Abstract: A tubing assembly having a signal generator placement control device for use in conjunction with electronic catheter guidance systems. The control device facilitates control of the position the guidance systems' signal generator relative to the end of the tubing assembly. The tubing assembly includes a tubular insulator coupled to one end of the control device, and the tubing assembly includes a tubular connector attached to the other end of control device. Also, the tubing assembly includes a catheter attached to the tubular connector and an end member attached to the catheter.

Abstract: An insert for a catheter system can include an insert housing which defines a portion of a fluid pathway of the catheter system, a cartridge positioned within the insert housing in a manner to allow fluid flow along the fluid pathway such that fluid contacts the insert during the fluid flow, and an active agent associated with the cartridge. The active agent and the cartridge can be adapted to release active agent from the cartridge during the fluid flow.

Abstract: The present invention relates to a medicament delivery device comprising a housing (10, 20, 24, 30), a biased medicament delivery member guard (64) arranged movable in relation to the housing from a proximally extended position to a retracted position, a power pack (87) comprising a plunger rod (88) and a force element (118) arranged to act on said plunger rod (88), which power pack (87) is actuated by a release clip (96) movable in relation to the housing and arranged to said plunger rod (88) for releasibly holding said plunger rod (88) with the force element (118) in a tensioned state; a rotator (82) rotatably arranged inside said housing, which rotator (82) is arranged with a guide element (80) and a medicament delivery member guard lock element (84, 86) on its outer surface, wherein said medicament delivery member guard (64) is arranged with release clip activation elements (112) operably arranged to act on said release clip (96) for releasing said plunger rod, and wherein said medicament delivery member

Abstract: A drug delivery device comprising a drug container extending between a distal end and a proximal end and is capable of being compressed into a single plane; a body extending between proximal and distal ends comprising a hollow space for containing the drug container; and a plunger extending between proximal and distal ends, wherein the distal end of the plunger engages telescopically with the proximal end of the body, wherein the plunger comprises at least one pair of protrusions, wherein the protrusion is capable of compressing the drug container as the plunger moves towards the proximal end of the drug delivery device, by applying a force to the drug container that is perpendicular to the movement of the plunger.

Abstract: A method of treating midface volume deficit in a person is provided. The method generally includes administering a dermal filler, such as a hyaluronic acid based dermal filler, in a sequence of injections that enhance effectiveness and/or duration of the filler. The method may include initially introducing a volume of the filler into at a zygomaticomalar region of the face prior to introducing one or more additional volumes of the filler into the anteromedial region and the submalar region, such that the duration of effectiveness of the treatment is improved, and less filler is required to achieve a desired correction.

Abstract: The subject invention provides a drug delivery device for injecting medicament which includes: a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and, an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.

Abstract: Various embodiments of a device, a kit and method for delivering a drug depot are disclosed. The device comprises a housing including a lower body, an upper body, a ring member; and a drug cartridge. The lower body defines a lower body channel. The upper body defines an upper body channel. The drug cartridge defines a depot channel. The ring member is disposed extending upward from an annular step surface of the lower body toward a housing upper end. The ring member includes indicia indicating a characteristic of one or more drug depots in the drug cartridge. A plunger has a push rod for expelling the drug depot through the cannula to a site in the patient. A kit comprises the above components. A method includes assembling the components including selecting a ring member having indicia corresponding to one or more drug depots in the drug cartridge.

Abstract: The present invention generally provides a device for inserting needles and alleviating the discomfort associated with needle insertion. In certain embodiments, the device is suited for injecting butterfly needles and particularly butterfly needles that are attached to infusion tubing. The patient or caregiver loads a butterfly needle with tubing attached into the base of the drive plunger. The needle with tubing attached is retracted into the housing of the device by retracting the inner plunger. Once retracted, the device is activated and ready to administer a needle into the tissue of a patient. The device is then placed on the location of the skin where injection is desired. The surface that contacts the skin may be textured and may include a contact switch that causes the device to vibrate when slight pressure is applied through contact with the skin.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), and a piston rod (30) coupled to the housing (10) and to a drive sleeve (40). Rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10). The piston rod (30) is coupled to the housing (10) via a threaded interface (16, 31) with at least two different pitches.

