Means Broken, Cut, Pierced Or Torn To Permit Mixing Patents (Class 604/87)
  • Patent number: 10398843
    Abstract: The present disclosure relates to a vessel configured to apply pressure greater than ambient pressure and/or provide a reduced headspace to a sample, while subject to focused acoustic treatment. Such treatment may generally result in enhanced effects of sterilization and/or other processing than if the sample is otherwise treated under ambient conditions. The sample may be a medicament that is sterilized under pressure using focused acoustic energy, where the sterilized sample is subsequently delivered to a patient. A fluid delivery cartridge may include a vessel having a transfer end opposite a plunger end. The transfer end may include a sealed cover. A plunger may be movably disposed in the vessel to accommodate entry of a liquid via piercing of the sealed cover. Upon processing (e.g., sterilizing) of the sample with focused acoustic energy, the sample may be appropriately dispensed through the pierced sealed cover.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: September 3, 2019
    Assignee: Covaris, Inc.
    Inventors: James A. Laugharn, Jr., Carl Beckett, Ion A. Tsinteris
  • Patent number: 10207269
    Abstract: The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: February 19, 2019
    Assignee: California Institute of Technology
    Inventors: Rustem F. Ismagilov, Feng Shen, Liang Li, David Selck, Joe Baker, Espir Kahatt, Chris Da Costa
  • Patent number: 9974712
    Abstract: A liquid dispensing system for oral administration comprises a dispenser and cartridges from which medicine is dispensed. Each cartridge includes a hollow shell with a septum at one end, a piston at the other end, and the medicine in a cavity between the septum and the piston. The dispenser includes receiver in which a cartridge is received, a plunger that can slide relative to the receiver and that has a plunging head that can drive the piston, and a barrel in which the cartridge, receiver and plunger can be received, at least partly. Once a cartridge has been inserted into the receiver, the receiver and cartridge are inserted into the barrel and a piercing head ruptures the septum. The plunger is pushed to drive the piston and the medicine is dispensed by the piston, through a discharge passage of the barrel.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: May 22, 2018
    Inventors: Alexander Markus Oelz, Robert James Martin
  • Patent number: 9895288
    Abstract: A fluid transfer device includes a first portion having a first end and a second end. The first portion includes a first connector configured to be connected to a first container and including a cannula. The fluid transfer device includes a second portion having a first end and a second end. The second end of the first portion extends at least partially into the second end of the second portion. The second portion includes a second connector configured to be connected to a second container and a third connector spaced apart from the second connector. At least a portion of the first portion is axially and rotationally movable with respect to at least a portion of the second portion from a first position in which the first connector is aligned with the second connector to a second position in which the first connector is aligned with the third connector.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: February 20, 2018
    Assignee: Becton Dickinson and Company Limited
    Inventors: Emily Augustini, Anam Azimuddin, Katerina Kaczmarski, Sae Yong Jang, Jiwon Jung, Chen Wu
  • Patent number: 9889442
    Abstract: A reagent preparation and dispensing device includes a body having a reaction chamber for a reagent and a solution reservoir for a solution. The solution reservoir is isolated from the reaction chamber. A plunger is movably coupled with the body. Movement of the plunger from a starting position to a seated position pushes the solution into the reaction chamber. A dispensing path extends from the reaction chamber out of the body. The dispensing path is configured to dispense a reagent mixture formed from the solution and the reagent. A vent path extends from the reaction chamber, the vent path vents reaction chamber gas displaced by the addition of the solution to the reaction chamber throughout movement of the plunger from the starting position to the seated position.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: February 13, 2018
    Assignee: BIOLYPH, L.L.C.
