Abstract: An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that has a plug that is moved from a sealing position into a mixing position when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert “funnels” the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle assembly allows for better flow through the filter. An actuation assembly drives the plug into the mixing position and forces the mixed medicament through the needle and into the user.

Abstract: An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition into a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.

Abstract: A syringe device and a method of preparing medicine using the device capable of easily and accurately performing operations for mixing and dissolving a lyophilized product into a dissolution liquid before use. A double ended needle assembly and an intermediate holder are fitted to the first cylindrical part of a connection holder, a first syringe in which the dissolution liquid is stored is inserted into the first cylindrical part through the intermediate holder, and a second syringe in which the lyophilized product is stored in a depressurized state is fixedly inserted into the second cylindrical part of the connection holder. First, the intermediate holder is locked by a finger hooking projected piece, the first syringe is pushed into the intermediate holder in the locked state of the double ended needle assembly at an initial position by locking ribs, and the first syringe is unsealed by one end of the double ended needle.

Abstract: The present invention is directed to an assembled syringe for administering powder medicament in the field of medicine. By using a connecting tube, a solvent bottle containing diluent communicates with a solute bottle containing powder by external force, and the diluent is injected into the solute bottle through the connecting tube under pressure. After the powder is dissolved and mixed uniformly, the mixed solution is injected directly into a patient or added to a transfusion bottle or tube. Both the solvent and solute bottles are packaged into a sleeve to avoid contamination. Buckles on the plunger sleeve are fitted into restricting slots on the sleeve. The fitting of the slots and buckles restricts the position of the syringe, self-locking and controlling the magnitude of force by which the solute bottle is communicated with the solvent bottle, controlling the depth of insertion of the needle into the body, and preventing misoperation or damage during transport, fetching and using.

Abstract: The invention provides a miniaturized, implantable drug delivery device and a method of delivering over a prolonged period of time one or more drugs using such a device. The drug delivery device can be adapted for attachment to the outer surface of an eye. Once attached to the outer surface of an eye, the device can deliver one or more drugs directly into the eye for preventing or ameliorating the symptoms of a particular ocular disorder.

Abstract: A multichamber ampoule with a locking and dispensing mechanism to store several substances and to dispense a mixture consisting of several substances, possessing a multiple-plug closure (140) with several plugs to selectively close and open several outlet openings in the multichamber ampoule, and an adapter (130) for mixing the substances and dispensing the mixture, wherein the multiple-plug closure (140) and the adapter (130) are connected to each other in an assembly designed to be removed from the multichamber ampoule (FIG. 23).

Abstract: A separation assembly for initially keeping a first component separate from a second component includes a generally cylindrical body slidably supported within a container between the first and second components. The body includes a seal structure having an inner seal member that initially seals the first component from the second component. In response to a predetermined operating condition, the inner seal member allows the first component to flow through at least one flow path in the seal structure to mix with the second component. The body further includes a flow distributing member disposed adjacent the seal structure to evenly distribute the first component into the second component. The seal structure and the flow distributing member form a single unit.

Abstract: The invention relates to a method and a device for lyophilizing, reconstituting and administering a reconstituted substance. The device has an elongate housing comprising a dispensing-side front housing end and a housing end lying opposite it. A first chamber with a lyophilizate contained in it is disposed in the housing in the region of the front housing end, which is tightly sealed at its end facing the front housing end by means of a removable closure and in the direction of the rear housing end by means of a plunger. A second chamber is provided or formed in the housing in the region of the rear housing end, which is connected by means of at least one opening to the ambient atmosphere. This opening is closed by a membrane which is permeable to gas but not to bacteria.

Abstract: A liquid-powder drug prompt-mixing type automatic syringe includes an injecting assembly, a drug-mixing assembly and a shooting device. The injecting assembly includes an injecting outer sleeve, in which the mouth of a blocking ampoule is slidably socketed, a needle is coaxially connected to the blocking ampoule by a hub; the drug-mixing assembly includes a drug-mixing outer sleeve, in which a precharging pressure menstruum bottle by a drug-mixing needle bracket; the shooting device includes a shooting outer sleeve and a spring pushing rod mechanism slidably socketed in the shooting outer sleeve a movable joining mechanism allows the injecting assembly to alternatively connect the drug-mixing assembly and the shooting device respectively. A liquid drug automatic syringe includes said injecting assembly and the shooting device.

