Abstract: A resealable vial connector assembly includes a transfer set having a body dimensioned for slidable insertion into a vial. The body includes an axial passageway for fluid communication into or out of the vial. A stopper support extends downwardly from the body and is dimensioned for receiving spaced apart upper and lower vial stoppers. The stopper support includes at least one passageway communicating with the axial space between the stoppers and with the passageway through the body. Upper portions of the transfer set are configured for threaded engagement with a luer collar of a medical fluid delivery instrument such as a hypodermic syringe or intravenous bag. The transfer set is configured for releasable locking engagement with the vial in a first position where both stoppers seal the entrance to the vial and in a second position where the lower stopper permits fluid communication between the vial and the passageway through the transfer set.

Abstract: A syringe for the sequential withdrawal of a first liquid and a second liquid. The syringe has a barrel, a proximal piston moveable along the barrel to define a variable volume chamber intermediate the piston and the end of the barrel, and a distal chamber divider piston for separating the variable volume chamber into primary and secondary reservoirs. A flow channel is defined along the syringe for providing flow connection between the primary and secondary reservoirs. An element links the two pistons so that as the proximal piston is moved away from the distal piston, the first liquid enters the first reservoir and thereafter the second liquid enters the secondary reservoir.

Abstract: An improved syringe is provided which can be used in any step of preparation of a medicament by vacuum freeze-drying, etc., storage of a medicament, mixing of medicaments and dosing of a medicament in a sanitary and stable manner. The syringe comprises a cylinder having a front end part at one end and an opening part at another end and a bypass running in the longitudinal direction near the central position of the cylinder on the inner wall within the cylinder. A first sealing stopper is adapted, at a position toward the opening part of the cylinder from the bypass within the cylinder, to form a first compartment between the front end of the cylinder and the first sealing stopper. A second sealing is stopper adapted, at a position toward the opening part of the cylinder from the first sealing stopper within the cylinder, to form a second compartment between the first sealing stopper and second sealing stopper.

Abstract: The invention relates to an injection syringe for mixing and applying injection substances having a syringe cylinder and a plunger displaceable therein. The plunger has a stopper at its distal end tightly engaged against the inner surface of the cylinder to form an injection volume in the syringe cylinder. A mixing plunger is displaceable in longitudinal direction and guided through the plunger. The mixing plunger projects from the stopper at its proximal end and, at its distal end, has a mixing piston with at least one opening, passing through the surface of the piston. Injection substances can pass through the one opening when the mixing piston is displaced in the injection volume. An effective thorough mixing of the injection substances takes place through to-and-fro movement of the mixing piston in the injection volume.

Abstract: A prefilled syringe is capable of separate storage of different substances before use. It includes a tubular body having an injection needle at one end and a plunger at the other end, and a partition axially slidable in the tubular body. The partition includes a front part and a rear part independent of each other, and as a whole divides the interior space of the tubular body into a front compartment and a rear compartment in a sealing manner for storing mutually different substances. A bypass is disposed generally between the front and rear compartments to introduce the substance in the rear compartment into the front compartment when the partition is slid under pressure provided by the plunger to be adjacent to the bypass to thereby mix the substances immediately prior to injection.

Abstract: A disposable cartridge containing a buffering solution for attachment to a local anesthetic carrier in order to alkalize the anesthetic. The cartridge is provided with a needle which permits the buffering solution to enter the carrier and mix with the anesthetic solution.

Abstract: An air and liquid-tight container is capable of storing different substances in different compartments sealingly separated by a front gasket having two separate parts that are independently slidable. A rear gasket is connectable to a push rod so as to function as a plunger, the front gasket being slidable in response to sliding of the rear gasket, thereby enabling the substance in the rear compartment to be introduced into the front compartment through a bypass. The front and rear gaskets are encased in the tubular body at a compressibility C (%) of 2% to 10%, with the product of the compressibility and the contact area (mm.sup.2) of the gaskets with the inside wall of the tubular wall falling within the range of 150 to 400.

