Including Natural Bone Tissue Patents (Class 623/23.63)
  • Publication number: 20090024223
    Abstract: The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation.
    Type: Application
    Filed: July 16, 2007
    Publication date: January 22, 2009
    Inventors: Silvia S. Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, JR.
  • Publication number: 20090024224
    Abstract: The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue.
    Type: Application
    Filed: July 16, 2007
    Publication date: January 22, 2009
    Inventors: Silvia S. Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, JR.
  • Publication number: 20090018667
    Abstract: The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium suphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprises a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and/or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery.
    Type: Application
    Filed: July 23, 2008
    Publication date: January 15, 2009
    Inventors: Lars Lidgren, Malin Nilsson
  • Publication number: 20090012625
    Abstract: A porous biomaterial-filler composite comprising a biomaterial, such as collagen, interspersed with a calcium phosphate-type filler material. The porosity of the composite is similar to that of natural bone and can feature a pore size ranging from a few nanometres to greater than 100 microns. Scaffolds prepared from the biomaterial-filler composite are suitable for resorbable bone substitute materials.
    Type: Application
    Filed: September 14, 2004
    Publication date: January 8, 2009
    Inventors: Jackie Y. Ying, Shona Pek, Shujun Gao, Mohamed Shariff Arshad, Pei Lin Mao
  • Publication number: 20090005881
    Abstract: The present invention aims at providing a biomaterial composite not having risks of pathogen infection and unfavorable side effects such as rejection response. According to the invention, there is provided a biomaterial composite, which comprises a polypeptide and a calcium phosphate compound, said peptide comprising the units of Formulas (I) to (III): [—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a??(I) [—(OC—(CH2)m—CO)p-(z)r-]b??(II) [—HN—R—NH—]c??(III) wherein m, p, q, Y, n, Z, r, R, a, b and c are as defined in the specification. The composite of the invention is particularly suitable for an artificial bone due to its high biocompatibility, high endurance and mechanical strength. Further, the invention can provide a process of the composite according to the invention can for preparation of the composite having excellent mechanical characteristics by a simple procedure.
    Type: Application
    Filed: March 14, 2006
    Publication date: January 1, 2009
    Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF
    Inventors: Masanobu Kamitakahara, Masao Tanihara, Chikara Ohtsuki, Shinichi Ogata
  • Publication number: 20090005882
    Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
    Type: Application
    Filed: September 8, 2008
    Publication date: January 1, 2009
    Inventors: Michael L. Boyer, III, David C. Paul, Christopher M. Angelucci
  • Patent number: 7462200
    Abstract: The present invention provides a method for tissue grafting. The method includes obtaining tissue harvested from an individual, obtaining allograft material, placing the allograft material in a chamber, adding the tissue to the allograft material in the chamber with force to create graft material, and implanting the graft material in the individual.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: December 9, 2008
    Assignee: Marctec, LLC
    Inventor: Peter M. Bonutti
  • Patent number: 7459018
    Abstract: A calcium phosphate composition comprising at least one calcium phosphate mineral, at least one reaction retarding agent, at least one biding agent, and at least one sodium phosphate compound.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: December 2, 2008
    Assignee: Howmedica Leibinger Inc.
    Inventors: Gerard M. Insley, Adrian Sun Wai, Donal O'Mahony, Paul Higham
  • Publication number: 20080294270
    Abstract: A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber.
    Type: Application
    Filed: May 24, 2007
    Publication date: November 27, 2008
    Applicant: ZIMMER ORTHOBIOLOGICS, INC.
    Inventors: Jian Q. Yao, Hai-Qing Xian, Jizong Gao, Rodney Bristol, Victor Zaporojan, Hali Wang, Hui Liu
  • Publication number: 20080281432
    Abstract: An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell-containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device.
    Type: Application
    Filed: October 23, 2006
    Publication date: November 13, 2008
    Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIE
    Inventors: Birgit Schaefer, Lothar Schloesser
  • Publication number: 20080262632
    Abstract: A method for obtaining of biomaterials for osteoplasty and tissue engineering cleans a bone of natural origin, which is sawn to plates with a thickness of 0.2 to 2.0 cm, washed twice in 0.1 M phosphate buffer at 65° C., pH 5.8-6.0, calculated as two volumetric parts of the buffer solution per one part of bone, digested in a solution of activated 0.1-0.4% papain at 65° C. for 24 hours. The plates are washed with 5 volumes of water at the temperature 40-80° C., treated with 0.4 N alkali solution at room temperature for 10-24 hours, washed with flowing water, dried, defatted in ethanol/chloroform mixtures in proportion of 1:2 and then in proportion of 2:1, decalcified in 0.4-1 N hydrochloric acid, treated with 1.5-3% hydrogen peroxide for 4 hours, washed with treated water, then washed with ethanol, dried at room temperature, packed and sterilized.
