Component Of Blood Removed (i.e., Pheresis) Patents (Class 604/6.01)
-
Patent number: 8808217Abstract: A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.Type: GrantFiled: May 2, 2013Date of Patent: August 19, 2014Assignee: Haemonetics CorporationInventors: Toshiyasu Ohashi, Etienne Pagès, Dominique Uhlmann, Pascal Maillard, Michael Ragusa
-
Patent number: 8764695Abstract: The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.Type: GrantFiled: September 28, 2012Date of Patent: July 1, 2014Inventor: Isaac Eliaz
-
Publication number: 20140148750Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.Type: ApplicationFiled: January 29, 2014Publication date: May 29, 2014Applicant: Haemonetics CorporationInventors: Etienne Pagès, Michael Ragusa
-
Patent number: 8708944Abstract: A system for harvesting a fibrin clot and depositing that fibrin clot into a wound site during a surgical procedure, the system comprising: (i) blood drawing apparatus for drawing blood; (ii) extraction apparatus for extracting fibrin from blood so as to form a fibrin clot; (iii) configuring apparatus for molding, cutting and shaping the fibrin clot into a desired configuration; and (iv) dispensing apparatus for reliably and controllably dispensing the fibrin clot at a selected location in the body.Type: GrantFiled: March 29, 2010Date of Patent: April 29, 2014Inventors: Javin C. Pierce, Peter Kurzweil
-
Patent number: 8702637Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.Type: GrantFiled: April 14, 2008Date of Patent: April 22, 2014Assignee: Haemonetics CorporationInventors: Etienne Pagès, Michael Ragusa
-
Patent number: 8684959Abstract: An extracorporeal blood treatment apparatus comprises a sensor (10) for emitting a signal indicating a change of hematic volume of an individual (7) subjected to a treatment and a weight loss system for actuating the individual's weight loss. A control unit (20) receives an effective weight value of the individual and a desired weight loss value and from these values determines a desired value of a change in hematic volume at end of treatment. The weight loss system is controlled on a basis of the hematic volume change signal and the desired value of the hematic volume change. The apparatus enables automatic control of a dialysis operation while preventing some complications arising from hypotension.Type: GrantFiled: July 3, 2009Date of Patent: April 1, 2014Assignee: Gambro Lundia ABInventors: Francesco Paolini, Francesco Fontanazzi, Fabio Grandi
-
Patent number: 8647289Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.Type: GrantFiled: March 31, 2011Date of Patent: February 11, 2014Assignee: Haemonetics CorporationInventors: Etienne Pagès, Michael Ragusa
-
Patent number: 8632486Abstract: An access disconnect system includes a blood processing machine having a blood pump operable with blood tubing, first and second conductive contacts located in the blood tubing on an arterial tubing side of a blood filter. The first conductive contact is located upstream of the blood pump and the second conductive contact is located downstream of the blood pump. The first and second conductive contacts are positioned and arranged to form a conductive circuit including a vascular system of a patient and the blood processing machine. The system further includes a source of electric current connected to at least one of the first and second conductive contacts and a transmitter for sending a signal indicative of an amount of current flowing through the conductive circuit when the source of electric current is applied.Type: GrantFiled: January 4, 2012Date of Patent: January 21, 2014Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventor: Matthew R. Muller
-
Patent number: 8628489Abstract: A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may also include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, and returns uncollected blood component to the subject. Each line may have a pump that controls flow through the line. The blood component separation device separates the drawn blood into a first blood component and a second blood component, and may be configured to send the first blood component to a first blood component bag.Type: GrantFiled: April 14, 2008Date of Patent: January 14, 2014Assignee: Haemonetics CorporationInventors: Etienne Pagès, Michael Ragusa
-
Patent number: 8603346Abstract: Disclosed is an apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.Type: GrantFiled: September 22, 2011Date of Patent: December 10, 2013Assignee: Biomet Biologics, LLCInventors: Michael D. Leach, Joel C. Higgins
-
Patent number: 8556843Abstract: Methods for treating malaria are provided, the treatment comprising the step of removing malaria-infected red blood cells from the patient's blood. Blood is drawn from the patient's circulatory system and circulated through a blood purification device that selectively eliminates the infected red blood cells from all other blood's components and replaces the cleansed blood back into the patient's circulatory system. A blood purification device, which is useful to perform the therapeutic methods of the invention, is also provided. The device leverages the magnetic properties of the hemozoin contained within the infected red blood cells and comprises one or more separation chambers (4) though which blood flows through a high-gradient magnetic field generated by an array of wires (5) separated from the chambers and not in contact with the patient blood.Type: GrantFiled: February 2, 2009Date of Patent: October 15, 2013Assignee: AccelDxInventors: Alberto Gandini, Roy Weinstein, Ravi-persad Sawh, Drew Parks
-
