Abstract: An on-body injector includes a drug reservoir having an outlet. First and second pistons may be positioned within the reservoir, with the second piston first being moved to open the outlet, followed by the first piston being moved to convey a drug from the reservoir via the outlet. The reservoir may instead include a cover, with a valve positioned between the outlet and the cover. The valve is rotated to place a channel of the valve in fluid communication with a through-hole of the cover, allowing flow from the reservoir via the outlet. The reservoir may instead include a valve movable from a condition in which it deforms the outlet, preventing flow through the outlet, to a condition allowing flow. The reservoir may instead include a seal that is deformed by an increase in pressure within the reservoir, with the deformed seal being open to allow flow through the outlet.

Abstract: Provided is an electrophoresis device that, by electrophoresis, feeds a sample into capillaries and optically detects the sample, the electrophoresis device being provided with capillaries, a capillary head provided at the distal end of the capillaries, a phoretic medium-filled container used for electrophoresis and filled with a phoretic medium, a guide member that covers the side surface of the phoretic medium-filled container, a seal member that seals from below the phoretic medium filled in the phoretic medium-filled container, and a plunger that presses the seal member.

Abstract: A vial adaptor comprises first and second housings coupled to each other, a sheath enclosing the first and second housings, and a spike disposed in the first and second housings. The first and second housings form a first chamber therein. The sheath and the first and second housings form therebetween a second chamber in air communication with the first chamber. The second housing is slidable relative to the first housing to cause the spike piercing through a front stopper to establish air and fluid communication with a vial attached to the vial adaptor, meanwhile to vary the volume of the first chamber and press the air into the second chamber. Upon a fluid being drawn from the vial, the air in the first and second chambers enters the vial to compensate the pressure reduction caused by the fluid drawn out to prevent fluid spillage or aerosolizing from the vial.

Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Abstract: A catheter assembly includes a catheter hub having an elastomeric septum that divides the catheter hub into a distal chamber and a proximal chamber. The septum also includes at least one slit that is closed and sealed when the septum is in an at-rest state. A septum activator is proximal the septum. When an external force pushes the activator against the septum, the activator deforms the septum so as to break the seal and create a flow path through the septum. A portion of the septum activator can be collapsible when subjected to the outside force. When the outside force is removed, the collapsible portion springs back to its at-rest shape, helping to pull the activator out of deforming engagement with the septum so that the septum can reseal. The activator can also be spring-biased away from engagement with the septum so that when the outside force is removed, the spring urges the activator out of engagement with the septum. With the activator removed, the septum slit can reseal.

Abstract: A percutaneous medication device, comprising a syringe to be filled with medical liquid and a needle formation attached to a leading-end of the syringe is provided. The needle formation comprises a needle formation body, from the surface of which a needle projects and a cover portion covers a leading-end of the needle formation body. The needle is inserted into a through-hole formed at the leading-end of the needle formation body and fixed by a fixation member. The needle formation body is mated to the cover portion, a space is formed between an inner surface of the cover portion and the leading-end of the needle formation body, and the needle projects from the leading-end surface of the cover portion through a needle insertion hole formed at the leading-end of the cover portion.

Abstract: Syringe assemblies are described with at least two co-axially positioned cylinders that move relative to one another by action of a spring. Aspects of the syringe assemblies include a protective unit in which a first cylinder of a first length is attached to a second cylinder of shorter second length. In different embodiments, a protective unit is formed of a single or singularly fabricated cylinder. The different protective units may be used with a syringe in which action of a plunger to push a plunger tip into contact with a distal wall of the syringe cylinder to discharge fluid located inside the syringe but does not immediately release the protective unit relative to the syringe cylinder to shield a needle.

Abstract: A syringe is provided with an inner tube which has at the tip thereof a mouth section through which liquid can enter and exit the inner tube; a bag body which is disposed inside the inner tube and is flexible and reversible; a gasket which is mounted to the tip of the inner tube; and an outer tube in which the inner tube is inserted together with the gasket so as to be movable in the axial direction. The syringe is configured in such a manner that, when liquid enters and exits through the mouth section, the bag body is reversed to change the volume of a containing space surrounded by the inner tube and the bag body.