    Type: Application
    Filed: October 27, 2005
    Publication date: October 23, 2008
    Inventor: Andrey Fedorovich Panasyuk
  • Publication number: 20080262633
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
    Type: Application
    Filed: April 28, 2008
    Publication date: October 23, 2008
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
  • Publication number: 20080255676
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
    Type: Application
    Filed: January 24, 2007
    Publication date: October 16, 2008
    Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
  • Publication number: 20080249632
    Abstract: A method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.
    Type: Application
    Filed: February 26, 2007
    Publication date: October 9, 2008
    Applicant: Biomet Sports Medicine, Inc.
    Inventors: Kevin T. Stone, Karen Troxel
  • Patent number: 7427293
    Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: September 23, 2008
    Assignee: SDGI Holdings, Inc.
    Inventors: Jeffrey H Nycz, Keith M Kinnane, Susan J Drapeau, Daniel A Shimko, Jeetendra S Bharadwaj
  • Publication number: 20080188946
    Abstract: Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo.
    Type: Application
    Filed: January 23, 2008
    Publication date: August 7, 2008
    Applicant: Etex Corporation
    Inventors: Aron D. Rosenberg, Laurent D. Gilles de Pelichy, Daniel Egan, Aliassghar N. Tofighi, Dosuk D. Lee, Youngmi M. Lee
  • Patent number: 7393493
    Abstract: The present invention relates to a novel composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: July 1, 2008
    Assignee: A Enterprises, Inc.
    Inventors: Arthur Ashman, V. Prasad Shastri
  • Publication number: 20080125863
    Abstract: The invention herein generally refers to an in situ cartilage repair implant. The implant promotes cartilage repair by providing a sealed barrier that prevents the flow of synovial fluid and inflammatory cytokines into a surgically prepared hole that accommodates the implant. Optionally, additives are associated with the implant to promote cartilage repair.
    Type: Application
    Filed: November 28, 2006
    Publication date: May 29, 2008
    Inventor: William F. McKay
  • Patent number: 7371409
    Abstract: A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: May 13, 2008
    Assignee: Wright Medical Technology, Inc.
    Inventors: Donald W. Petersen, Barbara E. Blum
  • Patent number: 7371410
    Abstract: A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: May 13, 2008
    Assignee: Wright Medical Technology, Inc.
    Inventor: Donald W. Petersen
  • Patent number: 7371408
    Abstract: A bone graft substitute composition comprising calcium sulfate; a mixing solution selected from the group consisting of sterile water, sodium chloride, phosphate buffered saline, potassium chloride, and sodium sulfate; and a plasticizing substance selected from the group consisting of carboxymethylcellulose, polyvinyl alcohol, methycellulose, and hydroxypropyl methylcellulose.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: May 13, 2008
    Assignee: Wright Medical Technology, Inc.
    Inventors: Donald W. Petersen, Warren O. Haggard, Donald A. Randolph, Cary P. Hagan
  • Patent number: 7368065
    Abstract: Compositions and methods are provided for preparing a metal substrate having a uniform textured surface with a plurality of indentations with a diameter in the nanometer and micrometer range. The textured surface is produced by exposing the substrate to an etching fluid comprising a hydrohalic acid and a mixture of a hydrohalic acid and an oxyacid, a chloride containing compound, and an oxidant. The etching solution can be used at ambient temperature. This textured surface enhances adherence of coatings or cells onto the textured surface, improves the retention of proteins on the surface, and encourages bone in-growth.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: May 6, 2008
    Assignee: DePuy Products, Inc.
    Inventors: Xiaofan Yang, Panjian Li, Todd Smith
  • Patent number: 7361195
    Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: April 22, 2008
    Assignee: DePuy Products, Inc.
