Patents Assigned to SANDOZ
  • Patent number: 4146643
    Abstract: Halo-, hydroxy-, alkyl- and alkoxy-vincamine derivatives are useful vigilance increasing agents.
    Type: Grant
    Filed: December 2, 1977
    Date of Patent: March 27, 1979
    Assignee: Sandoz Ltd.
    Inventor: Paul Pfaffli
  • Patent number: 4146626
    Abstract: The present invention provides compounds of the formula, ##STR1## wherein R.sub.1 is alkyl (C.sub.1-5),R.sub.2 is alkyl (C.sub.1-5),R.sub.3 is hydrogen or halogen, and either each of R.sub.4 and R.sub.5 is hydrogen, orR.sub.4 and R.sub.5, together, are a bond,Which are useful as sleep-inducing and sleep-prolonging agents.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: March 27, 1979
    Assignee: Sandoz Ltd.
    Inventors: Peter Stutz, Paul Stadler
  • Patent number: 4146540
    Abstract: The present invention concerns certain novel compounds falling under the general formula: ##STR1## WHEREIN R.sub.1, R.sub.2 and R.sub.3 are substituents, e.g. alkyl and Me is hydrogen or a metal cation.The compounds are useful stabilizers of organic material against the degradative effect of heat, oxidation and U.V. light.
    Type: Grant
    Filed: October 21, 1977
    Date of Patent: March 27, 1979
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer, Martin Preiswerk
  • Patent number: 4145549
    Abstract: The present invention provides a novel cyclization process useful for the production of the peptide moiety of an ergotalkaloid.
    Type: Grant
    Filed: January 7, 1977
    Date of Patent: March 20, 1979
    Assignee: Sandoz Ltd.
    Inventor: Paul Stadler
  • Patent number: 4145421
    Abstract: This invention provides a new myotonolytic use of thiazoline, oxazoline and imidazoline derivatives and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: April 21, 1978
    Date of Patent: March 20, 1979
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Patent number: 4144337
    Abstract: The invention provides compounds of formula I, ##STR1## wherein each of R.sub.1 and R.sub.4, which may be the same or different, is hydrogen, halogen, alkyl or alkoxy; each of R.sub.2 and R.sub.3 is hydrogen, or together, oxygen; B and D together with the carbon atoms to which they are bound may be a benzene ring or a substituted or unsubstituted thiophene ring and A may, for example, be oxygen, sulpur, --CH.sub.2 --O--, --CH.sub.2 --S, ethylene or vinylene, useful as psychostimulants and vigilance-increasing agents.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: March 13, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Patent number: 4143143
    Abstract: Compounds of formula I, ##STR1## wherein either R.sub.1 is hydroxy or alkoxy of 1 to 4 carbon atoms, and R.sub.2 is hydrogen, hydroxy or alkoxy of 1 to 4 carbon atoms,Or R.sub.1 and R.sub.2, together, are methylenedioxy,R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.4 is phenyl or phenyl substituted by 1, 2 or 3 substituents independently chosen from halogen, hydroxy, nitro or alkyl(C.sub.1-4) haloalkyl(C.sub.1-4), or alkoxy (C.sub.1-4),are useful as anti-arrhythmic agents.
    Type: Grant
    Filed: September 23, 1977
    Date of Patent: March 6, 1979
    Assignee: Sandoz Ltd.
    Inventor: Max-Peter Seiler
  • Patent number: 4143101
    Abstract: This invention relates to the production of phosphorus derivatives with a 5,5-bis-(halomethyl)-1,3,2-dioxaphosphorinane structure and to their use as flameproofing agents for plastics and textile fibres.
    Type: Grant
    Filed: September 14, 1971
    Date of Patent: March 6, 1979
    Assignee: Sandoz Ltd.
    Inventors: Horst Mayerhoefer, Rainer Wolf
  • Patent number: 4142043
    Abstract: The present invention relates to compounds of formula I, ##STR1## in which R.sub.1 signifies a divalent, mono- or binuclear aromatic radical of the carbocylic or heterocyclic series, R.sub.2 signifies a hydrogen atom or an unsubstituted or substituted (C.sub.1-4)alkyl, phenyl, naphthyl or mono-or fused binuclear heterocyclic radical which is bound through a carbon atom, R.sub.3 signifies an oxygen atom or a group of formula >N--R.sub.5 in which R.sub.5 has one of the significances given above for R.sub.2, and each of the R.sub.4 's independently, signifies a mono- or binuclear aromatic radical of the carbocyclic or heterocyclic series,Or mixtures of such compounds, which compounds and mixtures are useful as colorants.
