Patents Assigned to SANDOZ
  • Hydroxymethyl-substituted-2(1H)-quinazolinones
    Patent number: 4064246
    Abstract: Hydroxymethyl-substituted-2(1H)-quinazolinones, e.g., 7-hydroxymethyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone, are useful as anti-inflammatory agents.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: December 20, 1977
    Assignee: Sandoz, Inc.
    Inventor: Eugene A. Papp
  • Substituted hydroxy pyridones
    Patent number: 4064251
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R is ##STR2## and R.sub.1 is straight chain lower alkyl, or ##STR3## where R.sub.3 is hydrogen or halo having an atomic weight of about 19 to 36,Which are useful as minor tranquilizers, sleep inducers and muscle relaxants.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: December 20, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Organic compounds
    Patent number: 4064244
    Abstract: The present invention concerns novel 2-(1-piperazinyl)-thiazole derivatives of the formula, ##STR1## wherein R.sub.1 is alkyl or cycloalkly,R.sub.2 is hydrogen or alkyl, andR.sub.3 is benzyl, alkoxyalkyl or alkoxycarbonyl, or alkyl, alkenyl, alkanoyl or hydroxyalkyl, or acyloxyalkyl,Useful as vigilance increasing agents, anorexigenic agents and anti-migraine agents.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: December 20, 1977
    Assignee: Sandoz Ltd.
    Inventor: Dieter Sorg
  • Phosphoric acid derivatives as flameproofing agents
    Patent number: 4062687
    Abstract: Flameproofed cellulose includes as a flameproofing agent a compound selected from esters, ester-amides and amides of pyrophosphoric, of mono-, di- and trithiopyrophosphoric, of triphosphoric, and of mono-, di-, tri- and pentathiotriphosphoric acids. Preferred flameproofed cellulose, and other polymeric organic materials include as a flameproofing agent a compound selected from a smaller class of the above compounds.
    Type: Grant
    Filed: May 26, 1976
    Date of Patent: December 13, 1977
    Assignee: Sandoz Ltd.
    Inventors: Claudine Mauric, Rainer Wolf
  • Apparatus for controlling blood flow
    Patent number: 4061142
    Abstract: This invention provides a single needle dialysis blood tubing occluder, comprising in a preferred aspect, a pair of pivotly mounted clamping arms having a leaf spring affixed to the non-pivot end of each occluder with the spring in slidable engagement with a symmetrical cam. Means are provided for actuating the cam, whereby the cam moves the tubing occluder to alternately occlude and non-occlude a pair of blood tubings.
    Type: Grant
    Filed: June 16, 1976
    Date of Patent: December 6, 1977
    Assignee: Sandoz, Inc.
    Inventor: Glenn L. Tuttle
  • Iminodimethylene di-tert-alkylophenones and phenols
    Patent number: 4061778
    Abstract: Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4",4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with a substituted amine. The phenols are prepared from the corresponding phenones and both the phenones and the phenols are useful as hypolipidemic agents.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: December 6, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • 6-Piperazino-11-methylene-dibenzazepines[b,e]
    Patent number: 4061752
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms,Or hydroxyalkyl of 1 to 4 carbon atoms, andR.sub.2 is hydrogen or halogen,Useful as anti-psychotics and sleep-inducing agents.
    Type: Grant
    Filed: July 30, 1976
    Date of Patent: December 6, 1977
    Assignee: Sandoz Ltd.
    Inventor: Franz Martin Kunzle
  • Enzymatically oxidizing interferon
    Patent number: 4061538
    Abstract: The invention provides structurally modified interferons, processes for producing such and a method of purification of interferons and structurally modified interferons. The modified interferons are useful as anti-viral agents.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: December 6, 1977
    Assignee: Sandoz Ltd.
    Inventors: Friedrich Dorner, Marianne Scriba, Rudolf Weil
  • Pyranone carboxamides
    Patent number: 4060533
    Abstract: Pyranone carboxamides, e.g., 2,6-diphenyl-N-methyl-4-oxo-4H-pyran-3-carboxamide, are prepared by cyclizing and dehydrogenating 2-aminomethylene-5-hydroxy-N-methyl-3-oxo-alkylamides and are useful as anti-allergic agents.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: November 29, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Anthranilic acid amides
    Patent number: 4060638
    Abstract: Derivatives of trifluoromethyl-substituted anthranilic acid amides, e.g., N-methyl-o-amino-.alpha.,.alpha.,.alpha.-trifluoromethyl-p-toluamide, are useful as minor tranquilizers and muscle relaxants.
    Type: Grant
    Filed: May 27, 1975
    Date of Patent: November 29, 1977
    Assignee: Sandoz, Inc.
    Inventor: Paul L. Anderson
  • Aromatic carboxylic acid esters and amides as fixing agents
    Patent number: 4060387
    Abstract: The present invention relates to methods of dyeing and printing of textile materials and specifically to the use of fixing agents in such methods. In particular, the present invention relates to the use of aromatic carboxylic acid esters and amides as fixing agents in the dyeing and printing of textile materials.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: November 29, 1977
    Assignee: Sandoz Ltd.
    Inventors: Hans-Peter Baumann, Hans-Georg Karmann
  • Polychlorohydrin ethers of tris-(hydroxymethyl)-aminomethane
    Patent number: 4059631
    Abstract: The present invention concerns a novel method of antistatically treating synthetic, semi-synthetic or natural porous material, particularly fibrous material, which comprises applying thereto a polychlorohydrin ether of tris-(hydroxymethyl)-aminomethane and a polyglycol bis-epichlorohydrin in admixture and/or in partially condensed form, and curing the compound(s) on the material.
