Septum Patents (Class 604/88)
  • Patent number: 10966903
    Abstract: An adaptor for coupling with a medical container, including: a tubular body receiving a pierceable elastomeric piece, defining an inner cavity of the adaptor, the pierceable elastomeric piece being movable within the tubular body between a first position, in which a distal part of the pierceable elastomeric piece forms a seal of the cavity, and a second position, proximally spaced from the first position, in which the distal part opens the seal of the cavity, an air inlet, a filtering system for filling the inner cavity with decontaminated air, and a gripping member for securing the adaptor to the medical container. Also, an assembly comprising such an adaptor and a medical container.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: April 6, 2021
    Assignee: Becton Dickinson Holdings Pte. Ltd.
    Inventors: Laurent Barrelle, Anthony C. J. Fernando
  • Patent number: 10926036
    Abstract: One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially inserted into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 23, 2021
    Assignee: Credence Medsystems, Inc.
    Inventors: Alan E. Shluzas, Stephen H. Diaz, John F. Shanley, Jeff Tillack, Dan Thayer, Gary Steese-Bradley
  • Patent number: 10918796
    Abstract: A syringe for mixing two substances which have been retained separately inside the syringe is described, for instance in a storage condition. The syringe is used for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment, a syringe for retaining and mixing first and second substances comprises a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane, wherein the syringe is configured such that the membrane and the pointed member are axially slidable in relation to each other.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: February 16, 2021
    Assignee: Ferrosan Medical Devices A/S
    Inventors: Kristian Larsen, Lise Sjørup Elle, Thomas Ingemann Jensen
  • Patent number: 10912935
    Abstract: An access port for providing subcutaneous access to a patient is disclosed. In one embodiment, the port includes an internal body defining a fluid cavity that is accessible via a septum. A compliant outer cover including silicone is disposed about at least a portion of the body. A flange is included with the port body and is covered by the outer cover. The flange radially extends about a perimeter of the port body proximate the septum so as to impede penetration of a needle substantially into the outer cover in instances where the needle misses the septum. The flange can further include both an anchoring feature for securing the outer cover to the port body and an identification feature observable via x-ray imaging technology for conveying information indicative of at least one attribute of the access port. The outer cover provides a suitable surface for application of an antimicrobial/antithrombotic coating.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: February 9, 2021
    Assignee: Bard Peripheral Vascular, Inc.
    Inventors: Martha R. Wiley, Jodie L. Noyce, David M. Cise, William R. Barron, Kelly J. Christian, Amir Orome
  • Patent number: 10898117
    Abstract: A safety connector has a needle, and includes a tubular protective sleeve with a distal section, having a movable wall portion arranged in the peripheral wall thereof. The movable wall portion is selectively movable between a retracted position and a protection position. In the retracted position, the movable wall portion is aligned with the peripheral wall of the proximal section of the tubular protective sleeve. In the protection position, the movable wall portion projects into the inner space of the tubular protective sleeve.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: January 26, 2021
    Assignee: P2A MEDICAL
    Inventor: Alain Orlu
  • Patent number: 10869966
    Abstract: A syringe system, piston seal systems, stopper systems, and methods for assembling and using the syringe systems. The piston seal system including a piston seal member and a piston head member. The injection system including a container, a piston seal system positioned within the container, and a stopper system coupled to an end of the container. The method of assembling an injection system, the method includes obtaining a container, a piston seal system, and a stopper system. The method also includes inserting the piston seal system into a cavity within the container. The method further includes securing the stopper system at an end of the container in an opening of the cavity. Methods of using the syringe system, piston seal systems, and stopper systems are also disclosed.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: December 22, 2020
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Michael Cupicha, Alexei Goraltchouk, Ian Hart, Mike Stelmah
  • Patent number: 10864330
    Abstract: A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: December 15, 2020
    Assignee: CREDENCE MEDSYSTEMS, INC.
