Abstract: Hypolipidemic agents of the formula: ##STR1## wherein X is C.dbd.O or CHOH,R.degree. is branched lower alkyl,R is hydrogen, alkyl, or halo,n is 1 or 2, andR' and R" are hydrogen, halo, alkyl or alkoxy, e.g., 4-phenoxy-pivalophenone.
Abstract: The present invention relates to the use of the known compounds of formula ##STR1## wherein R is lower alkyl, as mood elevating agents for geriatric patients.
Abstract: Disclosed are compounds of formula I, ##STR1## in which either R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each signifies a hydrogen atom, a chlorine or fluorine atom, an alkyl radical of 1 to 4 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms, a cyano group, a group --SO.sub.3 M, an unsubstituted phenyl radical or a phenyl radical substituted by up to 2 substituents selected from chlorine, fluorine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms and the group --SO.sub.3 M, with the proviso that only one of R.sub.1, R.sub.2 and R.sub.3 signifies an unsubstituted or substituted phenyl radicalOr two of R.sub.1 , R.sub.2 and R.sub.3, together, form a methylenedioxy group, the other of R.sub.1, R.sub.2 and R.sub.3 having one of the above significances,R.sub.4 signifies a hydrogen atom, a chlorine or fluorine atom, an alkyl radical of 1 to 4 carbon atoms or an alkoxy radical of 1 to 4 carbon atoms,R.sub.
Type:
Grant
Filed:
May 5, 1976
Date of Patent:
April 18, 1978
Assignee:
Sandoz Ltd.
Inventors:
Alec Victor Mercer, Peter Stuart Littlewood, Ivan Joseph Bolton, Fritz Fleck
Abstract: Stabilized dye compositions comprising a dye of the formula ##STR1## OR A SALT THEREOF, WHEREIN EACH Me is copper or nickel,Y is optionally substituted arylcarbamoyl,Z is lower alkyl, orY and Z taken together and with the carbon atoms to which they are joined form a naphthalene or heterocyclic ring,m is 1 to 3, andn is 1 or 2,With the proviso that the sum of m and n is 3 to 5,And, as a stabilizer therefor, an amino ether of the formula ##STR2## or a mixture thereof, WHEREIN R.sub.1 is hydrogen, alkyl of 1 to 3 carbon atoms or--R.sub.8 --O--R.sub.9).sub.t' OHeach R.sub.2 is hydrogen, alkyl of 1 to 3 carbon atoms or--R.sub.8 --O--R.sub.9).sub.u' OH,r.sub.4 is hydrogen, alkyl of 1 to 3 carbon atoms or--R.sub.8 --O--R.sub.9).sub.v' OH,each R.sub.5 is hydrogen, alkyl of 1 to 3 carbon atoms or--R.sub.8 --O--R.sub.9).sub.w' OH,each R.sub.3, R.sub.6, R.sub.7, R.sub.8 and R.sub.
Abstract: Pivaloyl benzyl ureas, e.g., 1,1-bis(4-pivaloylbenzyl)-3-methyl urea, are prepared by reacting a corresponding 4",4'"-iminodimethylene-di-tert. alkylophenones with an alkyl isocyanate, and are useful as hypolipidemic agents.
Abstract: Compounds of the formula ##STR1## wherein EACH OF D.sub.1 and D.sub.2 is independently a diazo component radical, e.g., phenyl, naphthyl, thiazolyl, benzothiazolyl or benzoisothiazolyl, or a substituted derivative thereof,R.sub.1 is divalent hydrocarbyl or substituted hydrocarbyl or a hetero atom-, carbonyl group- or sulfonyl group- containing derivative thereof, e.g., an optionally substituted alkylene, cycloalkylene or phenylene radical, andEach of R.sub.2, R.sub.3, R.sub.4 and R.sub.5 is independently hydrogen, cyano, hydrocarbyl or substituted hydrocarbyl or a hetero atom- containing derivative thereof, --COR.sub.6, --CO.sub.2 R.sub.6, --SO.sub.2 R.sub.6, --CONR.sub.7 R.sub.8 or --SO.sub.2 NR.sub.7 R.sub.8,whereinEach R.sub.6 is independently hydrocarbyl or substituted hydrocarbyl or a hetero atom-containing derivative thereof, andEach R.sub.7 and each R.sub.8 is independently hydrogen or R.sub.6.
