Patents Assigned to SANDOZ
  • Patent number: 4160032
    Abstract: Sleep inducers of the formula: ##STR1## wherein R is hydrogen or halo of atomic weight of from 18 to 36, R' is hydrogen, halo or CF.sub.3 and R.degree. is hydrogen or lower alkyl. Preparation by cyclizing a 2-nitro-phenylacetic acid is also disclosed.
    Type: Grant
    Filed: November 18, 1974
    Date of Patent: July 3, 1979
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4158735
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: June 19, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4155357
    Abstract: Normal breathing cycles of a ventilator cause an alarm controller circuit to emit a periodic pulse which resets a timer circuit thereby maintaining an alarm device in an "off" condition. Patient disconnect is sensed by an alarm trigger circuit which sends an inhibit pulse to the controller circuit inhibiting the timer circuit reset pulse. This causes the timer to "time out" thereby turning on an alarm actuator circuit which causes an audible and/or visual alarm condition.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: May 22, 1979
    Assignee: Sandoz, Inc.
    Inventor: William R. Dahl
  • Patent number: 4155903
    Abstract: Disclosed are homogeneous complexes of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl or substituted phenyl, ##STR2## WHEREIN ONE Q is hydrogen and the other is sulfo, and N IS 0 OR 1 (THE SULFO GROUP BEING IN THE 5- OR 6-POSITION WHEN N IS 1),R.sub.4 is hydrogen, alkyl, alkoxy, chloro, bromo or nitro,R.sub.5 is hydrogen, alkyl, alkoxy, chloro, bromo, nitro or sulfo,With the proviso that when one of R.sub.4 and R.sub.5 is hydrogen, the other is other than hydrogen and is in the 4- or 5-position and when both are other than hydrogen, one is in the 4-position and the other is in the 5- or 6-position,One of R.sub.6 and R.sub.7 is hydrogen, chloro or nitro and the other is hydrogen, sulfamoyl or substituted sulfamoyl, and ##STR3## wherein one of R.sub.10 and R.sub.11 is hydrogen and the other is hydrogen, chloro, alkyl, alkoxy or trifluoromethyl,R.sub.12 is hydrogen or methyl,R.sub.13 is methyl, chloro or bromo, with the proviso that R.sub.12 is hydrogen when R.sub.13 is chloro or bromo,Y.sub.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: May 22, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jacky Dore
  • Patent number: 4154928
    Abstract: An improved process for the preparation of substituted isoxazolo[4,5-c]pyridin-4(5H)-ones which are either useful as intermediates in the preparation of compounds having pharmaceutical activity or as hypolipidemic agents which comprises cyclizing a corresponding 5-(2-amino-2-phenyl- or substituted phenyl-ethenyl)-3-substituted-N-alkyl isoxazole-4-carboxamide under acidic conditions.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: May 15, 1979
    Assignee: Sandoz, Inc.
    Inventors: Max Denzer, Joseph A. Smith
  • Patent number: 4154691
    Abstract: Flameproofed cellulose includes as a flameproofing agent a compound selected from esters, ester-amides and amides of pyrophosphoric, of mono-, di- and trithiopyrophosphoric, of triphosphoric, and of mono-, di-, tri- and pentathiotriphosphoric acids.
    Type: Grant
    Filed: September 12, 1977
    Date of Patent: May 15, 1979
    Assignee: Sandoz Ltd.
    Inventors: Claudine Mauric, Rainer Wolf
  • Patent number: 4152435
    Abstract: The present invention provides a pharmaceutical composition incorporating as active agents:(a) a pyridazine anti-hypertensive agent, and(b) N-amidino-2-(2,6-dichlorophenyl)acetamide.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: May 1, 1979
    Assignee: Sandoz Ltd.
    Inventor: Roland Salzmann
  • Patent number: 4151139
    Abstract: The invention provides novel polyaddition products of polyglycol diepoxides and polyamine derivatives, which products are useful as antistatic agents.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: April 24, 1979
    Assignee: Sandoz Ltd.
    Inventor: Richard Hochreuter
  • Patent number: 4150942
    Abstract: 1:2 Metal complexes of the formula ##STR1## in which EACH A is, independently, a 1,2-phenylene or 1,2-naphthylene diazo component radical which is unsubstituted or substituted by up to two substituents selected from (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, halogen, nitro, sulpho and carboxy,Q is a group of the formula --N.dbd.N--B or --NHR.sub.3,each B is, independently, a coupling component radical of the aliphatic series containing an enolic hydroxy group, a coupling component radical of the naphthol series free of amino groups or a coupling component,Each X is, independently, --O-- or --COO--, radical of the benzene series having at least one phenolic hydroxy group and/or a group of the formula --NR.sub.1 R.sub.2, with the proviso that when Q is --NHR.sub.3, B is a radical of the benzene series,R.sub.1 is hydrogen, (C.sub.1-6)alkyl or (C.sub.2-4)hydroxyalkyl,R.sub.2 is hydrogen, (C.sub.1-6)alkyl, phenyl, (C.sub.1-6)alkylphenyl or (C.sub.2-4)hydroxyalkyl,R.sub.
    Type: Grant
    Filed: May 27, 1977
    Date of Patent: April 24, 1979
    Assignee: Sandoz Ltd.
    Inventors: Herbert Holliger, Heinz Wicki
  • Patent number: 4150230
    Abstract: 1,4-Diaminoanthraquinone derivatives containing a halopyrimidinyl or haloquinoxaline-6-carbonyl reactive group are useful as reactive dyestuffs for the dyeing or printing of leather and textile materials.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: April 17, 1979
    Assignee: Sandoz Ltd.
