Abstract: An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).

Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament (2) and where both medicaments are delivered through a single hollow needle (5). The medicated module (4) is user selectable so that it will deliver both the primary (1) and secondary medicaments (2), or only the primary medicament (1). The module (4) also contains a guard (42) that locks after dose delivery.

Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments (1, 2) is disclosed where a primary delivery device (7) containing a primary medicament (1) accepts a medicated module (4) containing a single dose of a secondary medicament (2) and where both medicaments (1, 2) are delivered through a single hollow needle (3, 16, 21, 31).

Abstract: The invention provides a syringe for dispensing a drug (1), comprising: a rigid syringe body,—a first container (2), in contact with and enclosing the drug; and a second container (3), enclosing the first container, the second container being less gas permeable than the first container, wherein the second container partially or fully forms the rigid syringe body or is held within the rigid syringe body. The invention preserves the drug but allows the drug to be easily accessed without the need for a user to remove a gas barrier structure as a separate action in addition to the other actions needed to deliver the drug.

Abstract: A syringe adapter mountable to a syringe, particularly a retractable syringe having a retractable needle, comprises a sealing member and an adapter body that comprises two or more body members that co-operate to retain the sealing member in the adapter. One or the other body members is removably mountable to a barrel of the syringe and one or the other body members comprises a mounting member. A filter member may be removably mounted to, or formed integrally with, the mounting member to filters fluid when filling the syringe to thereby remove particular material, impurities or the like. Alternatively, a filter material may be provided in the syringe adapter. In addition, or alternatively, a filling needle is provided which is removably mountable to the syringe adapter and may prevent bending or burring of the retractable needle.

Abstract: The invention relates to a kit for parenteral administration of drugs, particularly a kit for the infusion of those medicaments dissolved in solvents that extract toxic components from PVC, which is also suitable for the infusion of highly active medicaments, said kit ensuring a safe administration both for the patient and for healthcare staff.

Abstract: A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle.

Abstract: An apparatus includes a housing and a medicament container disposed within the housing. The medicament container includes a first plunger and a second plunger, each disposed therein. The medicament container has a first configuration and a second configuration. In the first configuration, the first plunger is disposed in a first position and the second plunger is disposed in a second position spaced apart from the first position by a first distance. Accordingly, a first portion is defined between the first plunger and the second plunger. A second portion is defined between the second plunger and a distal end of the medicament container. In the second configuration, the first plunger remains in the first position and the second plunger is disposed in a third position spaced apart from the first position by a second distance, such that a volume of the second portion is greater when the medicament container is in the second configuration than when in the first configuration.

Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments (1, 2) is disclosed where a primary delivery device (7) contains a first drug agent and accepts a medicated module (4) containing a single dose of a secondary premix medicament (2) containing the first drug agent and at least a second drug agent, where both the primary medicament (1) and the secondary premix medicament (2) are delivered through a single hollow needle (3, 16, 21, 31).

Abstract: Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.

Abstract: A pen injection device designed for use with dual or multi-chamber cartridges (14), is provided with an extended length plunger (24) having a non-drive portion (24?) on its forward end and the usual screw-threaded drive portion (24?) on its rearward end. This arrangement allows the plunger to be pushed forwardly whilst the dosing drive mechanism is disengaged to effect a reconstitution movement of the rearward bung (18?) in the cartridge. Thereafter the threaded portion on the plunger (24?) engages the drive mechanism to allow metered dosing.

Abstract: An intravascular port access device includes a first component having a chamber configured to attach reversibly to an intravenous line port. A second component reversibly attaches to the first component and contains a disinfecting agent and an applicator material. The second component is configured to be reversibly received over external surfaces of the intravenous line port. A method of cleansing an intravenous line port includes providing a port cleaning device having a first component includes a second cleaning agent. A third component has a microbiocidal agent and is reversibly attached to the first component. The second component is removed from the device, the external surfaces of the port are contacted with the second cleaning agent. the first cleaning agent is ejected from the chamber into the port, and the third component is used to cap the port.