    Inventors: Gary Steese-Bradley, Stephen H. Diaz, Alan E. Shluzas, John F. Shanley, Jeff Tillack, Dan Thayer, John Merhige
  • Patent number: 10668473
    Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: June 2, 2020
    Assignee: Biolyph, LLC
    Inventors: Timothy Pearcy, James G. Skakoon
  • Patent number: 10603440
    Abstract: Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 31, 2020
    Assignee: INSULET CORPORATION
    Inventors: Maureen McCaffrey, David Nazzaro, Ian McLaughlin, Simon Kozin
  • Patent number: 10537675
    Abstract: A fluid delivery device includes: a fluid-filled cartridge comprising an outlet; a syringe comprising a substantially cylindrical syringe barrel having an open end and a fluid dispensing end; and a plunger rod configured to be received within the open end of the syringe barrel. The plunger rod comprises: a first end having a sealing member provided in sealing engagement with an inner wall of the syringe barrel such that a first syringe chamber is provided between the first end of the plunger rod and the fluid dispensing end of the syringe barrel; a second end extending out of the open end of the syringe barrel and having a cartridge-receiving chamber having a connection mechanism positioned therein for connecting the outlet of the cartridge thereto. The plunger rod also includes a fluid channel extending from the connection mechanism to the first end of the plunger rod.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: January 21, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Kevin P. Cowan
  • Patent number: 10500344
    Abstract: Injection systems with storage compartments to house various materials are described. The storage compartments facilitate provision of medical care in space- and time-efficient manners and are particularly useful in providing care in non-medical facilities.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: December 10, 2019
    Assignee: Hyprotek, Inc.
    Inventor: Patrick O. Tennican
  • Patent number: 10434256
    Abstract: A syringe includes a hollow body, a piston and a seal. The hollow body has a surrounding hollow body surface and forms a passage therein. An axis is formed in an axial longitudinal direction of the hollow body and the passage has a rear body opening and a front body opening arranged opposite to one another in the longitudinal direction. A first needle seat is formed at the front body opening, in which a needle cannula is arranged and relative to which the needle cannula is movable along the axis. The piston is arranged in the hollow body and is movable in the passage along the axis. The seal is able to be cancelled such that a receiving chamber and a supply space of the syringe are in flow communication in a release position.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: October 8, 2019
    Assignee: SULZER MIXPAC AG
    Inventors: Josef Ettlin, Marco Zünd
  • Patent number: 10406524
    Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: September 10, 2019
    Assignee: Biolyph, LLC
    Inventors: Timothy Pearcy, James G. Skakoon
  • Patent number: 10391262
    Abstract: A removable cap for use with an auto-injector device, whereupon removal of the cap triggers an actuating assembly that can cause an automatic mixing of medicament components in an auto-injector device and/or place the auto-injector in a state to be used.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: August 27, 2019
    Assignee: Windgap Medical, Inc.
    Inventors: Ashritha Durvasula, Mary Carter, Jeffrey Thomas Chagnon, Cole Constantineau, Chris Stepanian, Adam Standley, Brent Buchine
  • Patent number: 10207054
    Abstract: An injection device is provided with dual medicament chambers and a mixing pen needle assembly, whereby predetermined dosages of two medicaments can be provided to a mixing reservoir in the pen needle assembly and delivered simultaneously with the injection device.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: February 19, 2019
    Assignee: Becton, Dickinson and Company
    Inventor: Robert E. West
  • Patent number: 10195361
    Abstract: A portable auto-injector is capable of moving from a compact state where the auto-injector is in a shape easier to transport than in an activation state wherein the auto-injector has been extended. A safety limits movement of the needle assembly and prevents premature needle sticks. The drug is stored in one or more dry and wet medicament states until need.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: February 5, 2019
    Assignee: Windgap Medical, Inc.
