Abstract: The device comprises a tubular housing with two jackets and a container filled with the liquid component of a drug. Within the inner jacket of the housing, close to the closed end thereof, is a chamber containing the powdered components of a drug. A needle for piercing the stopper which closes the container enables the interior of the container to be put in communication with the chamber so as to allow the liquid component to flow out and consequently mix with the powdered component. The subsequent advance of the container into the housing, with the consequent penetration of the piston into the container, causes the further flow of the liquid component into the chamber carrying the drug solution to the exterior of the device generally like a syringe. Its use as a supplier of infusions is also foreseen.

Abstract: A safety needle assembly is provided for locking a hypodermic syringe to a fitting of an intravenous set. The assembly includes a shield with a needle cannula mounted therein. A latch is pivotably mounted to the needle shield for rotation about an axis extending generally orthogonal to the needle cannula. The latch includes a locking flange having a slot for engagement with the fitting of the intravenous set. The latch can be lockingly engaged into a position for securely retaining the safety needle assembly to the fitting, and includes a resiliently deflectable finger for urging the latch into a fully opened condition in response to disengagement of the lock.

Abstract: In a plug-type connector having two plug parts for producing and interrupting a flow connection, in order to enable sealing of the flow branches of the respective parts when separated from one another when the flow connection is interrupted, each plug part is terminated with a perforable septum with a cannula held so as to be longitudinally displaceable in one septum. The cannula and the septa are fashioned with reference to one another such that the septum holding the cannula offers lower resistance to the cannula upon penetration than does the other septum. This results in the cannula first penetrating the septum that holds it when the plug parts are joined and subsequently penetrating the other septum. When releasing the plug parts from one another, the cannula is first withdrawn from the septum that holds it and is then withdrawn from the other septum.

Abstract: A medication dispensing device for implantation into an animal or human body, comprises a plurality of compartments each containing a dose of medicine to be dispensed and having a delivery opening permitting delivery of the medicine; a rupturable membrane sealing the delivery opening of each compartment, the membrane having a predetermined elastic deformation limit and a predetermined rupture point; and a membrane rupturing system associated with each compartment for rupturing the membrane thereof in response to an electrical signal.

Abstract: A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When a flexible extension of the piston is coupled with a tubular plunger, and an adaptor cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston may have an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded.

Abstract: An infusion unit has a flexible container and an open-ended pipe having a first opening in communication with the container and a second opening axially opposite the first. The pipe has smaller and larger diameter portions with the smaller diameter portion located between the second opening and the larger diameter portion. An axially moveable plug is receivable within the smaller diameter portion to seal the second opening of the pipe. An axially moveable engaging member with an end for engaging the plug and a needle at the opposite end for piercing the stopper of a vial. The plug may be pushed by the engaging member from the smaller diameter section to the larger diameter section so as to permit flow through the pipe between the first and second openings to the vial and container.

Abstract: A disposable two-component safety syringe with retractable injection needle adapted for the separate storage of medicament and medicament solvent and the pre-injection mixing thereof. The cartridge-type syringe is adapted to be used manually or in conjunction with an automatic injection/aspiration device for breaching a temporary seal between chambers for the medicament and medicament solvent immediately prior to injection are also provided. Pre-measured medicament is provided in a form which requires no pre-injection agitation. The cartridge is also provided with an injection needle disposed completely within the cartridge housing for safely and sanitarily withdrawing the injection needle to reside completely within the disposable cartridge after use. In one embodiment of the invention, a pushrod for automatically agitating the mixing components is provided.

Abstract: A drug delivery device is provided comprising a cartridge body including an upper portion defining a vial receiving area and terminating in a wall, the cartridge body including a cannula extending from the wall. A vial including a beneficial agent is coupled by a retaining member to the cartridge body in an inactivated position. The retaining member allows the vial to move to an activated position. The retaining member including an outer member and an inner member, the inner member separating from portions of the outer member as the vial moves from the inactivated position to the activated position.

