Patents Assigned to SANDOZ
  • Patent number: 4046757
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is optionally substituted hydrocarbyl (alkyl or phenyl),R.sub.2 is hydrogen, alkyl or acylamino,R.sub.3 is hydrogen, alkyl, substituted alkyl, alkoxy or substituted alkoxy,Each of R.sub.4 and R.sub.5 is independently hydrogen, alkyl or substituted alkyl,T is halo, nitro, cyano, alkyl, alkoxy, alkylsulfonyl, sulfamoyl or alkylsulfamoyl, andn is 0 to 3. These compounds are suitable for the dyeing and printing of textile materials. The dyeings obtained are extremely fast to thermofixation, sublimation, pleating, gas fumes, cross dyeing, rubbing, dry cleaning, chlorine, and wet treatments, such as water, washing and perspiration. The compounds of this invention and other phenylazo-phenyl compounds with an optionally substituted hydrocarbylsulfonyl group (R.sub.1-- SO.sub.
    Type: Grant
    Filed: September 23, 1969
    Date of Patent: September 6, 1977
    Assignee: Sandoz Ltd.
    Inventors: Jacques Meybeck, Curt Mueller, Fred Mueller
  • Patent number: 4046502
    Abstract: Azo dyes of the formula ##STR1## wherein X represents a direct bond or a divalent radical,Y represents a direct bond, an alkylene radical, --S--, --O--, --NH--CO--NH-- or --CH=CH--,R represents a hydrogen atom or a hydrocarbon radical andK represents a primary, secondary or tertiary amino group or an ammonium, hydrazinium or a cycloimmonium group which are useful for dyeing fibers and textiles of polyacrylonitrile or acrylonitrile copolymers and for the dyeing of paper.
    Type: Grant
    Filed: December 17, 1975
    Date of Patent: September 6, 1977
    Assignee: Sandoz Ltd.
    Inventors: Helmut Moser, Hans VON Tobel
  • Patent number: 4046917
    Abstract: The invention relates to a new use of 2,6-dichlorophenyl-acetylguanidine as an anti-migraine agent.
    Type: Grant
    Filed: April 19, 1976
    Date of Patent: September 6, 1977
    Assignee: Sandoz Ltd.
    Inventor: Gunter Scholtysik
  • Patent number: 4046756
    Abstract: Dyes of the formula ##STR1## wherein each of R.sub.1, R.sub.2 and R.sub.6 is independently alkyl of 1 to 4 carbon atoms,Each of R.sub.3 and R.sub.4 is independently chloro or bromo, andEach of R.sub.5 and R.sub.7 is independently hydrogen or methyl, give dyeings of excellent fastness on textiles of hydrophobic synthetic and regenerated fibers made from high molecular organic materials.
    Type: Grant
    Filed: May 30, 1975
    Date of Patent: September 6, 1977
    Assignee: Sandoz Ltd.
    Inventors: Piero Maderni, Curt Mueller
  • Patent number: 4045561
    Abstract: The present invention concerns novel pyrimidinyl phosphoric and thiophosphoric esters. ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are substituents, e.g. alkyl,R.sub.4 is an amino or heterocyclic function andZ and Y are bridging functions, e.g. oxygen.The compounds are useful insecticides.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: August 30, 1977
    Assignee: Sandoz Ltd.
    Inventors: Herbert Muhle, Karlheinz Milzner, Fritz Reisser
  • Patent number: 4045443
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen or halogen having an atomic number from 9 to 35 in the 10- or 11-position, andR is a radical of the series OR.sub.1, SR.sub.2, NR.sub.3 R.sub.4,wherein R.sub.1 and R.sub.2 are alkyl of 1 to 4 carbon atoms, hydroxyalkyl or aminoalkyl of 2 to 4 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms in the aggregate thereof, andR.sub.3 and R.sub.4 are, independently, hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms in the aggregate thereof,Useful as psycho-stimulants or vigilance increasing agents.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: August 30, 1977
    Assignee: Sandoz Ltd.
