Abstract: An injection device including an accommodating device for a substance to be delivered, e.g. a vial or ampoule holder, which is insertable into and can be displaced relative to the injection device or a part thereof; an adjusting element for adjusting a dose to be administered from the injection device, which element is inserted in the injection device; and a coupling element for coupling the accommodating device to the adjusting element so that the adjusting element is at least partially moved out from the injection device when the accommodating device is inserted. A method for preparing an injection device using a dual chamber vial or ampoule to administer a substance, wherein the method involves using an adjusting device which is released, extended or pushed out from the injection device not before or after the substance to be administered from dual chamber vial or ampoule is mixed.

Abstract: A syringe is disclosed.

Abstract: A device for applying a lock solution in a catheter or other access system comprises a syringe (302) having an expulsion arrangement (305, 311) for expelling the lock solution from the device, said expulsion arrangement including a plunger (305) arranged in a housing (304), further comprising a sterile connector (303) for connecting the syringe (302) to the catheter. The connector (303) is arranged to engage a tip (307) of the expulsion arrangement (305, 311) tightly when the syringe (302) is inserted in the connector (303). The connector (303) is arranged to prevent the tip (307) of the expulsion arrangement (305, 311) from entering the catheter. The tip (307) is frangible. A method of applying a lock solution in a catheter or other access system is also disclosed.

Abstract: A mixing syringe having a first sealed chamber containing a powder (powder housing) and a second sealed chamber containing a liquid (liquid housing). When the user needs to inject a patient, he or she holds the mixing syringe approximately upright and depresses a plunger. This motion causes a piercer to pierce a foil seal separating the two chambers. The liquid then drops down into the powder housing. The liquid flows through a passage in a piston located in the powder housing, where it then comes in contact with the powder itself. As the user continues pressing the plunger downward, the piercer comes to rest within the piston and seals the passage through the piston, thereby locking the piercer and piston together. The device is then ready for an injection. As the plunger is further depressed, the piston expels the powder and liquid mixture through a needle.

Abstract: A reciprocating syringe that can be used in connection with existing syringe barrels and fittings. Some embodiments comprise a frame, adapted to retain two existing syringe barrels. The frame can accommodate fittings on one or both barrels. The invention also provides a plunger complex, comprising two plungers, each adapted for use with one of the syringe barrels. The two plungers are coupled such that pushing of each plunger into its barrel causes the other plunger to pull outwards relative to its barrel. The two plungers can be coupled by a flexible line attached to one plunger, routed from the plunger out of the corresponding barrel into the other barrel, and attached to the other plunger. The invention contemplates various frame configurations to accommodate desired line and pulley performance characteristics. Other embodiments comprise a frame adapted to retain an existing syringe barrel, and an auxiliary actuator mounted with the frame.

Abstract: The present invention provides a pharmaceutical composition comprising a chemical compound or a herb extract or the combination having at least one of the activities of antiviral, antibacterial, antifungal, anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, for the treatment and prevention of a disease of a mammal. The present invention also provides a system for delivering the composition to the hard-to-reach sinuses of a mammal to reduce the load of the pathogen, to reduce the amount of inflammatory mediators, to heal pathological changes, and collectively to treat a disease of a mammal, such as allergic fungal rhinosinusitis. The invented method of treating a human disease reduces infectious and inflammatory agents without causing antibiotic resistance or adverse event.

Abstract: The present invention relates to a syringe for storage, mixing and dispensing of multi-component paste materials, and more precisely to a syringe for two or more components of a paste material which are to be mixed together. The syringe may be activated so that the chambers containing the components are opened, and the components may be mixed together and extruded through a mixing tip.

Abstract: Devices and methods for simultaneous injection or delivery of two or more substances from separate syringes. The syringes are loaded into a device that has a handle and a screw driven mechanism for simultaneously depressing the plungers of the syringes. The user grasps the handle and positions the device. Thereafter, the screw mechanism is used to simultaneously advance the plungers of the syringes thereby simultaneously expelling the substances from the syringes.

Abstract: Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.

Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.

Abstract: The dispensing appliance for a double syringe includes double plungers (4) connected by a thrust plate (5) and a flange holder (6) having a guiding slot (8) for receiving the retaining flange (9) of the double syringe (1) and at least one finger rest grip (7). Such a dispensing appliance allows an easier dispensing especially of smaller double syringes.