Publication number: 20130261528Abstract: An apheresis tubing set comprises a cryocyte bag for collecting cells separated during apheresis. The cryocyte bag may comprise a mixing compartment in fluid communication with a cell storage compartment, wherein the mixing compartment comprises a cryoprotectant port and a cell sample port and wherein the storage and mixing compartments are in fluid communication via a mix conduit.Type: ApplicationFiled: November 6, 2012Publication date: October 3, 2013Inventor: Glen James Wicks Delaronde-Wilton
-
Publication number: 20130240422Abstract: A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.Type: ApplicationFiled: May 2, 2013Publication date: September 19, 2013Applicant: Haemonetics CorporationInventors: Toshiyasu Ohashi, Etienne Pagès, Dominique Uhlmann, Pascal Maillard, Michael Ragusa
-
Publication number: 20130244897Abstract: The invention relates to novel marker sequences for multiple sclerosis and to the use thereof in diagnosis as well as to a method for screening potential active ingredients for multiple sclerosis diseases the marker sequences. The invention further relates to a diagnostic device containing such marker sequences for multiple sclerosis, especially to a protein biochip and the use thereof.Type: ApplicationFiled: October 4, 2011Publication date: September 19, 2013Applicant: Protagen AGInventors: Angelika Lueking, Axel Kowald, Heike Göhler
-
Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
Patent number: 8535421Abstract: A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.Type: GrantFiled: October 8, 2010Date of Patent: September 17, 2013Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul J. Vernucci -
Patent number: 8539573Abstract: Systems, methods, apparatus, and computer readable media are provided for disposable component authentication with respect to a biological fluid processing device instrument. An example instrument authentication system includes a computer facilitating configuration and operation of the biological fluid processing instrument using a disposable component. A first interface is provided by the computer and is used by a service technician to configure the biological fluid processing instrument for a number of disposable components and to provide a service technician with a validation code. A key generator is to accept the validation code from the service technician and generate an authentication key in response to the entered validation code. A second interface is provided by the computer, the second interface prompting the service technician to enter an authentication key, wherein the authentication key authorizes use of a certain number of disposable components for the biological fluid processing instrument.Type: GrantFiled: February 19, 2010Date of Patent: September 17, 2013Assignee: Fenwal, Inc.Inventors: Douglas Newlin, Kevin Krause, Robert Crampton, John T. Foley, Brian Case, William Cork
-
Patent number: 8517967Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.Type: GrantFiled: November 8, 2011Date of Patent: August 27, 2013Assignee: Velico Medical, Inc.Inventors: Keith Rosiello, Henrik Clausen
-
Patent number: 8511479Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.Type: GrantFiled: January 24, 2012Date of Patent: August 20, 2013Assignee: ThermoGenesis Corp.Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
-
Patent number: 8511480Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.Type: GrantFiled: March 30, 2012Date of Patent: August 20, 2013Assignee: ThermoGenesis Corp.Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
-
Patent number: 8506823Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.Type: GrantFiled: January 26, 2012Date of Patent: August 13, 2013Assignee: ThermoGenesis Corp.Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
-
Publication number: 20130197419Abstract: Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient. The processing set remains connected to the patient during the entire ECP treatment procedure and provides an online, sterile closed pathway between the separation chamber and the treatment chamber.Type: ApplicationFiled: January 3, 2013Publication date: August 1, 2013Applicant: Fenwal, Inc.Inventor: Fenwal, Inc.
-
Patent number: 8496606Abstract: A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed plasma to the membraneless separation device. A treatment protocol can include ultrafiltering blood of a patient using the ultrafiltration device and performing a secondary treatment on the blood of the patient at a reduced frequency compared to the ultrafiltering. The membraneless separation device can also be applied to treatment, analysis, and/or exchange of plasma from blood, or combined with conventional dialyzers to perform dialysis on a cytoplasmic body-free plasma fraction.Type: GrantFiled: February 4, 2009Date of Patent: July 30, 2013Assignee: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Ilan K. Reich, Stanley Cortell
-
Publication number: 20130190674Abstract: Systems and methods for using physiological data in a medical device are disclosed. The physiological data may be measured by a vital sign reader and received by a processing circuit associated with the medical device. The processing circuit may automatically adjust the operation of the medical device during a medical procedure based on the physiological data. In some implementations, the processing circuit may mirror a memory partition to a redundant storage device, allowing for uninterrupted execution of the medical procedure in the event of a memory failure condition.Type: ApplicationFiled: January 17, 2013Publication date: July 25, 2013Applicant: Fenwal, Inc.Inventor: Fenwal, Inc.
