Patents Assigned to SANDOZ
  • Patent number: 4032644
    Abstract: Substituted or unsubstituted isoxazolyl benzoic acids, e.g. o-(4-methyl-3-phenylisoxazol-5-yl)benzoic acid, are prepared by dehydrating a corresponding 5-hydroxy-2-isoxazolin-5-yl benzoic acid, and are useful as hypolipidemic agents.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: June 28, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4032532
    Abstract: Dyes of the formula ##STR1## wherein R.sub.1 is hydrogen or cyano,R.sub.2 is alkyl, aryl or heterocyclyl, or a substituted derivative thereof,R.sub.20 is hydrocarbyl, heterocyclyl or amino, or a substituted derivative thereof preferably containing a protonizable nitrogen atom, andD is aromatic carbocyclyl or heterocyclyl, or a substituted derivative thereof, with the proviso that it is free of cationic groups,With the proviso that the molecule contains at least one protonizable nitrogen atom. These dyes are eminently suitable for the dyeing and printing of textiles which consist of or contain fibers of polyacrylonitrile or copolymers of acrylonitrile. The dyes are produced by diazotizing an amine of the formula D-NH.sub.
    Type: Grant
    Filed: March 1, 9173
    Date of Patent: June 28, 1977
    Assignee: Sandoz Ltd.
    Inventors: Hermann Burkhard, Roland Entschel, Willy Steinemann
  • Patent number: 4031227
    Abstract: The invention discloses substituted 2H,3H-2,1-benzisothiazole-S-oxides having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by reacting a substituted 2H,3H-2,1-benzisothiazole with an oxidizing agent. The substituted 2H,3H-2,1-benzisothiazole may be prepared by reacting a substituted .alpha.-methylthio-o-toluidine with one equivalent of an oxidizing agent, followed by treatment with base.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: June 21, 1977
    Assignee: Sandoz, Inc.
    Inventor: Thomas E. Jackson
  • Patent number: 4031233
    Abstract: Imidazolyl-phenoxyphenyl-carbinols and ketones, e.g., .alpha.-(p-phenoxyphenyl)-1-methyl-2-imidazolylmethanol and p-phenoxyphenyl 1-methyl-2-imidazolyl ketone, are useful as hypolipidemic agents. The ketones are obtainable by oxidation of corresponding imidazolyl-phenoxyphenyl-carbinols.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: June 21, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4031225
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein N IS A WHOLE NUMBER FROM 1 TO 3,R.sub.1 is hydrogen, or halogen of atomic number from 9 to 35,Each of the two radicals R.sub.2 are the same, and each is hydrogen or alkyl of 1 to 4 carbon atoms,Each of the two radicals R.sub.3 are the same, and each is hydrogen or alkyl of 1 to 4 carbon atoms, andX is carbonyl or methylene,Useful as anti-arrhythmics.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: June 21, 1977
    Assignee: Sandoz Ltd.
    Inventors: Jean-Michel Bastian, Richard Berthold
  • Patent number: 4029684
    Abstract: The present invention concerns novel 2-hydroxybenzophenone derivatives and metal complexes thereof of the formula: ##STR1## wherein Z.sub.1, Z.sub.2, Y.sub.1 and Y.sub.2 are each, independently, hydrogen or a substituent, at least one of Y.sub.1 and Y.sub.2 being a group ##STR2## wherein, R.sub.1 is alkyl R.sub.2 is hydrogen or a substituent andA is oxygen, sulphur or ##STR3## The compounds are useful for stabilizing organic material, e.g. plastics, against degradation under the influence of U.V. radiation.
    Type: Grant
    Filed: May 16, 1975
    Date of Patent: June 14, 1977
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer
  • Patent number: 4026914
    Abstract: Disclosed are compounds of formula I, ##STR1## in which R.sub.1 is C.sub.2-8 alkylene or C.sub.5-8 cycloalkylene,R.sub.2 is C.sub.5-8 cycloalkyl, unsubstituted or substituted by up to 3 methyl groups; or C.sub.1-8 alkyl, unsubstituted or substituted by a C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylcarbonyloxy, C.sub.1-4 alkoxycarbonyloxy or C.sub.1-4 alkoxycarbonyl,Either R.sub.3 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.1-4 alkoxycarbonyl,And R.sub.4 is halogen, cyano, trifluoromethyl, C.sub.5-8 cycloalkyl, C.sub.1-4 alkoxy, C.sub.5-8 cycloalkoxy, C.sub.1-4 alkylthio, C.sub.5-8 cycloalkylthio, phenyl, phenoxy, phenylthio, phenylthio-C.sub.1-4 alkyl, phenyl-C.sub.1-4 alkyl, phenoxy-C.sub.1-4 alkyl, phenylazo, C.sub.1-4 alkoxycarbonyl, C.sub.5-8 -cycloalkoxycarbonyl, phenoxycarbonyl, benzoyl, benzoyloxy, phenoxycarbonyloxy, phenylsulphonyloxy or phenyl-C.sub.1-4 alkylthio,Or R.sub.3 and R.sub.
    Type: Grant
    Filed: September 29, 1975
    Date of Patent: May 31, 1977
    Assignee: Sandoz Ltd.
    Inventor: Ulrich Zirngibl
  • Patent number: 4025641
    Abstract: The present invention concerns novel aromatic long chain alkyl ethers and thioethers of the formula, ##STR1## wherein R.sub.1 is a hydrocarbon group,R.sub.2, r.sub.3, r.sub.4 and R.sub.5, are each hydrogen or alkyl,w and z are integers,X is an ether or thioether bridge, andR.sub.6 is an aromatic radical.The compounds are useful as insecticides and acaricides.
