Abstract: A method and kit for determining a concentration of iron in brake fluid when contacting a colorimetric reagent such that a color results. The level of iron can be used to determine the amount of active corrosion within a brake system and determine if special service procedures are required.

Abstract: A method and apparatus is provided for determining concentration of components in a liquid hydrocarbon mixture including hydrocarbons and water flowing through an alkylation process. A fluid flow path conveys the liquid continuously from the alkylation process through a first instrument configured for measuring a property of the liquid mixture, and having responsivities to concentration of the components, which are independent of the concentration of the water. A temperature detector generates temperature data for the liquid, and a second instrument measures another property of the liquid mixture. The instruments have mutually distinct responsivities to concentrations of the components.

Abstract: A method and apparatus for monitoring a fluid that is to be transported through a fluid conduit within a hydrocarbon exploration and production installation is described. A monitoring zone is established upstream of the fluid conduit configured such the fluid supply to the fluid conduit is introduced via the monitoring zone. The fluid supply within the monitoring zone is monitored for the occurrence of events detrimental to the flow of the fluid supply through the fluid conduit. Monitoring the fluid supply prior to entering the fluid conduit allows for the early detection of an event detrimental to the flow of the fluid supply e.g. a chemical reaction indicative of corrosion of the fluid conduit or the formation of a potential blockage within the fluid conduit. In this way the risk of costly blockages or structural failure occurring within the fluid conduit is reduced.

Abstract: Markers are provided that are predictive of Alzheimer's disease. Levels of these markers, when different from a standard, are indicative of a patient being at risk of having or developing Alzheimer's disease.

Abstract: The present invention provides markers and methods for determining whether a subject, particularly a human subject, has or is at risk of developing, a disease such as cardiovascular disease, diabetes mellitus, insulin resistance, metabolic syndrome, NAFLD (Nonalcoholic Fatty Liver Disease) or NASH (Nonalcoholic Steatohepatitis) (e.g., within the ensuing year, two years, and/or three years). The present application also relates to the use of such markers and methods for monitoring the status of such diseases in a subject or the effects of therapeutic agents on subjects with such diseases.

Abstract: A method for improved handling of a blended fuel includes obtaining a sample of the blended fuel from a storage tank; cooling the same until the sample separates into phases; and determining a risk that the fuel in the storage tank will separate based on the cooling step. An apparatus for assessing the risk of phase separation of a blended fuel includes a test cavity for holding a sample of the blended fuel from a storage tank; a heat transfer device for cooling the sample in the test cavity; and at least one sensor for indicating when the sample in the test cavity has separated into phases.

Abstract: The invention relates to body fluid measuring strip cartridges and apparatuses. A cartridge of the present kind comprises a body having a housing zone for a plurality of stacked test strips, a first opening on the wall of the body for bringing the test strips out of the body one at a time, and first means for sealing the first opening. According to the invention, the cartridge further comprises a second opening on the wall of the housing, the second opening allowing an external actuator to enter the housing and to move within the housing for bringing a test strip out of the body, and second means for sealing the second opening. In addition, means are arranged on said body for providing electrical connection between the reading terminals of at least one strip and external meter electronics. The invention offers a convenient way of achieving sealed storage and reading of analytical test strips for small-sized body fluid measuring apparatuses.

Abstract: The present invention is directed, among other things, to using secondary metabolites in the mevalonate pathway (such as, for example, HMG) and/or structurally related compounds to mediate biological activities (e.g., for therapeutic applications) and/or as diagnostic agents. In some embodiments, the biological activities comprise one or more pleiotropic effects of statins (such as, for example, angiogenesis, promoting vascular function, anti-inflammatory action, immunomodulation, etc.). Also provided are methods of screening for mevalonate pathway secondary metabolites, methods of producing HMG, and methods of diagnosing comprising measuring amount of mevalonate pathway secondary metabolites.

Abstract: Non-invasive methods of predicting embryo outcome by analyzing disclosed markers in embryo culture media.

Abstract: The present provides methods for using lipoic acid. In one embodiment, the methods include administering lipoic acid to a female subject in need thereof, wherein at least 10 milligrams lipoic acid per kilogram of body weight is administered. In another embodiment, the methods include administering to a female subject in need thereof an effective amount of lipoic acid, wherein concentration of progesterone in the blood of the subject is increased compared to the subject prior to administration of the lipoic acid. The subject may be pregnant.