Abstract: A transfusion device comprising a flexible vessel containing a solvent fluid, a plugged drug container containing a drug, and a communicating portion for communicating the vessel and the container with each other, the communicating portion comprising a communicating passage disposed at a top portion of the flexible vessel and having the drug container partially or wholly fitted therein, a plugged mouth portion of the container facing downward, a membrane disposed in the communicating passage for closing the passage, and a particular puncturing needle unit mounted in the communicating passage for enabling the vessel and container to communicate with each other. When the puncturing needle unit is pressed externally through the flexible vessel, the needle breaks the membrane and the plug member of the drug container to enable the vessel and container to communicate with each other.

Abstract: A drug vessel suitable for aseptic mixing of a drug with a solvent or diluent and for parenteral administration of the resultant solution, which includes a cylindrical vessel body reduced in diameter at both sides thereof to form a narrow mouth portion at each end, and a seal member to be attached to each mouth portion of the vessel body for sealing the same.

Abstract: A fluid container comprises a drug container, a deformable solvent container, a double-pointed hollow needle having a sharp piercing edge at each end and being arranged between the drug container and the solvent container, a guide capsule with a cap rotatably mounted thereon, and a means for converting rotary motion of the cap to a linear motion of the drug container to push the drug container toward the solvent container in cooperation with the cap and the guide capsule so that a fluid communication is made between two containers through the needle.

Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.

Abstract: A cartridge assembly for holding a lyophilized product, forming a disposable portion of a pen injector includes a cylindrical glass cartridge adapted to receive the product, a closure cap, a cartridge case, and a plunger mechanism. The closure cap is adapted to retain an elastomeric disc seal during lyophilization and includes diametrically opposed ledges. The closure cap and seal are adapted to cover a neck portion of the ampule, the neck portion having on its end a radially extending circumferential flange. The ledges of the closure cap and the flange of the neck portion allow the closure cap to remain open during lyophilization, oxygen purge and nitrogen overlay. An oval-shaped indentation formed on the inside of the closure cap aids in snapping the closure cap about the flange without crimping to retain the closure cap underneath the flange.

Abstract: An improved endotracheal tube and an adapter for a standard endotracheal tube allow the performance of various medical procedures while maintaining continuity of respiration and protecting the care-provider from contact with potentially hazardous body fluids. The adapter comprises a rigid plastic Y-tube having a very large bore stopcock in one arm. In a preferred embodiment the endotracheal tube adapter further comprises a puncturable, resealing membrane having a first face in fluid communication with the interior of the adapter and a second face accessible to the exterior of the adapter. The adapter may additionally include an inflatable cuff circumferentially disposed within a bore of one of the tubes so as to allow axial engagement of a cylindrical object disposed within the bore of the tube. A single unit endotracheal tube assembly comprising the adapter and a conventional endotracheal tube is also disclosed.

Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely contolled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.

Abstract: A transfusion device comprising a flexible vessel containing a solvent fluid, a drug container containing a drug, and a communicating portion for communicating the vessel and the container with each other, the commuicating portion comprising first and second passages adapted to communicate with the vessel and container and held in engagement with each other, a membrane and a plug member which are provided for closing the two communicating passages, and a particular cap held in thread engagement with the second communicating passage for enabling the two passages to communicate with each other.When the vessel and the container are rotated relative to each other, the cap slides to disengage the plug member of the second communicating passage and break the membrane of the first communicating passage, thereby allowing the vessel and the container to communicate with each other.

