Including Natural Bone Tissue Patents (Class 623/23.63)
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Patent number: 7670384Abstract: Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.Type: GrantFiled: April 19, 2006Date of Patent: March 2, 2010Assignee: Biomet Manufacturing Corp.Inventors: Mukesh Kumar, Ned M. Hamman, Michael D. Leach, John Manocchio, Paul D'Antonio, Daryl L. Carter
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Patent number: 7662184Abstract: A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.Type: GrantFiled: February 19, 2007Date of Patent: February 16, 2010Assignee: Osteotech, Inc.Inventors: Jean T. Edwards, Lawrence A. Shimp, Michele Diegmann, Todd M. Boyce, Nelson L. Scarborough, James L. Russell
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Publication number: 20100036503Abstract: The invention is directed to a process for making a tissue repair implant having a porous sponge-like structure to repair bone, cartilage, or soft tissue defects by producing a connective tissue homogenate from one or more connective tissues; mixing the connective tissue homogenate with a carrier solution to produce a connective tissue carrier; optionally mixing one or more natural or synthetic bone fragements with said connective tissue carrier to produce a tissue repair mixture; freezing or freeze-drying the tissue repair mixture to produce a porous sponge-like structure and create a three-dimensional framework to entrap the natural or synthetic bone fragments, treating the frozen or freeze-dried porous sponge-like structure with one or more treatment solutions to produce a stabilized porous sponge-like structure. A crudely fragmented connective tissue from one or more connective tissues is optionally mixed with the tissue repair mixture before freezing or freeze-drying.Type: ApplicationFiled: August 7, 2008Publication date: February 11, 2010Inventors: Silvia S. Chen, Jingsong Chen, Lloyd Wolfinbarger, JR.
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Patent number: 7658768Abstract: Bone graft substitute compositions and methods of making the compositions are disclosed. In some embodiments, a method of making a composition includes contacting a mixing solution with a first mixture having calcium sulfate hemihydrate and a plasticizing material to form a second mixture; waiting a predetermined period of time after forming said second mixture; and then contacting demineralized bone with the second mixture to form the composition. A composition can be formed from a kit including a first mixture having calcium sulfate hemihydrate and a plasticizing substance, a second mixture having demineralized bone, and a mixing solution. The first and second mixtures and the mixing solution are unblended.Type: GrantFiled: October 15, 2007Date of Patent: February 9, 2010Assignee: Wright Medical Technology, Inc.Inventors: Leasa C. Miller, Kelly Coupe Richelsoph, Jon P. Moseley
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Publication number: 20100015202Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.Type: ApplicationFiled: July 24, 2009Publication date: January 21, 2010Inventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine Gomes Truncale, Judith I. Yannariello-Brown, Yen-Chen Huang
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Publication number: 20090312842Abstract: Bifunctional and assembled implants are provided for osteochondral implantation.Type: ApplicationFiled: June 16, 2008Publication date: December 17, 2009Inventors: Predrag Bursac, Lauren M. Brown, Eric J. Schmitt, Guy B. Grover
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Patent number: 7621963Abstract: A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed.Type: GrantFiled: April 11, 2006Date of Patent: November 24, 2009Assignee: EBI, LLCInventors: Bruce J. Simon, Robert M. Ronk, Paul D'Antonio, Jeffrey D. Schwardt
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Patent number: 7608113Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.Type: GrantFiled: November 24, 2003Date of Patent: October 27, 2009Assignee: Synthes USA, LLCInventors: Michael L. Boyer, II, David C. Paul, Christopher M. Angelucci
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Publication number: 20090265017Abstract: A bone graft substitute includes a porous matrix at least partially covered by a reinforcing outer layer. The porous matrix may be a collagen-ceramic composite, and the reinforcing outer layer may be formed from highly cross-linked collagen. The implant may also include one or more reinforcement ribs, which may be made from calcium phosphate or dense collagen. In addition, the bone graft substitute preferably includes an effective amount of a bioactive agent, such as BMP-2, rhBMP-2, or functional fragments thereof. The bioactive agent is preferably disposed within the porous matrix.Type: ApplicationFiled: April 17, 2008Publication date: October 22, 2009Applicant: Warsaw Orthopedic, Inc.Inventor: William F. MCKAY
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Publication number: 20090210057Abstract: A multi-layered matrix, a method of tissue repair using the same, and multi-layered implant prepared thereof are provided. The multi-layered matrix comprises a first element and a second element connected thereto, and the second element comprises a hollow cavity. The first and the second elements are composed of a composite material comprising a bioabsorbable porous material.Type: ApplicationFiled: April 20, 2009Publication date: August 20, 2009Inventors: Chun-Jan Liao, Ching-Chuan Jiang, Hong-Sen Chiang, Yu-Ru Lin