Abstract: An adapter for an analyte measuring device for measuring the amount of analyte in a test sample, typically a biological fluid, the device comprising a meter (14) and a test strip (10), the adapter (12) comprising a meter interface (20) for connecting to a meter designed for use with a test strip of one design, and a test strip interface (22) for connecting to a test strip of a different design, and means for adapting the output(s) from the test strip of different design for use by the test meter and/or an output(s) from the test meter for use by the test strip of different design.

Abstract: The present invention provides methods of diagnosing and identifying subjects as having GERD comprising detecting E-cadherin fragments in a biological sample from the subject. The invention further provides methods for identifying subjects as having heartburn that is responsive to proton pump inhibitor therapy and subjects having an increased likelihood of a rapid relapse of GERD after reducing the dosage of PPIs or terminating PPI therapy. In addition, the present invention provides methods for monitoring the healing of erosive and nonerosive esophagitis of GERD without the need for esophagogastroduodenoscopy or esophagogastroduodenoscopy and biopsy, respectively.

Abstract: The present invention relates to methods to identify one or more conditions in a subject. In particular, it relates to methods of identifying a condition such as cancer, which changes a lipid profile in a keratin-containing component of a subject, the changes to the lipid profile being determined by techniques such as chromatography and mass spectrometry.

Abstract: In vitro analyte sensors and methods of analyte determination are provided. Embodiments include sensors that include a pair of electrodes to monitor filling of the sample chamber with sample.

Abstract: A procedure for determining the proportion of components of a fuel mixture, which is boosted with a fuel pump, and a device for implementing the procedure are suggested. A measure for the power input of the fuel pump is detected, with whose aid the proportion of components of the fuel mixture is determined. By proceeding according to the invention a special sensor, which is susceptible to components of the fuel mixture can be waived.

Abstract: Embodiment of the present invention features a device, method and kit for performing one or more processing steps on a sample. The device includes a housing and a processing component. The housing has a first vessel connector for receiving a first vessel and a second vessel connector for receiving a second vessel, and a passage, to provide fluid communication between the first and second vessels. The processing component is in fluid communication with the passage and for effecting a change in a fluid moving from the first vessel to the second vessel through the passage via centrifugal force.

Abstract: An aspect of the present invention relates to a method of analyzing an iron concentration of a boron-doped p-type silicon wafer by a SPV method, which comprises subjecting the wafer to Fe—B pair separation processing by irradiation with light and determining the iron concentration based on a change in a minority carrier diffusion length following the separation processing. The iron concentration is calculated with a calculation equation comprising a minority carrier diffusion length LAF1 measured after the separation processing, a minority carrier diffusion length LAF2 measured after a prescribed time has elapsed following measurement of LAF1, and dependence on time of recombination of Fe—B pairs separated by the separation processing. The calculation equation is derived by assuming that the irradiation with light causes boron atoms and oxygen atoms in the wafer to form a bonded product, and by assuming that the bonded product has identical influences on LAF1 and LAF2.

Abstract: The present invention provides a polymeric scale inhibitor, wherein said inhibitor comprises at least one boron atom.

Abstract: A method for determining the concentration of a chromatographic medium in a liquid slurry comprises the steps of: providing a column (1) having a top end (3) and a bottom end (2) and adapted to retain a chromatographic medium therein; introducing a defined volume of the slurry (15) into the column (1); providing a liquid flow through the column (1) from the top end to the bottom end of the column to settle the chromatographic medium in the column; measuring the bed height of the consolidated chromatographic medium or a value related thereto; and determining from the measured bed height or value related thereto the concentration, or a value related to the concentration of the chromatographic medium in the slurry. A device for performing the method as well as the use of the method in packing of especially large scale columns are also disclosed.

Abstract: A biological information acquisition method includes: measuring an amount of nicotinamide metabolite in a sample collectable from a living organism in a minimally invasive manner; and acquiring information concerning the living organism based on the measured amount of nicotinamide metabolite.

Abstract: The present invention relates to formulations and kits for gastrointestinal cleansing and to therapeutic methods thereof.

Abstract: Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.