    Inventors: Timothy Pearcy, James G. Skakoon
  • Patent number: 9592342
    Abstract: An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: March 14, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, David Martin Leak, Carmen Patricia Keating, David Sanders, Elizabeth Anne Marshall, Jay Graham, Ross Douglas Laurie MacArthur, Michael James Heald, Christopher James Smith, Elliot Lucas Ortiz
  • Patent number: 9220577
    Abstract: A hollow syringe barrel for use in syringe mixing systems for mixing a two-component composition. A hollow body of the syringe barrel includes a proximal end, a distal end, and continuous cylindrical wall defining an internal chamber for containing a first component. A rupturable membrane disposed at the distal end caps and seals off a single dispensing orifice. A second syringe barrel can be coupled to the distal end of the hollow syringe barrel to form a syringe-to-syringe mixing system. First and second plungers disposed within the hollow syringe barrel and second syringe barrel, respectively, are used to mix and cycle back and forth first and second components initially contained within the hollow syringe barrel and second syringe barrel. The two components are initially separated by the rupturable membrane, which is irreversibly ruptured by applying sufficient pressure to the first plunger within the hollow syringe barrel prior to mixing.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: December 29, 2015
    Assignee: Ultradent Products, Inc.
    Inventors: Neil T. Jessop, Bruce S. McLean, Jared Sheetz
  • Patent number: 9220844
    Abstract: A syringe comprising a cylinder and a plunger arranged in the latter has a sealing element which, with a contact region, abuts an inner wall of the cylinder and seals an annular gap between the plunger and an inner wall of the cylinder. The contact region has a front section which, in the rest state, abuts the inner wall of the cylinder with an abutment pressure. The plunger is connected to the sealing element in such a way that the sealing element does not follow an initial movement of the plunger out of the rest state and such that the sealing element follows a continued movement of the plunger. The abutment pressure between the sealing element and the inner wall in the front section of the contact region decreases during the initial movement. With the syringe, less force is required in order to overcome the static friction between the sealing element and the inner wall of the cylinder.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: December 29, 2015
    Assignee: Transcodent GmbH & Co. KG
    Inventor: Jochen Heinz
  • Patent number: 9182327
    Abstract: A flow control assembly for use in preparation of samples for analysis by solid phase extraction includes a housing assembly having a first passage communicating with a needle bore and locating a solid phase sorbent, a second fluid port, and a valve for selective aspiration or delivery of fluid across a solid phase sorbent, or bypassing the solid phase sorbent. Independent flow paths are provided for a sample via the needle, and of the elution solvent via a separate port. The valve includes relatively slideable first and second members, the second member including an elongate shank that is relatively reciprocably slideable for effecting selective aspiration or delivery of fluid between first and second relative positions. A third fluid port may be provided communicating with the elongate second passage for selective fluid communication with a port in a shank when the shank is at the second relative position.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: November 10, 2015
    Assignee: TRAJAN SCIENTIFIC AUSTRALIA PTY LTD
    Inventors: Ernest Frederick Dawes, Andrew Gooley
  • Patent number: 9125992
    Abstract: This disclosure relates to fluid delivery devices which include a body defining a fluid channel with filtration. In one embodiment, the body is molded to include a barrier which extends across the fluid channel and a series of apertures or openings are formed through the barrier. A laser device may be used to form the apertures through the barrier.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: September 8, 2015
    Inventor: Melvin A. Finke
  • Patent number: 9078808
    Abstract: A container supplies a medicinal formulation that includes a hydrophilic polymer and an active agent capable of bonding to the polymer. The container includes a first compartment for storing the polymer and a second compartment fluidly isolated from the first compartment for storing the active agent. A frangible barrier is shared between the compartments. A fluidic outlet is disposed on the container to dispense the medicinal formulation. Dispensing of the medicinal formulation includes rupturing the frangible barrier, mixing the polymer and active agent together to form the medicinal formulation, and administering the medicinal formulation provided from the fluidic outlet to a patient. The polymer can be PEG, while the active agent can be magnesium.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: July 14, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Toya D. Kimble, Jeffery C. Marx
  • Publication number: 20150112252
    Abstract: The invention provides a dispense interface for an ejection device comprising a first part and a second part, at least a first opening, a second opening and a third opening, a fluidic channel and a connection element for each of the openings, wherein the first part is joined to said second part to form at least a part of said fluidic channel connecting said openings with each other and wherein each connection element is configured to accept a needle assembly for a fluid tight connection with said corresponding opening in order to reduce the complexity and provide an easy usage of the dispense interface and at the same time overcome the problems of material compatibility and cross contamination. The invention also relates to a system comprising a dispense interface according to the invention and a needle assembly for each opening. Furthermore, the invention relates to a method for preparing a dispense interface according to the invention.