Abstract: A mixing syringe and method for using the mixing syringe are provided. The mixing syringe comprises a housing having a first compartment for containing a first component, an outer plunger having a second compartment for containing a second component, and an inner plunger. Prior to use, a seal separates the first and second components. To prepare the mixture, the seal is pierced and the two components are mixed. The mixing syringe and its method of use are particularly suited to applications in which at least one of the mixture components is a relatively highly viscous material.

Abstract: The invention relates to the use of an aqueous gel in the repair of or prevention of damage to soft tissue, the gel comprising an aqueous gel obtainable by polymerizing one or more olefinically unsaturated monomers comprising one or more phosphate, phosphonate, borate, sulphate and/or sulphonate groups. This is preferably used for intervertebral discs or a lens of an eye. Kits and syringes containing the components are also provided.

Abstract: A medical device including a catheter having a proximal end portion, a distal end portion, and a medial portion extending therebetween. The proximal end portion may have at least one evacuation lumen extending longitudinally therethrough, and at least one evacuation opening extending laterally therethrough and intersecting the evacuation lumen to permit evacuation of waste from a wound. The distal end portion may have at least one medicine dispensing lumen extending longitudinally therethrough and at least one medicine dispensing opening extending laterally therethrough and intersecting the medicine dispensing lumen to permit dispensing of medicine into the wound. The medial portion may have at least one medicine reservoir lumen therein connected in fluid communication with the medicine dispensing lumen of the distal end portion. Also, a barrier may longitudinally separate the evacuation lumen and the medicine reservoir lumen.

Abstract: A multi-chamber syringe 10 which can be manufactured at a low-cost and high-productivity is provided. The syringe 10 includes a generally cylindrical barrel 12, a push member 14 and a plug 16, both of which are disposed to fit the inner side surface 12a of the barrel 12 and slidably on the inner side surface 12a. The plug 16 has a main surface 16a provided with a projection 34 having a top 34a which is eccentric to the main surface 16a. When the push member 14 slides in the direction indicated by Arrow A, the plug 16 comes under pressure from the side on the open end 18. When the projection 34 of the projection 16 makes contact with the choked end 20, the pressure from the side on the open end 18 acts to turn the plug 16 in the direction indicated by Arrow B. This causes a bending deformation in a main body 30 and flanges 32a, 32b of the plug 16, to form a first gap 38 and a second gap 40 between the inner side surface 12a of the barrel 12 and the plug 16.

Abstract: A fluid dispensing device, particularly suited to medicine but also having many other applications. The device selectively dispenses any of one or more fluids contained within the device. Adapters on the dispensing end of the unit permit the device to be effectively used for intra-venous, intra-dermal or intra-muscular injections, gasses, colloids, gels, liquids or other fluids. Adapters on the head of the unit permit the device to be used with or without electrical power and to varying degrees of automatic control for timing, sequence, volume of fluid dispensed and other features.

Abstract: The present invention relates to a medicament delivery device comprising a generally tubular distal housing part (18); a generally tubular proximal housing part (12) releasibly connected to said distal housing part; a medicament container (70) having opposite proximal and distal ends and a slidable stopper, wherein the container is partially and slidably arranged within the proximal housing part; a plunger rod (72) having opposite proximal and distal ends and being arranged within said distal housing, wherein the proximal end of the plunger rod is abutting the stopper of the container; drive means arranged within said distal housing and being operably connected to said plunger rod for driving said plunger rod and thereby said stopper towards the proximal end of the device; characterised in that the device further comprises a priming device (34) having a distal end comprising tune engagement means (38) arranged to cooperate with corresponding tune engagement means (24) arranged at the proximal housing, an end

Abstract: The present invention relates to medicament delivery device comprising a generally tubular distal housing part (19); a generally tubular medicament container holder (16); a medicament container (18); a plunger rod (32); resilient force; an actuation means (34) comprising flexible locking means and an activation button; a release means (40); and a resilient means (60) characterised in that said plunger rod comprises a number of stop engagements (38) arranged on its outer circumferential surface and arranged to co-act with corresponding stop engagements (37) on the flexible locking means, such that when said activation button is proximally depressed said stop engagement (37) on said flexible locking means come out of contact from one stop engagement (38) of the plunger rod; and such that when said activation button (48) is released, said resilient means (60) forces the activation button and thereby the flexible locking means to move distally such that said stop engagements (37) on said flexible locking means co

Abstract: The invention relates generally to treatments of disordered bony structures, in particular to vertebroplasty compositions and methods and, more specifically, to treating vertebral bodies in living creatures, in particular, human beings and also compositions suitable for use in such methods and preparation and use of such compositions. According to the invention the composition to be used is an addition curable polysiloxane system.