Abstract: A cap assembly is disclosed for use with a lock solution delivery device. The cap assembly includes a housing defining a receptacle and having an inlet end and an outlet end. A plunger is movable axially within the receptacle from a retracted position to an advanced position and is rotatably supported within the receptacle from a first position to a second position. The plunger includes an axial extension configured to non-rotatably engage a syringe connected to the inlet end of the housing. The plunger is positioned to move from the first position to the second position in response to rotatable detachment of a syringe from the inlet end of the housing.

Abstract: Certain embodiments relate to a sprayer or other medical apparatus for applying a biocompatible coating in situ. Such an apparatus may have a first conduit connected to a first exit opening and a second conduit connected to a second exit opening to deliver a first composition through the first conduit and a second composition through the second conduit to mix the first composition and the second composition outside both the first conduit and the second conduit. The first composition may be, e.g., a precursor to a material formed after the mixing of the first composition and the second composition. The first exit opening and the second exit opening may be approximately adjacent to each other and define an angle that is less than about 140 degrees.

Abstract: An interface device is described which includes a body defining one or more cylindrical bores which are dimensioned to receive a standard luer lock syringe. Each bore includes a plunger movably positioned therein from a retracted position to an advanced position. The plunger and the distal end of the bore defines a first fluid reservoir and the standard syringe assembly defines a second fluid reservoir. The interface device and the syringe assembly are operable to sequentially deliver multiple fluids from the interface device to a catheter assembly.

Abstract: A syringe assembly is disclosed which includes a syringe body defining a first fluid reservoir and a fluid outlet. A plunger assembly includes a plunger rod and a plunger. The plunger is supported on a distal end of the plunger rod and defines a second fluid reservoir. The plunger is movable within the syringe body from a retracted position to an advanced position to eject fluid from the first fluid reservoir. A piercing member is supported on a distal end of the plunger rod within the second fluid reservoir. The piercing member is movable to pierce the plunger to eject fluid from the second fluid reservoir when a predetermined force is applied to the plunger in the advanced position.

Abstract: A multichamber ampoule with a locking and dispensing mechanism to store several substances and to dispense a mixture consisting of several substances, possessing a multiple-plug closure with several plugs to selectively close and open several outlet openings in the multichamber ampoule, and an adapter for mixing the substances and dispensing the mixture, wherein the multiple-plug closure and the adapter are connected to each other in an assembly designed to be removed from the multichamber ampoule.

Abstract: A novel method suitable for commercially mass production of hollow microneedle with high quality for delivery of drugs across or into biological tissue is provided. It typically includes the following processes: (1) coating an elongated template of a first material with a second material to form a cover; (2) removing tips of the template and cover to form an opening in the cover; and (3) removing the template of the first material to obtain hollow microneedles of the second material. This simple, efficient and cost-effective fabrication method can mass produce hollow microneedle arrays involving no complicated and expensive equipments or techniques, which can be used in commercial fabrication of hollow needles for delivering drugs or genes across or into skin or other tissue barriers with advantages of minimal damage, painless, long-term and continuous usages.

Abstract: A dispensing device which disperses medicate through a needle across a zone within a body with zero pressure differential. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a therapeutic agent reservoir in fluid communication with the needle, positioned within said housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the therapeutic agent reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with said reservoir-connecting conduit, and a linear drive attached to said needle or to said needle-receiving member.

Abstract: A seal-less, hand-held dispensing device for dispensing microliter quantities of a material at a site of a puncture wound having a predetermined dimension of not less than 0.8 mm comprises: a support platform; first and second hollow members on the platform; and a compatibly sized plunger disposed in each hollow member. The hollow members are positioned on the platform such that a circumscribing circle centered on a point between the hollow members has a diameter that is not greater than about 0.8 mm such that both of the hollow members are insertable into a site of a puncture wound without undue disruption of any tissue matter surrounding the site.