    Inventors: Brent Buchine, Christopher Stepanian, Adam Standley
  • Patent number: 9630755
    Abstract: A dispenser is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials that may react upon exposure to air, such as glue. Means are provided in the dispenser to effect controlled delivery of a pre-determined amount of the substance contained in the dispenser. A one-way valve is provided to hermetically seal the portion of the dispenser containing the substance to be dispensed.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: April 25, 2017
    Assignee: MEDINSTILL DEVELOPMENT LLC
    Inventors: Daniel Py, Norbert M. Assion, Julian V. Chan
  • Patent number: 9517480
    Abstract: A bottle for the creation, storage, administration and dispensing of elemental iodine is disclosed. An amount of crystal iodine is safely housed at the bottom of the bottle. Water is poured into the bottle and contacts with the crystal iodine to form elemental iodine. With the crystal iodine safely secured at the bottom of the housing, the formed elemental iodine maintains contact with the crystal iodine to maintain its stability and extends is shelf life. Several dispensing device are also disclosed for dispensing or administering the elemental iodine, as needed, in order to treat internal and external areas of a human's or animal's body.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: December 13, 2016
    Inventor: Spyron J. Papageorge
  • Patent number: 9511122
    Abstract: The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: December 6, 2016
    Assignee: Ascendis Pharma Growth Disorders Division A/S
    Inventors: Grethe Nørskov Rasmussen, Susanne Kindermann, Harald Rau, Thomas Wegge
  • Patent number: 9352092
    Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament contained within a capsule having an integral flow distributor/distribution system and where both medicaments are delivered through a single hollow needle.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: May 31, 2016
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, John David Cross
  • Patent number: 9333147
    Abstract: A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: May 10, 2016
    Assignee: ARTE CORPORATION
    Inventors: Andreas Schuetz, Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Patent number: 9327082
    Abstract: A drug delivery system to deliver two or more medicaments operable through a auto-injector drug delivery device and a single dispense interface. The device comprises a housing defining a primary reservoir containing a first medicament. A dosing mechanism operably connected to the primary reservoir. A single dispense interface is configured for fluid communication with the primary reservoir and a secondary reservoir of medicament containing at least one drug agent configured for fluid communication to the single dispense interface. A single activation of the dosing mechanism causes medicament from the primary reservoir and a non-user settable dose of the second medicament to be expelled through the single dispense interface.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: May 3, 2016
    Assignee: Sanofi-Aventis Deutschland
    Inventors: Garen Kouyoumjian, Malcolm Stanley Boyd, Daniel Thomas De Sausmarez Lintell
  • Patent number: 9283148
    Abstract: A multi-purpose syringe that may be used both for gravity feeding and syringe pump assisted feeding of a neonate is disclosed. The multi-purpose syringe includes a cap and a plunger. The cap and plunger may be selectively engaged to the barrel depending on whether the neonate is fed by gravity or syringe pump. The cap seals the top of the barrel but allows gas to pass between the inside of the barrel and the environment and traps liquid within the barrel. To this end, the cap has an aperture covered by a hydrophobic member.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: March 15, 2016
    Assignee: MEDELA HOLDING AG
    Inventors: Dongchul D. Hyun, Michael T. Fleury
  • Patent number: 9237987
    Abstract: A metering device is used for the metered administration of a flowable preparation together with a flowable carrier medium. A storage container for the preparation has at least one access opening. A metering plunger body can be moved in a sealed manner in the storage container between a starting position and at least one metering position. The metering plunger body is hollow. A metering sleeve has on a bottom side an eccentric metering sleeve opening. An inner plunger body has on the bottom side an eccentrically arranged plunger body opening. In a through relative rotation position of the metering sleeve relative to the inner plunger body a passage is provided between the inside of the storage container and the inside of the inner plunger body. In a closed relative rotational position this passage is closed. This results in a user-friendly and compact metering device.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: January 19, 2016
    Assignee: RAUMEDIC AG
    Inventors: Thomas Jakob, Frank Skaper, Thorsten Kellner, Frank Richter
  • Patent number: 9227018
    Abstract: A prefilled syringe of a before-use mixing type not requiring a bypass portion defined by a recessed inner surface portion of an outer cylinder, including first and second gaskets (4,5) fitted in the outer cylinder (2), and non-rotatively and complementarily shaped engagement portions (12, 13) respectively at a front end of the first gasket (4) and a rear end of the second gasket (5) to reduce the period for transferring a liquid between two chambers separated by the gaskets. During storage, the engagement portions abut each other to be kept out of engagement with each other, whereby a drug containing space is defined between the gaskets. When a liquid is transferred from a space defined on a rear side of the first gasket (4) to the drug containing space, the internal pressure of the drug containing space is prevented from being excessively increased.
    Type: Grant
    Filed: April 14, 2013
    Date of Patent: January 5, 2016
    Assignees: Taisei Kako Co. Ltd., Suzuken Co., Ltd.