Abstract: A split syringe includes two or more separate syringes held together to become one full cylindrically shaped syringe assembly. The needles of the separate syringes may be held together by a larger outside needle. For example, two half-cylindrically shaped syringes may be joined together to become one full cylindrically shaped syringe assembly.

Abstract: Improved fluid delivery devices and systems are disclosed, including drug delivery devices and systems, and methods that permit, inter alia, the rapid sequential delivery of two or more fluids to a single external fluid flow or intravenous line.

Abstract: A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

Abstract: A device for dispensing multiple components has a syringe housing comprising at least one storage container that is divided into at least two chambers and has a bypass arrangement, and a second storage container with or without a bypass arrangement, the syringe housing being realized as part of a double syringe or double cartridge having a double plunger and a common outlet. The bypass arrangement comprises at least two indentations. The device is simple to manufacture and provides for an improved mixing of components, in particular powder and a fluid, and improves dispensing under hygienic conditions.

Abstract: The invention relates to a method and device for treating or preventing or suppressing a disease or condition in a non-human animal. The method comprises the steps of providing a single delivery device containing two components for sequential delivery from the delivery device. A first component is delivered from the single delivery device into a teat canal of a non-human animal and subsequently the second component is delivered from the single delivery device into the teat canal. The components are delivered without substantial mixing of the components.

Abstract: The present disclosure relates to an apparatus and method for combining a solid particulate with a solvent prior to an injection protocol within an injector device. The solid particulate may be a pharmaceutical compound and the microcapsules contain a solvent for such particulate. Upon application of pressure, the microcapsules may be configured to burst and release the solvent, thereby dispersing and/or partially dissolving the particulate. The injector therefore allows for the use of relatively unstable pharmaceutically active compounds in a device that requires relatively long storage times and the use of pharmaceutical compounds that are relatively stable in the dry state.

Abstract: A medical instrument for suction and irrigation comprises an elongate shaft with a first channel serving as suction channel and with a second channel serving as irrigation channel, the shaft having a first tube which is closed in cross section and in which one of the channels is present. The shaft has a second tube which is open in cross section along its length and is placed with its open lengthwise side on an outside face of the first tube and secured sealingly thereon, the other channel being formed in the space between the outside face of the first tube and an inside face of the second tube. A method for production of the instrument is also described.

Abstract: The present invention provides an injection delivery system for the injection delivery of at least two fluid doses to a small bird by penetrating the skin of the recipient bird with at least one injection needle. The present injection delivery system comprises an injection needle device and a metering device. The injection needle device can either be a stationary unit or a hand held device.

Abstract: Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.

Abstract: A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.

Abstract: Embodiments of the invention relate to hyaluronidase as an adjuvant to increase the injection volume and dispersion of large diameter synthetic membrane vesicles containing one or more therapeutic agents. In particular, embodiments of the invention relate to compositions comprising hyaluronidase and large diameter synthetic membrane vesicles containing a therapeutic agent, and methods of administration of the same. Methods of making large diameter synthetic membrane vesicles containing an active pharmaceutical ingredient and their use in combination with hyaluronidase as medicaments are provided.

Abstract: A device for pre-treating and injecting a liquid specimen includes a first syringe including an open top first tube including a first hole in the bottom and protrusions, a second syringe including an open top second tube including a second hole in the bottom and an inner diameter greater than an outer diameter of the first tube, a second piston movable along an inner wall of the second tube and including a third hole and a communication channel providing fluid communication between the first hole and the third hole, and a joint portion attachable to and detachable from a top of the second tube and including an opening corresponding to a transverse cross-section of the first tube and grooves corresponding to the shape of the protrusions such that the first tube passes through the joint portion when the protrusions are matched with the grooves.

Abstract: An applicator device 6 is provided to mix and apply two or more compositions of adhesive or sealant to tissue or bone. The applicator device generally includes an applicator assembly having a handle containing a double-barreled syringe, removably mounted thereto, and a regulator assembly for providing control and sources of air pressure to the applicator assembly.

