Abstract: The present invention quickly resolves troubles in an analyzer and performs effective external quality control management. An analyzer (2) and a control device (1) are connected by a network (3). Error data and sample data taken from an assay of a quality control substance are transmitted from the control device (1) to the analyzer (2). The analyzer (2) is made to be remotely operable from the control device (1) and when problems arise, repair from the control device (1) is possible. The control device (1) tallies sample data and provides the tally results to a Web page. The analyzer (2) accesses the Web page using a WWW browser, and it can perform external quality control in real time.

Abstract: A method of optimizing a chemical reaction in a plate-type open reactor, the method consisting in: establishing a dynamic model of the reactor for a given reaction on the basis of a model of the reactor and its heat exchanges; applying an integration software tool to the dynamic model in order to solve the above-mentioned equations; determining and optimizing a set of dimension and/or operation parameters of the reactor on the basis of evaluating targets to be achieved, constraints to be complied with, and variable data for the reactor and/or the reaction; building a plate reactor of the said type accordingly to the set of optimized parameters; and doing measurements of physical parameters during the execution of said reaction in the built reactor, for validating its operation.

Abstract: A method is provided of calculating the structure of an inhomogeneous sample in which an electron beam is used to cause excitation of x-rays from the sample under known conditions of beam energy and geometry with respect to the sample. Notably the beam current is unknown. Measured x-ray intensity data for the sample corresponding to one or more sets of beam conditions and beam currents are firstly obtained, together with comparative x-ray intensity data for samples having known structures. A beam current factor for each beam condition is estimated and effective x-ray intensity data for each of the sets of conditions are then calculated using the measured and comparative x-ray intensity data and the beam current factor. The structure of the sample is then calculated for each of the sets of conditions using the effective x-ray intensity data. Predicting x-ray intensity data are produced corresponding to the calculated structure and compared with the effective x-ray intensity data.

Abstract: Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass spectrometry data that include providing a reference set of mass spectrometry data obtained from a first external standard sample having one or more isotopic standards, wherein the reference set of mass spectrometry data comprises one or more m/z intensity ratios. Methods described herein are useful for reducing errors based on instrument response and ionization efficiencies and improve reproducibility of data from instrument to instrument and from day to day.

Abstract: A system and method to automatically implement quality control of a clinical diagnostic process are disclosed. Upon generation of an internal error flag, a confirmation rule automatically checks a questionable patient statistic alert by testing a quality control specimen, applying event-related quality control rules to the results of that test, and provides an alert to the operator only upon a confirmed patient signal. The automatic quality control process thus eliminates the uncertainty of operator reaction to an alert signal and implements the quality control run automatically, without operator intervention.

Abstract: A method is disclosed. The method includes determining an amount of energy needed to change a first sample temperature of a first sample to a target temperature when a temperature changing element that changes the sample temperature is at the target temperature. Data associated with the amount of energy needed to change the sample temperature of the sample to the target temperature is then stored. The stored data may thereafter be used to quickly change a second sample temperature of a second sample to the target temperature, without having the second sample temperature exceed the target temperature.

Abstract: A method for discriminating particle groups comprises generating, by a particle analyzer, a particle characteristic distribution histogram in which the abscissa indicates respective channels for representing the characteristics of the particles, and the ordinate indicates the particle count; setting a valid area selection height in the particle characteristics distribution histogram; and generating an equivalent negative histogram based on the set height and the particle characteristic distribution histogram.

Abstract: Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.

Abstract: The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans.

Abstract: A spectral image processing system and method of performing robust unmixing on measurement noise. Based on an observed spectral image acquired from a specimen and emission spectral data of each of plural materials contained in the specimen, a contribution of each of the plural materials to the observed spectral image is unmixed by a process, including an evaluating step of evaluating reliability of each component of the observed spectral image based on a predicted spectral image of the observed spectral image, and a reflecting step of reflecting a result of the evaluation in a content of the unmixing.

Abstract: The present invention provides methods, devices, and systems for analyzing defects in an object such as a semiconductor wafer. In one embodiment, it provides a method of characterizing defects in semiconductor wafers during fabrication in a semiconductor fabrication facility. This method comprises the following actions. The semiconductor wafers are inspected to locate defects. Locations corresponding to the located defects are then stored in a defect file. A dual charged-particle beam system is automatically navigated to the vicinity defect location using information from the defect file. The defect is automatically identified and a charged particle beam image of the defect is then obtained. The charged particle beam image is then analyzed to characterize the defect. A recipe is then determined for further analysis of the defect. The recipe is then automatically executed to cut a portion of the defect using a charged particle beam.

