Patents Assigned to SANDOZ
  • Patent number: 4609668
    Abstract: The invention provides novel .alpha.-(ethynyl substituted phenyl)-.alpha.-hydrocarbyl-1H-azole-ethanols wherein the azole group is 1,2,4-triazol-1-yl or imidazol-1-yl, the ethynyl group is unsubstituted or substituted and the phenyl group may bear an additional substituent and ethers thereof, which are useful as fungicides.
    Type: Grant
    Filed: August 24, 1984
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventors: Fritz Schaub, Rupert Schneider
  • Patent number: 4609727
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is nitro or cyano;R.sub.2 is cyano or halo;R.sub.3 is C.sub.1-4 alkyl;R.sub.4 is methyl or ethyl;R.sub.5 is C.sub.1-8 alkyl; andR.sub.6 is --CH.sub.2 CHOHCH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.a R.sub.7, --CH.sub.2 CHOHC.sub.6 H.sub.5, --CH(C.sub.6 H.sub.5)CH.sub.2 OH; --(CH.sub.2).sub.n O--CO--NHR.sub.3, --CH.sub.2 CH(R.sub.4)--O--CO--NHR.sub.3 ; --(CH.sub.2).sub.n --O--CO--R.sub.3, --CH.sub.2 CH(R.sub.4)--O--CO--R.sub.3 or C.sub.2-4 hydroxyalkyl, with the provisos that R.sub.6 may be any of the last three groups only when R.sub.1 and R.sub.2 are both cyano and that R.sub.6 may be C.sub.2-4 hydroxyalkyl also when R.sub.5 is C.sub.1-2 alkyl,whereinR.sub.7 is phenyl; phenyl substituted by 1 or 2 substituents independently selected from hydroxy, chloro, bromo, methyl and C.sub.1-4 alkoxy; benzyl; benzyl substituted by 1 or 2 substituents independently selected from hydroxy, chloro, bromo, methyl and C.sub.
    Type: Grant
    Filed: December 16, 1982
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventor: Klaus Koerte
  • Patent number: 4606770
    Abstract: A hydraulic cement mix including hydraulic cement, aggregate, sufficient water to affect hydraulic setting of the cement, and an additive comprising an N-methylol amide, specifically, tri- or tetramethylolglycoluril alone or in combination with other accelerators of set. The additive is present in an amount sufficient to decrease the time necessary for the hardening of the concrete mix. Generally, the additive is present in a total amount of up to about 4.0% by weight based upon the weight of cement in the mix, usually in an amount of between about 0.01% and about 2.50% by weight of cement. The latter concentration is present when complex combinations of accelerators of set for hydraulic cement are employed.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: August 19, 1986
    Assignee: Sandoz Ltd.
    Inventor: Arthur H. Gerber
  • Patent number: 4604101
    Abstract: Dyeings on hydroxy group- or nitrogen-containing fibres are improved by aftertreatment, simultaneously or sequentially, with (A) a polymeric reaction product of an amine with cyanamide, dicyandiamide, quanidine or bisguanidine and (B) a quaternary polyalkylene polyamine. A synergistic effect between (A) and (B) is observed.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: August 5, 1986
    Assignee: Sandoz Ltd.
    Inventors: Bruno Kissling, Tibor Robinson
  • Patent number: 4602032
    Abstract: A 2-alkyl-9,10-dioxy-4,5,5a,6-tetrahydro-dibenz[cd,f]indole or an acid addition salt thereof is a useful anti-parkinson agent.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: July 22, 1986
    Assignee: Sandoz Ltd.
    Inventor: Rudolf K. A. Giger
  • Patent number: 4599087
    Abstract: Polymeric compounds (A) obtained by the reaction of epihalohydrin with a polyalkylene polyamine are useful as textile treatment agents. As pretreatment agents they improve the color yield of the subsequent dyeing, as aftertreatment agents they improve fastness properties. Certain of the products (A) are novel.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: July 8, 1986
    Assignee: Sandoz Ltd.