    Type: Grant
    Filed: May 5, 1975
    Date of Patent: May 24, 1977
    Assignee: Sandoz Ltd.
    Inventors: Fritz Schaub, Hans-Peter Schelling
  • Patent number: 4025331
    Abstract: The present invention concerns novel phosphonomethyl glycine derivatives of the formula ##STR1## wherein R is hydrogen, unsubstituted or substituted hydrocarbon or a cation andM is hydrogen or a cation,Possessing herbicidal and plant growth regulating properties.
    Type: Grant
    Filed: October 28, 1975
    Date of Patent: May 24, 1977
    Assignee: Sandoz Ltd.
    Inventor: Jean-Pierre Leber
  • Patent number: 4025507
    Abstract: Disclosed are compounds of formula I, ##STR1## in which THE R.sub.1 's are the same and signify hydrogen or methyl,The R.sub.2 's are the same and signify hydrogen; C.sub.1-6 alkyl; cyclohexyl, unsubstituted or substituted by up to three C.sub.1-6 alkyl radicals; or benzyl, unsubstituted or substituted by up to two substituents selected from halogen, C.sub.1-6 alkoxy and C.sub.1-6 alkyl, andThe M's signify hydrogen or a nonchromophoric cation,Their production and use as optical brightening agents for cellulosic substrates, particularly paper substrates.
    Type: Grant
    Filed: June 25, 1974
    Date of Patent: May 24, 1977
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Hans-Rudolf Schmid
  • Patent number: 4025515
    Abstract: The invention concerns pyrimidine derivatives of the formula: ##STR1## in which X is hydrogen or chlorine and R is alkyl or cycloalkyl, in free base or agriculturally acceptable acid addition salt form.The compounds possess herbicidal activity.
    Type: Grant
    Filed: March 7, 1975
    Date of Patent: May 24, 1977
    Assignee: Sandoz Ltd.
    Inventor: Rupert Schneider
  • Patent number: 4025511
    Abstract: The compounds of this invention are N-alkylcarbonyloxyalkyl substituted isatoic and 3-azaisatoic anhydrides useful as intermediate for pharmacologically active compounds which are prepared by reaction of such an ahydride with a cyclic pseudothiourea.
    Type: Grant
    Filed: December 24, 1974
    Date of Patent: May 24, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4024265
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, alkyl or 1 to 4 carbon atoms, fluorine, chlorine or bromine,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, cycloalkylalkyl of 4 to 10 carbon atoms, alkenyl or alkinyl of 3 to 6 carbon atoms, the multiple bond thereof being other than adjacent to the nitrogen atom of the tricyclic ring system, oxoalkyl of 2 to 5 carbon atoms, the oxygen atom thereof being separated by at least two carbon atoms from the nitrogen atom of the tricyclic ring system, or phenylalkyl of 7 to 10 carbon atoms,R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,And R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms,Useful as antidepressants.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: May 17, 1977
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Patent number: 4024266
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, halogen of an atomic number of from 9 to 35, or alkyl of 1 to 4 carbon atoms,R.sub.2 is alkyl of 1 to 4 carbon atoms,R.sub.4 is alkyl of 1 to 4 carbon atoms, and eitherI.R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms, andA and B together form a bond, orIi.R.sub.3 is hydrogen, andA and B are both hydrogen,Useful as LH inhibitors and antidepressants.
    Type: Grant
    Filed: February 20, 1976
    Date of Patent: May 17, 1977
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Patent number: 4023924
    Abstract: Concentrated, liquid preparations of metal-free direct azo dyes which contain in each instance 1 part by weight of dye, 1 to 8 parts by weight of water, and 0.5 to 5 or preferably 0.5 to 2 parts by weight of an amide are useful for dyeing paper in the stock and for dyeing paper sheet.
    Type: Grant
    Filed: May 23, 1973
    Date of Patent: May 17, 1977
    Assignee: Sandoz Ltd.
    Inventors: Alfred Frei, Georg Schoefberger, August Schweizer
  • Patent number: 4024262
    Abstract: Substituted hydroxy pyridones, e.g., 3-(1-iminopropyl)-4-hydroxy-6-phenyl-1-methyl-2-(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers, sleep inducers and neuroleptics.
    Type: Grant
    Filed: March 5, 1976
    Date of Patent: May 17, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4024182
    Abstract: Aryl-butadienoic acids, e.g., 4-(p-tetradecyloxyphenyl)-2-methyl-buta-2,3-dienoic acid, are prepared by a process comprising converting an acyl halide of an aryl lower alkanoic acid to its corresponding .beta.,.beta.,.beta.-trichloroethyl ester of the desired aryl-butadienoic acid which is then treated with zinc to obtain the corresponding free arylbutadienoic acid.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: May 17, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4024283
    Abstract: Substituted or unsubstituted thiodimethylene bis(pivalophenone), e.g., 4',4'"-(thiodimethylene) bis(pivalophenone) are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with an alkali metal sulfide and are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: May 17, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4022607
    Abstract: Substituted oxazoles and thiazoles are useful as herbicides.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: May 10, 1977
    Assignee: Sandoz, Inc.
    Inventor: Thomas E. Jackson
  • Patent number: 4020998
    Abstract: The present invention concerns a novel method of winding bobbins having a predetermined radial fluid permeability which comprises winding yarn or fabric on a hollow permeable core, passing a fluid radially through the windings on the core and terminating the winding when a predetermined fluid pressure is attained, and an apparatus therefor.Said method and apparatus enable "bobbins" to be uniformly dyed.
    Type: Grant
    Filed: January 30, 1975
    Date of Patent: May 3, 1977
    Assignee: Sandoz Ltd.
    Inventors: Jose Carbonell, Rolf Hasler, Roland Walliser