Abstract: An auto-injector for administering a dose of a liquid medicament includes a case and a carrier subassembly with a carrier slidably arranged inside the case. The carrier can contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding drive spring load to a syringe stopper. The syringe can jointly, axially translate with the carrier. The drive spring acts between the carrier and the plunger. In an initial state, the plunger is locked to the carrier by a ramped engagement to the carrier and is prevented from rotating out of this engagement depending on a longitudinal position of the carrier in the case. The plunger can be released for rotating out of the ramped engagement when the needle reaches nearly a predefined injection depth on translation of the carrier in the proximal direction for advancing the needle beyond a proximal end of the auto-injector.

Abstract: Disclosed are devices and methods for creating a bore in bone. The devices and methods described involve driving a rotating bit in an axial direction such that both rotation and linear movement are controlled and measurable. The instrument is useful for a surgeon to control and simultaneously measure the travel of the tool into the bone and prevent injury to surrounding structures.

Abstract: A valve for a tubing kit used provides a resilient element naturally moving to a closed state to reduce opportunity for inadvertent leakage of medicine and to reduce effort required by healthcare personnel to seal the fluid line. In one embodiment the resilient element is a spring serving to compress the walls of IV tube in the closure and in a second embodiment the resilient element is an elastomeric member that is deformed to provide an opening to allow passage of fluid through the fluid line.

Abstract: An adapter for a syringe has a base portion having an insertion hole configured to surround and engage at least a portion of a barrel of the syringe. The base portion includes a top surface and an opposing bottom surface. At least one projection extends upwardly from the top surface of the base portion. At least one ramp portion is located proximate the at least one projection. A flange portion extends laterally outwardly from the base portion. The flange portion includes a top surface and an opposing bottom surface. The top surface of the base portion extends generally parallel to and is spaced between the top and bottom surfaces of the flange portion.

Abstract: Leads having distal electrodes may be used in application of test stimulation for purposes of implanting a lead having a fixation element distal to an electrode array. The fixation element is proximal the distal electrode. Accordingly, the distal electrode may be advanced beyond a distal end of an introducer while the fixation element may be retained in a retracted configuration by the introducer. If the test signals applied by the distal electrode indicate that the distal electrode is in the desired location of the patient, a series of markings on the lead may be used to facilitate placement of the electrode array at the location previously occupied by the distal electrode; i.e. the desired location of the patient. The electrodes of the electrode array may then be used to provide therapy to the patient.

Abstract: An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the laterovertically-expanding frame and both the stabilizer and the one or more tensioners are configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.

Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.

Abstract: Plunger systems for expelling a liquid drug from a drug container within a wearable drug delivery device are provided. A rotation system coupled to a plunger rotates the plunger about a central axis of the plunger to overcome a static friction between the plunger and the drug container. After rotating the plunger, a drive system moves the plunger forward into the drug container to expel the liquid drug for delivery to the patient. A collapsible plunger includes a cavity. A radial torsion spring positioned in the cavity can provide an outward radial force on the collapsible plunger. The cavity enables the collapsible plunger to compress radially when entering and passing through a region of a drug container having a relatively narrower width. The radial torsion spring can radially expand the collapsible plunger when entering and passing through a region of the drug container having a relatively wider width.

Abstract: The infusion cannula system for pars plana vitrectomy includes a port (100) mounted over a sclerotomy on the patient's eye (200) and an infusion cannula assembly (400) adapted for connection to a vitrectomy machine that maintains pressure in the eye during the procedure. The port (100) includes an external cylindrical shell (10) that is kept stationary and an internal hub (14) having an insertion tube (17) extending therefrom. The internal hub (14) is threadable into the cylindrical shell (10) in increments to control the depth of penetration of the insertion tube (17) through the sclerotomy incision into the vitreous cavity. The infusion cannula (25) is introduced into the eye (200) through the insertion tube (17) to the desired depth. The internal hub (14) may have a pointer (15) that points to calibration indicia on the cylindrical shell (10) corresponding to the depth of insertion of the infusion cannula (25).

Abstract: A device for inserting an infusion cannula, or sensor, into a patient is presented. The device comprises an insertion needle removable within the infusion cannula, a handle connected to the insertion needle, and a needle cover. The needle cover pivotably mounted on the handle is rotatably movable between a first position, i.e., the front of the insertion needle is in the needle cover, and a second position, i.e., the front is exposed. An infusion site interface comprises a body mounted on a pad attached to the patient; an infusion cannula for inserting into the patient that is connected to the body; a cavity within the body fluidly connected to the cannula; and a septum that seals closed the cavity. The septum is penetrable by an insertion needle in the infusion cannula and by a hollow needle of an infusion tubing connector coupled to the infusion site interface.

