Abstract: A disposable cartridge for a drug delivery device includes a flexible bag to accommodate a liquid medicament and having an opening adjacent to a sidewall, a socket having a fluid channel in fluid communication with a cartridge fluid coupling, and a housing covering at least a portion of the flexible bag and having a receptacle to receive the socket with the flexible bag. The socket extends into the opening of the flexible bag. The flexible bag's sidewall is fixed between the socket and the receptacle.

Abstract: A plungerless aspiration and/or injection device and a method of using the same are disclosed herein. The plungerless aspiration and/or injection device includes a housing; a needle portion disposed in the housing, the needle portion configured to be selectively retracted and extended by a user, the needle potion comprising a needle tip configured to be inserted into tissue of a patient for aspiration, injection, and/or implantation; and a bulb portion disposed in the housing, the bulb portion defining a fluid containing cavity that is fluidly coupled to the needle portion, and the bulb portion being elastically deformable so that the user is able to perform the aspiration, the injection, and/or the implantation on the patient by manipulating the bulb portion.

Abstract: Components for use in hollow organ irrigation systems are provided, including collapsible and expandable liquid reservoirs, self-supporting liquid containers for liquid reservoirs, and retaining elements for rectal catheters, which may be inflatable or un-inflatable.

Abstract: Disposable ampoule for use in an aerosol generating device, comprising: a medicament container that contains a medicament and is formed of a container body and a container bottom, and a predetermined break point that at least partly surrounds the container bottom, characterised by a collar that surrounds the predetermined break point at its outside and extends the container body over and beyond the container bottom.

Abstract: A micro-needle device for delivering a dental local anesthetic that includes a micro-needle array and a hollow spheroid shaped container. The micro-needle array has a base and two or more elongate micro-needles. The elongate micro-needles have an interior surface defining an opening through the elongate micro-needle and the base has a first major surface and a second major surface through which the opening of the elongate micro-needle passes to provide a passage across the base. The hollow spheroid shaped container includes an inside surface, where the first major surface of the base and the inside surface of the hollow spheroid shaped container define a volume that is in fluid connection with each opening of the two or more of the elongate micro-needle. This allows the dental local anesthetic to flow from the volume of the micro-needle device through the opening of the two or more of the elongate micro-needle.

Abstract: Disclosed therein is a sampler. The sampler includes: a chamber accommodating a fluid or solid reagent therein and being sealed at both ends with penetrable films; a tube joined with the chamber at one side, the tube having a hollow portion therein; and a movable bar having a tip which is formed at one end and has a specimen extracting portion, the tip being guided and moved through a hollow portion, the tip being adapted for mixing the specimen extracted by the specimen extracting portion with the reagent so as to form a diluted solution while penetrating through one end of the chamber and adapted for quantitatively discharging out the diluted solution while penetrating through the other end of the chamber.

Abstract: The invention relates to a method and device for treating or preventing or suppressing a disease or condition in a non-human animal. The method comprises the steps of providing a single delivery device containing two components for sequential delivery from the delivery device. A first component is delivered from the single delivery device into a teat canal of a non-human animal and subsequently the second component is delivered from the single delivery device into the teat canal. The components are delivered without substantial mixing of the components.

Abstract: A sampling device for vaginal specimens is revealed. The sampling device for vaginal specimens includes a tubular unit whose one end is disposed with a sampling unit, and at least one hole arranged on side walls of the same end of the tubular unit. The other end of the tubular unit is disposed with a saclike body or is inserted with an injection unit so as to send solution through the tubular unit to the hole for flushing vagina. By the sampling unit, a flushed vaginal specimen is collected. Thus the collection procedures of the specimen are easy and convenient to be performed and users have no uncomfortable feelings due to the lubricant solution.

Abstract: A dispensing device and the method of making same for dispensing medicaments to a patient that includes a housing, a first assembly connected to the first end of the housing that includes a body portion, and a penetrating sub-assembly. The first assembly also includes a rate control chip of novel construction that is connected to the penetrating sub-assembly and functions to control the rate of flow of medicinal fluid to the patient. Disposed within the housing is a second assembly that includes a shuttle, a collapsible container carried by the shuttle and a plurality of variable force springs that function to thrust the collapsible container into penetrating engagement with the penetrating member of the penetrating assembly and then to collapse the collapsible container to deliver the medicinal fluid to the patient. Connected to the second end of the housing is a novel third assembly that includes an operating member that functions to controllably move the shuttle forwardly of the housing.

Abstract: A needle and receiver assembly for use with a syringe cartridge filled with medicine includes a cartridge receiver having a hollow interior, an open end sized for receiving at least part of the syringe cartridge, and a closed end opposite the open end. The assembly includes a needle mounted on the receiver having a fluid passage extending between a sharp delivery tip at a distal end of the needle and a sharp access tip at a proximal end of the needle opposite the delivery tip positioned inside the hollow interior of the receiver. The assembly includes a cutter movably mounted in the hollow interior of the receiver for movement relative to the receiver and the needle to cut the diaphragm of the cartridge when received in the hollow interior of the receiver.