Abstract: An automatic injector for the separate storage of a solid and a solvent for this solid. The injector comprises a discharge mechanism, a cartridge assembly and a front cover which is connected to a front portion of the cartridge assembly and provided at its front with a pierceable central area. The cartridge assembly comprises a hollow barrel, a pierceable stopper connected to the front portion of the barrel and constituting a compartment in front of said stopper for accommodating the solid, a piston slidably accommodated in the backward portion of the barrel and constituting a compartment for liquid in the barrel, an injection needle longitudinally extending in the liquid compartment, and means for centering the distal end of the needle in order to position the needle tip towards the pierceable stopper. The front cover is capable of rotational movement relative to the outer sleeve to allow the liquid in the barrel to reach the solid compartment through the needle.

Abstract: A prefilled, two-constituent system is provided with first and second containers. The first container includes a first chamber having a dispensing end. The dispensing end defines a dispensing passage communicating through the dispensing end to accommodate the dispensing of fluid from the first chamber. A movable seal is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the dispensing end and the seal. A second container includes a barrel that is sized to be disposed in the first container and that has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the barrel. A plunger is slidably disposed within the barrel. A liquid second constituent is provided in the barrel between the discharge end and the plunger.

Abstract: A parenteral device (10) comprising a body (12) having a forward end (26) and a rearward end (34). The forward end (26) is capable of receiving a hollow retractable needle (20) therein so as to project therefrom. The retractable needle (20) is slidable relative to the body (12) and the body (12) also includes a chamber (14) capable of receiving parenteral fluid and capable of being reduced in volume to expel fluid contained therein. The needle (20) is capable of being manually retracted within the body (12) such that the chamber (14) reduces in volume to expel fluid contained therein and such that the needle (20) is retracted to be wholly contained within the body (12).

Abstract: A system for the sequential and repetitive aspiration and injection of fluid. The system includes a syringe having an internal volume, a piston to vary the internal volume and a chamber divider for separating the internal volume into proximal and distal reservoirs. The chamber divider is moveable along the chamber and is positioned adjacent the distal end of the chamber prior to withdrawal of fluid into the syringe. The proximal reservoir has a maximum displacement volume for receiving fluid. A flow channel provides flow between the proximal and distal reservoirs and a valve disables and enables flow therethrough. A tensile element links the piston and the chamber divider so that after the piston is moved and the proximal reservoir is filled with a first liquid, the chamber divider is pulled away from the distal end of the syringe to enlarge the distal reservoir and draw the blood into the distal reservoir.

Abstract: A device for intermixing a first component, such as a parenteral fluid with a second component, such as an immobilized drug carried by a scaffold to form a beneficial agent which, following the mixing step, can be dispensed directly from the device for infusion into a patient. The device includes novel mechanisms for mateably interconnecting a container, such as a glass vial containing the first component with a housing having a fluid outlet which houses a sealed container containing the second component, and then for controllably mixing the components under sterile conditions to form an injectable solution which is automatically dispensed through the fluid outlet of the device.

Abstract: A dual-chamber syringe has a plunger within an inner delivery chamber in fluid communication with an ejection port. The deliver chamber is formed within a tubular element axially slidable within a tubular guide. The tubular guide and the syringe outer barrel form an outer reservoir chamber. The outer reservoir chamber is sealed from the delivery chamber while the tubular element is in a first position within the guide. Upon withdrawal of the plunger, frictional contact imparted by the plunger seal causes the tubular element to slide away from sealing engagement with the barrel into a second position within the guide. In the second position of the tubular element, a fluid passageway is opened from the reservoir to the delivery chamber allowing fluid to be drawn into the delivery chamber. A porous seal between the plunger rod and barrel allows air into the reservoir during transfer of fluid to the delivery chamber.

Abstract: A double chamber disposable syringe includes a main hollow body having an inner diameter and engaged with an injection needle. A second hollow body is included having an outer diameter smaller than the inner diameter of the main body and having an open lower end and an upper end. The upper end defines a plugging end. A plunger projects through the open lower end of the second hollow body. The second hollow body is positioned between the main body and the plunger. A plug is engaged with the inner diameter of the main body and located adjacent the plugging end. The plug and the plugging end have conduits in substantial alignment wherein the conduit of the plug leads into the main body and the conduit of the plugging end leads into the second body. A cylindrical needle cover extends from the main body and is slidably engaged therewith for enclosing the needle. A sheet means utilized for separating the conduits of the plug and plugging end is positioned between the conduits of the plug and plugging end.

