Closure Moved, Expanded, Or Flexed By Force Transmitted By Liquid Patents (Class 604/90)
  • Patent number: 11097055
    Abstract: An injector may include a container having a wall with an interior surface defining a closed sterile reservoir filled with a medical fluid or drug product. The injector may also include a fluid delivery system comprising a sterile container needle that is in fluid communication with the container in a delivery state, but may or may not be in fluid communication with the container in a storage state. The sterile container needle is attached to a connector, the connector mechanically coupled to the container to secure the sterile container needle to the container with the needle in the storage state. Further, the injector may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: August 24, 2021
    Assignee: AMGEN INC.
    Inventor: Scott R. Gibson
  • Patent number: 10829286
    Abstract: In combination a spouted pouch (1) to be filled with a flowable product by a filling machine, a plug (50), and a cap (70). The interference fit plug is releasably mounted over the top end of the neck of the spout body and hermetically seals the product passage of the spout body. The plug is adapted to be removed by the filling machine and to be replaced by pressing the plug onto the neck after filling of the pouch. The plug removal, filling, and replacing of the plug are preferably performed in an aseptic environment. The cap is after the filling of the pouch and the replacing of the plug onto the neck. The capping is preferably performed by a capping machine in a non-aseptic environment.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: November 10, 2020
    Assignee: Scholle IPN IP BV
    Inventors: Christopher John Murray, Jeroen Pieter Fiere, Chad Mueller, David Bellmore
  • Patent number: 10450124
    Abstract: A telescoping syringe suitable for use with medications and other flowable materials is presented. The telescoping syringe includes a one-way valve, a plunger, and a barrel. The valve includes a barrier, an outlet(s) through the barrier, and an annular extension extending from the barrier. The plunger includes an inlet(s) and a proximal wall fixed at one end of a first side wall. The valve directly contacts a distal end of the first wall so that an annular flange extending inward from the annular extension slidingly engages an annular groove along the first wall between first and second positions. The circumferential end of the first wall contacts the barrier in the first position to close the outlet(s). The circumferential end does not contact the barrier in the second position to open the outlet(s). A first reservoir is defined by the first wall, the proximal wall, and the valve. The inlet(s) permits gas to enter the first reservoir as fluid is transferred through the valve to a second reservoir.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 22, 2019
    Assignee: New Product Development Concepts LLC
    Inventors: Robert A. Kolonia, Brian J. Kolonia
  • Patent number: 9850058
    Abstract: A telescoping syringe suitable for use with medications and other ejectable or injectable fluids is presented. The syringe includes a plunger, a barrel, and a valve. The plunger is extendible from and retractable into the barrel. The plunger defines a first reservoir. The barrel defines a second reservoir as the plunger is extended from the barrel. The valve is disposed at one end of the plunger adjacent to a nipple extending from the barrel. A first sealing interface is formed by the valve and a distal wall along the barrel adjacent to the nipple. A second sealing interface is formed by an annular flange along the one-way valve and an annular groove along the plunger. A third sealing interface is formed by the valve and a circumferential end along the plunger. The sealing interfaces are closed prior to extension of the plunger from the barrel thereby preventing a gas from entering and a fluid from existing the first reservoir.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: December 26, 2017
    Assignee: New Product Development Concepts LLC
    Inventors: Robert A. Kolonia, Brian J. Kolonia
  • Patent number: 9764125
    Abstract: A multi-use intravenous infusion assembly is presented which includes a septum actuator having various features to prevent over-insertion of the septum actuator through a slit in a blood control septum. By preventing over-insertion of the septum actuator, the slit of the septum is able to repeatedly self-close following removal of an external Luer device. Thus, the intravenous infusion assembly may be used repeatedly without exposing a clinician to blood and other infusion fluids.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: September 19, 2017
    Assignee: Becton, Dickinson and Company
    Inventor: Yiping Ma
  • Patent number: 9320881