Abstract: Disclosed are compounds of the formula, ##STR1## or WHEREIN D is, ##STR2## X is --COOM or --SO.sub.3 M, R.sub.1 and R.sub.2, independently, are hydrogen, halogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxy,m is 1, 2 or 3, and, when 3, the two sulpho groups are other than on adjacent carbon atoms,n is 1 or 2,With the proviso that the sum of n + m is 3 or 4,R.sub.3 is hydrogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxy,R.sub.4 is hydrogen or C.sub.1-3 alkyl,R.sub.3 and R.sub.4, when both other than hydrogen, being in para position relative to each other,R is hydrogen or, ##STR3## it being hydrogen only when D is, ##STR4## in which the --COOM group is m- or p- to the azo linkage, R.sub.5 is --CHR.sub.6 --CHR.sub.6 --O--CHR.sub.7 CH.sub.2 O--.sub.p H,either both R.sub.6 's are hydrogen, or one of the R.sub.6 's is hydrogen, the other methyl or ethyl,R.sub.7 is hydrogen, methyl or ethyl,R.sub.8 is hydrogen, C.sub.1-6 alkyl or--CHR.sub.6 --CHR.sub.6 --O--CHR.sub.7 CH.sub.2 O--.sub.q H,Y is --NR.sub.9 R.sub.10 or --N(R.sub.
Abstract: 2-Sec.-alkylaminobenzophenones are prepared by reacting a corresponding 2-aminobenzophenone with a ketone, a borohydride and carboxylic acid.
Type:
Grant
Filed:
January 29, 1976
Date of Patent:
April 11, 1978
Assignee:
Sandoz, Inc.
Inventors:
William J. Houlihan, Paul G. Mattner, Joseph A. Smith
Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methylene-2 or 3 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methylene-5H-dibenzo[a,d]cyclohe ptene, prepared by various methods including acid dehydration of the corresponding dibenzo[a,d]cycloheptene-5-ols. The compounds are useful as anti-depressants.
Abstract: Disclosed are anionic optical brightening agents, such agents being 1,3-diphenyl pyrazolines characterized by having, in the 4- or 5-position of the pyrazoline ring, a sulphoalkyl substituent, their production and use.
Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, halogen of an atomic number from 9 to 35, or alkyl or alkoxy of 1 to 4 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkynyl of 3 to 6 carbon atoms, in which the multiple bond is located in a position other than the .alpha.,.beta. position, hydroxyalkyl of 2 to 5 carbon atoms in which the hydroxy group is separated from the nitrogen atom of the tricyclic ring system by at least 2 carbon atoms, alkanoylalkyl of 3 to 5 carbon atoms, or phenylalkyl of 7 to 10 carbon atoms in which the phenyl ring is unsubstituted or mono-substituted by halogen of atomic number 9 to 35, or alkyl or alkoxy of 1 to 4 carbon atoms, andEitherR.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms, or phenylalkyl of 7 to 10 carbon atoms in which the phenyl ring is unsubstituted or mono-substituted by halogen of atomic number from 9 to 35, or alkyl or alkoxy of 1 to 4 carbon atoms, andR.sub.4 is hydrogen,OrR.sub.3 and R.sub.