Abstract: A syringe assembly includes a substantially cylindrical syringe barrel and a plunger assembly. The plunger assembly includes a distally disposed flow channelizer and a proximally disposed stopper releasably engaged with one another. The stopper includes an aperture engageable with the distal end of a plunger rod. The flow channelizer includes flutes for accommodating an outflow of vapor during lyophilization and to enable efficient mixing of a lyophilized medication and a diluent. Liquid medication in the syringe chamber is lyophilized and a vacuum is applied to the syringe barrel. The plunger assembly then is urged distally into sealing engagement with the syringe barrel. A plunger rod is engaged with the stopper, and is moved proximally to simultaneously separate the stopper from the flow channelizer and to draw diluent into the chamber for reconstituting the previously lyophilized medication.

Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for controllably ejecting the first component from the glass vial so that it will fall by force of gravity into the second container whereby the first and second components will thoroughly mix under sterile conditions.

Abstract: A drug delivery device (250) is provided for coupling a container (260) including a beneficial agent (262) to the device (250). The device (250) includes a substantially hollow member for housing a solution (256) wherein the hollow member includes an upper section (254) having flexible walls and a lower section (252) having substantially rigid walls. A spike (258) extends from the lower section (252) to provide fluid communication between an interior of the device (250) and the container (260). To this end, the beneficial agent (262) mixes with the solution (256) forming a mixture for administration to a patient. A cannula (266) and a plunger (264) are further provided for administration of the mixture (270) to the patient.

Abstract: An outer tube having a double-ended needle accommodated therein upwardly and downwardly slidably is hermetically, removably but fixedly joined to an opening seal portion of a dissolving liquid container. An inner tube having a medicine-containing vial accommodated therein in an inverted state is joined to an upper end of the outer tube so as to be movable from a joined position of shallow fit to a joined position of deep fit. The joint between the outer and inner tubes is provided with a seal ring for holding the interior of the tubes airtight and a restraining mechanism for holding the inner tube in the joined position of shallow fit. The medicine container thus constructed is excellent in impact resistance and shakeproofness for transport and storage, usable by a facilitated mixing procedure for preparing a medicinal solution, simple in overall structure and disposable as separated into components after use.

Abstract: A method for manufacturing an injectable preparation of a pharmaceutically active agent suitable for storage in a dual-chamber injection cartridge. A dual chamber injection cartridge is provided, including: a barrel; a front chamber for a solid component; a rear chamber for a liquid component; a displaceable front piston separating the front and rear chambers; a closure sealing the front end of the barrel; and a constriction between the front and rear ends of the barrel. The constriction has a non-circular cross-section and an openable bypass connection permitting passage of liquid between the rear and front chambers. Prior to opening the bypass connection, the front piston is positioned between the constriction and the rear end of the barrel. The constriction resists displacement of the front piston in a direction of the front end of the barrel when the piston is in the vicinity of the constriction.

Abstract: A liquid can be dosed advantageously using a syringe-like device, from a container fitted thereon, by means of a plunger mounted displaceably in a dosing chamber, this dosing chamber being connected to the container via a channnel passing through this plunger, a valve and a channel arranged together with the plunger in a connection tube.

Abstract: A catheter access system comprises and integrally molded base sheet which forms first and second opposed slide valve walls. The slide valve walls form an upwardly-open longitudinal valley therebetween. An elongated sliding member is received for slidable movement within the longitudinal valley. A plurality of slide valve inlet ports extend through the first slide valve wall. A slide valve outlet port extends through the second slide valve wall. A plurality of syringes are mounted on the integrally-molded base sheet for fluid communication with the slide valve inlet ports. The elongated sliding member is movable between a plurality of discrete longitudinal positions to individually select slide valve inlet ports for connection to the slide valve outlet port. The sliding member has a plurality of sliding member passageways corresponding to the slide valve inlet ports.