Abstract: Disclosed is a dispensing device comprises a dispense mechanism and a multicomponent syringe. The fastening parts of the syringe are embodied such that the syringe can be inserted into a holder on the dispense mechanism on the plane of the reservoirs thereof and perpendicular to the plane formed by the handle and the triggering lever of the dispense mechanism. The fastening parts on the syringe and the insertion opening on the syringe holder of the dispense mechanism are provided with coding elements that ensure that the syringe is inserted in only one direction, thus preventing non-certified syringes from being dispensed by the dispense mechanism. In a preferred embodiment, ergonomically shaped syringe flanges can optionally be used for dispensing the syringe in an optimal manner by hand with the aid of a dispense mechanism.

Abstract: A multiple component cartridge includes a barrel defining a chamber and a longitudinal axis. A first plunger is disposed within the chamber and in sealing engagement with the barrel. The first plunger includes at least one member and is movable relative to the barrel such that the at least one member is configured for movement relative to the first plunger to facilitate passage of at least a first component through the first plunger. A second plunger is disposed within the chamber and in sealing engagement with the barrel. The second plunger includes at least one member and is movable relative to the barrel such that the at least one member of the second plunger is configured for movement relative to the second plunger to facilitate passage of at least a second component through the second plunger.

Abstract: The invention includes a composition useful for preparing a tissue sealant for use on a patient, comprising: autologous fibrinogen, an activating agent and at least one supplement. The invention includes a method of treating a disc having at least one defect, comprising: introducing a composition into the disc, wherein the composition comprises autologous fibrinogen and an activating agent, and wherein the composition forms fibrin.

Abstract: The present invention relates to a medicament delivery device comprising a generally elongated housing comprising a proximal part (10) and a distal part (12); a medicament cartridge (18) comprising a proximal opening closed by a septum (30), an axially movable distal stopper (26), and a first enclosure (20) wherein a liquid and a gaseous fluid are enclosed; a medicament delivery member (36) attachable to said proximal part (10) and having a non-delivery end (34); a medicament cartridge holder (16) wherein the medicament cartridge is coaxially arranged, said cartridge holder being arranged coaxially movable inside said proximal part and comprising holding means (38, 40) capable of holding said medicament cartridge holder (16) in a non-activated position in which said cartridge holder is releasebly engaged to said proximal part and in which a predetermined distance is present between the septum and the non delivery end; a manual pressure mechanism arranged to be moved from a non-pressure position to a pressure

Abstract: A device for storing and administering active substances, including a plurality of reservoirs for respectively accommodating at least one active substance. The reservoirs are disposed in a radial manner with an end face facing the direction of the center of the device. A mechanism is mounted in the device to open and close the reservoirs. A needle-free injection device delivers at least one active substance to a user.

Abstract: A dispensing assembly comprises a syringe and at least one accessory, such as a mixer or a closure cap. The syringe defines a first fastening area with a first pair of retaining elements, and the accessory defines a second fastening area with a second pair of retaining elements. The accessory has a housing with two mutually opposite, compressible housing portions. These housing portions are offset in relation to the second pair of retaining elements along the circumference of the housing. The fastening areas are configured such that the accessory is capable to be slipped-on the syringe and removable therefrom without a twisting motion, by applying pressure to the compressible housing portions.

Abstract: Drug delivery devices adapted to receive liquid medication vials to fill a reservoir, utilize sliding through valves that are closed except when driven by force of liquid medication pushed by a plunger to an open position to feed the medication via needle to a patient or via a connection to an IV port. The devices have multiple seals and automatically close up when pressure on the plunger is released. The methodology is also included.