Abstract: Disclosed are methods, apparatus, and systems useful for detecting leaks in pleural tissue. Also disclosed are methods of detecting and sealing such leaks. Indicator dye or stain is aerosolized and delivered to the lung via anesthetic equipment, oxygen tube, endoscope, or other suitable equipment, the dye is allowed to travel through the lung along the path or paths of least resistance emerging at the surface of the lung, staining the tissue indicative of a leak. Some embodiments include introducing one part of a two part sealant with the dye, and applying the second part of the sealant to the stain identified leak locations.

Abstract: A device for preparing adipose tissue for transplantation, from lobular fat extracted, for instance, by liposuction. The device comprises at least one washing and separating container (1) having a washing chamber (11) for washing the liposuctioned material, which washing and separating container (1) has at least one inlet (12) and at least one outlet (13) for the liposuctioned material to enter the washing chamber (11) through the inlet (12) and for at least part of said material, the fluid component, to exit said chamber 11 through the outlet 13. The washing and separating container (1) is coupled to stirring means via coupling means (2) for releasably coupling said washing and separating container (1) to said stirring means, drive means being provided for driving said stirring means.

Abstract: The present invention relates to intervertebral disc-related pain, such as low back pain, chronic low back pain, neck-pain, chronic neck pain and coccygodynia. A composition for use in the treatment of intervertebral disc-related pain is provided. The composition comprises lactic acid and has a pH below 4. The composition is administered into a disc space comprising the nucleus pulposus of an intervertebral disc.

Abstract: The present invention relates to an injection device for dispensing of a liquid medicament, the device comprising: a base (10), a medicament reservoir (20) displaceably arranged on the base (10) and containing the liquid medicament (25), an injection needle (30) displaceably arranged relative to the base (10) between a retracted position (30a) and an extended position (30b), a pressure container (40) containing a pressurized fluid (24), a reservoir displacing arrangement (50) coupled with the pressure container (40) to displace the medicament reservoir (20) into a dispensing position (20b), in which the medicament reservoir (20) is in fluid communication with the injection needle (30), a needle displacing arrangement (60) coupled with the pressure container (40) to at least displace the injection needle (30) into the extended position (30b).

Abstract: An assembly including a needle (3) for administering a fluid is presented. The needle (3) comprises a hollow needle body (4) to guide the fluid. The needle body (4) is furthermore formed such that an inlet section (20) of the needle body (4) defines a first flow direction for the fluid and an outlet section (21) of the needle body (4) defines a second flow direction for the fluid, wherein the first flow direction is inclined with respect to the second flow direction.

Abstract: An autoinjector includes a case, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case, a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier, and a trigger button operably coupled to the carrier. The case includes a rib. The needle shroud is movable between a first extended position, a retracted position, and a locked second extended position. The carrier is adapted to hold a medicament container and movable from a first axial position to a second axial position relative to the case. The carrier abuts the rib in the first axial position and the needle shroud is in the first extended position and disengages the rib when the needle shroud is in the retracted position and the trigger button is pressed to advance the carrier to the second axial position.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament comprising a clicker arrangement. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) coupled to the dose selector (80) and arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), a piston rod (30) coupled to the housing (10) and to a drive sleeve (40) such that rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10), a clutch (120) arranged between the number sleeve (60) and the drive sleeve (40), and a dispense clicker comprising a flexible arm (123) and a toothed profile (75). The device further comprises a button (70) operable to effect dose dispensing.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), a piston rod (30) coupled to the housing (10) and to a drive sleeve (40) such that rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10) and a clutch mechanism arranged between the number sleeve (60) and the drive sleeve (40).

Abstract: A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device includes a cartridge containing liquid, a dosing element, which rotates during dose selecting, a last dose nut coupled to the dosing element during dose selecting such that rotation of the dosing element causes an axial movement of the last dose nut, and a stop element, which is provided on the dosing element and which blocks further movement of the last dose nut, if a dose is selected corresponding to the amount of liquid left in the cartridge. The device further includes a last dose sleeve rotationally coupled to the dosing element during dose selecting and rotationally decoupled from the dosing element during dose dispensing.

Abstract: A needle guard device mountable to a pre-filled syringe in its ready-to-fill state. The device includes a lock collar and a device shield biased to move relative to the lock collar. The lock collar interfaces with the syringe neck to attach the device to the syringe. With the removal of a needle shield assembly comprising rigid and soft needle shields, the lock collar and device shield are free to move proximally along the syringe neck and interact with a syringe step down area to activate the device. As the device moves proximally, retention arms of the device shield interact with the syringe step down, causing the arms to deflect radially outwards to disengage from the lock collar triggering the device shield to move from a first position to a second position.