Abstract: A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

Abstract: Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.

Abstract: The present invention is directed to providing a sterile package (1, 1?) integrally housing a contents-pouring device (5, 5?) which has improved contents pourability and tamper evidence. According to the present invention, the sterile package (1, 1?) can be efficiently produced by adopting the following steps of: (1) disposing a parison (27) in a mold (32) for a plastic container main body, (2) blowing sterile air from a nozzle (24) inserted in the parison (27) to blow-mold the plastic container main body, (3) filling the plastic container main body (2) with contents through the nozzle (24) and retracting the nozzle (24), (4) inserting a contents-pouring device (5, 5?) in the parison located above the plastic container main body (2), (5) clamping a mold (31) for a protective case, and (6) forming a protective case (6) with the parison located above the container main body (2).

Abstract: A carpule and its method of manufacture, the carpule tubular body composed of a polypropylene or similar polymer, the tubular body being sealed at one end by a seal of a thermoplastic vulcanizate (TPV) or similar polymer, the seal having been injection molded in contact with the tubular body prior to full curing of the material composing the tubular body, such that a chemical fusion bond is created between the seal and the tubular body.

Abstract: According to one exemplary embodiment, a surgical instrument for insertion in an incision during surgical treatment and removal of tissue includes an inner elongated needle having an ovoid shape and a bore extending therethrough; and a hollow sleeve that surrounds the ovoid shaped needle such that two side regions of the needle contact an inner surface of the sleeve at two locations so as to define a pair of fluid channels that are located between convex outer surfaces of the needle and the inner surface of the sleeve. The shape of the sleeve, when deformed by insertion of the needle, is configured to be received within the incision during the surgical treatment and removal of the tissue so as to plug opposite ends of the incision and provide an at least substantially closed surgical site.

Abstract: An actuating mechanism for a hypodermic syringe comprises a flexible tongue (48) allowing the actuating mechanism to be bent to receive a cartridge (10) of injectant closed at its forward end with a septum (14) and at its rearward end with a slidable bung (18). The forward end of the cartridge (10) is fitted into a socket (36) wherein the tail (34a) of a hypodermic needle (34) pierces the septum (14) to access the injectant. With the cartridge (10) fitted, the tongue (48) is straightened, and a spring clip (50) holds the cartridge (10) in position. A plunger (38) can then be depressed, though a guide (42), to drive the bung (18) forward and make the injection. The cartridge (10), which may be a conventional cartridge of any kind, keeps the assembly rigid in use, and the whole assembly is disposed of after a single use, without dismantling.

Abstract: The delivery of a fluid cutaneously is effected by generating a suction force on a surface of a housing. A surface of a cutaneous layer is received under the suction force about which the proximal end of a needle thereby to pierce the cutaneous surface and to effect an injection of fluid. There is generated a suction force to operate the movement of a needle in the housing. The needle is moved under the suction force from the housing thereby to permit piercing a cutaneous layer. The bladder for containing fluid is emptied under the suction into the distal end of the needle and thereby permit the expulsion of fluid through the proximal end of the needle for injection below the cutaneous layer.

Abstract: The present invention discloses novel photoactive compounds that may be crosslinked to target substrates. Methods for the preparation and use of the compounds, as well as compositions comprising them, are also disclosed.

Abstract: A method for treating priapism in a mammal by administration of a botulinum toxin.

Abstract: An automated injection device for administration of one or more liquid medicaments that is particularly useful for self-administration of liquid medicaments such as those used to treat anaphylactic shock, heart attack, exposure to toxic agents, or other conditions may include a number of features designed to reduce both the size and complexity of the device. With reduced size, the device may provide greater convenience and portability. Importantly, the reduced size may encourage more users to carry the device, and thereby reduce the risks associated with the conditions mentioned above. With reduced complexity, the device can be constructed at a lower cost. Moreover, the device can be more reliable and simple to operate.

Abstract: An improved single- or multiple-dose syringe having a conventional housing and an improved plunger configuration carrying a medicament- or saline-filled cartridge the contents of which are sequentially dispensed after the dispensing of a volume of a drawn-up primary fluid. A method for sequential administration of medicinal fluids using the improved syringe is also a part of the invention.

Abstract: A flexible tubing device is used for intravenous infusion of medicine, particularly antibiotics, to all lumens of a multi-lumen central venous line catheter. The single input arm of the tubing device is connected to a source of medicine, and each of the several output legs of the tubing device are connected to different ports on the central venous line catheter. It allows a single input to be divided into a plurality of outputs. To allow this, the free end of the input arm has a female tube connector fitting while the free end of each of the output legs have a male tube connector fitting.