    Inventors: Yukihiro Ogawa, Ichiro Suzuki
  • Patent number: 9125995
    Abstract: A one-part reconstitution device is described, for temporarily separating two substances into two compartments within a cartridge or syringe and allowing for mixture of the two substances within the cartridge or syringe. In various embodiments, the one-part reconstitution device may include an outer, contact portion configured to contact an inner surface of the cartridge or syringe, and an inner, deflection portion positioned within the contact portion. The deflection portion may be movable from a locked position, in which the deflection portion causes the contact portion to exert a first radial force against the inner surface, to an unlocked position, in which the deflection portion causes the contact portion to exert a second radial force against the inner surface. The second radial force may be less than the first radial force, and the contact portion and the deflection portion may comprise one part.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: September 8, 2015
    Assignee: GlucaGo LLC
    Inventors: Rush L. Bartlett, II, Peter M. Greco, Jr., Barry J. Davignon
  • Patent number: 9089474
    Abstract: A vial access device includes a housing having first and second connectors. The first connector is configured to be secured to a first container and the second connector is configured to be secured to a second container. The vial access device further includes a spike member extending from the housing and having a proximal end and a distal end. The spike member defines a vent lumen and a fluid lumen spaced from the vent lumen with each of the vent lumen and the fluid lumen having a distal opening. A shape defined by a circumference of the spike member is only symmetric about one axis at a position between the proximal end of the spike member and the distal opening of the fluid lumen.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: July 28, 2015
    Assignee: Becton Dickinson and Company Ltd.
    Inventor: Alexander Cederschiöld
  • Patent number: 9055992
    Abstract: A carpule for a dental syringe provides an internal piston disposed between a front septum and a rear plunger. The internal piston is hollow and includes a thin membrane front. The internal piston is designed to offer minimum resistance to movement in the carpule body to allow for aspiration and for easy dispensing. The internal piston divides the carpule into two anesthetic chambers, allowing an anesthetic without a vasoconstrictor and an anesthetic with a vasoconstrictor to be dispensed sequentially in a single injection and without causing undue trauma to the patient.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 16, 2015
    Inventor: Bryan Larson
  • Patent number: 9044536
    Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: June 2, 2015
    Assignee: Becton, Dickinson and Company
    Inventors: Vincent J. Sullivan, Ge Jiang, Matthew S. Ferriter, Kenneth G. Powell, P. Spencer Kinsey, Carl R. Sahi, John M. Polidoro
  • Publication number: 20150100018
    Abstract: A prefilled syringe of a before-use mixing type is provided, which does not require a bypass portion defined by a recessed inner surface portion of an outer cylinder. In the prefilled syringe, a first gasket (4) and a second gasket (5) are fitted in the outer cylinder (2), and non-rotatively and complementarily shaped engagement portions (12), (13) are respectively provided at a front end of the first gasket (4) and a rear end of the second gasket (5) in order to reduce a liquid transfer period required for transferring a liquid between two chambers separated by the gaskets. During storage, the engagement portions (12), (13) abut against each other to be kept out of engagement with each other, whereby a drug containing space is defined between the gaskets (4), (5). When a liquid is transferred from a liquid containing space defined on a rear side of the first gasket (4) to the drug containing space, the internal pressure of the drug containing space is prevented from being excessively increased.
    Type: Application
    Filed: April 14, 2013
    Publication date: April 9, 2015
    Inventors: Yukihiro Ogawa, Ichiro Suzuki
  • Patent number: 8998880
    Abstract: A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: April 7, 2015
    Assignee: Duoject Medical Systems Inc.
    Inventors: David L. Reynolds, Daniel MacDonald, Roger McCarthy
  • Patent number: 8973749
    Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: March 10, 2015
    Assignee: Biolyph, L.L.C.
    Inventors: Timothy Pearcy, James G. Skakoon
  • Patent number: 8894608
    Abstract: A steroid delivery system including a mixing syringe having a first chamber and a second chamber and at least one hypodermic needle is provided. The first chamber of the mixing syringe contains a pre-measured volume of a local anesthetic and the second chamber contains a pre-measured volume of a corticosteroid. An improved mixing syringe and a method for treating pain using the steroid delivery system of the present invention is also provided herein. The improved syringe achieves mixing without the introduction or elimination of air and without puncturing or rupturing of a membrane, diaphragm or other material. The kit concept improves the speed of the procedure, sterility, accuracy of dosing, and immediate availability of disparate items to implement the procedure in a variety of medical practice settings.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: November 25, 2014
    Inventor: Michael P. Connair
  • Patent number: 8858485