Abstract: A device (10,110,210) for the expression of liquids, such as for the maintenance treatment of vascular catheters. A syringe (16;116a,116b;216) has a support structure (15,215) and includes at least two separate compartments (11,12;111,112;211,212) in which liquids for treating the lumen (L,283) of a catheter (C,280) with which the device is associated. The syringe further includes a closure plug (13,213) to be associated with the lumen being treated, which is coupled, by virtue of a releasable securement arrangement, to support structure (15,215). At least one plunger (16;116a,116b;216) is also included for infusing, in preset order, the different treatment liquids into the lumen to be treated, and the syringe further includes a duct (17,217) which is in fluid communication with the two compartments and is arranged through a through hole through the closure plug (13,213) in order to allow access of the treatment liquid to the interior of the lumen (L,283) upon activation of the plunger.

Abstract: A dual-chambered drug delivery device (201) includes a first chamber (205) in which a medicament is stored. A dose setting member (213) is rotated to set a medicament dose. The dose setting member (213) being rotatable to set the medicament dose. The dose setting member (213) is not axially moveable. A second chamber (221) is in fluid communication with the first chamber (205). The medicament dose is transferred to the second chamber (221) from the first chamber (205) prior to injecting the medicament dose. A needle (203) communicates with the second chamber (221) to inject the medicament dose into an injection site.

Abstract: A dual-chambered drug delivery device (201) includes a cartridge (211) having a first chamber (212) for storing a medicament and a second chamber (211) in fluid communication with the first chamber (212). A dose setting member (241) is used to set a medicament dose to be injected at an injection site. A piston (281) is disposed in the second chamber (221). An upward stroke of the piston (281) draw a portion of the medicament dose into the second chamber (221) and a downward stroke of the piston (281) expels the portion of the medicament dose. A needle (205) communicates with the second chamber (221) for sequentially injecting the portions of the medicament dose into the injection site.

Abstract: A dual-chambered drug delivery device (301) includes a first chamber (342) in which medicament is stored and a second chamber (331) in fluid communication with the first chamber (342). A medicament dose is transferred to the second chamber (331) from the first chamber (342) prior to injecting the medicament dose. A needle (363) communicates with the second chamber (331) for injecting the medicament dose into an injection site.

Abstract: Described are novel medical delivery devices that can be used to effectively distribute a medical agent to multiple sites within a tissue volume without requiring the device to be repositioned, including for example to distribute the medical agent within the nucleus pulposus tissue of a spinal disc. Also described are medical delivery devices configured to simultaneously remove fluid from the tissue volume into which a medical agent is being delivered, thus avoiding or otherwise decreasing any pressure build-up and facilitating an effective, uniform delivery of the therapeutic agent.

Abstract: The subject invention relates to novel soluble forms of planar ring structured organic compounds including flavonoids, and their production. The invention also includes the use of these novel formulations of planar ring structured organic compounds in the preparation of formulations and products. The invention also relates to a wide variety of applications of the formulations of the invention. The subject invention includes novel soluble forms and various formulations of flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.

Abstract: A two-chambered, sequentially injectable syringe is disclosed. The syringe has two concentric barrels, substantially cylindrical in shape. The outer barrel has an open end adapted for receiving an inner barrel/first piston. The inner barrel/first piston contains a flushing liquid. The syringe has a second piston slidably movable in the inner barrel and a latching mechanism that can alternate between a locked configuration and an unlocked configuration. In the locked configuration, the latching mechanism prevents the second piston from substantially all longitudinal movement relative to the inner barrel. In the unlocked configuration, the latching mechanism permits longitudinal motion of the second piston within the inner barrel.

Abstract: A two-chambered, sequentially injectable syringe is disclosed. The syringe has two concentric barrels, substantially cylindrical in shape. The outer barrel has an open end adapted for receiving an inner barrel/first piston. The inner barrel/first piston contains a flushing liquid. The syringe has a second piston slidably movable in the inner barrel and a latching mechanism that can alternate between a locked configuration and an unlocked configuration. In the locked configuration, the latching mechanism prevents the second piston from substantially all longitudinal movement relative to the inner barrel. In the unlocked configuration, the latching mechanism permits longitudinal motion of the second piston within the inner barrel.