Abstract: A sampling apparatus for sampling a fluid from a fluid source includes a first fluid passage device, a second fluid passage device and a fluid by-pass. The first fluid passage device is disposed downstream of and in fluid communication with the fluid source. The second fluid passage device is disposed downstream of and is in fluid communication with the first fluid passage device. The fluid by-pass is disposed downstream of the fluid source and upstream of the second fluid passage device. The fluid by-pass being in fluid communication with and disposed between the fluid source and the second fluid passage device is operative to cause a first portion of the fluid to flow through the first fluid passage device and to cause a second portion of the fluid to by-pass the first fluid passage device and to flow to the second fluid passage device.

Abstract: A pressure vessel having a cell with a locking pin, and a cap and associated methods and systems. The locking pin may be configured to engage the cap when the pressure vessel is pressurized to prevent rotation of the cap without depression of the cap.

Abstract: The present invention provides a dissolution test cell having a chamber and slide valve for dispensing pharmaceutical dosage forms, such as tablets, capsules, and powders, into the chamber without having to open the cell and expose the chamber and its contents to the ambient environment. The present invention also facilitates removal of a partially dissolved or non-disintegrating dosage form from the chamber and cell entirely, without exposing the interior of the cell and chamber. Dissolution test apparatus comprising at least one dissolution test cell in accordance with the invention is also provided, as well as methods for its operation to obtain Level A IVIVC dissolution results which accurately correlate with in vivo dissolution results are also provided.

Abstract: A fluid sensor includes a metal housing body, which has a box and a flanged ring circumferentially surrounding the box. A housing jacket is formed from plastic material and disposed on an exterior side of the housing body. A sealing ring, which is situated circumferentially on top of the flanged ring, subdivides the housing jacket into two sections that are insulated from each other.

Abstract: Antimicrobial silicone-based dressings, such as wound dressings, are disclosed. An example dressing comprises a transparent and self-adhesive gel sheet cured from a liquid containing silicone, the sheet having dispersed therein (i) particulates of a chlorhexidine compound that is not soluble in the liquid; and (ii) at least one other antimicrobial. Methods of making the silicone-based dressings and methods of use are also disclosed.

Abstract: Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy.

Abstract: The process for the diagnosis, early detection and prognosis of the clinical development of autosomal-dominant polycystic kidney disease (ADPKD) comprises the step of determining the presence or absence or amplitude of at least three polypeptide markers in a urine sample, the polypeptide markers being selected from the markers characterized in Table 1 by values for the molecular masses and migration times.

Abstract: Nanostructured sensing substrates (nanodevices) offer greatly enhanced sensitivity and selectivity for detection of molecular species through a variety of sensing modalities. In order to produce repeatable and quantifiable assays, it is desirable to apply the analyte uniformly to the nanodevice. Uniform analyte application is promoted by applying the analyte in a fluid mixture or solution which uniformly wets the nanostructured device. The fluid, or mixture of fluids, is chosen to both wet the nanodevice and dissolve or uniformly suspend the analyte.

Abstract: The present invention describes methods and kits for determining the concentration of free chlorine in water. To avoid false readings from other species present in the water, the free chlorine is reacted with ammonia to form monochloramine, which is then reacted to form an indophenol or an indonaphthol. The concentration of the indophenol or indonaphthol is proportional to the total monochloramine present. Subtracting the concentration of residual monochloramine from the total monochloramine yields the concentration of monochloramine formed from the free chlorine and ammonia, and is proportional to the concentration of free chlorine. Embodiments of the present invention will simplify and accelerate accurate measurements of free chlorine in water, without interference from compounds impacting present measurements of free chlorine.

Abstract: The present invention relates to a method for determining a subject's resistance to treatment with 2,2-dimethyl-N—((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N?-(2,2,3,3,3-pentafluoro-propyl)-malonamide by measuring the levels a biomarker or biomarkers present in a biological sample obtained from the subject, the biomarker being IL6 and/or IL8. The present invention also relates to a combination therapy for a patient suffering from a proliferative disorder comprising administering to the patient 2,2-Dimethyl-N—((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N?-(2,2,3,3,3-pentafluoro-propyl)-malonamide and an anti-IL6 and/or an anti-IL8 agent.

Abstract: A number of methods of analysing honey are described to determine the age of the honey, the presence of fortification with additives including methylglyoxal (MGO), the region from which the honey is derived, the plant species from which the honey is derived and whether the honey has been heated during processing. The various characteristics are determined based on the phenolic concentrations in the honey which have been found to provide very clear markers for the above characteristics. The methods of analysis described have many applications, particularly around quality assurance and ensuring that honeys are true to labeled specifications.