    Type: Application
    Filed: May 16, 2013
    Publication date: April 23, 2015
    Inventors: Ilona Eggert, Frederic Laugere, Cristian Popa, Ben Impey, Andrew Macleod
  • Publication number: 20150112253
    Abstract: The present application relates to a dispense interface comprising at least a first flat part tightly connected with a second flat part, wherein at least one of the at least two flat parts comprises at least one deepening configured for forming at least one part of a channel profile, wherein the at least one deepening is formed by embossing, wherein the channel profile comprises at least a first inlet channel and a second inlet channel and at least one outlet channel, wherein each of the at least two inlet channels is configured for fluid communication with a respective reservoir of at least two reservoirs.
    Type: Application
    Filed: May 16, 2013
    Publication date: April 23, 2015
    Inventors: Frederic Laugere, Cristian Popa, Ben Impey, Andrew MacLeod
  • Publication number: 20150094651
    Abstract: A delivery system for delivering a therapeutic agent to a patient includes a catheter, a stop feature, a container and a bar. The catheter has a proximal end and a distal end and includes a body defining a lumen that extends to the distal end of the catheter. The stop feature is in proximity to the distal end of the catheter. The container is configured to house the therapeutic agent and is insertable and slidably disposable in the lumen of the catheter. The container is also configured to engage the stop feature of the catheter. The bar is slidably disposable in the lumen of the catheter. Sliding of the bar distally in the lumen forces the therapeutic agent out of the container and out of the lumen when the container is engaged with the stop feature. The stop feature is configured to inhibit the container from exiting the lumen.
    Type: Application
    Filed: October 8, 2014
    Publication date: April 2, 2015
    Inventors: Prasanga Hiniduma-Lokuge, Daniel Sigg, Xiaohong Qiu
  • Patent number: 8974407
    Abstract: A syringe for dispensing anesthetic from a cartridge having an interior wall defining a hollow interior sized and shaped for receiving a dose of anesthetic, and a piston. The syringe includes a tubular plunger slidably received in the hollow interior of the tubular cartridge. The plunger has a hollow interior extending between a distal end shaped for engaging the piston and an open proximal end. The syringe includes a plunger rod slidably received in the hollow interior of the tubular plunger. The rod has a sharp distal end adapted to penetrate the piston, a proximal end, and a length extending between the distal end and the proximal end sized so a delivery portion of the rod extends through the piston into the cartridge when the rod is driven through the piston. The delivery portion includes a recess for receiving a buffering agent to reduce acidity of the dose of anesthetic.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: March 10, 2015
    Assignee: Covidien LP
    Inventor: Melvin Finke
  • Publication number: 20150065993
    Abstract: Described is a syringe housing at least one removable carpule containing at least two injectable solutions and having a mixing chamber for mixing two injectable solutions during administration of the solutions, and methods of using the syringe.
    Type: Application
    Filed: September 3, 2014
    Publication date: March 5, 2015
    Inventor: Max Arocha
  • Patent number: 8967374
    Abstract: A device and method are provided for storing medicaments and foods and/or beverages separately during shelf life, and for mixing the medicaments and foods and/or beverages when ready for use. A body of the device defines a plurality of first chambers for receiving a medicament, and a plurality of second chambers for receiving a food and/or beverage. A first sealing portion is located between the first and second chambers and is movable between a closed position preventing fluid communication between the chambers, and an open position permitting fluid communication between the first and second chambers for mixing the medicament and the food and/or beverage when ready for use.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: March 3, 2015
    Assignee: Dr. Py Institute LLC
    Inventor: Daniel Py
  • Publication number: 20150011975
    Abstract: A syringe assembly which has a barrel for containing one or more medicaments and a stopper disposed in the barrel defining and separating a first volume and a second volume within the syringe assembly. The stopper includes a permanent seal fluidly sealing the stopper to the barrel about the entire perimeter of the stopper intermediate the first volume and second volume, and a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the second volume and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable between a sealing configuration and an open configuration to selectively seal the channel from the first volume and is moveable from the sealing configuration to the open configuration upon fluid pressure in the first volume or second volume exceeding a first pressure threshold.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 8, 2015
