Patents Assigned to SANDOZ
  • Patent number: 4169893
    Abstract: Anti-allergic 4-hydroxy-naphthpyridine-2(1H)-one-3-carboxylic acids and esters are prepared by reacting a 1,3-dioxo-1-naphth[4,5-b]oxazine with an alkali metal salt of a malonic ester (and hydrolyzing to obtain the acids).
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: October 2, 1979
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4169832
    Abstract: Disclosed are compounds of the formula, ##STR1## wherein THE X's are the same and are hydrogen or --SO.sub.3 M,Y is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, halogen, --COOM or --SO.sub.3 M,K.sub.1 and K.sub.2 are the same or different and are both radicals of a coupling component,Either A.sub.1 is --SO.sub.3 M and one of B.sub.1 and C.sub.1 is --SO.sub.3 M, the other being hydrogen,Or A.sub.1 and C.sub.1 are both hydrogen and B.sub.1 is --SO.sub.3 M, andM is hydrogen or a non-chromophoric cation, their production and use in dyeing anionic dyeable substrates, for example, natural and regenerated cellulose, natural and synthetic polyamides, polyurethanes, polypropylene modified to contain basic groups, anodized aluminum, paper and, particularly, leather. The dyes are well-soluble in water, possess good resistance to acid, have relatively high substantivity especially to paper and leather and give good penetration dyeings with leather.Compounds of the formula ##STR2## wherein Q is --NH.sub.2, --NO.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: October 2, 1979
    Assignee: Sandoz Ltd.
    Inventors: Heinz Wicki, Claude Vogel
  • Patent number: 4169702
    Abstract: Disclosed is an optical brightening process for substrates comprising or consisting of synthetic polyamide in which the optical brightener is applied to the substrate by impregnation followed by heat treatment and wherein the brightener is applied in the presence of a compound or mixture of compounds of formula I,rnh.sub.2 iwherein R is --OH, --NR.sub.1 R.sub.2 or ##STR1## X being O, S or NH, and R.sub.1 and R.sub.2 being, independently, hydrogen, C.sub.1-6 alkyl or C.sub.2-4 hydroxyalkyl,Which compounds are in free base or acid addition salt form or, when R is OH, in O-sulphonic acid form, and preparations for use in such process.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: October 2, 1979
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Emmanuel Hervot, Peter Merk, Horst Schmid, Achim Wiedemann
  • Patent number: 4168142
    Abstract: Disclosed is a textile finishing process in which there is employed, as pH regulator, a compound or mixture of compounds of formula I, ##STR1## in which N IS 0 OR 1,P is 0 or an integer from 1 to 6,Q is 2 or 3,X is a halogen,Each ofY and Z, independently, is hydrogen or halogen, andA is hydrogen, phenyl, C.sub.1-12 alkyl, or a radical of formula (a), (b) or (c), ##STR2## WHERE R IS 1 TO 4,S is 0 or an integer from 1 to 4,X, y z and n are as defined above,With the proviso that p is other than 0 when A is hydrogen or a radical of formula (c).
    Type: Grant
    Filed: February 2, 1978
    Date of Patent: September 18, 1979
    Assignee: Sandoz Ltd.
    Inventors: Emmanuel Hervot, Yves Rene, Alain Verdoucq
  • Patent number: 4167626
    Abstract: Disclosed are compounds of formula I, ##STR1## in which X signifies hydrogen, C.sub.1-4 alkyl, cyano, --COOM, --COOR.sub.1, --CONR.sub.2 R.sub.3, --SO.sub.2 NR.sub.2 R.sub.3, --SO.sub.2 R.sub.1, --SOR.sub.1, --SO.sub.3 R.sub.1 or --SO.sub.3 M,Y signifies hydrogen, C.sub.1-4 alkyl, cyano, --COOM, --COOR.sub.1, --CONR.sub.2 R.sub.3, --SO.sub.2 NR.sub.2 R.sub.3, --SO.sub.2 R.sub.1, --SOR.sub.1, --SO.sub.3 R.sub.1 or --SO.sub.3 M, with the proviso that X and Y do not simultaneously have a significance selected from hydrogen and C.sub.1-4 alkyl,R signifies an aryl radical, unsubstituted or substituted by up to two substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, chlorine, cyano, --COOM, --COOR.sub.1, --CONR.sub.4 R.sub.5, --SO.sub.2 NR.sub.4 R.sub.5, --SO.sub.2 R.sub.1 and --SO.sub.3 M,R.sub.1 signifies C.sub.1-4 alkyl or phenyl,R.sub.2 and R.sub.3, independently, signify hydrogen or C.sub.1-4 alkyl, either R.sub.4 and R.sub.5, independently, signify hydrogen or C.sub.1-4 alkyl,Or R.sub.4 and R.sub.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: September 11, 1979
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Alec V. Mercer, Roger Paver
  • Patent number: 4167629
    Abstract: This invention relates to new di-triazolylstyrene derivatives, useful as optical brighteners for organic polymeric materials, especially when applied to or incorporated in synthetic fibres.