Abstract: A unitary syringe assembly including a diluent syringe and a jell syringe stores and enables convenient transport of isolated components required for injection. A valve is placed between the two syringes. Immediately before required injection, the valve is opened and intermixing injection and reception of the diluent and jell between the two syringes occurs to thoroughly intermix the diluent and jell. The valve aperture size is selected to provide viscous resistance by the jell until thorough mixing has occurred to provide the user with a tactile indication of sufficient mixing. Upon complete mixing, a needle is attached and injection occurs. Paired side-by-side unitary syringes are utilized with an interconnecting mixing manifold with injection occurring from one syringe only to enable higher needle injection pressure.

Abstract: The dual chamber syringe is employed for collecting blood samples. The syringe includes a plunger which is connected to a first piston which, in turn, is connected via a string to a second piston. A passageway is formed in the wall of the syringe barrel to communicate the duct at the forward end of the barrel with the chamber between the two pistons. Thus, upon withdrawal of the plunger from a barrel, fluid flows into the chamber created between the two pistons. Subsequent movement of the two pistons in unison causes a whole blood sample to be drawn into the foremost chamber within the barrel. The syringe can be subsequently connected with a vacutainer via a needle assembly so as to discharge the whole blood sample into the vacutainer for subsequent testing procedures. The discard fluid can be separately dispensed into another container.

Abstract: A two-compartment syringe assembly (10) is composed of a first, outer cylindrical barrel (12), a second, inner cylindrical barrel (14). in which a material (66) is enclosed within a capsule part or ampulla (16) which is received and protected within the second cylindrical barrel, a plunger (18) and a liquid (20), which is enclosed within a first compartment defined within the first cylindrical barrel (12). As the material is concealed within the second cylindrical barrel, any risk of leakage of the material to the environment or atmosphere in case the two-compartment syringe assembly is exposed to shocks, such as mechanical blows, is radically reduced as compared to conventional two-compartment syringe assemblies.

Abstract: An infusion port for subcutaneous placement and dialysis procedures is shown and described as including two chambers, two corresponding large area membrane access panels, and two corresponding barbs providing access between the infusion port and a patient's blood circulatory system. A valve selectively couples the chambers and the barbs in one state, and in another state isolates the barbs and couples directly the two chambers. The valve can operate externally by pressure applied to patient's skin. Hemodialysis is performed in the first state, and in the second state the port is flushed clean of residual blood by injecting cleansing fluid into one chamber and withdrawing it from the other. Also disclosed, an access needle includes a tube carrying a removable penetration pin. The tube fluidly couples to an external barb. The needle is fluidly coupled to the infusion port by driving the needle through the skin of the patient and membrane of the infusion port.

Abstract: Syringe for medical use having two chambers for containing powdered drug and diluent. Its construction is practical and economical, being also disposable.

Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for mixing the components under sterile conditions.

Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for mixing the components under sterile conditions.

Abstract: A device for containing and dispensing a flowable material, for once-only use includes a container, to the delivery mouth of which a cannula can be fitted. The container includes a body and a sealed chamber which are separated by a stopper, which is neutralizable by bending or compressing a deformable portion of the body relative to the sealed chamber.

Abstract: A pharmaceutical mixing container for storing a liquid having at least two factions which tend to separate during storage. A housing has an inner volume and is closed at one end by a septum arrangement and at another end by a combination sealing and pumping member. The combination sealing and pumping member has an integrally formed outer diaphragm element forming a diaphragm chamber with the inner structure of this element, and a plurality of fluid channels extending through the sealing and pumping element from the diaphragm chamber to the surface facing the inner volume of the container. A driving member assembly is coupled to the diaphragm element to enable this element to be extended and retracted by manipulating the driving element assembly inwardly and outwardly of the container.

Abstract: A unitary syringe assembly including a diluent syringe and a jell syringe stores and enables convenient transport of isolated components required for injection. A valve is placed between the two syringes. Immediately before required injection, the valve is opened and the diluent and jell between the two syringes are thoroughly intermixed. Valve aperture size is selected to provide viscous resistance to the flow of the jell until thorough mixing has occurred to provide the user with a tactile indication of sufficient mixing. Upon complete mixing, a needle is attached and injection occurs.