Abstract: A syringe for sequentially injecting a plurality of liquids into an intravenous (IV) infusion component that has a connector fitting includes a syringe vessel having a preferably needleless injection port that is engageable with the connector fitting of the IV component. A syringe plunger is slidably disposed in the syringe vessel, and at least one barrier plunger is slidably disposed in the syringe vessel between the injection port and the syringe plunger. The barrier plunger is formed with a pathway for fluid communication therethrough, and a valve is positioned in the pathway of the barrier plunger to block fluid communication through the pathway. A nipple extends inwardly from the injection port for opening the valve of the barrier plunger when the barrier plunger is urged against the nipple. A first liquid is disposed in the syringe vessel between the barrier plunger and the injection port and a second liquid is disposed in the syringe vessel between the two plungers.

Abstract: A multiple pharmaceutical syringe (160), especially useful for use in dispensing insulin, includes a body (162) housing first and second pharmaceutical-filled cartridges (182, 184). The cartridges are of the type with a septum (190) at one end and a piston (224, 225) at the other end with the liquid pharmaceutical (226, 228) between the two. The body also defines an accumulator chamber (202) within which an accumulator piston (238) is slidably mounted. When the cartridges are mounted within the body, the septums are pierced by hollow spikes (188) which are connected to a flow path opening into the accumulator chamber. Check valves (230) are used at the distal ends of the spikes to prevent liquid flow back into the cartridges. Pressing on the cartridge pistons forces the liquids into the accumulator chamber. Once the desired amounts of both liquids are in the accumulator chamber, the needle assembly is mounted to the replaceable fluid path assembly which fluidly couples the needle to the accumulator chamber.

Abstract: An injection set with a slit septum held in place in the inlet of a housing by a cap affixed to the inlet. A concave end of the septum is exposed through an aperture in the cap, and a peripheral flange portion of the septum is squeezed between the housing inlet and the cap, causing the septum's concave end to bulge and flatten, thus improving the sealing of the septum's slit. Extending through the septum slit is a drug transfer spike having a ball-shaped tip sharp enough to penetrate the diaphragm of a drug vial but not so sharp as to puncture the skin of a user.

Abstract: A method for treating mastitis which comprises the use of an infusion of an effective amount of (mon)oxychlorosene or sodium oxychlorosene in an aqueous carrier is disclosed.A mastitis treatment infusion applicator which comprises a body portion including a compartment containing a first material which is an aqueous carrier, a cap portion including a compartment containing a second material which is (mon)oxychlorosene or sodium oxychlorosene, a seal arranged on either the body or cap portion to separate the two compartments, and seal-breaking means arranged on either the cap or body portion respectively, wherein the cap and body portion are movable relative to one another between a first position in which the seal is intact and a second position in which the seal is broken and in which the materials in the two compartments may come into contact, at least the surfaces contacting the second material being fluorinated is also disclosed.

Abstract: A method of preparing autologous plasma fibrin perioperatively to induce local hemostasis is disclosed. The autologous plasma fibrin is thereafter simultaneously expelled onto a treatment site along with a physiologically acceptable thrombin solution to effect hemostasis at the site. An apparatus for simultaneously expelling the contents of vessels which separately contain the autologous plasma fibrin and thrombin solutions, respectively, is also disclosed. A kit for obtaining a sample of blood, extracting plasma fibrin therefrom, as well as all necessary syringes, needles, reagents, and the inventive apparatus is also disclosed.

Abstract: A suction drainage control system wherein waste-treating material is released into a sealed chamber. The chamber comprises of a cover with a flexible liner sealed to and suspended therefrom. A normally closed reservoir is provided on an underside of the cover for storing the waste-treating material therewithin as long as the reservoir remains closed. An externally operated actuator is provided on the cover for opening the reservoir to release the waste-treating material into the sealed chamber.

Abstract: A disposable syringe of a dual-chamber type, wherein an injection needle is secured to the tip end of an injection cylinder with a first component being filled in it, and the injection cylinder is accommodated for its free sliding operation within a cylindrical housing, a second component container is air tightly secured to the tip end of the housing through a seal member through which a penetrating operation can be effected, and a cover for air tightly covering the injection cylinder rear end portion, including a plunger which is inserted for its free sliding operation into the injection cylinder in cooperation with the housing is engaged with the rear end of the housing.