-
Publication number: 20130184229Abstract: Compounds, compositions and methods are provided for treating cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood. More specifically, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described.Type: ApplicationFiled: March 5, 2013Publication date: July 18, 2013Applicant: GLYCOMIMETICS, INC.Inventor: GlycoMimetics, Inc.
-
Patent number: 8480608Abstract: A blood processing system includes a flow reversing device with at least an air sensor in the venous line located near the patient. During treatment, blood flow is reversed to cause air to infiltrate the blood lines if any disconnections or breaks in the blood line are present. One means for placing the sensor close to the patient is to provide the flow switching device aid sensors in a small lightweight module that can be located close to the treatment machine. Another is to provide a module with just the sensors near the access.Type: GrantFiled: March 30, 2011Date of Patent: July 9, 2013Assignee: Nxstage Medical, Inc.Inventors: James M. Brugger, Christopher McDowell
-
Patent number: 8475398Abstract: An extracorporeal blood processing method using a blood circuit comprising a pair of blood passages attached to opposite flow ends of a blood treatment device and said blood circuit is mounted on a blood pump console, the method includes: withdrawing blood from a vascular system of a human patient and drawing the blood into the blood circuit; pumping the withdrawn blood through one of the pair of blood passages using a first blood pump of the console and into the blood treatment device; pumping the treated blood from the treatment device through the other of the pair of blood passages using a second blood pump of the console; infusing the treated blood from the other blood passage and into the vascular system of the patient, and periodically reversing a flow direction of blood through the pair of blood passages and blood treatment device.Type: GrantFiled: November 6, 2009Date of Patent: July 2, 2013Assignee: Gambro uf Solutions, Inc.Inventor: John O'Mahony
-
Patent number: 8470180Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.Type: GrantFiled: August 3, 2012Date of Patent: June 25, 2013Assignee: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
-
Patent number: 8469916Abstract: Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection.Type: GrantFiled: February 28, 2011Date of Patent: June 25, 2013Assignee: Fenwal, Inc.Inventors: Christopher J. Wegener, Daniel R. Boggs, Kyungyoon Min, Prakash Mathew, Marc N. Weasler, Benjamin E. E. Kusters
-
Patent number: 8454548Abstract: A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.Type: GrantFiled: April 14, 2008Date of Patent: June 4, 2013Assignee: Haemonetics CorporationInventors: Toshiyasu Ohashi, Etienne Pagès, Dominique Uhlmann, Pascal Maillard, Michael Ragusa
-
Patent number: 8454549Abstract: A pumping system for assisting a patient's heart includes a blood pump disposed outside the patient's body and having an inlet and an outlet. An inlet cannula is configured for insertion percutaneously into the vascular system of the patient, and in fluid communication with the blood pump inlet to provide blood to the blood pump. An outlet perfusion cannula is configured for insertion percutaneously into the vascular system of the patient, and in fluid communication with the blood pump outlet to provide blood to the patient's vascular system. A control system is provided to control the blood pump and includes at least two control units for redundant control of the blood pump. Each control unit includes a watchdog for monitoring the control unit. A variation of the pumping system includes a bidirectional cannula for insertion percutaneously into the vascular system of the patient and to extend into the patient's heart.Type: GrantFiled: January 20, 2011Date of Patent: June 4, 2013Assignee: CardiacAssist, Inc.Inventors: Zafiris G. Zafirelis, John C. Marous, III, Yih-Choung Yu, Kirk A. Lehmann, Greg A. Johnson
-
Patent number: 8449488Abstract: A blood component collection apparatus comprises a blood component collecting circuit which includes an anticoagulant line for feeding an anticoagulant and a line for collecting an initial flow of collected blood. In the blood component collection apparatus, air is intermediately present between the anticoagulant and the blood in the passage of a blood collection needle side line, after a priming operation is performed in which anticoagulant is supplied from the anticoagulant line toward the side of a centrifugal separator in the blood collection needle side line through a branch connector and after an initial flow collecting operation is performed in which the initial flow of blood is collected.Type: GrantFiled: June 22, 2009Date of Patent: May 28, 2013Assignee: Terumo Kabushiki KaishaInventor: Makoto Hirabuki
-