Abstract: A needle and receiver assembly for use with a syringe cartridge filled with medicine includes a cartridge receiver having a hollow interior, an open end sized for receiving at least part of the syringe cartridge, and a closed end opposite the open end. The assembly includes a needle mounted on the receiver having a fluid passage extending between a sharp delivery tip at a distal end of the needle and a sharp access tip at a proximal end of the needle opposite the delivery tip positioned inside the hollow interior of the receiver. The assembly includes a cutter movably mounted in the hollow interior of the receiver for cutting the diaphragm of the cartridge when received in the hollow interior of the receiver.

Abstract: Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.

Abstract: A carpule and its method of manufacture, the carpule tubular body composed of a polypropylene or similar polymer, the tubular body being sealed at one end by a seal of a thermoplastic vulcanizate (TPV) or similar polymer, the seal having been injection molded in contact with the tubular body prior to full curing of the material composing the tubular body, such that a chemical fusion bond is created between the seal and the tubular body.

Abstract: A valved sheath introducer for venous cannulation, including a valve, sheath, handle and cap. The valve is configured to permit safe introduction and removal of medical instruments through the sheath introducer. The valve may have one or more anchoring members and a thickened central portion through which a slit is formed. The central portion may have one or more concave surfaces and the slit can be angled with respect to the top surface of the valve. The cap is attached to the handle, compressing a portion of the valve therebetween.

Abstract: A needle assisted jet injector and method for jet injecting medicament are disclosed. In one embodiment of the injector, the needle is retractably located within an injector nozzle assembly. Upon activation of the force generating source, a portion of the needle extends past the nozzle assembly and penetrates the outer layer of skin to deliver the medicament via jet injection to a deeper region. After activation, the needle retracts back into the nozzle assembly. In another embodiment, the needle is fixed to the end of the nozzle assembly. In both embodiments, the length of the portion of the needle that penetrates the skin is less than 5 mm.

Abstract: The withdrawal spike comprises a piercing thorn (10) and a housing (12) having filter chambers for air and fluid. In a connecting piece (23) for connection of an external device a self-closing valve (31) is arranged. Said valve (31) is adapted to prevent fluid from unintentionally flowing out of the withdrawal spike.

Abstract: A closed system, needleless valve device includes a generally tubular body defining an internal cavity. On the proximal end of the body there is an opening which is preferably sufficiently large to receive an ANSI standard tip of a medical implement. The distal end of the body has a generally tubular skirt. The valve also includes a hollow spike having a closed tip. The spike includes at least one longitudinal 18-gauge hole located distal the tip, and is seated inside the cavity such that the tip is below the proximal end of the body. An annular support cuff is connected to the spike which seals off a portion of the cavity of the body such that an upper cavity containing the tip is defined. The valve also includes a plastic, resilient silicone seal which fills the upper cavity and opening and covers the tip of the spike so as to present a flush surface. An adaptor enables the valve to be attached to a resealable container.

Abstract: A device and method for providing a suspended agent such as a contrast agent without mechanical resuspension. A volume of agent is divided into sub-volumes in a network of tubes, cells, sponges, grooves, etc. A propellant fluid flows through the network to release the suspended agent. The network may be internal to a container for the propellant fluid. Alternatively, the network may be adjacent an exit port of a container for the propellant fluid, or may be in-line between a propellant fluid container and a patient. The invention reduces sedimentation of agents into one or a few aggregates and eliminates a mechanical mixing step. The invention thus provides a uniformly suspended agent, improving patient health and safety and increasing cost and time savings.

Abstract: A device for collecting a blood sample from a plastic segment tube into a receptacle uses a cylindrical housing containing a hollow needle to puncture the segment tube as it is inserted into the upper port of the device. A series of ribs with medial edges are arranged in a radial pattern around the needle within the upper port to guide and support the segment tube as it is inserted. The ribs are separated by slots that also guide the sealed end of the segment tube. An annular recess around the lower port of the device holds the rim of the receptacle and allows blood released by the punctured segment tube to drain into the receptacle. The annular recess accommodates a wide range of test tube diameters, and exerts only a downward force on the rim of the receptacle when a segment tube is inserted into the upper port of the device.