    Type: Grant
    Filed: July 9, 1976
    Date of Patent: November 22, 1977
    Assignee: Sandoz Ltd.
    Inventor: Richard Hochreuter
  • Asymmetric 1:2 chromium complexes of monoazo compounds having 1-aryl-3-methyl-pyrazolone-5 coupling components
    Patent number: 4058514
    Abstract: Asymmetric 1:2 chromium complexes of the formula ##STR1## in which R.sub.1 signifies a hydrogen or halogen atom or a nitro group,R.sub.2 signifies a hydrogen or halogen atom, a nitro or sulpho group,R.sub.3 signifies a hydrogen or halogen atom, or a lower alkyl radical,R.sub.4 signifies a hydrogen or halogen atom, a lower alkyl radical or a sulpho group,Each of R.sub.5, R.sub.6 and R.sub.7, independently, signifies a hydrogen or halogen atom or a lower alkyl radical,R signifies a hydrogen atom or a lower alkyl radical, andM.sup.+ signifies a cation,With the provisosI. the radicals R.sub.1 and R.sub.2 occupy the 4- and 6-positions,Ii. where R.sub.4 signifies a sulpho group one of the radicals R.sub.1 and R.sub.2 signifies a halogen atom or a nitro group in the 4-position, andIii.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: November 15, 1977
    Assignee: Sandoz Ltd.
    Inventor: Hanspeter Uehlinger
  • Sulfo group-containing azo compounds having a tetrazo component radical derived from an optionally substituted 3,8-diaminodibenzofuran
    Patent number: 4058516
    Abstract: Dyes of the formula ##STR1## AND SUBSTITUTED DERIVATIVES THEREOF, WHEREIN R is a coupling component radical,R.sub.1 is a coupling component radical, with the proviso that R and R.sub.1 are different, andN is 1 to 8,Are disclosed. They are useful for dyeing and printing natural and synthetic polyamides, cotton and other cellulosic fibers, polypropylene fibers modified by basic groups, synthetic polyamides and polyesters modified by acid groups, paper and leather. They exhibit good fastness to light, wet treatments and abrasion.
    Type: Grant
    Filed: June 20, 1974
    Date of Patent: November 15, 1977
    Assignee: Sandoz Ltd.
    Inventors: Roland Mislin, Hanspeter Uehlinger
  • Certain 5-nitrothiazolylimidazolidine compounds
    Patent number: 4057557
    Abstract: The invention provides novel 5-nitrothiazolylimidazoline derivatives, useful as chemotherapeutic agents.
    Type: Grant
    Filed: February 6, 1976
    Date of Patent: November 8, 1977
    Assignee: Sandoz Ltd.
    Inventors: Gerd Ascher, Hellmuth Reinshagen
  • Substituted or unsubstituted p-alkanoyl toluenes as male anti-fertility agents
    Patent number: 4057646
    Abstract: Certain substituted or unsubstituted p-alkanoyl toluenes, e.g., p-alkanoyl toluene, are useful as male anti-fertility agents.
    Type: Grant
    Filed: August 25, 1976
    Date of Patent: November 8, 1977
    Assignee: Sandoz, Inc.
    Inventors: Francis E. Harrington, Robert S. Ho
  • 1,2,2A,3,4,5 Hexahydrobenz[c,d]indol-1-yl-2-guanidines
    Patent number: 4057560
    Abstract: The present invention concerns novel compounds of formula I, ##STR1## wherein R.sub.1 is hydroxy, or ##STR2## wherein N IS AN INTEGER FROM 1 TO 5, ANDR.sub.3 and R.sub.4 are independently alkyl of 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together form an alkylene chain of 2 or 3 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, phenylalkyl of 7 to 9 carbon atoms, or phenylalkyl of 7 to 9 carbon atoms mono- or disubstituted on the phenyl radical by halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, andEitherX is hydrogen, andY is methyl,OrX is methylthio or dialkylamino, wherein the alkyl chains are independently of 1 to 4 carbon atoms, andY is hydrogen,OrX is chlorine or bromine, andY is chlorine,Or, when R.sub.1 is the above acetal group, X also signifies hydrogen, chlorine, bromine or methyl, and Y signifies hydrogen,Useful as salidiuretics.
    Type: Grant
    Filed: July 10, 1974
    Date of Patent: November 8, 1977
    Assignee: Sandoz Ltd.
    Inventors: Gerhard Bormann, Franz Troxler
  • Furo(3,4-E)-as-triazines and corresponding 4-oxides as sleep inducers and minor tranquilizers
    Patent number: 4055643
    Abstract: 5,5,7,7-tetramethyl-3-substituted or unsubstituted-phenylfuro[3,4-e]-as-triazines and corresponding 4-oxides, e.g., 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine and 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine-4-oxide, are prepared from 2,2,5,5-tetramethyl-3,4(2H,5H)-furandione-3-hydrazone-4-oximes and are useful as sleep inducers and minor tranquilizers.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: October 25, 1977
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
    Patent number: 4055644
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazobicyclo-ene-ones, e.g., 6-(p-chlorophenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-one are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: October 25, 1977
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Imidazolyl-2-quinazoline derivatives
    Patent number: 4055642
    Abstract: Basically substituted imidazolyl-2-quinazolines of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl or halogen;R.sub.2 is lower alkyl, lower alkenyl or lower hydroxalkyl; andR.sub.3 is a basic organic substituent,Are useful as anti-parasitic agents and as mycoplasma growth inhibiting agents.
    Type: Grant
    Filed: May 5, 1976
    Date of Patent: October 25, 1977
    Assignee: Sandoz Ltd.
    Inventors: Hans Nesvadba, Hellmuth Reinshagen