Abstract: Apparatus is described for administering a substance to a subject. A vial contains the substance, an inner surface of the vial being shaped to define a protrusion therefrom. A stopper within the vial is slidably coupled to the vial. A first threaded element is (a) rotatable and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. The protrusion impedes rotation of the second threaded element with respect to the vial. The distal end of the second threaded element remains proximal to a distal end of the stopper during rotation of the first threaded element. The first threaded element, by rotating, linearly advances the stopper and the second threaded element toward a distal end of the vial. Other embodiments are also described.

Abstract: A mixing syringe and method for using the mixing syringe are provided. The mixing syringe comprises a housing having a first compartment for containing a first component, an outer plunger having a second compartment for containing a second component, and an inner plunger. Prior to use, a seal separates the first and second components. To prepare the mixture, the seal is pierced and the two components are mixed. The mixing syringe and its method of use are particularly suited to applications in which at least one of the mixture components is a relatively highly viscous material.

Abstract: Embodiments of the present invention provide a device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first element capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. In embodiments, the first element may be fully or partially microporous or a separate intermediate microporous membrane may be provided. Also provided are methods of mixing or moving a drug within a reservoir using various mixing elements. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing a device in accordance with embodiments of the present invention.

Abstract: A medicine mixer for applying drug comprises a menstruum vial (12), an outer cannula (2) and a solute vial (11) (powdered drug ampoule) which are in one. Retaining ring (1), chuck ring (4) and convex ring (8) are disposed respectively at up portion, middle portion and nether portion of the inner wall of the outer cannula (2). An inner cannula (5) with a ducting needle (3) is disposed between the chuck ring (4) and the convex ring (8). In use the lower end of the outer cannula (2) is inserted to the opening (14) of the solute vial (11), and the opening (13) of the menstruum vial (12) is inserted into the retaining ring (1) of the outer cannula (2), so that rubber plugs (10,9) are pierced successively by the ducting needle (3) to connect two vials and thus mix drug. Then the outer cannula (2) is unfixed and the drug is applied to an infusion bottle (15).

Abstract: A device for delivery of medicament includes a main housing, a container having at least two compartments, each containing a component of the medicament to be injected, and arranged to be connected to a patient delivery element, a longitudinally movable piston and a spring arrangement acting on the piston to exert a force on the components, a first holding element for holding the piston in a force-loaded state, and at least one activator for releasing the piston, a second holding element for stopping the piston when it has moved a certain first distance after one activation of the at least one activator and holding the piston in that position, wherein the force from the piston/spring arrangement and the movement causes the compartments to communicate with each other and the components to mix.

Abstract: Disclosed is an injection device for properly dissolving pharmaceutical agents contained in a two-compartment syringe having slidable front and rear walls, and then performing portionwise multiple injections. The injection device comprises a front casing designed to enclose and hold the two-compartment syringe with a double-ended needle attached to the front end of it, a rear casing designed to receive the thus held two-compartment syringe being inserted in the rear-end first manner, and to lock and hold the front casing, a piston rod placed in the rear casing and designed to push from behind and carry forward the slidable rear wall, wherein the piston rod can be pushed forwardly from behind the rear casing, and a spring provided so that, when the front end of the piston rod is moved backward, the spring may be once compressed and then push the piston rod to a forward position again, and forwardly drives the slidable rear wall to abut on the slidable front wall.

Abstract: The present invention is a fluid dispensing device particularly suited to medicine but also having many other applications. The user manually and selectively dispenses any of one or more fluids, typically a drug, contained within the device. Generally, the device comprises a frame that holds multiple hypodermic syringes and channels the dispensed fluids through a manifold. A flushing solution, for example a saline solution, enters the manifold, flows past each of the points where the syringes input into the manifold and continues to flow out of the device to a patient where the flushing solution and dispensed fluid are delivered to a patient.