Abstract: An analysis device is proposed for detecting an analyte in a liquid sample, in particular for detecting glucose in a bodily fluid. The analysis device comprises at least one control element, which is configured to provide a function menu with at least two menu items. The analysis device further comprises at least one adjustable selector element, in particular a mechanically adjustable selector element, which can be adjusted by a user to at least two different selection positions. The selector element is configured to remain in the adjusted selection position after being adjusted. The control element is configured to select a menu item corresponding to the adjusted selection position. The analysis device further comprises at least one operating element. At least one parameter in the selected menu item can be influenced by the user via the operating element.

Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.

Abstract: A method for analysing a mixture M comprising (i) a first monodisperse species, and (ii) a second species having a response coefficient which is distinct from the response coefficient of the first species (i) on at least one detection device, said method comprising the following steps: (A) the mixture M is injected at the inlet of a capillary tube and forced to be transported in said tube by the flow of a carrier liquid induced by a positive hydrodynamic and/or hydrostatic pressure between the inlet and the outlet of the capillary, whereby a phenomenon of Taylor dispersion of the species of the mixture M occurs in the tube; (B) by using a detection device able to detect simultaneously both species (i) and (ii) and placed in the region of the outlet of the capillary tube, a signal reflecting the Taylor dispersion obtained in step (A) is measured; (C) the signal obtained in step (B) is analysed, so as to determine specific contributions of species (i) and (ii) and thereby establishing at least one of the follow

Abstract: A water detection system in a fuel delivery system of an engine that helps to limit the occurrence of water related corrosion or damage to various engine components by detecting if a fuel supply has a high level of water content, and providing a notice that appropriate action should be taken. The system includes a fuel filtration module, a water sensor to sense high water content of a fuel supply, and a control device connected to the water sensor and receiving inputs therefrom relating to the water sensed by the sensor. The system also includes an indication source connected to the control device for communicating that a problem with the fuel exists if high water content is detected.

Abstract: A method and kit for determining a concentration of iron in brake fluid when contacting a calorimetric reagent such that a color results. The level of iron can be used to determine the amount of active corrosion within a brake system and determine if special service procedures are required.

Abstract: Presented herein are biomarkers related to breast cancer. The presently identified salivary biomarkers create the basis for a breast cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed breast cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble CD44 antigen, Angiopoietin-1, soluble Angiopoietin-1 receptor, C—X—C chemokine motif 5, soluble Endoglin, soluble Tumor-associated calcium signal transducer 1, Erythropoietin, soluble Fractalkine, Heme oxygenase 1, soluble Interleukin-1 receptor type II, soluble Interleukin-6 receptor subunit-alpha, Lymphotactin, Lymphotoxin-alpha, Stromelysin-1, C—C motif chemokine 22, C—C motif chemokine 5, and Thrombospondin-1 as diagnostic and prognostic biomarkers in renal injuries.

Abstract: The invention provides a method for measuring the levels of 5-methyltetrahydrofolate (5-MTHF), tetrahydrofolate (THF), and 5,10-MTHF in a biological sample. The method includes employing an isotope dilution liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS) methodology.

Abstract: Presented herein are biomarkers related to lung cancer. The presently identified salivary biomarkers create the basis for a lung cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed lung cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis, etc., especially in the context of bone disorders, e.g., conditions associated with low bone mineral density, e.g., osteoporosis.

Abstract: Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature that is indicative of the methods used to make the heparin preparation.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury.

Abstract: An analyzing device includes a feeder connected to a container in which a sample is contained for sucking the sample from the container and feeding the sample, and a controller for performing control for feeding from the feeder to a measurer. In measuring the sample, the controller performs control so that results of a plurality of times of measurement are obtained with respect to the single container in which the sample is contained, without changing the container. This arrangement allows quick accuracy check.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

Abstract: The present invention provides compositions, systems, kits, and methods for preparation prior to a colonoscopy or other gastrointestinal procedure. In particular, the present invention provides a colon lavage system comprising an aqueous portion and a solid portion.

Abstract: The invention relates to methods for the diagnosis of non-alcoholic steatosis (NASH). The method relies on the determination of certain metabolic markers in a biological sample of the patient which are up- or down-regulated in the NASH patients vs. patients with a simple fatty liver (steatosis).

Abstract: The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.