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Publication number: 20090187245Abstract: The invention is directed toward a sterile composite bone graft for use in implants comprising a central member constructed of biocompatible plastic with two end caps of cortical bone mated to opposite ends of the central member. The central member is cylindrically ring shaped with a plurality of ribs formed in the side wall of the cylinder.Type: ApplicationFiled: January 22, 2009Publication date: July 23, 2009Inventors: Anton J. Steiner, Gary Thomas, Dennis McBride
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Publication number: 20090171467Abstract: A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fibre lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fibre lay; with or without an integral means of firmly anchoring the device to a patient's bone.Type: ApplicationFiled: August 17, 2006Publication date: July 2, 2009Applicant: OXFORD BIOMATERIALS LTD.Inventors: Stephen Mann, David Philip Knight, Nicholas James Vavasour Skaer, Caroline Bertram, Richard O.C. Oreffo, Helmtrud I. Roach, Andrew Michael Collins
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Patent number: 7550007Abstract: Provided are procedures and instruments for preparing and transplanting osteochondral allograft plugs to a host bone to repair an articular cartilage defect. An allograft bone plug having a cartilage plate and cancellous bone tissue attached thereto is removed from a donor bone. The allograft plug is further shaped by removing or cutting away cancellous bone tissue to form a cancellous stalk extending from the cartilage plate. The formed cancellous stalk can have any suitable shape including cylindrical, conical, and rectilinear. At the recipient site of the host bone, a cutout is formed corresponding in shape to the allograft plug. The allograft plug is inserted into the cutout such that the cancellous stalk is retained in the host bone and the cartilage plate aligns with the condyle surface of the host bone. Aspects of the invention may also be applicable to preparing and transplanting osteochondral autograft plugs.Type: GrantFiled: February 23, 2007Date of Patent: June 23, 2009Assignee: Biomet Sports Medicine, LLCInventor: Theodore I. Malinin
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Patent number: 7537617Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of bone pieces formed into at least one load bearing layer.Type: GrantFiled: June 5, 2003Date of Patent: May 26, 2009Assignee: Warsaw Orthopedic, Inc.Inventors: James J. Bindsell, T. Andrew Simonton, Cary R. Reeves, William F. McKay, Eddie F. Ray
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Publication number: 20090125110Abstract: The present invention is a system for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth.Type: ApplicationFiled: October 8, 2008Publication date: May 14, 2009Inventor: Stephen D. Kuslich
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Patent number: 7530982Abstract: A graft formation and delivery instrument comprising an outer barrel, a piston, and an inner pin. The outer barrel has a center aperture. The piston is seated within the center aperture, has a through bore, and is operable to move within the center aperture. The inner pin is seated within the through bore of the piston and operable to move within the through bore. The outer barrel receives multiple graft components that are contacted by at least one of the piston and the inner pin to assemble a composite graft from the graft components. The instrument is operable to direct the composite graft to a desired implant area and deposit the composite graft at the implant area.Type: GrantFiled: October 7, 2004Date of Patent: May 12, 2009Assignee: Biomet Manufacturing Corp.Inventor: David Goshert
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Patent number: 7507254Abstract: The present invention relates to inorganic bone graft materials and a method for preparing the bone graft materials. Particularly, the present invention relates to a method for preparing bone graft materials comprises the following steps: collecting cancellous bones from an animal; removing lipids and organic materials from the cancellous bones using organic solvent, sodium hypochlorite and hydrogen peroxide; and sterilizing the cancellous bones wherefrom the lipids and the organic materials are removed. The bone graft materials prepared by the method of the present invention meet requirements for use in bone grafting, including biocompatibility, sterilization, osteoinductivity and osteoconductivity with free from immunogenecity and toxicity to tissue and are suitable for use in osteogenesis and have morphogenesis.Type: GrantFiled: September 15, 2005Date of Patent: March 24, 2009Assignee: Oscotec, Inc.Inventors: Chang Joon Yim, Se Won Kim, Jung Keun Kim, Jong Yeo Kim, Hyung Gun Kim, Dong Ryung Shin, Yong Mok Yu, Sung Bin Yim, Seon Yle Ko, Sung Churl Lee
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Publication number: 20090069901Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: ApplicationFiled: July 24, 2008Publication date: March 12, 2009Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