    Abstract: A multi-use intravenous infusion assembly is presented which includes a septum actuator having various features to prevent over-insertion of the septum actuator through a slit in a blood control septum. By preventing over-insertion of the septum actuator, the slit of the septum is able to repeatedly self-close following removal of an external Luer device. Thus, the intravenous infusion assembly may be used repeatedly without exposing a clinician to blood and other infusion fluids.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: April 26, 2016
    Assignee: Becton, Dickinson and Company
    Inventor: Yiping Ma
  • Patent number: 9320853
    Abstract: An administering device for administering an active substance from a multi-chamber container comprising a first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance, wherein the administering device comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device, the container being moveable relative to the housing, and the administering device further comprising a first indicator for indicating a position of the container relative to the housing upon completion of a mixing step, and a second indicator for indicating a position of the container relative to the housing upon completion of a venting step.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: April 26, 2016
    Assignee: TecPharma Licensing AG
    Inventors: Sofia Galbraith, Ulrich Moser, Juerg Hirschel, Ian Thompson
  • Patent number: 9205194
    Abstract: A mixing device and a retractable syringe comprising same are provided. The mixing device comprises concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. A mixing plunger is slidably located in the outer chamber. A seal located in the outer chamber is capable of axial movement, in response to depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in the inner barrel to a second position intermediate the apertures and vents in the outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in the inner chamber. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: December 8, 2015
    Assignee: Unitract Syringe Pty Ltd
    Inventors: Ramin Mojdehbakhsh, Peter J. Dungar, Ashley W. Palmer, Robert E. Johannesson, Philip A. Weaver, Aaron M. Weir
  • Patent number: 9198997
    Abstract: Tissue and other body structures may be protected using a hydrated composition made from free-flowing rehydratable particles or a rehydratable sponge comprising substantially collagen-free dehydrothermally crosslinked thiolated polysaccharide. Rehydration of crosslinked or uncrosslinked polysaccharide particles may be carried out without clumping by dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated particles or sponge may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: December 1, 2015
    Assignee: Medtronic, Inc.
    Inventors: Matthew Franco Myntti, Dana A. Oliver, Brian Vaccaro
  • Patent number: 9149581
    Abstract: Injection devices are disclosed for injections of substances. The disclosed devices separately may hold two separate substances, e.g., solid, liquid or gas substances, in separate compartments which are interrupted so that the separate substances come into contact during the activation of the device. One disclosed device includes a needle for injection and two substances that are mixed with only a few actions by the operator of the device. The device may or may not activate mixing by the removal of a sleeve which triggers compartment interaction through movement of pins, pegs, springs, wires, string, or other mechanisms which allow the materials held in separate chambers to come into contact with each other. Operator error during mixing and checking the dosage of substances to be injected is avoided with the disclosed devices. Also, the needle is maintained in a sterile state because the needle is held internally of the device until the sleeve is removed and the device begins to activate.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: October 6, 2015
    Assignee: GlucaGo LLC
    Inventors: Rush L. Bartlett, II, Arthur L. Chlebowski, Peter M. Greco, Jr., Zachary R. Gosnell, Jared L. West, Barry J. Davignon
  • Publication number: 20150141913
    Abstract: An apparatus comprises a plunger able to fit in a cartridge or syringe. The plunger includes an outer portion and a deflection portion. The outer portion is able to engage the body of the cartridge or syringe. The outer portion is operable to apply a first radial force to the cartridge or syringe. The deflection portion is positioned within the outer portion and is movable between a locked position and an unlocked position. The deflection portion in the unlocked position causes the outer portion to apply a second radial force to the cartridge or syringe.
    Type: Application
    Filed: June 26, 2013
    Publication date: May 21, 2015
    Inventors: Rush L. Bartlett, II, Peter M. Greco, JR., Barry J. Davignon
  • Patent number: 8998880
    Abstract: A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: April 7, 2015
    Assignee: Duoject Medical Systems Inc.