    Type: Grant
    Filed: November 7, 1974
    Date of Patent: September 11, 1979
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Horst Schmid
  • Patent number: 4166800
    Abstract: Microspheres, prepared by the low-temperature e.g., -40.degree. to -100.degree. C., phase separation of a polymer and a core material.
    Type: Grant
    Filed: July 31, 1978
    Date of Patent: September 4, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jones W. Fong
  • Patent number: 4166068
    Abstract: The present invention relates to para-substituted-amino-.beta.,.beta.-dicyano styryl disperse dye compounds having an acyloxy group in an ortho position to the methine group.
    Type: Grant
    Filed: April 18, 1975
    Date of Patent: August 28, 1979
    Assignee: Sandoz Ltd.
    Inventors: Werner Baumann, Ulrich Zirngibl
  • Patent number: 4165314
    Abstract: Mixtures of symmetrical and asymmetrical 1:2 cobalt complexes of compounds of the formulae ##STR1## wherein, EACH R.sub.1, independently, is hydrogen or (C.sub.1-4)alkyl, andEach R.sub.2 and R.sub.3, independently, is hydrogen, halogen, (C.sub.1-4)alkyl or (C.sub.1-4)alkoxy,Which complexes are optionally in salt form and which mixtures are useful for dyeing or printing substrates dyeable with anionic dyes, e.g., natural and synthetic polyamides such as wool, silk and nylon, polyurethanes, polyofefins modified to contain basic groups, leather and metals such as anodically oxidized aluminum.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: August 21, 1979
    Assignee: Sandoz Ltd.
    Inventor: Hanspeter Uehlinger
  • Patent number: 4165374
    Abstract: This invention provides compounds of formula I ##STR1## wherein R.sub.1 is(i) hydrogen or alkyl of 1 to 4 carbon atoms, or(ii) chlorine or bromine, in the 2, 3 or 7 position, or(iii) fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position,R.sub.2 is(i) hydrogen or alkyl of 1 to 4 carbon atoms, or(ii) chlorine or bromine, in the 2, 3 or 7 position, or(iii) fluorine, in the 2 or 3 position, eitherR.sub.3 is a group --COR.sub.4, whereinR.sub.
    Type: Grant
    Filed: July 7, 1978
    Date of Patent: August 21, 1979
    Assignee: Sandoz Ltd.
    Inventors: Franz Troxler, Erik Wiskott
  • Patent number: 4165267
    Abstract: The present invention concerns novel photopolymerizable formulations which comprise a photopolymerizable system in association with a photosensitizing amount of the compound of formula ##STR1## WHEREIN R is an unsubstituted or substituted binuclear aromatic group, e.g. phenoxy phenyl,M is 0, 1 or 2 andHal is halogen.
    Type: Grant
    Filed: March 6, 1973
    Date of Patent: August 21, 1979
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer
  • Patent number: 4165306
    Abstract: Disclosed is mass-dyed linear, saturated, aromatic polyester comprising, as dyestuff, a compound or mixture of compounds selected from those of formulae I and II, ##STR1## wherein R.sub.1 is a radical of formula ##STR2## R.sub.2 is hydrogen or a radical of formula ##STR3## of R.sub.3 and R.sub.3 ', both are hydrogen, or one is hydrogen and the other chlorine or bromine, or both are chlorine or bromine,R.sub.5 is hydrogen, chlorine, bromine or methyl,R.sub.5 ' is hydrogen, chlorine, bromine, nitro or a 4-phenyl, 4-chlorophenyl, 4-bromophenyl or 4-para-nitrophenyl group,R.sub.6 is hydrogen, chlorine or bromineR.sub.6 ' is hydrogen, chlorine, bromine or methyl, andR.sub.7 and R.sub.9 are the same and are chlorine or bromine,With the provisos(i) R.sub.2 is hydrogen when R.sub.1 is a radical (1) or (2) or when R.sub.1 is a radical (3), in which R.sub.5 is phenyl or chloro-, bromo- or nitro-phenyl,(ii) R.sub.3 and R.sub.3 ' are both hydrogen when R.sub.1 is a radical (1), (3) or (4),(iii) R.sub.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: August 21, 1979
    Assignee: Sandoz Ltd.
    Inventors: Rene Moissonnier, Hans Seiler
  • Patent number: 4164583
    Abstract: The present invention provides benz[f]isoindolines, useful in the treatment of aggression, a process for their preparation and compositions containing these compounds.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: August 14, 1979
    Assignee: Sandoz Ltd.