Abstract: The present invention relates to medicament delivery device comprising a generally tubular distal housing part (19); a generally tubular medicament container holder (16); a medicament container (18); a plunger rod (32); resilient force; an actuation means (34) comprising flexible locking means and an activation button; a release means (40); and a resilient means (60) characterized in that said plunger rod comprises a number of stop engagements (38) arranged on its outer circumferential surface and arranged to co-act with corresponding stop engagements (37) on the flexible locking means, such that when said activation button is proximally depressed said stop engagement (37) on said flexible locking means come out of contact from one stop engagement (38) of the plunger rod; and such that when said activation button (48) is released, said resilient means (60) forces the activation button and thereby the flexible locking means to move distally such that said stop engagements (37) on said flexible locking means co

Abstract: A device (10,110,210) for the expression of liquids, such as for the maintenance treatment of vascular catheters. A syringe (16; 116a,116b; 216) has a support structure (15,215) and includes at least two separate compartments (11,12; 111,112; 211,212) in which liquids for treating the lumen (L,283) of a catheter (C,280) with which the device is associated. The syringe further includes a closure plug (13,213) to be associated with the lumen being treated, which is coupled, by virtue of a releasable securement arrangement, to support structure (15,215). At least one plunger (16; 116a,116b; 216) is also included for infusing, in preset order, the different treatment liquids into the lumen to be treated, and the syringe further includes a duct (17,217) which is in fluid communication with the two compartments and is arranged through a through hole through the closure plug (13,213) in order to allow access of the treatment liquid to the interior of the lumen (L,283) upon activation of the plunger.

Abstract: A discharge device for discharging a product from a tube having a delivery outlet and a deformable wall. The discharge device according to the invention comprises a housing with a chamber that has a chamber opening and in which the tube is accommodated. A movable stopper is arranged inside the tube and is placed at the end opposite the delivery outlet and closes this end of the tube. An advancing member can be connected to the stopper and is displaceable inside the tube in the direction of the delivery outlet for discharging the fluid product from the tube.

Abstract: A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.

Abstract: An applicator assembly for mixing at least a first and a second component is provided. The applicator assembly includes a manifold configured for operable engagement with first and second source of component, the manifold including first and second component channels therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including first and second component lumens extending the length thereof, the first and second component channels in fluid communication with the first and second component lumens, a tip assembly defining a first chamber, an intermediate chamber and a final chamber, wherein the first chamber is configured to receive a distal end of the elongated shaft, the second chamber is configured to receive an insert, and the final chamber is configured to receive the first and second components prior to the mixture being ejected from an outlet defined in the distal end of the tip assembly.

Abstract: A unidirectional injector having at least one cylinder-piston unit, the piston thereof being displaceable between two stroke end positions relative to the cylinder, wherein the cylinder-piston unit comprises at least one sealing system sealing a compensating space from the surroundings. To this end the piston is provided at its front surface with an axial annular groove for accommodating a seal ring or a permanently elastic seal material, that the cylinder is provided with a first seal element and a second seal element which are spaced by at least a piston stroke, or that the piston is provided with the first seal element and the second seal element which are spaced by at least a piston stroke, or the cylinder carries the first seal element and the piston carries the second seal element which is displaced with respect to the first by the piston stroke.

Abstract: The invention provides a packaging and administering device for administering a hydro-alcoholic solution by passing through a mucous membrane, the device comprising a deformable container for receiving at least one first fraction of the solution, a base that is secured to the container, and an administering tube that is secured to the base and that is suitable for receiving at least one second fraction of the solution, and that includes a cap. The tube includes a chamber for containing the at least one second solution and that is defined by two membranes, and the cap is movable in translation between two extreme positions and includes a needle for coming to pierce the two membranes in one of the extreme positions.