Abstract: A mixing syringe having a first sealed chamber containing a powder (powder housing) and a second sealed chamber containing a liquid (liquid housing). When the user needs to inject a patient, he or she holds the mixing syringe approximately upright and depresses a plunger. This motion causes a piercer to pierce a foil seal separating the two chambers. The liquid then drops down into the powder housing. The liquid flows through a passage in a piston located in the powder housing, where it then comes in contact with the powder itself. As the user continues pressing the plunger downward, the piercer comes to rest within the piston and seals the passage through the piston, thereby locking the piercer and piston together. The device is then ready for an injection. As the plunger is further depressed, the piston expels the powder and liquid mixture through a needle.

Abstract: A syringe assembly consists of two basic types of assembly units: a dispensing unit, and a separate, independent plunger unit. The dispensing unit and the plunger unit are assembled together coaxially to form a two-unit syringe assembly for storage or prior to use. At least the dispensing unit is a container for a material to be dispensed and, by inserting one or more extension units between the dispensing unit and the plunger unit, additional compartments may be added. Each extension unit may contain a different component of a formulation in any predetermined quantity. The syringe assembly allows the user to store one or more components of a formulation in separate individual units that can be assembled easily into a single multi-compartment syringe assembly, which can store the multiple components separately until they are ready for use, at which time the components may be mixed to form the formulation.

Abstract: A mixing syringe having a first sealed chamber containing a powder (powder housing) and a second sealed chamber containing a liquid (liquid housing). When the user needs to inject a patient, he or she holds the mixing syringe approximately upright and depresses a plunger. This motion causes a piercer to pierce a foil seal separating the two chambers. The liquid then drops down into the powder housing. The liquid flows through a passage in a piston located in the powder housing, where it then comes in contact with the powder itself. As the user continues pressing the plunger downward, the piercer comes to rest within the piston and seals the passage through the piston, thereby locking the piercer and piston together. The device is then ready for an injection. As the plunger is further depressed the piston expels the powder and liquid mixture through a needle.

Abstract: A dual-chamber type prefilled syringe comprises a cylindrical body within which a front plug member, a middle plug member and an end plug member are hermetically fitted to form a first chamber and a second chamber. The cylindrical body has an inner surface formed with a bypass. When the middle plug member moves to a position where the bypass is formed, the first chamber is communicated with the second chamber for the first time via the bypass. In this beginning state of liquid transfer (S), an inner volume (VS) of the cylindrical body between a leading end of the cylindrical body and a rear end of the front plug member is set to be at least 60% of a volume (VC) of a second component. When liquid component within the second chamber flows into the first chamber, it is possible to prevent part of the liquid component from passing through the first chamber to reach a portion for attaching an injection needle at a leading end of the cylindrical body.

Abstract: Apparatus and methods for generating foam are disclosed. The inventions can be used for generating foam for sclerotherapy. A foaming element can be agitated within a foaming chamber by a drive unit that does not touch the foaming element, but actuates it from outside the foaming chamber. The foaming element and drive unit can be magnetically coupled. A syringe can be used to form a foaming chamber.

Abstract: A medical pump, comprising a reservoir having a fluid enclosing portion and a tubular element, the inside of which is arrangeable in fluid communication with the fluid enclosing portion for allowing fluid to pass into the tubular element. The fluid enclosing portion contains a volume of fluid sealed from communication with air and the fluid enclosing portion is adapted to reduce in volume essentially to the same extent as any volume of fluid transferred into the inside of the tubular element. The invention also relates to a method of delivering a medical fluid.

Abstract: A disposable cassette for mixing an intravenous drug in a vial to a patient includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike and a chamber. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. A valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.

Abstract: The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebulizer, as well as an active substance concentrate in which the active-substance is present as a solution or suspension for storage purposes.

Abstract: The apparatus for production of mixtures from two components has a container for each and devices to combine the components in the mixing space and for extrusion of the mixture. The powdered component (4) is situated in the lower part of the inner space (21), which is sealed by a bottom (10). This carries a nozzle (2) with closure membrane (3). The inner space (21) is closed on the top by the lower wall (6) and the sliding seal (8). The liquid component (9) is situated in the inner space (18) of the inner hollow cylinder (5). This is closed on the top by the upper wall (11). The lower and upper wall (6) and (11) each have an opening with sealing lips (7) and (12) that are closed by parts of the mixing rod (15). A torus (20), a section with smaller diameter (19), a mixing disk (22), as well as a mandrel (24), are present on the lower part of the mixing rod (15).

