Patents Assigned to SANDOZ
  • Patent number: 4036978
    Abstract: Substituted and unsubstituted ethanodibenzoindoles, for example, 3-chloro-1-methyl-1,2-dihydro-6,10b-ethanodibenzo[cd,g] indole, are prepared by cyclizing and reducing N-naphthylbenzamides and are useful as anti-inflammatory agents.
    Type: Grant
    Filed: May 6, 1976
    Date of Patent: July 19, 1977
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4036812
    Abstract: The present invention concerns novel nickel complexes (I) possessing U.V. stabilizing properties characterized by bearing per molecule 2 monodentate nickel coordinated 1,3-hydrocarbyl-4-(greater than C.sub.1)-acyl-pyrazole-5-oxy ligands and one bidentate or two monodentate nickel coordinated primary or secondary amine ligands, and their use as U.V. stabilizers for e.g. plastics materials.
    Type: Grant
    Filed: December 17, 1975
    Date of Patent: July 19, 1977
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer
  • Patent number: 4036976
    Abstract: The present invention relates to indazole derivatives of formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms,R.sub.2 is hydrogen, halogen, hydroxy, or alkyl, alkoxy or alkylthio of 1 to 3 carbon atoms, andR.sub.3 is hydrogen, halogen, alkyl or alkoxy of 1 to 3 carbon atoms, or hydroxy, andA is dimethylene or trimethylene, wherein one hydrogen atom may be replaced by hydroxyl or alkyl of 1 to 3 carbon atomsUseful as anti hypertensive agents.
    Type: Grant
    Filed: September 29, 1975
    Date of Patent: July 19, 1977
    Assignee: Sandoz, Inc.
    Inventor: Peter Neumann
  • Patent number: 4035406
    Abstract: The compounds are 4-naphthyl-4-lower alkyl substituted-2-oxygenated-2-butenes, or butanes; the naphthyl position may be unsubstituted or 6-substituted, e.g., 2-(6-methoxynaphthyl)-2-penten-4-ol, and are useful as pharmaceuticals.
    Type: Grant
    Filed: October 29, 1975
    Date of Patent: July 12, 1977
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Darryl A. Brittain
  • Patent number: 4035508
    Abstract: Bis-substituted benzyl methanamines, e.g. 1-bis(p-pivaloylbenzyl)methanamine are prepared by hydrolyzing a corresponding N-[bis(p-pivaloylbenzyl)methyl]carbamic acid, alkyl ester and are useful as hypolipidemic agents.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: July 12, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4035494
    Abstract: Bis-p-pivaloyl benzylamines, e.g. 4',4'"-[(N,N'-dimethyl-1,2-ethanediyldiimino)dimethylene]bis(pivalophenone ) are prepared by treating a sym-dimethylethylenediamine with a corresponding .alpha.-halo-p-pivaloyl toluene and are useful as hypolipidemic agents.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: July 12, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4035427
    Abstract: Substituted and unsubstituted .alpha.-t-butyl-p-xylene-.alpha.,.alpha.'-diols, e.g., .alpha.-t-butyl-p-xylene-.alpha.,.alpha.'-diol, are prepared from the corresponding 4-pivaloyl-benzyl alcohols and are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: July 12, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4035448
    Abstract: The present invention relates to phosphorus containing compounds and more specifically to phosphorous and phosphoric acid esters of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or alkyl,n is an integer 1 or 2, andY is a mono or divalent aromatic radical.The compounds are useful as flame retardants for, e.g., plastics materials.
    Type: Grant
    Filed: April 7, 1975
    Date of Patent: July 12, 1977
    Assignee: Sandoz Ltd.
    Inventors: Horst Mayerhoefer, Wolfgang Mueller, Urs Sollberger, Rainer Wolf
  • Patent number: 4035501
    Abstract: The present invention concerns heterocyclic compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen or alkyl. R.sub.2 is hydrogen or alkyl and R.sub.3 is substituted or unsubstituted 3-pyridyl, which compounds are useful as salidiuretics and agents for migraine treatment.
    Type: Grant
    Filed: June 23, 1975
    Date of Patent: July 12, 1977
    Assignee: Sandoz Ltd.
    Inventor: Hartmut Hauth
  • Patent number: 4035367
    Abstract: Disclosed are compounds of the class of quinolines substituted at the 2-, 3- or 4-position by an amino function bearing a hydroxyalkyl nitrate moiety, e.g. 4-(2-hydroxyethylpiperazino)-quinoline nitrate. The compounds have various pharmacological activities in animals and are useful, for example, as hypotensive and anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as hypotensive and anti-anginal agents.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: July 12, 1977
    Assignee: Sandoz, Inc.
    Inventor: William R. Simpson
  • Patent number: 4034095
    Abstract: Novel benzo[5,6]cyclohepta[1,2-c]pyridines useful as anti-depressant and anti-cholinergic agents.
