Abstract: A system is provided for the storage and injection of a beneficial agent. The system includes a barrel, the barrel having a loading end and a distal end, and a piston having an elastomeric portion slidably disposed in the barrel bore. A receptacle pre-filled with the beneficial agent is loaded into the loading end of the barrel and is movable with the piston. A tubular flow connector is carried by the piston for connecting the receptacle to a distal chamber of the barrel so that the agent can flow from the storage receptacle into the distal chamber when the piston is retracted away from the distal end of the barrel. A structure is provided along a portion of the receptacle to allow the agent to flow from the receptacle, through the flow connector and into the distal chamber without being inhibited by the development of negative pressure within the receptacle.

Abstract: An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a fill assembly comprising a prefilled vial that can be used to fill the fluid reservoir of the device with a selected medicinal fluid.

Abstract: A syringe, of the type having two variable volume chambers inside the main cylindrical body, said chambers being separated by a displacing valve assembly, and being capable of housing components which should be mixed prior to injection. The novelty resides in the special conformation of parts and elements constituting said valve assembly, which comprises two cooperating, displacing elastomer portions; one of said portions being comprised by a peripheral, hollow cylindrical body bearing on the cylindrical wall of the main body, the other portion being an inner, solid cylindrical body slidingly bearing on the inner face of the front portion.

Abstract: A syringe is modified to permit gradual administration of its contents with reduced problems due to seizing or stiction of its piston by dividing its piston axially into two parts, a front detached part and rear part which is the only part having provision for attachment to a syringe actuator. The rear part has a passage through which fluid can be gradually introduced from an actuator into a chamber between the parts so as to force the front part forward while the rear part is restrained against rearward movement. The passage may be initially closed by a septum which is penetrated by a cannula on the actuator. If the syringe actuator is a plunger, the syringe can be used conventionally.

Abstract: A vial comprises a tubular syringe barrel (1) closed at one end (2) and open at the other, a stopper in the open barrel end formed by a piston head (4) of a syringe, and valve means (10) in the barrel between the stopper and the closed barrel end. The valve means (1) is normally closed and actuatable to an open condition by movement of the stopper into the barrel, and is slidable with the piston head (4) to the closed barrel end (2).

Abstract: A prefillable syringe includes an elongate barrel having an open distal end and a proximal end with at least one chamber formed therebetween for receiving a substance sensitive to pH shift, such as water for injection. The barrel is made of a low extractable ion glass preferably having a low concentration of sodium of less than 8% and preferably around 4% or less.

Abstract: A dual chamber syringe for dispensing a dry medicine that is to be reconstituted just prior to administration to a patient includes a syringe housing having an outer wall and proximal and distal end portions. A syringe bore extends between the proximal and distal end portions. The bore is divided during use into upper and lower chambers for containing medicinal contents that are to be first mixed and then dispensed. In the preferred embodiment, the chambers contain an upper liquid component and a lower dry component. A first lower piston occupies a position generally in between the upper and lower chambers. The first lower piston engages a plurality of ribs at an enlarged diameter bypass portal section of the syringe housing with multiple longitudinally extending channels after the user applies pressure to a second upper piston in the bore and above the upper chamber. Continued downward movement of the two pistons causes the two components to mix to be dispensed from the distal end of the syringe.

Abstract: A two-compartment type prefilled syringe includes a first rubber stopper fitted into a front sleeve, a second rubber stopper fitted into a rear end portion of a cartridge, a third rubber stopper for hermetically dividing the interior of the cartridge into front and rear compartments and a bypass formed by radially outwardly bulging a portion of a peripheral wall of the cartridge. In an axial direction of the cartridge, a length of the third rubber stopper is slightly smaller than an inner length of the bypass. When the third rubber stopper has been displaced into the bypass, the sealing property of the rear compartment with the front compartment is cancelled such that the dissolving agent, suspension or the like in the rear compartment is carried, via the bypass, into the front compartment containing dry medicament or the like.

