Abstract: Metal complex polyazo dyes having, as a coupling component radical, the radical of a coupling component K, being the product of the condensation, under acidic conditions, of the formaldehyde with a compound or mixture of compounds of formula (a), ##STR1## AND/OR A COMPOUND OR MIXTURE OF COMPOUNDS OF FORMULA (B), ##STR2## WHEREIN EACH R.sub.1 , R.sub.2, R.sub.3 and R.sub.4 is independently is hydrogen, halogen, hydroxy or optionally substituted alkyl or alkoxy, andM is hydrogen or a non-chromophoric cation,The mol ratio of formaldehyde to the other compound(s) (a) and/or (b) being at least 0.6:1 and at least 50 mol % of the other compound(s) (a) and/or (b) containing a --COOM group, and, as diazo or bisdiazo component radical, a radical D- or -D- where D contains at least one metallized azo group, their production and their use for the dyeing of anionic dyeable substrates, particularly leather. The dyes have good levelling capacity and the obtained dyeings possess notable fastness to light.

Abstract: The present invention provides a compound of the formula ##STR1## which possesses pharmacological activity, for example anti-psychotic activity.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen or halogen having an atomic number from 9 to 35 in the 10- or 11-position, andR is a radical of the series OR.sub.1, SR.sub.2, NR.sub.3 R.sub.4,whereinR.sub.1 and R.sub.2 are alkyl of 1 to 4 carbon atoms, hydroxyalkyl or aminoalkyl of 2 to 4 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms in the aggregate thereof, andR.sub.3 and R.sub.4 are, independently, hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms in the aggregate thereof.Useful as psycho-stimulants or vigilance increasing agents.

Abstract: .alpha.-Adrenoceptor agonists are useful in the treatment of acromegaly.

Abstract: A ventilator monitoring system wherein the ventilator is in simultaneous fluid communication with a patient circuit and an exhaust circuit. The patient circuit comprises an inspiratory branch and an expiratory branch. A first one-way valve in the patient circuit inspiratory branch permits ingress only of a gas to the patient circuit. A second one-way valve in the patient circuit expiration branch permits egress only of patient exhaust gas to an expiration valve in the exhaust circuit. A monitor in the patient circuit expiration branch, monitors only the gas actually expired by the patient and not a combination of patient expired gas and excess gas from the ventilator.

Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-N-methyliminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone , are prepared by reacting a corresponding substituted hydroxy pyridone carbonyl with an alkyl amine, and are useful as minor tranquilizers, sleep inducers, muscle relaxants, and neuroleptics.

Abstract: The present invention relates to a new use of an active agent selected from compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 5 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 5 carbon atoms or benzyl, andR.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,In the treatment of oligosphermia and asthenospermia.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein X is H-Ala, D-Ala, .beta.-Ala, propionyl or Ac-Ala (wherein Ac is pharmaceutically acceptable acyl),Y is hydrogen or a direct bond between the sulphur atoms in positions 3 and 14, andZ is the radical --COOH, --COOR.sub.1 (wherein R.sub.1 is lower alkyl), ##STR2## (wherein R.sub.2 and R.sub.3 independently are hydrogen or lower alkyl) or --CH.sub.2 OH,with the proviso that X is other than H-Ala, when Z is COOH.useful as agents for the treatment of Diabetes Mellitus, acromegaly and angiopathy.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 5 carbon atoms,R.sub.2 is a group ##STR2## wherein N IS A WHOLE NUMBER FROM 0 TO 3,R.sub.5 and R.sub.6, independently, are hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35, or together are 3,4-methylenedioxy,R.sub.7 is hydrogen, or when both R.sub.5 and R.sub.6 are alkoxy of 1 to 4 carbon atoms also may be alkoxy of 1 to 4 carbon atoms,R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halogen of atomic number from 9 to 35, andR.sub.4 is hydrogen or alkoxy of 1 to 4 carbon atoms,Useful as sleep-promoting agents, and anti-aggressive agents.