    Type: Grant
    Filed: September 9, 1976
    Date of Patent: July 5, 1977
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Patent number: 4033963
    Abstract: The present invention relates to naphthoquinone derivatives of formula I, ##STR1## in which R.sub.1 signifies a halogen atom, a nitro group or an unsubstituted or substituted alkoxy or amino group,R.sub.2 signifies the atoms necessary to form an unsaturated ring system, which ring system has 1 or 2 nuclei and is unsubstituted or substituted,R.sub.3 signifies an unsubstituted or substituted 5-triazinyl or pyrimidyl radical, andn is 0, 1 or 2,Which compounds are free from sulphonic acid groups are useful as pigments or disperse dyes.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: July 5, 1977
    Assignee: Sandoz Ltd.
    Inventor: Bansi Lal Kaul
  • Patent number: 4033957
    Abstract: Triazine derivatives of formula ##STR1## in which R.sub.1 is a tertiary alkyl radical,R.sub.2 is hydrogen or a substituent, e.g. alkyl,n is 0 or an integer,R.sub.3 is --NH-- or --O--CH.sub.3 --.sub.mWherein m is an integer,X is --O--, --S-- or --NR.sub.6 --,wherein R.sub.6 is hydrogen or a substituent, e.g. alkyl or phenyl,R.sub.4 is one of the radicals signified by R.sub.6, or, when X is --NH--, a radical of formula ##STR2## R.sub.1, R.sub.2, n and R.sub.3 being as indicated above, OR R.sub.4, R.sub.6 and the common nitrogen atom, and optionally a further hetero atom, form a saturated 5- or 6-membered heterocyclic ring,And R.sub.5 is one of the radicals signified by --X--R.sub.4, or a substituent, e.g. alkyl,Are useful for stabilizing organic materials, e.g. polypropylene, against the degradative effects of oxygen, heat and/or light.
    Type: Grant
    Filed: December 3, 1974
    Date of Patent: July 5, 1977
    Assignee: Sandoz Ltd.
    Inventors: Kurt Hofer, Guenther Tscheulin
  • Patent number: 4034045
    Abstract: 2,4-Disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrenes e.g., 2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene are useful as hypolipidemic agents.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: July 5, 1977
    Assignee: Sandoz, Inc.
    Inventors: Sandor Barcza, James B. Hendrickson
  • Patent number: 4032530
    Abstract: This invention relates to new pleuromutilins of the formula: ##STR1## wherein EITHER R.sub.1 is ethyl or vinyl,n is an integer from 2 to 5,X is sulphur,A group ##STR2## or a group =N-R.sub.4.sup.I, whereinEither Y and Z are both sulphur, orOne of Y and Z is oxygen and the other is sulphur, andR.sub.4.sup.i is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above, EACH OFR.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members containing one nitrogen atom or one nitrogen atom and a further hetero member selected from sulphur, oxygen and a group =N-R.sub.5.sup.I,wherein R.sub.5.sup.I is alkyl of 1 to 5 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a piperazinyl radical, the second nitrogen atom of which is substituted by a radical R.sub.5.sup.II,whereby R.sub.5.sup.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: June 28, 1977
    Assignee: Sandoz Ltd.
    Inventors: Helmut Egger, Hellmuth Reinshagen
  • Patent number: 4032640
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, halogen of atomic number from 9 to 35, or alkyl or alkoxy of 1 to 4 carbon atoms,R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.3 is hydrogen, chlorine, or alkyl of 1 to 4 carbon atoms,Either A and B are each hydrogen or together a single bond, andn is a whole number from 3 to 7, useful as salidiuretics.
    Type: Grant
    Filed: June 9, 1976
    Date of Patent: June 28, 1977
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Patent number: 4032580
    Abstract: Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: June 28, 1977
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4032558
    Abstract: Stilbene derivatives having at least one further phenyl substituent in the para-position to a benzene ring in the stilbene are optical brighteners particularly suitable for incorporation on spinning masses.
    Type: Grant
    Filed: July 16, 1975
    Date of Patent: June 28, 1977
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Hans Kittl, Salvatore Valenti
  • Patent number: 4032528
    Abstract: Disclosed are compounds which are 1-alkyl-4-alkoxyquinolin-2(1H)-ones, e.g., 1-methyl-4-butoxyquinolin-2(1H)-one, and which are useful as CNS depressant agents. The compounds may be prepared, for example, by reacting a 1-alkyl-4-hydroxyquinolin-2(1H)-one with an alkyl halide in presence of base.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: June 28, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4032637
    Abstract: The present invention concerns a novel therapeutic use as a sleep-promoting agent for the known pharmaceutical compound 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulphinylphenothiazine of the formula: ##STR1##
    Type: Grant
    Filed: October 31, 1974
    Date of Patent: June 28, 1977
    Assignees: Sandoz Ltd., Sandoz, Inc.
    Inventors: Rene Spiegel, John H. Gogerty, Dieter M. Loew, Phillip L. Eden