    Inventors: Jurg Heller, Bruno Kissling, Tibor Robinson, Salvatore Valenti
  • Patent number: 4594410
    Abstract: Azo dyes of the formula ##STR1## and external salts thereof, wherein F is the residue of a monoazo or disazo compound in 1:1 metal complex form or of a trisazo, disazoazoxy or tetrakisazo compound in metal-free or 1:1 metal complex form,each X is independently --NR.sub.2 --Q--NR.sub.3 R.sub.4 or --NR.sub.2 --Q--N.sup..sym. R.sub.5 R.sub.6 R.sub.7,whereinQ is linear or branched C.sub.2-6 alkylene or --NH--CO--CH.sub.2 --,R.sub.2 is hydrogen or C.sub.1-4 alkyl,each of R.sub.3 and R.sub.4 is independently hydrogen; C.sub.1-6 alkyl; C.sub.2-6 alkyl monosubstituted by cyano or hydroxy in the 2-, 3-, 4-, 5- or 6-position; phenyl(C.sub.1-3 alkyl); phenyl(C.sub.1-3 alkyl) having, on the phenyl ring, 1, 2 or 3 substituents selected from chloro, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; C.sub.5-6 cycloalkyl or C.sub.5-6 cycloalkyl substituted by 1, 2 or 3 C.sub.1-4 alkyl groups or --NR.sub.3 R.sub.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: June 10, 1986
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 4593031
    Abstract: This invention relates to a composition and method for potentiating the antidepressant effect of dibenzocycloheptadiene-type antidepressant agents, for example, nortriptyline, in the treatment of depression, especially geriatric depression, by administering them in combination with an approximately 1:1:1 by weight mixture of dihydroergocryptine (2:1 .alpha.:.beta.), dihydroergocornine and dihydroergocristine.
    Type: Grant
    Filed: June 5, 1985
    Date of Patent: June 3, 1986
    Assignee: Sandoz, Inc.
    Inventors: Robert W. Griffith, Jack Singer
  • Patent number: 4592919
    Abstract: Dry souffle compositions having malto/Dextrin and Zanthan gum and wherein the resulting soufflees have an improved foam structure.
    Type: Grant
    Filed: December 28, 1984
    Date of Patent: June 3, 1986
    Assignee: Sandoz, Inc.
    Inventor: William C. Winters
  • Patent number: 4591635
    Abstract: Metal-free compounds and 1:1 and 1:2 metal complexes of the formula ##STR1## or a 1:2 metal complex of a metal-free compound of said formula and a metallizable azo compound not of said formula, whereineach K is independently a coupling component radical of the pyrazolone-5, 5-aminopyrazole, pyridone, 2,6-diaminopyridine, .beta.-naphthol, acetic acid ester, acetic acid amide or N-substituted N,N-disubstituted aniline series,each K.sub.1 is independently ##STR2## wherein R.sub.3 is hydrogen, C.sub.1-4 alkyl, phenyl or benzyl,R.sub.4 is C.sub.1-4 alkyl, (C.sub.1-4 alkoxy)-carbonyl or --CO--N(R.sub.8).sub.2, wherein each R.sub.8 is independently hydrogen or C.sub.1-4 alkyl,R.sub.5 is amino or hydroxy,R.sub.5a is hydroxy,T is hydrogen, cyano, ##STR3## or (C.sub.1-4 alkyl)carbonyl, wherein R.sub.7, R.sub.10, R.sub.12, Z.sub.a and A.crclbar. are as defined in the specification,each R.sub.1 is independently hydrogen, halo, hydroxy, C.sub.1-4 alkoxy or C.sub.1-4 alkyl, orR.sub.1 and R.sub.
    Type: Grant
    Filed: November 10, 1983
    Date of Patent: May 27, 1986
    Assignee: Sandoz Ltd.
    Inventors: Manfred Greve, Helmut Moser
  • Patent number: 4590282
    Abstract: Dioxolane and benzodioxin derivatives, intermediates therefor, synthesis thereof, and the use of the compounds for the control of pests.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: May 20, 1986
    Assignee: Sandoz Ltd.
    Inventor: Clive A. Henrick
  • Patent number: 4588715
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR2## wherein R.sup.4 is H, lower alkyl or a cation; or a -6-oxotetrahydropyran-2-yl ring of the formula Z": ##STR3## e.g. 4-hydroxy-6-{2-[2-(methyldiphenylsilyl)phenyl]ethenyl]ethyenyl}-tetrahydro -2H-pyran-2-one, (trans, trans). The compounds inhibit cholesterol biosynthesis and are useful as anti-atherosclerotic agents.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: May 13, 1986
    Assignee: Sandoz, Inc.
    Inventor: Robert E. Damon, II
  • Patent number: 4588448
    Abstract: A process for sealing an oxidized aluminium or aluminium alloy surface comprising sealing the surface in the presence of a sealing agent to hinder the formation of a smut layer, the agent being the reaction product of one or more sulphonated aromatic compounds with an aldehyde and/or dimethylolurea or a mixture of formaldehyde and urea. A novel composition comprising the reaction product above and a cobalt or nickel salt may also be used as the above mentioned sealing agent.