Abstract: A drug storage and delivery system that includes a drug containing vial assembly, a syringe assembly, and an adapter assembly for attaching the vial assembly to the adapter assembly. The vial assembly includes a vial that is provided with a pierceable stopper and a skirt member that circumscribes the outside of the vial. The syringe assembly includes a cannula extending longitudinally therethrough. The adapter assembly attaches the vial assembly to the syringe assembly in a manner that permits communication between the interior of the vial and the cannula extending through the syringe. The system also permits attachment of the syringe assembly to a container filled with a diluent and means for delivering the diluent into the vial assembly and subsequently directing the mixed solution back into the container.

Abstract: The present invention provides a sheath for at least removably covering the blunt end of the cannula. The sheath allows the cannula to be presterilized and utilized without subsequent sterilization. The sheath comprises a body member defining an interior for receiving at least a portion of the blunt cannula, the body member including a first end and a second end, the second end having an opening for receiving at least a portion of the cannula. The first end including a wall member so constructed and arranged as to rip upon the exertion of a sufficient perpendicular force by an end of the blunt cannula. The body also includes side walls extending between the first and second end, the side walls are so constructed and arranged so as to slide back along the cannula toward the second end upon the tearing of the first end by the cannula and the application of a sufficient force upon the side walls.

Abstract: A medical device which presents the backflow of fluid therethrough is particularly useful as a bloodless catheter assembly, that is, prevents the backflow of blood through the catheter by utilization of a self-closing valve carried in a hollow catheter housing to one end of which a catheter is fixed so as to provide a fluid passage through the catheter and catheter housing. The fluid passage in the catheter housing is sealed by a self-sealing valve element extending transversely across the passage upstream from the catheter. A hollow needle is held in the catheter housing downstream of and pointed at the valve element. Attachment of a fluid dispensing medical appliance to the other catheter housing end forces the valve element downstream onto the needle so as to pierce the valve element and open a fluid passage from the catheter housing upstream of the valve element through the hollow needle to the catheter.

Abstract: A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When a flexible extension of the piston is coupled with a tubular plunger, and an adaptor cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston may have an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded.

Abstract: The syringe of the invention segregates various fluids or solutions within separate compartments of its barrel, to be delivered in a specific sequence as they are expelled from the delivery tip by actuation of its plunger. A plurality of stoppers are incorporated within the barrel, with all but the one adjacent to the plunger includng a piercing device to penetrate each following stopper in sequence. The length of the piercing shaft of each such device is selected sufficient to pierce the stopper advancing towards it, yet not so long as to reach the piercing shaft of that advancing stopper.

Abstract: An automatic injector is provided having at least two chambers containing different ingredients of a medicament separated by an impermeable membrane. A lance is movable independently of a plunger to cut or pierce the membrane before a spring-loaded drive member for the plunger is released to drive a needle out of the body of the injector and discharge the medicament through the needle. A removable safety clip is provided for preventing movement of an actuating cap into an operative position for advancing the lance, and release of the drive member is preventable by a removable safety pin until the injector is to be used.

Abstract: An apparatus and method for mixing parenteral nutrition solutions from additives in a plurality of vials containing the additives, in which a vented spike is inserted through a disposable rack and into the stoppered end of each vial, with the vials secured on the rack. The rack is engaged on a stand through a quick release fitting, and maintains the vials in a vertical orientation with the labels clearly visible. A dedicated syringe is connected with each vial in aligned relationship therewith through a unique two-way valve which is mounted to a manifold. In one form of the invention, the valve is attached directly on the manifold to reduce dead space volume and consequently reduce residual fluid in the system between purges. A flushing system is attached to one end of the manifold to flush any residual fluids into the final container at the end of a transfer process.