Abstract: To control the reflex response of a muscle or muscular group articulating a joint of a living body, the method and device apply an external pressure to the mechano-receptors guiding the natural reflex mechanism of the muscle or muscular group. The mechano-receptors include skin mechano-receptors and deeper joint mechano-receptors. To increase the reflex response of the muscle or muscular group, a light pressure intensity .ltoreq.200 mmHg is applied to stimulate only the skin mechano-receptors and thereby increase the reflex response of the muscle or muscular group. To inhibit the reflex response of the muscle or muscular group, a high pressure intensity .gtoreq.400 mmHg is applied to stimulate the deeper joint mechano-receptors such as the Golgi tendons to thereby increase the reflex response of the muscle or muscular group.

Abstract: A camouflaged injection needle is disclosed including a shaft, a flexible ellipsoid tip at one end of the shaft and a sharp needle tip positioned within the flexible tip and axially aligned with the shaft. The sharp needle tip is capable of piercing through the flexible tip and into an outer human tissue when the flexible tip is positioned on the outer human tissue and the shaft is urged in the direction of the outer human tissue. The injection needle is camouflaged to resemble a cotton swab. This reduces pre-injection anxiety of the patient.

Abstract: Direct injection of sphincteric botulinum toxin is disclosed as an effective, safe and simple method of treatment for disorders of gastrointestinal muscle or smooth muscles elsewhere in the body, with results that appear to be sustained for several months. Muscle disorders which are suitable for such treatment include achalasia, isolated disorders of the lower esophageal sphincter, gastroparesis, hypertrophic pyloric stenosis, sphincter of Oddi dysfunction, short-segment Hirschsprung's, anal fissure, hemorrhoids, proctalgia fugax, irritable bowel syndrome, disorders of the upper esophageal sphincter, vasospastic disorders, and disorders of uterine and bladder spasm. Devices suitable for delivering this therapy are also disclosed.

Abstract: A disposable vaccine delivery system containing a single dosage vaccine, having a compressible "hour-glass" shaped container portion filled with a needle, containing the vaccine, enclosed in a rigid clamp assembly having syringe-type activation means for compressing and expelling the vaccine contents into the human subject.

Abstract: A unit dose syringe comprises a fluid-containing plastic bag with an attached needle and a dimensionally-stable shell like a woman's compact. The shell contains a thumb-operated slider assembly for advancing the needle to an exposed position for fluid delivery. The syringe also includes a spring-biasing arrangement to return the needle, automatically, to the protected position, after use, and a means for rupturing the bag and retaining the needle in the protected position.

Abstract: An acupuncture needle-tank apparatus for mix use comprising a needle of the type used in acupuncture, provided with an internal channel constituting a cannula suitable to let pass a liquid or viscous product therethrough, connected to a tank without piston, containing said product, wherein the cannula has an external diameter under 0.3 mm and the tank being of an external diameter under 15 mm. The tank is further characterized in that it is of a material deformable by simple finger pressure to allow the flow of the product it contains.

Abstract: A safely disposable unit dose syringe is achieved by sealing the fluid to be administered into a plastic or otherwise inexpensive, deformable container such as a plastic baggie and attaching to the container a needle which can be moved from a protected compartment to an exposed position for administering the fluid. The needle is withdrawn to the protected position after use for safe disposal. After use the container cannot be refilled without the use of fairly elaborate and costly equipment. The syringes can be produced in the form of a bandoleer for administration by means of a gun-like device, the contents of each syringe being delivered in response to the squeezing of a trigger-like mechanism.

Abstract: A single-use disposable syringe. In the syringe, a reservoir is formed of two sheets of thermoplastic material having expanded central portions that form a pair of convex domes. Both of the domes are compressible, and a connecting member spaces apart the domes. In response to complete compression of both of the central portions together, the reservoir substantially collapses and each of the domes becomes concave to prevent the reservoir from being reformed and to prevent reuse of the syringe. After partial compression of both of the central portions together and partial collapse of the reservoir, the central portions expand to reform the reservoir and draw fluid into the reservoir, thereby aspirating a hypodermic needle.

Abstract: A single use, single dose injection administering device including a drug or vaccine containing body and a needle wherein the sidewalls have memory causing at least one sidewall to collapse into the other during the administration of the vaccine.

Abstract: A prepackaged, injectable pharmaceutical hypodermic needle has semi-rigid outer container, supported within which is a substantially non-resiliant inner container containing a pre-measured dose of the pharmaceutical. A cannula extending through and fixed with respect to the outer container is adapted to pierce the inner container for injection of the pharmaceutical upon manual collapsing or squeezing of the outer container. Air flow openings in the outer container permit the flow of air into the cavity between the inner and outer containers upon manual release during successive manual compression or squeezing operations, thereby obviating the possibility of negative air pressure being exerted upon the inner container.