Abstract: Atomizers (1) comprising a cartridge holder (4) which is arranged in the housing (3), a mouthpiece (5) which is provided on the housing (3) and in which an atomization device (6) is arranged, and a connecting tube system (7) which connects the atomization device (6) and the cartridge holder (4), wherein the atomization device (6) has at least one nozzle body (8) and the connecting tube system (7) has at least one passage (9) with a hollow plunger (10) mounted displaceably therein, wherein the hollow plunger (10) includes a valve body (21). In accordance with a first embodiment the atomizer (1) has a first hollow plunger (10a) mounted displaceably in a first passage (9a) and a second hollow plunger (10b) mounted displaceably in a second passage (9b), wherein the first hollow plunger (10a) and the second hollow plunger (10b) extend into the cartridge holder (4).

Abstract: An injection device for use with a two-chamber ampoule, wherein the device includes a front casing part with which the two-chamber ampoule can be associated, a rear casing part, a threaded drive accommodated by the rear casing part, a piston rod which, during a blending movement, is moved by the threaded drive toward a dispensing end of the device and slaves at least a closing piston of the two-chamber ampoule in the process, wherein a spring element presses the piston rod toward the dispensing end during a delivery movement.

Abstract: The present invention provides for the transplantation of tissue from a donor site in a body to a recipient site. The device includes an outer chamber having an interior volume in which a perforated inner chamber can be placed. During the aspiration of tissue, a vacuum is formed in the interior volume of the outer chamber, to draw tissue from a cannula into the perforated inner chamber. The perforations are sized such that fat is collected within the inner chamber, while fluids and other materials are drawn through the perforations, away from the collected fat. For reinjection, the inner chamber can be removed from the outer chamber, and a sleeve positioned to cover the perforations and thereby form a syringe body that can be interconnected to a needle and plunger for reinjection of the collected fat.

Abstract: A pipetting device including a pipetting unit (12) having an application chamber (26) and a first end (16) that is realized with a discharge opening (18), and a second, open end (20). In the vicinity of the second, open end (20) of the pipetting unit (12), a sleeve-like receptacle unit (14) is guided so that it can move axially on at least two sealing lips (22, 24) that project radially inward and are at some distance from each other, which is provided on the side facing the application chamber (26) of the pipetting unit (12) with a base element (28), and on the side facing away from the application chamber (26) has an opening (32) and which has, in the vicinity of its periphery, at least one opening (34), the axial dimensions of which are somewhat smaller than or equal to the distance between the sealing lips (22, 24).

Abstract: A system in accordance with embodiments of the present invention includes a cannula interconnected to a washing reservoir by a flexible conduit. The washing reservoir has an outlet that is connected to the inlet of a tissue collection reservoir. Washed tissue can be removed from the washing reservoir by tipping or otherwise causing the outlet of the washing reservoir to be covered by washed tissue. Tissue collected in the tissue collection reservoir can be readied for injection into a body by removing an inner or filter chamber from an outer chamber and blocking holes in the body of the inner chamber to use the inner chamber as part of a syringe.

Abstract: A discharge assembly is disclosed which partitions a conventional syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing syringe apparatus. Incorporated in the discharge assembly is a syringe stopper body and an associated valve stem which in combination form a valve. A syringe plunger communicates through fluid in the proximal chamber to force displacement of the discharge assembly. The valve is actuated by collision between a rigid member which is a part of the valve stem and the distal internal surface of the syringe. The discharge assembly may be made from two parts: (1) the stopper body (made from conventional syringe stopper material); (2) the valve (actuating) stem made from rigid material similar to material from which the syringe barrel is made.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: A fluid dispensing device, particularly suited to medicine but also having many other applications. The device selectively dispenses any of one or more fluids contained within the device. Adapters on the dispensing end of the unit permit the device to be effectively used for intra-venous, intra-dermal or intramuscular injections, gasses, colloids, gels, liquids or other fluids. Adapters on the head of the unit permit the device to be used with or without electrical power and to varying degrees of automatic control for timing, sequence, volume of fluid dispensed and other features. A preferred embodiment utilizes a pre-formatted, disposable or re-useable cartridge of several drugs suited for a particular medical purpose.

Abstract: The present invention relates to an apparatus for providing specifically metered doses of at least two flowable dental materials in desired ratios to one another. In particular, the present invention allows for controlled metering and dispensing of two or more flowable dental substances which when subsequently mixed form a dental bonding composition, dental adhesive, dental cement, or other dental restorative or preparative materials. Specifically, one embodiment of the present invention utilizes a multi-rack system as well as a drive spring action to provide a substantial mechanical advantage to the user such that a relatively long throw of the dispensing button creates a relatively short, metered distance of movement of the multiple racks and corresponding pistons in the each lumen of a cartridge containing the component of the desired dental composition, allowing for small, metered doses of each flowable dental component to be dispensed from the apparatus in the proper proportions.