Abstract: A syringe for the gravity-feed intravenous administration of drugs and the like comprises three hollow, elongated, cylindrical, outer, middle and inner barrels nested concentrically and tandemly within each other and means for suspending the syringe above a patient. The middle barrel has an open end with a rubber stopper on it slidably and sealingly disposed within the outer barrel to adjustably define a liquid-receiving volume therein. The inner barrel has a hollow interior, an open external end containing a microbial filter through which its interior is vented to ambient pressure, and a closed end having a sharp, hollow needle communicating with the interior and extending outwardly therefrom. Selective advancement of the inner barrel toward the rubber stopper causes the needle to penetrate the stopper and vent the volume to ambient pressure through the interior of the inner barrel and the filter, whereby liquid medication in the volume may gravity-feed through an established primary or secondary I.V.

Abstract: Syringe mixer and injector device formed of an injector and an adaptor having opposed interconnectable nozzles, e.g. with mating luer lock connectors, on their facing ends and sockets in their remote ends. Each of the injector and adapter has a protected fluid pathway flow connecting its nozzle and socket, a guideway to receive at its remote end for movement thereon a medicament vial when the vial stopper is connected to its socket, and a recessed short tubular spike forming the pathway portion in its socket and protruding into the socket and terminating inwardly from its remote end sufficiently to protect the spike from unintended human contact and arranged to penetrate the stopper thereat to flow connect its vial with its pathway in protected condition. After charging the injector connected vial with the contents of the adapter connected vial, e.g.

Abstract: A package comprising a package container structure having an open end leading into an interior chamber therein, a package lid structure mounted over the open end of the package container structure in generally sealed relation with the interior chamber thereof so as to be moved into opening relation thereto, and a device for use with a medicament vial disposed within the sealed interior chamber. The device and package container structure have interengageable elements disposed out of interengagement when the device is disposed within the sealed interior chamber operable when the package lid structure is moved into opening relation and the device is moved out of the open end of the interior chamber to be moved into interengagement. The device and package container structure with the interengaging elements thereof interengaged provide a generally sealed interior space including the interior chamber within which a medicament vial is contained in cooperating relation with the device.

Abstract: A spear-like device for puncturing the membrane or diaphragm stopper of a liquid medicament vial. The spear-like device includes a fluid supply port from which liquid can be delivered to a hooded needle.

Abstract: Disclosed is a fluid container having a flexible bag containing a diluent and having a closing film at its upper end, a capsule connected to the flexible bag, a drug container held in the capsule and a communicating member for communicating the flexible bag with the drug container. The communicating member has a double-edged hollow needle having a hub in the midway thereof, and a controlling mechanism for controlling the order of communication in such a manner that the plug of the drug container is stuck with one edge of the needle and thereafter the closing film of the flexible bag is stuck with the other end of the needle. The mixing procedure is sure and simple, and can be carried out in a short period of time.

Abstract: A disposable assembly comprises a drug container (2) having at one end an opening which is surrounded by an outwardly directed flange (7). A connector (1) has a sleeve (13) which is closed (14) at one end and open at its opposite end to receive the flanged end of the drug container as a plunger. Positioning means (18,19) provided within the sleeve and cooperating with the flange define an inserted and a retracted position of said sleeve relative to the flanged end of the drug container. A piercing member (15) provided at the closed end of the sleeve is directed towards the open sleeve end. A connecting member (16) provided at the closed sleeve end is directed opposite to said piercing member (15) and communicating therewith by means of a through passage (17).

Abstract: Disclosed is a dispenser for separately dispensing each of two biological fluids contained therein for intermixing at a site outside of the dispenser to produce hemostasis or a tissue adhesive. The dispenser is compact, contains internal reservoirs of the two bioloical fluids, and is designed for efficient reloading with filled nonsterile containers without compromising the integrity of the sterile field. The dispenser is capable of dispensing the biological fluids, such as fibrinogen and thrombin, at either a focused point of in an aerosol mist. In addition, spray elements are disclosed for uniformly distributing the two biological fluids along either the interior surface or the exterior surface of an implantable vascular graft.