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Publication number: 20090062821Abstract: A composite resilient scaffold may be used to grow, repair, and/or regenerate tissue such as articular cartilage. The composite scaffold is porous and at least substantially bioremovable. The composite scaffold includes a support structure coated with a discontinuous coating of separate and discrete particles of a ceramic material such as calcium phosphate. The calcium phosphate material may have a porous reticulated structure.Type: ApplicationFiled: August 31, 2007Publication date: March 5, 2009Applicant: PHILLIPS PLASTICS CORPORATIONInventors: James R. Johnson, Anita Tavakley
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Patent number: 7494950Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.Type: GrantFiled: September 7, 2004Date of Patent: February 24, 2009Assignees: Synthes (U.S.A.), Synthes GmbHInventors: Bryan Monro Armitage, Ira Ison, Mark Fulmer, Sean Kerr, Michael Lehmicke, Patrick Leamy, William Schiffer
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Patent number: 7488348Abstract: The invention is directed toward a cartilage repair assembly comprising a cylindrically shaped allograft structure of subchondral bone with an integral overlying smaller diameter cartilage cap which is treated to remove cellular debris and proteoglycans. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the subchondral bone of the structure engages the side wall of the bone portion of the drilled bore in an interference fit while the cartilage cap is spaced from cartilage portion of the side wall of the drilled bore forming a gap in which a milled cartilage and biocompatible carrier mixture is placed allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: GrantFiled: June 14, 2005Date of Patent: February 10, 2009Assignee: Musculoskeletal Transplant FoundationInventors: Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman, William W. Tomford, Judith I. Yannariello-Brown
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Publication number: 20090024223Abstract: The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation.Type: ApplicationFiled: July 16, 2007Publication date: January 22, 2009Inventors: Silvia S. Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, JR.
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Publication number: 20090024224Abstract: The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue.Type: ApplicationFiled: July 16, 2007Publication date: January 22, 2009Inventors: Silvia S. Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, JR.
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Publication number: 20090018667Abstract: The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium suphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprises a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and/or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery.Type: ApplicationFiled: July 23, 2008Publication date: January 15, 2009Inventors: Lars Lidgren, Malin Nilsson
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Publication number: 20090012625Abstract: A porous biomaterial-filler composite comprising a biomaterial, such as collagen, interspersed with a calcium phosphate-type filler material. The porosity of the composite is similar to that of natural bone and can feature a pore size ranging from a few nanometres to greater than 100 microns. Scaffolds prepared from the biomaterial-filler composite are suitable for resorbable bone substitute materials.Type: ApplicationFiled: September 14, 2004Publication date: January 8, 2009Inventors: Jackie Y. Ying, Shona Pek, Shujun Gao, Mohamed Shariff Arshad, Pei Lin Mao
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Publication number: 20090005882Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.Type: ApplicationFiled: September 8, 2008Publication date: January 1, 2009Inventors: Michael L. Boyer, III, David C. Paul, Christopher M. Angelucci
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Publication number: 20090005881Abstract: The present invention aims at providing a biomaterial composite not having risks of pathogen infection and unfavorable side effects such as rejection response. According to the invention, there is provided a biomaterial composite, which comprises a polypeptide and a calcium phosphate compound, said peptide comprising the units of Formulas (I) to (III): [—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a??(I) [—(OC—(CH2)m—CO)p-(z)r-]b??(II) [—HN—R—NH—]c??(III) wherein m, p, q, Y, n, Z, r, R, a, b and c are as defined in the specification. The composite of the invention is particularly suitable for an artificial bone due to its high biocompatibility, high endurance and mechanical strength. Further, the invention can provide a process of the composite according to the invention can for preparation of the composite having excellent mechanical characteristics by a simple procedure.Type: ApplicationFiled: March 14, 2006Publication date: January 1, 2009Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OFInventors: Masanobu Kamitakahara, Masao Tanihara, Chikara Ohtsuki, Shinichi Ogata