    Inventors: David L. Reynolds, Daniel MacDonald, Roger McCarthy
  • Publication number: 20150094652
    Abstract: In one aspect, a medical injector is provided herein having a body and an overcap releasably attached to the body configured to prevent mounting of a needle prior to mixing of components within the body. In a further aspect, a slidable collet may be provided useable to urge resilient members from an outward disrupted state inwardly to collectively define a needle mount. Advantageously, a medical injector is provided which ensures proper sequence in preparation of the device, particularly with respect to the step of allowing mounting of a medical needle to the device subsequent to preparation of the medicament to be administered.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 2, 2015
    Applicant: BECTON, DICKINSON AND COMPANY
    Inventors: RICHARD A. CRONENBERG, ASIF FAYYAZ, ATUL PATEL, MATTHEW DYLAN SWEENEY, LIONEL VEDRINE
  • Patent number: 8992469
    Abstract: An apparatus comprises a plunger able to fit in a cartridge or syringe. The plunger includes an outer portion and a deflection portion. The outer portion is able to engage the body of the cartridge or syringe. The outer portion is operable to apply a first radial force to the cartridge or syringe. The deflection portion is positioned within the outer portion and is movable between a locked position and an unlocked position. The deflection portion in the unlocked position causes the outer portion to apply a second radial force to the cartridge or syringe.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: March 31, 2015
    Assignee: Glucago LLC
    Inventors: Rush L. Bartlett, II, Peter M. Greco, Jr., Barry J. Davignon
  • Publication number: 20150051538
    Abstract: This pharmaceutical injection device comprises a main body case; a pharmaceutical syringe mounting portion provided inside the main body case; a piston that is provided so as to be movable with respect to a pharmaceutical syringe that is removably attached to the pharmaceutical syringe mounting portion; a drive mechanism for driving the piston; a controller that is electrically connected to the drive mechanism; and an acceleration sensor that is connected to the controller. When a manual mixing mode of the pharmaceutical syringe is selected, the controller changes to the next step (air venting mode) if the inclination angle of the main body case sensed by the acceleration sensor is greater than a specific value.
    Type: Application
    Filed: November 9, 2012
    Publication date: February 19, 2015
    Inventors: Shinsuke Hata, Tsuguhiro Kondoh, Seiji Kikuchi, Toshiaki Ilo, Yukio Nakajima
  • Patent number: 8834449
    Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: September 16, 2014
    Assignee: Ikomed Technologies, Inc.
    Inventors: Lindsay S. Machan, Daniel Gelbart
  • Publication number: 20140228746
    Abstract: An apparatus comprises a plunger able to fit in a cartridge or syringe. The plunger includes an outer portion and a deflection portion. The outer portion is able to engage the body of the cartridge or syringe. The outer portion is operable to apply a first radial force to the cartridge or syringe. The deflection portion is positioned within the outer portion and is movable between a locked position and an unlocked position.
    Type: Application
    Filed: December 5, 2013
    Publication date: August 14, 2014
    Applicant: GLUCAGO, LLC
    Inventors: Rush L. Bartlett, II, Peter M. Greco, JR., Barry J. Davignon
  • Patent number: 8764703
    Abstract: In a pre-filled syringe having an intermediate gasket, a liquid drug is enclosed in the second chamber located on the base end side with respect to the intermediate gasket while a powdered drug is enclosed in the first chamber located on the front end side with respect to the intermediate gasket. The intermediate gasket has at least two layers including a front end layer corresponding to a wall of the first chamber and a base end layer corresponding to a wall of the second chamber, and also has a low water-absorptive layer in the layer on the base end side with respect to the front end layer. The base end layer is formed of a material having low water-absorptivity and not lowering a pH of the liquid drug.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: July 1, 2014
    Assignee: Nipro Corporation
    Inventors: Takashi Asai, Tsutomu Takahashi, Kenyu Ito, Atsushi Ishikawa
  • Publication number: 20140163465
    Abstract: A one-part reconstitution device is described, for temporarily separating two substances into two compartments within a cartridge or syringe and allowing for mixture of the two substances within the cartridge or syringe. In various embodiments, the one-part reconstitution device may include an outer, contact portion configured to contact an inner surface of the cartridge or syringe, and an inner, deflection portion positioned within the contact portion. The deflection portion may be movable from a locked position, in which the deflection portion causes the contact portion to exert a first radial force against the inner surface, to an unlocked position, in which the deflection portion causes the contact portion to exert a second radial force against the inner surface. The second radial force may be less than the first radial force, and the contact portion and the deflection portion may comprise one part.