    Inventors: Herbert E. Schwartz, Prasanna Malaviya, Mark J. Pelo, Pamela L. Plouhar
  • Patent number: 7351262
    Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of pieces of bone and a flexible mechanism including one or more flexible, elongate, biocompatible connectors interconnecting the pieces of bone.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: April 1, 2008
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: James J. Bindseil, T. Andrew Simonton, Cary R. Reeves, William F. McKay, Eddie F. Ray
  • Publication number: 20080058953
    Abstract: An osteoimplant includes at least partially demineralized cancellous bone as a substrate, which is impregnated with demineralized cortical bone matrix (DBM). The implant may include a binding agent to adhere the DBM to the cancellous bone substrate, and may also include a soft tissue barrier that covers a portion of the external surface of the implant. The cancellous bone substrate may be selectively demineralized, so as to provide regions with greater malleability, and other regions with greater structural properties.
    Type: Application
    Filed: August 31, 2006
    Publication date: March 6, 2008
    Inventor: Nelson L. Scarborough
  • Publication number: 20080033572
    Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.
    Type: Application
    Filed: August 3, 2006
    Publication date: February 7, 2008
    Applicant: EBI L.P.
    Inventors: Paul D'Antonio, Joshua Simon, Benjamin T. Cripps
  • Publication number: 20070283849
    Abstract: A self-foaming bone cement is described herein. In one variation, the bone cements include a self setting calcium phosphate cement formulation which when cured, forms macroscopic pores of varying sizes and densities with sufficient surface area to provide substantial regions for bone turnover.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 13, 2007
    Inventors: Avram Allan Edidin, Robert Wenz, Jorg Meyer
  • Publication number: 20070276506
    Abstract: A shelf-stable, demineralized, and freeze-dried osteochondral plug comprising cartilage, subchondral bone, and the underlying cancellous bone is provided. Methods of preparing the demineralized osteochondral plug and methods of repairing a defect site are also provided.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 29, 2007
    Applicant: Biomet Manufacturing Corp.
    Inventor: Karen Troxel
  • Patent number: 7291179
    Abstract: Bone graft substitute compositions and methods of making the compositions are disclosed. In some embodiments, a method of making a composition includes contacting a mixing solution with a first mixture having calcium sulfate hemihydrate and a plasticizing material to form a second mixture; waiting a predetermined period of time after forming said second mixture; and then contacting demineralized bone with the second mixture to form the composition. A composition can be formed from a kit including a first mixture having calcium sulfate hemihydrate and a plasticizing substance, a second mixture having demineralized bone, and a mixing solution. The first and second mixtures and the mixing solution are unblended.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: November 6, 2007
    Assignee: Wright Medical Technology, Inc.
    Inventors: Leasa C. Miller, Kelly Coupe Richelsoph, Jon P. Moseley
  • Patent number: 7162850
    Abstract: A system and method of packaging a bone allograft for use in a future medical procedure in which the bone allograft is stored in a saturated saline solution in an airtight container. The saline solution keeps the allograft hydrated and may be saturated with a combination of calcium, phosphate, or magnesium to inhibit mineral leaching out of the allograft during storage. The container may be deformable to conform to the shape of the allograft material as the container is “shrink-fitted” to the allograft. Optionally, the bone allograft may also be freeze-dried prior to placement in the container.
    Type: Grant
    Filed: May 25, 2004
    Date of Patent: January 16, 2007
    Assignee: NuVasive, Inc.