    Type: Grant
    Filed: June 27, 1977
    Date of Patent: February 27, 1979
    Assignee: Sandoz Ltd.
    Inventor: Werner Koch
  • Patent number: 4141889
    Abstract: Symmetrical hexakisazo compounds of the formula ##STR1## and mixtures of such compounds, WHEREINEach X is hydrogen or --SO.sub.3 M,each R.sub.1 is --OH or --NH.sub.2,each R.sub.2 is --OH or --NH.sub.2,each Y is hydrogen, methyl, or --SO.sub.3 M, andEach M, independently, is hydrogen or a non-chromophoric cation,Their production, dye compositions containing them, and their use in the dyeing of cellulosic substrates such as cotton and paper.
    Type: Grant
    Filed: July 27, 1977
    Date of Patent: February 27, 1979
    Assignee: Sandoz Ltd.
    Inventor: Zdenek Allan
  • Patent number: 4140762
    Abstract: This invention provides a novel sub-unit vaccine comprising a mixture of the hemagglutinin and neuraminidase components of the virus in the substantial absence of non-essential viral particles.
    Type: Grant
    Filed: September 23, 1977
    Date of Patent: February 20, 1979
    Assignee: Sandoz Ltd.
    Inventors: Helmut Bachmayer, Gerhard Schmidt
  • Patent number: 4140859
    Abstract: Imidazo[2,1-a]isoquinolines useful as anorexics and antidepressants are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.
    Type: Grant
    Filed: April 13, 1978
    Date of Patent: February 20, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4140684
    Abstract: Dyes of the formula ##STR1## wherein R.sub.1 is a carbocyclic or heterocyclic diazo component radical,R.sub.2 is cyano or acyl,R.sub.3 is alkyl, carbocyclic aryl or heterocyclyl, or a substituted deriive thereof, andR.sub.4 is hydrocarbyl or substituted hydrocarbyl, with the proviso that R.sub.4 is free of sulfo groups and protonizable groups, are useful as disperse dyes for the dyeing and printing of fibres and textiles of synthetic and semi-synthetic, hydrophobic organic substances of high molecular weight. These dyes build up excellently and yield dyeings which are fast to thermofixation, sublimation, pleating, ozone, rubbing, gas fumes, water, sea water, perspiration, alkali and washing.
    Type: Grant
    Filed: April 3, 1975
    Date of Patent: February 20, 1979
    Assignee: Fidelity Union Trust Company, Executive Trustee under the Sandoz Trust
    Inventors: Hermann Burkhard, Roland Entschel, Willy Steinemann
  • Patent number: 4139478
    Abstract: The present invention concerns an application liquor for a novel method of antistatically treating synthetic, semi-synthetic or natural porous material, particularly fibrous material, which comprises a polychlorohydrin ether of tris-(hydroxymethyl)-aminomethane and a polyglycol diamine in an admixture and/or in partially condensed form.
    Type: Grant
    Filed: September 8, 1977
    Date of Patent: February 13, 1979
    Assignee: Sandoz Ltd.
    Inventor: Richard Hochreuter
  • Patent number: 4139689
    Abstract: The invention concerns polymeric basic amides produced by reacting a polymer containing carboxyl groups and a polyamine which contains an alkyl or alkenyl radical of 11 to 22 carbon atoms, at least one ethylene or propylene radical and at least two nitrogen atoms, of which at least one forms a primary or secondary amino group, at a temperature over 100.degree. C., which in the form of their acid salts are water-dispersible and useful textile softeners.
    Type: Grant
    Filed: March 14, 1977
    Date of Patent: February 13, 1979
    Assignee: Sandoz Ltd.