    Applicant: Consort Medical PLC
    Inventors: Ian Anderson, Matt Ekman
  • Patent number: 8911395
    Abstract: A syringe carpule for storing, transporting and in situ mixing of a local anesthetic, such as lidocaine, and a buffer, such as sodium bicarbonate, and delivery of buffered anesthetic solution according to the present invention that comprises a hollow tubular body received within the frame of a carpule syringe, at least one axially movable plunger within the body and configured to be engaged and moved by a rod of the carpule syringe, a seal pierced by a rear portion of a needle coupled to the carpule syringe, a first chamber within the body filled with anesthetic solution during storing and transport, a second chamber defined within the body filled with buffering solution during storing and transport; and a breachable separating member between the first and second chamber configured to be removed for in situ mixing of the buffering and the anesthetic solutions allowing for delivery of a buffered anesthetic solution.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: December 16, 2014
    Inventor: George Just
  • Patent number: 8894609
    Abstract: A flexible bag (1) that is partially filled with a basic liquid solution (21) has a first end closure (3) from which a mixing tube (7) extends that is provided with a frangible closure cap (8) and a terminal (9) that is suitable for the connection of a container (22) of active substance (23) to be mixed with the basic liquid solution (21) and a second end closure (5) from which two dispensing tubes (12, 13) extend that are provided with respective frangible closure caps (14, 15). A first dispensing tube (12) has a terminal (18) of the press type and a second dispensing tube (13) has a terminal (19) of the screw type (FIG. 1).
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: November 25, 2014
    Assignee: Ditta Paola Giuseppe Gobbi Frattini
    Inventor: Paolo Giuseppe Gobbi Frattini
  • Patent number: 8852145
    Abstract: Inline liquid drug medical devices for use with a source of physiological fluid and a medicinal vessel for liquid drug reconstitution and administration purposes. The inline liquid drug medical devices include a housing having a longitudinal device axis, a rotary flow control member and a vial adapter for transposing the flow control member from an initial first flow control position for liquid drug reconstitution purposes to a second flow control position for liquid drug administration purposes. The inline liquid drug medical devices include a syringe port and a drug dispensing port co-axial with the device axis. The rotary flow control member is rotatable about an axis of rotation co-axial with the syringe port and the drug dispensing port.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: October 7, 2014
    Assignee: MEDIMOP Medical Projects, Ltd.
    Inventors: Igor Denenburg, Nimrod Lev, Moshe Gilboa
  • Publication number: 20140221918
    Abstract: A syringe for dispensing anesthetic from a cartridge having an interior wall defining a hollow interior sized and shaped for receiving a dose of anesthetic, and a piston. The syringe includes a tubular plunger slidably received in the hollow interior of the tubular cartridge. The plunger has a hollow interior extending between a distal end shaped for engaging the piston and an open proximal end. The syringe includes a plunger rod slidably received in the hollow interior of the tubular plunger. The rod has a sharp distal end adapted to penetrate the piston, a proximal end, and a length extending between the distal end and the proximal end sized so a delivery portion of the rod extends through the piston into the cartridge when the rod is driven through the piston. The delivery portion includes a recess for receiving a buffering agent to reduce acidity of the dose of anesthetic.
    Type: Application
    Filed: March 3, 2014
    Publication date: August 7, 2014
    Applicant: Covidien LP
    Inventor: Melvin Finke
  • Patent number: 8795226
    Abstract: A cannula assembly (10) comprising a hub (76) and a cannula (12) mounted in the hub (76). The cannula defines an inner space (36). The cannula comprises a distal end (16) and a proximal end (18). A first medicament (40) is provided in the inner space of the cannula. In one arrangement, the hub of the cannula assembly is configured to be coupled to an injection device (26). The cannula assembly may be removably or permanently coupled to the injection device containing a second medicament (17).