    Inventors: Roland Achini, Wolfgang Oppolzer, Emil Pfenninger
  • Patent number: 4164407
    Abstract: 2-amino-4H-3,1 benzoxazines, e.g. 6-chloro 2-dimethylamino-4H, 3,1-benzoxazine, are useful as herbicides. The compounds may be prepared by reacting an amine with a 2-halomethylphenyl isocyanate.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: August 14, 1979
    Assignee: Sandoz, Inc.
    Inventors: Stewart W. Myers, Homer K. Spencer
  • Patent number: 4164050
    Abstract: Disclosed is a textile treatment process wherein a substrate is supported on one or more arms above a treatment liquor and is passed repeatedly through such liquor, characterised in that at least a part of that part of the substrate supported on the arm or arms and out of contact with the treatment liquor at any given time is heated employing heated air or steam, and that the liquor to goods ratio is in the range of from 5:1 to 15:1, and an apparatus suitable for performing such process.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: August 14, 1979
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Stakelbeck
  • Patent number: 4163057
    Abstract: Compounds of the formula ##STR1## where R.sub.1 is hydrogen or lower alkyl, andR.sub.2 is hydrogen or straight chain lower alkyl, andR.sub.3 is hydrogen, fluoro, chloro, lower alkoxy, lower alkyl or trifluoromethyl, andN is 1, 2, 3, and 4,Which are useful as minor tranquilizers, sleep inducers and muscle relaxants.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: July 31, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4162317
    Abstract: Succinic acid esters of -4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R.sub.1 is hydrogen or halo having an atomic weight of from 19 to 36, andR.sub.2 is hydrogen, chloro or lower alkyl having 1 to 4 carbon atomsAre useful as central nervous system depressants, in particular, as muscle relaxants.
    Type: Grant
    Filed: May 25, 1978
    Date of Patent: July 24, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4160766
    Abstract: Compounds of formula I, ##STR1## wherein either R.sub.1 is hydrogen, halogen, trifluoromethyl or lower alkyl or alkoxy, andR.sub.2 is hydrogen or lower alkoxy, orR.sub.1 and R.sub.2 together are methylenedioxy,R.sub.3 is hydrogen, halogen, trifluoromethyl, lower alkyl or alkoxy or alkylsulphonyl,R.sub.4 is hydrogen, halogen, lower alkyl or alkoxy, andEither(i)R.sub.5 is hydrogen, lower alkyl or hydroxyalkyl, lower alkyl mono-substituted by cycloalkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, lower alkenyl or alkynyl, wherein the multiple bond is in other than the .alpha.,.beta.-position, or phenylalkyl of 7 to 10 carbon atoms, andR.sub.6 is hydrogen, lower alkyl or hydroxyalkyl, or(ii)R.sub.5 and R.sub.6 together with the nitrogen atom to which they are bound are 1-piperidinyl, 1-pyrrolidinyl, 1-morpholinyl, 1-piperazinyl or 1-(4-lower alkyl)-piperazinylAre useful as anti-aggressives and anti-depressives.
    Type: Grant
    Filed: May 17, 1978
    Date of Patent: July 10, 1979
    Assignee: Sandoz Ltd.
    Inventor: John B. Bream
  • Patent number: 4160946
    Abstract: The invention concerns a novel device for measuring the conductivity of a solution, comprising a probe having at least two electrodes for immersion in the solution, and converter means for converting the output from the electrodes which is proportional to the conductivity of the solution into an output having a frequency which is proportional to said conductivity. The converter means may comprise a difference amplifier operating as an oscillator.
    Type: Grant
    Filed: October 13, 1976
    Date of Patent: July 10, 1979
    Assignee: Sandoz Ltd.
    Inventor: Giovanni Frigato
  • Patent number: 4159983
    Abstract: Pure and substantially pure asymmetric 1:2 cobalt complexes of the formula, ##STR1## and mixtures of such complexes, in which X is hydrogen or nitro, either, R.sub.1 and R.sub.2, independently, are hydrogen, (C.sub.1-4)-alkyl, (C.sub.1-4)alkoxy, chlorine, bromine or nitro or R.sub.1 is hydrogen, chlorine or nitro, and R.sub.2 is -SO.sub.2 NR.sub.3 R.sub.4, in which R.sub.1 and R.sub.2 occupy the 4- and 5-positions, either R.sub.3 is hydrogen or unsubstituted or substituted (C.sub.1-4)alkyl, and R.sub.4 is hydrogen or unsubstituted or substituted (C.sub.1-4)alkyl, (C.sub.5-7)cycloalkyl or phenyl, or R.sub.3 and R.sub.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: July 3, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jacky Dore