Abstract: Disclosed are azo dyes containing a diazo component radical of the formula ##STR1## wherein each of Z and Z.sub.1 is independently hydrogen or sulfo,With the proviso that at least one of Z and Z.sub.1 is hydrogen,For example monoazo and disazo dyes of the formula ##STR2## and salts thereof, WHEREINK is a coupling component radical of the aromatic carbocyclic, active methylene group-containing aliphatic or aromatic heterocyclic series, andZ and Z.sub.1 are as defined above, with the proviso that the dyes contain one or two sulfo groups, and the use thereof for the dyeing and printing of anionic dyeable substrates, particularly polyamide substrates.
Abstract: The compounds are 1-aryl-1-lower alkyl-substituted-1-buten-3-ols, butan-3-ols, and acylation products thereof, e.g., (p-biphenylyl)-2-penten-4-ol and are useful as pharmaceuticals.
Abstract: The present invention concerns a pesticidal formulation which comprises, in admixture, a pesticidal agent, an anionic or non-ionic surfactant and a water-immiscible solvent/diluent, the formulation being adapted to form a slick on a water surface. The formulation is useful in combating pests on or directly beneath water.
Abstract: Compounds of the formula ##STR1## in which R.sub.1 signifies an optionally substituted hydrocarbon radical,R.sub.2 signifies hydrogen, halogen, nitro, a linear or branched optionally substituted alkyl radical such as haloalkyl, an optionally substituted cycloalkyl radical, alkoxy, alkylthio, an optionally substituted aryl radical, an acyl radical of an aliphatic or aromatic sulphonic or carboxylic acid, an ester or amide group of a sulphonic acid, an ester or amide group of a carboxylic acid, an ester group of a carbamic acid, unsubstituted or mono- or disubstituted amino or an acylamino group,The ring A may be further substituted, and may as R.sub.2 bear a condensed cycloalkyl radical, but ring A and any substituent on it is free from carboxylic or sulphonic acid groups and from groups in the ortho-position to the azo group which are capable of the formation of metal complexes,Provided that the total number of carbon atoms in R.sub.
Abstract: This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is alkyl, alkenyl or alkinyl of up to 9 carbon atoms, or 1-ethinylcycloalkyl,R.sub.2 is hydrogen, halogen of atomic number from 17 to 35 or methyl,R.sub.3 is halogen of atomic number from 17 to 35 when R.sub.2 is hydrogen or methyl, and is methyl when R.sub.2 is halogen of atomic number from 17 to 35, andR.sub.4 is hydrogen or a R.sub.5 Co-- group wherein R.sub.5 is alkyl of 1 to 6 carbon atoms, phenoxy-alkyl, phenyl or substituted phenyl,Which are useful, for example, for treating coronary conditions.
Abstract: The present invention concerns a novel process for preparing derivatives useful in the production of prostaglandins.The present invention provides a process for the production of a compound of formula I ##STR1## wherein R.sub.1 is a protecting group which comprises hydrolyzing a compound of formula II ##STR2## wherein R.sub.1 is as defined above and R.sub.2 is a leaving group, under acidic conditions.
Abstract: The present invention relates to a pharmaceutical composition comprising aggregates of diameter of at most 20,000 A, comprising:Component (a) comprising at least one pharmaceutically acceptable active agent, andComponent (b) comprising at least one pharmaceutically acceptable emulsifier,Component (b) having a mean HLB value of 10 to 30 and present in an amount greater than 10 times by weight of component (a).The composition has enhanced resorption properties.
Abstract: The present invention concerns novel 13-bromo-lysergic acid compounds of formula I: ##STR1## wherein R.sub.2 is isopropyl, 1 or 2-methylpropyl or benzyl, useful as agents for the treatment of cerebral insufficiency.
Abstract: Disclosed is a preparation, for use in the production of inks for transfer printing, which preparation comprises, in intimate admixture, a disperse dye and/or dispersion optical brightener, sublimable in the range of from 180.degree. to 220.degree. C, and a dispersing aid being a compound of formula I, ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, independently, are straight or branched chain C.sub.2-8 alkylene radicals, the OH groups being bound other than onto the carbon atoms adjacent the nitrogen atoms,The production and use thereof.