Abstract: A device for displacing a plunger (35), movably disposed in a container (23), e.g. a medical multi-chamber ampoule, which has at least one movable partition (29), sealingly isolating at least two substances to be mixed with each other, comprises a holder means (6) for releasable connection to the container (23), a screw actuator (4) engageable with the plunger (37) for displacing it in the container (23), the holder means (6) further having a female thread, engageable with the corresponding male thread of the screw actuator. The female thread is divided into at least two parts, which are movable between a first position, in which the parts of the female thread are not engageable with the screw actuator, and a second position, in which the parts of the female thread are engageable with the actuator. The bolder means (8) has actuating means for moving the female read parts between said first and second positions.

Abstract: A liquid dispensing infant pacifier has a mouth guard with a hollow tubular connector portion on its rear side over an opening extending through the mouth guard from its rear side to its front side. The connector has a configuration similar to that of a catheter hub and is selectively and removably connectable to either the interiorly threaded discharge end of a conventional liquid dispensing syringe or a closure cap portion of the pacifier which serves to block fluid flow through the connector portion. Projecting outwardly from the front side of the mouth guard, over the opening therein, is a specially designed double-walled tubular nipple which is formed from a partially everted pliable material tube and has a large interior flow space extending outwardly through the open front end of the nipple body.

Abstract: A syringe in which one or more injectable materials are filled, comprises a cylinder or barrel in which a front partition stopper, which can be fixed or movable depending on the embodiment, and one or more intermediate partition stoppers are slidably disposed. In the simplest arrangement, a single intermediate partition stopper is disposed between the front partition stopper and a rear piston, to define first and second chambers within the cylinder in which first and second injectable materials can be respectively filled. An outer periphery of the intermediate partition stopper is provided with a plurality of circular lips between which at least one peripheral groove is defined. One of the first and second chambers is communicated with peripheral groove or grooves of the intermediate partition stopper by small passages to allow the first medicine, which is in liquid form, to enter and fill the groove or grooves and exclude air and bacteria therefrom.

Abstract: An injection cartridge is disclosed which has provision for the after injection of a rinsing solution to wash off the medicament that is first injected. The novel cartridge has a forward compartment and a rearward compartment, each having a piston disposed rearwardly thereof. A by-pass conduit is provided at the forward end of the cartridge which is longer than the thickness of the forwardmost piston. A medicament is positioned in the forward compartment and a rinsing solution is positioned in the rearward compartment. Moving the rearward piston forward forces the rinsing solution against the forward piston which in turn forces the medicament forward and expels it from the forward compartment. After the forward piston has reached its forward stop, the forward by-pass becomes open to the rearward compartment and continued forward movement of the rearward piston causes the rinsing solution to be forced through the forward by-pass and out the outlet end of the cartridge.

Abstract: Disclosed is a flow control device for use with an intravenous set to control the flow of medicinal fluid in a barrel into patient's body. The flow control device comprises a floating member capable of being supported for floating by the buoyancy of the medicinal fluid and having a first hollowed portion facing upwards so that the hollowed portion can contain medicinal fluid and a second hollowed portion facing downwards. A linkage bar is secured to the floating member by insertion into the second hollowed portion. A membranous member is coupled via the linkage bar to the floating member such that the membranous member moves along with the floating member.

Abstract: Prefilled syringe for injection of two liquids includes a syringe body with an injection port at a closed end thereof, first and second gaskets fluid-tightly fitted into the syringe body to separate two medical solutions filled therein, and a closing member for closing the injection port. The syringe body is provided with bypassing grooves extending in the longitudinal direction of the syringe from a position adjacent to the closed end thereof. Liquid communication means is provided between the closed end and the first gasket. By pushing a plunger, the first and second gaskets are forced to move forward so that two medical solutions are injected one after another.

Abstract: An in situ reconstitutable biological ampoule package is provided which includes an open-ended container having non-frangible, deformable wall structure for receiving a quantity of lyophylized bacteria. An ampoule within the container stores a quantity of a liquid medium for reconstituting the bacterial product. Application of pressure to the ampoule by squeezing of the container effects deformation of the side wall of the ampoule thereby releasing the liquid for reconstitution of the biological product. The ampoule may be either of glass which breaks when subjected to pressure, or of synthetic resin material which collapses when squeezed, thereby causing the stored liquid to be ejected from the ampoule through an aperture in the side wall thereof. A dropper cap closing the open end of the container allows the user to apply the reconstituted bacterial product in a drop-wise fashion to a target medium.