    Inventors: Roland Mislin, Wolfgang Schoenauer, Karl U. Steiner
  • Patent number: 4150136
    Abstract: The present invention provides novel compounds of the formula, ##STR1## wherein R.sub.1 is hydrogen, halogen, alkyl or alkoxy; R.sub.2 may, for example, be hydrogen, alkyl, alkenyl, alkinyl or phenylalkyl, the phenyl ring of which may be mono-substituted with halogen, alkyl or alkoxy; and R.sub.3 is hydrogen, alkyl, thienyl, phenyl or phenyl which may be mono- or di-substituted with halogen, alkyl, alkoxy or alkylthio, useful, for example, as anti-depressants and analgesics.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: April 17, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Patent number: 4149851
    Abstract: Concentrated, liquid preparations of metal-free direct azo dyes, which contain in each instance 1 part by weight of dye, 1 to 8 parts by weight of water, and 0.5 to 5 or preferably 0.5 to 2 parts by weight of an amide are useful for dyeing paper in the stock and for dyeing paper sheet.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: April 17, 1979
    Assignee: Fidelity Union Trust Company, Executive Trustee under Sandoz Trust
    Inventors: Alfred Frei, Georg Schoefberger, August Schweizer
  • Patent number: 4148782
    Abstract: Flameproofed polymeric organic materials include as a flameproofing agent a compound selected from esters, ester-amides and amides of pyrophosphoric, of mono-, di- and trithiopyrophosphoric, of triphosphoric, and of mono-, di-, tri- and pentathiotriphosphoric acids.
    Type: Grant
    Filed: September 12, 1977
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventors: Claudine Mauric, Rainer Wolf
  • Patent number: 4148890
    Abstract: The invention provides a synergistic composition of a polyether antibiotic and a pleuromutilin derivative, which has an enhanced effect against coccidiosis in poultry. The composition may be prepared in the form of a premix concentrate and incorporated into commercial complete poultry feed. A method of treatment or prophylaxis of coccidiosis in poultry by co-administration of the components is also claimed.
    Type: Grant
    Filed: December 20, 1977
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventors: Rudolf Czok, Josef G. Meingassner, Hubert Mieth, Eberhard Schutze
  • Patent number: 4148791
    Abstract: Compounds of the formula ##STR1## in which R.sub.1 is --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CHOHCH.sub.2 OH, --CH.sub.2 COCH.sub.3, --CH.sub.2 COC.sub.6 H.sub.5, --CH.sub.2 COC.sub.6 H.sub.4 Br or --NR.sub.8 R.sub.9,R.sub.2 is halogen or cyano,One of R.sub.3 and R.sub.3 ' is hydrogen and the other is hydrogen or halogen,R.sub.4 is hydrogen, chloro, bromo, methyl, methoxy or ethoxy,R.sub.5 is chloro, bromo, cyano, acylamino, methyl, methoxy or ethoxy, with the proviso that, when R.sub.5 is methyl, methoxy or ethoxy, R.sub.1 is other than --NR.sub.8 R.sub.9,R.sub.6 is (C.sub.1-4) alkyl or (C.sub.2-4) alkenyl,R.sub.7 is (C.sub.1-4) alkyl, (C.sub.2-4) alkenyl or phenyl (C.sub.1-2) alkyl,R.sub.8 is hydroxy (C.sub.2-3) alkyl, andR.sub.9 is hydrogen, (C.sub.1-4) alkyl, hydroxy (C.sub.2-3) alkyl or cyano (C.sub.
    Type: Grant
    Filed: September 6, 1977
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventor: Ruedi Altermatt
  • Patent number: 4148807
    Abstract: The present invention concerns a novel process for preparing derivatives useful in the production of prostaglandins.The present invention provides a process for the production of a compound of formula I ##STR1## wherein R.sub.1 is a protecting group which comprises hydrolyzing a compound of formula II ##STR2## wherein R.sub.1 is as defined above and R.sub.2 is a leaving group, under acidic conditions.
    Type: Grant
    Filed: December 2, 1977
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventor: Peter Funfschilling
  • Patent number: 4148916
    Abstract: The invention provides oxaminic acids and esters thereof, useful for the treatment of allergic conditions, a process for the preparation of said compounds and pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventor: Trevor G. Payne
  • Patent number: 4147508
    Abstract: Disclosed is a process for the production of a simultaneously dyed and bonded polyamide fibre band which comprises saturating an untwisted polyamide fibre band with an aqueous liquor containing dyestuff and malic, tartaric or citric acid, applying pressure to the band to compact same and remove excess liquor, and subjecting the compacted band to elevated temperatures to cause bonding and dye fixation.
    Type: Grant
    Filed: September 26, 1977
    Date of Patent: April 3, 1979
    Assignee: Sandoz Ltd.
    Inventor: Max Perrig
  • Patent number: 4147789
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring carbon atom and having 1, 2 or 3 hetero ring atoms, the first hetero atom being nitrogen, oxygen or sulphur, and the second and third hetero atoms, if present, being nitrogen, or 2- or 4-pyridyl monosubstituted by lower alkyl, lower alkoxy or halogen,Useful as anti-Parkinson agents.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: April 3, 1979
    Assignee: Sandoz Ltd.
    Inventors: Peter Stutz, Paul Stadler
  • Patent number: 4147636
    Abstract: Flameproofing composition comprises an O,O,O-triester of phosphorus, phosphoric or thiophosphoric acid and a haloalkyl aryl ether, and optionally a chlorinated aliphatic hydrocarbon and/or an organic tin or lead compound. The composition is useful for flameproofing polymeric organic materials, especially synthetic polymeric organic materials such as polypropylene, which may alternatively be flameproofed by treatment separately with the individual components of the composition.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: April 3, 1979
    Assignee: Sandoz Ltd.
    Inventors: William O. Drake, Hans-Werner Finck, Horst Mayerhoefer, Wolfgang H. Mueller