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: August 5, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Bernd Kuhn, Gerrit Hauck
  • Patent number: 8784372
    Abstract: The first aid pen having separate compartments is comprised of a pressure cap that can retract to expose a hypodermic needle suspended under and in fluid communication with a mixing chamber. The first aid pen includes a first compartment and a second compartment. The second compartment includes a membrane upon a top surface, which is punctured upon pushing a slideable member of the first compartment downwardly. Once the membrane is broken, the contents of the first compartment descends into and mix with the contents of the second compartment, and prior to intravenous or intramuscular injection via the hypodermic needle. The first compartment includes the slideable member, which is pushed downwardly in order to puncture the membrane and mix the two components stored in the respective compartment. The second compartment forms the mixing chamber when the contents of the first compartment descend therein.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: July 22, 2014
    Inventor: Johnathan D. Hoggatt
  • Patent number: 8753310
    Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: June 17, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Vincent J. Sullivan, Ge Jiang, Matthew S. Ferriter, Kenneth G. Powell, P. Spencer Kinsey, Carl R. Sahi, John M. Polidoro
  • Publication number: 20140148758
    Abstract: A device and kit are described for mixing and instillation of a two-part chemical system within a body cavity, under pressure. More particularly, a vaginal hygiene system is illustrated utilizing a two-part chemical system effective for achieving stasis of the vaginal flora, whereby bacterial vaginosis is effectively mitigated, thereby eliminating undesirable vaginal discharge and discomfort. In one embodiment a kit is described including a highly portable dispenser having separate and distinct reservoirs which segregate the two-part chemical system until the desired time of use, and further include a combination applicator nozzle and blending manifold, wherein activation of the device results in the fluidic coupling of the chemical reservoirs, and provides immediate intermixing of the two-part chemical system concomitant with pressurized expulsion through an imperforate nozzle into the vaginal canal.
    Type: Application
    Filed: December 26, 2013
    Publication date: May 29, 2014
    Applicant: JICL IP COMPANY, LLC
    Inventors: Jose I IPARRAGUIRRE, Craig LICHTBLAU
  • Patent number: 8728054
    Abstract: A syringe-carpule assembly comprising first and second carpules, a housing holding the first and second carpules in an end-to-end relationship, an outer hollow plunger rod supported by and slidable relative to the housing, and an inner hollow rod having first and second openings and being slidably arranged inside the outer hollow plunger rod. The inner hollow rod is slidable between first and second positions. The inner hollow rod in the first position has the first opening disposed within the first carpule and the second opening disposed within the second carpule. This allows liquid solvent in the second carpule to flow into the first carpule, which comprises an evacuated chamber containing solid matter that dissolves in the presence of that solvent to form a mixture. The second carpule is then removed and the mixture in the first carpule is injected into the patient.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: May 20, 2014
    Assignee: Synchrojet LLC
    Inventor: Steven Schulhof
  • Patent number: 8696619
    Abstract: A drug delivery device for delivering a drug to a preselected treatment site, includes a rupturable film capsule enclosing a quantity of the drug to be delivered; an array of micro-needles formed with passageways therethrough carried by the device; a covering layer overlying the capsule and forming a fluid-tight seal with the perimeter of the micro-needle array such that when the device is located with the micro-needles facing the treatment site, the application of pressure to the device causes the micro-needles to penetrate the treatment site and the capsule film to rupture to deliver the drug via the passageways to the treatment site; and an open mesh layer adjacent to the array of micro-needles effective, upon rupture of the capsule film, to uniformly distribute the drug to the micro-needles and also to reduce the possibility of clogging of the passageways.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: April 15, 2014
    Inventor: Robert P. Schnall
  • Publication number: 20140088486
    Abstract: Devices and methods are provided for drug delivery. The device may include a housing having a first compartment containing a drug in a dry, solid form, a second compartment containing a liquid carrier for the drug, and an expansion member located within or adjacent to the first or second compartment. The second compartment may be fluidly connectable to the first compartment by a rupturable barrier or mechanical valve. The device may also include an actuation system configured to expand the expansion member to rupture the rupturable barrier or open the mechanical valve and permit the liquid carrier to flow into the first compartment and mix with the drug to form a reconstituted drug solution.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 27, 2014
    Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
    Inventors: Scott A. Uhland, Felicia Linn, Michael I. Recht
  • Patent number: 8672878
    Abstract: A syringe for dispensing anesthetic from a cartridge having an interior wall defining a hollow interior sized and shaped for receiving a dose of anesthetic, and a piston. The syringe includes a tubular plunger slidably received in the hollow interior of the tubular cartridge. The plunger has a hollow interior extending between a distal end shaped for engaging the piston and an open proximal end. The syringe includes a plunger rod slidably received in the hollow interior of the tubular plunger. The rod has a sharp distal end adapted to penetrate the piston, a proximal end, and a length extending between the distal end and the proximal end sized so a delivery portion of the rod extends through the piston into the cartridge when the rod is driven through the piston. The delivery portion includes a recess for receiving a buffering agent to reduce acidity of the dose of anesthetic.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: March 18, 2014
    Assignee: Covidien LP
    Inventor: Melvin A. Finke
  • Publication number: 20140058319
    Abstract: Injection devices are disclosed for injections of substances. The disclosed devices separately may hold two separate substances, e.g., solid, liquid or gas substances, in separate compartments which are interrupted so that the separate substances come into contact during the activation of the device. One disclosed device includes a needle for injection and two substances that are mixed with only a few actions by the operator of the device. The device may or may not activate mixing by the removal of a sleeve which triggers compartment interaction through movement of pins, pegs, springs, wires, string, or other mechanisms which allow the materials held in separate chambers to come into contact with each other. Operator error during mixing and checking the dosage of substances to be injected is avoided with the disclosed devices. Also, the needle is maintained in a sterile state because the needle is held internally of the device until the sleeve is removed and the device begins to activate.