Abstract: Computing units are determined for performing molecular docking calculations in parallel with the number of computing units and the width of the data paths allocated by relative complexity of operations. Data can be expected to arrive at downstream computing units as it is needed, leading to higher utilization of computing units. Computing units are hardware components that are specific to a calculation performed. For molecular docking calculations, functions of molecular subsets or of combinations of molecular subsets are calculated. Determinations include fit between molecular subsets, affinity or energy of “fit” between molecular subsets, etc. Affinity might include inter-atomic energy, bond energy, energy of atoms immersed in a field, etc. The calculations could be used to simulate and/or estimate likelihoods of molecular interactions.

Abstract: An embodiment of a medical imaging system is proposed. The system includes means for providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part, and means for associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time; the system further includes means for generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and means for displaying the sequence of computed images.

Abstract: A method and system for estimating an air quality condition based on vehicle data received from surrounding vehicles is disclosed. The method includes a step of determining a dynamic traffic pattern from the received vehicle data to determine a level of congestion. The method also includes a step of estimating the air quality condition based on the dynamic traffic pattern. The method and system further includes adjusting one or more settings of a cabin air control system based on the estimated air quality condition.

Abstract: The present disclosure relates to methods for separating or isolating a peptide using reverse phase chromatography. The disclosure also relates to methods for calculating or determining the slope S of a peptide, wherein S is defined according to the Linear-Solvent-Strength equation log k=log k0?S*?. Also provided are a set of peptides with known S values suitable for use in the described methods.

Abstract: A method and apparatus for detecting a particular chemical in a sample, includes placing the sample in contact with a semiconductive material provided on a flow cell. An electrical characteristic of the semiconductive material is detected by an interdigitated electrode, and a first signal indicative thereof of output. An optical characteristic of the semiconductive material is detected by a photodetector and a second signal indicative thereof is output. Based on the first and second signals, it is determined by a processor as to whether or not the particular chemical is present in the sample.

Abstract: An Inductive Probe/Conductive Probe Emulator is designed to replace conductive probes at a much lower cost than existing inductive probe systems. The conductivity probe simulator is usable with any industrial controller that uses a standard two wire conductivity probe interface. A continuously variable semiconductor resistive element is employed to match the conductivity of any conductive probe. The system uses the inductive probe reading to adjust the resistive element to the correct value. The conductivity probe simulator can be configured to emulate any conductivity probe with any probe constant by downloading configuration parameters to the probe controller or by setting configuration switches on the controller module. Additionally, the inventive probe simulator is equipped with an embedded temperature sensing element, giving the system a capability to perform a temperature correction in the controller section, if necessary.

Abstract: A biosensor system determines the presence and/or concentration of an analyte in a sample using one or more calibrated correlation equations. The analysis may be electrochemical, optical, or a combination thereof. The biosensor system may be implemented using a measurement device and a sensor strip. The measurement device applies test signals to a multi-layered encoding area of the sensor strip. Calibration information is determined from the patterns generated by the interaction of the test signals with the multi-layered encoding area.

Abstract: A base sequence cluster generating system, method, and program product for performing cluster generation is provided. This is accomplished utilizing a computer system having a database containing base sequences which receives a query sequence. The computer uses spliced base sequences as a query sequence to generate a first cluster including base sequences that are likely to constitute a spliced pair with the query sequence. Spliced alignment is applied to the generated first cluster to generate a second cluster including spliced pairs. The generated second cluster is returned to the requester.

Abstract: The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell proliferation, cell cycling and cell death. The multiparameter assay is particularly useful for assessing and screening candidate compounds for anti-cancer utility.

Abstract: A method for characterizing a desired property of a fluid downhole is described. In some non-limiting examples, the method comprises receiving an input signal representing sound speed of a fluid downhole, processing the input signal using a correlation equation expressing the desired property in terms of at least sound speed to produce an output signal representing the desired property, and outputting the output signal. In some examples, the correlation equation is derived through a chemometric analysis of a training data set, the training data set comprises a plurality of input values and a plurality of output values derived from said input values, between the desired fluid property and the first measured property, and the output values are calculated from the input values using a series of correlation equations. In at least one example, the desired property is gas oil ratio. In another example, the desired property is gas brine ratio.