Abstract: A syringe device for use with two components to be combined prior to discharge, comprising a syringe body without the proximal end, a syringe plunger rod threadedly engageable into a plunger and a lined seal for engagement with a needle hub. The syringe body has at the distal end a radially inwardly directed internal sealing ring dividing the body to define a distal chamber and a proximal chamber. Also provided is an internal bypass stopper sized to fit the syringe body and engage the sealing ring to sealingly separate the distal chamber and the proximal chamber. The stopper has a plurality of projections circumferentially spaced thereon for engagement with the syringe body on at least one side of the sealing ring. The projections define by-pass channels therebetween to permit flow of liquid from the proximal chamber to the distal chamber upon movement of the stopper toward the distal end.

Abstract: A syringe outer cylinder is split into a front chamber outer cylinder and a rear chamber outer cylinder. Powdered medicine is sealed in a sterilized state in the front chamber outer cylinder. Liquid medicine is sealed in a sterilized state in the rear chamber outer cylinder. Thereafter, the front chamber outer cylinder is coupled to the rear chamber outer cylinder with a coupling component, and the dual chamber prefillable syringe is assembled. Therefore, sealing of powdered medicine and liquid medicine can occur in parallel.

Abstract: The invention relates to an injection syringe for mixing and applying injection substances having a syringe cylinder and a plunger displaceable therein. The plunger has a stopper at its distal end tightly engaged against the inner surface of the cylinder to form an injection volume in the syringe cylinder. A mixing plunger is displaceable in longitudinal direction and guided through the plunger. The mixing plunger projects from the stopper at its proximal end and, at its distal end, has a mixing piston with at least one opening, passing through the surface of the piston. Injection substances can pass through the one opening when the mixing piston is displaced in the injection volume. An effective thorough mixing of the injection substances takes place through to-and-fro movement of the mixing piston in the injection volume.

Abstract: In medical scenes requiring emergency, where plural medicines are to be injected simultaneously, or solution of solid medicine is to be injected, different kinds of injection agents, without being previously mixed, are accommodated in chambers formed separately in a cylinder. In using a syringe, both injection agents can be sequentially injected separately or mixedly by a simple operation.

Abstract: An elastomeric drive line coupling. The coupling includes an input drive shaft having a longitudinal axis and terminating at one end with a housing and an output drive shaft having a longitudinal axis and terminating at one end with a ball. The housing has a partially elliptical interior and the ball has a partially elliptical exterior which is disposed within the housing. A partially elliptical rigid shell is provided between the ball and the housing. Both the ball and the rigid shell are bonded with elastomeric layers forming interleaved nested ellipses within the housing. These ellipses are oriented 90.degree. out of phase from one another. Torsional loads are applied to the output drive shaft by the input drive shaft through compression deformation of the elastomeric layers as the partially elliptical rigid shell attempts to rotate relative to the housing and the ball.

Abstract: A removable manifold assembly for attachment to the outlet end of a multi-cartridge injection device. The manifold assembly comprises two rigid plastic housings which encapsulate a rubber septum. Check valves are formed by compressing the front surface of the septum against a seal face of the rear housing to form a fluid tight interface therebetween. A first fluid path is formed from each cartridge in the injector through the manifold assembly to a patient delivery needle. A second fluid path is formed in the manifold assembly from the first fluid path to a back surface of the septum in order to enable a residual fluid force to be exerted against the back surface of the septum, thereby forcing the respective check valve in its closed position. The manifold assembly includes a unique geometry that permits the manifold to be snapped into engagement with the housing only when properly oriented with the housing.

Abstract: A flexible, sterile container is provided for sterile storing and mixing of medicaments and liquids which includes a shell with at least one compartment. At least one sterile liquid-containing pouch is in one of the compartments, and a medicament is in the compartment with the pouch or is in a different compartment. The liquid and medicament are mixed together by squeezing the shell and pouch to rupture the pouch to release the liquid for mixing with the medicament just prior to dispensing the mixture.