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Patent number: 7462200Abstract: The present invention provides a method for tissue grafting. The method includes obtaining tissue harvested from an individual, obtaining allograft material, placing the allograft material in a chamber, adding the tissue to the allograft material in the chamber with force to create graft material, and implanting the graft material in the individual.Type: GrantFiled: November 23, 2005Date of Patent: December 9, 2008Assignee: Marctec, LLCInventor: Peter M. Bonutti
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Patent number: 7459018Abstract: A calcium phosphate composition comprising at least one calcium phosphate mineral, at least one reaction retarding agent, at least one biding agent, and at least one sodium phosphate compound.Type: GrantFiled: December 20, 2005Date of Patent: December 2, 2008Assignee: Howmedica Leibinger Inc.Inventors: Gerard M. Insley, Adrian Sun Wai, Donal O'Mahony, Paul Higham
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Publication number: 20080294270Abstract: A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber.Type: ApplicationFiled: May 24, 2007Publication date: November 27, 2008Applicant: ZIMMER ORTHOBIOLOGICS, INC.Inventors: Jian Q. Yao, Hai-Qing Xian, Jizong Gao, Rodney Bristol, Victor Zaporojan, Hali Wang, Hui Liu
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Publication number: 20080281432Abstract: An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell-containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device.Type: ApplicationFiled: October 23, 2006Publication date: November 13, 2008Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Birgit Schaefer, Lothar Schloesser
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Publication number: 20080262632Abstract: A method for obtaining of biomaterials for osteoplasty and tissue engineering cleans a bone of natural origin, which is sawn to plates with a thickness of 0.2 to 2.0 cm, washed twice in 0.1 M phosphate buffer at 65° C., pH 5.8-6.0, calculated as two volumetric parts of the buffer solution per one part of bone, digested in a solution of activated 0.1-0.4% papain at 65° C. for 24 hours. The plates are washed with 5 volumes of water at the temperature 40-80° C., treated with 0.4 N alkali solution at room temperature for 10-24 hours, washed with flowing water, dried, defatted in ethanol/chloroform mixtures in proportion of 1:2 and then in proportion of 2:1, decalcified in 0.4-1 N hydrochloric acid, treated with 1.5-3% hydrogen peroxide for 4 hours, washed with treated water, then washed with ethanol, dried at room temperature, packed and sterilized.Type: ApplicationFiled: October 27, 2005Publication date: October 23, 2008Inventor: Andrey Fedorovich Panasyuk
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Publication number: 20080262633Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.Type: ApplicationFiled: April 28, 2008Publication date: October 23, 2008Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
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Publication number: 20080255676Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.Type: ApplicationFiled: January 24, 2007Publication date: October 16, 2008Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
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Publication number: 20080249632Abstract: A method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.Type: ApplicationFiled: February 26, 2007Publication date: October 9, 2008Applicant: Biomet Sports Medicine, Inc.Inventors: Kevin T. Stone, Karen Troxel
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Patent number: 7427293Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.Type: GrantFiled: March 28, 2006Date of Patent: September 23, 2008Assignee: SDGI Holdings, Inc.Inventors: Jeffrey H Nycz, Keith M Kinnane, Susan J Drapeau, Daniel A Shimko, Jeetendra S Bharadwaj
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Publication number: 20080188946Abstract: Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo.Type: ApplicationFiled: January 23, 2008Publication date: August 7, 2008Applicant: Etex CorporationInventors: Aron D. Rosenberg, Laurent D. Gilles de Pelichy, Daniel Egan, Aliassghar N. Tofighi, Dosuk D. Lee, Youngmi M. Lee
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Patent number: 7393493Abstract: The present invention relates to a novel composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture.Type: GrantFiled: February 26, 2004Date of Patent: July 1, 2008Assignee: A Enterprises, Inc.Inventors: Arthur Ashman, V. Prasad Shastri
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Publication number: 20080125863Abstract: The invention herein generally refers to an in situ cartilage repair implant. The implant promotes cartilage repair by providing a sealed barrier that prevents the flow of synovial fluid and inflammatory cytokines into a surgically prepared hole that accommodates the implant. Optionally, additives are associated with the implant to promote cartilage repair.Type: ApplicationFiled: November 28, 2006Publication date: May 29, 2008Inventor: William F. McKay
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Patent number: 7371409Abstract: A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.Type: GrantFiled: September 6, 2001Date of Patent: May 13, 2008Assignee: Wright Medical Technology, Inc.Inventors: Donald W. Petersen, Barbara E. Blum