    Type: Application
    Filed: December 3, 2013
    Publication date: June 12, 2014
    Applicant: GLUCAGO, LLC
    Inventors: Rush L. BARTLETT, II, Peter M. Greco, JR., Barry J. Davignon
  • Patent number: 8728054
    Abstract: A syringe-carpule assembly comprising first and second carpules, a housing holding the first and second carpules in an end-to-end relationship, an outer hollow plunger rod supported by and slidable relative to the housing, and an inner hollow rod having first and second openings and being slidably arranged inside the outer hollow plunger rod. The inner hollow rod is slidable between first and second positions. The inner hollow rod in the first position has the first opening disposed within the first carpule and the second opening disposed within the second carpule. This allows liquid solvent in the second carpule to flow into the first carpule, which comprises an evacuated chamber containing solid matter that dissolves in the presence of that solvent to form a mixture. The second carpule is then removed and the mixture in the first carpule is injected into the patient.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: May 20, 2014
    Assignee: Synchrojet LLC
    Inventor: Steven Schulhof
  • Patent number: 8695819
    Abstract: A cap dispensing chamber to hold powder and/or liquids in a contained unit with a line of weakening, including but not limited to for bottles, pouches, cartons, cans, drums, IV bags, syringes, and any other type of container that can hold a product. The body and the plunger fits snugly with one another allowing ingredients to be stored and activated by an individual when on a as needed basis. A dust cover for allowing RFID, Nano and barcodes that can be applied during or post manufacturing or any location on or in the invention A body can be molded with a screw cap, snap lid, click-in, or by itself that can ultimately fit on any type or style container.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: April 15, 2014
    Assignee: Blast Max LLC
    Inventor: Michael R. Anderson
  • Patent number: 8684282
    Abstract: An atomizer delivery manifold or spray head with an adjustable spray pattern tip is provided. The adjustable spray pattern atomizer is especially useful for delivery of fibrin glues, and enables a fluid admixture to be applied precisely to a specific site in a wide range of spray patterns.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: April 1, 2014
    Assignee: Plantation Key Design Inc.
    Inventor: Dennis L. Steffen
  • Patent number: 8622956
    Abstract: An injection device including a volume for accommodating a product for administration, a piston for acting upon the product within the volume, and a stopper which can be arranged between an end of the piston facing the product and the product within the volume, wherein the piston includes a piston head configured to be sealed in a gas-tight manner, the piston head being separate from the stopper such that a negative pressure or vacuum region can be developed between the piston head and the stopper.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: January 7, 2014
    Assignee: Roche Diagnostics International AG
    Inventor: Ivan Heutschi
  • Patent number: 8568446
    Abstract: A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: October 29, 2013
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Takashi Kurokawa, Christopher W. Widenhouse, Agnieszka Seyda, Jeffrey S. Swayze, Foster B. Stulen, Mark H. Ransick, Richard W. Timm, Shailendra K. Parihar, Shelby L. Cook Kornbluth
  • Patent number: 8544682
    Abstract: A device for the serial ejection of at least two fluid components comprises a spacer (19) providing at least two states, i) a first state allowing a front piston (7) to be displaced forwards by action on a rear piston (17) while a fluid volume is retained in a rear chamber (5) and ii) a second state allowing the rear chamber to volumetrically shrink while fluid is transferred past (or through) the front piston thereby enabling the use of a liquid, initially provided in only the rear chamber, for the dual purposes of mixing and rinsing.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: October 1, 2013
    Assignee: Swedish Orphan Biovitrum AB
    Inventors: Jonas Fransson, Birger Hjertman
  • Patent number: 8523838
    Abstract: The present invention relates to a connector device to connect a first and a second fluid container, directly or indirectly. The connector device exhibit a first and a second connection means, a pierceable barrier member, a piercing member, a fluid transfer channel and a pressure normalization channel. The pressure normalization channel is arranged to normalize an increasing pressure inside second fluid container. A valve arrangement permitting fluid to flow in a first and a second direction is arranged in the pressure normalization channel. The valve arrangement exhibit a cracking pressure in at least the first direction. The present invention provides for a connector device which reduces the risk of clogging the barrier filter.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: September 3, 2013
    Assignee: Carmel Pharma AB
    Inventor: Hakan Tornqvist
  • Patent number: 8517983
    Abstract: A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: August 27, 2013
    Assignee: Arte Corporation
    Inventors: Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Patent number: 8500682