Abstract: A hand held syringe has a stationary handle and a moving handle to enable both stored and transported pharmaceuticals to be mixed and injecting the mixed pharmaceuticals under high pressure immediately after mixing through a long needle to a site interior of the body. The syringe is provided for squeeze grip at the stationary and moving handles between fingers and palm and includes a jell storage chamber side-by-side with a diluent storage chamber. Upon initial compression of the handles towards one another against a spring bias, the diluent discharges to the jell mix chamber along a one way path. At the same time, a handle actuated piston with loosely fitting O-ring in the jell mix chamber moves through the jell and introduced diluent effecting mixing movement by allowing the jell and diluent to flow between the piston and jell chamber sidewalls. Flow occurs from the jell chamber by the piston to an expansible chamber delimited by a floating seal.

Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for mixing the components under sterile conditions.

Abstract: A dispenser (2) includes a body (4), a needle (110) and one or more hollow cylinders (28) and pistons (144). The needle is movable between predelivery position and a delivery position, at which the inner needle end (112) opens a ball check valve (142) to permit free fluid flow from the cylinder, along a flow path (46) and through the needle. A threaded dose adjuster (164, 166) is mounted within the body and engages a threaded stem (150). The stem is prevented from rotating so that a rotation of the dose adjuster in one direction causes the dose adjuster to move axially away from the piston to compress a drive spring (176) and preload the stem. Moving the needle assembly to the delivery position causes the dose of pressurized pharmaceutical to be automatically driven from the cylinder and through the needle. The cylinder can be refilled by the user through the needle by opening (88, 92, 94) a supplemental pathway (54, 52) and rotating the dose adjuster in the opposite direction.

Abstract: A vial (2, 202) has first and second chambers (56, 232; 54, 234) initially separated by a rupturable barrier (20, 212). The first chamber is a variable volume chamber defined by a cylinder (18, 208), the rupturable barrier at the second end (19, 214) of the cylinder and a piston (14, 228). The second chamber is created by a telescoping container (22, 226) mounted to a second end of the cylinder. The chambers are telescopically collapsed causing fluid pressure in the second chamber to rupture the barrier so the components mix in the first chamber. The piston is driven through the cylinder from pre-mix to post-mix positions by the liquid from the second chamber. This dislodges a safety shield (30, 226) at the first end of the cylinder to expose the piston.

Abstract: A two component mixing syringe for mixing and then self-administering a pharmaceutical by injection. A first liquid component is contained within an annular volume between a pair of coaxial housings. A pair of sealing bands defines the upper and lower boundaries of the annular volume. The lower sealing band is located above an aperture communicating with the inner housing interior. A driving sleeve is mounted with a driving end resting on the upper sealing band, the sleeve being located in the annular space between the two housings. Downward motion of the sleeve forces the upper sealing band downwardly causing the liquid component to drive the lower seal downwards past the cross bore. Thereafter, the liquid is free to flow through the cross bore and mix with the second component in the interior of the inner housing element.

Abstract: A syringe for sequentially injecting a plurality of liquids into an intravenous (IV) infusion component that has a connector fitting includes a syringe vessel having a preferably needleless injection port that is engageable with the connector fitting of the IV component. A syringe plunger is slidably disposed in the syringe vessel, and at least one barrier plunger is slidably disposed in the syringe vessel between the injection port and the syringe plunger. The barrier plunger is formed with a pathway for fluid communication therethrough, and a valve is positioned in the pathway of the barrier plunger to block fluid communication through the pathway. A nipple extends inwardly from the injection port for opening the valve of the barrier plunger when the barrier plunger is urged against the nipple. A first liquid is disposed in the syringe vessel between the barrier plunger and the injection port and a second liquid is disposed in the syringe vessel between the two plungers.