Abstract: A dilation catheter for use in performing angioplasty procedures. The catheter includes a relatively long catheter shaft which has two lumens. A relatively short guidewire receiving tube is thermally bonded to the distal end of the shaft, with its lumen approximately aligned with one of the lumens of the catheter shaft and a stiffening wire positioned therein. A dilation balloon, preformed with a shape that enables it to be used in an offset configuration, is thermally bonded to the distal and proximal ends of the tube, with its lumen aligned with the remaining lumen of the catheter shaft. The balloon and tube together define channels for the perfusion of blood past the balloon, which channels remain open even when the balloon bears against the tube during the inflation thereof.

Abstract: This is a surgical device. In particular, it is a guidewire having a metallic core and specifically having a distal section comprising a number of fibers. The fibered distal tip is shapeable using, e.g., steam or hot air, and causes much less trauma than would a coil of similar capabilities.

Abstract: The invention relates to a catheter comprising a tube-like basic body with a proximal and a distal end and an expandable balloon member arranged close to the distal end to the basic body. The balloon member comprises a number of relatively stiff sections extending on a small diameter in a longitudinal direction of the basic body and relatively pliable sections extending inbetween, wherein the relatively pliable sections form lobes in an expanded state of the balloon member. The invention furthermore relates to a method for manufacturing a catheter according to the invention, wherein a piece of tube-like basic material is provided and, by blow molding, a balloon member is made in a mold, which is arranged to the bias material. The balloon member is manufactured in the mold cavity of a mold, the cross-section of which is lobated, by receiving a tube-like partial manufacture inside it and deforming it by blow molding into a shape corresponding to that of the shape of the mold cavity.

Abstract: A camouflaged injection needle is disclosed including a shaft, a flexible ellipsoid tip at one end of the shaft and a sharp needle tip positioned within the flexible tip and axially aligned with the shaft. The sharp needle tip is capable of piercing through the flexible tip and into an outer human tissue when the flexible tip is positioned on the outer human tissue and the shaft is urged in the direction of the outer human tissue. The injection needle is camouflaged to resemble a cotton swab. This reduces pre-injection anxiety of the patient.

Abstract: A device for collecting a blood sample from a plastic segment tube into a receptacle uses a cylindrical housing containing a hollow needle to puncture the segment tube as it is inserted into the upper port of the device. A series of ribs with tapered medial edges are arranged in a radial pattern around the needle within the upper port to guide and support the segment tube as it is inserted. The ribs are separated by slots that also guide the sealed end of the segment tube. An annular recess around the lower port of the device holds the rim of the receptacle and allows blood released by the punctured segment tube to drain into the receptacle. The annular recess accommodates a wide range of test tube diameters, and exerts only a downward force on the rim of the receptacle when a segment tube is inserted into the upper port of the device.

Abstract: A syringe containing drug to be injected, the syringe includes an injection tube, a needle mounted at the front end of the injection tube, a rubber sealing jacket stopper jacketing on the peak of the needle and an injection tube core movably and hermetically put inside the injection tube, which is characterized in that the injection tube core consists of an ampule of cylindrical bottle shape and a piston, the back end of the ampule is closed and at its front end there are a flange and a neck portion, the central through hole of the flange and the neck portion is interpenetrated with the inner cavity of the bottle-shaped injection tube core; the outside top of the piston appears as a cone, and its outside lower part is a cylinder matching the inner wall of the injection tube, while the inside top of the piston appears as an inner cone, and the form of its inside lower part matches the shapes of the flange and the neck portion located at the front end of the ampule; at the cone-shaped top of the piston there is

Abstract: The invention relates to a pre-filled injection device, comprising (i) a barrel which is open at each end in which, before using the device, a liquid diazepam formulation is accommodated in a sealed manner and which comprises at least one rubber sealing member to seal the said formulation, and (ii) an injection needle or a needle connection at the front end of the barrel, said sealing member being manufactured at least substantially from bromobutyl rubber.

Abstract: A self-sealing valve device for an angiographic catheter includes a housing having a first end adapted to form a luer lock connection with the proximal end of the angiographic catheter. A central bore extends between the first end of the housing and an opposing second end, and a deformable elastomeric slit seal is supported across the central bore to selectively seal the proximal end of the catheter. The slit seal is adapted to permit a guidewire to be passed therethrough and advanced into the catheter while sealingly engaging the walls of the guidewire to prevent blood loss through the catheter. The second end of the housing is provided with a female luer lock connection fitting for receiving the conical tip of a syringe, stopcock, or the like, and forming a pressure-tight connection therebetween.