Abstract: In one general aspect, a spectroscopic method is disclosed. This method includes acquiring a plurality of separate spectral measurements at different locations on a sample and evaluating results of the measurements based on one or more predetermined test criteria. Information from measurements made at the different locations is categorized based on results of the step of evaluating, and results are reported that include information from both the step of acquiring and the step of categorizing.

Abstract: A water quality analyzer comprises: sensor electrodes 1a, 1b made of different metals from each other, the electrodes in a liquid of inspecting object generating a sense voltage in proportion to the liquid's impurities concentration; an operational amplifier OP1 amplifying the sense voltage without inverting to provide for a CPU 3; a resistor R0 whose one end is connected to the electrode 1a; and a voltage divider 2 applying a voltage obtained by dividing the sense voltage by a prescribed division ratio to R0's another end. The CPU 3 calculates input signal from OP1 to obtain chlorine concentration and displays the calculated result on a LCD 4 in a measurement mode, and sets the division ratio of the divider 2 so that sense voltage across electrodes 1a, 1b soaked in a liquid including prescribed concentration chloride approximately agrees with a reference voltage of prescribed concentration in a sense-voltage calibration mode.

Abstract: Techniques for analyzing protein structures, such as a tertiary protein structure, are provided. A centroid of the residue centroids is calculated. The centroid of the residue centroids is used as a spatial origin of a global linear hydrophobic moment. The correlation between residue centroid magnitude and residue solvent accessibility is enhanced. The global linear hydrophobic moment is defined, wherein each of the residue centroids contributes a magnitude and direction to the global linear hydrophobic moment. A method for comparing at least two tertiary protein structures is also disclosed.

Abstract: Systems and methods for end-of-life disabling of a diagnostic test system are described. In one aspect, a diagnostic test system that includes a test unit and a disabling unit. The test unit performs at least one diagnostic test on a diagnostic assay to determine whether at least one analyte is present within a sample. The disabling unit determines a measure of current lifetime of the test unit and disables the test unit in response to a determination that the current lifetime measure meets an end-of-life threshold. In a diagnostic test method, at least one diagnostic test is performed on a diagnostic assay to determine whether at least one analyte is present within a sample. A measure of current lifetime of the test unit is determined. The test unit is disabled in response to a determination that the current lifetime measure meets an end-of-life threshold.

Abstract: An electrically active particle is disclosed, having a virus scaffold. Nanoparticles are bonded to the surface of the virus, and the nanoparticles are connected to each other by, molecular wires.

Abstract: A method and system for nuclear substance revealing using muon detection technique is presented. In some aspects, naturally occurred muons are selected from the flow of charged particles. Muon coordinate and incidence angle measured above and below the interrogated volume can be used for the decision making on the presence of nuclear substance inside the volume. The system is adapted for performing measurements on moving objects such as moving trucks. A combination of the nuclear substance detection system with an explosive sensing system is presented.

Abstract: A field-based similarity search system and method includes a database for storing at least one candidate molecule, an input device for inputting a query molecule, and a processor for identifying a candidate molecule which is similar to the query molecule based on a similarity of fragment pair features.

Abstract: The present invention offers an alternative strategy for the correlation of interference information to chemical and/or physical properties of a sample. This strategy can be implemented in a method and a system, which offer substantial technical and commercial advantages over state of the art techniques based on interference spectroscopy. The method comprises the steps of: a. obtaining an interferogram and/or at least one interferogram element corresponding to a modulation of electromagnetic signal emitted from, transmitted onto or through, or having interacted with at least a part of the sample, b. performing i. at least one transformation of the interferogram and/or a segment of the interferogram and/or an interferogram element with at least one function, ii. optionally repeating i) for another segment of the interferogram and/or interferogram element, wherein the transformation does not comprise a Fourier Transformation if i) is conducted only once, thereby obtaining at least one score, c.

Abstract: A method and system are provided to determine fill sufficiency of a biosensor test chamber by determining capacitance of the test chamber.

Abstract: Methods for using modified single wall carbon nanotubes (“SWCNTs”) to detect presence and/or concentration of a gas component, such as a halogen (e.g., Cl2), hydrogen halides (e.g., HCl), a hydrocarbon (e.g., CnH2n+2), an alcohol, an aldehyde or a ketone, to which an unmodified SWCNT is substantially non-reactive. In a first embodiment, a connected network of SWCNTs is coated with a selected polymer, such as chlorosulfonated polyethylene, hydroxypropyl cellulose, polystyrene and/or polyvinylalcohol, and change in an electrical parameter or response value (e.g., conductance, current, voltage difference or resistance) of the coated versus uncoated SWCNT networks is analyzed. In a second embodiment, the network is doped with a transition element, such as Pd, Pt, Rh, Ir, Ru, Os and/or Au, and change in an electrical parameter value is again analyzed. The parameter change value depends monotonically, not necessarily linearly, upon concentration of the gas component.

Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.

Abstract: The present invention provides improved ANOVA methods for analyzing measured data and transformed data. The improved ANOVA method takes two data types as its input, one is the measurements, the other is a predetermined error associated with the measurements. The latter can come from a technology/platform-specific error model. Because of the additional input information, the statistical power is increased. The methods of the invention is particularly useful for analyzing gene or protein expression data.

Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

Abstract: The present invention related to an electronic assay apparatus and a testing method thereof for increasing efficiency and saving power. The electronic assay apparatus for determining a result of an assay performed using a test strip comprises two light sources, one detector and a microprocessor. The two light sources respectively illuminate light incident upon a test zone or a control zone of a test strip. The only one detector disposed between the two light sources and detects light reflected from the test zone and the control zone alternately. The microprocessor compares a calculating result value to only one threshold for showing a result.

Abstract: The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations.

Abstract: Disclosed is a system with which fuel cell stacks can be tested automatically or manually so that production of pollutants and consumption of electricity are little. The system runs various analyses and tests on the fuel cell stacks and provides operative conditions such as temperatures and fluid flows needed in the tests.

Abstract: A method of analyzing data from a mass spectrometer provides data-dependent acquisition. An extracted ion chromatogram (XIC) is created for each m/z data point of mass spectral scans and the XIC for each m/z data point are correlated to a model function to obtain a XIC correlation value. A weighting function is applied to the XIC correlation value to obtain a current weighted intensity for each m/z point, which is used to reconstruct a weighted mass spectrum. The value or range of intensities of interest of the weighted intensity data or raw data is transformed from the time domain into the frequency domain, and the transformed data is used to make a real-time decision for the data-dependent acquisition. The data-dependent acquisition can be the performance of tandem mass spectrometry. A sample processing apparatus receives the sample and a computer readable medium provides instructions to the apparatus.

Abstract: The use of a robust statistical method for self-calibration of a measuring instrument, such as a mass spectrometer, is disclosed. The method involves the use of differences in mass and complementary pairs for example, to estimate calibration parameters. Self-calibration of various mass spectra is described. Related systems and computer-readable media are also described.

Abstract: A meter is provided that includes an improved user interface that enables the user to take a specific action, leading them directly to data input options. Such a user interface could be used to input first selected information, such as whether a test was premeal or postmeal, immediately after receiving a result. Optionally, the user interface may include the ability to add an additional comment after inputting the first selected information. Provision of such a user interface would facilitate simpler capture of the first selected information each time the user performs a test, leading to an enhanced understanding of a patient's level of glycemic control. Designing a user interface to enable first selected information to be entered by a user directly after receiving a result is more likely to engage a patient by making it easy and simple to enter important information. This may enable capture of the information thought to be most pertinent e.g.

Abstract: A method and apparatus for performing time of flight mass spectrometry wherein the number of sums of transients taken for generating a given spectra is determined as a function of a characteristic of the incoming data for that spectrum. For instance, the number of transient measurements taken for a given spectrum output can be determined as a function of the abundance of ions in the sample or the abundance of ions corresponding to a base peak or another selected peak. In yet another embodiment, the collection of transients is terminated when a threshold signal to noise ratio is attained.

Abstract: The invention is applied to an internal combustion engine in which fuel cut control is performed. The internal combustion engine has an exhaust gas recirculation system including: an exhaust gas recirculation passage that connects an intake and exhaust passage of the engine; and an exhaust gas recirculation valve that changes a cross section of the exhaust gas recirculation passage. A correlation, which holds during a predetermined period of time immediately after fuel cut control is stopped, between engine rotation speed NE and an index value indicating the amount of burned gas contained in the recirculated exhaust gas that passes through the exhaust gas recirculation valve (S101 to S104). The correlation is stored in an electronic control unit in advance (S105). Immediately after the fuel cut control is stopped, the index value indicating the burned gas amount is computed from the correlation stored in the electronic control unit based on the engine rotation speed NE.