Abstract: A multiple pharmaceutical syringe (2, 160, 402), especially useful for use in dispensing insulin, includes a body (4, 162, 404) housing first and second pharmaceutical-filled cartridges (30, 32; 182, 184; 478, 480). The cartridges are of the type with a septum (36, 190, 484) at one end and a piston (42, 48; 224, 225; 562, 564) at the other end with the liquid pharmaceutical (46, 48; 226, 228; 534, 536) between the two. The body also defines an accumulator chamber (10, 202, 654) within which an accumulator piston (26, 238, 464) is slidably mounted. The cartridge interiors are connected by a flow path (70, 752) to the accumulator chamber. Pressing on the cartridge pistons forces desired amounts of the liquids from the cartridge into the accumulator chamber. The mixed pharmaceutical is dispensed by driving the accumulator piston.

Abstract: The present invention is a two-compartment syringe which may contain a medical substance, such as a freeze-dried powder, and a solvent separately. When used, the medical substance and solvent are mixed for injection. A silicone coating is used inside the syringe barrel. The syringe is further provided with finger hooks to enable use of the syringe with one hand.

Abstract: A multipharmaceutical delivery system, such as a syringe (2) or a topical pharmaceutical applicator, suitable for a simultaneous delivery of a mixture (124) of two or more mixed pharmaceuticals (52, 120) in selected amounts and proportions, includes a body (4, 180) with first and second variable volume reservoirs (24, 26), containing the first and second liquids or other flowable materials, such as creams and salves. The reservoirs are connected to a variable volume accumulator chamber (31) through check valves (28) to permit liquid to flow from the reservoirs into the accumulator chamber but not the reverse. A delivery head, such as a needle assembly (78) or a spray nozzle assembly (196), is selectively fluidly coupled to the accumulator chamber by an exit path (106, 202) formed in the body.

Abstract: A dosing assembly (80) is used to controllably fill a syringe (4), held within a syringe holder (50), from a vial (2) of the type including a piston (18) mounted within a container (14). The syringe holder (50) is threadably mounted (52, 36) to the vial with the needle cannula (72) piercing the piston to permit the syringe holder to be driven against the piston in a controlled manner to accurately meter the pharmaceutical introduced into the syringe. The dosing assembly includes a rotary drive (82, 88, 110, 118, 126) which rotates the syringe holder about the syringe holder axis, thus driving the syringe against the piston, as the syringe holder and syringe therewith are rotated about an axis situated 90.degree. from the syringe axis. This causes the pharmaceutical within the vial to be forced through the needle cannula and into the syringe; the amount of the dose in the syringe depends upon how far the user rotates the syringe holder using the rotary drive.

Abstract: A multiple inlet manifold for mixing and transporting therethrough fluids under pressure comprising a manifold body including a plurality of valve inlets and a single outlet, a mixing chamber provided between the valve inlets and the outlet, and a flexible membrane disposed between the valve inlets and the outlet to retain the valve inlets normally closed at selected levels of fluid pressure. Fluid flow under pressure opens a valve inlet to enable fluid flow into the mixing chamber.

Abstract: A drug infusion manifold for controlling the infusion of drugs and/or other solutions into an intravenous patient feed line. The manifold includes a housing defining an elongated in-line flow channel that communicates at one end with a carrier fluid inlet line and at the other end with the patient feed line. A plurality of spaced apart drug inlet openings are formed in the housing in communication with the flow channel. Each of the inlet openings is provided with a check valve assembly that includes a valve member defining an inlet socket portion and a valve stem portion that extends into the flow channel. The valve stem portion has a cylindrical side wall that defines an inlet passage that communicates with the socket portion. A plurality of lateral inlet ports extend through the side wall. An elastic sleeve member is received about the valve stem portion in covering relationship with the inlet ports. The valve stem portion is in-line with the flow of carrier fluid through the flow channel.

Abstract: A preparation administrator has an administrator body including a solid preparation and having at its one end an inflow channel for solvent and at the other end an outflow channel for liquid preparation, a solvent container containing a solvent to dissolve, disperse or suspend the preparation and being connected to the inflow channel of the administrator body, and an ejector for ejecting the solvent together with the solid preparation in the body through the outflow channel of the body. A solid preparation in the administrator body is dissolved, or suspended or dispersed in the solvent fed from the solvent container and ejected as a liquid preparation through the outflow channel of the body.