Patent number: 8430832Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.Type: GrantFiled: June 30, 2010Date of Patent: April 30, 2013Assignees: The Regents of the University of Michigan, CytoPherx, Inc.Inventors: H. David Humes, Deborah Buffington
-
Patent number: 8430835Abstract: A renal therapy blood cleaning system includes: a blood filtering device in communication with an extracorporeal circuit; a first pump configured to pump fluid to the blood filtering device; a second pump configured to pump fluid from the blood filtering device; a balance chamber in fluid communication with first and second lines, the first and second lines in fluid communication with the first and second pumps, respectively, the balance chamber configured to exchange like volumes of fresh and spent fluid; a plurality of valves; and a control scheme programmed to operate the plurality of valves to enable spent fluid taken from the balancing chamber through one of the first and second lines to be recirculated to the balance chamber through the other of the first and second lines to compensate for a volume of fresh fluid delivered to the blood filtering device.Type: GrantFiled: June 4, 2010Date of Patent: April 30, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Thomas D. Kelly, Waleed M. El Sayyid
-
Patent number: 8430833Abstract: A device and a method for delivering fluids, preferably for delivering medical fluids, such as in the field of dialysis, include at least one pump designed as a displacement pump and at least one control unit that controls the operation of the pump. The pump is actuated by the control unit such that during a suction stroke in a first operating condition the pump takes in a volume exceeding a desired delivery volume for the purpose of discharging a desired delivery volume, and discharges portions of the volume taken in by performing a plurality of partial delivery strokes in the form of partial volumes which are smaller than the volume taken in.Type: GrantFiled: May 26, 2006Date of Patent: April 30, 2013Assignee: Fresenius Medical Care Deutschland GmbHInventors: Alfred Gagel, Peter Imhof
-
Publication number: 20130098838Abstract: The present invention relates to a method for priming a line for adding a medical solution, the line branching off a return line of an extracorporeal blood circuit, in particular a calcium line, a control device for controlling or regulating the method according to the present invention and a blood or plasma treatment apparatus with at least the control device according to the present invention. It further relates to a digital storage medium, a computer program product as well as a computer program.Type: ApplicationFiled: October 18, 2012Publication date: April 25, 2013Inventors: Josef Beden, Olaf Kessel-Deynet, Juergen Klewinghaus, Thomas Pusinelli, Pascal Werner
-
Patent number: 8426122Abstract: A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.Type: GrantFiled: September 28, 2011Date of Patent: April 23, 2013Assignee: Cellscape CorporationInventors: Bhairavi Parikh, Michael D. Brody, James Stone, Jonathan D. Halderman
-
Patent number: 8425445Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.Type: GrantFiled: June 30, 2010Date of Patent: April 23, 2013Assignees: The Regents of the University of Michigan, CytoPherx, Inc.Inventors: H. David Humes, Deborah Buffington
-
Patent number: 8425446Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.Type: GrantFiled: June 30, 2010Date of Patent: April 23, 2013Assignees: The Regents of the University of Michigan, CytoPherx, Inc.Inventors: H. David Humes, Deborah Buffington
-
Patent number: 8425447Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.Type: GrantFiled: August 23, 2012Date of Patent: April 23, 2013Assignees: The Regents of the University of Michigan, CytoPherx, Inc.Inventors: H. David Humes, Deborah Buffington
-
Patent number: 8425448Abstract: This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.Type: GrantFiled: January 30, 2007Date of Patent: April 23, 2013Assignee: Terumo BCT, Inc.Inventors: Thomas Felt, Peter Pihlstedt, Bruce Gibbs
-
Patent number: 8409125Abstract: A blood-collection system configured to permit selection of either collection and disposal of shed blood from a patient or collection and processing of shed blood for autologous transfusion back to the patient includes an automated blood-processing machine. The system may also include a blood-collection reservoir, a separation chamber, and a fluid conduit. The blood-collection reservoir may be engageable with the blood-processing machine so that the machine can identify and report the presence of blood in the reservoir. The separation chamber may also be engageable with the blood processing machine. The fluid conduit may be configured to selectively join the reservoir to the separation chamber by a quick-connect coupling.Type: GrantFiled: November 7, 2007Date of Patent: April 2, 2013Assignee: Haemonetics CorporationInventor: Alec D. Bobroff