    Type: Application
    Filed: November 5, 2013
    Publication date: February 27, 2014
    Applicant: GLUCAGO LLC
    Inventors: Rush L. BARTLETT, II, Peter M. GRECO, Jr., Zachary R. GOSNELL, Jared L. WEST, Barry J. DAVIGNON, Arthur L. CHlEBOWSKI
  • Publication number: 20140039386
    Abstract: The present invention relates to safety delivery systems for intracameral administration of an appropriate dose of cefuroxime subsequent to cataract and other eye surgery. A preferred embodiment of an cefuroxime safety delivery system according to the invention comprises (a) a perforable sterile vial sterile-filled with a measured amount of cefuroxime, (b) a reconstitution syringe with a male luer fitting sterile-filled with 0.1 ml of isotonic salt solution per mg cefuroxime in the perforable vial and a vial adapter with a female luer fitting or one or more needles with female luer fitting, and (c) one or more sterilized delivery syringes with male luer fitting, each delivery syringe being capable of holding at least 0.1 ml of ejectable liquid and containing a marking indicating a fill volume of 0.1 ml of ejectable liquid.
    Type: Application
    Filed: February 14, 2012
    Publication date: February 6, 2014
    Applicant: CIS Pharma AG
    Inventor: Rolf Schäfer
  • Patent number: 8633016
    Abstract: A microbial detection assembly is disclosed which includes a tubular body, a pierceable septum, and a plunger. The tubular body defines a longitudinal axis and has a first end and a second end. The pierceable septum is configured to seal the first end of the tubular body. The plunger head is configured to substantially close the second end of the tubular body. Together, the plunger head, the pierceable septum, and the tubular body define a reservoir dimensioned to receive a medium and a sample substance. Additionally, the plunger head is positioned and is movable within the tubular body in response to changes in pressure within the reservoir.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: January 21, 2014
    Assignee: Covidien LP
    Inventor: Jonathan G. Parker
  • Publication number: 20140012191
    Abstract: A device and kit are described for mixing and instillation of a two-part chemical system within a body cavity, under pressure. More particularly, a vaginal hygiene system is illustrated utilizing a two-part chemical system effective for achieving stasis of the vaginal flora, whereby bacterial vaginosis is effectively mitigated, thereby eliminating undesirable vaginal discharge and discomfort. In one embodiment a kit is described including a highly portable dispenser having separate and distinct reservoirs which segregate the two-part chemical system until the desired time of use, and further include a combination applicator nozzle and blending manifold, wherein activation of the device results in the fluidic coupling of the chemical reservoirs, and provides immediate intermixing of the two-part chemical system concomitant with pressurized expulsion through an imperforate nozzle into the vaginal canal.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 9, 2014
    Applicant: JICL IP COMPANY, LLC
    Inventors: Jose I. IPARRAGUIRRE, Craig LICHTBLAU
  • Publication number: 20140005597
    Abstract: A preassembled kit organizes the administration of therapeutic botulinum toxin by providing all of the important ingredients necessary for the procedure, including a vial of botulinum toxin preserved on dry ice. The kit also includes saline solution sufficient to dilute the botulinum toxin; a syringe to inject the saline solution into the vial of botulinum toxin; one or more needles to administer the diluted botulinum toxin; and other items associated with the procedure. Such items may include a plurality of absorbent pads, a patient gown, and clinician gloves. Particularly for use in the administration of therapeutic botulinum toxin, the kit may further include at least one radiolucent electrode, and at least one needle adapted for connection to a nerve stimulator.