    Abstract: A medical injector is provided herein having a body; a reservoir containing first and second mixable component; a stopper; a plunger; a spring disposed to advance the plunger; a first releasable retainer for releasably retaining the plunger in a first state against force of the spring; a first trigger for causing the first releasable retainer to release the plunger; a second releasable retainer for releasably retaining the plunger in a second state against force of the spring; and, a second trigger for causing the second releasable retainer to release the plunger. The spring causes the plunger to advance so that the stopper traverses at least a predetermined extent of advancement thereby causing mixing of the first and second mixable components. Advantageously, with the subject invention, a medical injector is provided which allows for autoreconstitution with subsequent dose setting and autoplunger activation being activated by separate triggers.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: August 6, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Richard A. Cronenberg, Asif Fayyaz, Atul Patel, Lionel Vedrine
  • Patent number: 8485727
    Abstract: A multiple chamber container for separately storing components of a parenteral nutritional formulation is provided. The multiple chamber container may include frangible barriers, preferably peelable seals separating the chambers from each other. The container preferably facilitates the selective activation of the peelable seals to permit the admixing of less than all the separately stored components. The container may include a chamber positioned at each of the opposite lateral ends of the container and at least one additional chamber between the lateral chambers. The at least one additional chamber may have a longitudinal length substantially less than the longitudinal length of at least one of the lateral chambers. This configuration allows for selective opening of the seals since when rolling the container from the top avoids pressurizing the at least one additional chamber and inadvertent activation of a seal.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: July 16, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Jean Luc Trouilly, Freddy Desbrosses, Denis Bonnot, Christian Melin
  • Patent number: 8486006
    Abstract: A medical injector is provided herein which includes a body; a slidable button at least partially disposed in the body; a displaceable plunger disposed in the body; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first state against force of the spring. Upon a predetermined extent of sliding movement of the button, the button engages the releasable retainer so as to cause the releasable retainer to release the plunger thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon button activation, thereby minimizing premature or failed activations.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: July 16, 2013
    Assignee: Becton, Dickinson and Company
    Inventor: Richard A. Cronenberg
  • Patent number: 8486008
    Abstract: A medical fluid injector and methods for operation thereof. In certain embodiments, the medical fluid injector includes a medium that is expandable and contractible in response to a thermal gradient, a thermal device coupled to the medium, and a syringe interface coupled to the medium. The thermal device may include a heater, a cooler, or a combination thereof.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: July 16, 2013
    Assignee: Mallinckrodt LLC
    Inventor: Charles S. Neer
  • Patent number: 8454559
    Abstract: Hypodermic syringe having a barrel which with an inner wall thereof defines a reservoir, a closing-off device near the first end of the barrel, and a plunger that is movably placed in the second end of the barrel, wherein the closing-off device comprises a circumferential wall that sealingly abuts the inner wall of the barrel, at the side facing away from the nozzle is provided with a recess extending along a centre line of the closing-off device and over the full width thereof, which recess merges into the through-opening, with in the recess two diametrically opposite flexible locking members, extending in the longitudinal direction of the recess and towards the inner wall, which locking members engage into diametrically placed locking grooves in the inner wall, and at the side facing away from the nozzle, at a circumferential part of the closing-off device situated outside of the recess, is provided with two diametrically opposite and radially outwardly extending blocking members, that engage in diametrical
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: June 4, 2013
    Assignee: Addino B.V.
    Inventors: Richardus Gerardus Theodora Fierkens, Richardus Henricus Johannes Fierkens, Arnoldus Theodorus Maria Telkamp, Dirk Vogelaar
  • Patent number: 8454558
    Abstract: A hollow inner plunger for use within a syringe-in-syringe mixing system for mixing a two-part dental composition. The hollow inner plunger includes a body having a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a proximal end and a distal end. A sealing plug and rupturable membrane are disposed at the distal end of the body, and the sealing plug and rupturable membrane are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow inner plunger, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow inner plunger, and the hollow inner plunger is slidably disposed within the syringe barrel. The two components are initially separated by the rupturable membrane.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: June 4, 2013
    Assignee: Ultradent Products, Inc.