Abstract: The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance concentrate in which the active substance is present as a solution or suspension for storage purposes.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, an activation assembly and a needle assembly for dispensing a dissolved medicament to a user. A dry compartment for storing a predetermined dry charge of dry medicament is located within the interior chamber. A wet compartment for storing a predetermined amount of liquid injection solution is also located within the interior chamber. A separation assembly separates the dry compartment from the wet compartment. The separation assembly prevents transfer of the liquid injection solution from the wet compartment to the dry compartment prior to activation of the automatic injection device. One or more medicament support assemblies located within the dry compartment prevent the passage of undissolved medicament from the dry compartment.

Abstract: Several improvements are disclosed for a drug delivery pack with dry reagent in a housing, each of which can be employed independently or in conjunction with others of the improvements. A novel spring is provided with two spring columns extending in parallel between a spring top and a spring bottom. The spring is particularly designed for fitting within the housing and compacting a dry reagent bed. A plunger mechanism to ratchet housing portions between two positions. In one position, a compression component adjacent the reagent bed is relatively uncompressed, such that it does not “set” over time. When the user is about to use the drug delivery device, the plunger is slid to compress the compression component so that it exerts pressure on the reagent bed. A similar sliding mechanism can also divert a stream of diluent through the housing from a priming path, where diluent bypasses the reagent bed, to a functional path passing through and eroding the reagent bed.

Abstract: A method in which photodynamic therapy is employed to inhibit, stabilize or reduce occlusions within the cardiovascular system by utilizing light within the spectral region of approximately 390 to approximately 610 nm.

Abstract: A syringe, which may be pre-filled, and a method of using the syringe is disclosed to provide sequential injection of two different fluids without mixing thereof. The syringe comprises in a first version a plunger and an intermediate disc sealingly disposed within a generally cylindrical barrel, with an outlet portion distal of the barrel, the outlet portion being generally larger in diameter so that as the disc is advanced into it far enough to substantially inject the first fluid the disc loses sealing engagement and the second fluid is then expelled around the disc and through the syringe opening. Baffles are provided within the outlet portion to prevent the disc from inadvertently sealing the opening, and channels may be provided around the baffles.

Abstract: A flexible container is provided for the storage and administration of medical solutions. The container incorporates a transparent front sheet made from a planar layer of a polymer and an opposing rear sheet. The rear sheet is made from a planar laminate layer. The front and rear sheets are sealed together along a common peripheral edge to form a volume enclosure. The volume enclosure is constructed of materials having high oxygen and moisture barrier properties which allows the container thermoplastic to be stored for extended periods of time without degrading the contents. The volume enclosure is then inflated with a pressurized gas to permanently stretch the front and rear sheets outwardly and to thereby increase the volume capacity of the container. An alternative embodiment of the container incorporates multiple compartments, separated by peelable seals, for containing a diluent and a medicament.

Abstract: The multi-component mixing capsule with dispensing device has a container part in which a component can be accommodated. A further component is arranged in a piston which is sealed at one end by a foil disk and a holed disk. At the other end, the piston is sealed by a ram which, in a first operating step, forces the liquid component from the piston into the mixing space of the container part and, in a second operating step, also forces the piston downward so that the mixed compound can emerge from the dispensing device.

Abstract: A dual-chamber type prefilled syringe comprises a cylindrical member made of glass or the like, an interior area of which is partitioned into a front chamber and a rear chamber by a plurality of plug members. The respective chambers preliminarily and independently contain injection medicine and its dissolving solution or the like.

Abstract: The production of a protein free synthetic polyisoprene which has both low levels of chemical impurities and good physical properties has yet to be realized. It has now been envisioned that the use of neodymium catalyzed polyisoprene will offer the combined advantages of both a clean, as well as, high cis-1,4 polymer. Synthesis of polyisoprene rubber using a neodymium based catalyst system is described. Characterization of the material shows the absence of an ultra high molecular weight fraction and the presence of very high cis-1,4-microstructure. Gum stock and black filled compound studies comparing neodymium polyisoprene with natural rubber, titanium polyisoprene, and lithium polyisoprene have been performed. Results indicate that polyisoprene rubber synthesized using a neodymium catalyst system (Nd—PI) has similar stress-strain and tear properties as synthetic titanium polyisoprene.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, a filter assembly, an activation assembly and a needle assembly. In accordance with the present invention, the interior chamber may include a dry compartment for storing a predetermined dry charge of dry medicament therein, and a wet compartment for storing a predetermined amount of liquid injection solution therein. The filter assembly enhances the laminar flow of fluid between the wet compartment to the dry compartment prior to the pressurization of the liquid injection solution within the wet compartment.

