiled: December 7, 2000Date of Patent: June 10, 2003Assignee: Baxter InternationalInventors: Gordon Howard Epstein, Alan Plyley, Russell James Redmond
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Patent number: 6575940Abstract: A sealant applicator suitable for dispensing a coagulable sealant, for example a two-component fibrin sealant mixed in the applicator, employs impulse clearing to remove residual coagulated or coagulating material from the dispensing pathway and mixing chamber, if present. Impulses may be generated by manual application of a clearing member such as a plunger which can enter into the dispensing pathway to engage, dislodge and discharge residuals or can generate a gas impulse to impact the residuals to similar effect. A clearing valve having a clearing port can be operated by movement of the clearing member to provide access to the dispensing pathway.Type: GrantFiled: May 20, 1999Date of Patent: June 10, 2003Assignee: Baxter Healthcare CorporationInventors: Mitchell E. Levinson, Gordon Howard Epstein
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Publication number: 20030105433Abstract: A syringe or cartridge having a hollow barrel with an open end and a second end suitable for attaching a needle assembly. A master plunger assembly that includes a master plunger and a plunger member is mounted in the barrel for longitudinal movement therein. A slave plunger is mounted in the barrel for longitudinal movement therein, and is located between the master plunger assembly and the second barrel end so as to define two chambers. The first chamber a liquid chamber and is between the slave plunger and the second barrel end, and the second chamber is a pneumatic chamber and is between the slave plunger and the master plunger assembly. The liquid-containing chamber is suitable for containing a liquid to be dispensed from the syringe, and the pneumatic chamber contains a gas such as air.Type: ApplicationFiled: November 30, 2001Publication date: June 5, 2003Inventor: Philip H. Ruben
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Patent number: 6569113Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.Type: GrantFiled: August 9, 2002Date of Patent: May 27, 2003Assignee: 3M Innovative Properties CompanyInventors: David F. Wirt, Larry H. Dodge, Jeffrey D. Smith
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Patent number: 6565539Abstract: The device for applying a flowable medium, in particular a tissue adhesive is provided with at least one reservoir (16) for the medium, wherein said reservoir (16) comprises an outlet (22) from which the medium exits when pressure is applied to the medium and/or said reservoir (16). A pressure-generating element (20) acts upon the medium and/or said reservoir (16) and is biased by a biasing means (34). Said biasing means (34) can be locked with the aid of a controllable locking means (58), wherein said locking means (58) comprises a movable fixing element (54) which, in at least one fixing position, locks the biasing element (34) against movements caused by the biasing process, and is movable out of the at least one fixing position to release said biasing element (34).Type: GrantFiled: February 12, 2002Date of Patent: May 20, 2003Assignee: OMRIX Biopharmaceuticals SAInventors: Freddy Zinger, Igor Denenburg, Benny Kutal
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Patent number: 6544233Abstract: A pre-filled syringe includes an outer cylinder having a sealed nozzle, and an inner cylinder movable forward and rearward in the outer cylinder and forming a first space between the inner cylinder and an inner front end of the outer cylinder. A first gasket is slidably accommodated in the inner cylinder in a liquid-tight state, a second gasket is accommodated slidably in the inner cylinder in a liquid-tight state and is located rearward from the first gasket to form a second space between the first and second gaskets, and a plunger is attached at a rear end of the second gasket. A third gasket is installed near the front end of the inner cylinder to be slidable in a liquid-tight state between the inner and outer cylinders. A first medicine is stored in the first space and a second medicine is stored in the second space.Type: GrantFiled: October 18, 2000Date of Patent: April 8, 2003Assignee: Terumo Kabushiki KaishaInventors: Hideo Fukui, Masato Nishimura
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Patent number: 6537242Abstract: A device for monitoring, sampling or delivering a substance to the skin of a patient includes a medical device and a stretching device for stretching the skin to enhance the contact by the medical device. The medical device generally includes at least a skin penetrating member, such as a cannula. The cannula can be a single needle or an array of microneedles. The method for monitoring, sampling or delivering a substance positions the device on the skin and presses downwardly on the device causing the stretching device to stretch the skin in a target area of the skin penetrating member to enable uniform penetration of the skin. The uniform penetration provides for a more uniform monitoring, sampling or delivery of the substance to the patient.Type: GrantFiled: June 6, 2000Date of Patent: March 25, 2003Assignee: Becton, Dickinson and CompanyInventor: Phyllis J. Palmer