Abstract: A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes an injection needle disposed within the housing for moving between a retracted position and an extended position.

Abstract: A device (10,110,210) for the expression of liquids, such as for the maintenance treatment of vascular catheters. A syringe (16; 116a,116b; 216) has a support structure (15,215) and includes at least two separate compartments (11,12; 111,112; 211,212) in which liquids for treating the lumen (L,283) of a catheter (C,280) with which the device is associated. The syringe further includes a closure plug (13,213) to be associated with the lumen being treated, which is coupled, by virtue of a releasable securement arrangement, to support structure (15,215). At least one plunger (16; 116a,116b; 216) is also included for infusing, in preset order, the different treatment liquids into the lumen to be treated, and the syringe further includes a duct (17,217) which is in fluid communication with the two compartments and is arranged through a through hole through the closure plug (13,213) in order to allow access of the treatment liquid to the interior of the lumen (L,283) upon activation of the plunger.

Abstract: A device (10,110,210) for the expression of liquids, such as for the maintenance treatment of vascular catheters. A syringe (16;116a,116b;216) has a support structure (15,215) and includes at least two separate compartments (11,12;111,112;211,212) in which liquids for treating the lumen (L,283) of a catheter (C,280) with which the device is associated. The syringe further includes a closure plug (13,213) to be associated with the lumen being treated, which is coupled, by virtue of a releasable securement arrangement, to support structure (15,215). At least one plunger (16;116a,116b;216) is also included for infusing, in preset order, the different treatment liquids into the lumen to be treated, and the syringe further includes a duct (17,217) which is in fluid communication with the two compartments and is arranged through a through hole through the closure plug (13,213) in order to allow access of the treatment liquid to the interior of the lumen (L,283) upon activation of the plunger.

Abstract: A liquid medication dispenser includes a housing that has open top and bottom. The housing includes a central channel and a plurality of internal compartments disposed around the central channel. Each internal compartment is configured to hold liquid medication. The central channel is provided with symmetrically disposed bottom apertures configured to open into respective internal compartments. A shaft is configured to rotate and advance within the central channel. The shaft has a bottom hollow portion and at least one lateral aperture thereon configured to align with each one of the bottom channel apertures. The lateral shaft aperture aligns with a respective bottom channel aperture to allow transfer of liquid medication under gravity from the corresponding internal compartment into the bottom hollow portion of the shaft. The bottom hollow portion is apertured at one end to allow for transferred liquid medication to drip out of the dispenser in a controlled fashion.

Abstract: Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.

Abstract: A flush syringe assembly comprises a barrel including a cylindrical side wall having an inside surface defining a chamber for retaining fluid, an open proximal end and a distal end including an elongate tip extending distally therefrom having a passageway in fluid communication with the chamber. A plunger including an elongate body portion has a stopper at its distal end. The stopper is slidably positioned in fluid-tight engagement with the inside surface of the barrel for driving fluid out of the chamber. The distal end of the stopper is configured to collapse while fluid is being driven though the passageway through motion of a plunger and to continue to drive fluid through the passageway after motion of the plunger has stopped.

Abstract: A combination of a valve assembly and multi-chamber, sequential delivery syringe is disclosed. The combination effectively provides a safety system for transferring hazardous materials from a vial to a site of use. All potentially hazardous materials are flushed from exposed connecting sites prior to disconnections.

Abstract: A method and apparatus for injecting fluid into areas having high density tissue that creates a high backpressure resistance on the injection device is disclosed. The high backpressure resistance is overcome through a mechanical advantage achieved by using a secondary reservoir having a cross-sectional area smaller than the cross-sectional area of a primary reservoir. Exemplary injection device reservoir housings may comprise a primary reservoir, a secondary reservoir, a check valve, a septum penetrating cannula, travel limits, a pen needle connecting portion, sliding seal guide ribs, a sliding seal, a pen needle assembly, a needle stop, and a patient needle.