    Type: Application
    Filed: May 1, 2013
    Publication date: January 2, 2014
    Applicant: Compassion Physicians Associates, P.C.
    Inventor: David P. Jankowski
  • Publication number: 20140005598
    Abstract: The integrated puncture needle adapter is equipped with: a puncture needle; a needle hub; a tubular fixing part for fixing the needle hub; a tubular puncture needle accommodating part provided on a distal side of the tubular fixing part and having therein an accommodating space for accommodating the puncture needle; a second connecting part provided on a distal side of the puncture needle accommodating part; and a separable part which is formed between the tubular fixing part and the puncture needle accommodating part. A part on the distal side of the separable part is separable from a part on the proximal side of the separable part. The puncture needle is exposed when separated.
    Type: Application
    Filed: March 13, 2012
    Publication date: January 2, 2014
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventor: Hitoshi Okihara
  • Patent number: 8517982
    Abstract: The invention provides a packaging and administering device for administering a hydro-alcoholic solution by passing through a mucous membrane, the device comprising a deformable container for receiving at least one first fraction of the solution, a base that is secured to the container, and an administering tube that is secured to the base and that is suitable for receiving at least one second fraction of the solution, and that includes a cap. The tube includes a chamber for containing the at least one second solution and that is defined by two membranes, and the cap is movable in translation between two extreme positions and includes a needle for coming to pierce the two membranes in one of the extreme positions.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: August 27, 2013
    Inventors: Philippe Perovitch, Marc Maury
  • Patent number: 8486043
    Abstract: Described here are unit dose containers, methods, and kits for treating asthma and other pulmonary conditions by nebulization. The unit doses of active agents are provided in a low volume formulation, which results in faster nebulization of the unit doses. The containers are also formed to minimize internal surface area so that effective re-dispersion of the active agents can be achieved while reducing adsorption to the walls of the containers.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: July 16, 2013
    Assignee: MAP Pharmaceuticals, Inc.
    Inventors: Laxmi Iyer, Paul S. Uster
  • Patent number: 8469923
    Abstract: A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: June 25, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Lionel Vedrine, Roger W. Groskopf, Matthew Sweeney, Dnyanesh A. Talpade, Min Wei, Ruane Jeter
  • Patent number: 8454558
    Abstract: A hollow inner plunger for use within a syringe-in-syringe mixing system for mixing a two-part dental composition. The hollow inner plunger includes a body having a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a proximal end and a distal end. A sealing plug and rupturable membrane are disposed at the distal end of the body, and the sealing plug and rupturable membrane are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow inner plunger, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow inner plunger, and the hollow inner plunger is slidably disposed within the syringe barrel. The two components are initially separated by the rupturable membrane.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: June 4, 2013
    Assignee: Ultradent Products, Inc.
    Inventors: Neil Jessop, Bruce S. McLean, Jared Sheetz
  • Publication number: 20130110039
    Abstract: A syringe carpule for storing, transporting and in situ mixing of a local anesthetic, such as lidocaine, and a buffer, such as sodium bicarbonate, and delivery of buffered anesthetic solution according to the present invention that comprises a hollow tubular body received within the frame of a carpule syringe, at least one axially movable plunger within the body and configured to be engaged and moved by a rod of the carpule syringe, a seal pierced by a rear portion of a needle coupled to the carpule syringe, a first chamber within the body filled with anesthetic solution during storing and transport, a second chamber defined within the body filled with buffering solution during storing and transport; and a breachable separating member between the first and second chamber configured to be removed for in situ mixing of the buffering and the anesthetic solutions allowing for delivery of a buffered anesthetic solution.