Abstract: An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition to a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.

Abstract: A device (10,110,210) for the expression of liquids, such as for the maintenance treatment of vascular catheters. A syringe (16; 116a,116b; 216) has a support structure (15,215) and includes at least two separate compartments (11,12; 111,112; 211,212) in which liquids for treating the lumen (L,283) of a catheter (C,280) with which the device is associated. The syringe further includes a closure plug (13,213) to be associated with the lumen being treated, which is coupled, by virtue of a releasable securement arrangement, to support structure (15,215). At least one plunger (16; 116a,116b; 216) is also included for infusing, in preset order, the different treatment liquids into the lumen to be treated, and the syringe further includes a duct (17,217) which is in fluid communication with the two compartments and is arranged through a through hole through the closure plug (13,213) in order to allow access of the treatment liquid to the interior of the lumen (L,283) upon activation of the plunger.

Abstract: The present invention concerns a device for metering products intended to be applied to the skin, in particular pharmaceutical or cosmetic compositions. The invention relates more particularly to a device taking the form of an applicator stick, the graduations of which allow users to determine precisely the quantity of medication to be applied to the skin as a function of the surface area to be treated.

Abstract: Implantable drug delivery apparatuses and methods are described. An input port septum receives a therapeutic drug. An implantable delivery catheter holds a volume of the therapeutic drug and includes a proximal end in fluid communication with the input port septum, a distal end including an output septum for removing fluid from the catheter, and a drug permeable surface for diffusion of the therapeutic drug into nearby tissue.

Abstract: This distribution device comprises a syringe body (30), a distributor (32), a feed tube (56) for a first active medical fluid opening into the syringe body (30), a tube (60) for the injection of this active fluid connected to a distal extremity (46) of the syringe body (30), a pressurized tube (64) designed to be connected to a patient through a pressurized line (12) and a tube (66) for the measurement of venous or arterial pressure. The pressurized, injection and measurement tubes open into a chamber (62) bounded within the body (32B) of the distributor (32). The device (2) comprises a flush tube (68) which is at least partly bounded by the body (32B) of the distributor (32), which opens into the chamber (62) and is fitted with a valve (70, 80) which can be operated manually.

Abstract: A method of making zeolite microneedles includes providing a polymer microneedles template, depositing zeolite seeds on the polymer microneedles template, and growing the zeolite seeds into an array of zeolite microneedles.

Abstract: A pre-filled syringe including a barrel 1, a base end gasket 4 which is fluid-tightly slidable in the barrel 1, a front end gasket 8 which is fluid-tightly slidable in the barrel 1, and a nozzle part 2 provided in a front end of the barrel 1, wherein the nozzle part 2 includes a front end gasket accommodation part 23 which is capable of accommodating the front end gasket 8, and liquid flow passages 21 extending in an axial direction in an inner periphery wall, through which a liquid medicine can pass when the front end gasket 23 is accommodated in the front end gasket accommodation part 23, and a sectional area of a front end of the liquid flow passages 21 is smaller than a sectional area of a base end.

Abstract: Dispenser (1) for adhesive Newtonian fluid, comprising: a syringe (5) containing the adhesive fluid; a plunger (23) for pushing the adhesive fluid out of the outlet spout of the syringe (5); an inlet (27) for a propellant gas; means (28) for mixing the adhesive fluid coming out from the syringe (5) and the propellant gas coming from said inlet (27) in order to obtain a mixture deliverable by atomization on a surface, said means (28) for mixing being shaped in such a way that the mixing of the adhesive fluid and the propellant gas takes place in proximity to an open end (14a) of a cannula or catheter (14) of the dispenser (1).

Abstract: A dosage delivery device having a housing within which is formed a reservoir, with a plunger located within the reservoir and movable to dispense a material from a discharge opening of the reservoir. The device includes a plunger actuation mechanism, which is movable between a contracted storage position, in which the mechanism is held, at least partially, within the housing and an extended primed position, in which the plunger can be actuated. The dosage delivery device additionally includes a priming mechanism slidably mounted with respect to the housing and movable between a storage and primed position to expose the discharge opening and release the plunger actuation mechanism.