Abstract: A drug dispenser comprising a drug vial to whose neck a hollow spike is attached for insertion into a diluent container, with a jaw around the spike grasping the inlet port of the container. A stopper seals the vial's throat, and a two-way value covers its mouth. The valve is opened, and the stopper is blown from the vial's throat by squeezing the diluent container, thereby sending diluent under pressure through the hollow spike, the open valve, and the unobstructed throat into the vial.

Abstract: The invention relates to a plural-compartment dispenser for storing and mixing several components at least one of them a liquid, and in particular to a dispenser comprising a barrel, a plunger, a needle or means to connect same, finger grip or means to connect same, a stopper placed in the barrel between the needle and the plunger, said stopper having a hollow dilated central cavity open proximally and distally by apertures, said proximal aperture being releasably sealed by a bounded or fitted pressure activated blow plug.

Abstract: A component mixing syringe (2) is used to mix a liquid component (94) with a solid component (96) prior to use. The syringe includes a barrel (4) having a bore (10) with a plunger (20) at one end and a needle (54) at the other. A barrier (14) divides the bore into a far region (16) and a near region (18). The far region is divided into variable volume liquid and air compensating regions (88, 90) which contain the liquid and dry components. The plunger is partially withdrawn from the near region to create a partial vacuum. A pathway formed through the barrier is opened to permit the liquid to rush into the near region to create a relatively violent, turbulent mixing action to effectively mix the two components. The mixing can be further enhanced by moving the plunger along the bore forcing the mixture back and forth between the near and far regions.

Abstract: A medical fluid administration set is disclosed which may be used for the passive reconstitution and delivery of a drug or other beneficial agent with liquid flowing through the administration set. A receptacle mounted in the administration set is adapted for receiving a cartridge containing the beneficial agent. Also disclosed is an adapter for connecting the cartridge and the receptacle and an air flask within the administration set.

Abstract: A device for dispensing liquids, in particular drugs, comprises a reservoir (11) provided with a neck (30) of reduced cross-section being engaged by a stopper element (16). The reservoir is completely covered by a cap (25) which has at one end a movable push button (28) which abuts against the bottom portion of the reservoir (10). In order to transfer the device from its storage position to its activated position, the operator must press on the push button (28) in such a way that the stopper element (16) penetrates into the interior of the reservoir beyond the neck of reduced crosssection (30). This device can be used as an injection syringe, a spray dispenser, or an applicator for the skin or eyes.

Abstract: Disclosed is a two compartment syringe having at least two by-passes which selectively allow an easy flow from one compartment to the other compartment.The liquid (injection fluid) is in the "needle" compartment and the solid medicament is in the "plunger" compartment. Associated with the plunger compartment is an aperture or other means for allowing the escape of fluids from that compartment during a lyophilization process.

Abstract: A package comprising a package container structure having an open end leading into an interior chamber therein, a package lid structure mounted over the open end of the package container structure in generally sealed relation with the interior chamber thereof so as to be moved into opening relation thereto, and a device for use with a medicament vial disposed within the sealed interior chamber. The device and package container structure have interengageable elements disposed out of interengagement when the device is disposed within the sealed interior chamber operable when the package lid structure is moved into opening relation and the device is moved out of the open end of the interior chamber to be moved into interengagement. The device and package container structure with the interengaging elements thereof interengaged provide a generally sealed interior space including the interior chamber within which a medicament vial is contained in cooperating relation with the device.

Abstract: A dual-chamber cylinder ampoule is used for the mixture of a sensitive, solid medicament, with liquid which is caused to flow calmly through the medicament in order to avoid any shaking and mechanical influence. The mixing is preferably carried out at a pressure above atmospheric.An injection device for the preparation of an injection solution and a following injection of such solution includes first and second tubular members for enclosing and holding a dual-chamber cylinder ampoule, in which the dry medicament is kept separated from the liquid. When the two tubular members are being screwed together the liquid is calmly and gently mixed with the dry medicament and dissolves it, and the resulted solution can thereafter be injected by means of the dosage and administration mechanism, provided in one tubular member, through a needle arranged at the front end of the other tubular member.