Abstract: A pen injector apparatus is disclosed for use with a cartridge to deliver a plurality of single metered doses therefrom. The injector apparatus includes a body arranged to provide a conduit which, in use, provides a fluid communication path between the cartridge and a delivery needle and a mechanism arranged to expel therapeutic material from the cartridge. The mechanism is arranged to draw therapeutic material from the cartridge into the conduit by negative pressure and discharge a metered dose from the conduit via the delivery needle.

Abstract: An autoinjector includes a case having a rib, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case and adapted to hold a medicament container, and a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier. The needle shroud is movable between a first extended position, a retracted position and a locked second extended position. The carrier is movable from a first axial position to a second axial position relative to the case. The collar abuts the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar disengages the rib when the needle shroud is in the retracted position and the carrier is in the second axial position.

Abstract: An autoinjector includes a case adapted to hold a medicament container, a needle shroud telescopically coupled to the case, and a plunger slidably disposed in the case. The needle shroud is movable between a first extended position, a retracted position, and a second extended position relative to the case. The plunger is movable between a proximal position, an intermediate position, and a distal position relative to the case. When the plunger is in the intermediate position and the needle shroud is in the retracted position, the plunger abuts the case to prevent the needle shroud from returning to the extended position. When the plunger is in the distal position and the needle shroud is in the second extended position, the plunger abuts the case to prevent the needle shroud from returning to the retracted position.

Abstract: Devices, kits, and methods of treatment are described. More particularly, methods of treating tissue of a passage wall defining a bodily passage, such as a sinus cavity, airway, or sinus passage are described. An exemplary method utilizes an elongate member having an elongate member proximal end, elongate member distal end, and an elongate member body that defines a curve.

Abstract: A set connector assembly for a fluid infusion device is provided. The set connector assembly includes a connector having a body. The body defines a graspable portion and a coupling portion, and the coupling portion is to be received within a portion of the fluid infusion device. The graspable portion has at least one locking tab to lock the connector to the fluid infusion device, and the graspable portion is movable relative to the body to move the connector between a first, locked position and a second, unlocked position relative to the fluid infusion device.

Abstract: Devices as described herein for localizing an intracerebral hematoma or blood mass in brain tissue include a cannula and one or more sensor wires operably connected between a glucose meter and one or more glucose sensors for determining the location and margins of an intracerebral blood mass.

Abstract: A device having a plurality of anchors configured to be driven into a tissue, and a closure element extending between the anchors and configured to urge the anchors toward each other, closing a wound and complying with motion of the tissue.

Abstract: A self expanding cannula with improved drainage properties based upon its greater length is provided, along with methods of using the cannula in cardiopulmonary bypass.

Abstract: A surgical instrument for dispensing a fluid includes a housing and a dispensing shaft. The surgical instrument further includes a dispensing assembly connected to the housing, which includes a dispensing chamber for holding the fluid before it is dispensed. A container is included in which the fluid is stored before the surgical instrument is used. A transfer assembly is included and is connected to the housing which is operable to open the container and transfer the fluid from the opened container to the dispensing chamber before the dispensing assembly is operated.

Abstract: A vascular closure device, having an insertion sheath and a vascular closure implant positioned at least partially in the insertion sheath. The vascular closure implant may have an anchor element, the anchor element including an expandable material, a first puncture contact portion, a bend portion connected to the first puncture contact portion, the bend portion including a bend, and a second puncture contact portion connected to the bend portion. The vascular closure implant may also include a plug element coupled to the bend portion of the anchor element. The anchor element may be formed of an expandable material having the same or a different expansion rate than a material forming the plug element. The vascular closure device may additionally include a locator tube having a vessel locator positioned at least partially in the locator tube. The vessel locator may also have an elongated member that includes a superelastic material.

Abstract: The various embodiments described herein relate to fabricating and using open microfluidic networks according to methods, systems, and devices that can be used in applications ranging from home-testing, diagnosis, and research laboratories. Open microfluidic networks allow the input, handling, and extraction of fluids or components of the fluid into or out of the open microfluidic network. Fluids can be inserted into an open microfluidic channel by using open sections of the open microfluidic network. Passive valves can be created in the microfluidic network, allowing the creation of logic circuits and conditional flow and volume valves. The fluid can be presented via the microfluidic network to diagnostic and analysis components. Fluids and components of the fluid can be extracted from the open microfluidic network via functional open sections that are easily interfaced with other microfluidic networks or common laboratory tools.