    Inventors: Richard Hochreuter, James R. Runyon
  • Patent number: 4138414
    Abstract: The present invention relates to 2-phenoxy or 2-phenylthio anthraquinone compounds which bear a group of formula VI, ##STR1## bound to the para position of the phenoxy or phenylthio group, IN WHICH R.sub.3 is hydrogen; (C.sub.1-6)alkyl; (C.sub.1-3)alkyl monosubstituted by hydroxyl, cyano, (C.sub.1-2)alkylcarbonyloxy, (C.sub.1-2)alkoxycarbonyl or (C.sub.1-2)alkoxycarbonyloxy; (C.sub.2-6)alkenyl; phenyl; or tolyl;R.sub.4 is --(CH.sub.2).sub.n -- or --CH(R.sub.10)--,R.sub.5 is (C.sub.2-6)alkylene;--R.sub.11 --O--R.sub.12 -- or --CH.sub.2 CH.sub.2 --0--CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 --,R.sub.6a is (C.sub.1-12)alkyl; (C.sub.1-12)alkyl monosubstituted by chlorine, bromine or hydroxyl; unsubstituted phenyl(C.sub.1-2)-alkyl, (C.sub.5-7)cycloalkyl or phenyl; or phenyl or phenyl(C.sub.1-2)alkyl in which the phenyl ring is monosubstituted by chlorine, bromine or methyl,R.sub.10 is (C.sub.1-6)alkyl or phenyl,Each of R.sub.11 and R.sub.12, independently, is (C.sub.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: February 6, 1979
    Assignee: Sandoz Ltd.
    Inventor: Werner Baumann
  • Patent number: 4138565
    Abstract: Solutions of certain hydrogenated ergopeptide alkaloids in mixtures of pharmacologically acceptable alcohols and water have improved stability. Preferred solvents are mixtures of ethanol, propylene glycol and glycerol containing from 15-40% wt. of water and having dielectric constants between 34 and 46. With these solutions it is not essential to carry out the filing operation under an inert atmosphere.
    Type: Grant
    Filed: September 15, 1977
    Date of Patent: February 6, 1979
    Assignee: Sandoz Ltd.
    Inventors: Lothar Ehrhardt, Ludwig Patt, Volker Hartmann
  • Patent number: 4137331
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, andR is the group A, B, C or D, ##STR2## wherein N IS THE NUMBER 2 OR 3,n' is the number 1, 2, 3 or 4, andX-x' is ethylene or vinylene,Wherein in group D each of the two C atoms adjacent to the N atom are identically substituted by hydrogen or by one or two alkyl groups of 1 to 4 carbon atoms useful as antiarrhythmic agents.
    Type: Grant
    Filed: December 16, 1976
    Date of Patent: January 30, 1979
    Assignee: Sandoz Ltd.
    Inventors: Richard Berthold, Franz Troxler
  • Patent number: 4137323
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, halogen of atomic number from 9 to 35 or lower alkyl,R.sub.2 is hydrogen or lower alkyl, each ofR.sub.3 and R.sub.4 is hydrogen, orR.sub.3 and R.sub.4 together are oxygen,N is 2, 3 or 4, andA is ethylene or vinylene,Useful as antiphlogistics and anti-arthritics.
    Type: Grant
    Filed: June 24, 1977
    Date of Patent: January 30, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Patent number: 4137064
    Abstract: .beta.-Haloethanephosphonates and thio derivatives thereof of formula, ##STR1## where X signifies chlorine or bromine,Y signifies oxygen or sulphur, andZ signifies a carboxylic acid ester or carbamoyl group, or an optionally further substituted methyl or ethyl group substituted by such a group, or signifies an acylmethyl, optionally aryl-substituted alkenyl or alkynyl, cyclic ether, e.g. tetrahydropyranyl, or optionally mono-substituted cyanomethyl group, or signifies an alkyl-, cyclo-alkyl- or aryl-thio, -sulphinyl or -sulphonyl group, or an optionally further substituted methyl or ethyl group substituted by such a group, or signifies a sulphonic acid ester group, or an optionally further substituted methyl or ethyl group substituted by such a group,Are useful as regulators of plant growth or plant secretion, especially as stimulators of latex flow in latex-forming plants.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: January 30, 1979
    Assignee: Sandoz Ltd.
    Inventor: Werner Trueb