    Inventors: James F. Marino, Bryan Cornwall
  • Patent number: 7141072
    Abstract: A method of promoting regeneration of surface cartilage of a joint includes the steps of covering the area to be treated with a patch which includes a sheet of collagen membrane material. The collagen membrane material has at least one barrier layer to prevent passage of cells therethrough. The collagen membrane further includes a matrix layer predominantly of collagen II having an open sponge-like texture. The patch is fixed over the area to be treated, and the area is allowed to regenerate cartilage.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: November 28, 2006
    Assignee: Ed. Geistlich Soehne AG fuer Chemische Industrie
    Inventors: Peter Geistlich, Lothar Schloesser
  • Patent number: 7115146
    Abstract: The present invention relates to an implant comprising two or more bone fragments that are combined to form a single unit. Cancellous bone or cortical bone is removed from a source and fashioned into bone components with desirable shapes and sizes. The bone components may be integrated to form implants for implantation in the body. Bone stock may be formed by combining sections of various bones of the body, and the bone stock may be further fashioned for use as implants with particular geometries.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: October 3, 2006
    Inventors: Michael L. Boyer, II, David C. Paul, Thomas B. Higgins
  • Patent number: 7087082
    Abstract: A bone fusion implant for repair or replacement of bone includes a hollow body formed from at least two bone fragments which are configured and dimensioned for mutual engagement and which are coupled together. The hollow body may be formed of autograft, allograft, or xenograft bone tissue, and may include a core formed of at least one of bone material and bone inducing substances, with the core being disposed in the hollow body.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: August 8, 2006
    Assignee: Synthes (USA)
    Inventors: David C. Paul, Hansjuerg W. Emch, Beat Schenk, Michael L. Boyer, II, Thomas B. Higgins
  • Patent number: 7087087
    Abstract: The present invention relates to an implant comprising two or more bone fragments that are combined to form a single unit. Cancellous bone or cortical bone is removed from a source and fashioned into bone components with desirable shapes and sizes. The bone components may be integrated to form implants for implantation in the body. Bone stock may be formed by combining sections of various bones of the body, and the bone stock may be further fashioned for use as implants with particular geometries.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: August 8, 2006
    Inventors: Michael L. Boyer, II, David C. Paul, Thomas B. Higgins
  • Patent number: 7056577
    Abstract: A body, such as a grain, for providing ingrowth and growth of bone tissue and/or connective tissue. The body consists of a plastic or non-essentially elastic biocompatible material, preferably metal or metal alloy. It is also porous, having the following porosity characteristics: (a) the porosity is continuous and (b) the opening of cavities/indentations/pockets and the ducts connecting them has the width of >about 50 ?m for bone tissue and >about 10 ?m for connective tissue. In a method of making such a body, the body has been produced by blowing gas into a melt of metal. An advantageous use of bodies according to the invention is enclosing thereof in a casing, formed with openings, for making an implant, such as a spinal implant.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: June 6, 2006
    Assignee: Tigran Technologies AB
    Inventors: Ingrid Bruce, Lars Bruce
  • Patent number: 7001551
    Abstract: A method of forming a bone composite, comprising: providing bone tissue; grinding said bone tissue to form ground tissue; molding the ground bone tissue into a bone composite; applying a binder to the bone composite; applying a vacuum to the mold, and optionally milling or refining the bone composite to the desired shape. Additionally, bone tissue composites made therefrom are included. The composites may be, for example, a bone pin, screw, or prosthesis.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: February 21, 2006
    Assignee: Allograft Research Technologies, Inc.
    Inventor: Thomas L. Meredith
  • Patent number: 6989029
    Abstract: The present invention relates to an implantable cage for holding tissue graft material. The cage includes a chamber configured and dimensioned to receive the tissue graft material and at least one side wall defining the chamber. In one embodiment, the cage is made of a biodegradable material. In another embodiment, the cage is made of a material that includes a bone-growth enhancer.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: January 24, 2006
    Assignee: Bonutti IP, LLC
    Inventor: Peter M. Bonutti
  • Patent number: 6972041
    Abstract: The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft for implantation into humans. The invention further provides a method for preparing a bone xenograft by removing at least a portion of a bone from a non-human animal to provide a xenograft (X); washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; and treating the xenograft with a glycosidase to remove surface carbohydrate moieties. The invention also provides an article of manufacture produced by the above identified method of invention. The invention further provides a bone xenograft for implantation into a human including a portion (10) of a bone from a nonhuman animal, wherein the portion has substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. Each xenograft of the invention has substantially the same mechanical properties as a corresponding native bone.
    Type: Grant
    Filed: March 15, 1999
    Date of Patent: December 6, 2005
    Assignee: CrossCart, Inc.
    Inventor: Kevin R. Stone
  • Patent number: 6913621
    Abstract: Implantable devices useful for creating bony fusion particularly in intervertebral spinal fusion. The device is formed of bone and has an at least partially demineralized portion between two rigid bone portions creating an area of flexibility. In one application, the area of flexibility may be used to move the device between a reduced size insertion configuration and an expanded implanted configuration. In another use, the area of flexibility may be useful to dampen shock applied to the implant. A method is also disclosed for making the implants and inserting the implants into an intervertebral disc space to promote interbody fusion.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: July 5, 2005
    Assignee: SDGI Holdings, Inc.