    Inventor: Paul Pfaffli
  • Patent number: 4045572
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl,R.sub.3 is hydrogen, lower alkyl, lower hydroxyalkyl, or phenylalkyl of 7 to 10 carbon atoms, wherein the phenyl ring is unsubstituted or mono-substituted, or independently di-substituted, by halogen, lower alkyl, lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino, andR.sub.4 is hydrogen, lower alkyl or lower hydroxyalkyl,Useful as anti-arrhythmics and anti-depressants.
    Type: Grant
    Filed: May 26, 1976
    Date of Patent: August 30, 1977
    Assignee: Sandoz Ltd.
    Inventor: John Bernard Bream
  • Patent number: 4043712
    Abstract: The invention concerns a novel adjustable roller pump assembly of the type comprising a semi-circular plate against the inner surface of which a flexible tube is located and a pair of diametrically arranged cylindrical rollers mounted on a driven rotatable body. The invention is related to a special means for adjusting the distance between the axes of the rollers so that the degree which the rollers compress the flexible tube can be adjusted. This means comprises an adjustment shaft rotatable about an axis transverse of the axis of rotation of the rotatable body and having at its ends cylindrical locating elements eccentric to the axis of rotation of the adjustment shaft, said locating elements acting on arms on which rollers are mounted so that adjustment of the adjustment shaft displaces the arms and hence the rollers.
    Type: Grant
    Filed: December 23, 1975
    Date of Patent: August 23, 1977
    Assignee: Sandoz Ltd.
    Inventor: Graziano Azzolini
  • Patent number: 4042562
    Abstract: The present invention concerns novel nitrogen-containing aromatic heterocyclic compounds of the formula: ##STR1## wherein R is a group of the formula ##STR2## wherein R.sub.1 and R.sub.2 are substituents, e.g. alkyl and R.sub.3 is hydrogen or a substituent, e.g. alkyl; R.sub.4 is a group R.sub.14 --X--, wherein R.sub.14 is a substituent, e.g. alkyl and X is --O--, --S-- or ##STR3## wherein R.sub.6 is hydrogen or a substituent, e.g. alkyl, or R.sub.4 is a heterocyclic ring or has one of the significances of R; R.sub.5 has one of the significances of R.sub.4 ; and Y is --N.dbd. or --CH.dbd..The compounds are useful as anti-oxidants in, e.g. plastics materials.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: August 16, 1977
    Assignee: Sandoz Ltd.
    Inventors: Kurt Hofer, Guenther Tscheulin
  • Patent number: 4042632
    Abstract: New antistatic compounds of formula ##STR1## WHEREIN R.sub.1 is alkyl optionally interrupted by 1 or 2 S, SO or SO.sub.2 moieties or 1 COO moiety, any alkyl(ene) being optionally hydroxyl-substituted; cycloalkyl; alkylcycloalkyl; or a mono- or polyoxyalkylene group terminated by alkyl, optionally alkyl-substituted phenyl or phenylalkyl:,n is 1 or 2;m is an integer 1 to 7;R.sub.2 is (m + 1) valent alkylene optionally interrupted by 1 or 2 O, S, SO or SO.sub.2 moieties; bivalent benzene, cyclohexane, biphenyl, diphenyloxide, -sulphide, -sulphoxide, -sulphone or -methane, 2,2-diphenylpropane, bis-cyclohexylmethane or 2,2-bis-cyclohexylpropane, or a (m + 1) valent mono- or polyoxyalkylene group containing R.sub.2 ;and each R.sub.3, independently, has one of the meanings given for R.sub.1, or is hydrogen or phenyl, naphthyl or phenylalkyl optionally substituted on the aromatic nucleus; a group ##STR2## having the above meanings; or a group ##STR3## in which R.sub.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: August 16, 1977
    Assignee: Sandoz Ltd.
    Inventors: Kurt Hofer, Sr., Kurt Hofer, Jr.
  • Patent number: 4042596
    Abstract: 2-Alkyl-5-phenethyl-4-oxazolecarboxylic acids, esters and carbonyl halides are disclosed, which are useful as intermediates in the preparation of known benzocycloheptaoxazoles.