    Type: Application
    Filed: November 1, 2012
    Publication date: May 2, 2013
    Inventor: George Just
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8403923
    Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 26, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Steven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza
  • Patent number: 8394052
    Abstract: A plunger-barrel apparatus is adapted for use within a syringe-in-syringe mixing system for mixing a two-part composition (e.g., a dental composition). A hollow plunger-barrel body has a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a plunger receiving end and a dispensing end. An integral sealing plug and rupturable membrane is disposed at the dispensing end of the body and include a sealing plug portion and a rupturable membrane portion that are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow plunger-barrel body as described above adapted to contain a first component, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow plunger-barrel body, and the plunger-barrel body is slidably disposed within the syringe barrel.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: March 12, 2013
    Assignee: Ultradent Products, Inc.
    Inventors: Neil Jessop, Bruce S. McLean, Jared Sheetz
  • Patent number: 8382704
    Abstract: A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movemen
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: February 26, 2013
    Assignee: Medrad, Inc.
    Inventors: Arthur E. Uber, III, David M. Griffiths, David M. Reilly, Alan D. Hirschman, Kevin P. Cowan, Mark Trocki
  • Patent number: 8382737
    Abstract: Disclosed is a dispensing system a dispenser having a first chamber containing a first material and a second chamber containing a second material. The dispenser is configured to selectively retract one of the chambers at least partially within the other to transition the dispenser between an extended position and a compact position. The first chamber includes an open top end that is, before use, covered with a first breakable membrane. A breaker ring, at least initially covered with a second breakable membrane, is configured to break the breakable membranes when the dispenser is transitioned between an extended position and a compact position. In the compact position, with the membranes broken, the first material and second material are free to form a mixture that can be dispensed via an opening in the dispenser's openable tip.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: February 26, 2013
    Inventors: Rourke M. Yeakley, Charles Leslie Floyd
  • Publication number: 20130030412
    Abstract: A method and device for mixing substances to form a mixture that can he administered to a patient are disclosed. Such a device can include a hollow cylindrical member, a barrier sealing an opening of the member, and a tether attached to the barrier so that the harrier at least partially ruptures when the tether is pulled in a direction away from the barrier. Such a method for mixing substances can include providing a device with a first substance contained within the hollow cylindrical member. The method can also include the step of inserting the device into the barrel of an administering system, where the administering system includes a second substance, and the step of pulling the component in a direction away from the barrier such that the tether causes the barrier to at least partially rupture.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 31, 2013
    Applicant: GLUCAGO LLC
    Inventor: Glucago LLC
  • Patent number: 8357147
    Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 22, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Brian D. Burkinshaw, John L. Wheeler, James B. Rogan, Steven I. Whitlock
  • Patent number: 8353866
    Abstract: The present invention relates to a mixing syringe device for delivering a medicament or medical composition to a site of interest. The mixing syringe device generally includes a multi-chambered open lumen and optionally a sectioned plunger. The open lumen has at least two longitudinally oriented chambers within the interior of the lumen, and the optional sectioned plunger has at least two longitudinally oriented extensions corresponding in configuration to the at least two longitudinally oriented chambers of the open lumen and configured to be reciprocatably disposed in the chambers of the open lumen. Each compartment of the lumen is configured to store a medicament component or medical composition component in its interior. In certain embodiments, each compartment is sealed at one end by a movable stopper mechanism and sealed at the other end by a sealing mechanism capable of temporarily or otherwise opening. Methods of use are also provided.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: January 15, 2013
    Assignee: Thomasevans, LLC
    Inventor: Richard T. Evans, Jr.
  • Publication number: 20120323172
    Abstract: Inline liquid drug medical device having a longitudinal device axis, a housing with a linear displaceable sliding flow control member displaceable along a transverse bore from a first flow control position for establishing flow communication between a first pair of ports for liquid drug reconstitution purposes to a second flow control position for establishing flow communication between a second pair of ports for liquid drug administration purposes, and a manually operated actuating mechanism for applying a linear displacement force for urging the flow control member to slide along the bore from its first flow control position to its second flow control position.
    Type: Application
    Filed: November 4, 2010
    Publication date: December 20, 2012
    Applicant: MEDIMOP Medical Projects Ltd.
    Inventors: Nimrod Lev, Igor Denenburg, Moshe Gilboa