    Abstract: The connector for a fluid line of an extracorporeal circuit comprises a tubular body which internally defines a fluid passage, a first connection port predisposed for coupling to the fluid line, a second connection port predisposed for coupling to a male Luer connector borne by an external element, and a closure element of the second connection port. The closure element is formed of a breakable membrane made in a single piece with the tubular body. On coupling, the membrane is broken by the truncoconical projection of the male Luer connector. The connector connects a service line of an extracorporeal circuit to a pressure sensor of a dialysis machine.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: October 14, 2014
    Assignee: Gambro Lundia AB
    Inventors: Roberto Neri, Andrea Paltrinieri
  • Patent number: 8833606
    Abstract: A device for mixing and applying a substance includes a syringe barrel, a plunger, a shaft, a mixing surface, and a locking device. The syringe barrel is preloaded with one or more components of the substance and is enclosed by a seal. The plunger has a plunger body that is displaceable within the syringe barrel, and a dispensing surface. The shaft within the plunger body has a first end and a second end, and is positioned to extend through and from the plunger body. The mixing surface is attached to the first end of the shaft. The locking device enables the mixing surface to alternate between an extended position and a retracted position. In the extended position, the mixing surface projects from the dispensing surface to promote mixing of the substance. In the retracted position, the mixing surface is retracted through the dispensing surface into the plunger body.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: September 16, 2014
    Assignee: Howmedica Osteonics Corporation
    Inventor: Marc Miller Graham
  • Publication number: 20140243741
    Abstract: An administration device comprises a container and a mixing device for mixing an active substance (in a first chamber) with a dilution liquid (in a second chamber). The container has a membrane seal at one end and is combined with a mixing device for mixing the active substance. The administration device has an injection needle unit with a distal needle portion facing away from the container for piercing the skin, and disposed opposite thereto is a proximal needle portion facing the membrane when the administration device is in the initial position, which is thrust through the membrane into the container in a mixing position. The administration device includes a protective sleeve arranged coaxially about the injection needle, movable from the initial position only in the proximal direction relative to the container. The protective sleeve can be non-rotatably connected to the container in the mixing position and rotated relative to the mixing device to perform mixing.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: TecPharma Licensing AG
    Inventors: Nadine Kaufmann, Jürg Hirschel, Markus Tschirren
  • Patent number: 8808233
    Abstract: A combining syringe wherein multiple fluids are dispensed through a primary plunger into a primary cylinder when a force is applied to the secondary plunger shaft. The fluids are combined and dispensed from the primary cylinder's attaching end when a force is applied to the primary plunger shaft. The primary plunger shaft has a primary plunger attaching end opposite a primary pressure applying end. The primary plunger is connected to the primary plunger attaching end. The primary plunger shaft accepts a secondary cylinder and secures it with an attaching element. The secondary cylinder has a secondary plunger receiving end opposite a dispensing end. The secondary cylinder's dispensing end is inserted into an opening of the primary plunger. The secondary plunger shaft has a secondary plunger attaching end opposite a secondary pressure applying end. The secondary plunger is connected to the secondary plunger attaching end.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: August 19, 2014
    Inventors: Laurie Ausley Nelson, Shirley Marie Spelich
  • Publication number: 20140221916
    Abstract: An injector (10) for injecting a medicament into a patient. The injector includes a container (18) defining a first chamber (22), which contains a fluid therein, and a second chamber (23). The injector also includes an injection conduit (126) configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source (62) is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.
    Type: Application
    Filed: April 4, 2014
    Publication date: August 7, 2014
    Applicant: ANTARES PHARMA, INC.
    Inventors: Thomas E. KRAMER, Peter L. SADOWSKI
  • Patent number: 8781545
    Abstract: Body monitoring device, having a surface and configured to be applied to and/or near the body, comprising at least one light source and at least one photo detector. The at least one light source emits light in at least a direction away from the surface. The at least one photo detector is configured to detect light that is emitted by the at least one light source and reflected by the body in a direction towards said surface.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: July 15, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Margreet De Kok, Liesbeth Van Pieterson, Martinus Bernardus Van Der Mark
  • Patent number: 8753310
    Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: June 17, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Vincent J. Sullivan, Ge Jiang, Matthew S. Ferriter, Kenneth G. Powell, P. Spencer Kinsey, Carl R. Sahi, John M. Polidoro
  • Patent number: 8708951
    Abstract: The invention relates to a single-use injector (4) and a dual-chamber system (99), wherein at least one first chamber (105) is part of a cylinder-piston unit (100) that can be received in the single-use injector, and wherein the second chamber (255) is part of a container (250) that can be at least temporarily closed by means of a stopper (257) and that is inserted in a container adapter (200) releaseably supported on the single-use injector. To this end, the plug comprises a plug hole. The container adapter comprises a transfer tube that is closed at first. When the container is inserted in the container adapter, the transfer tube (242) connects the interior of the cylinder-piston unit to the interior of the container.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: April 29, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Rudolf Matusch