Abstract: An infusion unit has a flexible container and an open-ended pipe having a first opening in communication with the container and a second opening axially opposite the first. The pipe has smaller and larger diameter portions with the smaller diameter portion located between the second opening and the larger diameter portion. An axially moveable plug is receivable within the smaller diameter portion to seal the second opening of the pipe. An axially moveable engaging member with an end for engaging the plug and a needle at the opposite end for piercing the stopper of a vial. The plug may be pushed by the engaging member from the smaller diameter section to the larger diameter section so as to permit flow through the pipe between the first and second openings to the vial and container.

Abstract: A twin-chamber syringe has a pyrogen-free sterile solvent in the chamber averted from the needle, and in the second chamber facing the needle a charge of activity-sensitive human protein, introduced and lyophilized in a single operation in the syringe, where it is stored , in a quantity necessary for therapeutically effective administration. The invention also relates to the filling of the syringe and the potential it offers for immediate use of activity-sensitive human proteins and for self-administration at home.

Abstract: A differential pressure administration set having a tubular chamber, which has an inlet at its upper end connected to a liquid supply container. Below the inlet is a first chamber which receives liquid from the container. Near or at the bottom of the first chamber is an outlet supply line to provide the higher pressure liquid to the operating site. The first chamber also has a second outlet which feeds liquid to a second chamber below the first chamber. There is a second outlet supply line at the lower end of the second chamber, which provides the lower pressure liquid to the operating site. The differential pressure is produced by and corresponds to the difference in height between the levels of the fluids in the first and second chambers.

Abstract: This invention is a carpule-using syringe assembly having a needle protected to minimize the chance of accidental needle-stick. There is a carpule having a pierceable end and a syringe body for receiving and holding the carpule with the pierceable end adjacent an opening in an end portion of the syringe body. A cap is disposed over the pierceable end. The cap includes a support portion disposed in the opening. There are carpule-piercing portions for piercing the pierceable end of the carpule through the cap and a needle having a patient-piercing end. A retractable protective sleeve formed of a plurality of longitudinal slats is disposed over the patient-piercing end of the needle. Finally, there is provision for attaching the needle and the retractable protective sleeve in combination to the support portion with the needle in communication with an interior portion of the carpule through the carpule-piercing portions.

Abstract: A device for intermixing a first component, such as a parenteral fluid with a second component, such as an immobilized drug carried by a scaffold to form a beneficial agent which, following the mixing step, can be dispensed directly from the device for infusion into a patient. The device includes novel mechanisms for mateably interconnecting a container, such as a glass vial containing the first component with a housing having a fluid outlet which houses a sealed container containing the second component, and then for controllably mixing the components under sterile conditions to form an injectable solution which is automatically dispensed through the fluid outlet of the device.

Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely contolled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.

Abstract: A hypodermic syringe has a tubular body extending along and centered on an axis and having at an axial front end a small-diameter collar formed with a front radially outwardly open seat and, axially spaced backward therefrom, a rear radially outwardly open seat. An end piece provided with a deformable plug fittable sealingly in the collar is adapted to receive a needle. Mounting fingers extending axially back from the end piece have rear ends that engage in a front position of the end piece in the front seat and in a rear position of the end piece in the rear seat. The fingers are of such an axial length that the plug is fitted snugly into the collar in the rear position but is not snugly fitted in the collar in the front position. When the end piece is in the front position a medicament in the body can be lyophilized and when in the rear position the syringe is plugged.

Abstract: The present invention provides an improved method and container for filtering a body fluid. The method comprises the steps of isolating a volume of solution in a first chamber of a container; collecting a body fluid in a second chamber of a container; passing the body fluid through a filter; and rinsing the filter with an isolated volume of solution.

Abstract: A two component mixing syringe for mixing and then self-administering a pharmaceutical by injection. A first liquid component is contained within an annular volume between a pair of coaxial housings. A pair of sealing bands defines the upper and lower boundaries of the annular volume. The lower sealing band is located above an aperture communicating with the inner housing interior. A driving sleeve is mounted with a driving end resting on the upper sealing band, the sleeve being located in the annular space between the two housings. Downward motion of the sleeve forces the upper sealing band downwardly causing the liquid component to drive the lower seal downwards past the cross bore. Thereafter, the liquid is free to flow through the cross bore and mix with the second component in the interior of the inner housing element.