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Patent number: 6537256Abstract: Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release. The apparatus and methods provide for active or passive controlled release of the molecules. Embodiments include systems for release of fragrance molecules and beverage additives.Type: GrantFiled: July 15, 2002Date of Patent: March 25, 2003Assignee: MicroCHIPS, Inc.Inventors: John T. Santini, Jr., Charles E. Hutchinson, Scott A. Uhland, Michael J. Cima, Robert S. Langer, Dennis Ausiello
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Publication number: 20030055384Abstract: Fibrin sealant applicator systems are provided for dispensing a first and a second protein solution to form a biological adhesive which overcome the disadvantages of the prior art. The first and second protein solutions are preferably fibrinogen and thrombin solutions which may intermix on an application site or within the applicator to form a fibrin sealant. The fibrin sealant applicator systems according to the present disclosure include two piston-type sub-assemblies coupled to two vials storing the fibrinogen and thrombin via a coupling unit. The piston-type sub-assemblies store sterilized water within reservoirs which are in fluid communication with the vials via the coupling unit. The water is forced into the vials to form the fibrinogen and thrombin solutions.Type: ApplicationFiled: October 28, 2002Publication date: March 20, 2003Applicant: United States Surgical CorporationInventors: Karl Enrenfels, Clifford L. Emmons, Chad Cimini, Csaba L. Reth, Tim Van Leeuwen
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Patent number: 6527750Abstract: A medication administration system includes an application assembly having a syringe assembly coupled within the application assembly. A trigger handle of the application assembly is operationally coupled to the syringe assembly such that actuation of the trigger handle actuates the syringe assembly. The syringe assembly is for administering medication to an animal. A needle assembly is in fluid communication with the syringe assembly. The needle assembly is for piercing the hide of the animal such that the syringe assembly is adapted for applying medication to a blood stream of the animal. A sling assembly is for carrying a medication supply assembly. The sling assembly is adapted for selectively coupling to a user. The medication supply assembly is in fluid communication with the syringe assembly such that the medication supply assembly is adapted for supplying medication to the syringe assembly.Type: GrantFiled: June 8, 2001Date of Patent: March 4, 2003Inventor: Daniel W. Frandsen
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Patent number: 6527749Abstract: An applicator is provided for dispensing a first and a second protein solution to form a biological adhesive where the solutions can be deflected by a deflection assembly during dispensing for the adhesive to cover a broad or limited area. The applicator includes a housing having a housing head for enclosing therein a first reservoir containing a first component, and a second reservoir containing a second component. The first and second components are preferably fibrinogen and thrombin which intermix with water to form the first and second protein solutions, respectively. The housing further includes an elongated body portion defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. The solutions intermix on an application site to form a fibrin sealant. In an alternate embodiment, the applicator includes two valves.Type: GrantFiled: June 19, 2000Date of Patent: March 4, 2003Assignee: United States Surgical CorporationInventors: Mark S. Roby, Ernie Aranyi, Richard Yagami, H. Jonathan Tovey
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Publication number: 20030040701Abstract: A dual chamber syringe in which a dual function piston divides the syringe into two compartments containing powder or fluid in one compartment and fluid in the other. For mixture of the two substances, a passage is opened between the two compartments before or during retraction of the piston to force the substances to be mixed in the front compartment. During forward movement of the piston, the passage between the two compartments is closed to force the mixture of substances through the discharge opening of the syringe.Type: ApplicationFiled: August 14, 2002Publication date: February 27, 2003Inventor: Asger Lau Dalmose
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Publication number: 20030032925Abstract: An elongated syringe for administering a substance to a patient includes an elongated syringe chamber that may be inserted into a duct of a patient without unwantingly injuring the patient, a needle extending from the distal end of the syringe chamber, and a plunger rod extending from the proximal end of the syringe chamber. The syringe chamber may be flexible to accommodate curvatures of the duct of the patient. The syringe chamber includes a plurality of chamber compartments that will contain a fluid. At least one of the chamber compartments contains a fluid that is administered to a patient. The syringe chamber may include a driving piston located between two or more chamber compartments. The needle of the syringe may be a component of a transition-bore needle apparatus to facilitate delivery of a relatively viscous fluid from the syringe. The needle may also be flared at its proximal end so that the diameter of the proximal end of the needle is greater than the diameter of the distal end of the needle.Type: ApplicationFiled: July 24, 2002Publication date: February 13, 2003Inventor: Corbett Stone