    Inventors: Neil Jessop, Bruce S. McLean, Jared Sheetz
  • Patent number: 8439864
    Abstract: An administering device for administering an active substance from a multi-chamber container comprising a first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance, wherein the administering device comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device, the container being moveable relative to the housing, and the administering device further comprising a first indicator for indicating a position of the container relative to the housing upon completion of a mixing step, and a second indicator for indicating a position of the container relative to the housing upon completion of a venting step.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: May 14, 2013
    Assignee: TecPharma Licensing AG
    Inventors: Sofia Galbraith, Ulrich Moser, Juerg Hirschel, Ian Thompson
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8409164
    Abstract: In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. In some embodiments, an anti-reflux valve is positioned within the extractor channel. The anti-reflux valve can be configured to impede or obstruct fluid returning to a fluid source after withdrawal of the fluid from the fluid source.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: April 2, 2013
    Assignee: ICU Medical, Inc.
    Inventor: Thomas F. Fangrow
  • Patent number: 8403883
    Abstract: A medical injector is provided herein having a body and a reservoir disposed in the body, the reservoir including at least first and second mixable components. At least one stopper is associated with the reservoir where distal advancement of the stopper over a predetermined distance causes mixing of the mixable components. A plunger is disposed in the body, along with a knob stem and a knob fixed to the knob stem so as to be rotatable therewith. A sleeve is telescopingly disposed over the knob stem, wherein the knob stem and the sleeve have cooperating elements formed thereon which selectively permit rotation of the knob stem to be transmitted to the sleeve so that the knob stem and the sleeve may rotate together. A spring is also provided for urging the sleeve distally. A releasable retainer releasably retains the sleeve against force of the spring. Rotation of the knob releases the sleeve and allows the spring to displace the sleeve distally.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: March 26, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Asif Fayyaz, Richard A. Cronenberg, Lionel Vedrine
  • Patent number: 8403923
    Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 26, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Steven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza
  • Patent number: 8403882
    Abstract: Disclosed is an applicator device (10) for applying a multi-component fluid, especially a multi-component tissue glue, comprising a plurality of substantially cylindrical supply containers (12) for respectively one component of the fluid to be applied, each supply container (12) having a front end (16) with an outlet opening (18), a rear end (22) opposite to the front end (16), and a slidably displaceable piston (24) arranged within the supply container (12) and having a piston rod (26) extending out of the rear end (22) for operating the piston (24). Moreover, the applicator device includes a manifold (72) having terminal ends (50,58) with a first port for fluid connection with the front ends (16) of the supply containers (12), the manifold (72) further having internal channels (62) extending from the first ports of the terminal ends (50,58) to an outlet site.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: March 26, 2013
    Assignee: Omrix Biopharmaceuticals, S.A.
    Inventor: Edit Goldberg
  • Patent number: 8394052
    Abstract: A plunger-barrel apparatus is adapted for use within a syringe-in-syringe mixing system for mixing a two-part composition (e.g., a dental composition). A hollow plunger-barrel body has a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a plunger receiving end and a dispensing end. An integral sealing plug and rupturable membrane is disposed at the dispensing end of the body and include a sealing plug portion and a rupturable membrane portion that are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow plunger-barrel body as described above adapted to contain a first component, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow plunger-barrel body, and the plunger-barrel body is slidably disposed within the syringe barrel.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: March 12, 2013
    Assignee: Ultradent Products, Inc.
    Inventors: Neil Jessop, Bruce S. McLean, Jared Sheetz
  • Patent number: 8382704
    Abstract: A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movemen
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: February 26, 2013
    Assignee: Medrad, Inc.