Abstract: The invention relates to a flexible sealing member for an injection device, comprising a neck which encloses a channel which is open at one end and is closed at the other end by a diaphragm and has an annular flange at its closed end for a clamping connection of the sealing member in the injection device. The diaphragm is at least substantially in the shape of a spherical cap, its convex outer surface being remote from the open end of the channel in the neck. The invention further relates to an injection device comprising this sealing member.

Abstract: A medical device which presents the backflow of fluid therethrough is particularly useful as a bloodless catheter assembly, that is, prevents the backflow of blood through the catheter by utilization of a self-closing valve carried in a hollow catheter housing to one end of which a catheter is fixed so as to provide a fluid passage through the catheter and catheter housing. The fluid passage in the catheter housing is sealed by a self-sealing valve element extending transversely across the passage upstream from the catheter. A hollow needle is held in the catheter housing downstream of and pointed at the valve element. Attachment of a fluid dispensing medical appliance to the other catheter housing end forces the valve element downstream onto the needle so as to pierce the valve element and open a fluid passage from the catheter housing upstream of the valve element through the hollow needle to the catheter.

Abstract: A catheter with a double membrane gasket and a locking needle guard is disclosed. The gasket prevents blood from seeping through the catheter hub. The locking needle guard prevents the user from inadvertent needle sticks.

Abstract: A placement device for a catheter and guide wire comprising, a valve assembly having a proximal end, a distal end for connection to the catheter, an elastic valve member having a least one slit and a slide member being slidably received in the valve assembly and being movable between a first position spaced from the valve member with the valve member being closed, and a second position engaged against the valve member with the valve member being open, with the slide member having a bore extending therethrough. The device has a valve opener having an elongated stem on an end of the opener with an outer diameter sufficiently small to be received in the bore of the slide member, with the stem having sufficient length to extend through the slide member and open the valve member with the valve opener extending through the valve member, and with the stem having a channel with an inner diameter sufficiently large to receive the guide wire.

Abstract: A device for single usage for sampling liquids consisting of a hollow mounting tube closed at one end by a base which has a needle mount and into which can be slid a sampling tube. The sampling tube has a cap which has a diameter in the section of the cap projecting from the tube greater than the diameter of the tube to thereby form a shoulder. The mounting tube consists of a head into which the cap of the sampling tube slides, a body to guide the sampling tube, and internally projecting studs to retain the cap in the mounting tube. A breaking point is formed where the head and body join which must be broken in order to withdraw the sampling tube from the mounting tube after a sample has been taken.

Abstract: This invention relates to an injector with a cartridge for a liquid medicine, which is suitable as a throwaway type or a re-use type, and especially displays remarkable effects at urgent occasions. This injector substantially comprises an injector tube housing a cartridge into a body thereof and a cylinder slidably supporting a piston such that it is not removed therefrom at its end portion and in the injector tube by its front half part. Further, the cartridge is equipped with a concave on its bottom and the piston is equipped with a convex on its head for engaging means. The needle portion comprises an injecting needle and a hollow needle inwardly extending from the needle. If the needle portion is urged while it is fitted to the injector tube, the hollow needle pierces the cartridge and reaches the liquid medicine in the cartridge. The cylinder is defined with a stopper at its circumferential edge to restrain the piston with respect to the cylinder.

Abstract: The slidable piston closing the upper end of cartridge ampoules of the type used in hypodermic syringes is provided with a deformable section which, on forward and backward flexing, generates self-aspiration in the ampoule.

Abstract: A molded collapsible solution container, which is made from a tubular, plastic parison, defines a body portion having an integral neck portion and shoulder portion at one end thereof. The container is sealed at its opposite end. The body portion defines, in as-molded configuration, a generally oval cross-section taken perpendicular to the axis of the container, adjacent the neck and shoulder portion. The cross-section tapers progressively to a flat configuration at the end of the container opposite to the neck and shoulder portion, which facilitates a uniform manner of flat collapsing of the container progressively from the opposite end toward the end adjacent the neck and shoulder portion as the contents thereof are withdrawn through the neck portion, when the container is disposed in neck downward position.