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Publication number: 20030028142Abstract: A multifunctional device administering medicinal substances, comprising a cannula (10), suitable for administering a medical product (15), and a container and separator of substances (20), capable of being applied to one of the ends (14) of said cannula (10). The cannula (10) comprises a cylinder or tube (11) for containing the medical product and a thrusting piston (12) which can move, through a shaft (13), inside the tube (11), whereas the container-separator of substances (20) comprises a capsule (21) made of deformable material and a separator element (22), shaped as a regulator, suitable for closing the concave part of the capsule (21), so as to avoid the mixing of a liquid, powdered or granulated solute, contained therein, with the solvent consisting of the medical product (15), before the application of the compound. The mixing of the solvent and the solute takes place by deforming the capsule (21) and removing the separator element (22).Type: ApplicationFiled: July 24, 2002Publication date: February 6, 2003Inventor: Alessio Nobbio
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Patent number: 6514230Abstract: Described is an electronic injection device wherein an electronic circuit is designed to work in two alternative modes: an air shot mode and a dose injection mode. When working in the air shot mode a small predetermined air shot dose is pressed out from the ampule when the injection button is actuated. When working in the injection mode, a dose set by operation of the dose setting means is injected by operation of the injection button. The electronic injection device is normally working in the air shot mode but shifts to work in the dose injection mode when it receives a signal indicating that the dose setting means has been operated. The circuit returns to its air shot mode when receiving a signal indicating that the set dose has been injected. This signal can originate either from a switch indicating that the protection cap is mounted or from a switch indicating that the injection button has been pressed.Type: GrantFiled: September 28, 2000Date of Patent: February 4, 2003Assignee: Novo Nordisk A/SInventors: Jens Munk, Denmark Denmark Aasmul, Henrik Ljunggreen, Lars Hofmann Christensen
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Patent number: 6511463Abstract: Microneedle arrays are fabricated by providing a sacrificial mold including a substrate and an array of posts, preferably solid posts, projecting therefrom. A first material is coated on the sacrificial mold including on the substrate and on the array of posts. The sacrificial mold is removed to provide an array of hollow tubes projecting from a base. The inner and outer surfaces of the array of hollow tubes are coated with a second material to create the array of microneedles projecting from the base. The sacrificial mold may be fabricated by fabricating a master mold, including an array of channels that extend into the master mold from a face thereof. A third material is molded into the channels and on the face of the master mold, to create the sacrificial mold. The sacrificial mold then is separated from the master mold. Alternatively, wire bonding may be used to wire bond an array of wires to a substrate to create the sacrificial mold.Type: GrantFiled: November 18, 1999Date of Patent: January 28, 2003Assignee: JDS Uniphase CorporationInventors: Robert L. Wood, Henry A. Wynands, Karen W. Markus
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Patent number: 6508791Abstract: An infusion apparatus comprises a plurality of ports, a plurality of one-way directional valves, and a joint. Each port is adapted to receive and secure a syringe to allow for a flow of a liquid through the syringe into the port. Each one-way directional valve is in fluid communication with a respective port of the plurality of ports to enable the liquid to flow away from the port. The joint has a plurality of inputs to receive the flow from the plurality of one-way directional valves. The inputs are in fluid communication with each individual port of the plurality of ports. The joint has an output.Type: GrantFiled: January 28, 2000Date of Patent: January 21, 2003Inventor: Ramon Guerrero
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Patent number: 6503231Abstract: Microneedle devices for transport of therapeutic and diagnostic materials and/or energy across tissue barriers, and methods for manufacturing the devices, are provided. The microneedles are hollow and/or porous and have diameters between about 10 nm and 1 mm. The microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Microfabrication techniques are used to cost-effectively produce arrays of microneedles from metals, silicon, silicon dioxide, ceramic, and polymeric materials. Methods are provided for making porous or hollow microneedles.Type: GrantFiled: June 10, 1998Date of Patent: January 7, 2003Assignee: Georgia Tech Research CorporationInventors: Mark R. Prausnitz, Mark G. Allen, Devin V. McAllister, Sebastien Henry
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Publication number: 20030004118Abstract: Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first active ingredient are packaged within and dispensed from a common dispenser. By packaging these two active ingredients in this manner, long shelflife and convenient dispensing and application are provided.Type: ApplicationFiled: April 12, 2002Publication date: January 2, 2003Inventors: Mohan Vishnupad, Naomi Vishnupad