Abstract: A syringe for hypodermic injection wherein multiple pistons seal various number of chambers. One piston provides the basic operating force to dispell the contents from a chamber or successive chambers and another piston or other pistons forming a chamber or additional chambers permitting release of the chamber contents or successive chamber contents and a syringe holder for holding, using and disposing of the syringe minimizing potential of accidental sticking by the needle of the syringe.

Abstract: A syringe for dispensing a liquid pharmaceutical composition has a first chamber (5), adjacent to nozzle (3), which contains a mositure sensitive solid drug, two movable septa (8,9) which together create a second chamber (6) and a third chamber (7) holding a liquid diluent, and a liquid by-pass passage (19) which can connect the third chamber (7) to the first chamber (5) while by-passing second chamber (6).A plunger (4) is depressed to move the septum (9) towards the nozzle (3), thereby causing liquid diluent to flow via by-pass passage (19) into the first chamber (5) to mix with the drug.The second chamber (6) contains moisture sequestering material to insulate the drug from any moisture which might leak through septum (9).

Abstract: A method of utilizing an apparatus of the type comprising a vial container hazardous material in the vial container in a condition requiring a diluent to be mixed therewith to form the liquid solution, and an assemblage carried by the vial container for providing (1) a sealed medicament chamber within the vial container within which the hazardous material is disposed, (2) a filter vented control chamber and (3) a sealed variable volume control chamber between the vented control chamber and the medicament chamber. The method is such as to enable an open end of a syringe needle of a diluent syringe having a syringe chamber containing diluent in communication therewith to be moved into and withdrawn successively from the chambers so as to mix the diluent with the hazardous material. The method also contemplates procedures for separately refilling a dosage syringe and for relieving any residual pressure in the vial chamber with the use of an empty syringe prior to initial or final refilling of a dosage syringe.

Abstract: An automatic injector for injecting one or more different injection liquids, comprising a combination of a substantially cylindrical means containing a discharge mechanism and a plurality of cartridge elements. The cartridge elements comprise a piston in the substantially cylindrical means, a sealing stopper, a number of separating stoppers equal to one less than the number of the liquids, and a needle holder with injection needle. The needle holder comprises a stopper that is movable in the substantially cylindrical means and comprises a longitudinal bore. The injector comprises a by-pass means for injection liquid in front of the sealing stopper.

Abstract: The invention relates to an automatic injector for injecting one or more injection liquids, comprising an assembly of a discharge mechanism, a cartridge in a cartridge holder, and an outer sleeve which is telescopically slidable around the cartridge holder, which cartridge comprises a barrel, in the barrel a piston and a number of separating stoppers equal to one less than the number of injection liquids, a needle holder with injection needle and optionally a by-pass for injection liquid. The injector is suitable for accommodating a solid and a solvent therefor, and for that purpose comprises a passable stopper between solid and solvent and a solvent by-pass in the barrel wall or in the passable stopper, in which, by a single or repeated operation of telescoping external parts of the injector solvent can pass the passable stopper and can reach the solid, as a result of which the injector can be made ready for use.

Abstract: The invention relates to a multi-compartment syringe comprising an ampoule having a plunger, a sealing stopper and at least one separating stopper between the plunger and the sealing stopper, and a needle holder consisting of a collar, a neck for an injection needle, a shaft between the collar and the neck and a by-pass means in the inner wall of the shaft, the space in the shaft of the needle holder being at least slightly longer than the sealing stopper, the ampoule wall comprising a liquid by-pass means through which the liquid behind the separating stopper or stoppers can reach the substance in front of the separating stopper or front separating stopper and can mix with same or can dissolve it, the ampoule, before use of the syringe, comprising an empty space in front of the sealing stopper.

Abstract: An arrangement for applying a tissue adhesive based on human or animal proteins, to seamlessly or seam-supportingly connect human or animal tissue or organ parts by uniting with blood-clot-promoting coagulation factors (thrombin). The arrangement includes a plurality of syringe bodies commonly actuatable by pistons and to which a connecting head is attachable. The syringe bodies have equal effective strokes, yet one of them, i.e., that destined to contain the protein solution, has a cross sectional area that is two to nine times larger than the other one(s). There may be applied tissue adhesives having a fibrinogen content of from 2 to 12%.