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Patent number: 7371408Abstract: A bone graft substitute composition comprising calcium sulfate; a mixing solution selected from the group consisting of sterile water, sodium chloride, phosphate buffered saline, potassium chloride, and sodium sulfate; and a plasticizing substance selected from the group consisting of carboxymethylcellulose, polyvinyl alcohol, methycellulose, and hydroxypropyl methylcellulose.Type: GrantFiled: June 7, 1999Date of Patent: May 13, 2008Assignee: Wright Medical Technology, Inc.Inventors: Donald W. Petersen, Warren O. Haggard, Donald A. Randolph, Cary P. Hagan
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Patent number: 7371410Abstract: A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.Type: GrantFiled: January 30, 2002Date of Patent: May 13, 2008Assignee: Wright Medical Technology, Inc.Inventor: Donald W. Petersen
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Patent number: 7368065Abstract: Compositions and methods are provided for preparing a metal substrate having a uniform textured surface with a plurality of indentations with a diameter in the nanometer and micrometer range. The textured surface is produced by exposing the substrate to an etching fluid comprising a hydrohalic acid and a mixture of a hydrohalic acid and an oxyacid, a chloride containing compound, and an oxidant. The etching solution can be used at ambient temperature. This textured surface enhances adherence of coatings or cells onto the textured surface, improves the retention of proteins on the surface, and encourages bone in-growth.Type: GrantFiled: June 23, 2005Date of Patent: May 6, 2008Assignee: DePuy Products, Inc.Inventors: Xiaofan Yang, Panjian Li, Todd Smith
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Patent number: 7361195Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.Type: GrantFiled: July 15, 2002Date of Patent: April 22, 2008Assignee: DePuy Products, Inc.Inventors: Herbert E. Schwartz, Prasanna Malaviya, Mark J. Pelo, Pamela L. Plouhar
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Patent number: 7351262Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of pieces of bone and a flexible mechanism including one or more flexible, elongate, biocompatible connectors interconnecting the pieces of bone.Type: GrantFiled: June 5, 2003Date of Patent: April 1, 2008Assignee: Warsaw Orthopedic, Inc.Inventors: James J. Bindseil, T. Andrew Simonton, Cary R. Reeves, William F. McKay, Eddie F. Ray
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Publication number: 20080058953Abstract: An osteoimplant includes at least partially demineralized cancellous bone as a substrate, which is impregnated with demineralized cortical bone matrix (DBM). The implant may include a binding agent to adhere the DBM to the cancellous bone substrate, and may also include a soft tissue barrier that covers a portion of the external surface of the implant. The cancellous bone substrate may be selectively demineralized, so as to provide regions with greater malleability, and other regions with greater structural properties.Type: ApplicationFiled: August 31, 2006Publication date: March 6, 2008Inventor: Nelson L. Scarborough
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Publication number: 20080033572Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.Type: ApplicationFiled: August 3, 2006Publication date: February 7, 2008Applicant: EBI L.P.Inventors: Paul D'Antonio, Joshua Simon, Benjamin T. Cripps
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Publication number: 20070283849Abstract: A self-foaming bone cement is described herein. In one variation, the bone cements include a self setting calcium phosphate cement formulation which when cured, forms macroscopic pores of varying sizes and densities with sufficient surface area to provide substantial regions for bone turnover.Type: ApplicationFiled: June 8, 2006Publication date: December 13, 2007Inventors: Avram Allan Edidin, Robert Wenz, Jorg Meyer
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Publication number: 20070276506Abstract: A shelf-stable, demineralized, and freeze-dried osteochondral plug comprising cartilage, subchondral bone, and the underlying cancellous bone is provided. Methods of preparing the demineralized osteochondral plug and methods of repairing a defect site are also provided.Type: ApplicationFiled: May 25, 2006Publication date: November 29, 2007Applicant: Biomet Manufacturing Corp.Inventor: Karen Troxel
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Patent number: 7291179Abstract: Bone graft substitute compositions and methods of making the compositions are disclosed. In some embodiments, a method of making a composition includes contacting a mixing solution with a first mixture having calcium sulfate hemihydrate and a plasticizing material to form a second mixture; waiting a predetermined period of time after forming said second mixture; and then contacting demineralized bone with the second mixture to form the composition. A composition can be formed from a kit including a first mixture having calcium sulfate hemihydrate and a plasticizing substance, a second mixture having demineralized bone, and a mixing solution. The first and second mixtures and the mixing solution are unblended.Type: GrantFiled: May 30, 2003Date of Patent: November 6, 2007Assignee: Wright Medical Technology, Inc.Inventors: Leasa C. Miller, Kelly Coupe Richelsoph, Jon P. Moseley