    Type: Grant
    Filed: September 1, 1976
    Date of Patent: August 16, 1977
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • Patent number: 4042577
    Abstract: Compounds of the formula ##STR1## in which R.sub.1 signifies a group of the formula --NH.sub.2, --NH--R.sub.4 or --O--R.sub.4, in which R.sub.4 signifies a (C.sub.1-8)alkyl radical, a (C.sub.5-8)cycloalkyl radical or an unsubstituted or substituted phenyl, naphthyl or heterocyclic radical,Each of R.sub.2 and R.sub.3, which may be the same or different, signifies a hydrogen atom, a hydroxyl, (C.sub.1-8)alkoxy, amino, (C.sub.5-8)cycloalkylamino, (C.sub.1-8)alkylamino, (C.sub.1:8)dialkylamino, phenyl- or naphthylamino or N-phenyl-N-(C.sub.1-8)alkylamino group,A signifies a nitrogen atom or a group of the formula ##STR2## in which R.sub.6 signifies a hydrogen or halogen atom or a (C.sub.1-8)alkyl radical,Either n is 1 and D signifies the radical of a diazo component,Or n is 2 and D signifies the radical of a tetrazo component,Are useful as coloring materials, especially as pigments for plastics, synthetic resins, varnishes, viscose, cellulose acetate, printing inks and paper stock.
    Type: Grant
    Filed: September 30, 1974
    Date of Patent: August 16, 1977
    Assignee: Sandoz Ltd.
    Inventor: Bansi Lal Kaul
  • Patent number: 4042580
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is chloro, bromo, cyano, nitro, alkylsulfonyl, substituted alkylsulfonyl, phenylsulfonyl or substituted phenylsulfonyl,R.sub.2 is hydrogen, chloro or bromo,R.sub.3 is hydrogen, chloro, bromo or acylamino, with the proviso that at least one of R.sub.2 and R.sub.3 is hydrogen,R.sub.4 is hydrogen, alkyl, substituted alkyl, alkoxy or substituted alkoxy,Each of R.sub.5 and R.sub.6 is independently alkyl or substituted alkyl, wherein each substituent of substituted alkyl is independently chloro, bromo, cyano, hydroxy, alkoxy, chloroalkoxy, bromoalkoxy, cyanoalkoxy, formyloxy, alkylcarbonyloxy, substituted alkylcarbonyloxy, benzoyloxy, substituted benzoyloxy, alkoxycarbonyl, substituted alkoxycarbonyl, phenoxycarbonyl, substituted phenoxycarbonyl, alkoxycarbonyloxy, substituted alkoxycarbonyloxy, phenoxycarbonyloxy or substituted phenoxycarbonyloxy,R.sub.7 is alkyl or substituted alkyl,X is --CO--, --CO.sub.2 -- or --SO.sub.2 --, and n is 2, 3 or 4.
    Type: Grant
    Filed: March 3, 1975
    Date of Patent: August 16, 1977
    Assignee: Sandoz Ltd.
    Inventor: Wolfgang Groebke
  • Patent number: 4042591
    Abstract: Disclosed are compounds of formula I ##STR1## WHERE R.sub.1 is a fused benzene or naphthalene nucleus, m is one or two and R.sub.2 and R.sub.3 have various significances, their production and use as pigments and disperse dyes.
    Type: Grant
    Filed: May 23, 1974
    Date of Patent: August 16, 1977
    Assignee: Sandoz Ltd.
    Inventor: Bansi Lal Kaul
  • Patent number: 4042370
    Abstract: .beta.-Haloethanephosphonates and thio derivatives thereof of formula, ##STR1## where X signifies chlorine or bromine,Y signifies oxygen or sulphur,AndZ signifies a carboxylic acid ester or carbamoyl group, or an optionally further substituted methyl or ethyl group substituted by such a group, or signifies an acylmethyl, optionally aryl-substituted alkenyl or alkynyl, cyclic ether, e.g. tetrahydropyranyl, or optionally mono-substituted cyanomethyl group, or signifies an alkyl-, cycloalkyl- or aryl-thio, -sulphinyl or -sulphonyl group, or an optionally further substituted methyl or ethyl group substituted by such a group, or signifies a sulphonic acid ester group, or an optionally further substituted methyl or ethyl group substituted by such a group,Are useful as regulators of plant growth or plant secretion, especially as stimulators of latex flow in latex-forming plants.