Abstract: Automatic injection device includes a housing, a syringe, a plunger, and a syringe carrier. The housing includes a barrel. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier can have at least one opening and at least one pair of legs defining at least a portion of the at least one opening.

Abstract: Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

Abstract: The pharmaceutical injection device of the present invention comprises a cartridge holder, a main case, a piston, a motor, an opening component, an open/closed detection switch, and a controller. The motor drives the piston in either an insertion direction in which the piston is inserted into a pharmaceutical cartridge, or a pull-out direction in which the piston is pulled out of the pharmaceutical cartridge. The opening component opens the cartridge holder in conjunction with the movement of the piston in the pull-out direction. The open/closed detection switch detects whether the cartridge holder is open or closed. When the open/closed detection switch detects that the cartridge holder is open, the controller controls the motor so as to stop the piston.

Abstract: Automatic injection device includes a housing, a syringe, a plunger, and a syringe carrier. The housing includes a barrel between a first end and a second end. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier can be substantially transparent. The syringe carrier can have first and second legs and an extension disposed therebetween, and at least a portion of the extension can be configured to align with the window and the reservoir when the syringe carrier is in the first position.

Abstract: A total dose of a therapeutic agent to be delivered to a patient by an infusion device over a total period of time is automatically divided into a plurality of unit doses to be delivered to the patient over a plurality of unit periods of time. The infusion device is automatically programmed to deliver one of the unit doses of the therapeutic agent to the patient over its respective unit period of time, after which the one unit dose is delivered, and a determination is made of whether an error occurred in delivering the one unit dose to the patient. Delivery of the total dose of the therapeutic agent to the patient may include iteratively automatically programming the infusion device to deliver successive unit doses upon determining that no error occurred in delivering a previous unit dose to the patient. Accordingly, the risk of improperly dosing the patient with the therapeutic agent in an event of a software or hardware anomaly within the infusion device is prevented or reduced.

Abstract: A trigger assembly for an automatic injection device which by its operation releases a biased element of the device for movement. The trigger assembly includes a button pressable by a user, and a lock member. Prior to the button being plunged, a blocking element on the button is abutted by a button-engaging surface of the lock member to prevent lock member rotation, thereby allowing an engagement surface on the lock member to remain in engagement with an engagement surface of the biased element so as to restrain motion of the biased element. When the button is plunged, the blocking surface moves clear of the button-engaging surface to allow the lock member to rotate, during which rotation the engagement surfaces disengage to release the biased element for movement.

Abstract: A drug delivery device is provided for delivering a drug to a target tissue site. The drug delivery device comprises a body comprising a proximal end and a distal end and a chamber disposed therebetween. An upper portion is disposed about the proximal end of the body. A retaining member is disposed within a wall of the body and engageable with the chamber and a plunger is configured for disposal within the upper portion and the chamber. The upper portion is movable about the proximal end of the body to open the chamber such that the plunger is disposed within a passageway defined within the chamber, and movement of the plunger in a distal direction pushes the retaining member such that the drug moves out of the body. Methods are also disclosed.

Abstract: A tubing assembly having a signal generator placement control device for use in conjunction with electronic catheter guidance systems. The control device facilitates control of the position the guidance systems' signal generator relative to the end of the tubing assembly. The tubing assembly includes a tubular insulator coupled to one end of the control device, and the tubing assembly includes a tubular connector attached to the other end of control device. Also, the tubing assembly includes a catheter attached to the tubular connector and an end member attached to the catheter.

Abstract: An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the laterovertically-expanding frame and both the stabilizer and the one or more tensioners are configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.

Abstract: A system, method or apparatus to detect abnormalities in delivery of a fluid may include an infusion apparatus that is controllable to cause one or more perturbations in a fluid flow (e.g., each of the one or more perturbations in the fluid flow may result in a measurable perturbed force response). A force signal representative of the perturbed force response may be used to determine an integrated perturbed force response value (e.g., using integration of the force signal over a perturbation time period; the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation over an equilibrium force). A ratio between the integrated perturbed force response value and a normalizing value (e.g., based at least on a maximum perturbation force of the perturbed force response) may be used to determine if fluid flow is occluded.