Patents Assigned to SANDOZ
  • Patent number: 4136033
    Abstract: Compounds of the formula ##STR1## wherein K.sup..sym. is a cationic group, preferably heterocyclic,R is hydrogen or an organic radical, preferably alkyl, phenyl or acyl,R.sub.1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, substituted heterocyclyl, amino or substituted amino, andA.sup..crclbar. is an anion,Are useful as intermediates in the synthesis of azo dyes of the formula ##STR2## wherein D is an aromatic carbocyclic or heterocyclic diazo component radical, andK.sup..sym., r, r.sub.1 and A.sup..crclbar. are as defined above.
    Type: Grant
    Filed: June 25, 1974
    Date of Patent: January 23, 1979
    Assignee: Sandoz Ltd.
    Inventor: Willy Steinemann
  • Patent number: 4136114
    Abstract: 2-Aminomethylene-5-hydroxy-N-alkyl-3-oxo-amides.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: January 23, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4136184
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones e.g., 6-(p-chlorophenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-one are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: January 23, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4132725
    Abstract: Benzazasilin-4-ones of the formula ##STR1## where R.sub.1 represents H or alkyl of 1-5 carbon atoms,R.sub.2 represents alkyl of 1-5 carbon atoms,R.sub.3 represents alkyl of 1-5 carbon atoms or ##STR2## where R.sub.5 represents H, alkyl of 1-5 carbon atoms, halo having an atomic weight of about 19-36, alkoxy having 1-5 carbon atoms, or ##STR3## where R.sub.6 and R.sub.7 each, independently, represent alkyl having 1-2 carbon atoms, andR.sub.4 represents alkyl having 1-3 carbon atoms, e.g., 1-(p-chlorophenyl)-2,3-dihydro-1,3-dimethyl-3,1-benzazasilin-4(1H)-one, are prepared from the appropriate lithiated N-alkyl benzamide and a halomethyl halosilane and are useful as antiobesity agents or sleep inducers.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: January 2, 1979
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Patent number: 4131679
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 is straight chain lower alkyl or ##STR2## where R.sub.4 is hydrogen or halo having an atomic weight of about 19 to 36, andR.sub.2 is straight chain lower alkyl, andR.sub.3 is hydrogen or halo as defined above,Which are useful as minor tranquilizers and muscle relaxants.
    Type: Grant
    Filed: July 26, 1977
    Date of Patent: December 26, 1978
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4130589
    Abstract: The present invention concerns novel oxalkylated alkyl polyamines in free base, acid addition salt and/or quaternary ammonium salt form useful as anti-foaming agents.
    Type: Grant
    Filed: February 14, 1978
    Date of Patent: December 19, 1978
    Assignee: Sandoz Ltd.
    Inventors: Guido Grassi, Hans-Peter Baumann, Helmut Pummer
  • Patent number: 4129658
    Abstract: The present invention provides compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, fluorine, chlorine, trifuoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, andR.sub.3 is hydrogen, or alkoxy of 1 to 4 carbon atoms, with the proviso that when R.sub.3 is alkoxy then at least one of R.sub.1 and R.sub.2 is alkoxy, orR.sub.1 and R.sub.2 are bound to adjacent ring carbon atoms and are together --(CH.sub.2).sub.m --, wherein m is 3 or 4, --CH.dbd.CH--CH.dbd.CH--, or --O--CH.sub.2 --X--, wherein X is --O-- or --CH.sub.2 --, andR.sub.3 is hydrogen, fluorine, chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms,Useful as hypolipidemic agents and anti-arrhythmics.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: December 12, 1978
    Assignee: Sandoz Ltd.
    Inventor: Richard Berthold
  • Patent number: 4128544
    Abstract: Complexes of the formula ##STR1## WHEREIN V is hydroxy or amino, one of X.sub.1 and X.sub.2 is sulfo and the other is --NHR.sub.3, wherein R.sub.3 is heterocyclyl containing at least one substituent cleavable as an anion, preferably a halopyrimidyl or halotriazinyl group,Y is methyl, methoxy, ethoxy or methoxyethoxy,Z is hydrogen, methyl or methoxy,M is 0 or 1, andN is 2 or 3,WITH THE PROVISO THAT THE --N.dbd.N-- and --O--Cu--O-- groups are bound to adjacent positions of the naphthalene ring, are useful for the dyeing or printing of natural or regenerated cellulosic fibres. The obtained dyeings and prints possess notable stability in alkaline medium and fastness to light and satisfactory fastness to wet treatments, chlorine and peroxide. The dyes possess notable build-up and fixation.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: December 5, 1978
    Assignee: Sandoz Ltd.
    Inventor: Lukas Schneider
  • Patent number: 4128549
    Abstract: The present invention concerns a novel process for the production of known benzocycloheptathiophene derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen, chlorine, bromine or alkoxy, and R.sub.2 is alkyl. The compounds are useful as specific histaminolytics for use in the treatment of allergic conditions.
    Type: Grant
    Filed: February 3, 1977
    Date of Patent: December 5, 1978
    Assignee: Sandoz Ltd.