Abstract: A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When the piston is coupled with a plunger, and an adapter cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston has an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded.

Abstract: A syringe provides for the isolated storage of two components of a medicament until immediately prior to use of the syringe. One liquid component is stored in a collapsible chamber of a sealed capsule within a hollow plunger stem of the syringe, and the other component beneath the head of the plunger. A double headed needle arrangement between the head and stem of the plunger is caused to penetrate the plunger head and the capsule when the syringe is to be used so that the plunger may be drawn back to exhaust the contents of the capsule chamber into admixture with the component stored beneath the head of the plunger. Communication through the double headed needle arrangement is then interrupted before the plunger is used to eject the syringe contents through an external needle fitted to the syringe.

Abstract: A cartridge 444, 644, 744 is adapted for mounting upon a receptacle 442, 642 in a parenterial fluid administration set 420 for delivering a drug or other beneficial agent to a patient. The cartridge 444, 644, 744 includes a beneficial agent-containing chamber 606 slidable from a first, pre-use position to a second, post-use position. The cartridge includes a hollow tube 496 in which the chamber 606 is at least partially mounted. At least one cannula 500 is mounted to the hollow tube and extends opposite the chamber. A protective cover or cap 530 maintains a chamber protective position that prevents inadvertent movement of the chamber that would accidentally engage the cartridge chamber with a flow path member, such as the cannula. The cover is removed in order to engage the chamber.

Abstract: A method of preparing a self-curing two-component cement, which is particularly useful for the preparation of bone cement used in orthopedics, from a powder component and a liquid component. The method includes providing the powder component in a first at least partially evacuated inflexible container, providing the liquid component in a second inflexible container, and adding the liquid component to the evacuated powder component, such that the liquid floods the evacuated interspaces between the powder particles. An apparatus for carrying out this process is a syringe with a slidable piston, the syringe being sealed at its dispensing end by a removable plug. Preferably, the syringe is fitted with an axially collapsible spiral mixing device, one end of which is an elongated shaft which extends through the removable plug at the dispensing end. The elongated shaft can be rotated to homogenize the contents of the syringe, but during dispensing the mixing device collapses as the piston advances.

Abstract: A cartridge 444, 644, 744 having a drug or other beneficial agent 608 therein and including an adapter 477 is positioned on a receptacle 442, 642 within a parenteral fluid administration set 420. Also disclosed is an adapter 477' for connecting the receptacle 442, 642 to a chamber 606 having a beneficial agent therein. The cartridge and adapter permit a single opening through the injection site at the receptacle and at the chamber at opposite ends of the flow path means while still permitting simultaneous flow both into and out of the chamber and the receptacle.

Abstract: A container having two compartments for keeping two materials in separated relation. When it is desired that the two materials be intermixed, an actuator carrying a pair of piercing pins is inserted into ports of the compartments until membranes blocking exit of the materials from their respective compartment are punctured. When these membranes are punctured the materials are received at a mixing chamber where the materials are mixed.

Abstract: The invention is an integral container system designed for separately storing a liquid, such as a diluent, and a second substance, such as a medicament, and subsequently adding the second substance to the liquid in a simple and sterile operation. In one embodiment, a flexible I.V. bag is provided with a second substance dispensing cup containing a powdered medicament, which cup fits slidably in a sleeve passing through the walls of the bag. Fitted in the open end of the cup is a pierceable plunger. A hollow needle is held in position to pierce the plunger when the cup is pushed toward the needle. The needle is slidably held so that when it is pushed by the plunger, it will also pierce a diaphragm fitting over the sleeve. When both the plunger and the diaphragm are pierced, fluid access between the cup and the bag is had through the hollow needle. Diluent can then be injected into the cup to dissolve or slurry the powdered medicament.