  • Patent number: 8679073
    Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: March 25, 2014
    Assignee: DEKA Products Limited Partnership
    Inventor: Larry B. Gray
  • Patent number: 8636689
    Abstract: Pen injection devices (10) and methods of using a pen injection device are disclosed. Pen injection devices include a sterile dual transfer spike assembly (150) including a dual transfer spike defining a fluidic pathway; a first cartridge assembly (12) including a first cartridge (20) containing a first substance; a second cartridge assembly (14) including a second cartridge (30) containing a second substance; a plunger rod (50) translatable in a first direction; and a biasing mechanism (60) configured to bias the plunger rod in a second direction opposite the first direction. Methods of using a pen injection device having a first container, a second container, a plunger rod, and a biasing mechanism include activating the pen injection device, thereby creating a fluidic pathway between the first container and the second container; and translating the plunger rod at least once, thereby transferring a first substance from one container to the other container to mix with a second substance.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: January 28, 2014
    Assignees: Amylin Pharmaceuticals, LLC, Astrazeneca Pharmaceuticals LP
    Inventors: Reynaldo B. Halili, Jr., Victor Wei-Chung Chang, Phillip A. Estepa, Tyler J. Holschlag, Philip J. Simpson, David G. Matsuura
  • Patent number: 8568446
    Abstract: A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: October 29, 2013
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Takashi Kurokawa, Christopher W. Widenhouse, Agnieszka Seyda, Jeffrey S. Swayze, Foster B. Stulen, Mark H. Ransick, Richard W. Timm, Shailendra K. Parihar, Shelby L. Cook Kornbluth
  • Patent number: 8540691
    Abstract: A drug solution transferring device that can suppress dispersion of a toxic drug solution to a surrounding environment is provided. The drug solution transferring device includes a barrel provided with an opening, and a connection tool for connection to the barrel. The barrel includes an elastic member for closing the opening. The elastic member is formed of a plurality of membranes overlaid together. The membrane has a projection projecting into the barrel. The connection tool includes a first needle having a sharp tip end. The first needle has a liquid hole extending in an extending direction of the first needle. When the needle penetrates through the projection of the membrane, an inside and an outside of the barrel are in communication with each other through the liquid hole to allow transference of the drug solution between the barrel and the connection tool.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: September 24, 2013
    Assignee: Nipro Corporation
    Inventors: Mitsuru Hasegawa, Takeshi Ohguro
  • Patent number: 8523807
    Abstract: A transfer and mixing device which utilizes a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: September 3, 2013
    Assignee: Duoject Medical Systems Inc.
    Inventors: David L. Reynolds, Daniel MacDonald, Roger McCarthy
  • Patent number: 8517982
    Abstract: The invention provides a packaging and administering device for administering a hydro-alcoholic solution by passing through a mucous membrane, the device comprising a deformable container for receiving at least one first fraction of the solution, a base that is secured to the container, and an administering tube that is secured to the base and that is suitable for receiving at least one second fraction of the solution, and that includes a cap. The tube includes a chamber for containing the at least one second solution and that is defined by two membranes, and the cap is movable in translation between two extreme positions and includes a needle for coming to pierce the two membranes in one of the extreme positions.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: August 27, 2013
    Inventors: Philippe Perovitch, Marc Maury
  • Patent number: 8500681
    Abstract: The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection system comprising: an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; a housing defining a second cavity, the housing different than the injector; a first movable member between the first cavity and the second cavity, wherein the first movable member is configured to transfer a fluid from the second cavity to the first cavity; and wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: August 6, 2013
    Assignee: Valeritas, Inc.
    Inventors: Robert R. Gonnelli, David Lipson, Vasu Nishtala, Ciro Dimeglio
  • Patent number: 8475404
    Abstract: A device for mixing and transferring is described. The device comprises a housing having open ends, a container accessing member having at least one fluid conduit therethrough, the container accessing member extending generally outwardly from one end of the housing. The device comprises a fluid delivery device accessing member having at least one fluid conduit therethrough, the fluid delivery device accessing member extending generally outwardly from the other end of the housing having the container accessing member, the fluid delivery device accessing member and the container accessing member in fluid communication therewith.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: July 2, 2013
    Assignee: Yukon Medical, LLC
    Inventors: David L. Foshee, Theodore J. Mosler, Bryan J. Peters, Nicholas J. Jardine, Todd M. Korogi
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler