Patents Assigned to SANDOZ
  • Patent number: 4112091
    Abstract: Inhibiting methanogenesis by adding polyhaloalkyl or alkenyl alcohol esters of piperazino acids of the formula ##STR1## wherein X and Z are oxygen or sulphur.
    Type: Grant
    Filed: April 4, 1977
    Date of Patent: September 5, 1978
    Assignee: Sandoz Ltd.
    Inventors: Hans Nesvadba, Hellmuth Reinshagen
  • Patent number: 4112111
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 to R.sub.3 are hydrogen or optionally substituted hydrocarbyl substituents, andR.sub.5 and R.sub.6 are hydrogen, halogen, alkoxy or alkylthio,Useful as anti-hypertensive agents.
    Type: Grant
    Filed: July 27, 1977
    Date of Patent: September 5, 1978
    Assignee: Sandoz Ltd.
    Inventors: Gerhard Bormann, Richard Berthold
  • Patent number: 4108887
    Abstract: Disclosed are compounds of formula I ##STR1## in which R.sub.1 and R.sub.4, independently, are hydrogen, a non-chromophoric second order substituent, or alkyl or alkenyl unsubstituted or substituted by a non-chromophoric group,R.sub.2 and R.sub.5, independently, are hydrogen or alkyl or alkenyl, unsubstituted or substituted by a non-chromophoric group,R.sub.3 and R.sub.6, independently, are hydrogen, alkyl, carboxyl or a non-chromophoric esterified carboxyl group, orR.sub.2, together with R.sub.3, and/or R.sub.5 together with R.sub.6, signify an alkylene bridge,R.sub.7 and R.sub.8, independently, signify hydrogen or a non-chromophoric substituent, or, whenR.sub.7 is in the 3-position and/or R.sub.8 in the 3' position, R.sub.7 together with R.sub.2, and/or R.sub.8 together with R.sub.5 signify an alkylene bridge,With the proviso that no more than one of R.sub.1 and R.sub.2 and no more than one of R.sub.4 and R.sub.5 signify hydrogen, their production and use as optical brightening agents.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: August 22, 1978
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Juerg Heller
  • Patent number: 4108812
    Abstract: Disclosed are aqueous printing inks comprising an anionic dyestuff, a cationic fixing agent and ammonia or a volatile amine, and the use thereof in flexographic printing, particularly of tissue papers.
    Type: Grant
    Filed: December 1, 1975
    Date of Patent: August 22, 1978
    Assignee: Sandoz Ltd.
    Inventor: Erwin Grueninger
  • Patent number: 4108985
    Abstract: The present invention provides dihydrocyclosporin C of formula, ##STR1## useful as an immunosuppressive.
    Type: Grant
    Filed: October 27, 1976
    Date of Patent: August 22, 1978
    Assignee: Sandoz Ltd.
    Inventors: Artur Ruegger, Max Kuhn
  • Patent number: 4107311
    Abstract: Substituted spiro[isoindoline-1,3'(4'H)-isoquinoline]-1',3-diones, e.g., 2,2'-dimethyl spiro[isoindoline-1,3'(4'H)-isoquinoline]-1',3-dione, are prepared by cyclizing .alpha.-(1-hydroxy-3-oxoisoindolin-1-yl)-o-toluamides and are useful as non-estrogenic anti-fertility agents.
    Type: Grant
    Filed: July 7, 1976
    Date of Patent: August 15, 1978
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Patent number: 4107434
    Abstract: Novel process for the production of antibacterially active pleuromutilin derivatives.
    Type: Grant
    Filed: January 10, 1977
    Date of Patent: August 15, 1978
    Assignee: Sandoz Ltd.
    Inventor: Erwin Waldvogel
  • Patent number: 4107164
    Abstract: This invention relates to new pleuromutilins of the formula: ##STR1## wherein EITHERR.sub.1 is ethyl or vinyl,N is an integer from 2 to 5,X is sulphur, a group ##STR2## or a group =N--R.sub.4 .sup.I, whereinWhereinEither Y and Z are both sulphur, orOne of Y and Z is oxygen and the other is sulphur, andR.sub.4.sup.i is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above,Each ofR.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members,And pharmaceutically acceptable acid addition salts and quaternary salts thereof.Processes for the preparation of such compounds are described.The compounds are antibiotics with an antibacterial effect.
    Type: Grant
    Filed: January 10, 1977
    Date of Patent: August 15, 1978
    Assignee: Sandoz Ltd.
    Inventors: Helmut Egger, Hellmuth Reinshagen
  • Patent number: 4107138
    Abstract: Organic materials are stabilized against the effects of heat, light or oxygen by addition of a compound of the formula ##STR1## WHEREIN X is --CH.sub.2 --, --O-- or -- S--,Y.sub.1, y.sub.2, y.sub.3 and Y.sub.4 are --O-- or --S--,R.sub.1, r.sub.2, r.sub.3 and R.sub.4 are hydrogen or hydrocarbon radicalsn is 0 or 1And rings A and B may be further substituted by 1 or 2 alkyl groupsOr an inorganic salt of such a compound in which any of R.sub.1 -R.sub.4 are hydrogen.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: August 15, 1978
    Assignee: Sandoz Ltd.
    Inventors: Kurt Hofer, Guenther Tscheulin
  • Patent number: 4104468
    Abstract: The present invention relates to optical brightening agents comprising the basic structure of formula I, ##STR1## The brighteners are useful for optically brightening textile and non-textile substrates, e.g. of natural or regenerated cellulose, natural or synthetic polyamides, modified or non-modified polyolefins, polyurethanes, polyvinyl chloride and polyester.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: August 1, 1978
    Assignee: Sandoz Ltd.
    Inventor: Salvatore Valenti
  • Patent number: 4103014
    Abstract: The present invention relates to the use of the known compound of formula ##STR1## for an agent for inhibiting spermatogenesis in male animals.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: July 25, 1978
    Assignee: Sandoz Ltd.
    Inventor: Christian Hodel
  • Patent number: 4103013
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: July 25, 1978
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4102857
    Abstract: New ultraviolet light-absorbing compounds of the formula ##STR1## IN WHICH R.sub.1 is a substituent, e.g. alkyl,R.sub.2 is a substituent, e.g. alkyl,R.sub.3 is hydrogen or a substituent, e.g. alkyl,N is 1, 2 or 3, andR is an n-valent, optionally substituted benzene radical, or a 1- or 2-valent naphthalene or heterocyclic radical, which are producible by known processes. Such compounds are useful as stabilizers of organic materials, particularly plastics materials, against the degrading action of ultraviolet light and can be either applied as a coating on the organic material, or incorporated therein.Such compounds are useful as stabilizers of organic materials, particularly plastics materials, against the degrading action of ultraviolet light and can be either applied as a coating on the organic material, or incorporated therein.
    Type: Grant
    Filed: August 20, 1976
    Date of Patent: July 25, 1978
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer, Martin Preiswerk
  • Patent number: 4101553
    Abstract: Imidazo[2,1-a]isoquinolines useful as anorexics and antidepressants are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.
    Type: Grant
    Filed: November 4, 1974
    Date of Patent: July 18, 1978
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4101547
    Abstract: 1,4-Diaminoanthraquinone derivatives containing a halopyrimidinyl or haloquinoxaline-6-carbonyl reactive group are useful as reactive dyestuffs for the dyeing or printing of leather and textile materials.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: July 18, 1978
    Assignee: Sandoz Ltd.
    Inventors: Roland Mislin, Wolfgang Schoenauer, Karl Ulrich Steiner
  • Patent number: 4100165
    Abstract: Imidazo[2,1-a]isoquinolines useful as anorexics and anti-depressants, e.g. 5-(2-thienyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol, are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.
    Type: Grant
    Filed: July 22, 1976
    Date of Patent: July 11, 1978
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4100300
    Abstract: Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: July 11, 1978
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4098954
    Abstract: A method for eliminating or preventing the brightening effect on materials, particularly fibrous materials such as textiles and paper, of anionic optical brightening agents involving the use of hydrosoluble acid addition salts or quaternary ammonium salts of compounds containing the group of formula: ##STR1## wherein the benzene radical is linked within the group at its m- or p-positions.
    Type: Grant
    Filed: January 10, 1977
    Date of Patent: July 4, 1978
    Assignee: Sandoz Ltd.
    Inventor: Giuseppe Raspanti
  • Patent number: 4098908
    Abstract: Phenoxyphenyl pyridyl carbinols and ketones, e.g., p-phenoxyphenyl-nicotinyl ketone, are useful as pharmaceutical agents. The ketones are obtainable by oxidation of corresponding phenoxyphenyl pyridyl carbinols.
    Type: Grant
    Filed: June 28, 1976
    Date of Patent: July 4, 1978
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4097476
    Abstract: Disclosed are compounds of the formula, ##STR1## in which X is hydrogen, chlorine, C.sub.1-4 alkyl or alkoxy, --SO.sub.3 M or --CO.sub.2 M,one of the Y's is hydrogen, the other --SO.sub.3 M,A is a mono- or di-sulphonaphthyl radical which is optionally further substituted, or ##STR2## in which R is hydrogen, hydroxy or C.sub.1-4 alkyl or alkoxy, B is a radical or a coupling component (b.sub.1) to (b.sub.10), ##STR3## WHERE R.sub.1 is --NH.sub.2, anilino or toluidino, R.sub.2 is --NH.sub.2 or --OH, andEither R.sub.3 is hydrogen, orWhen R.sub.1 and R.sub.2 both are --NH.sub.2, R.sub.3 is hydrogen, --SO.sub.3 M or C.sub.1-4 alkyl; ##STR4## WHERE R.sub.4 is hydrogen or C.sub.1-4 alkyl; ##STR5## WHERE R.sub.5 is hydrogen or --CO.sub.2 M; ##STR6## WHERE ONE OF THE Y.sub.1 's is hydrogen, the other --SO.sub.3 M; ##STR7## WHERE R.sub.6 is phenyl or C.sub.1-4 alkylphenyl; ##STR8## where R.sub.7 is --OH or --NH.sub.2, R.sub.8 is hydrogen, phenyl or sulphophenyl, andR.sub.9 is C.sub.1-4 alkyl or --CO.sub.
    Type: Grant
    Filed: June 10, 1975
    Date of Patent: June 27, 1978
    Assignee: Sandoz Ltd.
    Inventor: Heinz Wicki