Abstract: A syringe purging device comprises a liquid-tight chamber into which air and/or any excessive amount of a hazardous liquid, such as a chemotherapy drug, is ejected from a syringe to overcome the health hazard created by openly purging syringes into the air or into a pad of gauze material. A sharp open end of a hollow needle of a syringe is sealingly inserted into the liquidtight chamber, and the syringe is activated to purge any air and/or excess liquid into the chamber. The liquidtight chamber may be closed, with any liquid ejected thereinto being retained by absorption into a wad of absorbent material contained within the chamber. Alternately, the chamber may be vented to the atmosphere through a hydrophobic filter such that air injected into the chamber passes through the filter, but any liquid is retained within the chamber since it cannot pass through the hydrophobic filter.

Abstract: Various embodiments of an improved reconstitution device 30, 168, 170, 186, 242, 256, 274 are disclosed, directed to the proper mixing of two substances, and are particularly directed to the medical field for the reconstitution of a drug 36 which may be stored in a drug vial 32 with a diluent 60 stored in a flexible medical solution container 34 and used for the intravenous delivery of a medicament. In one embodiment the reconstitution device 30 includes an improved vial adapter 76 and bag adapter 78 which permit the permanent coupling of the vial 32 and liquid container 34. The bag adapter 78 may be rotatable relative to the vial adapter 76 to operate a valve including a stem channel 108 and a base post 148 on the vial adapter 76, a base segment channel 136 and a cut out portion 146 of a rim 140 on the bag adapter 78, and a sealing segment 80 disposed between the vial and bag adapter 76, 78.

Abstract: The unit delimits two compartments which are intended to contain each one product and which are separated by a separating element constituted by at least one cover perforatable as a result of the manipulation of a mixing perforator. This perforator is placed into one of the compartments, so that its cutting end comes to be near the above-mentioned separating element in the storage position, and that its other end is situated opposite a deformable obturating partition of the compartment. An element for manipulating the perforator is disposed in the extension of this latter, on the other side of the partition; it is displaceable for translation to pass from the storage position to a mixing position wherein it is acting on the perforator through the partition to cause it to cut the separating element. Can be used for storing a hair dye.

Abstract: A container for intravenous fluid has a triangular cross-section to permit improved utilization of space during packaging of several containers in boxes or cartons, and a first opening sealed by a membrane seal which can be pierced with the spike of a conventional intravenous set. A second opening of the container is surrounded with a neck portion forming a joint to which an intermediate member is pivotably mounted. The intermediate member includes a hollow cylindrical portion having two circumferential ribs which are adapted to hold the neck of a standard small vial containing solid antibiotics and the like. The intermediate member also includes an internally mounted hollow spike so that the seal of the antibiotic vial is penetrated by the spike when the vial is mounted to the intermediate member. The duct of the spike of the intermediate member is not aligned with the second opening of the container until the intermediate member is rotated or pivoted into an extreme position.

Abstract: A valvular system for the extraction and/or addition of liquids held in flexible sterilizable containers of plastic material, including an elastomeric semirigid hydraulic seal having two major superior and inferior faces and at least one minor lateral face. A housing of plastic material for the said elastomeric element. The valvular system is characterized in that at least one of the said major faces of the elastomeric element is at least partially spaced from the housing body.

Abstract: A package for enabling a user to mix a diluent with a hazardous material and then fill a syringe with the solution in such a way as to substantially prevent the hazardous material from entering the immediate atmospheric environment comprising a vial and a sealed bag enclosing the entire vial so as to provide exterior sealed containment for the vial in the event of unexpected failure of the vial container and elastomeric stopper assembly to sealingly contain the hazardous material. The vial is sealed within the bag so as to form a space exteriorly of the vial which is controlled by the bag and which is operable to receive any hazardous material in the form of aerosol or droplets that may pass outwardly through the elastomeric stopper assembly as a result of the withdrawal of the syringe needle therefrom and the increased interior gas pressure created within the vial container by the injection of diluent therein.