    Inventors: Lawrence M. Boyd, John A. Pafford
  • Patent number: 6911212
    Abstract: The invention is directed toward a malleable bone putty and a flowable pastel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of partially demineralized lyophilized allograft bone material having a residual calcium content ranging from 4 to 8% dry weight. The bone powder has a particle size ranging from about 100 to about 800 microns and is mixed in a high molecular weight hydrogel carrier containing a sodium phosphate saline buffer, the hydrogel component of the carrier ranging from about 1.00 to 50% of the composition and having a molecular weight of about at least 700,000 Daltons. The composition has a pH between 6.8-7.4 contains about 25% to about 35% bone powder and can be additionally provided with BMP's.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: June 28, 2005
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Arthur A. Gertzman, Moon H. Sunwoo
  • Patent number: 6905517
    Abstract: The present invention relates to a tissue grafting material that includes a first tissue element harvested from an individual, a carrier, and a therapeutic substance contained in the carrier. The carrier and therapeutic substance are incorporated into the first tissue element and the first tissue element, carrier, and therapeutic substance form a unitary implant.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: June 14, 2005
    Assignee: Bonutti IP, LLP
    Inventor: Peter M. Bonutti
  • Patent number: 6863694
    Abstract: An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32% and a method of making an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: March 8, 2005
    Assignee: Osteotech, Inc.
    Inventors: Todd M. Boyce, David Kaes, Nelson L. Scarborough
  • Patent number: 6860904
    Abstract: A method of tissue grafting. Tissue elements are obtained from at least one human body and are enclosed within a retaining structure. The tissue elements with the retaining structure are shaped to form a grafting material having a predetermined configuration. The grafting material is then implanted into a patient.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: March 1, 2005
    Assignee: Bonutti 2003 Trust-A
    Inventor: Peter M. Bonutti
  • Patent number: 6855169
    Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: February 15, 2005
    Assignee: Synthes (USA)
    Inventors: Michael L. Boyer, II, David C. Paul, Christopher M. Angelucci
  • Patent number: 6855167
    Abstract: A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form the offsets and different configurations for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: February 15, 2005
    Assignee: Osteotech, Inc.
    Inventors: Lawrence A. Shimp, John M. Winterbottom, David R. Kaes, Todd M. Boyce, Erik O. Martz
  • Patent number: 6843807
    Abstract: An osteoimplant comprises a solid aggregate of bone derived elements, adjacent bone-derived elements being bonded to each other through chemical linkages between their adjacent surface-exposed collagen. Various other components can be incorporated into the bone implant material such as bone-growth inducing substances.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: January 18, 2005
    Assignee: Osteotech Inc.
    Inventors: Todd M. Boyce, Albert Manrique
  • Publication number: 20040249448
    Abstract: The invention concerns a device and methods for providing implants, cells or tissues, for example for grafts or in vitro research cultures, of tissue engineering or cellular therapy. The invention is particularly adapted to produce, in sufficient amount, specific cell populations with high proliferation and/or differentiation potential, adapted for use in tissue engineering, in repair surgery or therapy, particularly for humans. The invention also concerns a method for preparing such a device and its uses, in particular for treating tissue loss, and kits, tranplants, tissues or biological preparations.
    Type: Application
    Filed: June 9, 2004
    Publication date: December 9, 2004
    Inventor: Philippe Gault
  • Publication number: 20040243242
    Abstract: An implant which is particularly suitable for the repair and/or replacement of a skeletal joint, e.g., a vertebral joint, includes a unit of monolithic bone possessing at least one demineralized region exhibiting properties of flexibility and resilience, the demineralized region having diminished or insignificant capacity for promoting new bone growth.
    Type: Application
    Filed: May 25, 2004
    Publication date: December 2, 2004
    Inventors: Daryl R. Sybert, Lawrence A. Shimp
  • Patent number: 6808585
    Abstract: An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32% and a method of making an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: October 26, 2004
    Assignee: Osteotech, Inc.
    Inventors: Todd M. Boyce, David Kaes, Nelson L. Scarborough
  • Patent number: RE38614
    Abstract: An allogenic intervertebral implant for fusing vertebrae is disclosed. The implant is a piece of allogenic bone conforming in size and shape with a portion of an end plate of a vertebra. The implant has a wedge-shaped profile to restore disc height and the natural curvature of the spine. The top and bottom surfaces of the implant have a plurality of teeth to resist expulsion and provide initial stability. The implant according to the present invention provides initial stability need for fusion without stress shielding.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: October 5, 2004
    Assignee: Synthes (U.S.A.)
    Inventors: David C. Paul, Hansjuerg W. Emch, Beat Schenk