Abstract: A multi-compartment syringe for storing two or more substances in separate compartments comprises a tubular body having an opening at each end and a plunger. The body has two or more compartments defined along its length, where each compartment has a successively larger diameter. The plunger has a plunger head at one end that partitions the first and second compartments and one or more bungs, slidable along the plunger's shaft, for partitioning each of the other compartments. The plunger head and the bungs can be unsealed to establish a flow communication between the compartments.

Abstract: A bypass type prefilled syringe has a tubular body formed with a bypass for establishing communication between front and rear compartments for preliminarily storing medicament and pharmaceutical liquid, respectively. A gasket for dividing interior space of the tubular body into the front and rear compartments includes a plurality of circumferential ribs . A plurality of annular recesses are each formed between neighboring ones of the circumferential ribs. First and second axial slots are formed on the circumferential ribs so as to define a bent outflow path for the pharmaceutical liquid at the time of communication between the front and rear compartments via the bypass.

Abstract: A syringe, which may be pre-filled, and a method of using the syringe is disclosed to provide sequential injection of two different fluids without mixing thereof. The syringe comprises in a first version a plunger and an intermediate disc sealingly disposed within a generally cylindrical barrel, with an outlet portion distal of the barrel, the outlet portion being generally larger in diameter so that as the disc is advanced into it far enough to substantially inject the first fluid the disc loses sealing engagement and the second fluid is then expelled around the disc and through the syringe opening. Baffles are provided within the outlet portion to prevent the disc from inadvertently sealing the opening, and channels may be provided around the baffles.

Abstract: Multipurpose fluid applicators and applicator tips, particularly suitable for surgical purposes, are disclosed. The applicators and applicator tips are specifically designed for dispensing various combinations of sterile pressurized gas, suction, irrigation and sealant agents, including a mixed liquid sealant agent. Preferred embodiments employ a dual-acting valve selectively to control the flow of gas or suction which valve is capable of simultaneously varying flow from a source and the venting of that flow to atmosphere.

Abstract: A dual-chamber syringe has a plunger within an inner delivery chamber in fluid communication with an ejection port. The deliver chamber is formed within a tubular element axially slidable within a tubular guide. The tubular guide and the syringe outer barrel form an outer reservoir chamber. The outer reservoir chamber is sealed from the delivery chamber while the tubular element is in a first position within the guide. Upon withdrawal of the plunger, frictional contact imparted by the plunger seal causes the tubular element to slide away from sealing engagement with the barrel into a second position within the guide. In the second position of the tubular element, a fluid passageway is opened from the reservoir to the delivery chamber allowing fluid to be drawn into the delivery chamber. A porous seal between the plunger rod and barrel allows air into the reservoir during transfer of fluid to the delivery chamber.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The injection device includes a housing assembly, a dry compartment located within the housing for storing a predetermined dry charge of dry medicament therein, and a wet compartment located within the housing for storing a predetermined amount of liquid injection solution therein. The injection device further includes an activation assembly that enables the pressurization of the liquid injection solution in the wet compartment. The activation assembly also enables the compression of the dry medicament within the dry compartment upon activation of the automatic injection device.

Abstract: An injection syringe generally comprised of a multichambered cylindrical ampule, a tripartite case of a front case; a middle case; a rear case, and a needle-holder, and a plunger: the multichambered cylindrical ampule including two chambers of a front space and a rear space, the front space being sealed forwardly with a packing penetrable by a needle and sealed rearwardly with a movable front gasket, and the rear space being sealed forwardly with the front gasket and sealed rearwardly with a movable rear gasket, and the ampule also including a bypass route longitudinally arranged on inner surface of the ampule such that the front gasket is located to take a position rearwardly apart from the bypass route before dissolution of a solid medicine, wherein the front space for admission of the solid medicine is separated from the rear space for admission of a medicinal solvent or dispersing agent; the middle case also including a short thread or fixer means provided externally at midportion thereof, and the rear ca

Abstract: A multi-chamber renal dialysis container having at least two compartments and containing concentrated glucose in a first compartment and a hydrochloric acid solution containing electrolytes in a second compartment. The compartments are separated from one another during storage and transportation by separable peel seals, and the solutions can only be mixed with one another by the opening of the peel seals. An outlet of the multi-chamber container is separated by a further peelable seal, whereby a substantially empty third chamber is formed.