    Type: Grant
    Filed: September 11, 1975
    Date of Patent: August 16, 1977
    Assignee: Sandoz Ltd.
    Inventor: Werner Trueb
  • Patent number: 4042704
    Abstract: The compounds are benz[f]indazoles, e.g., 3-(p-chlorophenyl)-1-methylbenz[f]indazole, and are useful as fertility control agents.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: August 16, 1977
    Assignee: Sandoz, Inc.
    Inventor: Robert V. Coombs
  • Patent number: 4038269
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is chloro, bromo, cyano, nitro, alkylsulphonyl, substituted alkylsulphonyl, phenylsulphonyl or substituted phenylsulphonyl,R.sub.2 is hydrogen, chloro, bromo or cyano,R.sub.3 is hydrogen, chloro, bromo or acylamino, with the proviso that at least one of R.sub.2 and R.sub.3 is hydrogen,R.sub.4 is hydrogen, alkyl, substituted alkyl, alkoxy or substituted alkoxy,R.sub.5 is alkyl or substituted alkyl,R.sub.6 is alkylene or 1 to 4 carbon atoms,R.sub.7 is alkyl of substituted alkyl, andX is --CO--, --CO.sub.2-- or --SO.sub.2 --.These dyes are suitable for application as disperse dyes and as such are employed for dyeing high molecular weight synthetic and regenerated organic fibers in loose form, as yarn and in the various textile forms. The dyes are of high tinctorial strength, have good affinity and are resistant to sublimation; they give dyeings of notably good light and wet fastness.
    Type: Grant
    Filed: January 2, 1976
    Date of Patent: July 26, 1977
    Assignee: Sandoz Ltd.
    Inventor: Wolfgang Groebke
  • Patent number: 4036855
    Abstract: Imidazo isoindoles, e.g. 5-(p-chlorophenyl)-5-hydroxy-2,3-dihydro-5H-imidazo[2,1a]isoindol, may be prepared by treating a corresponding 2-benzoyl benzoic acid with a substituted ethylene diamine, and treating a resulting intermediate first with concentrated acid and then with base. The products are active as anorexic agents.
    Type: Grant
    Filed: October 29, 1975
    Date of Patent: July 19, 1977
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4036980
    Abstract: Benzodioxan derivatives of formula, ##STR1## in which R is a group of formula A ##STR2## or of formula B,--(CH.sub.2).sub.p --CR.sub.6 =CR.sub.5 --(CH.sub.2).sub.n --O--R.sub.2 BwhereinR.sub.2 is a hydrocarbon radical, e.g. alkyl or cycloalkyl,R.sub.3 and R.sub.4, independently, are hydrogen or alkyl,R.sub.5 and R.sub.6, independently, are hydrogen or methyl,m, n and p are integers,R.sub.1 is hydrogen or alkyl,X is oxygen or sulphurAndZ is hydrogen or a substituent, e.g. alkyl, are useful as insect and acarid growth inhibiting agents.
    Type: Grant
    Filed: May 28, 1975
    Date of Patent: July 19, 1977
    Assignee: Sandoz Ltd.
    Inventors: Fritz Schaub, Hanspeter Schelling
  • Patent number: 4036851
    Abstract: 1,3-Diphenyl substituted pyrazolines having, in the 4- or 5-position of the pyrazoline ring, a sulpho group in free acid or salt form, and the use thereof as optical brightening agents, particularly for synthetic polyamide.
    Type: Grant
    Filed: January 23, 1975
    Date of Patent: July 19, 1977
    Assignee: Sandoz Ltd.
    Inventors: Alec Victor Mercer, John Stephen Oakland