    Inventors: Arthur E. Uber, III, David M. Griffiths, David M. Reilly, Alan D. Hirschman, Kevin P. Cowan, Mark Trocki
  • Patent number: 8357147
    Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 22, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Brian D. Burkinshaw, John L. Wheeler, James B. Rogan, Steven I. Whitlock
  • Patent number: 8317743
    Abstract: A method for mixing and injection and an apparatus for performing the method includes the use of a needle and a needle base, a syringe attachment element and a mixing chamber engagement assembly including a needle chamber surrounding the needle and a first liquid conduit portion, sealed from the needle chamber. A mixing chamber engagement portion includes a second liquid conduit portion communicating with the first liquid conduit portion and a mixing chamber. When the syringe attachment element and the needle base are in a first relative engagement orientation liquid can flow between an interior of the syringe and the first liquid conduit portion and upon axially displacing the needle base and syringe attachment element to a second relative engagement orientation, liquid can flow between an interior of the syringe and the needle.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: November 27, 2012
    Assignee: Medimop Medical Projects Ltd.
    Inventor: Igor Denenburg
  • Patent number: 8313455
    Abstract: Syringes for holding fluids susceptible to void formation when the syringe and fluid are frozen and thawed before use. The interior surface of the syringe barrel is modified by exposure to a plasma such that the incidence of void formation in the fluid is prevented or, at the least, significantly reduced in comparison with conventional syringes.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: November 20, 2012
    Assignee: Nordson Corporation
    Inventors: Henry DiGregorio, David Foote, James Getty
  • Patent number: 8252228
    Abstract: A kit is described including at least one container including a predetermined quantity of sterilized biodegradable carriers in a powder form having a treatment agent disposed therein. The kit further includes a delivery device for delivering the predetermined quantity of sterilized biodegradable carriers with the treatment agent disposed therein to a treatment site. In other embodiments, methods are described for producing the sterilized treatment agent loaded biodegradable carriers and delivering the sterilized carriers to a treatment site.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: August 28, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Abigail Freeman, Thierry Glauser, Paul M. Consigny
  • Patent number: 8231568
    Abstract: Syringes for holding fluids susceptible to void formation when the syringe and fluid are frozen and thawed before use. The interior surface of the syringe barrel is modified by exposure to a plasma such that the incidence of void formation in the fluid is prevented or, at the least, significantly reduced in comparison with conventional syringes.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: July 31, 2012
    Assignee: Nordson Corporation
    Inventors: Henry DiGregorio, David Foote, James Getty
  • Patent number: 8226627
    Abstract: A reconstitution assembly includes: a flexible bag containing a diluent; a drug vial containing a drug; a reconstitution device further comprising: a first sleeve connected to the first container; a second sleeve connected to the second container, the second sleeve being associated with the first sleeve and movable axially with respect thereto from an inactivated position to an activated position; a piercing member positioned in the sleeves, the piercing member providing a fluid pathway between the bag and vial when the sleeves are in the activated position.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: July 24, 2012
    Assignee: Baxter International Inc.
    Inventors: Thomas A. Fowles, Robert J. Weinburg
  • Patent number: 8206413
    Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: June 26, 2012
    Assignee: Codman & Shurtleff, Inc.
    Inventors: Donald K. Jones, Vladimir Mitelberg
  • Patent number: 8177099
    Abstract: A cartridge for storing and dispensing substances that are in paste form and/or capable of flow is formed by at least one tube, in which a closure piston and a dispensing piston adjustable by means of a piston rod are disposed, so as to form a seal, in such a manner that a chamber is formed between the pistons. At least one passage opening is provided in the closure piston, and at least one projection is provided in the tube assigned to this closure piston and/or an outlet opening, whereby the passage opening and the projection are adapted to one another, in terms of their shape, in such a manner that the closure piston can be displaced between a closure position, in which the chamber is closed, and a dispensing position, in which the chamber stands in a flow connection with the outlet opening, by means of the passage opening.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: May 15, 2012
    Assignee: Kettenbach GmbH & Co. KG
    Inventors: Matthias Suchan, Alexander Bublewitz
  • Patent number: 8133198
    Abstract: A medical fluid injector and methods for operation thereof. In certain embodiments, the medical fluid injector includes a medium that is expandable and contractible in response to a thermal gradient, a thermal device coupled to the medium, and a syringe interface coupled to the medium. The thermal device may include a heater, a cooler, or a combination thereof.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: March 13, 2012
    Assignee: Mallinckrodt LLC
    Inventor: Charles S. Neer