-
Patent number: 8409126Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.Type: GrantFiled: June 30, 2010Date of Patent: April 2, 2013Assignees: The Regents of the University of Michigan, CytoPherx, Inc.Inventors: H. David Humes, Deborah Buffington
-
Publication number: 20130030345Abstract: The present invention relates to a method for detecting a permeability or patency of a section of an extracorporeal tube which is inserted in a tube pump, a detection device for executing a method according to the present invention, a medical treatment apparatus which comprises at least one detection device and/or is in signal transmission with it or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.Type: ApplicationFiled: July 27, 2012Publication date: January 31, 2013Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventors: Soeren Gronau, Joachim Manke
-
Patent number: 8361005Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.Type: GrantFiled: September 2, 2010Date of Patent: January 29, 2013Assignee: Biomet Biologics, LLCInventors: Douglas M. Arm, Michael Ponticiello, Surinder Mathur, Andrew G. Hood
-
Patent number: 8349254Abstract: A circuit for collecting a blood component includes a blood collection device provided with a blood collection needle through which blood is collected from a blood donor, a blood separator in which the blood collected by the above blood collection device is separated, a blood component collection bag in which a predetermined blood component separated by the above blood separator is collected, a blood line in which the blood collection needle is connected to an inlet of the blood separator, a line for removing an initial blood flow, which branches from a first branching portion formed in the blood line, and in which an initial flow of blood collected from the blood donor is removed, and an anticoagulant-injection line that branches from a second branching portion, formed in the line for removing the initial blood flow, and into which an anticoagulant is injected.Type: GrantFiled: July 4, 2006Date of Patent: January 8, 2013Assignee: Terumo Kabushiki KaishaInventors: Yoshiteru Hoshino, Yoshihiro Yokoo, Yuusuke Yamazaki
-
Patent number: 8337711Abstract: Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.Type: GrantFiled: February 27, 2009Date of Patent: December 25, 2012Assignee: Biomet Biologics, LLCInventors: Randel Dorian, Michael D. Leach, Richard W. Storrs, Jason Chavarria
-
Publication number: 20120323158Abstract: A method for extracorporeally administering selected biologic agents that target soluble cytokines and chemokines via immunoapheresis in order to treat patients with a variety of acute or chronic autoimmune and inflammatory disease states.Type: ApplicationFiled: March 10, 2011Publication date: December 20, 2012Inventor: Paul Tebbey
-
Patent number: 8334094Abstract: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.Type: GrantFiled: May 20, 2010Date of Patent: December 18, 2012Assignees: Cytosorbents, Inc.Inventors: James A Brady, James F Winchester, Vadim Davankov, Maria Tsyurupa, Ludmila Pavlova, Frank M Norris, Peter Quartararo, Jr., Jamie A Salsberg
-
Patent number: 8329388Abstract: Devices, systems, and methods reduce levels of proinflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among proinflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of proinflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among proinflammatory or anti-inflammatory stimulators or mediators.Type: GrantFiled: September 9, 2010Date of Patent: December 11, 2012Assignees: Cytosorbents, Inc.Inventors: James A Brady, James F Winchester, Vadim Davankov, Maria Tsvurupa, Ludmila Pavlova, Frank M Norris, Peter J Quartararo, Jr., Jamie A Salsberg
-
Patent number: RE44639Abstract: A hemodialysis and vascular access system comprises a subcutaneous composite PTFE silastic arteriovenous fistula having an indwelling silastic venous end which is inserted percutaneously into a vein and a PTFE arterial end which is anastomosed to an artery. Access to a blood stream within the system is gained by direct puncture of needle(s) into a needle receiving site having a tubular passage within a metal or plastic frame and a silicone upper surface through which needle(s) are inserted. In an alternate embodiment of the invention, percutaneous access to a blood stream may be gained by placing needles directly into the system (i.e. into the PTFE arterial end). The invention also proposes an additional embodiment having an arterialized indwelling venous catheter where blood flows from an artery through a tube and a port into an arterial reservoir and is returned to a vein via a port and a venous outlet tube distinct and distant from the area where the blood from the artery enters the arterial reservoir.Type: GrantFiled: January 15, 2010Date of Patent: December 10, 2013Assignee: Hemosphere, Inc.Inventor: Rafael P. Squitieri