    Inventors: Jean-Pierre Bourquin, Gustav Schwarb, Erwin Waldvogel
  • Patent number: 4128649
    Abstract: Anti-allergic 4-hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido[2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with an alkali metal salt of a malonic ester.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: December 5, 1978
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4127567
    Abstract: Compounds of the formula ##STR1## in which A signifies a 1,4- or 1,5-naphthylene radical, unsubstituted or substituted by up to two substituents selected from chlorine, bromine, methyl, nitro, methoxy and cyano,The R.sub.1 's, independently, signify halogen or nitro, andThe R.sub.2 's, R.sub.3 's, R.sub.4 's and R.sub.5 's, independently, signify hydrogen, halogen or lower alkoxycarbonyl, with the proviso thatI. each benzene nucleus bears at least two substituents, andIi. each benzene nucleus bears no more than one alkoxycarbonyl group,Which, alone or in admixture one with another, are useful inter alia for pigmenting plastics in the mass and as pigmenting agents in surface coatings.
    Type: Grant
    Filed: June 29, 1976
    Date of Patent: November 28, 1978
    Assignee: Sandoz Ltd.
    Inventors: Willy Forter, Hans-Rudolf Ott
  • Patent number: 4127658
    Abstract: Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenylyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: November 28, 1978
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4127574
    Abstract: Anti-allergic 4-hydroxy-3-sulfonyl-quinolin-2(1H)-ones are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of sulfonyl acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: November 28, 1978
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Patent number: 4126608
    Abstract: Salts of stilbene-azo and stilbene-azoxy dyestuffs, and mixtures thereof in hich the cations are selected from tetra-alkylammonium, tetraalkylammonium in combination with lithium, sodium, potassium or ammonium, and ammonium in combination with lithium, sodium or potassium, have good cold water solubility relative to known salts of such dyes.The preferred dyes have the formula ##STR1## wherein (1) EACH R' is independently --SO.sub.3.sup..crclbar. M.sup..sym. or --SO.sub.3.sup..crclbar. N.sup..sym. (R).sub.4'wherein each R is independently alkyl of 1 to 6 carbon atoms or alkyl of 1 to 6 carbon atoms substituted by hydroxy, cyano, halo or phenyl, andEach M.sup..sym. is independently hydrogen, lithium, sodium, potassium or ammonium, with the proviso that at least one R' is --SO.sub.3.sup..crclbar. N.sup..sym. (R).sub.4'(2) each R' is --SO.sub.3.sup..crclbar. M.sup..delta.,wherein each M.sup..sym. is lithium, sodium, potassium, or ammonium, with the proviso that at least one M.sup..sym.
    Type: Grant
    Filed: December 17, 1975
    Date of Patent: November 21, 1978
    Assignee: Fidelity Union Trust Company as Executive Trustee under the Sandoz Trust
    Inventor: Reinhard Pedrazzi
  • Patent number: 4125652
    Abstract: Disclosed is a treatment process for textile substrates comprising or consisting of regenerated cellulose, which process comprises applying to the substrate an aqueous medium comprising (A) a monomeric, hydrolysis stable, hydrosoluble, resin forming cross linking agent containing at least two N-methylol or N-alkoxymethyl groups, (B) a hydrosoluble, prepolymerised, linear, filler resin forming, cross-linking agent, also containing at least two N-methylol or N-alkoxymethyl groups, (C) a reactive acetal of formula ##STR1## wherein X and Y, independently, are H or CH.sub.2 OH, (D) a first cross-linking catalyst, being an alkaline earth metal salt of a strong acid and (E) a second cross-linking catalyst, being an acidic aluminium salt, subsequently drying the substrate and subjecting same to a temperature at which cross-linking takes place, and an aqueous concentrate for use therein.
    Type: Grant
    Filed: May 13, 1977
    Date of Patent: November 14, 1978
    Assignee: Sandoz Ltd.
    Inventors: Paul Komminoth, Tibor Robinson, Milica Urosevic
  • Patent number: 4124588
    Abstract: Anti-allergic 4-hydroxy-3-quinoline-2-one-3-phosphonic acid esters are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of phosphono acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: November 7, 1978
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Patent number: 4124587
    Abstract: Anti-allergic 4-hydroxy-3-sulfinyl-quinolin-2(1H)-ones are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of sulfinyl acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: November 7, 1978
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4124719
    Abstract: The invention provides new (3aRS,4SR,7aRS)-4-phenyl-hexahydro-4-indolinol derivatives useful as anti-depressants and anti-arrhythmics.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: November 7, 1978
    Assignee: Sandoz Ltd.
    Inventors: Richard Berthold, Franz Troxler
  • Patent number: 4124714
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.3 is hydrogen or halo having an atomic weight of about 19 to 36, which are useful as minor tranquilizers, sleep inducers, muscle relaxants, neuroleptics and anti-ulcer agents.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: November 7, 1978
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4124712
    Abstract: Compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl,R.sub.3 and R.sub.5 are, independently, hydrogen or methyl,R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.6 and R.sub.7 together form a single bond, orR.sub.6 and R.sub.7 are each hydrogen,R.sub.6 is methoxy, andR.sub.7 is hydrogen,Are useful in the treatment of hypertension, angina pectoris, depressions, neuroses and psychoses.
    Type: Grant
    Filed: August 30, 1977
    Date of Patent: November 7, 1978
    Assignee: Sandoz Ltd.
    Inventors: Peter Stutz, Paul Stadler