Abstract: A method and apparatus is provided for determining concentration of components in a liquid hydrocarbon mixture including hydrocarbons and water flowing through an alkylation process. A fluid flow path conveys the liquid continuously from the alkylation process through a first instrument configured for measuring a property of the liquid mixture, and having responsivities to concentration of the components, which are independent of the concentration of the water. A temperature detector generates temperature data for the liquid, and a second instrument measures another property of the liquid mixture. The instruments have mutually distinct responsivities to concentrations of the components.

Abstract: A system for receiving, analyzing and communicating results of sensing chemical and/or physical parameter values, using wireless transmission of the data. Presence or absence of one or more of a group of selected chemicals in a gas or vapor is determined, using suitably functionalized carbon nanostructures that are exposed to the gas. One or more physical parameter values, such as temperature, vapor pressure, relative humidity and distance from a reference location, are also sensed for the gas, using nanostructures and/or microstructures. All parameter values are transmitted wirelessly to a data processing site or to a control site, using an interleaving pattern for data received from different sensor groups, using I.E.E.E. 802.11 or 802.15 protocol, for example. Methods for estimating chemical concentration are discussed.

Abstract: A clinical laboratory apparatus includes a plurality of reaction cuvettes, a first dispenser, a second dispenser, a controller, and an analyzer. A subject sample and a reagent are mixed in each of the plurality of reaction cuvettes. The first dispenser is configured to dispense the subject sample into each of the plurality of reaction cuvettes. The second dispenser is configured to dispense the reagent into each of the plurality of reaction cuvettes so that the subject sample and the reagent are mixed. The controller is configured to categorize the plurality of reaction cuvettes into at least first and second groups, to designate at least first and second analysis items among two or more analysis items with respect to the subject sample, to control the second dispenser to avoid dispensing the reagent relevant to the first analysis item into the second group of the reaction cuvettes. The analyzer is configured to analyze a mixed result.

Abstract: A sample analyzer optically measures reaction of a sample mixed with reagent, and obtains optical information therefrom; generates a reaction curve representing change in the optical information over time; determines a first area prior to an evaluation target time (t0) and a second area after the evaluation target time (t0) wherein the first and second areas are formed between a baseline which is parallel to the time axis and a reaction curve from a first time (t1) prior to the optional evaluation target time (t0) to a second time (t2) after the evaluation target time, and determines the reaction end point based on the first and second areas; and obtains a characteristic of a sample based on the determined reaction end point, is disclosed. a sample analyzing method is also disclosed.

Abstract: Methods for predicting the performance risk of a paint component are disclosed. The methods include providing a proposed paint formulation, wherein the proposed paint formulation comprises at least one paint component, and identifying previous paint formulations comprising the paint component. The methods further include evaluating formulation similarities between the previous paint formulations and the proposed paint formulation, assigning formulation similarity scores based on the formulation similarities, and determining a paint component risk score for the paint component based on the formulation similarity scores. The proposed paint formulation may be utilized in a manufacturing application when the paint component risk score satisfies a manufacturing threshold value.

Abstract: A computer system. The computer system including a processor and memory unit coupled to the processor, the memory unit containing instructions that when executed by the processor implement a method for monitoring a solution in a tank used to fabricate integrated circuits, the method comprising the computer implemented steps of: (a) collecting data indicating of an amount of copper in a region of a substrate of a monitor, the monitor comprising an N-type region in a silicon substrate, the region abutting a top surface of the substrate, the monitor having been submerged in the solution for a preset time; (b) comparing the data to a specification for copper content of the solution; (c) if the data indicates a copper content exceeds a limit of the specification for copper, indicating a corrective action is required to prevent copper contamination of the integrated circuits; and (d) repeating steps (a) through (c) periodically.

Abstract: Methods, systems, and computer program products for generating theoretical mass spectral fragmentation patterns of a chemical structure is provided. The method includes obtaining a description of a chemical structure and generating, from the description, a list of chemical structure information. A binary tree data structure is used to organize the list of chemical structure information. The binary tree data structure may be fragmented by determining, based on a set of predetermined rules, a fragmentation point between two nodes in the binary tree data structure thereby dividing the binary tree data structure into a fragment and a complement. The molecular formula and molecular weight of each fragment is determined. The binary tree data structure is traversed and appropriate fragmentation rules are applied to produce a plurality of theoretical molecular fragments.

Abstract: A genealogical research and record keeping system and method for identifying commonalities in haplotypes and other genetic characteristics of two or more individual members of a biological sample. Chromosomal fragments identical by descent identify family ties between siblings, parents and children and ancestors and progeny across many generations. It is particularly useful in corroborating and improving the accuracy of genealogical data, and identifying previously unknown genetic relationships.