Abstract: Compounds of the formula ##STR1## in which R.sub.1 is hydrogen or nitro,Each of R.sub.2 and R.sub.3, independently, is --OH or --NH.sub.2,R.sub.4 is hydrogen, nitro or (C.sub.1-4) alkyl,R.sub.5 is hydrogen, nitro or (C.sub.1-4) alkoxy,R.sub.6 is hydrogen, (C.sub.1-4) alkyl, (C.sub.1-4) alkoxy, --COOM or --SO.sub.3 M,R.sub.7 is hydrogen or --SO.sub.3 M,R.sub.8 is hydrogen or the radical of a diazo component, andM is a hydrogen ion or a non-chromophoric cation,And mixtures thereof, in metallized form or unmetallized form, which compounds in metallized form are useful as dyes for paper and leather. The dyeings exhibit notable fastness to light, hard water, washing, perspiration, alkali, acid and buffing.

Abstract: Disclosed are compounds which are unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids, e.g., 1-allyl-6,7-dimethoxy-4-hydroxy-2-quinolinone-3-carboxylic acid allyl ester, useful as anti-allergic agents, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic acid unsaturated ester.

Abstract: 2-Amino-3-pyridyl (or phenyl) nitromethylketones are prepared eg by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido [2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with the carbanion resulting from the reaction of nitromethane with a porton abstracting agent. The compounds are useful as anti-allergic agents.

Abstract: This invention provides new antibiotics produced by cultivating a strain of the fungus species, Cylindrocarpon lucidum Booth or Tolypocladium inflatum Gams in contact with a nutrient medium, the antibiotics being useful anti-inflammatory and immunosuppressive agents.

Abstract: The invention provides novel polyglycol ethers of formula I,r--c.sub.2 h.sub.4 o).sub.x --C.sub.3 H.sub.6 O.sub.y --C.sub.2 H.sub.4 O).sub.z --H-- Iin which R is alkoxy of 8 to 24 carbon atoms,X has a value of 9 to 10Y has a value of 12 to 17AndZ has a value of 8 to 12.The new compounds have a number of uses in the dyeing and printing industries, for example as scouring and washing agents.

Abstract: An improved process for the preparation of substituted isoxazolo[4,5-c]pyridin-4(5H)-ones which are either useful as intermediates in the preparation of compounds having pharmaceutical activity or as hypolipidemic agents which comprises cyclizing a corresponding 5-(2-amino-2-phenyl- or substituted phenyl-ethenyl)-3-substituted-N-alkyl isoxazole-4-carboxamide under acidic conditions.

Abstract: Sparingly water-soluble azo compounds of the formula ##STR1## wherein D is phenyl, substituted phenyl, thiazolyl, substituted thiazolyl, benzothiazolyl, substituted benzothiazolyl, 1,3,5-thiadiazolyl, phenyl-1,3,4-thiadiazolyl, nitrobenzoisothiazolyl or substituted thienyl,Wherein each substituent of substituted phenyl, substituted thiazolyl and substituted benzothiazolyl is independently chloro, bromo, nitro, cyano or methylsulfonyl and each substituent of substituted thienyl is independently nitro or acetyl,R.sub.1 is hydrogen, alkyl, alkoxy or --NH--Y--R.sub.5, wherein Y is --CO--, --COO-- or --SO.sub.2 --, and R.sub.5 is alkyl, haloalkyl, phenyl or substituted phenyl,R.sub.2 is hydrogen or alkoxy,R.sub.3 is phenoxyalkyl, substituted phenoxyalkyl, benzyloxyalkyl or substituted benzyloxyalkyl, andR.sub.4 is hydrogen, cyclohexyl, alkyl or alkyl substituted by chloro, bromo or --O--CO--NH--R.sub.6, wherein R.sub.6 is alkyl or phenyl are eminently suitable for application as disperse dyes.

Abstract: Alpha-cyano-o-anisidino derivatives, e.g., alpha-cyano-o-acetanisidide, are useful as hypolipidemic agents. The compounds are obtainable by reacting an appropriate 2-amidophenol with a haloalkylnitrile.

Abstract: This disclosure describes compounds of the formula ##STR1## where R.sub.1 is straight chain alkyl, andR.sub.2 is hydrogen, halo having an atomic weight of about 19 to 36, lower alkoxy or trifluoromethyl,Which are useful as minor tranquilizers and sleep inducers.