Abstract: The present invention is directed to a drug delivery device. The device includes an interior chamber and a seal structure. In accordance with the present invention, the interior chamber may include a first, liquid medicament compartment and a second medicament compartment. The seal structure is conditionable to permit fluid to pass therethrough upon pressurization of the fluid. The seal structure preferably includes a sealing member which moves from a first sealed position into a second by-pass position upon pressurization of the liquid injection solution in the wet compartment of the housing assembly. Such by-pass movement of the sealing member enables the liquid injection solution to flow through the seal structure into the second ingredient compartment and mix for injection.

Abstract: There is provided a pre-loaded multi-chamber syringe including an elongated hollow tube having first and second ends. The first end of the tube receives a needle support and the second end of the tube receives a plunger assembly. A moveable gasket is received between the one end of the plunger assembly and the first end of the tube thereby forming first and second chambers. Each chamber receives a liquid. A hollow needle extends from the needle assembly initially into the first chamber. When the plunger is depressed, the liquid from the first chamber is expelled through the hollow needle and the gasket moves to come in contact with the hollow needle wherein the hollow needle penetrates the gasket and thus extends into the second chamber so that the liquid from the second chamber is then expelled through the hollow needle.

Abstract: A multi-compartment syringe for storing two or more substances in separate compartments comprises a tubular body having an opening at each end and a plunger. The body has two or more compartments defined along its length, where each compartment has a successively larger diameter. The plunger has a plunger head at one end that partitions the first and second compartments and one or more bungs, slidable along the plunger's shaft, for partitioning each of the other compartments. The plunger head and the bungs can be unsealed to establish a flow communication between the compartments.

Abstract: Ampoule for dispensing a substance comprising: a container having a chamber therein for storing a substance to be dispensed; a piston arranged in the chamber so as to be displaceably in longitudinal correction of the chamber; an outlet means which can be connected to the container such that a fluid communication is established between an inlet portion of a discharge passage of the outlet means and an outlet opening of the chamber; and a plug closure means being insertable in a fluid-tight manner into the outlet opening of the chamber and, when it has been fluid-tightly inserted into the outlet opening, being displaceable by the outlet means connected to the container in direction towards the interior of the chamber from a closed position into an open position in which a fluid communication is provided between the interior of the chamber and the inlet portion of the discharge passage of the outlet means via the outlet opening of the chamber, the plug closure means having retaining means retaining the plug clos

Abstract: An infusion bag exhibiting an internal space which is surrounded by flexible walls, at least one outlet channel arranged through one of the walls for communication with the interior of the infusion bag, a communicating member integrated with the walls of the infusion bag which exhibits an opening accessible from the exterior of the infusion bag and an inlet channel which connects the opening with the interior of the infusion bag. An infusion system includes the infusion bag and a connecting member.

Abstract: A pre-filled syringe having an elastic-sliding valve to produce a hermetic closure inside a pre-filled syringe which keeps the liquid content to be injected totally isolated, in order to prohibit the liquid from coming in contact with the needle or the external air.

Abstract: A method and a needleless injection system for administering a medication. In order to simplify as far as possible the handling necessary for loading the injector with medication and thereby eliminate risks caused by a complex handling the method and system according to the invention provide loading of medication into a needleless injector device by means of a syringe prefilled with a medication, this loading step preferably including connecting the syringe to the injector device by means of a suitable coupling member or adapter and operating the syringe for transferring medication prefilled therein into the injector device. After this transfer the syringe and/or the coupling member or adapter are detached from the injector device, which is then ready to be operated for ejecting the loaded dosage of said medication from the injector device and thereby pass the selected dosage through the skin of an injection receiver.