Abstract: A suction drainage control system that reduces an operator's exposure to infectious waste by permitting waste-treating material to be dispersed into a sealed chamber in which the infectious waste is contained. The sealed chamber includes a cover with a flexible liner sealed to and suspended therefrom. A reservoir having a closure is provided inside the sealed chamber for storing the waste-treating material, which reservoir is opened by manipulating the flexible liner to remove the closure.

Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.

Abstract: The present invention is addressed to providing an infusion administration container which is effective in establishing about a normothermic temperature of a physiologic solution for its infusion into an animal, such as a human medical patient. The infusion administration container comprises an upper flexible bladder adapted to contain at least one first chemical agent and a first lower flexible bladder adapted to contain at least one second chemical agent. These first and second chemical agent(s), when combined, result in an exothermic reaction. A passageway interconnects the upper bladder and first lower bladder with manually openable closure means disposed within the passageway to separate the chemical agents until the closure means is opened. A second lower flexible bladder, adapted to contain an administrable physiologic fluid, is disposed in heat-exchange relationship with the first lower bladder.

Abstract: A suction drainage control system that reduces an operator's exposure to infectious waste by permitting waste-treating material to be dispersed into a sealed chamber in which the infectious waste is contained. The sealed chamber includes a cover with a flexible liner sealed to and suspended therefrom. A freely movable reservoir is provided inside the sealed chamber for storing the waste-treating material, which reservoir is opened by manipulating the flexible liner to open the reservoir.

Abstract: An improved diluent container having a small elongated wand (made of plastic or similar material), designed to secure a drug vial cap in place and simultaneously obstruct an I.V. port in a diluent bag similar to an ADD-VANTAGE flexible diluent container. The device is actuated by grasping a gripper ball portion located approximately midway down the wand shaped plug from outside the I.V. bag and removing the vial cap end from the discharge opening between the vial, holding medicament, and the flexible diluent container. Once the vial capped end is removed, the medicament enters the diluent and is mixed by shaking or squeezing the flexible diluent container while maintaining the other end of the wand in the I.V. port. The device has a length which is designed so that the end of the wand shaped plug cannot be removed from the I.V. port of the flexible diluent container until the end blocking the drug vial has been removed from that opening. This thereby prevents the inadvertent administration of I.V.

Abstract: A bottle is provided with a dislodgeable container to hold two components of a medicament free of contact with each other until mixing is desired. One component may be a solid and the other a liquid, or both may be liquids. Mixing is accomplished by removing a locking ring and depressing the holder means.

Abstract: A terminal reservoir capping device according to the present invention includes a hollow member having first and second open ends. A first plug seals the first open end such that the plug is inwardly displaceable into the hollow member. A second plug seals the second open end. A chamber is defined by the hollow member and the first and second plugs. A reservoir of disinfecting fluid or therapeutic drug is provided in the chamber. Axially extending from the first end of the hollow member is a mechanism for engaging and advancing the tube connector into the chamber so as to inwardly displace the first plug into the chamber. The plug self-releases and allows dispersal of the reservoir fluid into the tube connector.

Abstract: A flexible container is provided for the storage and mixing together of diluents and medicaments. The container incorporates multiple compartments, separated by frangible seals, in which the diluents and medicaments are stored. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through a standard IV arrangement to a patient.

Abstract: A twin-chamber syringe has a pyrogen-free sterile solvent in the chamber averted from the needle, and in the second chamber facing the needle a charge of activity-sensitive human protein, introduced and lyophilized in a single operation in the syringe, where it is stored, in a quantity necessary for therapeutically effective administration. The invention also relates to the filling of the syringe and the potential it offers for immediate use of activity-sensitive human proteins and for self-administration at home.

Abstract: A drug dispenser comprising a drug vial to whose neck a hollow spike is attached for insertion into a diluent container, with a jaw around the spike grasping the inlet port of the container. A stopper seals the vial's throat, and a two-way value covers its mouth. The valve is opened, and the stopper is blown from the vial's throat by squeezing the diluent container, thereby sending diluent under pressure through the hollow spike, the open valve, and the unobstructed throat into the vial.