    Type: Grant
    Filed: November 8, 1984
    Date of Patent: May 13, 1986
    Assignee: Sandoz Ltd.
    Inventors: Hans-Peter Baumann, Carl T. Speiser, Ernst Weisskopf
  • Patent number: 4588725
    Abstract: 2-Piperazinyl-quinazolines or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic and anti-hypertensive agents.
    Type: Grant
    Filed: November 10, 1983
    Date of Patent: May 13, 1986
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Patent number: 4587292
    Abstract: Metal-free azo compounds of the formula ##STR1## wherein Ra is an aromatic group or an active methylene coupling component radical as defined in the specification,R.sub.t is an arylazo group or a group of the formula --Y--Z, whereinY is a direct bond or a bridging radical, andZ is a basic amino or quaternary ammonium group,R is ##STR2## wherein each of the variables is as defined above or below, X is a direct bond or a bridging radical,x is hydrogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, amino or carboxy,ring B is further unsubstituted or further substituted,d is 0, 1 or 2, andn is 0 or 1,with the provisos that (i) the compounds contain an average of at least 1.3 basic water-solubilizing groups, and (ii) the compounds are free of sulfo groups, and 1:1 and 1:2 metal complexes thereof, which metal-free compounds and metal complexes are useful as dyes for leather and paper.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: May 6, 1986
    Assignee: Sandoz Ltd.
    Inventors: Paul Doswald, Emil Moriconi, Helmut Moser, Horst Schmid
  • Patent number: 4585763
    Abstract: The present invention relates to the use of a compound (a), an oomycetes controlling fungicide having the structure element of formula I ##STR1## in which X is CH or N, in association witha compound (b), selected from CYMOXANIL and Phosetyl-Al in combatting or preventing fungal diseases, and fungicidal composition comprising such compounds.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: April 29, 1986
    Assignee: Sandoz Ltd.
    Inventors: Andre Devoise-Lambert, Ulrich Gisi
  • Patent number: 4582848
    Abstract: This disclosure relates to substituted indolamines, which exhibit anti-diabetic activity, having the formula: ##STR1## where m is an integer from 1 to 4,x represents hydrogen or --OHR represents Ar or ##STR2## and Ar represents ##STR3## R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, R.sub.2 and R.sub.3 each, independently, represent lower alkyl, orR.sub.2 and R.sub.3 together with N represent ##STR4## wherein n is 1, 2 or 3,R.sub.4 represents hydrogen or lower alkyl, andR.sub.5 represents hydrogen or lower alkyl, unsubstituted phenyl or phenyl substituted with fluoro, chloro, lower alkyl or lower alkoxy, oror pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: June 16, 1983
    Date of Patent: April 15, 1986
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4582649
    Abstract: Compounds of formula I ##STR1## in which R.sub.1 is an aliphatic C.sub.6-22 residueR.sub.2 is an optionally substituted salicyl groupeach R.sub.3, independently, is H or an optionally substituted salicyl groupn is 0 or an integer from 1 to 10each X, independently, is --C.sub.2 H.sub.4 -- or --C.sub.3 H.sub.6 --provided that the molecule contains from 1 to 5 optionally substituted salicyl groups in free base, protonized or quaternized form, are useful as dyeing or printing after-treatment agents, particularly to improve the oxidative wet fastness of dyeings or printings on cellulose containing material.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: April 15, 1986
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Baumann
  • Patent number: 4579585
    Abstract: The invention provides novel phenylurea of formula I ##STR1## wherein R.sub.1 is H or CHO,R.sub.2 is H, CH.sub.3 or OCH.sub.3R.sub.3 is a group G.sub.1 of the formula ##STR2## or a group G.sub.2 of the formula CH(CH.sub.3)CH.sub.2 Y in which Y is halogen selected from Cl or F or is CH.sub.3 O andX is H or halogen selected from Cl or Br,the use of these novel compounds as herbicides, compositions for facilitating such use and the preparation of the novel phenylurea.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: April 1, 1986
    Assignee: Sandoz Ltd.
    Inventor: Karl Seckinger
  • Patent number: 4579559
    Abstract: A method for treating a textile substrate comprising cellulosic fibres with an aqueous treatment liquor containing a mixture of(a) a secondary hydrophilic sulphonated n-paraffin containing at least 9 carbon atoms, and(b) an orthophosphoric acid triester, the weight ratio a:b being of from 1.4-4.0:1. This mixture of anionic and non-ionic wetting agents is particularly suitable for use in an aqueous medium having a high electrolyte content.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: April 1, 1986
    Assignee: Sandoz Ltd.
    Inventor: Jose Canela